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https://www.readbyqxmd.com/read/28100813/coral-calcifying-fluid-ph-is-modulated-by-seawater-carbonate-chemistry-not-solely-seawater-ph
#1
S Comeau, E Tambutté, R C Carpenter, P J Edmunds, N R Evensen, D Allemand, C Ferrier-Pagès, S Tambutté, A A Venn
Reef coral calcification depends on regulation of pH in the internal calcifying fluid (CF) in which the coral skeleton forms. However, little is known about calcifying fluid pH (pHCF) regulation, despite its importance in determining the response of corals to ocean acidification. Here, we investigate pHCF in the coral Stylophora pistillata in seawater maintained at constant pH with manipulated carbonate chemistry to alter dissolved inorganic carbon (DIC) concentration, and therefore total alkalinity (AT). We also investigate the intracellular pH of calcifying cells, photosynthesis, respiration and calcification rates under the same conditions...
January 25, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28098180/an-aposymbiotic-primary-coral-polyp-counteracts-acidification-by-active-ph-regulation
#2
Yoshikazu Ohno, Akira Iguchi, Chuya Shinzato, Mayuri Inoue, Atsushi Suzuki, Kazuhiko Sakai, Takashi Nakamura
Corals build their skeletons using extracellular calcifying fluid located in the tissue-skeleton interface. However, the mechanism by which corals control the transport of calcium and other ions from seawater and the mechanism of constant alkalization of calcifying fluid are largely unknown. To address these questions, we performed direct pH imaging at calcification sites (subcalicoblastic medium, SCM) to visualize active pH upregulation in live aposymbiotic primary coral polyps treated with HCl-acidified seawater...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28096040/calcium-a-predictor-of-interventional-treatment-failure-across-all-fields-of-cardiovascular-medicine
#3
EDITORIAL
Alessio Mattesini, Carlo Di Mario
In this substudy of the ADAPT-DES trial Généreux et al. compared two years outcomes according to the presence or absence of coronary artery calcification (CAC) as assessed by coronary angiography. Coronary calcification was an independent predictor of interventional treatment failure and a higher incidence of both ischemic events and bleeding. The cohort with CAC was older with a higher prevalence of risk factors and comorbidities and an increased anatomical complexity of the target lesions, explaining only in part the worse outcome of the CAC population that persisted at multivariate analysis...
January 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28091516/osteopontin-regulates-macrophage-activation-and-osteoclast-formation-in-hypertensive-patients-with-vascular-calcification
#4
Qian Ge, Cheng-Chao Ruan, Yu Ma, Xiao-Feng Tang, Qi-Hong Wu, Ji-Guang Wang, Ding-Liang Zhu, Ping-Jin Gao
Vascular calcification (VC) is a highly regulated ectopic mineral deposition process involving immune cell infiltration in the vasculatures, which has been recognized to be promoted by hypertension. The matricellular glycoprotein osteopontin (OPN) is strongly induced in myeloid cells as a potential inflammatory mediator of vascular injury. This study aims to examine whether OPN is involved in the regulation of macrophage activation and osteoclast formation in hypertensive subjects with VC. We firstly found an increased proportion of CD11c+CD163- pro-inflammatory peripheral monocytes in hypertensive subjects with VC compared to those without VC by flow cytometric analysis...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28089999/impact-of-impaired-renal-function-in-patients-with-severely-calcified-coronary-lesions-treated-with-orbital-atherectomy
#5
Michael S Lee, Evan Shlofmitz, Gentian Lluri, Richard A Shlofmitz
OBJECTIVES: We evaluated the clinical outcomes of patients with chronic kidney disease (CKD) who underwent orbital atherectomy for severe coronary artery calcification (CAC) prior to stent implantation. BACKGROUND: Percutaneous coronary intervention (PCI) of lesions with severe CAC is associated with increased rates of adverse clinical events. Patients with CKD are at increased risk for atherosclerotic cardiovascular disease, including vascular calcification, and have worse outcomes after PCI...
January 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28089254/volumetric-analysis-of-carotid-plaque-components-and-cerebral-microbleeds-a-correlative-study
#6
Luca Saba, Roberto Sanfilippo, Michele di Martino, Michele Porcu, Roberto Montisci, Pierleone Lucatelli, Michele Anzidei, Marco Francone, Jasjit S Suri
PURPOSE: The purpose of this work was to explore the association between carotid plaque volume (total and the subcomponents) and cerebral microbleeds (CMBs). MATERIALS AND METHODS: Seventy-two consecutive (male 53; median age 64) patients were retrospectively analyzed. Carotid arteries were studied by using a 16-detector-row computed tomography scanner whereas brain was explored with a 1.5 Tesla system. CMBs were studied using a T2*-weighted gradient-recalled echo sequence...
January 11, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28077820/acute-coronary-syndrome-demonstrating-plaque-rupture-in-calcified-lesions-visualized-by-optical-frequency-domain-imaging
#7
Yutaka Goryo, Teruyoshi Kume, Yusuke Kobayashi, Hiroshi Okamoto, Ai Kawamura, Kenzo Fukuhara, Terumasa Koyama, Ryotaro Yamada, Koichiro Imai, Yoji Neishi, Shiro Uemura
A 68-year-old female with acute coronary syndrome was transferred to our hospital. Emergency coronary angiography showed 90% stenosis with severe calcification in the proximal right coronary artery (RCA). Intravascular ultrasound (IVUS) images were obtained and showed circumferential heavy calcification without any evidence of plaque rupture. Optical frequency domain imaging (OFDI) images were obtained in the RCA lesion 3 days after the initial coronary angiography. A cavity of plaque rupture in the calcified plaque by using OFDI was observed in the lesion, which could not be recognized by IVUS...
January 11, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28072390/a-molecular-portrait-of-maternal-sepsis-from-byzantine-troy
#8
Alison M Devault, Tatum D Mortimer, Andrew Kitchen, Henrike Kiesewetter, Jacob M Enk, G Brian Golding, John Southon, Melanie Kuch, Ana T Duggan, William Aylward, Shea N Gardner, Jonathan E Allen, Andrew M King, Gerard Wright, Makoto Kuroda, Kengo Kato, Derek Eg Briggs, Gino Fornaciari, Edward C Holmes, Hendrik N Poinar, Caitlin S Pepperell
Pregnancy complications are poorly represented in the archeological record, despite their importance in contemporary and ancient societies. While excavating a Byzantine cemetery in Troy, we discovered calcified abscesses among a woman's remains. Scanning electron microscopy of the tissue revealed 'ghost cells', resulting from dystrophic calcification, which preserved ancient maternal, fetal and bacterial DNA of a severe infection, likely chorioamnionitis. Gardnerella vaginalis and Staphylococcus saprophyticus dominated the abscesses...
January 10, 2017: ELife
https://www.readbyqxmd.com/read/28057994/a-completely-calcified-prostate
#9
Vinod Priyadarshi, Nidhi Sehgal
Prostatic calcification and prostatic calculus formation is commonly seen in adult population with chronic prostatitis, however, gross prostatic calcification which involves more than 3 cm(2) of the gland is quite rare. We are presenting here one such case in which almost whole glandular prostate was converted into stone which is never reported so far.
October 2016: Urology Annals
https://www.readbyqxmd.com/read/28050378/large-cell-calcifying-sertoli-cell-tumour-of-testis-a-rare-case-report
#10
Harresh Kumar, Nadeem Tanveer, Natasha Gupta, Kiran Mishra
Sertoli cell tumours of testes are classified into sertoli cell tumour NOS (not otherwise specified), sclerosing variant and large cell calcifying variant. So far, 90 cases of the large cell calcifying variant have been reported in literature. We describe a rare case of inhibin negative locally invasive large cell calcifying sertoli cell tumour of testis. A 62-year-old man presented with complaints of pain and swelling in right scrotum for 8 months. Ultrasound revealed a right testicular mass with internal vascularity and calcification...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28048959/expression-and-localization-of-carbonic-anhydrase-genes-in-the-serpulid-polychaete-hydroides-elegans
#11
Grant Batzel, Brian T Nedved, Michael G Hadfield
The metalloenzyme, carbonic anhydrase (CA), catalyzes the reversible hydration of carbon dioxide into bicarbonate, and is responsible for biomineralization processes in animals. In the Annelida, the marine worms in the family Serpulidae are typified by the construction of calcium carbonate tubes. Hydroides elegans, a common member of warmwater biofouling communities around the world, provides an outstanding model for studies of calcification. To better understand the molecular process of biomineralization in H...
December 2016: Biological Bulletin
https://www.readbyqxmd.com/read/28045673/orbital-atherectomy-in-the-renal-artery-a-new-frontier-for-an-emerging-technology
#12
Javier A Valle, Ehrin J Armstrong, Stephen W Waldo
Orbital atherectomy has been developed as a method to modify calcified plaque in the peripheral vasculature, with extensive experience and data supporting its use in infrainguinal peripheral arterial disease. However, calcific atherosclerotic disease occurs in other vascular beds and may benefit from the application of this technology. In this case report, we describe the first reported use of orbital atherectomy in a renal artery. A 55-year-old male with severe drug-refractory hypertension was found to have renal artery stenosis, with severe calcification of the right renal artery...
January 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28040289/two-year-outcomes-after-percutaneous-coronary-intervention-of-calcified-lesions-with-drug-eluting-stents
#13
Philippe Généreux, Björn Redfors, Bernhard Witzenbichler, Marie-Pier Arsenault, Giora Weisz, Thomas D Stuckey, Michael J Rinaldi, Franz-Josef Neumann, D Christopher Metzger, Timothy D Henry, David A Cox, Peter L Duffy, Ernest L Mazzaferri, Dominic P Francese, Guillaume Marquis-Gravel, Gary S Mintz, Ajay J Kirtane, Akiko Maehara, Roxana Mehran, Gregg W Stone
BACKGROUND: Percutaneous coronary intervention (PCI) of lesions with coronary arterial calcification (CAC) is common and has been historically associated with an increased risk of adverse events. Whether the association between target lesion calcification (CAC) and outcomes differ across drug-eluting stent generation or between patients with high vs. low residual platelet reactivity (PR) remains unknown. We assessed the association of CAC with adverse ischemic and bleeding events among patients undergoing contemporary PCI with drug-eluting stents (DES)...
December 26, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28039339/concomitant-mitral-annular-calcification-and-severe-aortic-stenosis-prevalence-characteristics-and-outcome-following-transcatheter-aortic-valve-replacement
#14
Yigal Abramowitz, Yoshio Kazuno, Tarun Chakravarty, Hiroyuki Kawamori, Yoshio Maeno, David Anderson, Zev Allison, Geeteshwar Mangat, Wen Cheng, Ambarish Gopal, Hasan Jilaihawi, Michael J Mack, Raj R Makkar
AIMS: Calcified aortic stenosis (AS) and mitral annular calcification (MAC) have certain similar etiology and pathophysiological mechanisms. MAC is frequently encountered in pre-procedural computed tomography (CT) imaging of patients that undergo transcatheter aortic valve replacement (TAVR), but its prognostic implications for these patients have not been thoroughly investigated. This study sought to evaluate the prevalence of MAC among patients with severe AS and to assess the clinical implications of MAC on these patients during and following TAVR...
December 30, 2016: European Heart Journal
https://www.readbyqxmd.com/read/28033680/calcification-of-the-lower-respiratory-tract-in-relation-to-flight-development-in-jamaican-fruit-bats-phyllostomidae-artibeus-jamaicensis
#15
Richard T Carter
The production of echolocation calls in bats along with forces produced by contraction of thoracic musculature used in flight presumably puts relatively high mechanical loads on the lower respiratory tract (LRT). Thus, there are likely adaptations to prevent collapse or distortion of the bronchial tree and trachea during flight in echolocating bats. By clearing and staining (Alcian blue and Alizarin red) LRTs removed from nonvolant neonates, semivolant juveniles, volant subadults, and adult Jamaican fruit bats (Artibeus jamaicensis), I found that calcification of the tracheal, primary bronchial, and secondary bronchial (lobar) cartilage rings occurs over the span of about 3 days and coincides with later developmental stages of flight and the increased production of echolocation calls...
December 29, 2016: Journal of Anatomy
https://www.readbyqxmd.com/read/28027751/a-matrix-of-morphology-and-distribution-of-calcifications-in-the-breast-analysis-of-849-vacuum-assisted-biopsies
#16
Benjamin Kaltenbach, Volker Brandenbusch, Volker Möbus, Gerhard Mall, Stephan Falk, Marcus van den Bergh, Frauke Chevalier, Markus Müller-Schimpfle
OBJECTIVE: The purpose of this retrospective analysis was to evaluate the likelihood of malignancy in prospectively categorized BI-RADS 4 and BI-RADS 5 calcifications. MATERIAL AND METHODS: This analysis included 849 women who underwent vacuum biopsy for BI-RADS 4 (with the subgroups 4A, 4B and 4C) or BI-RADS 5 calcifications between February 2007 and May 2015. Calcifications were classified according to the morphology and distribution descriptors of the BI-RADS lexicon (BI-RADS 4th edition lexicon)...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28027749/pancreatic-cancer-in-patients-with-chronic-calcifying-pancreatitis-computed-tomography-findings-a-retrospective-analysis-of-48-patients
#17
Amir Mohamed, Ahmet Ayav, Arthur Belle, Xavier Orry, Jean-Baptiste Chevaux, Valerie Laurent
OBJECTIVE: Chronic calcifying pancreatitis (CCP) is a risk factor for pancreatic cancer (PC). Symptoms of PC are non-specific in patients with CCP, and diagnostic imaging can be difficult. Some studies have shown that diagnosis may take several months, leading to delays in treatment (Lin et al., 2015; Lennon et al., 2014) [2,3]. The aim of this study was to describe the radiological signs of PC in patients with CCP. METHODS: This retrospective, single-center study was conducted between January 2004 and December 2014...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28025437/diverse-calcification-patterns-of-ameloblastic-fibro-odontoma-on-radiographic-examination
#18
Masao Araki, Shunsuke Namaki, Toshihiko Amemiya, Kunihito Matsumoto, Kazuya Honda, Yoshiyuki Yonehara, Naoyuki Matsumoto, Masatake Asano
The occurrence of ameloblastic fibro-odontoma (AFO) in the oral region is unusual and accounts for 1-3% of all odontogenic tumors. AFO presents mixed radiopaque patterns within the lesion with diverse findings; therefore, it is important to compare this tumor with other odontogenic tumors that radiographically present with calcified bodies. Herein, we observed the calcification patterns within the lesion in seven AFO cases (five males, two females; mean age, 8.3 years; age range, 4-13 years). Periapical and panoramic radiographs were obtained from all seven cases...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/28024939/rage-deficiency-alleviates-aortic-valve-calcification-in-apoe-mice-via-the-inhibition-of-endoplasmic-reticulum-stress
#19
Bo Wang, Zhejun Cai, Baoqing Liu, Zongtao Liu, Xianming Zhou, Nianguo Dong, Fei Li
Receptor for advanced glycation end products (RAGE) and endoplasmic reticulum (ER) stress have been shown to be involved in calcific aortic valve disease (CAVD). However, the association between RAGE and ER stress remains unknown in the pathogenesis of CAVD. The current study aims to test the hypothesis that RAGE deficiency alleviates aortic valve calcification via the inhibition of ER stress. Up-regulation of RAGE and ER stress markers in calcified human aortic valves were confirmed by immunoblotting. Aortic valve calcification was evaluated in atherosclerotic prone ApoE(-/-) mice or in mice with dual deficiencies of ApoE and RAGE (ApoE(-/-)RAGE(-/-)) fed with high cholesterol diet for 24weeks...
December 24, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28017543/cost-effectiveness-analysis-of-the-orbital-atherectomy-system-two-year-follow-up
#20
Louis P Garrison, Marita R Zimmermann, Christopher H Young, Janna Crittendon, Philippe Généreux
BACKGROUND: The presence of coronary artery calcification is associated with a significant burden of coronary artery disease along with being a predictor of increased adverse ischemic events. The Diamondback 360® Coronary Orbital Atherectomy System (OAS) is a novel device designed to facilitate treatment of calcified lesions. This study aimed to evaluate the cost-effectiveness of OAS compared to standard treatment. METHODS: A decision tree model utilizing ORBIT II clinical trial and Medicare data from the health system perspective was constructed...
December 15, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
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