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https://www.readbyqxmd.com/read/29933047/pharmacologic-inhibition-of-akt-leads-to-cell-death-in-relapsed-multiple-myeloma
#1
In-Sung Song, Yu Jeong Jeong, Seung Hun Jeong, Hyoung Kyu Kim, Nam-Chul Ha, MyungGeun Shin, Kyung Soo Ko, Byoung Doo Rhee, Sungbo Shim, Sung-Wuk Jang, Jin Han
Multiple myeloma (MM) is a neoplastic plasma cell disorder with high disease recurrence rates. Novel therapeutic approaches capable of improving outcomes in patients with MM are urgently required. The AKT signalling plays a critical regulatory role in MM pathophysiology, including survival, proliferation, metabolism, and has emerged as a key therapeutic target. Here, we identified a novel AKT inhibitor, HS1793, and defined its mechanism of action and clinical significance in MM. HS1793 disrupted the interaction between AKT and heat shock protein 90, resulting in protein phosphatase 2A-modulated phosphorylated-AKT (p-AKT) reduction...
June 19, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29930154/caserta-e-chea-j-minnix-m-et-al-copper-64-labeled-daratumumab-as-a-pet-ct-imaging-tracer-for-multiple-myeloma-blood-2018-131-7-741-745
#2
(no author information available yet)
No abstract text is available yet for this article.
June 21, 2018: Blood
https://www.readbyqxmd.com/read/29875288/false-positive-findings-on-6-18f-fluor-l-3-4-dihydroxyphenylalanine-positron-emission-tomography-18f-fdopa-pet-performed-for-imaging-of-neuroendocrine-tumors
#3
Annika M A Berends, Michiel N Kerstens, Janne W Bolt, Thera P Links, Esther Korpershoek, Ronald R de Krijger, Annemiek M E Walenkamp, Walter Noordzij, Boudewijn van Etten, Gursah Kats-Ugurlu, Ah Brouwers, A N A van der Horst-Schrivers
BACKGROUND/AIM: Positron Emission Tomography (PET) with 6-[18F]fluor-L-3,4-dihydroxyphenylalanine (18F-FDOPA) has been shown to be a useful imaging tool with a high sensitivity for the visualization of neuroendocrine tumors (NETs). 18F-FDOPA uptake in tumors other than NETs has been suggested previously, but data on this phenomenon are limited. We therefore studied the non-physiological, false-positive uptake of 18F-FDOPA in a large population of patients with a NET or with a high clinical suspicion of harboring a NET...
June 6, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29866662/testicular-plasmacytoma-misdiagnosed-as-orchitis
#4
Christopher Schiavo, Steven Alexander Mann, Jesse Mer, Attaya Suvannasankha
Testicular plasmacytomas are rare, accounting for only 1.3% of all extramedullary plasmacytomas. The infrequency in which it is encountered, coupled with its non-specific clinical and sonographic presentation, makes its diagnosis a challenge. We present a case of a 70-year-old man with multiple myeloma, which was systemically responding to chemotherapy, who developed testicular swelling, erythema and pain. Ultrasound findings were concerning for infection, although urine and serum testing were unremarkable...
June 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29813003/preparation-and-application-of-a-monoclonal-antibody-against-chicken-trim62
#5
Xiaoman Wang, Yongzhen Zhao, Ling Li, Ziqiang Cheng, Guihua Wang
TRIM62 is a member of the tripartite interaction motif (TRIM) family and exerts crucial roles in innate immune response and cancer. To investigate the relationship between its distribution and avian retrovirus replication, in the present study, a monoclonal antibody (mAb) against chicken TRIM62 was generated. The open reading frame of chicken TRIM62 was amplified by polymerase chain reaction (PCR) and inserted into the expression vector pET-28a. The recombinant expression vectors were transformed into Escherichia coli BL21 (DE3)...
May 29, 2018: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29806594/correlation-between-baseline-18f-fdg-pet-ct-findings-and-cd38-cd138-expressing-myeloma-cells-in-bone-marrow-and-clinical-parameters-in-patiens-with-multiple-myeloma
#6
Arzu Cengiz, Hayri Üstün Arda, Firuzan Döğer, İrfan Yavaşoğlu, Yakup Yürekli, Ali Zahit Bolaman
OBJECTIVE: The aim of this study was to evaluate the association between the degree of F-18 FDG uptake and CD38, CD138 expression in myeloma cells in bone marrow and other clinical parameters in patients with multiple myeloma (MM). MATERIALS AND METHODS: Patients with the diagnosis MM who underwent 18F-FDG PET/CT for initial staging were evaluated retrospectively. We analyzed a total of 42 patients (43-83 years-old, mean:64.4 ±9.9). Hematological and biochemical tests including hemoglobin (Hb), hematocrit (Htc), C-reactive protein (CRP), beta2-microglobulin (β2M), creatinine (Cr), albumin, calcium (Ca), lactate dehydrogenase (LDH), erythrocyte sedimentation rate were recorded...
May 28, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29805699/a-predicting-model-of-bone-marrow-malignant-infiltration-in-18-f-fdg-pet-ct-images-with-increased-diffuse-bone-marrow-fdg-uptake
#7
Mingge Zhou, Yumei Chen, Jianjun Liu, Gang Huang
Purpose: To demonstrate the relationship between the etiologies of increased diffuse bone marrow (BM) 18 F-FDG uptake and PET/CT imaging/clinical features, as well as to explore a predicting model of BM malignant infiltration (MI) based on decision tree. Methods: 84 patients with increased diffuse BM uptake were retrospectively enrolled. Their complete case record and PET/CT images were reviewed, with the maximal standardized uptake values of bone marrow (SUVmaxBM) and other imaging/clinical features were noted...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29759149/functional-imaging-methods-for-assessment-of-minimal-residual-disease-in-multiple-myeloma-current-status-and-novel-immunopet-based-methods
#8
REVIEW
Neeta Pandit-Taskar
Imaging plays a key role in assessment of myeloma. Osteolytic bone lesions are optimally assessed using structural imaging, however the structural changes lag the functional changes in the disease. Functional imaging with fluoro deoxy glucose (FDG) positron emission tomography (PET) computerized tomography (CT) is useful in assessment of high-risk myeloma. FDG PET provides prognostic information and is helpful in monitoring response to therapy. However, it is nonspecific and may not be optimal in assessing treatment response to immunotherapeutic agents...
January 2018: Seminars in Hematology
https://www.readbyqxmd.com/read/29746513/role-of-18f-fdg-pet-ct-in-patients-without-known-primary-malignancy-with-skeletal-lesions-suspicious-for-cancer-metastasis
#9
Soo Bin Park, Jung Mi Park, Seung Hwan Moon, Young Seok Cho, Jong-Mu Sun, Byung-Tae Kim, Kyung-Han Lee
BACKGROUND: When subjects without a known malignancy present with suspicious skeletal lesions, differential diagnosis and primary cancer identification is important. Here, we investigated the role of FDG PET/CT in this clinical situation. METHODS: We enrolled 103 patients with no known malignancies who were referred for FDG PET/CT because of bone lesions that were suspicious for cancer metastasis. Each extra-skeletal FDG lesion was categorized as consistent with primary cancer or with metastasis based on the distribution and pattern of all abnormal lesions in the individual...
2018: PloS One
https://www.readbyqxmd.com/read/29717914/added-prognostic-value-of-fdg-pet-ct-in-relapsing-multiple-myeloma-patients
#10
Bastien Jamet, Clément Bailly, Thomas Carlier, Lucie Planche, Cyrille Touzeau, Françoise Kraeber-Bodéré, Philippe Moreau, Caroline Bodet-Milin
No abstract text is available yet for this article.
May 2, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29713226/prognostic-value-of-baseline-18-f-fluorodeoxyglucose-pet-ct-in-patients-with-multiple-myeloma-a-multicenter-cohort-study
#11
Seung Hwan Moon, Woo Hee Choi, Ie Ryung Yoo, Soo Jin Lee, Jin Chul Paeng, Shin Young Jeong, Sang-Woo Lee, Kihyun Kim, Joon Young Choi
Objective: We investigated the prognostic value of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) in patients with multiple myeloma (MM). Materials and Methods: Subjects were 76 patients with newly diagnosed myeloma and pretreatment with 18 F-FDG PET/CT from four hospitals. The PET/CT features were evaluated and the clinical characteristics were reviewed. Prognostic factors related to poor progression-free survival (PFS) and overall survival (OS) were identified using a Cox proportional hazards regression model and a prediction scale was developed based on the identified factors...
May 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29701372/unusual-behavior-of-a-lung-inflammatory-myofibroblastic-tumor-case-report
#12
Cristina Rodrigues, Daniel Cabral, Teresa Almodovar, Analisa Ribeiro, Diogo Delgado, Leonor Mota, Samuel Mendes, Magda Alvoeiro, Carolina Torres, Telma Calado, Mariana Antunes, Francisco Félix
INTRODUCTION: 55 years old, male patient. History of heavy smoking (65 UMA) and COPD. Admitted to hospital due to a left pneumonia. Thoracic CT and PET-Scan, showed left lower lobe mass measuring 92x89 mm (SUVmax 49). Several mediastinal node groups presented increased uptake of FDG. A fiberoptic bronchoscopy was performed. Citology of the bronchoalveolar lavage suggested a squamous carcinoma. EBUS of node stations 4R, 4L e 7 without evidence of malignancy. METHODS: The case was taken to a multidisciplinary meeting staged as IIIA (T3N2M0)...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701218/synthesis-of-c-functionalized-te1pa-and-comparison-with-its-analogues-an-example-of-bioconjugation-on-9e7-4-mab-for-multiple-myeloma-64-cu-pet-imaging
#13
Thomas Le Bihan, Anne-Sophie Navarro, Nathalie Le Bris, Patricia Le Saëc, Sébastien Gouard, Ferid Haddad, Jean-François Gestin, Michel Chérel, Alain Faivre-Chauvet, Raphaël Tripier
In view of the excellent copper(ii) and 64-copper(ii) complexation of a TE1PA ligand, a monopicolinate cyclam, in both aqueous medium and in vivo, we looked for a way to make it bifunctional, while maintaining its chelating properties. Overcoming the already known drawback of grafting via its carboxyl group, which is essential to the overall properties of the ligand, a TE1PA bifunctional derivative bearing an additional isothiocyanate coupling function on a carbon atom of the macrocyclic ring was synthesized...
June 13, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29700126/imaging-melphalan-therapy-response-in-preclinical-extramedullary-myeloma-with-18-f-fdopa-and-18-f-fdg-pet
#14
Deep Hathi, Elizabeth DeLassus, Samuel Achilefu, Jonathan McConathy, Monica Shokeen
Multiple myeloma (MM) is a debilitating neoplasm of terminally differentiated plasma B-cells that has resulted in over 13,000 deaths in 2017 alone. Combination therapies involving melphalan, a small molecule DNA alkylating agent, are commonly prescribed to patients with relapsed/refractory MM, which necessitates the stratification of responding patients to minimize toxicities and improve quality of life. Here, we evaluated the use of 18 F-FDOPA, a clinically available positron emission tomography (PET) radiotracer with specificity to the L-type amino acid transporter-1 (LAT1), which also mediates melphalan uptake, for imaging melphalan therapy response in a preclinical immunocompetent model of MM...
April 26, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29685954/clinical-characteristics-and-prognosis-of-multiple-myeloma-with-bone-related-extramedullary-disease-at-diagnosis
#15
Chen Tian, Lu Wang, Ling Wu, Lei Zhu, Wengui Xu, Zhaoxiang Ye, Zhigang Zhao, Yafei Wang, Yizhuo Zhang
Multiple myeloma (MM) is a hematological neoplasm which results in diffuse or focal bone infiltration and extramedullary lesions. It's reported that infiltration of organs by plasma cells indicated worse prognosis, but the prognosis of patients with bone-related extramedullary disease (bEMD) is still unknown. One hundred and fourteen newly diagnosed MM patients were retrospectively reviewed. Results showed that the clinical features, overall survival (OS), and progression-free survival (PFS) of patients with and without bEMD had no statistical significance...
June 29, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29671193/diagnostic-performance-of-18-f-fdg-pet-ct-and-whole-body-mri-before-and-early-after-treatment-of-multiple-myeloma-a-prospective-comparative-study
#16
Mohammad Abd Alkhalik Basha, Maged Abdel Gelil Hamed, Rania Refaat, Mohamad Zakarya AlAzzazy, Manar A Bessar, Elshaimaa Mohamed Mohamed, Ayman F Ahmed, Heba Fathy Tantawy, Khaled Mohamed Altaher, Ahmed Ali Obaya, Amira Hamed Mohamed Afifi
OBJECTIVE: To determine the diagnostic accuracy of WB-MRI and 18 F-FDG PET/CT in detecting infiltration pattern, disease activity, and response to treatment in patients with multiple myeloma (MM). MATERIALS AND METHODS: Fifty-six patients with confirmed MM were included in the present study for pre-treatment evaluation. Among these individuals, 22 patients were available for the post-treatment evaluation of response to therapy. All patients were imaged with both WB-MRI and 18 F-FDG PET/CT...
June 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29667156/how-we-manage-patients-with-plasmacytomas
#17
REVIEW
Despina Fotiou, Meletios A Dimopoulos, Efstathios Kastritis
PURPOSE OF REVIEW: To discuss the diagnostic approach, treatment options, and future considerations in the management of plasmacytomas, either solitary or in the context of overt multiple myeloma (MM). RECENT FINDINGS: Advanced imaging techniques such as whole-body magnetic resonance imaging and positron emission tomography/computerized tomography are essential for the diagnostic workup of solitary plasmacytomas (SP) to rule out the presence of other disease foci...
April 17, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29620592/fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-amyloid-arthropathy-associated-to-multiple-myeloma
#18
Aida Sabaté-Llobera, Elena Llinares, Rolando Vallansot, Julieta Landeyro, Cristina Gámez-Cenzano
No abstract text is available yet for this article.
March 19, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29610955/prognostic-value-of-18-f-fdg-pet-ct-in-multiple-myeloma-patients-before-and-after-allogeneic-hematopoietic-cell-transplantation
#19
Antje Stolzenburg, Katharina Lückerath, Samuel Samnick, Martin Speer, Katharina Kneer, Jan-Stefan Schmid, Götz Ulrich Grigoleit, Susanne Hofmann, Ambros J Beer, Donald Bunjes, Stefan Knop, Andreas K Buck, Hermann Einsele, Constantin Lapa
PURPOSE: Despite improved treatment options, multiple myeloma (MM) remains an incurable disease. The aim of this study was to investigate the prognostic value of positron emission tomography/computed tomography (PET/CT) using 18 F-2'-deoxy-2'-fluorodeoxyglucose ([18 F]FDG) in MM patients shortly before and ~100 days after allogeneic hematopoietic cell transplantation (allo-HCT). METHODS: In this retrospective analysis, we evaluated [18 F]FDG-PET/CT-scans of 45 heavily pre-treated MM patients before and 27 patients after scheduled allo-HCT...
April 2, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29597141/preliminary-evaluation-of-18-f-labeled-llp2a-trifluoroborate-conjugates-as-vla-4-%C3%AE-4-%C3%AE-1-integrin-specific-radiotracers-for-pet-imaging-of-melanoma
#20
Áron Roxin, Chengcheng Zhang, Sungjoon Huh, Mathieu L Lepage, Zhengxing Zhang, Kuo-Shyan Lin, François Bénard, David M Perrin
INTRODUCTION: The transmembrane α4 β1 integrin receptor, or very-late antigen 4 (VLA-4), is associated with tumor metastasis and angiogenesis, the development of chemotherapeutic drug resistance, and is overexpressed in multiple myelomas, osteosarcomas, lymphomas, leukemias, and melanomas. The peptidomimetic, LLP2A, is a high-affinity ligand with specificity for the extracellular portion of VLA-4 and several conjugates have been evaluated in vivo by NIR-fluorescence, 111 In-SPECT and 68 Ga- and 64 Cu-PET imaging, but to date, not with 18 F-PET...
March 12, 2018: Nuclear Medicine and Biology
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