Bang Wang, Firas Kobeissy, Mojtaba Golpich, Guangzheng Cai, Xiaowei Li, Reem Abedi, William Haskins, Weihong Tan, Steven A Benner, Kevin K W Wang
Aptamers developed using in vitro Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technology are single-stranded nucleic acids 10-100 nucleotides in length. Their targets, often with specificity and high affinity, range from ions and small molecules to proteins and other biological molecules as well as larger systems, including cells, tissues, and animals. Aptamers often rival conventional antibodies with improved performance, due to aptamers' unique biophysical and biochemical properties, including small size, synthetic accessibility, facile modification, low production cost, and low immunogenicity...
March 2, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry