Bijay Pattnaik, Vinny Negi, Rituparna Chaudhuri, Koundinya Desiraju, Md Imam Faizan, Areej Akhtar, Md Sufyan Ansari, Md Shakir, Atish Gheware, Y S Prakash, Randeep Guleria, Balaram Ghosh, Anurag Agrawal, Tanveer Ahmad
Idiopathic Pulmonary Fibrosis (IPF) is a progressively fatal and incurable disease characterized by the loss of alveolar structures, increased epithelial-mesenchymal transition (EMT), and aberrant tissue repair. In this study, we investigated the role of Nuclear Factor I-B (NFIB), a transcription factor critical for lung development and maturation, in IPF. Using both human lung tissue samples from patients with IPF, and a mouse model of lung fibrosis induced by bleomycin, we showed that there was a significant reduction of NFIB both in the lungs of patients and mice with IPF...
November 11, 2023: Cellular and Molecular Life Sciences: CMLS