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https://www.readbyqxmd.com/read/29453435/evidence-of-a-gene-environment-interaction-of-nodal-variants-and-inflammation-in-preterm-birth
#1
Lisa M Starr, Taghreed Heba, Daniel Dufort
OBJECTIVE: NODAL has been implicated in timing of parturition and immune regulation. We investigated the relationship between NODAL polymorphisms, infection/inflammation, and preterm birth. STUDY DESIGN: For this secondary analysis, 613 women (189 preterm and 424 term) from the Montreal Prematurity Study were genotyped for NODAL polymorphisms and assessed for bacterial vaginosis and placental inflammation. RESULT: NODAL polymorphisms were not associated with preterm birth...
February 16, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29444740/associations-between-modifiable-lifestyle-factors-and-multidimensional-cognitive-health-among-community-dwelling-old-adults-stratified-by-educational-level
#2
Manqiong Yuan, Jia Chen, Yaofeng Han, Xingliang Wei, Zirong Ye, Liangwen Zhang, Y Alicia Hong, Ya Fang
BACKGROUND: Cognition is multidimensional, and each domain plays a unique and crucial part in successful daily life engagement. However, less attention has been paid to multi-domain cognitive health for the elderly, and the role of lifestyle factors in each domain remains unclear. METHODS: We conducted a cross-sectional study of 3,230 older adults aged 60+ years in Xiamen, China, in 2016. The Montreal Cognitive Assessment (MoCA) was used to measure general cognition and six specific sub-domains...
February 15, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29443486/effects-on-patients-of-variations-in-the-implementation-of-a-cardiometabolic-risk-intervention-program-in-montr%C3%A3-al
#3
Marie-Ève Beauregard, Sylvie Provost, Raynald Pineault, Dominique Grimard, José Pérez, Michel Fournier
INTRODUCTION: In 2011, the Agence de la santé et des services sociaux de Montréal (ASSSM), in partnership with the region's Centres de santé et de services sociaux (CSSS), coordinated the implementation of a program on cardiometabolic risk based on the Chronic Care Model. The program, intended for patients suffering from diabetes or hypertension, involved a series of individual follow-up appointments, group classes and exercise sessions. Our study assesses the impact on patient health outcomes of variations in the implementation of some aspects of the program among the six CSSSs taking part in the study...
February 2018: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29439581/association-between-dementia-severity-and-recommended-lifestyle-changes-a-retrospective-cohort-study
#4
Timothy Thoits, Alison Dutkiewicz, Sarah Raguckas, Michael Lawrence, Jessica Parker, Jacob Keeley, Nicholas Andersen, Martha VanDyken, Maegan Hatfield-Eldred
OBJECTIVE: Early diagnosis of dementia leads to early treatment which is beneficial to patients and the community. We reviewed initial evaluations from the Spectrum Health Medical Group Neurocognitive Clinic (SHMGNC) to evaluate dementia stage at the time of diagnosis. METHODS: We retrospectively reviewed 110 randomly chosen initial evaluations from September 2008 to December 2015 at the SHMGNC. Patients underwent a neurological examination, Montreal Cognitive Assessment, and a battery of neuropsychological testing...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29439349/comparing-the-electronic-and-standard-versions-of-the-montreal-cognitive-assessment-in-an-outpatient-memory-disorders-clinic-a-validation-study
#5
Jody-Lynn Berg, January Durant, Gabriel C Léger, Jeffrey L Cummings, Ziad Nasreddine, Justin B Miller
The Montreal Cognitive Assessment (MoCA) has become widely used as a brief test of cognitive function in patients with neurological disease. More convenient application of the MoCA might increase its use and enhance its utility. An electronic version of the MoCA has recently been developed. To establish validity of the electronic version (eMoCA), discrepancy scores, concordance correlation coefficients (CCC), and root mean squared differences (RMSD) were calculated between each administration method in a sample of 43 new adult patients presenting with primary memory complaints...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29439344/low-accuracy-of-brief-cognitive-tests-in-tracking-longitudinal-cognitive-decline-in-an-asian-elderly-cohort
#6
April Ka Sin Phua, Shaun Kuan Wei Hiu, Win King Goh, Mohammad Kamran Ikram, Narayanaswamy Venketasubramanian, Boon Yeow Tan, Christopher Li-Hsian Chen, Xin Xu
BACKGROUND: Researchers have questioned the utility of brief cognitive tests such as the Mini-Mental Status Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) in serial administration and suggested that brief cognitive tests may not accurately track changes in Global Cognition. OBJECTIVE: To examine the accuracy of longitudinal changes on brief cognitive tests in reflecting progression in Global Cognition measured using comprehensive neuropsychological assessments...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29439251/low-cerebral-oxygenation-is-associated-with-cognitive-impairment-in-chronic-hemodialysis-patients
#7
Lucie Kovarova, Anna Valerianova, Tereza Kmentova, Jana Lachmanova, Zuzana Hladinova, Jan Malik
BACKGROUND/AIMS: High rates of cognitive impairment (CI) are an alarming problem in patients undergoing chronic hemodialysis (HD). Its pathophysiology remains unclear and there are indications that brain ischemia might be one of the key causes. Cerebral tissue oxygenation, as measured by near-infrared spectroscopy, is known to be decreased in HD patients. However, it is unknown whether CI is associated or not associated with lower cerebral oxygenation in these patients. The primary aim of our study was to probe this possible association...
February 13, 2018: Nephron
https://www.readbyqxmd.com/read/29439084/evaluating-the-impact-of-type-2-diabetes-mellitus-on-cyp450-metabolic-activities-protocol-for-a-case-control-pharmacokinetic-study
#8
Sophie Gravel, Jean-Louis Chiasson, Suzanne Dallaire, Jacques Turgeon, Veronique Michaud
INTRODUCTION: Diabetes affects more than 9% of the adult population worldwide. Patients with type 2 diabetes mellitus (T2DM) show variable responses to some drugs which may be due, in part, to variability in the functional activity of drug-metabolising enzymes including cytochromes P450 (CYP450s). CYP450 is a superfamily of enzymes responsible for xenobiotic metabolism. Knowledge must be gained on the impact of T2DM and related inflammatory processes on drug metabolism and its consequences on drug response...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29436078/multisensory-exercise-programme-improves-cognition-and-functionality-in-institutionalized-older-adults-a-randomized-control-trial
#9
Natália Boneti Moreira, Gabriele Gonçalves, Talihina da Silva, Francisco Ernesto Halila Zanardini, Paulo Cesar Barauce Bento
AIM: The aim of this study was to verify the effects of a multisensory exercise programme on the cognition and functionality of institutionalized older adults. METHODS: Forty-five volunteers were randomly allocated to 2 groups, the multisensory exercise programme (n = 24) and the control group that received no treatment (n = 21). The programme consisted of 3 50-min sessions of progressive exercises per week for 16 weeks that challenged their strength, balance, coordination, multisensory stimulation, and flexibility in different tasks...
February 13, 2018: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
https://www.readbyqxmd.com/read/29434777/effects-of-donepezil-on-cognitive-functions-and-the-expression-level-of-%C3%AE-amyloid-in-peripheral-blood-of-patients-with-alzheimer-s-disease
#10
Yunxia Ma, Jinming Ji, Gang Li, Shuzhen Yang, Shuangshuang Pan
Alzheimer's disease is a degenerative disease affecting the central nervous system for which donepezil is usually prescribed. The aim of the present study was to examine the effects of donepezil on the cognitive functions and expression levels of β-amyloid (Aβ) in the peripheral blood of patients with Alzheimer's disease. In total, 76 patients with cognitive impairment, who visited the Department of Neurology of Binzhou City Center Hospital from June 2015 to September 2016, had memory decline for more than three consecutive months and underwent mini-mental state examination (MMSE) score screening, were selected for the study...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29433603/is-distance-to-the-nearest-registered-public-automated-defibrillator-associated-with-the-probability-of-bystander-shock-for-victims-of-out-of-hospital-cardiac-arrest
#11
Joel Neves Briard, Luc de Montigny, Dave Ross, François de Champlain, Eli Segal
Introduction Rapid access to defibrillation is a key element in the management of out-of-hospital cardiac arrests (OHCAs). Public automated external defibrillators (PAEDs) are becoming increasingly available, but little information exists regarding the relation between the proximity to the arrest and their usage in urban areas. METHODS: This study is a retrospective, observational, cross-sectional analysis of non-traumatic OHCA during a 24-month period in the greater Montreal area (Quebec, Canada)...
February 13, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29433018/interaction-between-deca-bde-and-hepatic-deiodinase-in-a-highly-pbde-exposed-bird
#12
Anthony François, Jonathan Verreault
Studies have shown that debromination of the major component in the deca-brominated diphenyl ether mixture (deca-BDE), BDE-209, occurs in vivo in birds. Recent work from our laboratory on breeding ring-billed gulls (Larus delawarensis) exposed to elevated PBDE concentrations in the densely-populated metropolis of Montreal (Canada) further suggests that BDE-209 debromination is potentially catalyzed by deiodinases in liver microsomes. The first objective of this study was to determine if type 1 deiodinase (D1) was involved in the in vitro debromination of BDE-209 in liver microsomes of ring-billed gulls...
February 9, 2018: Environmental Research
https://www.readbyqxmd.com/read/29432524/reimplantation-versus-remodelling-with-ring-annuloplasty-comparison-of-mid-term-outcomes-after-valve-sparing-aortic-root-replacement
#13
Marien Lenoir, Bart Maesen, Louis-Mathieu Stevens, Raymond Cartier, Philippe Demers, Nancy Poirier, Michaël Tousch, Ismail El-Hamamsy
OBJECTIVES: Remodelling with extra-aortic ring annuloplasty has emerged as an alternative approach to root reimplantation. However, no studies have yet compared outcomes between procedures. The aim of this study was to compare mid-term outcomes in patients undergoing reimplantation versus remodelling with extra-aortic annuloplasty. METHODS: From 2001 to 2017, 142 patients underwent root remodelling with extra-aortic annuloplasty (n = 83, 48 ± 13 years) or a reimplantation technique (n = 59, 48 ± 12 years) at the Montreal Heart Institute...
February 8, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29431126/repetitive-transcranial-magnetic-stimulation-for-depression-after-basal-ganglia-ischaemic-stroke-protocol-for-a-multicentre-randomised-double-blind-placebo-controlled-trial
#14
Ying Tang, Aimin Chen, Shuzhen Zhu, Li Yang, Jiyuan Zhou, Suyue Pan, Min Shao, Lianxu Zhao
INTRODUCTION: Studies suggest that repetitive transcranial magnetic stimulation (rTMS) is effective for the treatment of depression and promotes the repair of white matter. This study aims to assess the effectiveness of rTMS in treating depression after basal ganglia ischaemic stroke and to examine whether such effects are related to restoration of white matter integrity. METHODS AND ANALYSIS: Sixty-six participants will be recruited from Zhujiang Hospital, Nanfang Hospital and Sichuan Bayi Rehabilitation Hospital and randomised in a 1:1 ratio to receive active rTMS treatment or sham rTMS treatment in addition to routine supportive treatments...
February 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29430766/normative-data-for-the-montreal-cognitive-assessment-moca-and-the-memory-index-score-moca-mis-in-brazil-adjusting-the-nonlinear-effects-of-education-with-fractional-polynomials
#15
Daniel Apolinario, Marília Funchal Dos Santos, Eduardo Sassaki, Fernanda Pegoraro, Anna Vitoria Alves Pedrini, Bruna Cestari, Ana Helena Amaral, Mayra Mitt, Marina Bellatti Müller, Claudia Kimie Suemoto, Ivan Aprahamian
No abstract text is available yet for this article.
February 12, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29430590/patterns-of-health-care-service-utilization-by-individuals-with-mental-health-problems-a-predictive-cluster-analysis
#16
Béatrice Simo, Jean-Marie Bamvita, Jean Caron, Marie-Josée Fleury
This study aimed at identifying and characterizing clusters of mental health service users based on various characteristics in a sample of individuals with mental health problems. Data were collected in the epidemiological catchment area of South-West Montreal, Quebec in 2011 and 2014. Among the 746 participants who reported experiencing a mental health problem (high psychological distress and/or a mental disorder), 29% had used mental health services. A Two-Step cluster analysis was carried out to generate participant profiles based on their visit to mental health professional...
February 12, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29428545/the-montreal-children-s-hospital-feeding-scale-relationships-with-parental-report-of-child-eating-behaviours-and-observed-feeding-interactions
#17
Samantha Rogers, Maria Ramsay, Jackie Blissett
Feeding problems are common, with implications for nutrition, growth and family stress, placing burden on primary care services. The Montreal Children's Hospital Feeding Scale (MCHFS) is a quick and reliable measure of feeding problems for clinical settings, but there is little examination of its relationship to commonly used research measures of parental feeding practice, child eating behaviour and observations of parent-infant interaction at mealtimes. We examined the relationships between the MCHFS, demographics and early feeding history, weight across the first year, parental report of feeding practices and child eating behaviours, and observations of maternal-infant feeding interaction at 1 year...
February 8, 2018: Appetite
https://www.readbyqxmd.com/read/29427575/rhythm-perception-and-production-abilities-and-their-relationship-to-gait-after-stroke
#18
Kara K Patterson, Jennifer S Wong, Svetlana Knorr, Jessica A Grahn
OBJECTIVES: To assess rhythm abilities, describe their relationship to clinical presentation, and to determine if rhythm production independently contributes to temporal gait asymmetry post-stroke. DESIGN: Cross-sectional. SETTING: Large urban rehabilitation hospital and university. PARTICIPANTS: Individuals with subacute and chronic stroke (n=39) and data for healthy adults extracted from a pre-existing database (n=21)...
February 7, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29427168/diagnostic-test-accuracy-of-the-montreal-cognitive-assessment-in-the-detection-of-post-stroke-cognitive-impairment-under-different-stages-and-cutoffs-a-systematic-review-and-meta-analysis
#19
Dan Shi, Xiao Chen, Zheng Li
The purposes of this review were to give the optimal cutoffs of the Montreal Cognitive Assessment (MoCA) by comparing sensitivity and specificity under different cutoffs and compare the MoCA with other screening tools in post-stroke cognitive impairment (PSCI) determined by a neuropsychological evaluation. Articles were derived from a systematic search in PubMed, Web of science, Embase, and CINAHL and were assessed for internal validity by the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). The figure of risk of bias was made by Review Manager 5...
February 9, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29426436/prospective-case-control-trial-evaluating-silicone-gel-for-the-treatment-of-direct-brow-lift-scars
#20
Nicolas Cadet, Isabelle Hardy, Diana Dudek, Krystyna Miszkiewicz, Patrick Boulos, Quyhn Nguyen, Jamie Wong
OBJECTIVE: To evaluate the effectiveness of a topical silicone gel on scars in patients who had undergone bilateral direct brow lift surgery. DESIGN: A randomized double-blind clinical trial with a placebo applied to one scar and topical silicone gel (Dermatix Ultra; Valeant Pharmaceuticals, Laval, Que.) used on the other scar for 2 months. PARTICIPANTS: Twelve patients (for a total of 24 surgical scars evaluated) were included in the study...
February 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
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