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https://www.readbyqxmd.com/read/29332278/exposure-to-nanoscale-and-microscale-particulate-air-pollution-prior-to-mining-development-near-a-northern-indigenous-community-in-qu%C3%A3-bec-canada
#1
Avik J Ghoshdastidar, Zhenzhong Hu, Yevgen Nazarenko, Parisa A Ariya
This study serves as a baseline characterization of indoor and outdoor air quality in a remote northern indigenous community prior to the start of a major nearby mining operation, including measurements of nanoparticles, which has never been performed in this context before. We performed aerosol sample collection and real-time aerosol measurements at six different locations at the Cree First Nation of Waswanipi and the Montviel campsite, located 45 km west of the Cree First Nation of Waswanipi, in the south of the Nord-du-Québec region...
January 14, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29332007/impacts-of-canada-s-minimum-age-for-tobacco-sales-mats-laws-on-youth-smoking-behaviour-2000-2014
#2
Russell Clarence Callaghan, Marcos Sanches, Jodi Gatley, James K Cunningham, Michael Oliver Chaiton, Robert Schwartz, Susan Bondy, Claire Benny
BACKGROUND: Recently, the US Institute of Medicine has proposed that raising the minimum age for tobacco purchasing/sales to 21 years would likely lead to reductions in smoking behavior among young people. Surprisingly few studies, however, have assessed the potential impacts of minimum-age tobacco restrictions on youth smoking. OBJECTIVE: To estimate the impacts of Canadian minimum age for tobacco sales (MATS) laws on youth smoking behaviour. DESIGN: A regression-discontinuity design, using seven merged cycles of the Canadian Community Health Survey, 2000-2014...
January 13, 2018: Tobacco Control
https://www.readbyqxmd.com/read/29329508/hospital-readmissions-and-the-day-of-the-week
#3
Aman Verma, Christian Rochefort, Guido Powell, David Buckeridge
Objectives Patients discharged from hospitals on a Friday (Friday discharges) are readmitted sooner (a shorter time-to-emergency-readmission) than those discharged on any other day of the week. To evaluate the cost-effectiveness of increasing weekend capacity, the effect estimate of Friday discharge on time-to-emergency-readmission needs to be precise. However, precise effect estimation is complicated by the confounding effect of differing healthcare-seeking behaviour and admission practices, and therefore different admission probability, by day of the week...
January 2018: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29327608/pregnancy-outcomes-of-women-with-spina-bifida
#4
Nathalie Auger, Laura Arbour, Mireille E Schnitzer, Jessica Healy-Profitós, Geneviève Nadeau, William D Fraser
PURPOSE: To assess the pregnancy outcomes of women with spina bifida. MATERIALS AND METHODS: We analyzed a population-based cohort of 397 pregnant women with spina bifida and 1,083,211 without spina bifida who delivered infants in hospitals in Quebec, Canada, 1989-2013. Outcomes included maternal and infant morbidity and mortality at delivery. We used log-binomial regression models to estimate prevalence ratios (PR) and 95% confidence intervals (CI) for the association of maternal spina bifida with pregnancy outcomes, accounting for maternal characteristics...
January 12, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29327149/gestational-diabetes-and-risk-of-cardiovascular-disease-up-to-25%C3%A2-years-after-pregnancy-a-retrospective-cohort-study
#5
Safyer McKenzie-Sampson, Gilles Paradis, Jessica Healy-Profitós, Frédérique St-Pierre, Nathalie Auger
AIMS: The risk of cardiovascular disease in women with gestational diabetes is poorly understood. We sought to determine whether gestational diabetes increases the risk of cardiovascular disease more than two decades after pregnancy. METHODS: We carried out a retrospective cohort study of 1,070,667 women who delivered infants in hospitals within Quebec, Canada, between 1989 and 2013. We followed 67,356 women with gestational diabetes and 1,003,311 without gestational diabetes for a maximum of 25...
January 11, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29326876/mildly-elevated-succinylacetone-and-normal-liver-function-in-compound-heterozygotes-with-pathogenic-and-pseudodeficient-fah-alleles
#6
Hao Yang, Francis Rossignol, Denis Cyr, Rachel Laframboise, Shu Pei Wang, Jean-François Soucy, Marie-Thérèse Berthier, Yves Giguère, Paula J Waters, Grant A Mitchell
Background: A high level of succinylacetone (SA) in blood is a sensitive, specific marker for the screening and diagnosis of hepatorenal tyrosinemia (HT1, MIM 276700). HT1 is caused by mutations in the FAH gene, resulting in deficiency of fumarylacetoacetate hydrolase. HT1 newborns are usually clinically asymptomatic, but have coagulation abnormalities revealing liver dysfunction. Treatment with nitisinone (NTBC) plus dietary restriction of tyrosine and phenylalanine prevents the complications of HT1...
March 2018: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/29322311/minimally-invasive-transforaminal-lumbar-interbody-fusion-with-unilateral-pedicle-screw-fixation-unilif-morbidity-clinical-and-radiological-2-year-outcomes-of-a-66-patient-prospective-series
#7
H Giorgi, R Prebet, R Andriantsimiavona, P Tropiano, B Blondel, H F Parent
PURPOSE: To assess clinical and radiological outcomes at 2-year follow-up of one-level minimally invasive transforaminal interbody fusion with unilateral pedicle screw fixation (UNILIF) in the treatment of stable lumbar degenerative diseases. METHODS: From January 1, 2012 to January 31, 2013, we prospectively collected clinical and radiological data on patients with stable degenerative lumbar disease managed by UNILIF in a single institution. Preoperatively and at 2 years, we recorded ODI, SF-12, Quebec and VAS...
January 10, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29321047/effects-of-concentrated-long-chain-omega-3-polyunsaturated-fatty-acid-supplementation-before-radical-prostatectomy-on-prostate-cancer-proliferation-inflammation-and-quality-of-life-study-protocol-for-a-phase-iib-randomized-double-blind-placebo-controlled-trial
#8
Marie-Hélène Guertin, Karine Robitaille, Jean-François Pelletier, Thierry Duchesne, Pierre Julien, Josée Savard, Isabelle Bairati, Vincent Fradet
BACKGROUND: Prostate cancer is the most commonly diagnosed cancer in north-American men. Few dietary or lifestyle interventions have been tested to prevent prostate cancer progression. Omega-3 fatty acid supplementation represents a promising intervention for prostate cancer patients. The aim of the study is to evaluate the effects of long-chain omega-3 polyunsaturated fatty acids (LCn3), more precisely eicosapentaenoic acid monoacylglyceride (MAG-EPA) supplementation, on prostate cancer proliferation, inflammation mediators and quality of life among men who will undergo radical prostatectomy...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29321043/what-is-in-your-wallet-a-cluster-randomized-trial-of-the-effects-of-showing-comparative-patient-out-of-pocket-costs-on-primary-care-prescribing-for-uncomplicated-hypertension
#9
Robyn Tamblyn, Nancy Winslade, Christina J Qian, Teresa Moraga, Allen Huang
BACKGROUND: Drug expenditures are responsible for an increasing proportion of health costs, accounting for $1.1 trillion in annual expenditure worldwide. As hundreds of billions of dollars are being spent each year on overtreatment with prescribed medications that are either unnecessary or are in excess of lowest cost-effective therapy, programs are needed that optimize fiscally appropriate use. We evaluated whether providing physicians with information on the patient out-of-pocket payment consequences of prescribing decisions that were in excess of lowest cost-effective therapy would alter prescribing decisions using the treatment of uncomplicated hypertension as an exemplar...
January 10, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29320564/a-time-lagged-effect-of-conspecific-density-on-habitat-selection-by-snowshoe-hare
#10
Toshinori Kawaguchi, André Desrochers
Ideal free distribution theory predicts that increased conspecific density redistributes individuals to low-density, suboptimal habitat. However, possible lags in response to population density remain poorly documented. Snowshoe hares (Lepus americanus) may exhibit density-dependent habitat selection due to its marked variation in population density. Based on 11 years (2004-2014) of snow tracking in Quebec (Canada), we investigated snowshoe hares' short-term and delayed habitat selection responses to population density...
2018: PloS One
https://www.readbyqxmd.com/read/29316862/-we-ve-been-here-for-2-000-years-white-settlers-native-american-dna-and-the-phenomenon-of-indigenization
#11
Darryl Leroux
Relying on a populace well-educated in family history based in ancestral genealogy, a robust national genomics sector has developed in Québec over the past decade-and-a-half. The same period roughly coincides with a fourfold increase in the number of individuals and organizations in the region self-identifying with a mixed-race form of indigeneity that is counter to existing Indigenous understandings of kinship and citizenship. This paper examines how recent efforts by genetic scientists, working on a multi-year research project on the 'diversity' of the Québec gene pool, intervene in complex settler-Indigenous relations by redefining indigeneity according to the logics of 'Native American DNA'...
January 1, 2018: Social Studies of Science
https://www.readbyqxmd.com/read/29313875/memo-efficacy-durability-and-effect-of-cognitive-training-and-psychosocial-intervention-in-individuals-with-mild-cognitive-impairment
#12
Sylvie Belleville, Carol Hudon, Nathalie Bier, Catherine Brodeur, Brigitte Gilbert, Sébastien Grenier, Marie-Christine Ouellet, Chantal Viscogliosi, Serge Gauthier
BACKGROUND/OBJECTIVES: There is no consensus on the efficacy of cognitive training in persons with mild cognitive impairment (MCI) because of the paucity of well-designed randomized controlled trials. The objective was to assess the effect of memory training on the cognitive functioning of persons with MCI and its durability and to evaluate whether this effect generalizes to daily life and whether positive effects could be obtained from psychosocial intervention. DESIGN: Single-blind randomized controlled trial...
January 4, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29310735/what-do-clinical-supervisors-require-to-teach-residents-in-family-medicine-how-to-care-for-seniors
#13
Anik M C Giguere, Paule Lebel, Michèle Morin, Françoise Proust, Charo Rodríguez, Valerie Carnovale, Louise Champagne, France Légaré, Pierre-Hugues Carmichael, Bernard Martineau, Philippe Karazivan, Pierre J Durand
We assessed clinicians' continuing professional development (CPD) needs at family practice teaching clinics in the province of Quebec. Our mixed methodology design comprised an environmental scan of training programs at four family medicine departments, an expert panel to determine priority clinical situations for senior care, a supervisors survey to assess their perceived CPD needs, and interviews to help understand the rationale behind their needs. From the environmental scan, the expert panel selected 13 priority situations...
January 9, 2018: Canadian Journal on Aging, la Revue Canadienne du Vieillissement
https://www.readbyqxmd.com/read/29306500/nurses-perspectives-on-whether-medical-aid-in-dying-should-be-accessible-to-incompetent-patients-with-dementia-findings-from-a-survey-conducted-in-quebec-canada
#14
G Bravo, C Rodrigue, M Arcand, J Downie, M-F Dubois, S Kaasalaine, C M Hertogh, S Pautex, L Van den Block
We conducted a survey in a random sample of 514 Quebec nurses caring for the elderly to assess their attitudes towards extending medical aid in dying to incompetent patients and to explore associated factors. Attitudes were measured using clinical vignettes featuring a hypothetical patient with Alzheimer disease. Vignettes varied according to the stage of the disease (advanced or terminal) and the presence or absence of a written request. Of the 291 respondents, 83.5% agreed with the current legislation that allows physicians to administer aid in dying to competent patients who are at the end of life and suffer unbearably...
January 3, 2018: Geriatric Nursing
https://www.readbyqxmd.com/read/29304227/combining-environmental-investigation-and-a-dual-analytical-strategy-to-isolate-the-legionella-longbeachae-strain-linked-to-two-occupational-cases-of-legionellosis
#15
Genevieve Marchand, Judith Lord, Carole Pépin, Nancy Lacombe
Legionella has a global distribution, mainly in aquatic and man-made environments. Under the right conditions, this bacterium is a notorious human pathogen responsible for severe pulmonary illnesses. Legionellosis outbreaks are reported around the world, and exposure to water droplet aerosols containing Legionella pneumophila is usually the mechanism of its transmission. Even if L. pneumophila causes most outbreaks, Legionella longbeachae also accounts for some cases. Unlike most other Legionella strains, L...
January 3, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29302103/babesia-odocoilei-as-a-cause-of-mortality-in-captive-cervids-in-canada
#16
Amélie Mathieu, Adriana R Pastor, Charlene N Berkvens, Carolyn Gara-Boivin, Michel Hébert, Alexandre N Léveillé, John R Barta, Dale A Smith
Nine cases of fatal infection with Babesia odocoilei were confirmed in reindeer (Rangifer tarandus tarandus) and elk (Cervus canadensis) housed in zoological institutions located in southern Quebec, Ontario, and Manitoba, Canada between 2013 and 2016. All animals died of a hemolytic crisis. Frequent postmortem findings were extensive hemorrhage, pigmenturia, and intrahepatic cholestasis. The described ante- and postmortem signs are consistent with those of previously reported cases in the United States. Diagnosis was confirmed in all cases by polymerase chain reaction performed on DNA extracted from whole blood or frozen spleen...
January 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29300870/thermal-acclimation-of-photosynthesis-and-respiration-of-southern-and-northern-white-spruce-seed-sources-tested-along-a-regional-climatic-gradient-indicates-limited-potential-to-cope-with-temperature-warming
#17
Lahcen Benomar, Mohammed S Lamhamedi, Steeve Pepin, André Rainville, Marie-Claude Lambert, Hank A Margolis, Jean Bousquet, Jean Beaulieu
Background and Aims: Knowledge of thermal acclimation of physiological processes of boreal tree species is necessary to determine their ability to adapt to predicted global warming and reduce the uncertainty around the anticipated feedbacks of forest ecosystems and global carbon cycle to climate change. The objective of this work was to examine the extent of thermal acclimation of net photosynthesis (An) and dark respiration (Rd) of two distant white spruce (Picea glauca) seed sources (from south and north of the commerial forest zone in Québec) in response to latitudinal and seasonal variations in growing conditions...
December 29, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29300783/the-economic-benefits-of-reducing-cardiovascular-disease-mortality-in-quebec-canada
#18
David Boisclair, Yann Décarie, François Laliberté-Auger, Pierre-Carl Michaud, Carole Vincent
OBJECTIVES: We assess how different scenarios of cardiovascular disease (CVD) prevention, aimed at meeting targets set by the World Health Organization (WHO) for 2025), may impact healthcare spending in Quebec, Canada over the 2050 horizon. METHODS: We provide long-term forecasts of healthcare use and costs at the Quebec population level using a novel dynamic microsimulation model. Using both survey and administrative data, we simulate the evolution of the Quebec population's health status until death, through a series of dynamic transitions that accounts for social and demographic characteristics associated with CVD risk factors...
2018: PloS One
https://www.readbyqxmd.com/read/29299979/communities-being-well-for-family-well-being-exploring-the-socio-ecological-determinants-of-well-being-in-an-inuit-community-of-northern-quebec
#19
Sarah L Fraser, Valérie Parent, Véronique Dupéré
Inuit communities of Canada experience many disparities in health and psychosocial context. Research in community psychology has shown associations between such socio-ecological factors and individual well-being. The objective of the study was to explore how community-level determinants of well-being influence family well-being in a northern community of Nunavik, Quebec. A total of 14 participants were interviewed. A thematic inductive analysis was conducted to extract community determinants of family well-being from the data...
January 1, 2018: Transcultural Psychiatry
https://www.readbyqxmd.com/read/29298995/nuclear-receptor-gene-polymorphisms-and-warfarin-dose-requirements-in-the-quebec-warfarin-cohort
#20
Payman Shahabi, Félix Lamothe, Stéphanie Dumas, Étienne Rouleau-Mailloux, Yassamin Feroz Zada, Sylvie Provost, Geraldine Asselin, Ian Mongrain, Diane Valois, Marie-Josée Gaulin Marion, Louis-Philippe Lemieux Perreault, Sylvie Perreault, Marie-Pierre Dubé
Warfarin is primarily metabolized by cytochrome 2C9, encoded by gene CYP2C9. Here, we investigated whether variants in nuclear receptor genes which regulate the expression of CYP2C9 are associated with warfarin response. We used data from 906 warfarin users from the Quebec Warfarin Cohort (QWC) and tested the association of warfarin dose requirement at 3 months following the initiation of therapy in nine nuclear receptor genes: NR1I3, NR1I2, NR3C1, ESR1, GATA4, RXRA, VDR, CEBPA, and HNF4A. Three correlated SNPs in the VDR gene (rs4760658, rs11168292, and rs11168293) were associated with dose requirements of warfarin (P = 2...
January 3, 2018: Pharmacogenomics Journal
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