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calcification calcified

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https://www.readbyqxmd.com/read/28641846/conduction-abnormalities-and-permanent%C3%A2-pacemaker-implantation-after-transcatheter-aortic-valve-replacement-using-the-repositionable-lotus-device-the-united-kingdom-experience
#1
Rajiv Rampat, M Zeeshan Khawaja, Roland Hilling-Smith, Jonathan Byrne, Philip MacCarthy, Daniel J Blackman, Arvindra Krishnamurthy, Ashan Gunarathne, Jan Kovac, Adrian Banning, Raj Kharbanda, Sami Firoozi, Stephen Brecker, Simon Redwood, Vinayak Bapat, Michael Mullen, Suneil Aggarwal, Ganesh Manoharan, Mark S Spence, Saib Khogali, Maureen Dooley, James Cockburn, Adam de Belder, Uday Trivedi, David Hildick-Smith
OBJECTIVES: The authors report the incidence of pacemaker implantation up to hospital discharge and the factors influencing pacing rate following implantation of the LOTUS bioprosthesis (Boston Scientific, Natick, Massachusetts) in the United Kingdom. BACKGROUND: Transcatheter aortic valve replacement (TAVR) is associated with a significant need for permanent pacemaker implantation. Pacing rates vary according to the device used. The REPRISE II (Repositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus Valve System) trial reported a pacing rate of 29% at 30 days after implantation of the LOTUS device...
June 26, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28632669/effect-of-low-intensity-pulsed-ultrasound-lipus-on-endochondral-ossification-via-the-wnt-signaling-pathway
#2
Ken Kumagai, Yasuteru Yamaguchi, Kazuma Miyatake, Hironori Tanabe, Sosuke Imai, Tomoyuki Saito
OBJECTIVE: We have previously demonstrated that LIPUS stimulates endochondral ossification with decreased expression of sclerostin. The Wnt signaling pathway was examined in vitro to further address the effect of LIPUS on endochondral ossification. MATERIALS AND METHODS: ATDC5 cells were plated at an initial density of 6 × 10 cells/well in a 6-multiwell plate and cultured in the presence of 5% FBS plus ITS. The bottom of the culture plate was treated every day with LIPUS for 20 minutes...
July 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28616217/is-chronic-kidney-disease-mineral-and-bone-disorder-associated-with-the-presence-of-endothelial-progenitor-cells-with-a-calcifying-phenotype
#3
Giuseppe Cianciolo, Irene Capelli, Maria Cappuccilli, Anna Scrivo, Chiara Donadei, Antonio Marchetti, Paola Rucci, Gaetano La Manna
Background: Chronic kidney disease-mineral and bone disorder (CKD-MBD) has been implicated in vascular calcification pathogenesis. CKD-MBD results in alterations in the number and function of circulating endothelial progenitor cells (EPCs), physiological regulators of angiogenesis and vessel repair, commonly defined as proangiogenic progenitor cells (PACs) by the antigen pattern CD34+CD133+KDR+CD45- and putative EPCs by the pattern CD34+CD133-KDR+CD45-. These cells might acquire a calcifying phenotype in CKD-MBD, expressing mineralization biomarkers...
June 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28607103/dynamin-related-protein-1-inhibition-attenuates-cardiovascular-calcification-in-the-presence-of-oxidative-stress
#4
Maximillian Rogers, Natalia Maldonado-Martinez, Joshua D Hutcheson, Claudia Goettsch, Shinji Goto, Iwao Yamada, Tyler Faits, Hiromi Sesaki, Masanori Aikawa, Elena Aikawa
Rationale: Mitochondrial changes occur during cell differentiation and cardiovascular disease. Dynamin-related protein 1 (DRP1) is a key regulator of mitochondrial fission. We hypothesized that DRP1 plays a role in cardiovascular calcification, a process involving cell differentiation and a major clinical problem with high unmet needs. Objective: To examine the effects of osteogenic promoting conditions on DRP1, and whether DRP1 inhibition alters the development of cardiovascular calcification. Methods and Results: DRP1 was enriched in calcified regions of human carotid arteries, examined by immunohistochemistry...
June 12, 2017: Circulation Research
https://www.readbyqxmd.com/read/28592560/ectopic-calcification-in-pseudoxanthoma-elasticum-responds-to-inhibition-of-tissue-nonspecific-alkaline-phosphatase
#5
Shira G Ziegler, Carlos R Ferreira, Elena Gallo MacFarlane, Ryan C Riddle, Ryan E Tomlinson, Emily Y Chew, Ludovic Martin, Chen-Ting Ma, Eduard Sergienko, Anthony B Pinkerton, José Luis Millán, William A Gahl, Harry C Dietz
Biallelic mutations in ABCC6 cause pseudoxanthoma elasticum (PXE), a disease characterized by calcification in the skin, eyes, and blood vessels. The function of ATP-binding cassette C6 (ABCC6) and the pathogenesis of PXE remain unclear. We used mouse models and patient fibroblasts to demonstrate genetic interaction and shared biochemical and cellular mechanisms underlying ectopic calcification in PXE and related disorders caused by defined perturbations in extracellular adenosine 5'-triphosphate catabolism...
June 7, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28589644/endothelial-to-mesenchymal-transformation-is-induced-by-altered-extracellular-matrix-in-aortic-valve-endothelial-cells
#6
Sudip Dahal, Peter Huang, Bruce T Murray, Gretchen J Mahler
Alterations in shear stress, mechanical deformation, extracellular matrix (ECM) composition and exposure to inflammatory conditions are known to cause endothelial to mesenchymal transformation (EndMT). This change in endothelial phenotype has only recently been linked to adult pathologies such as cancer progression, organ fibrosis, and calcific aortic valve disease; and its function in adult physiology, especially in response to tissue mechanics, has not been rigorously investigated. EndMT is a response to mechanical and biochemical signals that results in the remodeling of underlying tissues...
June 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28587566/buddy-needle-technique-to-facilitate-retrograde-puncture-of-heavily-calcified-tibial-vessels
#7
Ederi Mikelarena, August Ysa, Marta Lobato, Amaia Arruabarrena, Matthew Metcalfe, Juan L Fonseca
PURPOSE: To describe a technical trick to overcome a prior failed retrograde puncture of the tibial vessels secondary to arterial calcification. TECHNIQUE: Following a prior failed retrograde puncture attempt, the needle is left in place next to the artery. The tip of the needle is then moved toward the artery as a lever so that the artery is fixed between the needle, the skin, and the surrounding tissues. With the artery fixed, a standard puncture procedure is performed...
June 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28586348/primary-multidrug-resistant-tuberculosis-versus-drug-sensitive-tuberculosis-in-non-hiv-infected-patients-comparisons-of-ct-findings
#8
Duo Li, Wei He, Budong Chen, Pingxin Lv
BACKGROUND: Multidrug-resistant tuberculosis has emerged as a global threat. The aim of this work was to compare the CT findings of primary multidrug-resistant tuberculosis and drug-sensitive tuberculosis in non-AIDS adults. MATERIAL AND METHODS: From January 2012 to February 2016, 89 patients with primary multidrug-resistant tuberculosis were retrospectively reviewed, and 89 consecutive drug sensitive TB patients with no history of anti-tuberculous chemotherapy from January 2014 to November 2014 were enrolled as control group...
2017: PloS One
https://www.readbyqxmd.com/read/28579288/movat-pentachrom-stain-reveals-unexpected-high-osteogenesis-rate-in-aortic-valves
#9
Claudia Dittfeld, Michael Haase, Maria Feilmeier, Anett Jannasch, Petra Büttner, Katrin Plötze, Thomas Waldow, Sems-Malte Tugtekin
BACKGROUND AND AIM OF THE STUDY: Aortic valve (AV) stenosis is the most common valvular heart disease with an incidence of 3% for people ≥ 65years in the industrialized world with indication for a surgical or transcatheter valve replacement. Researchers suppose osteogenic processes as key mechanisms in calcific aortic valve stenosis. Recently, Torre et al. published impressive histological analyses and detected osseous and/or chondromatous metaplasia in 15.6% of 6685 native calcified aortic valves...
June 1, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28567346/surgery-for-calcifying-tendinitis-of-the-shoulder-a-systematic-review
#10
Freek U Verstraelen, Eric Fievez, Loes Janssen, Wim Morrenhof
AIM: To systematically search literature and determine a preferable surgical procedure in patients with failed conservative treatment of calcifying tendinitis of the shoulder. METHODS: The electronic online databases MEDLINE (through PubMed), EMBASE (through OVID), CINAHL (through EB- SCO), Web of Science and Cochrane Central Register of Controlled Trials were systematically searched in May 2016. Eligible for inclusion were all available studies with level II and level III evidence (LoE)...
May 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28567149/comparison-of-meniscal-cell-mediated-and-chondrocyte-mediated-calcification
#11
Alex J Kiraly, Andrea Roberts, Michael Cox, David Mauerhan, Edward Hanley, Yubo Sun
BACKGROUND: Chondrocytes have been traditionally thought to be responsible for calcium crystal deposits within osteoarthritic knees. Increasing recent experimental evidence suggests that menisci may also play a role. However, the calcifying potential of chondrocytes and meniscal cells derived from same OA patients, and the genes associated with meniscal calcification have never been fully examined. OBJECTIVE: Examine and compare the calcifying potential of articular chondrocytes and meniscal cells derived from same OA patients and identify the calcium crystal type(s) and selected gene expression in OA menisci...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28567092/additive-role-of-coronary-magnetic-resonance-angiography-for-the-evaluation-of-coronary-artery-disease
#12
Min Jeong Kim, Yeonyee E Yoon, Jin Joo Park, Yeo Koon Kim, Eun Ju Chun, Sang Il Choi, Goo-Young Cho
Coronary magnetic resonance angiography (CMRA) allows a noninvasive assessment of the coronary anatomy without exposing the patients to radiation. It is also superior to coronary computed tomography angiography (CCTA) for the evaluation of luminal narrowing in heavily calcified coronary segments. We report a case with triple-vessel disease, but it could not be accurately assessed by CCTA because of calcification and lack of a significant perfusion defect or myocardial scarring on cardiac magnetic resonance imaging (MRI)...
May 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28562422/serum-calcification-propensity-is-associated-with-renal-tissue-oxygenation-and-resistive-index-in-patients-with-arterial-hypertension-or-chronic-kidney-disease
#13
Menno Pruijm, Yimin Lu, Fatma Megdiche, Maciej Piskunowicz, Bastien Milani, Matthias Stuber, Matthias Bachtler, Bruno Vogt, Michel Burnier, Andreas Pasch
BACKGROUND: Arterial calcifications increase arterial stiffness and are associated with a faster decline of kidney function in patients with arterial hypertension (AH) and/or chronic kidney disease (CKD). Yet the underlying mechanisms linking arterial calcifications, vascular stiffness and renal function decline are incompletely understood. A novel in-vitro blood test evaluates the propensity of patient's serum to prevent the formation of calcifications by measuring the maturation time of calciprotein particles (CPP) [transformation time of amorphous calcium phosphate-containing primary CPP to crystalline hydroxyapatite-containing secondary CPP (T50)]...
May 29, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28559171/anatomical-and-technical-predictors-of-perioperative-clinical-outcomes-after-carotid-artery-stenting
#14
Ali F AbuRahma, Trevor DerDerian, Nizar Hariri, Elliot Adams, Joseph AbuRahma, L Scott Dean, Aravinda Nanjundappa, Patrick A Stone
BACKGROUND: A few other studies have reported the effects of anatomical and technical factors on clinical outcomes of carotid artery stenting (CAS). This study analyzed the effect of these factors on perioperative stroke/myocardial infarction/death after CAS. METHODS: This was a retrospective analysis of prospectively collected data of 409 of 456 patients who underwent CAS during the study period. A logistic regression analysis was used to determine the effects of anatomical and technical factors on perioperative stroke, death, and myocardial infarction (major adverse events [MAEs])...
May 27, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28555644/coral-calcification-in-a-changing-world-and-the-interactive-dynamics-of-ph-and-dic-upregulation
#15
Malcolm T McCulloch, Juan Pablo D'Olivo, James Falter, Michael Holcomb, Julie A Trotter
Coral calcification is dependent on the mutualistic partnership between endosymbiotic zooxanthellae and the coral host. Here, using newly developed geochemical proxies (δ(11)B and B/Ca), we show that Porites corals from natural reef environments exhibit a close (r(2) ∼0.9) antithetic relationship between dissolved inorganic carbon (DIC) and pH of the corals' calcifying fluid (cf). The highest DICcf (∼ × 3.2 seawater) is found during summer, consistent with thermal/light enhancement of metabolically (zooxanthellae) derived carbon, while the highest pHcf (∼8...
May 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/28553851/morphometric-parameters-of-cardiac-implantable-electronic-device-cied-pocket-walls-observed-on-device-replacement
#16
Roman Steckiewicz, Elżbieta Barbara Świętoń, Agnieszka Kołodzińska, Magdalena Bogdańska, Łukasz Fus, Przemysław Solarz
BACKGROUND: The final stage of a conventional de-novo cardiac implantable electronic device (CIED) implantation procedure with transvenous lead insertion involves the formation of a pocket by tissue separation superficial to the pectoralis major muscle in the right or left infraclavicular region, where the device is subsequently placed. Over time, a scar "capsule" forms around the CIED as a result of normal biological remodeling. MATERIALS AND METHODS: The purpose of this study was to analyze the structure and present the variations of CIED capsules observed during device replacement...
May 29, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28552661/30years-of-dxa-technology-innovations
#17
Claus-C Glüer
As the successor of Dual Photon Absorptiometry (DPA), Dual X-ray Absorptiometry (DXA) has seen 30years of continuous technological innovations. Implementation of measures for standardization and quality assurance made DXA a reliable and clinically useful approach. Its use in clinical multicenter drug studies in osteoporosis lead to general acceptance as the standard technique of bone densitometry. The limitations of DXA are well established. As a measure of areal bone mineral density (aBMD) it depends on bone size and is biased by overlaying soft tissue and calcified structures...
May 24, 2017: Bone
https://www.readbyqxmd.com/read/28550355/coronary-computed-tomography-angiography-using-128-slice-dual-source-computed-tomography-in-patients-with-severe-calcification
#18
Suguru Sato, Yosuke Horii, Norihiko Yoshimura, Takuya Yagi, Hidefumi Aoyama
PURPOSE: To compare coronary computed tomography angiography (CTA) and coronary angiography (CAG) with regard to luminal graphic definition of calcified segments using 128-slice dual-source computed tomography (DSCT), specifically for patients with an Agatston score >400. MATERIALS AND METHODS: Of 1148 consecutive patients who underwent coronary CTA using a 128-slice DSCT, 132 subjects had severe calcification with an Agatston score >400. Thirty-nine of the 132 patients who had undergone CAG within 3 months before or after coronary CTA were included...
May 26, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28549916/utility-of-carotid-ultrasonography-in-management-of-an-atypical-high-vascular-risk-patient-with-recurrent-calcified-cerebral-embolic-stroke
#19
John W Liang, Jesse Weinberger, Aaron Tansy
OBJECTIVE: To describe a case of recurrent calcified cerebral emboli (CCE)-related acute ischemic stroke (AIS) and the diagnostic utility of plaque morphology characterization on carotid ultrasound. BACKGROUND: CCE are a rare cause of AIS. CCE-related AIS has been previously reported only in high vascular-risk patients such as those with severe carotid stenosis, widespread atheromatous disease, or cardiac valvular disease. CCE-related AIS from a carotid origin has not been reported in patients without carotid stenosis...
May 23, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28546218/adamts5-deficiency-in-calcified-aortic-valves-is-associated-with-elevated-pro-osteogenic-activity-in-valvular-interstitial-cells
#20
Fei Li, Rui Song, Lihua Ao, T Brett Reece, Joseph C Cleveland, Nianguo Dong, David A Fullerton, Xianzhong Meng
OBJECTIVE: Extracellular matrix proteinases are implicated in the pathogenesis of calcific aortic valve disease. The ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) enzyme is secreted, matrix-associated metalloendopeptidase, capable of degrading extracellular matrix proteins, particularly matrilin 2. We sought to determine the role of the ADAMTS5/matrilin 2 axis in mediating the phenotype transition of valvular interstitial cells (VICs) associated with calcific aortic valve disease...
May 25, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
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