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https://www.readbyqxmd.com/read/29775734/defining-the-osteoarthritis-patient-back-to-the-future
#1
REVIEW
Geoffrey P Dobson, Hayley L Letson, Andrea Grant, Peter McEwen, Kaushik Hazratwala, Matthew Wilkinson, Jodie L Morris
The history of osteoarthritis (OA) is important because it can help broaden our perspective on past and present controversies. The naming of OA, beginning with Heberden's nodes, is itself a fascinating story. According to Albert Hoffa, R. Llewellyn Jones and Archibald Edward Garrod, the name OA was introduced in the mid-19th century by surgeon Richard von Volkmann who distinguished it from rheumatoid arthritis and gout. Others preferred the terms 'chronical rheumatism', 'senile arthritis', 'hypertrophic arthritis' or 'arthritis deformans'...
May 15, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29775073/diffuse-gliomas-for-nonneuropathologists-the-new-integrated-molecular-diagnostics
#2
Sunhee C Lee
Diffuse gliomas comprise the bulk of "brain cancer" in adults. The recent update to the 4th edition of the World Health Organization's classification of tumors of the central nervous system reflects an unprecedented change in the landscape of the diagnosis and management of diffuse gliomas that will affect all those involved in the management and care of patients. Of the recently discovered gene alterations, mutations in the Krebs cycle enzymes isocitrate dehydrogenases (IDHs) 1 and 2 have fundamentally changed the way the gliomas are understood and classified...
May 18, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29775022/-establishment-of-the-characterization-of-an-adult-digits-in-noise-test-based-on-internet
#3
B E Qi, T B Zhang, X X Fu, G P Li
Objective: The aim of this study is to explore the sensitivity and specificity of the internet-based digital noise threshold (DIN) test for detecting noise-induced hearing loss, expecting to provide a rapid and effective screening tool for clinical application. Method: This study enrolled 50 adult subjects, of which 34 were normal hearing (NH), 16 patients with sensorineural hearing loss (SNHL). Pure-tone audiometry, acoustic immittance and DIN test were tested respectively. Pearson's correlation coefficient was used to analyze the correlation between NH and SNHL...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774712/-diagnostic-imaging-procedures-and-prescribing-appropriateness-are-administrative-data-a-proper-instrument-an-experience-from-piedmont-region-northern-italy
#4
Eva Pagano, Laura Crosetto, Andrea Evangelista, Chiara Monagheddu, Ottavio Davini, Giulio Fornero, Ida Raciti, Guido Giustetto, Giovannino Ciccone
OBJECTIVES: to assess at population level if healthcare administrative data can be suitable to identify variability and determinants of the prescribing rates for some diagnostic imaging procedures at high-risk of inappropriateness. DESIGN: population-based observational study. SETTING AND PARTICIPANTS: Piedmont Region (Northern Italy) adult population (>20 years) in year 2013. The subjects included were 3,566,147, referring to 3,016 general practitioners (GPs), in 12 Local Health Authorities (LHAs)...
March 2018: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29774630/the-emerging-roles-of-long-non-coding-rna-in-cancer
#5
Anna Sanchez Calle, Yumi Kawamura, Yusuke Yamamoto, Fumitaka Takeshita, Takahiro Ochiya
Since comprehensive analysis of the mammalian genome has revealed that the vast majority of genomic products are transcribed in long non-coding RNAs (lncRNAs), increasing attention has been paid towards these transcripts. The applied next-generation sequencing technologies have provided accumulating evidence of dysregulated lncRNAs in cancer. The implication of this finding may be seen in many forms and at multiple levels. With impacts ranging from integrating chromatin remodeling complexes to regulating transcription and post-transcriptional processes, aberrant expression of lncRNAs may have repercussions in cell proliferation, tumor progression or metastasis...
May 17, 2018: Cancer Science
https://www.readbyqxmd.com/read/29774071/molecular-detection-and-analysis-of-exosomes-using-surface-enhanced-raman-scattering-gold-nanorods-and-a-miniaturized-device
#6
Elyahb Allie Kwizera, Ryan O'Connor, Vojtech Vinduska, Melody Williams, Elizabeth R Butch, Scott E Snyder, Xiang Chen, Xiaohua Huang
Exosomes are a potential source of cancer biomarkers. Probing tumor-derived exosomes can offer a potential non-invasive way to diagnose cancer, assess cancer progression, and monitor treatment responses. Novel molecular methods would facilitate exosome analysis and accelerate basic and clinical exosome research. Methods: A standard gold-coated glass microscopy slide was used to develop a miniaturized affinity-based device to capture exosomes in a target-specific manner with the assistance of low-cost 3-D printing technology...
2018: Theranostics
https://www.readbyqxmd.com/read/29773657/review-of-the-role-of-nice-in-promoting-the-adoption-of-innovative-cardiac-technologies
#7
REVIEW
Peter H Groves, Chris Pomfrett, Mirella Marlow
The National Institute for Health and Care Excellence (NICE) Medical Technologies Evaluation Programme (MTEP) promotes the adoption of innovative diagnostic and therapeutic technologies into National Health Service (NHS) clinical practice through the publication of guidance and briefing documents. Since the inception of the programme in 2009, there have been 7 medical technologiesguidance, 3 diagnostics guidance and 23 medtechinnovation briefing documents published that are relevant to the heart and circulation...
May 17, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29773319/advancements-in-nanomedicine-for-multiple-myeloma
#8
REVIEW
Alexandre Detappe, Mark Bustoros, Tarek H Mouhieddine, P Peter Ghoroghchian
In the past decades, considerable progress has been made in our understanding and treatment of multiple myeloma. Several challenges remain including our abilities to longitudinally image tumor responses to treatment, to combine various therapeutic agents with different mechanisms of action but with overlapping toxicities, and to efficiently harness the power of the immune system to augment remission and/or to induce permanent cures. Nanomedicine may help to address many of these outstanding issues, affording novel diagnostic capabilities and offering disruptive technologies that promise to revolutionize treatment...
May 14, 2018: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/29772963/simplifying-skin-disease-diagnosis-with-topical-nanotechnology
#9
David C Yeo, Chenjie Xu
A new study published in the journal Nature Biomedical Engineering1 documents a novel diagnostic technology that exploits topically applied nanotechnology to detect skin tissue biomarkers for diagnosis. This concept is demonstrated by noninvasively imaging connective tissue growth factor (CTGF) mRNA in abnormal scar cells, whole tissue, and animal models. In this commentary, we highlight the main findings and discuss their implications. Successful implementation in the clinic could give rise to self-applied, biopsy-free diagnostic technology and significantly reduce healthcare burden...
May 1, 2018: SLAS Technology
https://www.readbyqxmd.com/read/29771531/exosomes-as-a-drug-delivery-system-in-cancer-therapy-potential-and-challenges
#10
Golam Kibria, Erika Kathryn Ramos, David R Gius, Yong Wan, Huiping Liu
Exosomes play a pivotal role in mediating intercellular communications and package delivery. They have recently been discovered to serve as diagnostic biomarkers as well as a possible drug delivery vehicle based on their nanometer size range and capability to transfer biological materials to recipient cells. Their unique biocompatibility, high stability, preferred tumor homing, and adjustable targeting efficiency can make exosomes an attractive and potentially effective tool of drug delivery in cancer therapy...
May 17, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29771000/molecular-testing-in-holoprosencephaly
#11
Paul Kruszka, Ariel F Martinez, Maximilian Muenke
Holoprosencephaly (HPE) is a structural brain anomaly characterized by failure of the forebrain to separate during early embryogenesis. Both genetic and environmental etiologies of HPE have been discovered over the last three decades. Traditionally, the genetic workup for HPE has been a karyotype, chromosomal microarray, and/or Sanger sequencing of select genes. The recent increased availability of next-generation sequencing has changed the molecular diagnostic landscape for HPE, associating new genes with this disorder such as FGFR1...
May 17, 2018: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/29770781/eus-guided-tissue-sampling-with-a-20-gauge-core-biopsy-needle-for-the-characterization-of-gastrointestinal-subepithelial-lesions-a-multicenter-study
#12
Filippo Antonini, Gabriele Delconte, Lorenzo Fuccio, Germana De Nucci, Carlo Fabbri, Elia Armellini, Leonardo Frazzoni, Adele Fornelli, Andrea Magarotto, Enzo Mandelli, Pietro Occhipinti, Enzo Masci, Gianpiero Manes, Giampiero Macarri
Background and Objective: A new 20-gauge (G) biopsy needle with a core-trap technology has been developed with a large core size and enhanced flexibility. The aim of this multicenter study was to determine the feasibility, efficacy, and safety of EUS-guided fine-needle biopsy (EUS-FNB) with the new 20G needle in diagnosing subepithelial lesions (SELs). Materials and Methods: Retrospectively collected data from consecutive patients with SELs undergoing EUS-FNB with the 20G needle at five centers were analyzed...
May 17, 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29769805/genome-wide-sequencing-technologies-a-primer-for-paediatricians
#13
Robin Z Hayeems, Kym M Boycott
Genetic testing has been a routine part of paediatic medicine for decades. Over time, the number of genetic tests available for children presenting with features thought to be explained by an underlying genetic aetiology has expanded considerably. Genome-wide sequencing approaches (e.g., whole-exome sequencing, whole-genome sequencing) are now emerging as the most comprehensive approaches to genetic diagnosis that we have seen to date; multiple serial tests that were once required for a child under diagnostic investigation can now be accomplished in a single assay...
May 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29769579/hla-class-ii-haplotypes-and-autism-spectrum-disorders
#14
Meriem Bennabi, Alexandru Gaman, Richard Delorme, Wahid Boukouaci, Céline Manier, Isabelle Scheid, Nassima Si Mohammed, Djaouida Bengoufa, Dominique Charron, Rajagopal Krishnamoorthy, Marion Leboyer, Ryad Tamouza
Infections and autoimmunity are associated with autism spectrum disorders (ASD), with both strongly influenced by the genetic regulation of the human leukocyte antigen (HLA) system. The relationship between ASD and the HLA genetic diversity requires further investigation. Using a case control design, the distribution of HLA class II-DRB1 and DQB1 alleles, genotypes and haplotypes were investigated in ASD patients, versus healthy controls (HC). ASD patients meeting DSM-IV TR criteria and HC (474 and 350 respectively) were genotyped at medium resolution using a Luminex-based SSO technology...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769417/lactate-in-cardiogenic-shock-current-understanding-and-clinical-implications
#15
G M Kubiak, A R Tomasik, K Bartus, R Olszanecki, P Ceranowicz
Adenosine triphosphate (ATP) is an essential substrate metabolite in human beings. Mitochondrial oxidative phosphorylation provides > 95% of ATP with the remainder derived from glycolysis or tricarboxylic acid cycle (TCA). In normal hearts, acetyl-CoA is synthesized from the β-oxidation of free fatty acids (FFA) and the oxidation of pyruvate. Pyruvate is synthesized from glycolysis and can be submitted either for decarboxylation to acetyl-CoA or for dehydrogenation to lactate. Moreover, pyruvate, as well as lactate, plays a key role in aerobic glucose metabolism which is highly dependent on ubiquitous regulatory mechanisms...
February 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29769280/molecular-diagnosis-of-bacterial-vaginosis-an-update
#16
Jenell S Coleman, Charlotte A Gaydos
Bacterial vaginosis (BV) is the most common cause of vaginal discharge in reproductive age women. BV has been associated with poor reproductive outcomes like preterm delivery, acquisition of sexually transmitted infections including HIV, and pelvic inflammatory disease. BV represents acquisition of a diverse community of anaerobic and facultative bacteria and a reduction in lactobacilli. It can be diagnosed using several tests ranging from clinical indicators, point-of-care tests, and molecular assays. Molecular technologies are objective, able to detect fastidious bacteria, allow quantitation, and are ideal for self-collected vaginal swabs...
May 16, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29769278/a-concise-review-of-the-epidemiology-and-diagnostics-of-rickettsioses-rickettsia-and-orientia-spp
#17
Mohammad Yazid Abdad, Rita Abou Abdallah, Pierre-Edouard Fournier, John Stenos, Shawn Vasoo
Rickettsioses are globally distributed and caused by the family Rickettsiaceae , which comprise a diverse and expanding list. These include two genera: Rickettsia and Orientia Serology has been traditionally the main-stay of diagnosis, although this has been limited by cross-reactions among closely related members and diminished sensitivity/utility in the acute phase of illness. Other techniques such as nucleic acid amplification tests using blood specimens or tissue swabs/biopsies, sequencing and mass-spectrometry have emerged in recent years for both pathogen and vector identification...
May 16, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29769059/a-mooc-as-an-immediate-strategy-to-train-health-personnel-in-the-cholera-outbreak-in-mexico
#18
Laura Magaña-Valladares, Cynthia Rosas-Magallanes, Alejandra Montoya-Rodríguez, Guillermo Calvillo-Jacobo, Celia Mercedes Alpuche-Arande, Sebastían García-Saisó
BACKGROUND: In September 2013, two cases of cholera were reported in Mexico; 1 week later, a new outbreak was reported in the Huasteca region of Hidalgo. Upon the determination that the diagnostic and therapeutic interventions implemented by health personnel overlooked predefined procedures, the National Institute of Public Health, in coordination with the Ministry of Health, immediately designed the massive open online course "Proper cholera containment and management measures" to strengthen and standardize basic prevention and control practices...
May 16, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29768933/psychiatric-disorders-in-women-and-men-up-to-five-years-after-undergoing-assisted-reproductive-technology-treatment-a-prospective-cohort-study
#19
Helena Volgsten, Lone Schmidt, Agneta Skoog Svanberg, Lisa Ekselius, Inger Sundström Poromaa
This is a prospective cohort study with the objective to describe psychiatric disorders, such as any mood and anxiety disorders, in both women and men five years after assisted reproductive technology (ART). The Primary Care Evaluation of Mental Disorders (PRIME-MD) questionnaire, based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), was used as the diagnostic tool to evaluate psychiatric disorders. Logistic regression analysis was used to calculate odds ratios (ORs) and confidence interval (CI) for factors associated with psychiatric disorders at the follow-up...
May 17, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29768508/i-scan-optical-enhancement-for-the-in-vivo-prediction-of-diminutive-colorectal-polyp-histology-results-from-a-prospective-three-phased-multicentre-trial
#20
Entcho Klenske, Steffen Zopf, Clemens Neufert, Andreas Nägel, Jürgen Siebler, Jürgen Gschossmann, Steffen Mühldorfer, Lukas Pfeifer, Sarah Fischer, Francesco Vitali, Marietta Iacucci, Subrata Ghosh, Michelle G Rath, Peter Klare, Gian E Tontini, Markus F Neurath, Timo Rath
BACKGROUND AND AIMS: Dye-less chromoendoscopy is an emerging technology for colorectal polyp characterization. Herein, we investigated whether the newly introduced I-scan optical enhancement (OE) can accurately predict polyp histology in vivo in real-time. METHODS: In this prospective three-phased study, 84 patients with 230 diminutive colorectal polyps were included. During the first two study phases, five endoscopists assessed whether analysis of polyp colour, surface and vascular pattern under i-scan OE can differentiate in vivo between adenomatous and hyperplastic polyps...
2018: PloS One
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