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Adipose tissue vascularization

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https://www.readbyqxmd.com/read/28529328/perivascular-adipose-tissue-epiphenomenon-or-local-risk-factor
#1
REVIEW
K Schäfer, I Drosos, S Konstantinides
Obesity is associated with an increased cardiovascular risk, but the mechanisms underlying the link between increased body weight and vascular disease are incompletely understood. Over the past 15 years, perivascular adipose tissue has emerged as active component of the vessel wall involved in vascular homeostasis. However, perivascular adipose tissue can adopt detrimental properties under the influence of obesity and other factors and contribute actively to the pathophysiology of cardiovascular disease. Conversely, changes of the vessel wall may negatively affect perivascular adipose tissue qualities...
May 22, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28521866/neovascular-deterioration-impaired-nadph-oxidase-and-inflammatory-cytokine-expression-in-adipose-derived-multipotent-cells-from-subjects-with-metabolic-syndrome
#2
Wilfredo Oliva-Olivera, Said Lhamyani, Leticia Coín-Aragüez, Daniel Castellano-Castillo, Juan Alcaide-Torres, Elena María Yubero-Serrano, Rajaa El Bekay, Francisco José Tinahones
OBJECTIVE: Expansion of adipose tissue depends on the growth of its vascular network and it has been shown that adipose tissue dysfunction in obese subjects with the metabolic syndrome is associated with decreased angiogenesis. However, some subjects with a high body mass index do not develop metabolic abnormalities associated with obesity. In this study we examined the neovascular properties, expression levels of proteins involved in cellular redox balance and inflammatory cytokines in adipose-derived multipotent mesenchymal cells (ASCs) of subjects with different metabolic profiles...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28521185/association-of-aortic-perivascular-adipose-tissue-density-with-aortic-calcification-in-women-with-systemic-lupus-erythematosus
#3
Kelly J Shields, Samar R El Khoudary, Joseph M Ahearn, Susan Manzi
BACKGROUND AND AIMS: Women with systemic lupus erythematosus (SLE) have an increased risk of cardiovascular disease (CVD). Perivascular adipose tissue (PVAT) surrounds the vascular wall, is associated with CVD risk factors, and may contribute to premature CVD in SLE. We previously found greater volumes of aortic PVAT associated with aortic calcification (AC) in female SLE patients. There is recent evidence that not only volume but adipose density may also be indicative of inflammation...
April 29, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28518106/isolation-of-murine-adipose-tissue-derived-microvascular-fragments-as-vascularization-units-for-tissue-engineering
#4
Florian S Frueh, Thomas Später, Claudia Scheuer, Michael D Menger, Matthias W Laschke
A functional microvascular network is of pivotal importance for the survival and integration of engineered tissue constructs. For this purpose, several angiogenic and prevascularization strategies have been established. However, most cell-based approaches include time-consuming in vitro steps for the formation of a microvascular network. Hence, they are not suitable for intraoperative one-step procedures. Adipose tissue-derived microvascular fragments (ad-MVF) represent promising vascularization units. They can be easily isolated from fat tissue and exhibit a functional microvessel morphology...
April 30, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28503189/eicosapentaenoic-acid-shows-anti-inflammatory-effect-via-gpr120-in-3t3-l1-adipocytes-and-attenuates-adipose-tissue-inflammation-in-diet-induced-obese-mice
#5
Hodaka Yamada, Tomio Umemoto, Masafumi Kakei, Shin-Ichi Momomura, Masanobu Kawakami, San-E Ishikawa, Kazuo Hara
BACKGROUND: Saturated fatty acids have been shown to cause insulin resistance and low-grade chronic inflammation, whereas unsaturated fatty acids suppress inflammation via G-protein coupled receptor 120 (GPR120) in macrophages. However, the anti-inflammatory effects of unsaturated fatty acids in adipocytes have yet to be elucidated. Hence, the aims of the present study were to evaluate the anti-inflammatory effects of eicosapentaenoic acid (EPA) via GPR120 in adipocytes. METHODS: We used 250 μM palmitate as a representative saturated fatty acid...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28499402/erk-signaling-is-required-for-vegf-a-vegfr2-induced-differentiation-of-porcine-adipose-derived-mesenchymal-stem-cells-into-endothelial-cells
#6
Sami G Almalki, Devendra K Agrawal
BACKGROUND: Cell-based therapy that can rejuvenate the endothelium with stimulated adipose-derived mesenchymal stem cells (AMSCs) is a promising therapeutic strategy for the re-endothelialization of denuded arteries at the stenting site. Previously, we have shown that silencing of MMP-2 and MMP-14 inhibits vascular endothelial growth factor receptor type 2 (VEGFR2) cleavage, and induces differentiation of AMSCs toward the endothelial cell (EC) lineage. In this study, we examined the underlying signaling pathways that regulate differentiation of AMSCs to ECs in vitro through VEGFR2...
May 12, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28498891/adipose-tissue-depots-and-inflammation-effects-on-plasticity-and-resident-mesenchymal-stem-cell-function
#7
Lina Badimon, Judit Cubedo
Adipose tissue (AT) is a highly heterogeneous organ. Beside the heterogeneity associated to different tissue types (white, brown and "brite") and its location-related heterogeneity (subcutaneous, visceral, epicardial, and perivascular, etc), AT composition, structure and functionality is highly dependent on individual-associated factors. As such, the pro-inflammatory state associated to the presence of obesity and other cardiovascular risk factors directly affects AT metabolism. Furthermore, the adipose-derived stem cells (ASCs) that reside in the stromal vascular fraction (SVF) of AT, besides being responsible for most of the plasticity attributed to AT, is an additional source of heterogeneity...
May 11, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28490763/methylglyoxal-induced-glycation-changes-adipose-tissue-vascular-architecture-flow-and-expansion-leading-to-insulin-resistance
#8
Tiago Rodrigues, Paulo Matafome, José Sereno, José Almeida, João Castelhano, Luís Gamas, Christian Neves, Sónia Gonçalves, Catarina Carvalho, Amina Arslanagic, Elinor Wilcken, Rita Fonseca, Ilda Simões, Silvia Vilares Conde, Miguel Castelo-Branco, Raquel Seiça
Microvascular dysfunction has been suggested to trigger adipose tissue dysfunction in obesity. This study investigates the hypothesis that glycation impairs microvascular architecture and expandability with an impact on insulin signalling. Animal models supplemented with methylglyoxal (MG), maintained with a high-fat diet (HFD) or both (HFDMG) were studied for periepididymal adipose (pEAT) tissue hypoxia and local and systemic insulin resistance. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was used to quantify blood flow in vivo, showing MG-induced reduction of pEAT blood flow...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28486783/extracorporeal-shock-wave-therapy-in-situ-a-novel-approach-to-obtain-an-activated-fat-graft
#9
E Priglinger, M Sandhofer, A Peterbauer-Scherb, C Wurzer, C Steffenhagen, J Maier, W Holnthoner, S Nürnberger, H Redl, S Wolbank
One of the mainstays of facial rejuvenation strategies is volume restoration which can be achieved by autologous fat grafting. In our novel approach, we treated the adipose tissue harvest site with extracorporeal shock wave therapy (ESWT) in order to improve the quality of the regenerative cells in situ. The latter was demonstrated by characterizing the cells of the stromal vascular fraction (SVF) in the harvested liposuction material regarding cell yield, ATP content, proliferative capacity, surface marker profile, differentiation potential and secretory protein profile...
May 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28486770/melatonin-promotes-survival-of-non-vascularized-fat-grafts-and-enhances-the-viability-and-migration-of-human-adipose-derived-stem-cells-via-down-regulation-of-acute-inflammatory-cytokines
#10
Shaun S Tan, Weiqing Zhan, Christopher J Phoon, Xiaolian Han, Diego Marre, Sholeh Boodhun, Jason A Palmer, Geraldine M Mitchell, Wayne A Morrison
Non-vascularized fat grafting is a valuable technique for soft tissue reconstruction but poor survival of fat in the host environment remains a problem. A process known as cell-assisted transfer is used to enhance fat graft retention by adding stromal vascular fraction, an adipose-derived stem cell (ASC) rich content to lipoaspirate. We have recently shown that the use of melatonin, a ROS scavenger, protects human ASCs from hydrogen peroxide induced oxidative stress and cell death in vitro but its role as a pharmacologic adjunct in clinical fat grafting has not been studied...
May 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28485099/ectopic-bone-formation-by-aggregated-mesenchymal-stem-cells-from-bone-marrow-and-adipose-tissue-a-comparative-study
#11
Eelco M Fennema, Laurent A H Tchang, Huipin Yuan, Clemens A van Blitterswijk, Ivan Martin, Arnaud Scherberich, Jan de Boer
Tissue engineered constructs (TECs) based on spheroids of bone marrow mesenchymal stromal cells (BM-MSCs) combined with calcium phosphate (CaP) micro-particles and enveloped in a platelet-rich-plasma (PRP) hydrogel showed that aggregation of MSCs improves their ectopic bone formation potential. The stromal vascular fraction (SVF) and adipose-derived MSCs (ASCs) have been recognized as interesting MSC source for bone tissue engineering but their ectopic bone formation is limited. We investigated whether aggregation of ASCs could similarly improve ectopic bone formation by ASCs and SVF cells...
May 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28484594/adipose-tissue-lipolysis-and-remodeling-during-the-transition-period-of-dairy-cows
#12
REVIEW
G Andres Contreras, Clarissa Strieder-Barboza, William Raphael
Elevated concentrations of plasma fatty acids in transition dairy cows are significantly associated with increased disease susceptibility and poor lactation performance. The main source of plasma fatty acids throughout the transition period is lipolysis from adipose tissue depots. During this time, plasma fatty acids serve as a source of calories mitigating the negative energy balance prompted by copious milk synthesis and limited dry matter intake. Past research has demonstrated that lipolysis in the adipose organ is a complex process that includes not only the activation of lipolytic pathways in response to neural, hormonal, or paracrine stimuli, but also important changes in the structure and cellular distribution of the tissue in a process known as adipose tissue remodeling...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28482232/control-of-angiogenesis-and-host-response-by-modulating-the-cell-adhesion-properties-of-an-elastin-like-recombinamer-based-hydrogel
#13
Sebastian Manuel Staubli, Giulia Cerino, Israel Gonzalez De Torre, Matilde Alonso, Daniel Oertli, Friedrich Eckstein, Katharina Glatz, José Carlos Rodríguez Cabello, Anna Marsano
The control of the in vivo vascularization of engineered tissue substitutes is essential in order to obtain either a rapid induction or a complete inhibition of the process (e.g. in muscles and hyaline-cartilage, respectively). Among the several polymers available, Elastin-Like Recombinamers (ELR)-based hydrogel stands out as a promising material for tissue engineering thanks to its viscoelastic properties, non-toxicity, and non-immunogenicity. In this study, we hypothesized that varying the cell adhesion properties of ELR-hydrogels could modulate the high angiogenic potential of adipose tissue-derived stromal vascular fraction (SVF) cells, predominantly composed of endothelial/mural and mesenchymal cells...
April 28, 2017: Biomaterials
https://www.readbyqxmd.com/read/28482008/the-microcirculation-a-key-player-in-obesity-associated-cardiovascular-disease
#14
Oana Sorop, T Dylan Olver, Jens van de Wouw, Ilkka Heinonen, Richard W van Duin, Dirk J Duncker, Daphne Merkus
It is increasingly recognized that obesity is a risk factor for microvascular disease, i.e. results in structural and functional changes in the microvasculature. This review aims to describe how obesity impacts the microvasculature of visceral adipose tissue, skeletal muscle, heart, brain, kidneys and lungs. These changes involve endothelial dysfunction, which in turn impacts control of vascular tone, contributes to development of microvascular insulin resistance, alters secretion of paracrine factors like nitric oxide and endothelin, but also influences vascular structure and perivascular inflammation...
May 8, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28481288/an-additive-effect-of-promoting-thermogenic-gene-expression-in-mice-adipose-derived-stromal-vascular-cells-by-combination-of-rosiglitazone-and-cl316-243
#15
You-Lei Li, Xiao Li, Tian-Tuan Jiang, Jia-Min Fan, Xue-Li Zheng, Xin-E Shi, Tai-Yong Yu, Gui-Yan Chu, Gong-She Yang
It is well-documented that CL316,243 (a β3 agonist) or rosiglitazone (a PPARγ agonist) can induce white adipocyte populations to brown-like adipocytes, thus increasing energy consumption and combating obesity. However, whether there is a combined effect remains unknown. In the present study, stromal vascular cells of inguinal white adipose tissue (iWAT-SVCs for short) from mice were cultured and induced into browning by CL316,243, rosiglitazone, or both. Results showed that a combination of CL316,243 and rosiglitazone significantly upregulated the expression of the core thermogenic gene Ucp1 as well as genes related with mitochondrial function (Cidea, Cox5b, Cox7a1, Cox8b, and Cycs), compared with the treatment of CL316,243 or rosiglitazone alone...
May 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28480978/lumbar-multifidus-muscle-degenerates-in-individuals-with-chronic-degenerative-lumbar-spine-pathology
#16
Bahar Shahidi, James C Hubbard, Michael C Gibbons, Severin Ruoss, Vinko Zlomislic, R Todd Allen, Steven R Garfin, Samuel R Ward
Histological and cell-level changes in the lumbar musculature in individuals with chronic lumbar spine degenerative conditions are not well characterized. Although prior literature supports evidence of changes in fiber type and size, little information exists describing the tissue quality and biology of pathological features of muscle in this population. The purpose of this study was to quantify multifidus tissue composition and structure, inflammation, vascularity, and degeneration in individuals with chronic degenerative lumbar spine pathology...
May 8, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28475015/the-cngrcllii-klaklak-2-peptide-shows-cytotoxicity-against-huvecs-by-inducing-apoptosis-an-in-vitro-and-in-vivo-study
#17
Guanying Wang, Na Yuan, Shangke Huang, Lu Feng, Rui Han, Yujiao Zhang, Juan Ren, Min Meng, Xinhan Zhao
Fibrinogen Asn-Gly-Arg motif can specifically recognize and bind to Aminopeptidase N (CD13) on vascular endothelial cells in newly formed tumor vessels. Adipose-derived stem cells can serve as ideal vectors for gene therapy because of their ability of migrating to tumor tissues. First, this study was aimed to design a new peptide (CNGRCLLII(KLAKLAK)2) named CNAK which contains cyclic Asn-Gly-Arg motif and test its biological activity against human umbilical vein endothelial cells. Second, we aimed to construct stably transfected adipose-derived stem cells which express the CNAK peptide and investigate their anti-angiogenic activity in vivo...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28473444/role-of-adipose-tissue-endothelial-adam17-in-age-related-coronary-microvascular-dysfunction
#18
Huijuan Dou, Attila Feher, Alec C Davila, Maritza J Romero, Vijay S Patel, Vinayak M Kamath, Monika Beck Gooz, R Daniel Rudic, Rudolf Lucas, David J Fulton, Neal L Weintraub, Zsolt Bagi
OBJECTIVE: A disintegrin and metalloproteinase ADAM17 (tumor necrosis factor-α [TNF]-converting enzyme) regulates soluble TNF levels. We tested the hypothesis that aging-induced activation in adipose tissue (AT)-expressed ADAM17 contributes to the development of remote coronary microvascular dysfunction in obesity. APPROACH AND RESULTS: Coronary arterioles (CAs, ≈90 µm) from right atrial appendages and mediastinal AT were examined in patients (aged: 69±11 years, BMI: 30...
May 4, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28468789/intracoronary-administration-of-allogeneic-adipose-tissue-derived-mesenchymal-stem-cells-improves-myocardial-perfusion-but-not-left-ventricle-function-in-a-translational-model-of-acute-myocardial-infarction
#19
Joaquim Bobi, Núria Solanes, Rodrigo Fernández-Jiménez, Carlos Galán-Arriola, Ana Paula Dantas, Leticia Fernández-Friera, Carolina Gálvez-Montón, Elisabet Rigol-Monzó, Jaume Agüero, José Ramírez, Mercè Roqué, Antoni Bayés-Genís, Javier Sánchez-González, Ana García-Álvarez, Manel Sabaté, Santiago Roura, Borja Ibáñez, Montserrat Rigol
BACKGROUND: Autologous adipose tissue-derived mesenchymal stem cells (ATMSCs) therapy is a promising strategy to improve post-myocardial infarction outcomes. In a porcine model of acute myocardial infarction, we studied the long-term effects and the mechanisms involved in allogeneic ATMSCs administration on myocardial performance. METHODS AND RESULTS: Thirty-eight pigs underwent 50 minutes of coronary occlusion; the study was completed in 33 pigs. After reperfusion, allogeneic ATMSCs or culture medium (vehicle) were intracoronarily administered...
May 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28468307/markers-of-oxidative-stress-and-antioxidant-defense-in-romanian-patients-with-type-2-diabetes-mellitus-and-obesity
#20
Ariana Picu, Laura Petcu, Simona Ştefan, Manuela Mitu, Daniela Lixandru, Constantin Ionescu-Tîrgovişte, Grațiela Grădișteanu Pîrcălăbioru, Felicia Ciulu-Costinescu, Maria-Viorica Bubulica, Mariana Carmen Chifiriuc
Type 2 diabetes mellitus (T2DM) is strongly associated with obesity. The adipose tissue secretes bioactive adipokines leading to low grade inflammation, amplified by oxidative stress, which promotes the formation of advanced glycation end products and eventually leads to dyslipidemia and vascular complications. The aim of this study was to correlate anthropometric, biochemical and oxidative stress parameters in newly diagnosed (ND) T2DM patients and to investigate the role of oxidative stress in T2DM associated with obesity...
May 1, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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