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https://www.readbyqxmd.com/read/28530526/warfarin-management-and-outcomes-in-patients-with-nonvalvular-atrial-fibrillation-within-an-integrated-health-care-system
#1
JaeJin An, Fang Niu, Chengyi Zheng, Nazia Rashid, Robert A Mendes, Diana Dills, Lien Vo, Prianka Singh, Amanda Bruno, Daniel T Lang, Paul T Le, Kristin P Jazdzewski, Gustavus Aranda
BACKGROUND: Warfarin is a common treatment option to manage patients with nonvalvular atrial fibrillation (NVAF) in clinical practice. Understanding current pharmacist-led anticoagulation clinic management patterns and associated outcomes is important for quality improvement; however, currently little evidence associating outcomes with management patterns exists. OBJECTIVES: To (a) describe warfarin management patterns and (b) evaluate associations between warfarin treatment and clinical outcomes for patients with NVAF in an integrated health care system...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28528589/traumatic-brain-injury-in-the-workplace
#2
Michael Paci, Claire Infante-Rivard, Judith Marcoux
OBJECTIVES: Work-related traumatic brain injuries (TBIs) are not well documented in the literature. Published studies mostly rely on worker databases that fail to provide clinically relevant information. Our objective is to describe the characteristics of hospitalized patients and their work-related TBI. METHODS: We used the Québec provincial trauma and TBI program databases to identify all patients with a diagnosis of work-related TBI admitted to the Montreal General Hospital, a level 1 trauma center, between 2000 and 2014...
May 22, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28528357/cerebellar-gray-matter-alterations-in-huntington-disease-a-voxel-based-morphometry-study
#3
Paula C de Azevedo, Rachel P Guimarães, Camila C Piccinin, Luiza G Piovesana, Lidiane S Campos, Juliana R Zuiani, Eliza M Tamashiro, Giordanna Pinheiro, Augusto C Amato-Filho, Fernando Cendes, Iscia Lopes-Cendes, Anelyssa D'Abreu
Neuropathological and neuroimaging studies in Huntington disease (HD) have suggested a role for the cerebellum. Our goal was to perform a detailed evaluation of cerebellar morphology. We performed the Unified HD rating scale (UHDRS) and Montreal cognitive assessment (MOCA) in 26 HD patients and 26 healthy controls. We created a two-sample test to analyze cerebellar gray matter (GM) differences between groups and another to correlate GM alterations with UHDRS and MOCA, corrected for age, expanded cytosine-adenine-guanine repeats, and disease duration using the spatially unbiased atlas template (SUIT)-SPM-toolbox which preserves anatomical detailing...
May 20, 2017: Cerebellum
https://www.readbyqxmd.com/read/28528240/negative-correlation-between-csf-lactate-levels-and-moca-scores-in-male-chinese-subjects
#4
Haijun Wang, Xiaohua Tan, Jinzhong Xu, Hui Li, Meiling Wang, Suling Chen, Xiaoyu Yang, Yanlong Liu, Fan Wang
Lactate is a product of glycolysis by astrocytes and can be generated as a primary metabolic energy source by neurons. Lactate plays multifunctional role in human brain energy metabolism and cognitive function. However, no direct evidence demonstrated the link between lactate and cognition in normal condition. In the present study, concentrations of lactate in cerebrospinal fluid (CSF) and peripheral blood were measured to investigate the association of lactate with cognitive ability, which was assessed by Montreal Cognitive Assessment (MoCA), in 99 male Chinese subjects...
May 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28526295/large-scale-exploratory-genetic-analysis-of-cognitive-impairment-in-parkinson-s-disease
#5
Ignacio F Mata, Catherine O Johnson, James B Leverenz, Daniel Weintraub, John Q Trojanowski, Vivianna M Van Deerlin, Beate Ritz, Rebecca Rausch, Stewart A Factor, Cathy Wood-Siverio, Joseph F Quinn, Kathryn A Chung, Amie L Peterson-Hiller, Alberto J Espay, Fredy J Revilla, Johnna Devoto, Dora Yearout, Shu-Ching Hu, Brenna A Cholerton, Thomas J Montine, Karen L Edwards, Cyrus P Zabetian
Cognitive impairment is a common and disabling problem in Parkinson's disease (PD). Identification of genetic variants that influence the presence or severity of cognitive deficits in PD might provide a clearer understanding of the pathophysiology underlying this important nonmotor feature. We genotyped 1105 PD patients from the PD Cognitive Genetics Consortium for 249,336 variants using the NeuroX array. Participants underwent assessments of learning and memory (Hopkins Verbal Learning Test-Revised [HVLT-R]), working memory/executive function (Letter-Number Sequencing and Trail Making Test [TMT] A and B), language processing (semantic and phonemic verbal fluency), visuospatial abilities (Benton Judgment of Line Orientation [JoLO]), and global cognitive function (Montreal Cognitive Assessment)...
April 20, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28521729/self-rated-health-and-functional-capacity-in-individuals-reporting-overlapping-symptoms-of-gastroesophageal-reflux-disease-functional-dyspepsia-and-irritable-bowel-syndrome-a-population-based-study
#6
Dorte Ejg Jarbøl, Sanne Rasmussen, Kirubakaran Balasubramaniam, Sandra Elnegaard, Peter Fentz Haastrup
BACKGROUND: Gastroesophageal reflux disease (GERD), functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common functional gastrointestinal conditions with a significant impact on daily life. The objectives were to analyse general self-rated health and self-reported functional capacity in adults meeting the criteria for GERD, FD and IBS, respectively, and in individuals who meet the criteria for more than one of the conditions. METHODS: A nationwide study of 100,000 individuals aged 20 years and above, randomly selected in the general Danish population...
May 18, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28520873/association-between-neurocognitive-decline-and-visual-field-variability-in-glaucoma
#7
Alberto Diniz-Filho, Lisa Delano-Wood, Fábio B Daga, Sebastião Cronemberger, Felipe A Medeiros
Importance: Visual field variability may impair detection of glaucoma progression over time. Despite the possible overlap between neurocognitive disorders and glaucoma in older individuals, no study has investigated the association between cognitive changes and visual field variability. Objective: To evaluate the association between global neurocognitive impairment and visual field variability in patients diagnosed as having glaucoma or glaucoma suspects. Design, Setting, and Participants: This prospective observational cohort study was conducted at the Visual Performance Laboratory, University of California, San Diego...
May 18, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28520804/inpatient-z-drug-use-commonly-exceeds-safe-dosing-recommendations
#8
Todd C Lee, André Bonnici, Robyn Tamblyn, Emily G McDonald
IMPORTANCE: In 2016 recommendations for safer prescribing practices were circulated to all doctors in one of Canada's largest provinces, by the college of physicians, following a coroner's inquest into a vehicular death related to Z-drug use. We sought to determine how frequently Z-drug prescriptions in our institution were not adhering to these recommendations. DESIGN: Retrospective cohort study. SETTING: McGill University Health Centre, an 832-bed tertiary care institution in Montréal, Canada...
2017: PloS One
https://www.readbyqxmd.com/read/28515807/external-validation-of-the-procars-nomograms-and-comparison-of-existing-risk-stratification-tools-for-localized-prostate-cancer
#9
David Tiberi, George Rodrigues, Tom Pickles, Jim Morris, Juanita Crook, Andre-Guy Martin, Fabio Cury, Charles Catton, Himu Lukka, Andrew Warner, Daniel Taussky
INTRODUCTION: The purpose of this study was to perform a direct comparison of several existing risk-stratification tools for localized prostate cancer in terms of their ability to predict for biochemical failure-free survival (BFFS). Two large databases were used and an external validation of two recently developed nomograms on an independent cohort was also performed in this analysis. METHODS: Patients who were treated with external beam radiotherapy (EBRT) and/or brachytherapy for localized prostate cancer were selected from the multi-institutional Genitourinary Radiation Oncologists of Canada (GUROC) Prostate Cancer Risk Stratification (ProCaRS) database (n=7974) and the Centre Hospitalier de l'Université de Montréal (CHUM) validation database (n=2266)...
March 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28514669/the-relationship-between-cognition-and-depressive-symptoms-and-factors-modifying-this-association-in-alzheimer-s-disease-a-multivariate-multilevel-model
#10
Bei Yang, Hongmei Yu, Min Xing, Runlian He, Ruifeng Liang, Liye Zhou
OBJECTIVES: To examine whether there was a bidirectional association between cognition and depressive symptoms in Alzheimer's disease (AD), and to explore the role of socio-demographic factors and daily performance in this association. METHODS: We conducted a longitudinal study of 104 community-dwelling patients with confirmed AD from Taiyuan, China. We assessed cognition and depressive symptoms (dependent variables) with the Montreal Cognitive Assessment (MoCA) and the Geriatric Depression Scale-30 (GDS-30), respectively...
May 10, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28511984/comparison-of-three-cognitive-exams-in-cardiac-arrest-survivors
#11
Allison C Koller, Jon C Rittenberger, Melissa J Repine, Patrick W Morgan, Jeffrey Kristan, Clifton W Callaway
BACKGROUND: Cognitive deficits may detract from quality of life after cardiac arrest. Their pattern and prevalence are not well documented. We used the Computer Assessment of Mild Cognitive Impairment (CAMCI), the Montreal Cognitive Assessment (MOCA) and the 41 Cent Test (41CT) to assess cognitive impairment in cardiac arrest survivors and examine the exams' diagnostic accuracy. We hypothesized that the scores of these exams would indicate the presence of cognitive impairment in arrest survivors, that the overall scores on the three study assessments would correlate with one another, and that the 41CT, MOCA, and executive function element of the CAMCI would vary independently from other non-executive CAMCI components, reflecting executive function impairment after cardiac arrest...
May 13, 2017: Resuscitation
https://www.readbyqxmd.com/read/28510618/auditory-processing-of-older-adults-with-probable-mild-cognitive-impairment
#12
Jerri D Edwards, Jennifer J Lister, Maya N Elias, Amber M Tetlow, Angela L Sardina, Nasreen A Sadeq, Amanda D Brandino, Aryn L Harrison Bush
Purpose: Studies suggest that deficits in auditory processing predict cognitive decline and dementia, but those studies included limited measures of auditory processing. The purpose of this study was to compare older adults with and without probable mild cognitive impairment (MCI) across two domains of auditory processing (auditory performance in competing acoustic signals and temporal aspects of audition). Method: The Montreal Cognitive Assessment (Nasreddine et al...
May 16, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28505977/hippocampal-and-clinical-trajectories-of-mild-cognitive-impairment-with-suspected-non-alzheimer-s-disease-pathology
#13
Jun Ku Chung, Eric Plitman, Shinichiro Nakajima, Fernando Caravaggio, Yusuke Iwata, Philip Gerretsen, Julia Kim, Hiroyoshi Takeuchi, Shunichiro Shinagawa, Raihaan Patel, M Mallar Chakravarty, Ariel Graff-Guerrero
Suspected non-Alzheimer's disease pathophysiology (SNAP) characterizes individuals showing neurodegeneration (e.g., hypometabolism) without amyloid-β (Aβ). Findings from previous studies regarding clinical and structural trajectories of SNAP are inconsistent. Using data from the Alzheimer's Disease Neuroimaging Initiative, patients with amnestic mild cognitive impairment (MCI) were categorized into four groups: amyloid positive with hypometabolism (Aβ+ND+), amyloid only (Aβ+ND-), neither amyloid nor hypometabolism (Aβ-ND-), and SNAP (Aβ-ND+)...
May 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28503706/an-eye-tracker-controlled-cognitive-battery-overcoming-verbal-motor-limitations-in-als
#14
Barbara Poletti, Laura Carelli, Federica Solca, Annalisa Lafronza, Elisa Pedroli, Andrea Faini, Nicola Ticozzi, Andrea Ciammola, Paolo Meriggi, Pietro Cipresso, Dorothée Lulé, Albert C Ludolph, Giuseppe Riva, Vincenzo Silani
We assessed language, attention, executive, and social cognition abilities in a sample of patients with Amyotrophic Lateral Sclerosis (ALS) by means of a recently developed cognitive battery based on oculomotor control with eye-tracking (ET) technology. Twenty-one ALS patients and 21 age- and education-matched healthy subjects underwent the ET-based cognitive assessment, together with the standard cognitive screening tools [Frontal Assessment Battery (FAB); Montreal Cognitive Assessment (MoCA); and Digit Sequencing Task]...
May 13, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28500477/impact-of-a-program-for-the-management-of-aggressive-behaviors-on-seclusion-and-restraint-use-in-two-high-risk-units-of-a-mental-health-institute
#15
Steve Geoffrion, Jane Goncalves, Charles-Édouard Giguère, Stéphane Guay
The Omega Program for the Management of Aggressive Behaviors aims to reduce patients' dangerous behaviors, towards themselves or others, and to reduce the use of seclusion and restraint (S/R). A previous study in a Mental Health Institute (Montreal, Canada) showed that implementing this program allowed employees of the intensive care and emergency units to gain confidence in coping with patients' aggressions and to reduce their psychological distress. The present study, conducted in the same high-risk units, assesses the effect of the program on S/R use...
May 13, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28499360/prevalence-and-correlates-of-cognitive-impairment-in-kidney-transplant-recipients
#16
Aditi Gupta, Jonathan D Mahnken, David K Johnson, Tashra S Thomas, Dipti Subramaniam, Tyler Polshak, Imran Gani, G John Chen, Jeffrey M Burns, Mark J Sarnak
BACKGROUND: There is a high prevalence of cognitive impairment in dialysis patients. The prevalence of cognitive impairment after kidney transplantation is unknown. METHODS: Study Design: Cross-sectional study. SETTING AND PARTICIPANTS: Single center study of prevalent kidney transplant recipients from a transplant clinic in a large academic center. INTERVENTION: Assessment of cognition using the Montreal Cognitive Assessment (MoCA)...
May 12, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28499302/-virtual-planning-of-prosthetic-treatment-of-the-orbit
#17
Johannes A Veit, Julia Thierauf, Kornelius Egner, Severin Wiggenhauser, Daniel Friedrich, Jens Greve, Patrick J Schuler, Thomas K Hoffmann, Alexander Schramm
Optimal positioning of bone-anchored implants in the treatment of patients with orbital prosthesis is challenging. The definition of implant axis as well as the positioning of the implants is important to prevent failures in prosthetic rehabilitation in these patients. We performed virtual planning of enossal implants at a base of a standard fan beam CT scan using the software CoDiagnostiX™ (DentalWings, Montréal, Canada). By 3D-printing a surgical guide for drilling and implant insertion was manufactured (Med-610™, Stratasys, Rehovot, Israel)...
May 12, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28499281/assortativity-and-mixing-by-sexual-behaviors-and-sociodemographic-characteristics-in-young-adult-heterosexual-dating-partnerships
#18
Talía Malagón, Ann Burchell, Mariam El-Zein, Pierre-Paul Tellier, François Coutlée, Eduardo L Franco
BACKGROUND: Assortative sexual mixing, the tendency for individuals to choose partners with similar characteristics to themselves, may be an important contributor to the unequal distribution of sexually transmitted infections in populations. We analyzed the tendency for assortative mixing on demographic and sexual behaviors characteristics in newly formed young adults dating partnerships. METHODS: Women aged 18 to 24 years and their male sexual partners of no more than 6 months were recruited during 2005 to 2010 at universities in Montreal, Canada...
June 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28496527/correlation-between-symptom-severity-and-health-related-life-quality-of-a-population-with-gastroesophageal-reflux-disease
#19
Shou-Wu Lee, Teng-Yu Lee, Han-Chung Lien, Yen-Chun Peng, Hong-Jeh Yeh, Chi-Sen Chang
BACKGROUND: Gastroesophageal reflux disease (GERD) is a chronic disease with a negative impact on the quality of life. The aim of this study was to investigate the reflux symptoms and the health-related quality of life in a population with GERD. METHODS: Data from patients with GERD, according to the Montreal definition, were collected between January and December 2009. The enrolled patients were classified by different reflux symptoms according to the modified Chinese GERDQ...
April 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28496351/fatigue-in-patients-with-inflammatory-bowel-disease-is-associated-with-distinct-differences-in-immune-parameters
#20
Lauran Vogelaar, Colin de Haar, Bas Rj Aerts, Maikel P Peppelenbosch, Reinier Timman, Bettina E Hanssen, C Janneke van der Woude
BACKGROUND: Although it is well recognized that fatigue is an important problem in many of the quiescent inflammatory bowel disease (IBD) patients, it is unknown whether the immune status is different in fatigued versus non-fatigued patients. In this study, we contrasted various characteristics of the immune system in fatigued against non-fatigued patients with IBD in clinical remission. PATIENTS AND METHODS: Patients with IBD in clinical remission were phenotyped according to the Montreal classification, and the checklist individual strength-fatigue (CIS-fatigue) was used to assess fatigue (CIS-fatigue ≥ 35)...
2017: Clinical and Experimental Gastroenterology
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