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https://www.readbyqxmd.com/read/28231552/progress-and-challenges-in-electrochemiluminescent-aptasensors
#1
REVIEW
Kateryna Muzyka, Muhammad Saqib, Zhongyuan Liu, Wei Zhang, Guobao Xu
The importance of developing new diagnostic and detection technologies for the growing number of sensing challenges is rising each year. Here, we present a comprehensive and concise review on electrochemiluminescent (ECL) aptasensors by putting special emphasis on its characteristic features, advances, challenges, and applications of ECL based aptasensors. ECL is an ideal tool for constructing such sensors because of its inherent characteristics and can be easily integrated into aptamer based sensing platforms...
January 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28230026/the-diagnostic-value-of-contrast-enhanced-computed-tomography-imaging-for-detection-of-colorectal-tumors-a-meta-analysis
#2
Qing Yu, Jie Liu
OBJECTIVE: To evaluate the application usage of contrast-enhanced computer tomography imaging for colorectal tumors diagnosis. METHODS: By searching the Medline and CNKI databases, we collected all diagnostic tests about contrast-enhanced CT imaging for colorectal tumors. Sensitivity and specificity were calculated to evaluate the usage of individual diagnostic tests. The data were analyzed using statistic software Meta-DiSc 1.4. RESULTS: Nine trials that included a total of 4797 patients were analyzed in this study...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28229023/toxgen-an-improved-reference-database-for-the-identification-of-type-b-trichothecene-genotypes-in-fusarium
#3
Tomasz Kulik, Kessy Abarenkov, Maciej Buśko, Katarzyna Bilska, Anne D van Diepeningen, Anna Ostrowska-Kołodziejczak, Katarzyna Krawczyk, Balázs Brankovics, Sebastian Stenglein, Jakub Sawicki, Juliusz Perkowski
Type B trichothecenes, which pose a serious hazard to consumer health, occur worldwide in grains. These mycotoxins are produced mainly by three different trichothecene genotypes/chemotypes: 3ADON (3-acetyldeoxynivalenol), 15ADON (15-acetyldeoxynivalenol) and NIV (nivalenol), named after these three major mycotoxin compounds. Correct identification of these genotypes is elementary for all studies relating to population surveys, fungal ecology and mycotoxicology. Trichothecene producers exhibit enormous strain-dependent chemical diversity, which may result in variation in levels of the genotype's determining toxin and in the production of low to high amounts of atypical compounds...
2017: PeerJ
https://www.readbyqxmd.com/read/28227882/development-and-application-of-human-breast-phantoms-in-microwave-diagnostic-and-therapeutic-technologies
#4
Luz Maria Neira, R Owen Mays, Susan C Hagness, Luz Maria Neira, R Owen Mays, Susan C Hagness, Luz Maria Neira, Susan C Hagness, R Owen Mays
We highlight recent progress in the development of high-fidelity numerical and physical breast phantoms. These phantoms mimic the anatomical structure and physical properties that are relevant to accurately portraying microwave interactions with the human breast. The phantoms are currently being used in numerous laboratory studies of microwave diagnostic and therapeutic technologies for a variety of potential clinical applications in breast health and disease management.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227824/hiv-1-iiib-capture-from-whole-blood-on-magnetic-microparticles
#5
Gregory L Damhorst, Jonathan M Kooiman, Rashid Bashir, Gregory L Damhorst, Jonathan M Kooiman, Rashid Bashir, Gregory L Damhorst, Rashid Bashir, Jonathan M Kooiman
Viral load quantification is a critical need for HIV management worldwide. However, the diagnostic technologies currently available are too limited by their size and expense to reach many remote and resource-limited populations. Toward the development of techniques which can be leveraged for point-of-care assays, we have investigated affinity capture of whole viruses using magnetic microparticles functionalized with antibodies or proteins targeting components of the HIV envelope. Results show the best performance from T-20, a small peptide employed in antiretroviral pharmacotherapy which targets an HIV envelope protein...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227676/initial-experiments-of-a-128-channel-fpga-and-pc-based-ultrasound-imaging-system-for-teaching-and-research-activities
#6
Amauri Amorin Assef, Joaquim Miguel Maia, Eduardo Tavares Costa, Amauri Amorin Assef, Joaquim Miguel Maia, Eduardo Tavares Costa, Amauri Amorin Assef, Joaquim Miguel Maia, Eduardo Tavares Costa
Although widely employed in medical diagnostic applications, most of the available commercial ultrasound (US) scanners do not always fit the needs of research users. Access to raw US data, portability, flexibility and advanced user control are essential features to explore alternative biomedical signal and imaging processing algorithms. In this paper, we present the initial results of a reconfigurable, cost-effective and modular 128-channel FPGA and PC-based US system, specifically designed for teaching and medical imaging research...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227270/deep-learning-framework-for-detection-of-hypoglycemic-episodes-in-children-with-type-1-diabetes
#7
Phyo Phyo San, Sai Ho Ling, Hung T Nguyen, Phyo Phyo San, Sai Ho Ling, Hung T Nguyen, Sai Ho Ling, Hung T Nguyen, Phyo Phyo San
Most Type 1 diabetes mellitus (T1DM) patients have hypoglycemia problem. Low blood glucose, also known as hypoglycemia, can be a dangerous and can result in unconsciousness, seizures and even death. In recent studies, heart rate (HR) and correct QT interval (QTc) of the electrocardiogram (ECG) signal are found as the most common physiological parameters to be effected from hypoglycemic reaction. In this paper, a state-of-the-art intelligent technology namely deep belief network (DBN) is developed as an intelligent diagnostics system to recognize the onset of hypoglycemia...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226879/toward-a-low-cost-gait-analysis-system-for-clinical-and-free-living-assessment
#8
Cassim Ladha, Silvia Del Din, Kianoush Nazarpour, Aodhan Hickey, Rosie Morris, Michael Catt, Lynn Rochester, Alan Godfrey, Cassim Ladha, Silvia Del Din, Kianoush Nazarpour, Aodhan Hickey, Rosie Morris, Michael Catt, Lynn Rochester, Alan Godfrey, Rosie Morris, Cassim Ladha, Lynn Rochester, Alan Godfrey, Aodhan Hickey, Silvia Del Din, Kianoush Nazarpour, Michael Catt
Gait is an important clinical assessment tool since changes in gait may reflect changes in general health. Measurement of gait is a complex process which has been restricted to bespoke clinical facilities until recently. The use of inexpensive wearable technologies is an attractive alternative and offers the potential to assess gait in any environment. In this paper we present the development of a low cost analysis gait system built using entirely open source components. The system is used to capture spatio-temporal gait characteristics derived from an existing conceptual model, sensitive to ageing and neurodegenerative pathology (e...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225893/lncrna-snhg12-promotes-cell-growth-and-inhibits-cell-apoptosis-in-colorectal-cancer-cells
#9
J Z Wang, C L Xu, H Wu, S J Shen
Several long non-coding RNA (lncRNA) might be correlated with the prognosis of colorectal cancer (CRC) and serve as a diagnostic and prognostic biomarker. However, the exact expression pattern of small nucleolar RNA host gene 12 (SNHG12) in colorectal cancer and its clinical significance remains unclear. The level of SNHG12 was detected by qRT-PCR in CRC tissues and CRC cells. MTT assay and colony formation assay were performed to examine the cell proliferation of CRC cells transfected with pcDNA-SNHG12 or si-SNHG12...
February 20, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28225099/ultra-high-throughput-detection-1-million-droplets-per-second-of-fluorescent-droplets-using-a-cell-phone-camera-and-time-domain-encoded-optofluidics
#10
Venkata R Yelleswarapu, Heon-Ho Jeong, Sagar Yadavali, David Issadore
Droplet-based assays-in which ultra-sensitive molecular measurements are made by performing millions of parallel experiments in picoliter droplets-have generated enormous enthusiasm due to their single molecule resolution and robustness to reaction conditions. These assays have great untapped potential for point of care diagnostics but are currently confined to laboratory settings due to the instrumentation necessary to serially generate, control, and measure tens of millions of droplets. To address this challenge, we have developed the microdroplet megascale detector (μMD) that can generate and detect the fluorescence of millions of droplets per second (1000× faster than conventional approaches) using only a conventional cell phone camera...
February 22, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28224304/visualization-of-draining-vein-in-focal-nodular-hyperplasia-by-superb-microvascular-imaging-report-of-two-cases
#11
Hiroko Naganuma, Hideaki Ishida, Masahiro Ogawa, Katsunori Suzuki
Focal nodular hyperplasia (FNH) is the second most common benign tumor of the liver, and diagnosis and follow-up without invasive procedures are now highly recommended. FNH shows a characteristic vascular structure called "spoke-wheel appearance". However, this appearance relies on the mode of the feeding artery, and the mode of the draining vein has not been sufficiently studied until recently. Superb microvascular imaging (SMI) is a new Doppler technology designed to improve visualization of the blood flow, especially slow flow signals from fine vessels, using a new algorithm...
February 21, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28224187/-internet-and-mobile-based-approaches-psycho-social-diagnostics-and-treatment-in-medical-rehabilitation
#12
Harald Baumeister, Jiaxi Lin, David Daniel Ebert
Technology-based approaches for psychosocial diagnostics and interventions provide an attractive opportunity to optimize medical rehabilitation. Based on an Internet- and mobile-based assessment of existing functional health impairments, appropriate planning, implementation of corresponding courses of action as well as outcome assessment can take place. This can be implemented in the form of Internet- and mobile-based interventions (IMI).The present article provides an overview of the basic knowledge of IMI and their evidence base both in general and in particular for their use in medical rehabilitation...
February 21, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28224054/variant-profiling-of-evolving-prokaryotic-populations
#13
Markus Zojer, Lisa N Schuster, Frederik Schulz, Alexander Pfundner, Matthias Horn, Thomas Rattei
Genomic heterogeneity of bacterial species is observed and studied in experimental evolution experiments and clinical diagnostics, and occurs as micro-diversity of natural habitats. The challenge for genome research is to accurately capture this heterogeneity with the currently used short sequencing reads. Recent advances in NGS technologies improved the speed and coverage and thus allowed for deep sequencing of bacterial populations. This facilitates the quantitative assessment of genomic heterogeneity, including low frequency alleles or haplotypes...
2017: PeerJ
https://www.readbyqxmd.com/read/28222680/field-evaluation-of-a-recombinase-polymerase-amplification-assay-for-the-diagnosis-of-schistosoma-japonicum-infection-in-hunan-province-of-china
#14
Weiwei Xing, Xinling Yu, Jingtao Feng, Kui Sun, Wenliang Fu, Yuanyuan Wang, Minji Zou, Wenrong Xia, Zhihong Luo, Hongbin He, Yuesheng Li, Donggang Xu
BACKGROUND: Current diagnostic methods for Schistosoma japonicum infection are insensitive for low-density infections. Therefore, a new diagnostic assay based on recombinase polymerase amplification (RPA) technology was established and assessed for field applification. METHODS: The S.japonicum RPA assay was developed to target highly repetitive retrotransposon SjR2 gene of S japonicum, and its sensitivity and specificity were assessed by serial dilution of S. japonicum genomic DNA and other related worm genomic DNA respectively...
February 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28222368/direct-and-label-free-influenza-virus-detection-based-on-multisite-binding-to-sialic-acid-receptors
#15
Yukichi Horiguchi, Tatsuro Goda, Akira Matsumoto, Hiroaki Takeuchi, Shoji Yamaoka, Yuji Miyahara
A system to discriminate human or avian influenza A remains a highly sought-after tool for prevention of influenza pandemics in humans. Selective binding of the influenza A viral hemagglutinin (HA) to specific sialic acid (SA) receptors (Neu5Acα(2-6)Gal in humans, Neu5Acα(2-3)Gal in birds) is determined by the genotype of the HA and neuraminidase (NA) segments, making it one of the key characteristics that distinguishes human or avian influenza A virus. Here we demonstrate the direct detection of whole H1N1 influenza A virus using 6'-sialyllactose (Neu5Acα(2-6)Galβ(1-4)Glc, 6SL)-immobilized gold electrodes as biosensing surfaces...
February 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28222014/verification-of-examination-procedures-in-clinical-laboratory-for-imprecision-trueness-and-diagnostic-accuracy-according-to-iso-15189-2012-a-pragmatic-approach
#16
Giorgia Antonelli, Andrea Padoan, Ada Aita, Laura Sciacovelli, Mario Plebani
Background The International Standard ISO 15189 is recognized as a valuable guide in ensuring high quality clinical laboratory services and promoting the harmonization of accreditation programmes in laboratory medicine. Examination procedures must be verified in order to guarantee that their performance characteristics are congruent with the intended scope of the test. The aim of the present study was to propose a practice model for implementing procedures employed for the verification of validated examination procedures already used for at least 2 years in our laboratory, in agreement with the ISO 15189 requirement at the Section 5...
February 21, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28220651/elisa-type-assays-of-trace-biomarkers-using-microfluidic-methods
#17
REVIEW
Jinhua Dong, Hiroshi Ueda
Recently, great progress has been achieved for analytical technologies for biological substances. Traditionally, detection methods for analytes mainly rely on large instrumental analyses. These methods require costly equipment, skilled operators and long measurement time despite their generally low sensitivity. In contrast, immunoassays are becoming more and more popular for it is powerful, inexpensive, and convenient nature. Immunoassay has a range of applications, because it employs antibody, a protein produced by plasma cells in the acquired immune system to identify and neutralize diverse pathogens and other exogenous substances...
February 20, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28220508/quantitative-long-term-measurements-of-burns-in-a-rat-model-using-spatial-frequency-domain-imaging-sfdi-and-laser-speckle-imaging-lsi
#18
Adrien Ponticorvo, David M Burmeister, Rebecca Rowland, Melissa Baldado, Gordon T Kennedy, Rolf Saager, Nicole Bernal, Bernard Choi, Anthony J Durkin
BACKGROUND AND OJECTIVES: The current standard for diagnosis of burn severity and subsequent wound healing is through clinical examination, which is highly subjective. Several new technologies are shifting focus to burn care in an attempt to help quantify not only burn depth but also the progress of healing. While accurate early assessment of partial thickness burns is critical for dictating the course of treatment, the ability to quantitatively monitor wound status over time is critical for understanding treatment efficacy...
February 21, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28219002/molecular-testing-for-gastrointestinal-cancer
#19
Hye Seung Lee, Woo Ho Kim, Yoonjin Kwak, Jiwon Koh, Jeong Mo Bae, Kyoung-Mee Kim, Mee Soo Chang, Hye Seung Han, Joon Mee Kim, Hwal Woong Kim, Hee Kyung Chang, Young Hee Choi, Ji Y Park, Mi Jin Gu, Min Jin Lhee, Jung Yeon Kim, Hee Sung Kim, Mee-Yon Cho
With recent advances in molecular diagnostic methods and targeted cancer therapies, several molecular tests have been recommended for gastric cancer (GC) and colorectal cancer (CRC). Microsatellite instability analysis of gastrointestinal cancers is performed to screen for Lynch syndrome, predict favorable prognosis, and screen patients for immunotherapy. The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor has been approved in metastatic CRCs with wild-type RAS (KRAS and NRAS exon 2-4). A BRAF mutation is required for predicting poor prognosis...
February 19, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28218999/assessment-of-morbidity-and-mortality-associated-with-eus-guided-fna-for-pancreatic-cystic-lesions-a-system-review-and-meta-analysis
#20
REVIEW
Huiyun Zhu, Fei Jiang, Jianwei Zhu, Yiqi Du, Zhendong Jin, Zhaoshen Li
BACKGROUND AND AIM: With increased availability of imaging technology, detection of pancreatic cystic lesions (PCLs) is on the rise. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) improves the diagnosis accuracy of PCLs. Systematic evaluation of morbidity and mortality associated with EUS-FNA for PCLs has not been performed. We conducted a systematic review and meta-analysis of morbidity and mortality associated with EUS-FNA. METHODS: A literature search for relevant English-language articles was conducted on PubMed and EMBASE databases...
February 20, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
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