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https://www.readbyqxmd.com/read/29333372/ghost-cell-odontogenic-carcinoma-on-right-mandible-and-its-respective-surgical-reconstruction-a-case-report
#1
Sang Yoon Park, Joonhyoung Park, Do Hyun Kwon, Jae Ho Jeon, Soung Min Kim, Hoon Myoung, Jong Ho Lee
Calcifying cystic odontogenic tumor (CCOT) is defined as an odontogenic cyst-like benign neoplasm that characteristically contains several ghost cells, ameloblastoma-like epithelium, and occasional calcification. Ghost cell odontogenic carcinoma (GCOC), a malignant form of CCOT, is an exceptionally rare malignant tumor. In this report, we present a case of a 53-year-old man whose chief complaint was a solitary mass on the right mandible area. The mass was completely removed through an extraoral surgical approach and reconstructive surgery was performed in two phases...
December 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29332915/calcified-amorphous-tumor-induced-acute-cerebral-infarction
#2
Yoshihiro Aizawa, Toshiko Nakai, Yuki Saito, Koyuru Monno, Tomoyuki Morikawa, Rikitake Kogawa, Takumi Hatta, Takehiro Tamaki, Mahoto Kato, Munehito Arimoto, Shunji Osaka, Keishin Sunagawa, Xiao Yan Tang, Masashi Tanaka, Hiroyuki Hao, Atsushi Hirayama
We report the case of a 38-year-old woman who was admitted for acute cerebral infarction linked to a cardiac calcified amorphous tumor (CAT) and related mitral annular calcification (MAC). The cardiac mass was removed, and mitral valve replacement surgery was performed. Pathological examination revealed an amorphous accumulation of degenerating material within both lesions, indicating that build-up of calcium along the mitral annulus and subsequent rupture of the fibrotic tissue may be involved in the initiation and progression of CAT...
January 15, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29326493/renal-mitochondria-can-withstand-hypoxic-ischemic-injury-secondary-to-renal-failure-in-uremic-rats-pretreated-with-sodium-thiosulfate
#3
Dhivya Mohan, Eswari Dhivya Balasubramanian, Sriram Ravindran, Gino A Kurian
BACKGROUND: Sodium thiosulfate (STS) is a potent drug used to treat calcific uremic arteriopathy in dialysis patients and its mode of action is envisaged by calcium chelation and antioxidant potential. STS's action on mitochondrial dysfunction, one of the major players in the pathology of vascular calcification is yet to be explored. METHODS: Adenine (0.75%, 28 days)-treated vascular calcified rat kidney was used to isolate mitochondria, where the animal was administered with or without STS for 28 days...
July 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29325369/-cd137-signaling-promotes-the-formation-of-plaque-calcification-via-inhibiting-the-fusion-of-autophagy-and-lysosomal-in-apo-e-mice
#4
X Y Li, R Chen, W Zhong, B Li, C Shao, Z Q Wang, J C Yan
Objective: To investigate whether CD137 signaling promoted the formation of atherosclerotic plaque calcification by inhibiting the fusion of autophagosome and lysosome. Methods: (1) In vivo, CD137 agonist antibody and anti-CD137 antibody were used to stimulate and inhibit the CD137 signaling, respectively. Fifteen Apo E(-/-) mice were randomly divided into three groups: control group (intraperitoneal injection of IgG2b 200 µg) , CD137 agonist group (intraperitoneal injection of CD137 agonist antibody 200 µg) , anti-CD137 group (pretreatment with 200 µg anti-CD137 antibody for 24 hours, then injection of CD137 agonist antibody) ...
December 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29321296/substrate-growth-dynamics-and-biomineralization-of-an-ediacaran-encrusting-poriferan
#5
Rachel Wood, Amelia Penny
The ability to encrust in order to secure and maintain growth on a substrate is a key competitive innovation in benthic metazoans. Here we describe the substrate growth dynamics, mode of biomineralization and possible affinity of Namapoikia rietoogensis, a large (up to 1 m), robustly skeletal, and modular Ediacaran metazoan which encrusted the walls of synsedimentary fissures within microbial-metazoan reefs. Namapoikia formed laminar or domal morphologies with an internal structure of open tubules and transverse elements, and had a very plastic, non-deterministic growth form which could encrust both fully lithified surfaces as well as living microbial substrates, the latter via modified skeletal holdfasts...
January 10, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29318407/optical-frequency-domain-imaging-findings-to-predict-good-stent-expansion-after-rotational-atherectomy-for-severely-calcified-coronary-lesions
#6
Norihiro Kobayashi, Yoshiaki Ito, Masahiro Yamawaki, Motoharu Araki, Tsuyoshi Sakai, Yasunari Sakamoto, Shinsuke Mori, Masakazu Tsutsumi, Masahiro Nauchi, Yohsuke Honda, Takahiro Tokuda, Kenji Makino, Shigemitsu Shirai, Keisuke Hirano
We aimed to evaluate the optical frequency-domain imaging (OFDI) findings after rotational atherectomy (RA) that predict good stent expansion for severely calcified coronary lesions. Fifty consecutive calcified lesions were subjected to RA under OFDI guidance. We performed OFDI just after RA and stenting. We measured the morphology of calcium after RA, and assessed how these factors influence stent expansion. The stent expansion index was defined as the minimum stent area divided by the average of the proximal and distal reference lumen areas...
January 9, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29315312/taking-the-metabolic-pulse-of-the-world-s-coral-reefs
#7
Tyler Cyronak, Andreas J Andersson, Chris Langdon, Rebecca Albright, Nicholas R Bates, Ken Caldeira, Renee Carlton, Jorge E Corredor, Rob B Dunbar, Ian Enochs, Jonathan Erez, Bradley D Eyre, Jean-Pierre Gattuso, Dwight Gledhill, Hajime Kayanne, David I Kline, David A Koweek, Coulson Lantz, Boaz Lazar, Derek Manzello, Ashly McMahon, Melissa Meléndez, Heather N Page, Isaac R Santos, Kai G Schulz, Emily Shaw, Jacob Silverman, Atsushi Suzuki, Lida Teneva, Atsushi Watanabe, Shoji Yamamoto
Worldwide, coral reef ecosystems are experiencing increasing pressure from a variety of anthropogenic perturbations including ocean warming and acidification, increased sedimentation, eutrophication, and overfishing, which could shift reefs to a condition of net calcium carbonate (CaCO3) dissolution and erosion. Herein, we determine the net calcification potential and the relative balance of net organic carbon metabolism (net community production; NCP) and net inorganic carbon metabolism (net community calcification; NCC) within 23 coral reef locations across the globe...
2018: PloS One
https://www.readbyqxmd.com/read/29305348/computed-tomographic-coronary-angiography-derived-plaque-characteristics-predict-major-adverse-cardiovascular-events-a-systematic-review-and-meta-analysis
#8
Nitesh Nerlekar, Francis J Ha, Caitlin Cheshire, Hashrul Rashid, James D Cameron, Dennis T Wong, Sujith Seneviratne, Adam J Brown
BACKGROUND: Computed tomographic coronary angiography is a noninvasive imaging modality that permits identification and characterization of coronary plaques. Despite consensus statements supporting routine reporting of computed tomographic coronary angiography plaque characteristics, there remains uncertainty whether these data convey prognostic information. We performed a systematic review and meta-analysis assessing the strength of association between computed tomographic coronary angiography-derived plaque characterization and major adverse cardiovascular events (MACE)...
January 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29304096/exogenous-bmp7-in-aortae-of-rats-with-chronic-uremia-ameliorates-expression-of-profibrotic-genes-but-does-not-reverse-established-vascular-calcification
#9
Eva Gravesen, Maria Lerche Mace, Anders Nordholm, Jacob Hofman-Bang, Keith Hruska, Carsten Haagen Nielsen, Andreas Kjær, Klaus Olgaard, Ewa Lewin
Hyperphosphatemia and vascular calcification are frequent complications of chronic renal failure and bone morphogenetic protein 7 (BMP7) has been shown to protect against development of vascular calcification in uremia. The present investigation examined the potential reversibility of established uremic vascular calcification by treatment of uremic rats with BMP7. A control model of isogenic transplantation of a calcified aorta from uremic rats into healthy littermates examined whether normalization of the uremic environment reversed vascular calcification...
2018: PloS One
https://www.readbyqxmd.com/read/29302564/caseous-mitral-annular-calcification-mimicking-a-lung-tumor-on-chest-x-ray
#10
Philip Dingli, Herbert Felice, Adrian Mizzi, Stephen Montefort
Mitral annular calcification (MAC) is a common condition of the mitral valve apparatus. A case involving caseous calcification, a rare variant of MAC is presented. This variant which has a benign course can present as an intracardiac mass and needs to be differentiated from more sinister causes of calcified cardiac masses such as tumor, abscess, and infective vegetation. Often, this requires multimodality imaging with echocardiography, computed tomography, and magnetic resonance imaging. Features of caseous calcification of the mitral valve on these imaging modalities are reviewed as the associations and clinical features...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29299089/hamartoma-of-the-spleen-splenoma-with-calcifications-in-a-child-with-beta-thalassemia-a-case-report
#11
Dario Giambelluca, Dario Picone, Giuseppe Lo Re, Salvatore Pappalardo, Placido Romeo
Splenic hamartoma (or splenoma) is a rare, benign, vascular tumor, often incidentally found at imaging, surgery or autopsy. Albeit usually asymptomatic and rare in children, when it occurs in the pediatric population it is more commonly symptomatic. We report a case of a 15-year-old girl with iron-deficiency anemia and beta-thalassemia, who had a large (10 × 8 × 7 cm) splenic lesion with calcifications, incidentally found during follow-up for splenomegaly and histologically characterized as hamartoma with calcified areas...
May 2017: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/29298138/the-ecology-biogeochemistry-and-optical-properties-of-coccolithophores
#12
William M Balch
Coccolithophores are major contributors to phytoplankton communities and ocean biogeochemistry and are strong modulators of the optical field in the sea. New discoveries are changing paradigms about these calcifiers. A new role for silicon in coccolithophore calcification is coupling carbonate and silicon cycles. Phosphorus and iron play key roles in regulating coccolithophore growth. Comparing molecular phylogenies with coccolith morphometrics is forcing the reconciliation of biological and geological observations...
January 3, 2018: Annual Review of Marine Science
https://www.readbyqxmd.com/read/29296066/multimodality-imaging-assessment-of-a-caseous-calcification-of-the-mitral-valve-annulus
#13
Imen Hamdi, Chadia Chourabi, Younes Arous, Mehdi Ghommidh, Khalil Houissa, Abdeddayem Haggui, Nadhem Hajlaoui, Dhaker Lahidheb, Nejmeddine Ben Abdallah, Wafa Fehri, Habib Haouala
Caseous calcification of the mitral annulus (CCMA) is a rare echocardiographic finding. It is commonly misdiagnosed as an abscess, tumor or infective vegetation on the mitral valve. Since it is a benign process, differentiating it from malignant intra-cardiac mass is primordial to avoid unnecessary surgery. Various imaging modalities can be complimentary for definitive diagnosis. We present a case of CCMA in a 71-year-old female patient. Her medical history revealed hypertension, diabetes mellitus, hyperlipidaemia and coronary artery disease...
January 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29290085/extra-renal-transplanted-kidney-stone-case-presentation-and-literature-review
#14
Abbas Basiri, Mohammad Nadjafi Semnani, Hamed Mohseni Rad
Soft tissue calcification is common in uremic patients. Wound calcification or ossification is not so prevalent except in specific conditions like inflammation and ischemia or wound tension. We present a 40-year-old transplanted patient, not only perirenal ossification but also with multiple perirenal stones. The presentation was severe pain on the site of transplantation. Pre-op CT scan revealed perirenal calcified mass. Intraoperative finding was verythick tissue accompanied with a lot of stones around the transplanted kidney...
December 30, 2017: Urology Journal
https://www.readbyqxmd.com/read/29288724/serum-fetuin-a-levels-in-patients-with-bilateral-basal-ganglia-calcification
#15
Bekir Enes Demiryurek, Asli Aksoy Gundogdu
BACKGROUND AND PURPOSE: The idiopathic basal ganglia calcification (Fahr syndrome) may occur due to senility. Fetuin-A is a negative acute phase reactant which inhibits calcium-phosphorus precipitation and vascular calcification. In this study, we aimed to evaluate whether serum fetuin-A levels correlate with bilateral basal ganglia calcification. METHOD: Forty-five patients who had bilateral basal ganglia calcification on brain CT were selected according to the inclusion and exclusion criteria, and 45 age and gender-matched subjects without basal ganglia calcification were included for the control group...
December 27, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29287893/-tumoral-calcinoses-in-a-chronic-hemodialysis-patient-the-role-of-spect-ct-hybrid-imaging
#16
Aboubakr Matrane, Soufiane Hiroual, Mohamed Aziz Bsiss, Safa Bennani Doubli
INTRODUCTION: Tumoral calcinosis is a rare benign disease, defined by the presence of calcified deposits in periarticular tissues. It can be hereditary or secondary at chronic renal failure at the stage of dialysis. This work illustrates the contribution of single-photon emission computed tomography (SPECT/CT) in the diagnosis and management of tumoral calcinoses in a chronic hemodialysis patient, based on a clinical case. CASE REPORT: A 62-year-old patient, chronic hemodialysis since 24 years, presented a mechanical pain shoulders, knees and hips with limitation of joint mobility...
December 26, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29287860/primary-cervical-leiomyoma-a-rare-cause-of-a-posterior-neck-mass-in-a-pediatric-patient
#17
Jeremie D Oliver, C Lane Anzalone, Karthik Balakrishnan
A 13-year-old male presents for evaluation of a right-sided posterolateral neck mass, first noted four years prior to presentation; incisional biopsy two years ago suggested a benign lymph node. Recent growth and increased pain prompted referral to our tertiary care center. MR imaging revealed a densely calcified mass in the right posterior paraspinous muscles with intense enhancement with gadolinium contrast, approximately 5 cm × 2.8 cm x 4.6 cm. Incisional biopsy showed leiomyoma with extensive dystrophic calcifications...
January 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29279525/planimetry-of-the-orifice-area-in-aortic-valve-stenosis-using-phase-contrast-cardiac-magnetic-resonance-imaging
#18
Hajime Abe, Nobuo Iguchi, Yuko Utanohara, Kaori Takada, Yasuki Hen, Haruhiko Machida, Norihiko Takeda, Tetsuya Sumiyoshi
Manual planimetry is a well-established method using transesophageal echocardiography (TEE) to assess the severity of aortic stenosis (AS). TEE, however, is a less than optimal approach in patients with calcified valves. Even when using cine-cardiac magnetic resonance (CMR), it is often difficult to evaluate the true border of the aortic orifice because of jet turbulence. With phase-contrast sequences of CMR, high flow signals at the aortic orifice can be clearly visualized, even in cases with severe calcification and jet turbulence...
December 27, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29273504/fibroblast-growth-factor-21-ameliorates-vascular-calcification-by-inhibiting-osteogenic-transition-in-vitamin-d3-plus-nicotine-treated-rats
#19
Yuchen Shi, Weiwei Lu, Yuelong Hou, Kun Fu, Feng Gan, Jinghua Liu
FGF21, a special member of FGF superfamily, has been proven to have pleiotropic metabolic effects and many potential therapeutic action in various metabolic disorders. Vascular calcification (VC), a perplexing clinical issue, is a major risk factor for many cardiovascular diseases, especially for patients with some metabolic diseases. However, the role of FGF21 on VC in vivo remains unclear. Thus, in this study, we observed the effect and mechanism of FGF21 on VC induced by vitamin D3 plus nicotine (VDN) treated rats...
December 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29258711/mechanisms-of-aortic-stenosis
#20
REVIEW
Hirokuni Akahori, Takeshi Tsujino, Tohru Masuyama, Masaharu Ishihara
The pathobiology of degenerative aortic valve stenosis (AS) is complex and involves multiple features such as fibrosis, inflammation, oxidative stress, angiogenesis, hemorrhage, and osteogenic differentiation. We summarize the mechanism of valve calcification and angiogenesis which is necessary for calcifying processes. A promising therapeutic target is nuclear factor (NF)-κB which activates bone morphogenetic protein (BMP)2 via interleukin-6. BMP2 activates Wnt signaling via msh homeobox 2 causing osteogenic differentiation...
December 16, 2017: Journal of Cardiology
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