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https://www.readbyqxmd.com/read/27911025/effect-of-balloon-expandable-transcatheter-aortic-valve-replacement-positioning-a-patient-specific-numerical-model
#1
Matteo Bianchi, Gil Marom, Ram P Ghosh, Harold A Fernandez, James R Taylor, Marvin J Slepian, Danny Bluestein
Transcatheter aortic valve replacement (TAVR) has emerged as a life-saving and effective alternative to surgical valve replacement in high-risk, elderly patients with severe calcific aortic stenosis. Despite its early promise, certain limitations and adverse events, such as suboptimal placement and valve migration, have been reported. In the present study, it was aimed to evaluate the effect of various TAVR deployment locations on the procedural outcome by assessing the risk for valve migration. The deployment of a balloon-expandable Edwards SAPIEN valve was simulated via finite element analysis in a patient-specific calcified aortic root, which was reconstructed from CT scans of a retrospective case of valve migration...
December 2016: Artificial Organs
https://www.readbyqxmd.com/read/27904840/surgical-experience-on-chronic-constrictive-pericarditis-in-african-setting-review-of-35-years-experience-in-cote-d-ivoire
#2
Koffi Herve Yangni-Angate, Yves Tanauh, Christophe Meneas, Florent Diby, Anicet Adoubi, Manga Diomande
BACKGROUND: Surgical experience with chronic constrictive pericarditis (CCP) is rarely documented in Africa; the aim of this study is therefore to review our African experience with CCP from 1977 to 2012 in terms of clinical and surgical outcomes and risk factors of early death after pericardiectomy. METHODS: This retrospective study is related to 120 patients with CCP; there were 72 men and 48 women with an average age at 28.8±10.4 years standard deviation (SD) (8-51 years)...
October 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/27903375/-in-vivo-and-in-vitro-effects-of-cd137-stimulation-on-vascular-calcification-in-high-fat-diet-fed-apoe-mice
#3
Y Chen, J C Yan, J Y Weng, Z Q Wang, C P Wang, C Shao
Objective: To investigate the effect and related mechanism of CD137 stimulation on aortic atherosclerotic plaque calcification in high fat diet fed ApoE(-/-) mice and on calcification of vascular smooth muscle cells (VSMCs). Methods: (1) ApoE(-/-) mice fed with high fat diet were randomly divided into 3 groups: CD137 activated group (treated by 200 μg CD137 agonist i. p. once per week for 6 weeks, n=5); CD137 inhibited group (anti-CD137 group: 200 μg anti-CD137 antibody + 200 μg CD137 agonist, i. p., once per week for 6 weeks, n=5) and control group (n=5)...
October 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27903019/osteochondroma-presenting-as-a-calcified-mass-in-the-sellar-region-and-review-of-the-literature
#4
Kazuya Sekiguchi, Satoshi Tsutsumi, Sho Arai, Senshu Nonaka, Takamoto Suzuki, Hisato Ishii, Hiroshi Izumi, Yukimasa Yasumoto
Objective Osteochondroma (OC) is the most common benign bone neoplasm. It infrequently occurs in the cranial cavity as a calcified lesion and very rarely presents in the sellar region. The present study summarizes the knowledge about OCs of the sellar region. Methods We searched the literature search for the clinical appearance of OCs and other calcified pathologies occurring in the sellar region. Results A total of 21 English-language articles published from 1961 to 2015 documented cases of calcified lesions in the sellar region including cerebral aneurysm, chondroid chordoma, chondroma, craniopharyngioma, OC, odontome, osteoma, pituitary adenoma, pituitary stone, Rathke cleft cyst, retinoblastoma, schwannoma, and xanthogranuloma...
November 30, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27894264/optical-coherence-tomography-findings-after-longitudinal-ablation-for-an-underexpanded-stent-in-a-heavily-calcified-lesion-a-case-report
#5
Masahiro Koide, Keiji Inoue, Akiko Matsuo, Hiroshi Fujita
BACKGROUND: Heavy coronary artery calcification is responsible for stent underexpansion, which is associated with increased in-stent restenosis. Here we report a case in which optical coherence tomography (OCT) demonstrated that the metal component of an underexpanded stent previously implanted in a heavy calcified lesion had been completely removed after ablation with rotational atherectomy. CASE PRESENTATION: An 83-year-old man with exertional angina was referred to our hospital...
November 29, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27887791/cryptogenic-stroke-and-nonstenosing-intracranial-calcified-atherosclerosis
#6
Hooman Kamel, Gino Gialdini, Hediyeh Baradaran, Ashley E Giambrone, Babak B Navi, Michael P Lerario, James K Min, Costantino Iadecola, Ajay Gupta
OBJECTIVE: Because some cryptogenic strokes may result from large-artery atherosclerosis that goes unrecognized as it causes <50% luminal stenosis, we compared the prevalence of nonstenosing intracranial atherosclerotic plaques ipsilateral to cryptogenic cerebral infarcts versus the unaffected side using imaging biomarkers of calcium burden. METHODS: In a prospective stroke registry, we identified patients with cerebral infarction limited to the territory of one internal carotid artery (ICA)...
November 23, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27887725/a-calcified-polymeric-valve-for-valve-in-valve-applications
#7
Ahmad Falahatpisheh, Daisuke Morisawa, Taraz T Toosky, Arash Kheradvar
The prevalence of aortic valve stenosis (AS) is increasing in the aging society. More recently, novel treatments and devices for AS, especially transcatheter aortic valve replacement (TAVR) have significantly changed the therapeutic approach to this disease. Research and development related to TAVR require testing these devices in the calcified heart valves that closely mimic a native calcific valve. However, no animal model of AS has yet been available. Alternatively, animals with normal aortic valve that are currently used for TAVR experiments do not closely replicate the aortic valve pathology required for proper testing of these devices...
November 16, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27873740/response-to-the-anastrozole-treatment-in-a-case-with-peutz-jeghers-syndrome-who-was-detected-to-have-large-cell-calcifying-sertoli-cell-tumor-and-developed-pre-pubertal-gynecomastia
#8
Merve Koç Yekedüz, Zeynep Şıklar, Berk Burgu, Zarife Kuloğlu, Pınar Kocaay, Emine Çamtosun, Mehmet İsakoca, Aydan Kansu, Tarkan Soygür, Merih Berberoğlu
Peutz-Jeghers Syndrome (PJS) is inherited as an autosomal dominant trait which is characterized by multiple gastrointestinal hamartomatous polyps, mucocutaneous pigmentation, and an increased risk of neoplasm. Large Cell Calcifying Sertoli Cell Tumor (LCCSCT) is a kind of sex cord-stromal tumor, often bilateral and multifocal, accounting for 0.4 -1.5% of entire testicular tumors which may co-exist with PJS and is characterized radiologically by calcification foci within the testes. Surgical treatment options for this tumor range from testis-preserving surgery to radical orchiectomy...
November 22, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/27873060/reinforced-mitral-valve-replacement-using-a-xenopericardium-collared-prosthetic-valve-for-a-heavily-calcified-or-disrupted-mitral-annulus-a-simple-dumpling-technique
#9
Masaru Ishida, Koichi Toda, Teruya Nakamura, Shigeru Miyagawa, Yasushi Yoshikawa, Satsuki Fukushima, Shunsuke Saito, Takayoshi Ueno, Toru Kuratani, Yoshiki Sawa
Heavy mitral annular calcification or severe destruction of the mitral annulus in the setting of mitral valve replacement may result in fatal complications, such as atrioventricular disruption, ventricular rupture, valve dehiscence, and perivalvular leakage. Collar-reinforced mitral valve replacements with xenopericardium have been reported to prevent perivalvular leakage and valve detachment. We herein describe our experience with an easy method of handling the modified collar-reinforced prosthetic valve, which we call the "Dumpling technique", in six patients...
November 21, 2016: Surgery Today
https://www.readbyqxmd.com/read/27867942/quantification-of-calcified-particles-in-human-valve-tissue-reveals-asymmetry-of-calcific-aortic-valve-disease-development
#10
Katsumi Yabusaki, Joshua D Hutcheson, Payal Vyas, Sergio Bertazzo, Simon C Body, Masanori Aikawa, Elena Aikawa
Recent studies indicated that small calcified particles observable by scanning electron microscopy (SEM) may initiate calcification in cardiovascular tissues. We hypothesized that if the calcified particles precede gross calcification observed in calcific aortic valve disease (CAVD), they would exhibit a regional asymmetric distribution associated with CAVD development, which always initiates at the base of aortic valve leaflets adjacent to the aortic outflow in a region known as the fibrosa. Testing this hypothesis required counting the calcified particles in histological sections of aortic valve leaflets...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27867529/coexistence-of-apical-hypertrophic-cardiomyopathy-and-endomyocardial-fibrosis-with-calcification-diagnosis-using-multimodality-imaging
#11
Lakshmi Muthukumar, M Fuad Jan, Joseph Whitnah, A Jamil Tajik
A 48-year-old man from West Africa was evaluated for dyspnea. Echocardiography showed an echolucent mass at the left ventricular apex surrounded by a dense ridge of tissue, suggesting endomyocardial fibrosis (EMF). Doppler echocardiography showed restrictive hemodynamics and intramyocardial coronary blood flow at the hypertrophied apex, suggesting apical hypertrophic cardiomyopathy (ApHCM) with calcified thrombus. Cardiac magnetic resonance imaging showed a thickened myocardium with apical cavity obliteration and endomyocardial calcification, and gadolinium contrast demonstrated marked bright subendocardial and diffuse patchy intramyocardial hyperenhancement in the hypertrophied apical wall segment, confirming coexistence of EMF and ApHCM...
December 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27867142/impact-of-plaque-type-and-side-branch-geometry-on-side-branch-compromise-after-provisional-stent-implantation-a-simulation-study
#12
Francesco Iannaccone, Claudio Chiastra, Antonios Karanasos, Francesco Migliavacca, Frank J H Gijsen, Patrick Segers, Peter Mortier, Benedict Verhegghe, Gabriele Dubini, Matthieu De Beule, Evelyn Regar, Jolanda J Wentzel
AIMS: Mechanisms of lumen compromise after provisional side-branch (SB) stenting are poorly understood. In this study we investigated the impact of bifurcation angle, plaque composition, and procedural strategy on SB compromise. METHODS AND RESULTS: Computer simulations of stent implantation were performed in Medina (1,1,1) bifurcation models. Provisional SB stenting was replicated including post-dilation after main branch stenting. Two bifurcation angles (45°,70°) and four plaque types (fully lipid, fully fibrous, lipid with half and full calcified ring distal to the carina) were tested...
November 22, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27867140/impact-of-calcified-bifurcation-lesions-in-patients-undergoing-percutaneous-coronary-intervention-using-drug-eluting-stents-results-from-the-coronary-bifurcation-stent-cobis-ii-registry
#13
Min Chul Kim, Youngkeun Ahn, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Hyeon-Cheol Gwon, Hyo-Soo Kim, Seung Woon Rha, Jung Han Yoon, Yangsoo Jang, Seung-Jea Tahk, Ki Bae Seun
AIMS: Few data regarding clinical outcomes according to severity of calcification in patients with coronary bifurcation target lesions are available. METHODS AND RESULTS: This prospective, multicenter, observational registry enrolled 2,897 patients undergoing percutaneous coronary intervention with drug-eluting stents for coronary bifurcation lesions. We compared target lesion failure (TLF), defined as a composite of cardiac death, non-fatal myocardial infarction (MI), and target lesion revascularization (TLR), according to severity of calcification in coronary bifurcation target lesions, assessed by an angiographic core laboratory using quantitative coronary angiography...
November 22, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27867037/cardiac-fibroblasts-adopt-osteogenic-fates-and-can-be-targeted-to-attenuate-pathological-heart-calcification
#14
Indulekha C L Pillai, Shen Li, Milagros Romay, Larry Lam, Yan Lu, Jie Huang, Nathaniel Dillard, Marketa Zemanova, Liudmilla Rubbi, Yibin Wang, Jason Lee, Ming Xia, Owen Liang, Ya-Hong Xie, Matteo Pellegrini, Aldons J Lusis, Arjun Deb
Mammalian tissues calcify with age and injury. Analogous to bone formation, osteogenic cells are thought to be recruited to the affected tissue and induce mineralization. In the heart, calcification of cardiac muscle leads to conduction system disturbances and is one of the most common pathologies underlying heart blocks. However the cell identity and mechanisms contributing to pathological heart muscle calcification remain unknown. Using lineage tracing, murine models of heart calcification and in vivo transplantation assays, we show that cardiac fibroblasts (CFs) adopt an osteoblast cell-like fate and contribute directly to heart muscle calcification...
November 15, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/27865804/ghost-cell-tumors
#15
Jason Sheikh, Molly D Cohen, Naomi Ramer, Ali Payami
Ghost cell tumors are a family of lesions that range in presentation from cyst to solid neoplasm and in behavior from benign to locally aggressive or metastatic. All are characterized by the presence of ameloblastic epithelium, ghost cells, and calcifications. This report presents the cases of a 14-year-old girl with a calcifying cystic odontogenic tumor (CCOT) and a 65-year-old woman with a peripheral dentinogenic ghost cell tumor (DGCT) with dysplastic changes, a rare locally invasive tumor of odontogenic epithelium...
October 26, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27862397/multiple-calcifying-pseudoneoplasms-of-the-neuraxis-mcapnon-distinct-entity-capnon-variant-or-old-neurocysticercosis
#16
Maram Abdaljaleel, Rajarshi Mazumder, Chirag B Patel, Kyuseok Im, Whitney Pope, Linda M Liau, Harry V Vinters, William H Yong
We report a case of multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON) with associated multifocal perivascular microcalcifications and vascular calcinosis. Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a very rare condition that may arise in extra-axial and occasionally, in intra-axial locations. Moreover, it is nearly always a solitary mass with only one case with two lesions reported. While the etiology and pathogenesis of CAPNON remains unclear, the histopathology findings of this entity have been well described...
November 10, 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/27862258/raine-syndrome-omim-259775-caused-by-fam20c-mutation-is-congenital-sclerosing-osteomalacia-with-cerebral-calcification-omim-259660
#17
Michael P Whyte, William H McAlister, Michael D Fallon, Mary Ella Pierpont, Vinieth N Bijanki, Shenghui Duan, Ghada A Otaify, William S Sly, Steven Mumm
In 1985, we briefly reported infant sisters with a unique, lethal, autosomal recessive disorder designated congenital sclerosing osteomalacia with cerebral calcification. In 1986, this condition was entered into Mendelian Inheritance In Man (MIM) as osteomalacia, sclerosing, with cerebral calcification (MIM 259660). However, no attestations followed. Instead, in 1989 Raine and colleagues published an affected neonate considering unprecedented the striking clinical and radiographic features. In 1992, "Raine syndrome" entered MIM formally as osteosclerotic bone dysplasia, lethal (MIM #259775)...
November 10, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27859162/geographic-extent-and-variation-of-a-coral-reef-trophic-cascade
#18
T R McClanahan, N A Muthiga
Trophic cascades caused by a reduction in predators of sea urchins have been reported in Indian Ocean and Caribbean coral reefs. Previous studies have been constrained by their site-specific nature and limited spatial replication, which has produced site and species-specific understanding that can potentially preclude larger community-organization nuances and generalizations. In this study, we aimed to evaluate the extent and variability of the cascade community in response to fishing across ~23° of latitude and longitude in coral reefs in the southwestern Indian Ocean...
July 2016: Ecology
https://www.readbyqxmd.com/read/27856308/dysregulation-of-hyaluronan-homeostasis-during-aortic-valve-disease
#19
Varun K Krishnamurthy, Andrew J Stout, Matthew C Sapp, Brittany Matuska, Mark E Lauer, K Jane Grande-Allen
Aortic valve disease (AVD) is one of the leading causes of cardiovascular mortality. Abnormal expression of hyaluronan (HA) and its synthesizing/degrading enzymes have been observed during latent AVD however, the mechanism of impaired hyaluronan homeostasis prior to and after the onset of AVD remains unexplored. Transforming growth factor beta (TGFβ) pathway defects and biomechanical dysfunction are hallmarks of AVD, however their association with altered hyaluronan regulation is understudied. Expression of HA homeostatic markers was evaluated in diseased human aortic valves and TGFβ1-cultured porcine aortic valve tissues using histology, immunohistochemistry and Western blotting...
November 14, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27848163/myocardial-ischemia-detection-with-single-phase-ct-perfusion-in-symptomatic-patients-using-high-pitch-helical-image-acquisition-technique
#20
Bernhard Bischoff, Simon Deseive, Martin Rampp, Andrei Todica, Marc Wermke, Stefan Martinoff, Steffen Massberg, Maximilian F Reiser, Hans-Christoph Becker, Jörg Hausleiter
Coronary CT angiography (CCTA) suffers from a reduced diagnostic accuracy in patients with heavily calcified coronary arteries or prior myocardial revascularisation due to artefacts caused by calcifications and stent material. CT myocardial perfusion imaging (CTMPI) yields high potential for the detection of myocardial ischemia and might help to overcome the above mentioned limitations. We analysed CT single-phase perfusion using high-pitch helical image acquisition technique in patients with prior myocardial revascularisation...
November 15, 2016: International Journal of Cardiovascular Imaging
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