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https://www.readbyqxmd.com/read/28343327/osteolytic-variant-poems-syndrome-an-uncommon-presentation-of-osteosclerotic-myeloma
#1
Michael S Clark, Benjamin M Howe, Katrina N Glazebrook, Michelle L Mauermann, Stephen M Broski
Polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome, a form of osteosclerotic myeloma, is a multisystem disease related to a monoclonal plasma cell proliferative disorder. Osseous lesions are most commonly sclerotic on radiographs and computed tomography (CT), demonstrate low T1 and T2 signal intensity on magnetic resonance imaging (MRI), and have variable degrees of avidity on positon emission tomography (PET) imaging using 18-fluorodeoxyglucose ((18)F-FDG). We present three cases of POEMS syndrome manifesting as osteolytic lesions with indolent features, including well-defined thin sclerotic rims, no cortical disruption or periosteal reaction, no associated soft-tissue mass, and a periarticular location, all features that could lead to misinterpretation as benign bone lesions...
March 25, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28317080/the-critical-role-of-imaging-in-the-management-of-multiple-myeloma
#2
REVIEW
Shahzad Raza, Siyang Leng, Suzanne Lentzsch
Multiple myeloma (MM) is characterized by abnormal proliferation of plasma cells in the bone marrow leading to symptoms of anemia, renal failure, hypercalcemia, and bone lesions. Bone imaging is critical for the diagnosis, staging, assessment for the presence and extent of bone lesions, and initial treatment of MM. Skeletal survey is the preferred initial imaging modality due to its availability and low cost. However, it has poor sensitivity and patients with occult myeloma may escape detection, delaying their diagnosis and treatment...
March 20, 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/28264597/report-of-the-6th-international-workshop-on-pet-in-lymphoma
#3
Cristina Nanni, Anne Ségolène Cottereau, Egesta Lopci, Caroline Bodet-Milin, Monica Coronado, Barbara Pro, Wong Seog Kim, Judith Trotman, Sally Barrington, Ulrich Duhrsen, Thierry Vander Borght, Elena Zamagni, Françoise Kraeber-Bodéré, Christina Messiou, Alain Rahmouni, Irène Buvat, Marc Andre, Mark Hertzberg, Wim Oyen, Olivier Casasnovas, Stefano Luminari, Laurent Garderet, Françoise Montravers, Carsten Kobe, Regine Kluge, Annibale Versari, Emanuele Zucca, Philippe Moreau, Bruce Cheson, Corinne Haioun, Andrea Gallamini, Michel Meignan
Two hundred and ten nuclear medicine physicians, radiologists, and hematologists from 26 countries attended the 6th International Workshop on Positron Emission Tomography (PET) in Lymphoma and Myeloma held in Menton, France, in September 2016. The meeting was under the auspices of the European Lymphoma Institute (ELI), the European Association of Nuclear Medicine (EANM) the Lymphoma Study Association (LYSA), the Italian Foundation on Lymphoma (FIL) and the Carnot Institute for Lymphoma (CALYM). Forty scientific posters were presented...
March 7, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28240368/extensive-remineralization-of-large-pelvic-lytic-lesions-following-total-therapy-treatment-in-patients-with-multiple-myeloma
#4
Meera Mohan, Rohan S Samant, Donghoon Yoon, Amy F Buros, Antonio Branca, Corey O Montgomery, Richard Nicholas, Larry J Suva, Roy Morello, Sharmilan Thanendrarajan, Carolina Schinke, Shmuel Yaccoby, Frits van Rhee, Faith E Davies, Gareth J Morgan, Maurizio Zangari
Osteolytic bone lesions are a hallmark of multiple myeloma bone disease. Bone destruction is associated with severely imbalanced bone remodeling, secondary to increased osteoclastogenesis and significant osteoblast suppression. Lytic lesions of the pelvis are relatively common in MM patients and are known to contribute to the increased morbidity due to the high risk of fracture that frequently demands extensive surgical intervention.After observing unexpected radiological improvement in serial large pelvic CT assessment in a patient treated in a total therapy protocol, the radiographic changes of pelvic osteolytic lesions by CT/PET scanning in patients who received total therapy 4 treatment for myeloma were retrospectively analyzed...
February 27, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28218709/pet-imaging-for-initial-staging-and-therapy-assessment-in-multiple-myeloma-patients
#5
REVIEW
Clément Bailly, Rodolphe Leforestier, Bastien Jamet, Thomas Carlier, Mickael Bourgeois, François Guérard, Cyrille Touzeau, Philippe Moreau, Michel Chérel, Françoise Kraeber-Bodéré, Caroline Bodet-Milin
Multiple myeloma (MM) is a hematological neoplasm characterized by the clonal proliferation of malignant plasma cells in the bone marrow. MM results in diffuse or focal bone infiltration and extramedullary lesions. Over the past two decades, advances have been made with regard to the diagnosis, staging, treatment, and imaging of MM. Computed tomography (CT) and magnetic resonance imaging (MRI) are currently recommended as the most effective imaging modalities at diagnostic. Yet, recent data from the literature suggest that positron emission tomography combined with computed tomography (PET/CT) using (18)F-deoxyglucose (FDG) is a promising technique for initial staging and therapeutic monitoring in this pathology...
February 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28195903/muscle-involvement-of-multiple-myeloma-revealed-by-fdg-pet-ct
#6
Meng Liang, Minggang Su, Rang Wang, Weiya Wang, Chengzhong Fan
Extramedullary myeloma can occur in variety of organs; however, muscle involvement is rarely reported. Here we present a case of a multiple myeloma patient with muscle involvement found by F-FDG PET/CT, which is sensitive in detecting extramedullary lesions of multiple myeloma. Plasmacytoma was confirmed by pathological biopsy afterwards.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28072730/bortezomib-combined-with-lenalidomide-as-the-first-line-treatment-for-the-rare-synchronous-occurrence-of-multiple-myeloma-and-pulmonary-adenocarcinoma-a-case-report
#7
Wenli Zuo, Xinghu Zhu, Jingke Yang, Zhenyang Mei, Mei Deng, Quande Lin, Yongping Song, Qingsong Yin
BACKGROUND: Simultaneous multiple myeloma (MM) and pulmonary adenocarcinoma is a rare occurrence, and thus, treatment is a challenge. This study reports on 1 such case of MM with concurrent lung cancer, where an accurate diagnosis was made and the patient underwent treatment for both cancers. CASE SUMMARY: A 68-year-old man presented with 2 months of progressive lower back pain. Visualization with magnetic resonance imaging (MRI) revealed multiple collapsed vertebrae from T12 to S3, as well as an altered signal intensity at the T3 vertebra...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28042328/-68-ga-pentixafor-pet-ct-for-imaging-of-chemokine-receptor-cxcr4-expression-in-multiple-myeloma-comparison-to-18-f-fdg-and-laboratory-values
#8
Constantin Lapa, Martin Schreder, Andreas Schirbel, Samuel Samnick, Klaus Martin Kortüm, Ken Herrmann, Saskia Kropf, Herrmann Einsele, Andreas K Buck, Hans-Jürgen Wester, Stefan Knop, Katharina Lückerath
Chemokine (C-X-C motif) receptor 4 (CXCR4) is a key factor for tumor growth and metastasis in several types of human cancer including multiple myeloma (MM). Proof-of-concept of CXCR4-directed radionuclide therapy in MM has recently been reported. This study assessed the diagnostic performance of the CXCR4-directed radiotracer [(68)Ga]Pentixafor in MM and a potential role for stratifying patients to CXCR4-directed therapies. Thirty-five patients with MM underwent [(68)Ga]Pentixafor-PET/CT for evaluation of eligibility for endoradiotherapy...
2017: Theranostics
https://www.readbyqxmd.com/read/28034989/serum-b-cell-maturation-antigen-a-novel-biomarker-to-predict-outcomes-for-multiple-myeloma-patients
#9
Michael Ghermezi, Mingjie Li, Suzie Vardanyan, Nika Manik Harutyunyan, Jillian Gottlieb, Ariana Berenson, Tanya M Spektor, Claudia Andreu-Vieyra, Sophia Petraki, Eric Sanchez, Kyle Udd, Cathy S Wang, Regina A Swift, Haiming Chen, James R Berenson
B-cell maturation antigen is expressed on plasma cells. In this study, we have identified serum B-call maturation antigen as a novel biomarker that can monitor and predict outcomes for multiple myeloma patients. Compared to healthy donors, patients with multiple myeloma showed elevated serum B-cell maturation antigen levels (P < 0.0001). Serum B-cell maturation antigen levels correlated with the proportion of plasma cells in bone marrow biopsies (Spearman rho = 0.710; P < 0.001), clinical status (P values: 0...
December 29, 2016: Haematologica
https://www.readbyqxmd.com/read/27941377/68ga-psma-pet-ct-imaging-in-multiple-myeloma
#10
Arun Sasikumar, Ajith Joy, M R A Pillai, Raviteja Nanabala, Boben Thomas
The potential applications of Ga-labeled prostate-specific membrane antigen (PSMA) PET/CT in the imaging of prostate cancer are now well established. A few case reports regarding the potential use of Ga-PSMA PET/CT in nonprostate cancer malignancies are also published. Apparently, the tumor neoangiogenesis is the mechanism attributed to increased Ga-PSMA uptake in the tumor sites in nonprostatic malignancies. We describe the use of Ga-PSMA PET/CT in imaging multiple myeloma. The intense Ga-PSMA avidity of the lesions also opens up the possibility of theranostics with Lu-PSMA...
February 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27922862/improved-detection-of-minimal-residual-disease-by-11c-methionine-pet-ct-in-a-young-patient-with-unusual-extramedullary-presentation-of-recurrent-multiple-myeloma
#11
Carmelo Caldarella, Salvatore Annunziata, Livio Pagano, Valerio De Stefano, Vittoria Rufini
Extramedullary relapse of multiple myeloma (MM) is uncommon. A 40-year-old woman with history of MM underwent PET/CT using C-methionine (C-MET) after the detection of a vulvar lesion on MRI, biopsy proven to be extramedullary relapse of MM. The vulvar lesion was negative at the F-FDG PET/CT but showed high uptake of C-MET; focal uptake of both F-FDG and C-MET was shown within the muscles of the left leg, histologically confirmed as extramedullary relapse of MM. F-FDG PET/CT performed after chemotherapy showed no uptake in both sites, whereas posttreatment C-MET PET/CT showed persistence of residual uptake within the vulvar lesion...
February 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27900520/nuclear-medicine-imaging-of-multiple-myeloma-particularly-in-the-relapsed-setting
#12
REVIEW
Esther G M de Waal, Andor W J M Glaudemans, Carolien P Schröder, Edo Vellenga, Riemer H J A Slart
Multiple myeloma (MM) is characterized by a monoclonal plasma cell population in the bone marrow. Lytic lesions occur in up to 90 % of patients. For many years, whole-body X-ray (WBX) was the method of choice for detecting skeleton abnormalities. However, the value of WBX in relapsing disease is limited because lesions persist post-treatment, which restricts the capacity to distinguish between old, inactive skeletal lesions and new, active ones. Therefore, alternative techniques are necessary to visualize disease activity...
February 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27816878/invasive-granulomatous-cryptococcal-sinusitis-in-an-adult-with-multiple-myeloma
#13
Richard A Ferraro, Jana Ivanidze, Elizabeth Margolskee, Hamilton Tsang, Theresa Sconomiglio, Yuliya S Jhanwar
We report a case of cryptococcal sinusitis, a rare presentation of Cryptococcus neoformans infection in a patient with multiple myeloma. The objective of this case report is to highlight the utility of structural and functional imaging modalities in the differential diagnosis of sinonasal soft tissue masses in the immunocompromised patient population. PET-CT was the first imaging modality in this patient, who presented for routine follow-up staging of multiple myeloma, and was asymptomatic at the time of his presentation...
January 2017: Clinical Imaging
https://www.readbyqxmd.com/read/27775994/the-role-of-68ga-dota-tate-pet-ct-scanning-in-the-evaluation-of-patients-with-multiple-myeloma-preliminary-results
#14
COMPARATIVE STUDY
Kerim Sonmezoglu, Betul Vatankulu, Tugrul Elverdi, Resit Akyel, Melih E Erkan, Metin Halac, Meltem Ocak, Emre Demirci, Yildiz Aydin
OBJECTIVE: In this observational pilot study, we aimed to evaluate the role of gallium-68-labelled DOTA-TATE (Ga-TATE) PET/computed tomography (CT) scanning in patients with multiple myeloma (MM), considering previous promising results obtained from conventional somatostatin receptor scintigraphy with In pentetreotide. MATERIALS AND METHODS: Twenty-one patients with a diagnosis of MM were prospectively included in this study: eight patients were referred for initial staging and 13 patients for restaging purpose...
January 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27761300/extramedullary-plasmacytoma-of-the-gallbladder-detected-on-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#15
Asif Ali Fakhri, Paul David Rodrigue, Amena Fatima Fakhri
Extramedullary plasmacytoma is rare in patients with diagnosed multiple myeloma. Soft tissue plasmacytoma of the gallbladder is particularly uncommon and has been described in only a handful of cases. Diagnosis of gallbladder plasmacytoma with fluorine 18-fluorodeoxyglucose (F18-FDG) positron emission tomography/computed tomography (PET/CT) has not previously been reported. We present a 65-year-old female with a history of multiple myeloma who underwent a restaging F18-FDG-PET/CT which showed a focal area of hypermetabolic activity, corresponding to a nodular lesion within the posterior gallbladder wall...
2016: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/27698001/assessment-of-total-lesion-glycolysis-by-18f-fdg-pet-ct-significantly-improves-prognostic-value-of-gep-and-iss-in-myeloma
#16
James E McDonald, Marcus M Kessler, Michael W Gardner, Amy F Buros, James A Ntambi, Sarah Waheed, Frits van Rhee, Maurizio Zangari, Christoph Heuck, Nathan Petty, Carolina Schinke, Sharmilan Thanendrarajan, Alan Mitchell, Antje Hoering, Bart Barlogie, Gareth Morgan, Faith E Davies
INTRODUCTION: Fluorine-18 fluorodexyglucose positron emission tomography with CT attenuation correction (18F-FDG PET/CT) is useful in the detection and enumeration of focal lesions and in semi-quantitative characterization of metabolic activity (glycolytic phenotype) by calculation of glucose uptake. Total lesion glycolysis (TLG) and metabolic tumor volume (MTV) have the potential to improve the value of this approach and enhance the prognostic value of disease burden measures. This study aims to determine whether TLG and MTV are associated with PFS and OS, and whether they improve risk assessments such as ISS stage and GEP70 risk...
October 3, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27696648/gastrointestinal-histoplasmosis-in-a-patient-after-autologous-stem-cell-transplant-for-multiple-myeloma
#17
Meera Mohan, Bradley Fogel, Thomas Eluvathingal, Carolina Schinke, Atul Kothari
A 59-year-old patient with multiple myeloma on maintenance chemotherapy presented with fever, weight loss, and night sweats. An F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) computed tomography (CT) showed intra-abdominal lymphadenopathy with a mesenteric mass that led to further workup and diagnosis of histoplamosis. The patient was treated with amphotericin B and subsequently switched to itraconazole. This exemplifies the usefulness of FDG PET CT in diagnosis of infectious complications...
December 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27692305/the-combined-role-of-biomarkers-and-interim-pet-scan-in-prediction-of-treatment-outcome-in-classical-hodgkin-s-lymphoma-a-retrospective-european-multicentre-cohort-study
#18
Claudio Agostinelli, Andrea Gallamini, Luisa Stracqualursi, Patrizia Agati, Claudio Tripodo, Fabio Fuligni, Maria Teresa Sista, Stefano Fanti, Alberto Biggi, Umberto Vitolo, Luigi Rigacci, Francesco Merli, Caterina Patti, Alessandra Romano, Alessandro Levis, Livio Trentin, Caterina Stelitano, Anna Borra, Pier Paolo Piccaluga, Stephen Hamilton-Dutoit, Peter Kamper, Jan Maciej Zaucha, Bogdan Małkowski, Waldemar Kulikowski, Joanna Tajer, Edyta Subocz, Justyna Rybka, Christian Steidl, Alessandro Broccoli, Lisa Argnani, Randy D Gascoyne, Francesco d'Amore, Pier Luigi Zinzani, Stefano A Pileri
BACKGROUND: Early-interim fluorodeoxyglucose (FDG)-PET scan after two ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) chemotherapy courses (PET-2) represents the most effective predictor of treatment outcome in classical Hodgkin's lymphoma. We aimed to assess the predictive value of PET-2 combined with tissue biomarkers in neoplastic and microenvironmental cells for this disease. METHODS: We enrolled 208 patients with classical Hodgkin's lymphoma and treated with ABVD (training set), from Jan 1, 2002, to Dec 31, 2009, and validated the results in a fully matched independent cohort of 102 patients with classical Hodgkin's lymphoma (validation set), enrolled from Jan 1, 2008, to Dec 31, 2012...
October 2016: Lancet Haematology
https://www.readbyqxmd.com/read/27680220/successful-surgical-resection-of-solitary-plasmacytoma-of-the-liver-mimicking-hepatocellular-carcinoma-a-case-report
#19
Mariateresa Mirarchi, Emilio De Raffele, Francesco Bacci, Dajana Cuicchi, Ferdinando Lecce, Bruno Cola
Solitary extramedullary plasmacitomas (SEMP) of the liver are very rare. We report the case of an elderly woman with a huge symptomatic SEMP of the liver mimicking hepatocellular carcinoma (HCC). The patient was a 89-year-old woman who presented with severe abdominal pain and a huge solid mass in the right hypochondrium. The laboratory data on admission revealed normal liver function tests. A multiphasic computed tomography (CT) showed a huge solid mass of the left hemiliver, hypoattenuating on noncontrast images, dishomogeneously hyperenhancing in the late arterial phase, with washout in the portal venous and equilibrium phases...
2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27651943/solitary-plasmacytoma-of-the-mandible-an-uncommon-entity
#20
Ezher Hamza Dayisoylu, Ozcan Ceneli, Esra Zeypep Coskunoglu
INTRODUCTION: Plasma cell dyscrasias are characterized by a monoclonal neoplastic proliferation of plasma cells. Solitary bone plasmacytoma (SBP) is a local form of the disease with the vertebrae and long bones being the most frequently encountered sites. Its prevalence in the maxillofacial area is extremely rare. CASE PRESENTATION: A 70-year-old Caucasian male patient was referred for the extraction of his mobile premolar tooth with a poorly-defined radiolucent lesion...
July 2016: Iranian Red Crescent Medical Journal
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