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Broc D Astill, Mark S Katsma, David J Cauthon, Jason Greenlee, Mark Murphy, Donald Curtis, Chad C Carroll
Several recent investigations have demonstrated that the ability of various tendons to alter structural and functional properties in response to exercise are muted in women when compared to men. We hypothesize that this disparity between men and women may be due to a reduced tendon production of key mediators of tendon extracellular matrix (ECM) remodeling in response to mechanical loading, e.g. exercise. Using microdialysis before and after an acute bout of resistance exercise, we evaluated Achilles peritendinous levels of insulin-like growth factor-1 (IGF-1) and interleukin-6 (IL-6), which have both been shown to increase tendon collagen synthesis...
November 23, 2016: Journal of Applied Physiology
Guillaume Broc, Kamel Gana, Quentin Denost, Bruno Quintard
Surgeons are experiencing difficulties implementing recommendations not only owing to incomplete, confusing or conflicting information but also to the increasing involvement of patients in decisions relating to their health. This study sought to establish which common factors including heuristic factors guide surgeons' decision-making in colon and rectal cancers. We conducted a systematic literature review of surgeons' decision-making factors related to colon and rectal cancer treatment. Eleven of 349 identified publications were eligible for data analyses...
August 16, 2016: Psychology, Health & Medicine
Monik Favart, Anna Potocki, Lucie Broc, Pauline Quémart, Josie Bernicot, Thierry Olive
The goal of this study was to investigate the management of cohesion by children and adolescents with specific language impairment (SLI) when writing a narrative in a communicative situation. Twelve children with SLI (from 7 to 11 years old) and 12 adolescents with SLI (from 12 to 18 years old) were chronological age-matched with 24 typically developing (TD) children and 24 TD adolescents. All participants attended mainstream classes: children in elementary schools and adolescents in middle and high schools...
September 23, 2016: Research in Developmental Disabilities
Kamel Gana, Nathalie Bailly, Guillaume Broc, Christophe Cazauvieilh, Nedjem Eddine Boudouda
OBJECTIVE: Self-report measures of depression are highly important tools used in research and in various healthcare settings for the diagnosis of different levels of depression. The Geriatric Depression Scale (GDS) is the first and the most popular scale used to screen for late-life depression. It is endorsed by the Royal College of Physicians and the British Geriatric Society (1992). The purpose of the present research was to investigate whether scores on the GDS15 capture depressive mood (i...
September 15, 2016: International Journal of Geriatric Psychiatry
Robert C Orchard, Craig B Wilen, John G Doench, Megan T Baldridge, Broc T McCune, Ying-Chiang J Lee, Sanghyun Lee, Shondra M Pruett-Miller, Christopher A Nelson, Daved H Fremont, Herbert W Virgin
Noroviruses (NoVs) are a leading cause of gastroenteritis globally, yet the host factors required for NoV infection are poorly understood. We identified host molecules that are essential for murine NoV (MNoV)-induced cell death, including CD300lf as a proteinaceous receptor. We found that CD300lf is essential for MNoV binding and replication in cell lines and primary cells. Additionally, Cd300lf(-/-) mice are resistant to MNoV infection. Expression of CD300lf in human cells breaks the species barrier that would otherwise restrict MNoV replication...
August 26, 2016: Science
Neil Hammerschlag, David A Davis, Kiyo Mondo, Matthew S Seely, Susan J Murch, William Broc Glover, Timothy Divoll, David C Evers, Deborah C Mash
Sharks have greater risk for bioaccumulation of marine toxins and mercury (Hg), because they are long-lived predators. Shark fins and cartilage also contain β-N-methylamino-l-alanine (BMAA), a ubiquitous cyanobacterial toxin linked to neurodegenerative diseases. Today, a significant number of shark species have found their way onto the International Union for Conservation of Nature (IUCN) Red List of Threatened Species. Many species of large sharks are threatened with extinction due in part to the growing high demand for shark fin soup and, to a lesser extent, for shark meat and cartilage products...
2016: Toxins
Kamel Gana, Yaël Saada, Guillaume Broc, Michèle Koleck, Christophe Cazauvieilh
This study aimed to evaluate (a) dyadic associations between relationship quality (RQ) and both depressive and anxious mood (DM and AM), (b) reciprocity hypotheses of negative mood within dyadic interactions, and (c) mediational role of marital idealization between negative mood and relationship quality. Actor-partner interdependence models (APIMs) were performed using data from a sample of 198 dyads. Our results showed that (a) these two facets of negative mood did not have the same weight on RQ and that they had a gender-specific effects pattern, and (b) there was no support for the mood transmission hypothesis...
October 2, 2016: Journal of Psychology
Broc D Smith, Kenneth G Spears, Roseanne J Sension
Our prior discovery of a novel biexponential photochemical ring-opening in 7-dehydrocholesterol (DHC) to previtamin D3 [ Tang J. Chem. Phys. 2011 , 134 , 104503 ] is further explored with ultrafast transient absorption spectroscopy, and the results are compared with recently reported high-level theoretical calculations. Three types of experiments are reported. First, variation of the excitation wavelength from 297 to 266 nm leaves the excited state dynamics unaffected. The biexponential decay of the excited state absorption is independent of excitation wavelength with time constants of 0...
August 25, 2016: Journal of Physical Chemistry. A
Y Guillemin, D Le Broc, C Ségalen, E Kurkdjian, J N Gouze
OBJECTIVE: The aim of this study was to evaluate in vitro and in vivo the efficacy of GBT013, a collagen-based dressing, for the treatment of chronic wounds, in a db/db mouse model of diabetes. METHOD: Macroscopic and histologic analyses of db/db mice wound healing with GBT013 or saline gauze were assessed. The mRNA expression and the proliferation of dermal fibroblast were investigated. Matrix metalloproteinases (MMP)-2 and MMP-9 activities were quantified. RESULTS: In db/db mice, GBT013 improves wound epithelialisation when compared with saline gauze...
July 2, 2016: Journal of Wound Care
Candace R Lewis, Ryan M Bastle, Tawny B Manning, Sarah M Himes, Paulette Fennig, Phoebe R Conrad, Jenna Colwell, Broc A Pagni, Lyndsay A Hess, Caitlin G Matekel, Jason M Newbern, M Foster Olive
Early life stress (ELS) is highly related to the development of psychiatric illnesses in adulthood, including substance use disorders. A recent body of literature suggests that long-lasting changes in the epigenome may be a mechanism by which experiences early in life can alter neurobiological and behavioral phenotypes in adulthood. In this study, we replicate our previous findings that ELS, in the form of prolonged maternal separation, increases adult methamphetamine self-administration (SA) in male rats as compared with handled controls...
November 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Kamel Gana, Guillaume Broc, Yaël Saada, Hélène Amieva, Bruno Quintard
OBJECTIVE: The health implications of positive affect (PA) are still a matter of debate. The present study examined the longitudinal relationships between subjective wellbeing (SWB) components (i.e., Life satisfaction, PA and negative affect (NA)) and all-cause mortality in older adults. METHODS: Discrete-time survival analysis within the structural equation modeling framework was applied to data from the PAQUID Cohort (n=3777, baseline age 62-101years) including ten time periods spanning 22years...
June 2016: Journal of Psychosomatic Research
Enrico Tessitore, Nicolas Broc, Abdelhafid Mekideche, Margitta Seeck, André Truffert, Maria I Vargas, Claudio Schonauer, Karl Schaller
BACKGROUND: The traditional approach to patients suffering from cervical spondylotic myelopathy (CSM) consists of mere assessment of radiological standard MR images and evaluation of surgical indication, depending on clinical symptoms and degree of radiological stenosis. Identification of prognostic factors for surgery remains difficult. Surgery is thought to be able to stop the disease progression, while significant improvements of neurological symptoms are not predictable. METHODS: Authors present a modern approach to patients with CSM, that is comprehensive of clinical, electrophysiological and radiological findings, and that has been developed by a multidisciplinary team of experts (neurosurgeons, neurologists, neuroradiologists)...
May 13, 2016: Journal of Neurosurgical Sciences
Juan D Del Castillo-Calcáneo, Ulises Bravo-Angel, Raúl Mendez-Olan, Francisco Rodriguez-Valencia, Javier Valdés-García, Ulises García-González, Guy G Broc-Haro
INTRODUCTION: Traumatic Brain Injury (TBI) is a major cause of death and disability in our society, we present the first case report of non-missile penetrating (NMP) cranial trauma with a machete in Mexico, and our objective by presenting this case is to prove the usefulness of recently proposed algorithms in the treatment of NMP PRESENTATION OF CASE: We present the case of a 47 year old woman who received a machete hit to the right side of her head during an assault., she arrived fully conscious to the emergency department (ED), computed tomography was performed and based on the findings of this study and in accordance to recently proposed algorithms for managing NMP cranial trauma a craniotomy was performed, at follow-up the patient presented wtih minor neurological disability in the form of left hemiparesis...
2016: International Journal of Surgery Case Reports
Aspassia D Chatziefthimiou, James S Metcalf, W Broc Glover, Sandra A Banack, Soha R Dargham, Renee A Richer
Desert environments and drylands experience a drastic scarcity of water resources. To alleviate dependence on freshwater for drinking water needs, countries have invested in infrastructure development of desalination plants. Collectively, the countries of the Arabian Gulf produce 45% of the world's desalinated water, which is stored in dams, mega-reservoirs and secondary house water tanks to secure drinking water beyond daily needs. Improper storage practices of drinking water in impoundments concomitant with increased temperatures and light penetration may promote the growth of cyanobacteria and accumulation of cyanotoxins...
May 2016: Toxicon: Official Journal of the International Society on Toxinology
Kamel Gana, Yaël Saada, Guillaume Broc, Bruno Quintard, Hélène Amieva, Jean-François Dartigues
OBJECTIVE: Reciprocal relationships between positive affect (PA) and health are now subject of a heuristic debate in psychology and behavioral medicine. Two radically opposed approaches address the link between subjective well being (SWB) and physical health: top-down (i.e., psychosomatic hypothesis) and bottom-up (i.e., disability/ability hypothesis) approaches. The aim of the present study was to test these two approaches by investigating thirteen-year longitudinal relationships between PA, as an affective dimension of SWB, and functional health in older people...
February 2016: Social Science & Medicine
Aya Abou Hammoud, Nina Kirstein, Virginie Mournetas, Anais Darracq, Sabine Broc, Camille Blanchard, Dana Zeineddine, Mohamad Mortada, Helene Boeuf
Mouse embryonic stem cells (mESCs) are expanded and maintained pluripotent in vitro in the presence of leukemia inhibitory factor (LIF), an IL6 cytokine family member which displays pleiotropic functions, depending on both cell maturity and cell type. LIF withdrawal leads to heterogeneous differentiation of mESCs with a proportion of the differentiated cells apoptosising. During LIF withdrawal, cells sequentially enter a reversible and irreversible phase of differentiation during which LIF addition induces different effects...
2016: PloS One
W Broc Glover, Teesha C Baker, Susan J Murch, Paula N Brown
A single-laboratory validation study was completed for the determination of β-N-methylamino-L-alanine (BMAA), N-(2-aminoethyl)glycine (AEG), and 2,4-diaminobutyric acid (DAB) in bulk natural health product supplements purchased from a health food store in Canada. BMAA and its isomers were extracted with acid hydrolysis to free analytes from protein association. Acid was removed with the residue evaporated to dryness and reconstituted with derivatization using 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AccQ-Fluor)...
November 2015: Journal of AOAC International
W Andrew Lee, Adriana J Saroki, Sverre Løken, Christiano A C Trindade, Tyler R Cram, Broc R Schindler, Robert F LaPrade, Marc J Philippon
BACKGROUND: Anatomic landmarks located on the proximal femur have only recently been defined, and there is a lack of radiographic guidelines for their locations presented in the literature. With the confident identification of these landmarks, radiographs could provide more assistance in preoperative evaluations, intraoperative guidance, and postoperative assessments. PURPOSE: To quantify the radiographic locations of endoscopic landmarks of the proximal femur. STUDY DESIGN: Descriptive laboratory study...
January 2016: American Journal of Sports Medicine
W Andrew Lee, Adriana J Saroki, Sverre Løken, Christiano A C Trindade, Tyler R Cram, Broc R Schindler, Robert F LaPrade, Marc J Philippon
BACKGROUND: The anatomy of the acetabulum has been described extensively in the literature, but radiographic acetabular guidelines have not been well established. This study provides a radiographic map of acetabular landmarks in the hip. PURPOSE/HYPOTHESIS: The purpose of this study was to quantify the precise radiographic location of arthroscopic landmarks around the acetabulum. The hypothesis was that their locations were reproducible despite variability in the anatomy and positioning of pelvic specimens...
January 2016: American Journal of Sports Medicine
Raghuveer Singh, Amrita Banerjee, Susheel Kumar Sharma, R Bhagawati, Sikimoni Baruah, S V Ngachan
The occurrence of Turnip mosaic virus (TuMV) in cole crops (Brassica spp) grown in Basar, Arunachal Pradesh, India was confirmed by symptomatology, transmission electron microscopy, reverse transcription-polymerase chain reaction and partial characterization of cytoplasmic inclusion protein and coat protein (CP) domains. Phylogenetic analysis of the partial CP sequences of the new TuMV isolates from Indian mustard (AR-IndM), broad leaved mustard (AR-BrLM) and broccoli (AR-Broc) revealed their closest relationship with members of the World-B genogroup of TuMV...
September 2015: Virusdisease
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