keyword
https://read.qxmd.com/read/38537161/serum-hsp70-and-vegf-levels-are-effective-predictive-factors-of-chemoradiosensitivity-and-prognosis-of-pancreatic-cancer-patients
#1
JOURNAL ARTICLE
Liumei Xiong, Danming Li, Gui Xiao, Sipin Tan, Jianbo Wen, Guiliang Wang
AIM: To evaluate the value of serum HSP70 and VEGF levels for predicting the chemoradiosensitivity of the pancreatic cancer patients. METHODS: A total of 255 patients with pancreatic cancer and 60 healthy subjects were enrolled in this study. Serum levels of HSP70 and VEGF were measured using enzyme-linked immunosorbent assay (ELISA) for the pre-treatment, during-treatment and post- chemoradiotherapy time-points. The results were analyzed to evaluate the potential of serum HSP70 and VEGF levels for predicting the chemoradiosensitivity of pancreatic cancer patients...
March 27, 2024: Pancreas
https://read.qxmd.com/read/38534131/effect-of-an-arsenic-mitigation-program-on-arsenic-exposure-in-american-indian-communities-a-cluster-randomized-controlled-trial-of-the-community-led-strong-heart-water-study-program
#2
JOURNAL ARTICLE
Christine Marie George, Tracy Zacher, Kelly Endres, Francine Richards, Lisa Bear Robe, David Harvey, Lyle G Best, Reno Red Cloud, Annabelle Black Bear, Leslie Skinner, Christa Cuny, Ana Rule, Kellogg J Schwab, Joel Gittelsohn, Ronald Alexander Glabonjat, Kathrin Schilling, Marcia O'Leary, Elizabeth D Thomas, Jason Umans, Jianhui Zhu, Lawrence H Moulton, Ana Navas-Acien
BACKGROUND: Chronic arsenic exposure has been associated with an increased risk of cardiovascular disease; diabetes; cancers of the lung, pancreas and prostate; and all-cause mortality in American Indian communities in the Strong Heart Study. OBJECTIVE: The Strong Heart Water Study (SHWS) designed and evaluated a multilevel, community-led arsenic mitigation program to reduce arsenic exposure among private well users in partnership with Northern Great Plains American Indian Nations...
March 2024: Environmental Health Perspectives
https://read.qxmd.com/read/38533139/unraveling-proto-oncogene-erbb2-expression-in-patients-with-carcinoma-head-of-pancreas-and-chronic-pancreatitis-patients-a-case-control-study
#3
JOURNAL ARTICLE
Abhina Mohanan, Pottakkat Biju, Balasubramaniyan V, Gladwin V
Background The pre-malignant tendency of the normal, non-affected portion of the pancreas is not as well explored as the multicentricity documented in pancreatic cancer cases. In order to ascertain the expression of inflammatory markers and Erythroblastic Oncogene B ( ErbB2 ) in the non-affected pancreas in patients with pancreatic cancer, a case-control study was carried out. Materials and methods In patients who underwent pancreatoduodenectomy for pancreatic cancer (PC), pro-inflammatory genes and a tumor marker, erythroblastic oncogene 2 ( ErbB2 ) in the epidermal growth factor receptor family were analyzed in the pancreatic tissue at the cut surface of the normal pancreas using qRT-PCR...
February 2024: Curēus
https://read.qxmd.com/read/38530967/poly-adp-ribose-polymerase-1-parp-1-is-a-good-prognostic-marker-for-pancreatic-periampullary-cancers
#4
JOURNAL ARTICLE
Kwangil Yim, Kyung Jin Seo, Jamshid Abdul-Ghafar, Mohammad Rizwan Alam, Kwang Yeol Paik, Yosep Chong, Ok Ran Shin
BACKGROUND: Periampullary cancer (PAC) is highly aggressive with no effective adjuvant therapy or prognostic markers. Recently, poly (ADP-ribose) polymerases-1 (PARP-1) have emerged as a target in solid cancers, and its relationship with epithelial-mesenchymal transition (EMT) has been observed. However, the relationship between PARP-1 and EMT in PAC has not explored well. METHODS: We assessed the prognostic significance of PARP1 in 190 PACs patients and correlated it with EMT markers, including FGF8, FGFR4, MMP2, MMP3, Snail, and ZEB1...
March 27, 2024: Pancreas
https://read.qxmd.com/read/38530957/morphology-of-the-dorsal-pancreatic-artery-and-its-oncological-significance-in-pancreatic-cancer
#5
JOURNAL ARTICLE
Takahiro Kyuno, Isamu Makino, Hirohisa Kitagawa, Hirofumi Terakawa, Ryosuke Gabata, Tomokazu Tokoro, Satoshi Takada, Mitsuyoshi Okazaki, Shinichi Nakanuma, Tetsuo Ohta, Shintaro Yagi
OBJECTIVES: Although the dorsal pancreatic artery (DPA) is an important artery that supplies the pancreas, its morphology has not been sufficiently studied. We investigated the morphology of the DPA and the progression of pancreatic cancer along this vessel. MATERIALS AND METHODS: Overall, 142 patients with pancreatic cancer who underwent surgical resection at Kanazawa University Hospital between 2004 and 2015 were enrolled. We examined the morphology of the DPA using preoperative computed tomography and cancer progression along the DPA using resected specimens...
March 13, 2024: Pancreas
https://read.qxmd.com/read/38530956/multicenter-prospective-cohort-study-of-neoadjuvant-chemotherapy-for-borderline-resectable-pancreatic-cancer-ypb-001
#6
JOURNAL ARTICLE
Hiroto Matsui, Tatsuya Ioka, Tsuyoshi Takahashi, Toru Kawaoka, Yoshinari Maeda, Noboru Yahara, Hidefumi Kubo, Taku Nishimura, Toshihiro Inokuchi, Eijiro Harada, Yoshitaro Shindo, Yukio Tokumitsu, Masao Nakajima, Taro Takami, Katsuyoshi Ito, Hidekazu Tanaka, Kimikazu Hamano, Hiroaki Nagano
OBJECTIVES: The present multicenter prospective observational study investigated the effectiveness and safety of neoadjuvant chemotherapy (NAC) for patients with borderline resectable pancreatic cancer (BRPC) and those with RPC contacting major vessels, with respect to a historical control of upfront surgery. MATERIALS AND METHODS: Patients with BRPC and RPC contacting major vessels were prospectively registered and administered NAC with durations and regimens determined by the corresponding treating physician...
March 4, 2024: Pancreas
https://read.qxmd.com/read/38530952/a-case-series-of-choroidal-and-orbital-neuroendocrine-tumors-metastasis-2-patients-treated-with-prrt
#7
JOURNAL ARTICLE
Tony Zibo Zhuang, Chris Bergstrom, Bassel F El-Rayes, Walid L Shaib
Neuroendocrine tumors are rare cancers with heterogenous histologies, response to treatments and prognoses. Majority of these cancers originate in the gastrointestinal tract and metastasize to the liver. We are reporting 5 patients with low-grade neuroendocrine tumor disease with rare metastases to the choroids. Two of the patients were treated with peptide receptor radionuclide therapy (Lutitium-177). This is the first report confirming PRRT safety in patients with low grade NET with ocular metastases.
March 14, 2024: Pancreas
https://read.qxmd.com/read/38530945/the-global-burden-of-early-onset-pancreatic-cancer-and-its-risk-factors-a-perspective-from-global-burden-of-disease-study-2019
#8
JOURNAL ARTICLE
Pojsakorn Danpanichkul, Kanokphong Suparan, Aunchalee Jaroenlapnopparat, Natchaya Polpichai, Panisara Fangsaard, Areeya Detboon, Pinyada Moolkaew, Adivitch Sripusanapan, Karan Srisurapanont, Yatawee Kanjanakot, Kwanjit Duangsonk, Michael B Wallace, Karn Wijarnpreecha
OBJECTIVES: Despite evidence of increased incidence of early-onset pancreatic cancer (EOPC), defined as pancreatic cancer diagnosed in patients below 50 years old, and its risk factors in the Western region, global epidemiological data addressing this issue is still lacking. MATERIALS AND METHODS: Utilizing data from the Global Burden of Disease Study 2019, we aimed to conduct a comprehensive analysis of the incidence, deaths, and disability-adjusted life years (DALYs) associated with EOPC and its risk factors, including smoking, obesity, and diabetes...
March 13, 2024: Pancreas
https://read.qxmd.com/read/38530942/important-radiologic-and-clinical-factors-for-predicting-overall-survival-in-pancreatic-adenocarcinoma-patients-who-underwent-folfirinox
#9
JOURNAL ARTICLE
Sae-Jin Park, Jung Hoon Kim, Seo-Youn Choi, Ijin Joo
BACKGROUND: To predict poor overall survival (OS) in pancreatic adenocarcinoma (PAC) who underwent FOLFIRINOX (5-fluorouracil/leucovorin/irinotecan/oxaliplatin) using clinical and computed tomography (CT) findings. METHODS: A total of 189 patients with PAC who received FOLFIRINOX were retrospectively included. Two reviewers assessed CT findings and resectability based on National Comprehensive Cancer Network guidelines. They determined tumor size changes according to Response Evaluation Criteria in Solid Tumors (RECIST 1...
March 13, 2024: Pancreas
https://read.qxmd.com/read/38529489/ehmt2-inactivation-in-pancreatic-epithelial-cells-shapes-the-transcriptional-landscape-and-inflammation-response-of-the-whole-pancreas
#10
Gareth Pollin, Angela J Mathison, Thiago M de Assuncao, Anju Thomas, Lida Zeighami, Ann Salmonson, Hongfei Liu, Guillermo Urrutia, Pallavi Vankayala, Stephen J Pandol, Michael T Zimmermann, Juan Iovanna, Victor X Jin, Raul Urrutia, Gwen Lomberk
The Euchromatic Histone Methyl Transferase Protein 2 (EHMT2), also known as G9a, deposits transcriptionally repressive chromatin marks that play pivotal roles in the maturation and homeostasis of multiple organs. Recently, we have shown that EHMT2 inactivation alters growth and immune gene expression networks, antagonizing KRAS-mediated pancreatic cancer initiation and promotion. Here, we elucidate the essential role of EHMT2 in maintaining a transcriptional landscape that protects organs from inflammation...
March 16, 2024: bioRxiv
https://read.qxmd.com/read/38528516/peli1-key-players-in-the-oncogenic-characteristics-of-pancreatic-cancer
#11
JOURNAL ARTICLE
Xiaobin Fei, Changhao Zhu, Peng Liu, Songbai Liu, Likun Ren, Rishang Lu, Junyi Hou, Yongjia Gao, Xing Wang, Yaozhen Pan
BACKGROUND: Pancreatic cancer (PC) is a highly malignant gastrointestinal tumor, which is characterized by difficulties in early diagnosis, early metastasis, limited therapeutic response and a grim prognosis. Therefore, it is imperative to explore potential therapeutic targets for PC. Currently, although the involvement of the Pellino E3 Ubiquitin Protein Ligase 1 (PELI1) in the human growth of some malignant tumors has been demonstrated, its association with PC remains uncertain. METHODS: Bioinformatics, qRT-PCR, Western blot and IHC were used to detect the expression of PELI1 in pancreas or PC tissues and cells at mRNA and protein levels...
March 25, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38524385/pancreatic-adenocarcinoma-of-the-tail-unveiling-a-rare-presentation-with-venous-thrombosis-a-case-report-and-literature-review
#12
Syeda Abiha Rabab, Syeda Mahrukh Fatima Zaidi, Ayesha Amjad, Paras, Maryam Sattar
Pancreatic cancer is a silent and lethal adversary that often conceals its presence until advanced stages. This report elucidates a distinctive case of a 46-year-old patient with pancreatic tail adenocarcinoma presenting with venous thrombosis, a rare manifestation. The patient's symptoms included severe left leg pain, swelling, and redness, accompanied by weight loss and decreased appetite. Laboratory findings indicated a prothrombotic state, whereas imaging revealed a substantial mass on the tail of the pancreas with hepatic metastasis...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38523536/the-relationship-between-statin-intake-and-risk-of-pancreatic-cancer-a-systematic-review-and-meta-analysis
#13
Hesamaldin Bagheri, Omid-Ali Adeli, Saeid Heidari-Soureshjani, Zahra Azadegan-Dehkordi, Catherine Mt Sherwin
BACKGROUND: Pancreatic neoplasm is one of the types of cancer with a high incidence and case-fatality rate. OBJECTIVES: This study was designed to investigate the relationship between statin intake and the risk of pancreatic cancer with a systematic review and meta-analysis approach. METHODS: This study was a systematic review and meta-analysis of studies published before 2023 in Cochrane Library, Web of Science (WOS), PubMed, Google Scholar, ScienceDirect, Scopus, and Embase databases...
March 20, 2024: Current Drug Research Reviews
https://read.qxmd.com/read/38521069/nanodrug-bacteria-conjugates-mediated-oncogenic-collagen-depletion-enhances-immune-checkpoint-blockade-therapy-against-pancreatic-cancer
#14
JOURNAL ARTICLE
Zhaoting Li, Fanyi Mo, Kai Guo, Shuai Ren, Yixin Wang, Yu Chen, Patrick B Schwartz, Nathaniel Richmond, Fengyuan Liu, Sean M Ronnekleiv-Kelly, Quanyin Hu
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) cancer cells specifically produce abnormal oncogenic collagen to bind with integrin α3β1 receptor and activate the downstream focal adhesion kinase (FAK), protein kinase B (AKT), and mitogen-activated protein kinase (MAPK) signaling pathway. Collectively, this promotes immunosuppression and tumor proliferation and restricts the response rate of clinical cancer immunotherapies. METHODS: Here, by leveraging the hypoxia tropism and excellent motility of the probiotic Escherichia coli strain Nissle 1917 (ECN), we developed nanodrug-bacteria conjugates to penetrate the extracellular matrix (ECM) and shuttle the surface-conjugated protein cages composed of collagenases and anti-programmed death-ligand 1 (PD-L1) antibodies to PDAC tumor parenchyma...
March 21, 2024: Med
https://read.qxmd.com/read/38519394/integrin-%C3%AE-v%C3%AE-6-targeted-peptide-toxin-therapy-in-a-novel-%C3%AE-v%C3%AE-6-expressing-immunocompetent-model-of-pancreatic-cancer
#15
JOURNAL ARTICLE
Nicholas F Brown, Elizabeth R Murray, Lauren C Cutmore, Philip Howard, Luke Masterson, Francesca Zammarchi, John A Hartley, Patrick H van Berkel, John F Marshall
Previously we reported that a novel αvβ6-specific peptide-drug conjugate (SG3299) could eliminate established human pancreatic ductal adenocarcinoma (PDAC) xenografts. However the development of effective therapies for PDAC, which is an essential need, must show efficacy in relevant immunocompetent animals. Previously we reported that the KPC mouse transgenic PDAC model that closely recapitulates most stages of development of human PDAC, unlike in humans, failed to express αvβ6 on their tumours or metastases...
February 24, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38518378/convolutional-lstm-model-for-cine-image-prediction-of-abdominal-motion
#16
JOURNAL ARTICLE
Jingxi Weng, Sri Hrushikesh Varma Bhupathiraju, Thomas Samant, Alex Dresner, Jian Wu, Sanjiv S Samant
Objective

In this study, we tackle the challenge of latency in Magnetic Resonance Linear Accelerator (MR-Linac) systems, which compromises target coverage accuracy in gated real-time radiotherapy. Our focus is on enhancing motion prediction precision in abdominal organs to address this issue. We developed a convolutional Long Short-Term Memory (convLSTM) model, utilizing 2D cine magnetic resonance (cine-MR) imaging for this purpose.

Approach

Our model, featuring a sequence-to-one architecture with six input frames and one output frame, employs Structural Similarity Index Measure (SSIM) as loss function...
March 22, 2024: Physics in Medicine and Biology
https://read.qxmd.com/read/38518061/pancreatic-cysts-greater-than-1-cm-are-associated-with-an-increased-risk-for-developing-pancreatic-cancer-in-individuals-from-pancreatic-cancer-prone-kindreds-undergoing-surveillance
#17
JOURNAL ARTICLE
Muaz Aijazi, Kenneth E Fasanella, Kevin McGrath, Lynette M Smith, Aatur D Singhi, Randall E Brand
BACKGROUND: The International Cancer of the Pancreas Screening Consortium recommended annual imaging for individuals at increased risk for developing a pancreatic ductal adenocarcinoma (PDAC) who did not have concerning pancreatic findings or a cyst <3 cm without worrisome features. We aimed to determine if 3-cm cyst size accurately predicted advanced precursor lesions in high-risk individuals undergoing surveillance. METHODS: Imaging for high-risk individuals (HRIs) undergoing PDAC surveillance from 2007 to 2021 was reviewed and pancreatic abnormalities were recorded including dominant cyst size and number of cysts...
April 1, 2024: Pancreas
https://read.qxmd.com/read/38517481/handgrip-strength-predicts-survival-in-patients-with-pancreatic-cancer
#18
JOURNAL ARTICLE
Julia Freckelton, Ashray Rajagopalan, Gregory T Moore, Daniel Croagh
OBJECTIVES: Pancreatic ductal adenocarcinoma (PDAC) is a common cancer with a poor prognosis and is associated with a high prevalence of cachexia, a metabolic syndrome of muscle wasting due to complex mechanisms. In addition to loss of muscle mass, cancer patients also experience functional deterioration. The aim of this study is to determine whether there is an association between muscle mass and function and clinical outcomes, particularly survival. METHODS: We performed a prospective cohort study including all patients with PDAC at Monash Health from March 2016 to December 2017...
March 21, 2024: Pancreas
https://read.qxmd.com/read/38517462/cancer-screening-with-multicancer-detection-tests-a-translational-science-review
#19
REVIEW
Wendy S Rubinstein, Christos Patriotis, Anthony Dickherber, Paul K J Han, Hormuzd A Katki, Elyse LeeVan, Paul F Pinsky, Philip C Prorok, Amanda L Skarlupka, Sarah M Temkin, Philip E Castle, Lori M Minasian
Multicancer detection (MCD) tests use a single, easily obtainable biospecimen, such as blood, to screen for more than one cancer concurrently. MCD tests can potentially be used to improve early cancer detection, including cancers that currently lack effective screening methods. However, these tests have unknown and unquantified benefits and harms. MCD tests differ from conventional cancer screening tests in that the organ responsible for a positive test is unknown, and a broad diagnostic workup may be necessary to confirm the location and type of underlying cancer...
March 22, 2024: CA: a Cancer Journal for Clinicians
https://read.qxmd.com/read/38516904/liquid-biopsy-of-wash-samples-obtained-via-endoscopic-ultrasound-guided-fine-needle-biopsy-comparison-with-liquid-biopsy-of-plasma-in-pancreatic-cancer
#20
JOURNAL ARTICLE
Hiroshi Ohyama, Yosuke Hirotsu, Kenji Amemiya, Hiroyuki Amano, Sumio Hirose, Toshio Oyama, Yuji Iimuro, Yuichiro Kojima, Rintaro Mikata, Hitoshi Mochizuki, Naoya Kato, Masao Omata
OBJECTIVES: Pancreatic cancer (PC) has a poor prognosis and limited treatment options. Liquid biopsy, which analyzes circulating tumor DNA (ctDNA) in blood, holds promise for precision medicine; however, low ctDNA detection rates pose challenges. This study aimed to investigate the utility of wash samples obtained via endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) as a liquid biopsy for PC. METHODS: A total of 166 samples (42 formalin-fixed paraffin-embedded [FFPE] tissues, 80 wash samples, and 44 plasma samples) were collected from 48 patients with PC for genomic analysis...
March 22, 2024: Diagnostic Cytopathology
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