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https://www.readbyqxmd.com/read/29928584/sampling-pleural-nodules-with-an-ebus-scope-a-novel-application
#1
Michael Kassirer, Jonathan Wiesen, Karine Atlan, Avital Avriel
Convex endobronchial ultrasound transbronchial needle aspiration (C-EBUS-TBNA) has become an essential modality for diagnosis and staging of hilar, mediastinal, and central pulmonary lesions. A Trans-thoracic pleural biopsy is the accepted practice for diagnosing pleural nodules. However, the diagnostic yield of a pleural biopsy is limited and surgical procedures pose a greater risk. We report a unique case of using a C- EBUS scope for the diagnosis of pleural nodules and mediastinal lymph node metastasis in a man with metastatic renal cell carcinoma...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29901594/adult-onset-renal-cell-carcinoma-associated-with-xp11-2-translocation-tfe3-gene-fusion-3-case-reports-and-review-of-literature
#2
Pengfeng Gong, Qianfeng Zhuang, Kun Wang, Renfang Xu, Yiming Chen, Xiaogang Wang, Shuai Yin
RATIONALE: Renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions is a rare subtype of renal cell carcinoma. This predominantly occurs in juveniles, but rarely seen in adults with lymph node or organic metastasis and a worsened prognosis. PATIENTS CONCERNS: Herein, we presented 3 adult cases of Xp11-RCC. Two patients were in early stage and good condition, and the third patient had lymph node metastasis but showed no recurrence after a 3-month follow-up...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29879051/coexistence-of-myasthenia-gravis-and-lambert-eaton-myasthenic-syndrome-in-a-small-cell-lung-cancer-patient-a-case-report
#3
Rui Jia, Jinbo Chen, Ruli Ge, Qi Zheng, Fang Chen, Zhonghua Zhao
RATIONALE: Myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) are both neuromuscular junction diseases, and some controversy exists whether the 2 diseases occur at the same time. PATIENT CONCERNS: We report a case that a patient with presentation of acetylcholine receptor (AChR) antibody positive MG and LEMS associated with small cell lung cancer (SCLC). DIAGNOSES: The patient firstly suffered from fluctuant symptoms, including slurred speech, double eyelid ptosis, and weakness of limbs...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29848810/centrally-located-small-unifocal-hepatocellular-carcinoma-between-minor-conservative-liver-resection-and-major-hepatectomy-case-reports
#4
Emilio De Raffele, Mariateresa Mirarchi, Carmelo Antonio Caserta, Dajana Cuicchi, Gaspare Maria Pendino, Ferdinando Lecce, Stefano Cariani, Bruno Cola
Hepatocellular carcinoma (HCC) is one of the leading cancer in the world, susceptible to potentially curative liver resection (LR) in selected cases. Centrally located HCC (CL-HCC) are sited in central liver segments and may require complex LR because of their relationship to major vascular and biliary structures and deep parenchymal location. Even though extended segment-oriented resections are recommended for oncological reasons, more conservative LR may be indicated in patients with cirrhosis to preserve an adequate function of the future remnant liver (FRL)...
2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29807776/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-the-diagnosis-of-mediastinal-metastases-of-clear-cell-renal-cell-carcinoma
#5
José-Fernando Val-Bernal, María Martino, Félix Romay, Elena Yllera
Evaluation of mediastinal lymphadenopathy in patients with a previous diagnosis of renal cell carcinoma (RCC) is critical for the determination of further treatment. A minimally invasive method of cytology sampling of mediastinal lymph nodes using endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a useful tool in diagnosis. Between January 2010 and April 2018, we performed 1744 EBUS-TBNA studies of mediastinal and hilar lymph nodes for a variety of clinical indications including mediastinal malignancy...
May 22, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29788107/n2-lung-cancer-is-not-all-the-same-an-analysis-of-different-prognostic-groups
#6
Pietro Bertoglio, Sara Ricciardi, Greta Alì, Vittorio Aprile, Stylianos Korasidis, Gerardo Palmiero, Gabriella Fontanini, Alfredo Mussi, Marco Lucchi
OBJECTIVES: The International Association for the Study of Lung Cancer (IASLC) recently proposed a change in the staging system for N2, based on the metastatic station number: N2a1 (a single metastatic station with no hilar involvement), N2a2 (a single metastatic station with hilar involvement) and N2b (multiple metastatic stations). The aim of our study was to validate the IASLC proposal in a cohort of patients with pathological N2 disease. METHODS: All patients with pathological T1-T2 N2 non-small-cell lung cancer who were operated on between 2006 and 2010 in our department were enrolled...
May 19, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29779308/-current-status-of-laparoscopic-techniques-in-the-surgical-treatment-of-biliary-carcinoma
#7
J D Li, Z L Zhao
Biliary carcinoma includes intrahepatic cholangiocarcinoma, hilar cholangiocarcinoma, distal cholangiocarcinoma, and gallbladder cancer. There are few studies about laparoscopic treatment for biliary malignancy due to the complicated dissection of porta hepatic structure, and even reconstruction of biliary tract and(or) vessel under laparoscopy, which increases the difficulty of the laparoscopic radical resection of biliary malignancy. To promote the standardized application and development of laparoscopic techniques in operation of biliary malignancy, the safety and effectiveness of laparoscopic techniques are explained in this paper...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29760926/diffuse-endobronchial-metastasis-from-sigmoid-carcinoma-presenting-as-wheezing-and-respiratory-failure
#8
Nattawat Jantarangsi, Poonchavist Chantranuwatana, Naricha Chirakalwasan
A 66-year-old Thai man with underlying asthma, history of traumatic right haemothorax, and sigmoid carcinoma with bladder invasion developed productive cough, whitish sputum, dyspnoea, and wheezing for 2 months. Physical examination showed generalized expiratory wheezing in both lungs. Computed tomography scan of the chest revealed diffuse thickening of bronchial wall, predominantly at lower lobes; several various sizes of pulmonary nodules; diffuse interlobular septal thickening; multiple enlarged mediastinal lymph nodes and hilar lymph nodes; and right pleural effusion...
July 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29755067/-prognostic-significance-of-mode-of-nodal-involvement-in-pulmonary-pn1-squamous-cell-carcinoma
#9
Motoaki Yasukawa, Takeshi Kawaguchi, Norikazu Kawai, Takashi Tojo, Shigeki Taniguchi
According to the tumor, node, metastasis (TNM) classification of the Union for International Cancer Control (UICC) and the International Association for the Study of Lung Cancer (IASLC), N factor is defined by the anatomic extent of the metastatic lymph nodes, but is not related to the metastatic pattern. N1 is defined as "metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary nodes, including involvement by direct extension". Lymph node involvement is one of the most important prognosistic factors in non-small cell lung cancer patients...
March 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29740587/the-effect-of-anatomical-location-of-lymph-node-metastases-on-cancer-specific-survival-in-patients-with-clear-cell-renal-cell-carcinoma
#10
Alessandro Nini, Alessandro Larcher, Francesco Cianflone, Francesco Trevisani, Carlo Terrone, Alessandro Volpe, Federica Regis, Alberto Briganti, Andrea Salonia, Francesco Montorsi, Roberto Bertini, Umberto Capitanio
Background: Positive nodal status (pN1) is an independent predictor of survival in renal cell carcinoma (RCC) patients. However, no study to date has tested whether the location of lymph node (LN) metastases does affect oncologic outcomes in a population submitted to radical nephrectomy (RN) and extended lymph node dissection (eLND). Objective: To describe nodal disease dissemination in clear cell RCC (ccRCC) patients and to assess the effect of the anatomical sites and the number of nodal areas affected on cancer specific mortality (CSM)...
2018: Frontiers in Surgery
https://www.readbyqxmd.com/read/29707321/clinical-significance-of-skipping-mediastinal-lymph-node-metastasis-in-n2-non-small-cell-lung-cancer
#11
Jun Zhao, Jiagen Li, Ning Li, Shugeng Gao
Background: Lymph node metastasis is critical for the prognosis of non-small cell lung cancer (NSCLC) patients, and understanding of the pattern of lymph node metastasis is key to the treatment. We aim to investigate the N2 NSCLC patients without N1 lymph node involvement. Methods: From 1999 to 2005, a total of 803 patients with pN2 NSCLC were enrolled in this study. Among them, 137 pN2 patients with no metastasis at the hilar (N1) lymph nodes [skip (+) group] were compared with the other 666 patients [skip (-) group]...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29661179/outcomes-of-pathologic-stage-t3a-renal-cell-carcinoma-up-staged-from-small-renal-tumor-emphasis-on-partial-nephrectomy
#12
Hakmin Lee, Minseung Lee, Sang Eun Lee, Seok-Soo Byun, Hyeon Hoe Kim, Cheol Kwak, Sung Kyu Hong
BACKGROUND: The prognosis of patients with pathologic stage T3a renal cell carcinoma (RCC) that is up-staged from a small renal tumor remains controversial. We evaluated the prognosis of patients with RCC who were up-staged from clinical stage T1 to pathologic stage T3a. METHODS: We retrospectively reviewed the data of 3431 patients who were surgically treated for clinical stage T1 RCC. The survival outcomes were compared using Kaplan-Meier and Cox proportional analyses...
April 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29607193/two-cases-of-combined-thoracoscopy-and-open-chest-surgery-for-locally-advanced-lung-carcinoma
#13
Hitoshi Dejima, Hiroaki Kuroda, Katsutoshi Seto, Shozo Sakata, Takaaki Arimura, Tetsuya Mizuno, Noriaki Sakakura, Yukinori Sakao
Thoracoscopic surgery is becoming more widely used in thoracic surgery and has an increasingly important role to play. However, its use for locally advanced carcinoma (clinical stage T3-4) remains controversial. We adapted our procedure by combining thoracoscopy and open chest surgery (combination surgery) with the aim of reducing invasiveness while ensuring that the operation is safe and curative. Here we describe our experience. Case 1 was a man in his 60s who underwent induction chemoradiotherapy (cisplatin plus vinorelbine plus 40 Gy radiotherapy) followed by radical surgery for a left apical lung carcinoma with chest wall invasion...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29593929/colorectal-cancer-presenting-as-single-pulmonary-hilar-lymph-node-metastasis
#14
Ahmed M Habib, Xenophon Kassianides, Samuel Chan, Mahmoud Loubani, Syed Qadri
Colorectal carcinoma is the second biggest cancer responsible for mortality. Lung metastasis is the commonest, following the liver. It is not uncommon to perform pulmonary metastasectomy and identify mediastinal metastasis. Previous studies have identified incidental lymph node involvement following routine mediastinal lymph node clearance in 20-50% of cases. However, solitary intrathoracic lymph node metastasis is exceedingly rare. Even when present, it is usually metachronous. In our case, we present an exceedingly rare case whereby the intrathoracic lymph node metastasis is solitary, not accompanying pulmonary disease and with no liver metastasis...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29578041/intraoperative-conversion-from-partial-to-radical-nephrectomy-incidence-predictive-factors-and-outcomes
#15
Firas G Petros, Sarp K Keskin, Kai-Jie Yu, Roger Li, Michael J Metcalfe, Bryan M Fellman, Courtney M Chang, Cindy Gu, Pheroze Tamboli, Surena F Matin, Jose A Karam, Christopher G Wood
OBJECTIVE: To evaluate preoperative and intraoperative predictors of conversion to radical nephrectomy (RN) in a cohort of patients undergoing a planned partial nephrectomy (PN) for renal cell carcinoma (RCC). METHODS: A single-center, retrospective review was conducted using our PN database that includes patients who were scheduled to undergo PN (regardless of the approach) but were converted to RN between August 1990 and December 2016. Reasons for conversion were collected from the operative report...
March 22, 2018: Urology
https://www.readbyqxmd.com/read/29561464/castleman-disease-in-the-hilum-liver-mimicking-the-lymph-node-metastasis-of-hepatocellular-carcinoma-on-18f-fdg-pet-ct-a-case-report
#16
Yan Hu, Yalan Liu, Hongcheng Shi
RATIONALE: Castleman disease is a rare lymphoproliferative disorder which etiology is unknown. It is divided into 2 subtypes: the plasma cell variant and the hyaline vascular variant. The most common site is the hilum of the lungs and mediastinum. Castleman disease is often ignored by clinicians because of not frequently encountering in clinical and the lower uptake of F-FDG. Here, we report a case of hepatocellular carcinoma accompanied by Castleman disease in the hilum of the liver, which was misdiagnosed as the lymph node metastasis in F-FDG PET/CT imaging...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29560759/chromophobe-renal-cell-carcinoma-with-retrograde-venous-invasion-and-gain-of-chromosome-21-potential-harbingers-of-aggressive-clinical-behavior
#17
Mohsin Jamal, Kanika Taneja, Sohrab Arora, Ravi Barod, Craig G Rogers, Jessica Sanchez, Nilesh S Gupta, Sean R Williamson
Occasionally, renal cell carcinoma (RCC) with renal vein extension spreads against the flow of blood within vein branches into the kidney, forming multifocal nodules throughout the renal parenchyma. These foci are not regarded as multiple tumors but rather reverse spread of tumor along the venous system. This intravascular spread has previously been reported in clear cell RCC and RCC unclassified. However, to our knowledge, this has never been reported in chromophobe RCC. Chromophobe RCC is a unique histologic subtype of renal cancer, generally thought to have less aggressive behavior...
March 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29560675/jaundice-in-a-pregnant-woman
#18
Sophiane Ibrahimi, Abbas Ali Mroué, Erik Francois, Robert Jagodzinski
A 34-year-old woman in the 22nd week of gestation presented with generalized pruritis and weight loss since the first trimester of pregnancy. Physical examination revealed cutaneous scratch lesions, jaundice, and hepatomegaly. Blood tests revealed cholestasis with elevated direct bilirubinemia. Auto-antibody and viral hepatitis tests were negative. Liver ultrasound was normal. The initial diagnosis was cholestasis of pregnancy. However despite treatment with ursodeoxycholic acid, the patient did not improve...
July 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29548309/acantholytic-squamous-cell-carcinoma-of-the-lung-with-marked-lymphogenous-metastases-and-high-titers-of-myeloperoxidase-antineutrophil-cytoplasmic-antibodies-a-case-report
#19
Kenji Yorita, Kazuya Tsuji, Yoko Takano, Naoto Kuroda, Kei Sakamoto, Kaoru Arii, Yukio Yoshimoto, Kimiko Nakatani, Satoshi Ito
BACKGROUND: Acantholytic squamous cell carcinoma (ASQCC), histologically characterized by intercellular bridge loosening, is recognized as a rare variant of squamous cell carcinoma (SQCC). ASQCC may demonstrate a worse prognosis than conventional SQCC. Pulmonary ASQCC is particularly rare; its biological behavior and prognostic data have not been reported. CASE PRESENTATION: We report the clinical and autopsy findings of a 71-year-old Japanese man with pulmonary ASQCC...
March 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29526176/-the-initial-experience-of-video-assisted-thoracic-surgery-segmentectomy-for-early-stage-lung-cancer
#20
Shaohua Ma, Tiansheng Yan, Keyi Wang, Jingdi Wang, Jintao Song, Tong Wang, Wei He, Jie Bai, Liang Jin, Hailong Liang
BACKGROUND: Segmentectomy can retains more healthy lung tissue than lobectomy, but it remains controversial in oncology for early stage lung cancer. The aim of this study is to discuss the problems of video-assisted thoracic surgery (VATS) segmentectomy in early stage lung cancer, by analyzing the clinical and pathological data of 35 cases and reviewing the literature. METHODS: There were 35 patients who received segmentectomy by complete video-assisted thoracic surgery, from May 2013 to July 2017, in single operation group in the Third Hospital of Peking University...
February 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
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