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https://www.readbyqxmd.com/read/28863872/decision-making-in-fecal-occult-blood-test-compliance-a-quali-quantitative-study-investigating-motivational-processes
#1
G Broc, B Denis, J-B Fassier, I Gendre, P Perrin, B Quintard
The qualitative-quantitative study investigates the co-existence of barriers and levers to FOBT screening in 5894 individuals reluctant to be screened, identifying operational motivational patterns that may increase screening compliance. Co-occurrence analysis was performed according to three motivational conditions (barriers, levers, or both).Cluster analysis then identified motivational predictors of effective screening. One quarter of the individuals who had refused screening nevertheless expressed at least one motivation towards FOBT...
August 31, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28698274/noroviruses-co-opt-the-function-of-host-proteins-vapa-and-vapb-for-replication-via-a-phenylalanine-phenylalanine-acidic-tract-motif-mimic-in-nonstructural-viral-protein-ns1-2
#2
Broc T McCune, Wei Tang, Jia Lu, James B Eaglesham, Lucy Thorne, Anne E Mayer, Emily Condiff, Timothy J Nice, Ian Goodfellow, Andrzej M Krezel, Herbert W Virgin
The Norovirus genus contains important human pathogens, but the role of host pathways in norovirus replication is largely unknown. Murine noroviruses provide the opportunity to study norovirus replication in cell culture and in small animals. The human norovirus nonstructural protein NS1/2 interacts with the host protein VAMP-associated protein A (VAPA), but the significance of the NS1/2-VAPA interaction is unexplored. Here we report decreased murine norovirus replication in VAPA- and VAPB-deficient cells. We characterized the role of VAPA in detail...
July 11, 2017: MBio
https://www.readbyqxmd.com/read/28669671/viral-replication-complexes-are-targeted-by-lc3-guided-interferon-inducible-gtpases
#3
Scott B Biering, Jayoung Choi, Rachel A Halstrom, Hailey M Brown, Wandy L Beatty, Sanghyun Lee, Broc T McCune, Erin Dominici, Lelia E Williams, Robert C Orchard, Craig B Wilen, Masahiro Yamamoto, Jörn Coers, Gregory A Taylor, Seungmin Hwang
All viruses with positive-sense RNA genomes replicate on membranous structures in the cytoplasm called replication complexes (RCs). RCs provide an advantageous microenvironment for viral replication, but it is unknown how the host immune system counteracts these structures. Here we show that interferon-gamma (IFNG) disrupts the RC of murine norovirus (MNV) via evolutionarily conserved autophagy proteins and the induction of IFN-inducible GTPases, which are known to destroy the membrane of vacuoles containing bacteria, protists, or fungi...
July 12, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28373949/arthroscopic-reduction-of-tibial-spine-avulsion-suture-lever-reduction-technique
#4
Joseph T Gamboa, Broc A Durrant, Neil P Pathare, Edward C Shin, James L Chen
Tibial spine avulsion fractures are uncommon knee injuries that predominantly occur in children and young adults. Restoration of anterior cruciate ligament length through surgical reduction and fixation of the fracture is necessary to ensure stability of the knee with suitable range of motion and minimal knee laxity. Arthroscopic repair of tibial spine avulsion fractures is a technically complex procedure, specifically when performing and maintaining the initial anatomic reduction. We describe in this technical note and accompanying video a unique 3-point fixation repair of tibial spine avulsion fractures using an arthroscopic assisted suture lever reduction technique...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28089385/tailored-telephone-counselling-to-increase-participation-of-underusers-in-a-population-based-colorectal-cancer-screening-programme-with-faecal-occult-blood-test-a-randomized-controlled-trial
#5
B Denis, G Broc, E A Sauleau, I Gendre, K Gana, P Perrin
BACKGROUND: Despite the involvement of general practitioners, the mailing of several recall letters and of the faecal occult blood test (FOBT) kit, the uptake remains insufficient in the French colorectal cancer-screening programme. Some studies have demonstrated a greater efficacy of tailored telephone counselling over usual care, untailored invitation mailing and FOBT kit mailing. We evaluated the feasibility and the effectiveness of telephone counselling on participation in the population-based FOBT colorectal cancer-screening programme implemented in Alsace (France)...
February 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28087100/-improving-prevention-integrative-model-and-recommendations-intended-for-public-health-professionals
#6
REVIEW
G Broc, A Edjolo
Public health policies aim to diminish people's exposure to negative factors, behaviors or determinants of health. Despite awareness-raising campaigns, health recommendations are still not sufficiently followed. First, the article wondered the reasons behind this observation. In order to do this, we present a theoretical model incorporating: (a) the motivational theories of communication processing; (b) the theories of motivation and volition; (c) self-regulation and self-determination theories. In a second part, the paper describes five principles for improving communication...
January 10, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28063761/comparison-of-radiographs-and-computed-tomography-for-the-screening-of-anterior-inferior-iliac-spine-impingement
#7
COMPARATIVE STUDY
Broc R Schindler, Melanie B Venderley, Jacob D Mikula, Jorge Chahla, Grant J Dornan, Travis Lee Turnbull, Robert F LaPrade, Marc J Philippon
PURPOSE: To compare radiographic and 3-dimensional (3D) computed tomography (CT) imaging modalities for the screening of anterior inferior iliac spine (AIIS) impingement by establishing imaging measurement related to the AIIS. METHODS: Anteroposterior and false-profile radiographs and 3D CT scans were obtained on 10 human cadaveric pelvises. On the anteroposterior view for each methodology, 2 measurements were calculated: distance to the most lateral AIIS from the 12 o'clock position on the acetabular rim, and the angle between the lateral AIIS and the sagittal plane...
April 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27881671/sex-based-difference-in-achilles-peritendinous-levels-of-matrix-metalloproteinases-and-growth-factors-after-acute-resistance-exercise
#8
Broc D Astill, Mark S Katsma, David J Cauthon, Jason Greenlee, Mark Murphy, Donald Curtis, Chad C Carroll
Several recent investigations have demonstrated that the ability of various tendons to alter structural and functional properties in response to exercise are muted in women when compared to men. We hypothesize that this disparity between men and women may be due to a reduced tendon production of key mediators of tendon extracellular matrix (ECM) remodeling in response to mechanical loading, e.g. exercise. Using microdialysis before and after an acute bout of resistance exercise, we evaluated Achilles peritendinous levels of insulin-like growth factor-1 (IGF-1) and interleukin-6 (IL-6), which have both been shown to increase tendon collagen synthesis...
November 23, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27687292/decision-making-in-rectal-and-colorectal-cancer-systematic-review-and-qualitative-analysis-of-surgeons-preferences
#9
Guillaume Broc, Kamel Gana, Quentin Denost, Bruno Quintard
Surgeons are experiencing difficulties implementing recommendations not only owing to incomplete, confusing or conflicting information but also to the increasing involvement of patients in decisions relating to their health. This study sought to establish which common factors including heuristic factors guide surgeons' decision-making in colon and rectal cancers. We conducted a systematic literature review of surgeons' decision-making factors related to colon and rectal cancer treatment. Eleven of 349 identified publications were eligible for data analyses...
April 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/27668399/the-management-of-cohesion-in-written-narratives-in-students-with-specific-language-impairment-differences-between-childhood-and-adolescence
#10
Monik Favart, Anna Potocki, Lucie Broc, Pauline Quémart, Josie Bernicot, Thierry Olive
The goal of this study was to investigate the management of cohesion by children and adolescents with specific language impairment (SLI) when writing a narrative in a communicative situation. Twelve children with SLI (from 7 to 11 years old) and 12 adolescents with SLI (from 12 to 18 years old) were chronological age-matched with 24 typically developing (TD) children and 24 TD adolescents. All participants attended mainstream classes: children in elementary schools and adolescents in middle and high schools...
December 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27633329/the-geriatric-depression-scale-does-it-measure-depressive-mood-depressive-affect-or-both
#11
Kamel Gana, Nathalie Bailly, Guillaume Broc, Christophe Cazauvieilh, Nedjem Eddine Boudouda
OBJECTIVE: Self-report measures of depression are highly important tools used in research and in various healthcare settings for the diagnosis of different levels of depression. The Geriatric Depression Scale (GDS) is the first and the most popular scale used to screen for late-life depression. It is endorsed by the Royal College of Physicians and the British Geriatric Society (1992). The purpose of the present research was to investigate whether scores on the GDS15 capture depressive mood (i...
October 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27540007/discovery-of-a-proteinaceous-cellular-receptor-for-a-norovirus
#12
Robert C Orchard, Craig B Wilen, John G Doench, Megan T Baldridge, Broc T McCune, Ying-Chiang J Lee, Sanghyun Lee, Shondra M Pruett-Miller, Christopher A Nelson, Daved H Fremont, Herbert W Virgin
Noroviruses (NoVs) are a leading cause of gastroenteritis globally, yet the host factors required for NoV infection are poorly understood. We identified host molecules that are essential for murine NoV (MNoV)-induced cell death, including CD300lf as a proteinaceous receptor. We found that CD300lf is essential for MNoV binding and replication in cell lines and primary cells. Additionally, Cd300lf(-/-) mice are resistant to MNoV infection. Expression of CD300lf in human cells breaks the species barrier that would otherwise restrict MNoV replication...
August 26, 2016: Science
https://www.readbyqxmd.com/read/27537913/cyanobacterial-neurotoxin-bmaa-and-mercury-in-sharks
#13
Neil Hammerschlag, David A Davis, Kiyo Mondo, Matthew S Seely, Susan J Murch, William Broc Glover, Timothy Divoll, David C Evers, Deborah C Mash
Sharks have greater risk for bioaccumulation of marine toxins and mercury (Hg), because they are long-lived predators. Shark fins and cartilage also contain β-N-methylamino-l-alanine (BMAA), a ubiquitous cyanobacterial toxin linked to neurodegenerative diseases. Today, a significant number of shark species have found their way onto the International Union for Conservation of Nature (IUCN) Red List of Threatened Species. Many species of large sharks are threatened with extinction due in part to the growing high demand for shark fin soup and, to a lesser extent, for shark meat and cartilage products...
2016: Toxins
https://www.readbyqxmd.com/read/27537057/dyadic-cross-sectional-associations-between-negative-mood-marital-idealization-and-relationship-quality
#14
Kamel Gana, Yaël Saada, Guillaume Broc, Michèle Koleck, Christophe Cazauvieilh
This study aimed to evaluate (a) dyadic associations between relationship quality (RQ) and both depressive and anxious mood (DM and AM), (b) reciprocity hypotheses of negative mood within dyadic interactions, and (c) mediational role of marital idealization between negative mood and relationship quality. Actor-partner interdependence models (APIMs) were performed using data from a sample of 198 dyads. Our results showed that (a) these two facets of negative mood did not have the same weight on RQ and that they had a gender-specific effects pattern, and (b) there was no support for the mood transmission hypothesis...
October 2, 2016: Journal of Psychology
https://www.readbyqxmd.com/read/27529502/probing-the-biexponential-dynamics-of-ring-opening-in-7-dehydrocholesterol
#15
Broc D Smith, Kenneth G Spears, Roseanne J Sension
Our prior discovery of a novel biexponential photochemical ring-opening in 7-dehydrocholesterol (DHC) to previtamin D3 [ Tang J. Chem. Phys. 2011 , 134 , 104503 ] is further explored with ultrafast transient absorption spectroscopy, and the results are compared with recently reported high-level theoretical calculations. Three types of experiments are reported. First, variation of the excitation wavelength from 297 to 266 nm leaves the excited state dynamics unaffected. The biexponential decay of the excited state absorption is independent of excitation wavelength with time constants of 0...
August 25, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27410395/efficacy-of-a-collagen-based-dressing-in-an-animal-model-of-delayed-wound-healing
#16
COMPARATIVE STUDY
Y Guillemin, D Le Broc, C Ségalen, E Kurkdjian, J N Gouze
OBJECTIVE: The aim of this study was to evaluate in vitro and in vivo the efficacy of GBT013, a collagen-based dressing, for the treatment of chronic wounds, in a db/db mouse model of diabetes. METHOD: Macroscopic and histologic analyses of db/db mice wound healing with GBT013 or saline gauze were assessed. The mRNA expression and the proliferation of dermal fibroblast were investigated. Matrix metalloproteinases (MMP)-2 and MMP-9 activities were quantified. RESULTS: In db/db mice, GBT013 improves wound epithelialisation when compared with saline gauze...
July 2, 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27312406/interactions-between-early-life-stress-nucleus-accumbens-mecp2-expression-and-methamphetamine-self-administration-in-male-rats
#17
Candace R Lewis, Ryan M Bastle, Tawny B Manning, Sarah M Himes, Paulette Fennig, Phoebe R Conrad, Jenna Colwell, Broc A Pagni, Lyndsay A Hess, Caitlin G Matekel, Jason M Newbern, M Foster Olive
Early life stress (ELS) is highly related to the development of psychiatric illnesses in adulthood, including substance use disorders. A recent body of literature suggests that long-lasting changes in the epigenome may be a mechanism by which experiences early in life can alter neurobiological and behavioral phenotypes in adulthood. In this study, we replicate our previous findings that ELS, in the form of prolonged maternal separation, increases adult methamphetamine self-administration (SA) in male rats as compared with handled controls...
November 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27212667/subjective-wellbeing-and-longevity-findings-from-a-22-year-cohort-study
#18
Kamel Gana, Guillaume Broc, Yaël Saada, Hélène Amieva, Bruno Quintard
OBJECTIVE: The health implications of positive affect (PA) are still a matter of debate. The present study examined the longitudinal relationships between subjective wellbeing (SWB) components (i.e., Life satisfaction, PA and negative affect (NA)) and all-cause mortality in older adults. METHODS: Discrete-time survival analysis within the structural equation modeling framework was applied to data from the PAQUID Cohort (n=3777, baseline age 62-101years) including ten time periods spanning 22years...
June 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27175620/a-modern-multidisciplinary-approach-to-patients-suffering-from-cervical-spondylotic-myelopathy
#19
Enrico Tessitore, Nicolas Broc, Abdelhafid Mekideche, Margitta Seeck, André Truffert, Maria I Vargas, Claudio Schonauer, Karl Schaller
BACKGROUND: The traditional approach to patients suffering from cervical spondylotic myelopathy (CSM) consists of mere assessment of radiological standard MR images and evaluation of surgical indication, depending on clinical symptoms and degree of radiological stenosis. Identification of prognostic factors for surgery remains difficult. Surgery is thought to be able to stop the disease progression, while significant improvements of neurological symptoms are not predictable. METHODS: Authors present a modern approach to patients with CSM, that is comprehensive of clinical, electrophysiological and radiological findings, and that has been developed by a multidisciplinary team of experts (neurosurgeons, neurologists, neuroradiologists)...
May 13, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27156252/traumatic-brain-injury-with-a-machete-penetrating-the-dura-and-brain-case-report-from-southeast-mexico
#20
Juan D Del Castillo-Calcáneo, Ulises Bravo-Angel, Raúl Mendez-Olan, Francisco Rodriguez-Valencia, Javier Valdés-García, Ulises García-González, Guy G Broc-Haro
INTRODUCTION: Traumatic Brain Injury (TBI) is a major cause of death and disability in our society, we present the first case report of non-missile penetrating (NMP) cranial trauma with a machete in Mexico, and our objective by presenting this case is to prove the usefulness of recently proposed algorithms in the treatment of NMP PRESENTATION OF CASE: We present the case of a 47 year old woman who received a machete hit to the right side of her head during an assault., she arrived fully conscious to the emergency department (ED), computed tomography was performed and based on the findings of this study and in accordance to recently proposed algorithms for managing NMP cranial trauma a craniotomy was performed, at follow-up the patient presented wtih minor neurological disability in the form of left hemiparesis...
2016: International Journal of Surgery Case Reports
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