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https://www.readbyqxmd.com/read/28527968/rapid-immunohistochemistry-with-thyroid-transcription-factor-1-for-pulmonary-adenocarcinoma
#1
Hayato Konno, Hajime Saito, Hiroshi Nanjo, Yuko Hiroshima, Nobuyasu Kurihara, Satoshi Fujishima, Maiko Atari, Yusuke Sato, Satoru Motoyama, Ryuta Nakamura, Yoichi Akagami, Yoshihiro Minamiya
BACKGROUND: Intraoperative pathologic diagnosis of solitary pulmonary tumors to differentiate between metastatic and primary lung cancer is extremely important to determine the appropriate range of excision. Accurate intraoperative pathologic evaluation may be often difficult, however, and needs additional immunohistochemical (IHC) evaluation to support the diagnosis. Although conventional IHC is a powerful tool for diagnosis, its clinical use is limited intraoperatively because of time constraints...
May 17, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28527245/-description-of-mycobacterium-tuberculosis-mutations-conferring-resistance-to-rifampicin-and-isoniazid-detected-by-genotype%C3%A2-mtbdrplus-v-2-in-colombia
#2
Claudia Llerena, Raquel Medina
INTRODUCTION: The GenoType®MTBDRplusV.2 assay is a molecular technique endorsed by the World Health Organization and the Pan American Health Organization that allows for the identification of the Mycobacterium tuberculosis complex and the detection of mutations in the rpoβ gene for rifampicin resistance, and katG and inhA genes for isoniazid resistance. Due to the genetic variability in the circulating strains around the world, the national tuberculosis control programs should assess the performance of these new diagnostic technologies and their use under program conditions as rapid tests...
January 24, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28525721/development-and-application-of-a-screening-method-of-absolute-qpcr-to-detect-the-abuse-of-sex-steroid-hormone-administration-in-male-bovine
#3
Laura Starvaggi Cuccuzza, Bartolomeo Biolatti, Sara Divari, Paola Pregel, Frine E Scaglione, Alessandra Sereno, Francesca T Cannizzo
A method for absolute quantification of regucalcin gene by quantitative PCR was developed to confirm that the decrease of regucalcin gene expression in the testis is a valid biomarker for detection of sex steroid hormone treatment in bovine husbandry. An external standard curve was developed with TaqMan technology. Based on in vivo experiments, specificity, sensitivity and criterion value of this potential biomarker were calculated by means of a ROC curve. Then, regucalcin gene expression was evaluated in beef and veal calves for human consumption...
May 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28525681/unveiling-idiopathic-macular-telangiectasia-clinical-applications-of-optical-coherence-tomography-angiography
#4
Marco A Gonzalez, Diana Shechtman, Jay M Haynie, Leo Semes
PURPOSE: Idiopathic macular telangiectasia type 2 (IMT2) is a bilateral acquired maculopathy, with a spectrum of clinical presentations associated with inner retinal telangiectatic vascular anomalies. Cases often are underdiagnosed or misdiagnosed. Current diagnostic modalities such as spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) are valuable to the understanding of the clinicopathology. More recently, optical coherence tomography angiography (OCTA), as an emerging noninvasive technology, has been shown to be particularly useful in the assessment and management of IMT2...
May 19, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28524668/emerging-trends-in-micro-and-nanoscale-technologies-in-medicine-from-basic-discoveries-to-translation
#5
Mario M Alvarez, Joanna Aizenberg, Mostafa Analoui, Anne M Andrews, Gili Bisker, Edward S Boyden, Roger D Kamm, Jeffrey M Karp, David J Mooney, Rahmi Oklu, Dan Peer, Michelle Stolzoff, Michael S Strano, Grissel Trujillo-de Santiago, Thomas J Webster, Paul S Weiss, Ali Khademhosseini
We discuss the state of the art and innovative micro- and nanoscale technologies that are finding niches and opening up new opportunities in medicine, particularly in diagnostic and therapeutic applications. We take the design of point-of-care applications and the capture of circulating tumor cells as illustrative examples of the integration of micro- and nanotechnologies into solutions of diagnostic challenges. We describe several novel nanotechnologies that enable imaging cellular structures and molecular events...
May 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28524002/mirna-expression-in-bladder-cancer-and-their-potential-role-in-clinical-practice
#6
Ana Blanca, Liang Cheng, Rodolfo Montironi, Holger Moch, Francesco Massari, Michelangelo Fiorentino, Maria Rosaria Raspollini, Marina Scarpelli, Antonio Lopez-Beltran
To date more than 3000 miRNA sequences have been described in humans and reg¬istered at miRBase since their discovery. However, the functions of only a few of these miRNAs have been experimentally determined using deep sequencing technology. Aberrant miRNA expression has been associated with differentiation, invasion and metastasis in several cancers. In this context, recent reports have suggested that miRNAs play important roles in the regulation of target genes by binding to complementary regions of messenger transcripts to repress their translation or regulate degradation...
May 18, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28523494/-a-future-amalgamation-between-the-scientist-and-the-clinician
#7
Sarah Haywood-Small
Personalized medicine is gaining momentum and analytical methods such as MS are ideally situated to provide coherent imaging of human disease. The cancer research field is already starting to benefit from the MS imaging applications; non-cancerous diseases will hopefully enjoy the same success. Often, the way forward is to embrace several techniques, which can complement and verify each other. This approach can be seen as less confrontational as everyone can play a part in the development of a new working practice...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28523429/kir-lilrb-and-their-ligands-genes-as-potential-biomarkers-in-recurrent-implantation-failure
#8
REVIEW
Izabela Nowak, Karolina Wilczyńska, Jacek R Wilczyński, Andrzej Malinowski, Paweł Radwan, Michał Radwan, Piotr Kuśnierczyk
Reproductive failure in humans is a very important social and economic problem, because nowadays women decide to conceive later in life and delay motherhood. Unfortunately, with increasing age they have less chance for natural fertilization and maintenance of pregnancy. Many of them need assisted reproductive technology. Approximately 10% of women after in vitro fertilization-embryo transfers experience recurrent implantation failure (RIF). Multiple factors may contribute to RIF, including oocyte and sperm quality, parental chromosomal anomalies, genetic or metabolic abnormalities of the embryo, poor uterine receptivity, immunological disturbances in the implantation site, and some gynecologic pathologies such as endometriosis, uterine fibroids, hydrosalpinx and endometrial polyps...
May 18, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28523273/novel-treponema-pallidum-recombinant-antigens-for-syphilis-diagnostics-current-status-and-future-prospects
#9
REVIEW
Aleksey Kubanov, Anastassia Runina, Dmitry Deryabin
The recombinant protein technology considerably promoted the development of rapid and accurate treponema-specific laboratory diagnostics of syphilis infection. For the last ten years, the immunodominant recombinant inner membrane lipoproteins are proved to be sensitive and specific antigens for syphilis screening. However, the development of an enlarged T. pallidum antigen panel for diagnostics of early and late syphilis and differentiation of syphilis stages or cured syphilis remains as actual goal of multidisciplinary expertise...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28522247/potential-of-multi-component-antigens-for-tuberculosis-diagnosis
#10
Sana Khurshid, Madeeha Afzal, Ruqqya Khalid, M Waheed Akhtar, Mahmood Husain Qazi
Tuberculosis is one of the top ten causes of deaths worldwide. The cause of tuberculosis is a bacterium, Mycobacterium tuberculosis, which has been surviving for centuries. Immunological tests based on detecting the presence of antibodies in the sera of active TB patients against various antigens of M. tuberculosis are useful for diagnosis of TB and offer simple, rapid and cost effective methods most suitable for poor and developing countries. Several recombinant antigens have been reported so far with varying sensitivity individually, yet none had shown sensitivity higher enough to be used in a commercial test...
May 15, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28516980/modern-management-of-paediatric-obstructive-salivary-disorders-long-term-clinical-experience
#11
P Capaccio, P Canzi, M Gaffuri, A Occhini, M Benazzo, F Ottaviani, L Pignataro
Recent technological improvements in head and neck field have changed diagnostic and therapeutic strategies for salivary disorders. Diagnosis is now based on colour Doppler ultrasonography (US), magnetic resonance (MR) sialography and cone beam 3D computed tomography (CT), and extra- and intracorporeal lithotripsy, interventional sialendscopy and sialendoscopy-assisted surgery are used as minimally invasive, conservative procedures for functional preservation of the affected gland. We evaluated the results of our long-term experience in the management of paediatric obstructive salivary disorders...
April 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28516971/salivary-biomarkers-and-proteomics-future-diagnostic-and-clinical-utilities
#12
M Castagnola, E Scarano, G C Passali, I Messana, T Cabras, F Iavarone, G Di Cintio, A Fiorita, E De Corso, G Paludetti
Saliva testing is a non-invasive and inexpensive test that can serve as a source of information useful for diagnosis of disease. As we enter the era of genomic technologies and -omic research, collection of saliva has increased. Recent proteomic platforms have analysed the human salivary proteome and characterised about 3000 differentially expressed proteins and peptides: in saliva, more than 90% of proteins in weight are derived from the secretion of three couples of "major" glands; all the other components are derived from minor glands, gingival crevicular fluid, mucosal exudates and oral microflora...
April 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28516345/performance-and-cost-evaluation-of-health-information-systems-using-micro-costing-and-discrete-event-simulation
#13
Olfa Rejeb, Claire Pilet, Sabri Hamana, Xiaolan Xie, Thierry Durand, Saber Aloui, Anne Doly, Pierre Biron, Lionel Perrier, Vincent Augusto
Innovation and health-care funding reforms have contributed to the deployment of Information and Communication Technology (ICT) to improve patient care. Many health-care organizations considered the application of ICT as a crucial key to enhance health-care management. The purpose of this paper is to provide a methodology to assess the organizational impact of high-level Health Information System (HIS) on patient pathway. We propose an integrated performance evaluation of HIS approach through the combination of formal modeling using the Architecture of Integrated Information Systems (ARIS) models, a micro-costing approach for cost evaluation, and a Discrete-Event Simulation (DES) approach...
May 17, 2017: Health Care Management Science
https://www.readbyqxmd.com/read/28515901/experimental-identification-and-computational-characterization-of-a-novel-extracellular-metalloproteinase-produced-by-clostridium-sordellii
#14
Michael J Aldape, Aoxiang Tao, Dustin D Heeney, Eric R McIndoo, John M French, Dong Xu
Clostridium sordellii is a lethal pathogen for both animals and humans. Severe capillary leakage, toxic shock syndrome, and an extreme leukemoid reaction (LR), are hallmark features of C. sordellii infections and contribute to its high mortality rate. Here we report the discovery of a previously unknown and uncharacterized metalloproteinase of C. sordellii (referred as Mcs1) that cleaves human vascular cell adhesion molecule (VCAM)-1 in vitro, an adhesion molecule critical to hematopoietic precursor retention and leukocyte diapedesis...
March 2, 2017: RSC Advances
https://www.readbyqxmd.com/read/28515761/oligonucleotide-aptamers-potential-novel-molecules-against-viral-hepatitis
#15
REVIEW
Mina Mirian, Hossein Khanahmad, Leila Darzi, Mansour Salehi, Hojjat Sadeghi-Aliabadi
Viral hepatitis, as an international public health concern, seriously affects communities and health system. In recent years, great strides have been taken for development of new potential tools against viral hepatitis. Among these efforts, a valuable strategy introduced new molecules called "aptamers". Aptamers as potential alternatives for antibodies could be directed against any protein in infected cells and any components of viral particles. In this review, we will focus on recent advances in the diagnosis and treatment of viral hepatitis based on aptamer technology...
April 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28515084/novel-diagnostic-technologies-for-clinical-and-frontline-use-advanced-diagnostics-based-on-molecular-markers-and-analysis-technologies-has-been-improving-diagnosis-across-a-wide-range-of-diseases
#16
https://www.readbyqxmd.com/read/28514384/-innovative-endoscopic-technologies-in-multi-field-medical-facility
#17
O E Karpov, P S Vetshev, A S Maady, K I Alekseev, A S Osipov, I V Vasiliev
The modern clinical practice is characterized by intensive introduction of innovative technologies for improving treatment and diagnostic procedures, minimizing their impact on the patient, complications rate and economic reasons. One of the priorities in this area is both diagnostic and therapeutic endoscopy. The degree of practical use of innovative endoscopic technologies depends on not only the quality of care, but also their economic reasons. Endoscopic treatment has become the method of choice for gastrointestional bleeding, extraction of foreign bodies, obstructive jaundice, polyps of the gastrointestinal tract, achalasia, esophageal strictures, etc...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28513924/glycan-fingerprinting-using-cold-ion-infrared-spectroscopy
#18
Eike Mucha, Ana Isabel González Flórez, Mateusz Marianski, Daniel A Thomas, Waldemar Hoffmann, Weston B Struwe, Heung S Hahm, Sandy Gewinner, Wieland Schöllkopf, Peter H Seeberger, Gert von Helden, Kevin Pagel
The diversity of stereochemical isomers present in glycans and glycoconjugates poses a formidable challenge for comprehensive structural analysis. Typically, sophisticated mass spectrometry (MS)-based techniques are used in combination with chromatography or ion mobility separation. However, coexisting structurally similar isomers often render an unambiguous identification impossible. Other powerful techniques such as gas-phase infrared (IR) spectroscopy have been limited to smaller glycans, as conformational flexibility and thermal activation during the measurement result in poor spectral resolution...
May 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28511723/feasibility-and-diagnostic-performance-of-dual-tracer-guided-sentinel-lymph-node-biopsy-in-ct1-2n0m0-gastric-cancer-a-systematic-review-and-meta-analysis-of-diagnostic-studies
#19
REVIEW
Ling Huang, Tao Wei, Junjun Chen, Donghui Zhou
BACKGROUND: Dual-tracer-guided sentinel lymph node (SLN) biopsy may provide a promising diagnostic tool to assess accurately the status of lymph node metastasis in the surgical operation and assure the oncologic safety of the function or stomach preserving surgery. The diagnostic performance of this technology in recent studies varied. Thus, we conducted this meta-analysis. METHODS: This systematic review and meta-analysis was registered at the PROSPERO. Eligible studies were searched in the PubMed, EMBASE, Web of Knowledge, and Cochrane Library databases...
May 16, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28511705/pd-l1-expressing-circulating-tumour-cells-in-head-and-neck-cancers
#20
Arutha Kulasinghe, Chris Perry, Liz Kenny, Majid E Warkiani, Colleen Nelson, Chamindie Punyadeera
BACKGROUND: Blockade of the PD-1/PD-L1 immune checkpoint pathway is emerging as a promising immunotherapeutic approach for the management and treatment of head and neck cancer patients who do not respond to 1st/2nd line therapy. However, as checkpoint inhibitors are cost intensive, identifying patients who would most likely benefit from anti PD-L1 therapy is required. Developing a non-invasive technique would be of major benefit to the patient and to the health care system. CASE PRESENTATION: We report the case of a 56 year old man affected by a supraglottic squamous cell carcinoma (SCC)...
May 16, 2017: BMC Cancer
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