keyword
https://read.qxmd.com/read/38534733/in-silico-approach-to-molecular-profiling-of-the-transition-from-ovarian-epithelial-cells-to-low-grade-serous-ovarian-tumors-for-targeted-therapeutic-insights
#1
JOURNAL ARTICLE
Asim Leblebici, Ceren Sancar, Bahar Tercan, Zerrin Isik, Mehmet Emin Arayici, Ender Berat Ellidokuz, Yasemin Basbinar, Nuri Yildirim
This paper aims to elucidate the differentially coexpressed genes, their potential mechanisms, and possible drug targets in low-grade invasive serous ovarian carcinoma (LGSC) in terms of the biologic continuity of normal, borderline, and malignant LGSC. We performed a bioinformatics analysis, integrating datasets generated using the GPL570 platform from different studies from the GEO database to identify changes in this transition, gene expression, drug targets, and their relationships with tumor microenvironmental characteristics...
February 26, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38529526/the-use-of-optical-coherence-tomography-oct-and-oct-angiography-in-borderline-personality-disorder-compared-to-health-control-subjects
#2
JOURNAL ARTICLE
Bei Xu, Fangling Li, Zhejia Zhang, Qian Xiao
BACKGROUND: Optical coherence tomography (OCT) or OCT angiography (OCTA) has been investigated in few research studies of psychiatric disorders. No research has been done using OCT or OCTA in patients with borderline personality disorder (BPD). METHODS: OCTA measured foveal avascular zone (FAZ), macular vessel density (MVD), and peripapillary vessel density (PVD). OCT measured the peripapillary retinal fiber layer (RNFL) and central retinal thickness (CRT). The study utilized the Ottawa Self-Injury Inventory, Hamilton Anxiety Rating Scale (HAMA), and Global Assessment of Functioning (GAF) to assess the symptom characteristics of individuals with BPD...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38526405/prodromal-or-factitious-psychosis-a-cautionary-tale-in-the-era-of-increasing-social-media-use-by-vulnerable-individuals
#3
JOURNAL ARTICLE
Leo Bastiaens, Stephanie Cristofano-Casella, Jesse Bastiaens
Research on the prodromal phase of schizophrenia has been ongoing for several decades and, more recently, findings from this research are being incorporated into everyday psychiatric practice, such as the use of interviews to evaluate prodromal symptomatology. This evolution is happening in the midst of an explosion of social media use by teenagers and young adults, increasing the exposure of youth to portrayals of psychiatric experiences. For example, reports from around the world of "TIK-TOK tics" emphasize the role of social media in the "creation" of psychiatric symptoms...
March 1, 2024: Journal of Psychiatric Practice
https://read.qxmd.com/read/38524666/an-attenuated-adult-case-of-aadc-deficiency-demonstrated-by-protein-characterization
#4
Giovanni Bisello, Christiaan G J Saris, Rossella Franchini, Marcel M Verbeek, Michel A A P Willemsen, Massimiliano Perduca, Mariarita Bertoldi
A case of an adult with borderline AADC deficiency symptoms is presented here. Genetic analysis revealed that the patient carries two AADC variants (NM_000790.3: c.1040G > A and c.679G > C) in compound heterozygosis, resulting in p.Arg347Gln and p.Glu227Gln amino acid alterations. While p.Arg347Gln is a known pathogenic variant, p.Glu227Gln is unknown. Combining clinical features to bioinformatic and molecular characterization of the AADC protein population of the patient (p.Arg347Gln/p...
June 2024: Molecular Genetics and Metabolism Reports
https://read.qxmd.com/read/38523413/a-comprehensive-analysis-of-age-of-onset-and-cumulative-incidence-of-mental-disorders-a-danish-register-study
#5
JOURNAL ARTICLE
Christoffer Beck, Carsten Bøcker Pedersen, Oleguer Plana-Ripoll, Søren Dalsgaard, Jean-Christophe Philippe Debost, Thomas Munk Laursen, Katherine Louise Musliner, Preben Bo Mortensen, Marianne Giørtz Pedersen, Liselotte Vogdrup Petersen, Zeynep Yilmaz, John McGrath, Esben Agerbo
BACKGROUND: The age of onset (AOO), incidence and cumulative incidence of mental disorders are critical epidemiological measures, providing essential insights into the development and course of these disorders across the lifespan. This study aims to provide up-to-date estimates of the AOO, age-specific incidence, and cumulative incidence for a comprehensive range of mental disorders using data from Danish registers. METHODS: We conducted a follow-up study encompassing all Danish residents from January 1, 2004, to December 31, 2021, totaling 91,613,465 person-years...
March 24, 2024: Acta Psychiatrica Scandinavica
https://read.qxmd.com/read/38523025/-effectiveness-of-psychotherapy-on-dissociative-symptoms-in-adult-populations-a-prisma-systematic-review
#6
JOURNAL ARTICLE
Camille Aujoulat, Alexis Vancappel, Géraldine Tapia
INTRODUCTION: Dissociation is a psychological process in reaction to threat which can be found in many psychiatric conditions. Dissociative symptoms can become very disabling, whether in daily life or in care. Nevertheless, few studies seem to have examined the efficacy of psychotherapy on the latter and its relevance as a therapeutic target. METHOD: A systematic review of the literature (PRISMA) on the efficacy of psychotherapy on dissociative symptoms in adults with mental disorders was conducted...
March 23, 2024: L'Encéphale
https://read.qxmd.com/read/38522259/the-course-of-borderline-personality-disorder-from-adolescence-to-early-adulthood-a-5-year-follow-up-study
#7
JOURNAL ARTICLE
Mie Sedoc Jørgensen, Lise Møller, Sune Bo, Mickey Kongerslev, Lene Halling Hastrup, Andrew Chanen, Ole Jakob Storebø, Stig Poulsen, Emma Beck, Erik Simonsen
BACKGROUND: Studies of the medium- to long-term clinical and functional course for treatment-seeking adolescents with borderline personality disorder (BPD) are lacking. This study aims to outline the psychopathological and functional status of participants, five years after being diagnosed with BPD during adolescence. METHODS: Participants were originally enrolled in a randomized clinical trial that compared mentalization-based group treatment with treatment as usual for adolescents with BPD...
March 21, 2024: Comprehensive Psychiatry
https://read.qxmd.com/read/38509797/personality-attributions-in-the-context-of-stalking-of-ex-intimates-or-others-a-victim-s-perspective
#8
JOURNAL ARTICLE
Lily Truss, Melissa S de Roos
Stalking perpetrators may suffer from maladaptive personality traits, particularly if they stalk in the context of an (ex-)intimate relationship. To date, no study has examined how different personality attributions may relate to stalker motivation, or the behaviors they engage in, and how this differs across victim-perpetrator relationships. Further, the perspective of the victim is often not taken into consideration, even though most stalking victims know their stalker intimately and a majority are stalked by a former or current partner...
March 21, 2024: International Journal of Offender Therapy and Comparative Criminology
https://read.qxmd.com/read/38508200/assessing-measurement-consistency-a-study-of-the-bpfsc-invariance-across-age-and-sex-in-romanian-adolescents
#9
JOURNAL ARTICLE
Samuel Bud, Aurora Szentágotai-Tătar
The Borderline Personality Feature Scale for Children (BPFSC) is a widely used instrument and currently the only dimensional measure to investigate Borderline Personality features in children and adolescents. The present study aimed to investigate the factor structure and measurement invariance across age and sex in a community sample of 634 adolescents (mean age = 16.72, standard deviation = 1.31). To test for measurement invariance, we conducted multi-group confirmatory factor analysis (MG-CFA). Analysis showed residual invariance across age and sex...
March 20, 2024: Psychological Reports
https://read.qxmd.com/read/38502144/bpd-compass-using-a-dimensional-model-of-psychopathology-to-treat-co-occurring-borderline-personality-disorder-and-posttraumatic-stress-symptoms
#10
JOURNAL ARTICLE
Caitlyn O Hood, Matthew W Southward, Christal L Badour, Shannon Sauer-Zavala
BPD Compass is a transdiagnostic psychotherapy that includes cognitive, behavioral, and mindfulness skills targeting the personality dimensions of negative affectivity, disinhibition, and antagonism. Given considerable symptom comorbidity and overlap in etiology between borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD), this study investigated whether BPD Compass holds promise as an integrated approach to simultaneously treating co-occurring BPD features and PTSD symptoms. Participants included 84 trauma-exposed adults who participated in a two-phase clinical trial (Phase 1: randomized controlled trial of BPD Compass vs...
March 19, 2024: Journal of Traumatic Stress
https://read.qxmd.com/read/38500169/borderline-personality-disorder-and-sexuality-causes-and-consequences-of-dissociative-symptoms
#11
JOURNAL ARTICLE
Rose Gholami Mazinan, Christina Dudek, Hannah Warkentin, Maja Finkenstaedt, Johanna Schröder, Richard Musil, Leonhard Kratzer, Johannes Fuss, Sarah V Biedermann
BACKGROUND: Sexual risk behavior in patients diagnosed with borderline personality disorder (BPD) is supposed to be associated with traumatic experiences and dissociative symptoms. Nevertheless, scientific research thereon is scarce which might be due to the high prevalence of sexual trauma and fear of overwhelming patients with explicit sexual content. METHODS: We investigated a clinical sample of patients diagnosed with BPD (n = 114) and compared them to a sample of matched healthy controls (HC) (n = 114) concerning the dissociative symptoms derealization, depersonalization, and conversion in sexual situations...
March 19, 2024: Borderline Personality Disorder and Emotion Dysregulation
https://read.qxmd.com/read/38500080/experts-perspectives-on-the-impact-of-visual-impairment-and-comorbid-mental-disorders-on-functioning-in-essential-life-domains
#12
JOURNAL ARTICLE
Marjolein LA Onnink, Lisanne Ba Teunissen, Peter Fj Verstraten, Ruth Ma van Nispen, Hilde Pa van der Aa
BACKGROUND: Visual impairment (VI) with comorbid mental disorders (MDs) are expected to have a major impact on people's daily functioning, for which tailored support is needed. However, this has been barely investigated. Therefore, this study aimed to (1) determine the impact of VI and comorbid MDs on functioning in essential life domains, (2) gain insight into best-practices that are currently used to support this target group, and (3) determine strategies to optimize care in the future...
March 18, 2024: BMC Psychiatry
https://read.qxmd.com/read/38497592/dissociative-experiences-borderline-personality-disorder-features-and-childhood-trauma-generating-hypotheses-from-data-driven-network-analysis-in-an-international-sample
#13
JOURNAL ARTICLE
Anna Schulze, Natasha Hughes, Stefanie Lis, Annegret Krause-Utz
Dissociation is a multifaceted phenomenon that occurs in various mental disorders, including borderline personality disorder (BPD), but also in non-clinical populations. Severity of childhood trauma (abuse, neglect) plays an important role in the development of dissociation and BPD. However, the complex interplay of different dissociative symptoms, BPD features, and self-reported childhood trauma experiences is not yet fully understood. Graph-theoretical network analysis can help to better understand such multivariate interrelations...
March 18, 2024: Journal of Trauma & Dissociation
https://read.qxmd.com/read/38495902/twenty-years-of-research-on-borderline-personality-disorder-a-scientometric-analysis-of-hotspots-bursts-and-research-trends
#14
REVIEW
Yuanli Liu, Chaomei Chen, Ying Zhou, Na Zhang, Shen Liu
Borderline personality disorder (BPD), a complex and severe psychiatric disorder, has become a topic of considerable interest to current researchers due to its high incidence and severity of consequences. There is a lack of a bibliometric analysis to visualize the history and developmental trends of researches in BPD. We retrieved 7919 relevant publications on the Web of Science platform and analyzed them using software CiteSpace (6.2.R4). The results showed that there has been an overall upward trend in research interest in BPD over the past two decades...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38492542/amygdala-functional-connectivity-in-borderline-personality-disorder
#15
JOURNAL ARTICLE
Laila Noor, Jonas Hoffmann, Tina Meller, Christian Gaser, Igor Nenadić
Borderline personality disorder (BPD) is characterised by structural and functional brain alterations. Yet, there is little data on functional connectivity (FC) across different levels of brain networks and parameters. In this study, we applied a multi-level approach to analyse abnormal functional connectivity. We analysed resting-state functional magnetic resonance imaging (fMRI) data sets of 69 subjects: 17 female BPD patients and 51 age-matched psychiatrically healthy female controls. fMRI was analysed using CONN toolbox including: a) seed-based FC analysis of amygdala connectivity, b) independent component analysis (ICA) based network analysis of intra- and inter-network FC of selected resting-state networks (DMN, SN, FPN), as well as c) graph-theory based measures of network-level characteristics...
March 11, 2024: Psychiatry Research. Neuroimaging
https://read.qxmd.com/read/38492474/fertility-potential-and-safety-assessment-of-residual-ovarian-cortex-in-young-women-diagnosed-with-epithelial-borderline-and-early-stage-malignant-ovarian-tumors
#16
JOURNAL ARTICLE
L Cacciottola, A Camboni, E Gatti, E Marbaix, M Vignali, J Donnez, M M Dolmans
OBJECTIVE: To establish the safety and quality of ovarian cortex surrounding epithelial ovarian tumors in women eligible for fertility-sparing surgery by identifying occult malignant lesions and characterizing the ovarian follicle pool. METHODS: Multicentric retrospective study of 48 subjects (15-45 years), diagnosed with borderline ovarian tumors (BOTs) or early-stage epithelial ovarian cancers (EOCs) and eligible for fertility-sparing surgery. Histological samples of ovarian cortex surrounding tumors were analyzed to characterize the follicle pool, find any occult malignant lesion using tumor-specific markers (cytokeratin 7 and mucin 1), and quantify tumor-infiltrating lymphocytes (TILs) by CD3 and tumor associated macrophages (TAMs) by CD68...
March 15, 2024: Gynecologic Oncology
https://read.qxmd.com/read/38489261/good-psychiatric-management-for-borderline-personality-disorder-a-qualitative-study-of-its-implementation-in-a-supported-employment-team
#17
JOURNAL ARTICLE
Noëllie Dunand, Philippe Golay, Charles Bonsack, Danièle Spagnoli, Valentino Pomini
INTRODUCTION: People with borderline personality disorder have difficulties with work. The Individual Placement and Support model has shown its worldwide effectiveness in terms of vocational rehabilitation for individuals with psychiatric disorders. However, only a few recent studies have explored its results for people with personality disorders, and the findings were mitigated. Additionally, Individual Placement and Support job coaches reported difficulties in supporting this population...
2024: PloS One
https://read.qxmd.com/read/38482732/borderline-personality-disorder-and-stigma-lived-experience-perspectives-on-helpful-and-hurtful-language
#18
JOURNAL ARTICLE
Charlotte C van Schie, Kate Lewis, Karlen R Barr, Mahlie Jewell, Natalie Malcolmson, Michelle L Townsend, Brin F S Grenyer
Borderline personality disorder (BPD) is a severe mental health disorder that is subject to significant stigmatisation. With language being a key reinforcer of stigma, this co-produced study aims to explore the language use regarding BPD and its effect on those with BPD and carers. Recommendations to reduce stigmatisation are provided for both clinicians and researchers. Participants with BPD (consumer n = 33) and those supporting someone with BPD (carer n = 30) discussed their experience of hurtful and helpful language...
March 14, 2024: Personality and Mental Health
https://read.qxmd.com/read/38477064/decreased-oxytocin-levels-related-to-social-cognition-impairment-in-borderline-personality-disorder
#19
JOURNAL ARTICLE
Alejandra Galvez-Merlin, José M López-Villatoro, Pilar de la Higuera-González, Alejandro de la Torre-Luque, Karina McDowell, Marina Díaz-Marsá, Juan C Leza, José L Carrasco
INTRODUCTION: Dysfunctions in the oxytocin system have been reported in patients with borderline personality disorder (BPD). Deficits could be related to interpersonal hypersensitivity, which has been previously associated with failures in social cognition (SC) in this disorder, especially in Theory of Mind (ToM) skills. The aim of this work is to study the links between the oxytocin system and SC impairments in patients with BPD. METHOD: Plasma oxytocin levels (OXT) and protein expression of oxytocin receptors in blood mononuclear cells (OXTR) were examined in 33 patients with a diagnosis of BPD (age: M 28...
March 13, 2024: Acta Psychiatrica Scandinavica
https://read.qxmd.com/read/38476088/temperamental-underpinnings-of-borderline-personality-disorder-and-its-facets
#20
JOURNAL ARTICLE
Piotr P Brud, Jan Cieciuch
Temperament is claimed to be the basis for personality; therefore, discovering the temperamental underpinnings of borderline personality disorder and its facets is crucial for understanding this personality disorder. In this article, we explore these underpinnings by using a new model of temperament, based on the Regulative Theory of Temperament, the Big Two of temperament, and the Circumplex of Personality Metatraits. Two studies were conducted on adults-the first was in a general population sample (N = 315) and the second was in a clinical sample (N = 113) in people with a diagnosis of borderline personality disorder...
March 13, 2024: Personality and Mental Health
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