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Selective Functional Movement Assessment

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https://www.readbyqxmd.com/read/27872281/interactions-of-divalent-cations-with-calcium-binding-sites-of-bk-channels-reveal-independent-motions-within-the-gating-ring
#1
Pablo Miranda, Teresa Giraldez, Miguel Holmgren
Large-conductance voltage- and calcium-activated K(+) (BK) channels are key physiological players in muscle, nerve, and endocrine function by integrating intracellular Ca(2+) and membrane voltage signals. The open probability of BK channels is regulated by the intracellular concentration of divalent cations sensed by a large structure in the BK channel called the "gating ring," which is formed by four tandems of regulator of conductance for K(+) (RCK1 and RCK2) domains. In contrast to Ca(2+) that binds to both RCK domains, Mg(2+), Cd(2+), or Ba(2+) interact preferentially with either one or the other...
November 21, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27859842/movement-reveals-scale-dependence-in-habitat-selection-of-a-large-ungulate
#2
Joseph M Northrup, Charles R Anderson, Mevin B Hooten, George Wittemyer
Ecological processes operate across temporal and spatial scales. Anthropogenic disturbances impact these processes, but examinations of scale dependence in impacts are infrequent. Such examinations can provide important insight to wildlife-human interactions and guide management efforts to reduce impacts. We assessed spatiotemporal scale dependence in habitat selection of mule deer (Odocoileus hemionus) in the Piceance Basin of Colorado, USA, an area of ongoing natural gas development. We employed a newly developed animal movement method to assess habitat selection across scales defined using animal-centric spatiotemporal definitions ranging from the local (defined from five hour movements) to the broad (defined from weekly movements)...
July 27, 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27845501/treatment-for-ulnar-neuropathy-at-the-elbow
#3
REVIEW
Pietro Caliandro, Giuseppe La Torre, Roberto Padua, Fabio Giannini, Luca Padua
BACKGROUND: Ulnar neuropathy at the elbow (UNE) is the second most common entrapment neuropathy after carpal tunnel syndrome. Treatment may be conservative or surgical, but optimal management remains controversial. This is an update of a review first published in 2010 and previously updated in 2012. OBJECTIVES: To determine the effectiveness and safety of conservative and surgical treatment in ulnar neuropathy at the elbow (UNE). We intended to test whether:- surgical treatment is effective in reducing symptoms and signs and in increasing nerve function;- conservative treatment is effective in reducing symptoms and signs and in increasing nerve function;- it is possible to identify the best treatment on the basis of clinical, neurophysiological, or nerve imaging assessment...
November 15, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27843466/the-relationship-between-motor-function-and-behavioral-function-in-infants-with-low-birth-weight
#4
Malek Amini, Faranak Aliabadi, Mehdi Alizade, Majid Kalani, Mostafa Qorbani
OBJECTIVE: Nowadays, the evaluation of all aspects of infant development is important. However, in practice, some of these assessments, especially those requiring more manipulation on high-risk infants, may impose additional stress on them. Therefore, sometimes it is essential to utilize the results of a developmental assessment for the prediction of some other aspects of development. This study evaluated the relationship between the scores of the behavioral tests and the motor function test...
2016: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/27842671/real-time-mri-of-the-temporomandibular-joint-at-15-frames-per-second-a-feasibility-study
#5
Sebastian Krohn, Nikolaus Gersdorff, Torsten Wassmann, Klaus-Dietmar Merboldt, Arun A Joseph, Ralf Buergers, Jens Frahm
The purpose of this study was to develop and evaluate a novel method for real-time MRI of TMJ function at high temporal resolution and with two different contrasts. Real-time MRI was based on undersampled radial fast low angle shot (FLASH) acquisitions with iterative image reconstruction by regularized nonlinear inversion. Real-time MRI movies with T1 contrast were obtained with use of a radiofrequency-spoiled FLASH sequence, while movies with T2/T1 contrast employed a gradient-refocused FLASH version. TMJ function was characterized in 40 randomly selected volunteers by sequential 20s acquisitions of both the right and left joint during voluntary opening and closing of the mouth (in a medial, central and lateral oblique sagittal section perpendicular to the long axis of the condylar head)...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27814307/effect-of-shock-wave-therapy-on-ankle-planter-flexors-spasticity-in-stroke-patients
#6
Salah Sawan, Foad Abd-Allah, Montasser M Hegazy, Mohammad A Farrag, Nancy Hosney Sharf El-Den
BACKGROUND: Large number of patients with first-ever stroke developed spasticity. Spasticity can reduce the range of motion, hinder voluntary movements, provoke pain, and result in impairment of functional activities of daily living. OBJECTIVE: Demonstrate the effect of shock wave therapy on ankle planter flexors spasticity in stroke patients. METHODS: We included forty ischemic stroke patients divided into 2 groups; group I were subjected to the selected physical therapy program and shock wave therapy whereas group II received the selected physical therapy program as well as placebo shock wave for six weeks...
October 31, 2016: NeuroRehabilitation
https://www.readbyqxmd.com/read/27803635/discriminating-talent-identified-junior-australian-footballers-using-a-fundamental-gross-athletic-movement-assessment
#7
Carl T Woods, Harry G Banyard, Ian McKeown, Job Fransen, Sam Robertson
Talent identification (TID) is a pertinent component of the sports sciences, affording practitioners the opportunity to target developmental interventions to a select few; optimising financial investments. However, TID is multi-componential, requiring the recognition of immediate and prospective performance. The measurement of athletic movement skill may afford practitioners insight into the latter component given its augmented relationship with functional sport specific qualities. It is currently unknown whether athletic movement skill is a discriminant quality in junior Australian football (AF)...
September 2016: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/27794362/robotic-quantification-of-upper-extremity-loss-of-independent-joint-control-or-flexion-synergy-in-individuals-with-hemiparetic-stroke-a-review-of-paradigms-addressing-the-effects-of-shoulder-abduction-loading
#8
REVIEW
Michael D Ellis, Yiyun Lan, Jun Yao, Julius P A Dewald
Unsupported or "against-gravity" reaching and hand opening movements are greatly impaired in individuals with hemiparetic stroke. The reduction in reaching excursion and hand opening is thought to be primarily limited by abnormal muscle co-activation of shoulder abductors with distal limb flexors, known as flexion synergy, that results in a loss of independent joint control or joint individuation. Our laboratory employs several methods for quantifying this movement impairment, however the most documented techniques are sophisticated and laboratory-based...
October 29, 2016: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/27789762/motor-learning-in-stroke-trained-patients-are-not-equal-to-untrained-patients-with-less-impairment
#9
Robert M Hardwick, Vikram A Rajan, Amy J Bastian, John W Krakauer, Pablo A Celnik
BACKGROUND AND OBJECTIVE: Stroke rehabilitation assumes motor learning contributes to motor recovery, yet motor learning in stroke has received little systematic investigation. Here we aimed to illustrate that despite matching levels of performance on a task, a trained patient should not be considered equal to an untrained patient with less impairment. METHODS: We examined motor learning in healthy control participants and groups of stroke survivors with mild-to-moderate or moderate-to-severe motor impairment...
October 27, 2016: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/27776222/neck-dissection-s-burden-on-the-patient-functional-and-psychosocial-aspects-in-1-652-patients-with-oral-squamous-cell-carcinomas
#10
Simon Spalthoff, Rüdiger Zimmerer, Philipp Jehn, Nils-Claudius Gellrich, Jörg Handschel, Gertrud Krüskemper
PURPOSE: In this study of patients with oral squamous cell carcinoma, the authors sought to clarify the functional and psychosocial harms of neck dissection (ND), which lessens quality of life. MATERIALS AND METHODS: The study included questionnaire responses from patients with oral squamous cell carcinoma (n = 1,652) and clinicians (n = 1,489), as collected in the DÖSAK Rehab Study. Psychosocial and functional factors were assessed. Functional and psychosocial outcomes in patients who did not receive ND were compared with those in patients who underwent selective supraomohyoid ND (SND), modified radical ND (MND), and radical ND (RND)...
September 28, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27752515/rapid-number-naming-in-chronic-concussion-eye-movements-in-the-king-devick-test
#11
John-Ross Rizzo, Todd E Hudson, Weiwei Dai, Joel Birkemeier, Rosa M Pasculli, Ivan Selesnick, Laura J Balcer, Steven L Galetta, Janet C Rucker
OBJECTIVE: The King-Devick (KD) test, which is based on rapid number naming speed, is a performance measure that adds vision and eye movement assessments to sideline concussion testing. We performed a laboratory-based study to characterize ocular motor behavior during the KD test in a patient cohort with chronic concussion to identify features associated with prolonged KD reading times. METHODS: Twenty-five patients with a concussion history (mean age: 31) were compared to control participants with no concussion history (n = 42, mean age: 32)...
October 2016: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/27732736/withdrawn-transcutaneous-electrical-stimulation-tes-for-treatment-of-constipation-in-children
#12
Ruey Terng Ng, Way Seah Lee, Hak Lee Ang, Kai Ming Teo, Yee Ian Yik, Nai Ming Lai
BACKGROUND: Childhood constipation is a common problem with substantial health, economic and emotional burdens. Existing therapeutic options, mainly pharmacological, are not consistently effective, and some are associated with adverse effects after prolonged use. Transcutaneous electrical stimulation (TES), a non-pharmacological approach, is postulated to facilitate bowel movement by modulating the nerves of the large bowel via the application of electrical current transmitted through the abdominal wall...
October 12, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27724945/a-robot-based-behavioural-task-to-quantify-impairments-in-rapid-motor-decisions-and-actions-after-stroke
#13
Teige C Bourke, Catherine R Lowrey, Sean P Dukelow, Stephen D Bagg, Kathleen E Norman, Stephen H Scott
BACKGROUND: Stroke can affect our ability to perform daily activities, although it can be difficult to identify the underlying functional impairment(s). Recent theories highlight the importance of sensory feedback in selecting future motor actions. This selection process can involve multiple processes to achieve a behavioural goal, including selective attention, feature/object recognition, and movement inhibition. These functions are often impaired after stroke, but existing clinical measures tend to explore these processes in isolation and without time constraints...
October 10, 2016: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/27716228/measuring-the-impact-of-migraine-for-evaluating-outcomes-of-preventive-treatments-for-migraine-headaches
#14
Sally Mannix, Anne Skalicky, Dawn C Buse, Pooja Desai, Sandhya Sapra, Brian Ortmeier, Katherine Widnell, Asha Hareendran
BACKGROUND: Migraine is characterized by headache with symptoms such as intense pain, nausea, vomiting, photophobia, and phonophobia that significantly impact individuals' lives. The objective of this study was to develop a strategy to measure outcomes from the patients' perspectives for use in evaluating preventive treatments for migraine. METHODS: This study used a multi-stage process. The first stage included concept identification research through literature review, patient-reported outcome (PRO) instrument content review, and clinician interviews, and resulted in a list of concepts relevant to understand the migraine experience...
October 6, 2016: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/27699718/olfactory-dysfunction-in-parkinson-s-disease-patients-with-the-lrrk2-g2385r-variant
#15
Ming Cao, Zhu-Qin Gu, Yuan Li, Hui Zhang, Xiao-Juan Dan, Shan-Shan Cen, Da-Wei Li, Piu Chan
Olfactory dysfunction has been reported in Parkinson's disease (PD) patients carrying the LRRK2 G2019S variant in Caucasians but rarely in those with the LRRK2 G2385R variant. In this study, we performed genotyping for the LRRK2 G2385R variant in PD patients recruited from the Movement Disorder Clinic of Xuanwu Hospital in Beijing and in healthy controls randomly selected from the Beijing Longitudinal Study on Aging cohort. The "five-odor olfactory detection array", an olfactory threshold test, was used to assess olfactory function...
October 3, 2016: Neuroscience Bulletin
https://www.readbyqxmd.com/read/27637581/technology-based-measurements-for-screening-monitoring-and-preventing-frailty
#16
L Dasenbrock, A Heinks, M Schwenk, J M Bauer
BACKGROUND AND OBJECTIVE: Sensor technology, in particular wearable inertial sensors, has the potential to help researchers objectively assess the functionality of older adults. The following review provides an overview about the possible use of sensor technology to detect and prevent pre-frailty and frailty. METHOD: A systematic literature search in PubMed and the Cochrane Library was conducted. Articles were selected according to the following criteria: frail and/or pre-frail population, use of wearable and non-wearable sensor technology to measure or enhance human movements or activities of daily living and a focus on frailty assessment...
October 2016: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/27583794/robotic-mirror-therapy-system-for-functional-recovery-of-hemiplegic-arms
#17
Jaewon Beom, Sukgyu Koh, Hyung Seok Nam, Wonshik Kim, Yoonjae Kim, Han Gil Seo, Byung-Mo Oh, Sun Gun Chung, Sungwan Kim
Mirror therapy has been performed as effective occupational therapy in a clinical setting for functional recovery of a hemiplegic arm after stroke. It is conducted by eliciting an illusion through use of a mirror as if the hemiplegic arm is moving in real-time while moving the healthy arm. It can facilitate brain neuroplasticity through activation of the sensorimotor cortex. However, conventional mirror therapy has a critical limitation in that the hemiplegic arm is not actually moving. Thus, we developed a real-time 2-axis mirror robot system as a simple add-on module for conventional mirror therapy using a closed feedback mechanism, which enables real-time movement of the hemiplegic arm...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27569394/an-rna-binding-protein-rnp-1-protects-microtubules-from-nocodazole-and-localizes-to-the-leading-edge-during-cytokinesis-and-cell-migration-in-dictyostelium-cells
#18
Thu Ngo, Xin Miao, Douglas N Robinson, Qiong-Qiong Zhou
AIM: RNA-binding proteins are a large group of regulators (800-1000 in humans), some of which play significant roles in mRNA local translation. In this study, we analyzed the functions of the protein RNP-1, which was previously discovered in a genetic selection screen for nocodazole suppression. METHODS: The growth rates and the microtubule networks of Dictyostelium cells were assessed with or without nocodazole (10 μmol/L) in suspension culture. Fluorescent images of RNP-1-GFP and RFP-tubulin were captured when cells were undergoing cytokinesis, then the GFP signal intensity and distance to the nearest centrosome were analyzed by using a computer program written in Matlab(®)...
November 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27539962/effects-of-a-novel-phosphodiesterase-10a-inhibitor-in-non-human-primates-a-therapeutic-approach-for-schizophrenia-with-improved-side-effect-profile
#19
Gunasingh J Masilamoni, Subramanian Uthayathas, Gerhard Koenig, Liza Leventhal, Stella M Papa
Schizophrenia symptoms are associated with alterations in basal ganglia-cortical networks that include the cyclic nucleotides (cAMP/cGMP) signaling pathways. Phosphodiesterase 10A (PDE10A) inhibitors have been considered as therapeutic agents for schizophrenia because the regulation of cAMP and cGMP in the striatum by PDE10A plays an important role in the signaling mechanisms of the striatal-cortical network, and thereby in cognitive function. In the present study we assessed in non-human primates (NHPs) the effects of a novel PDE10A inhibitor (FRM-6308) that has demonstrated high potency and selectivity for human recombinant PDE10A in vitro...
November 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27525187/intervention-at-the-foot-shoe-pedal-interface-in-competitive-cyclists
#20
Sinead FitzGibbon, Bill Vicenzino, Sue Ann Sisto
BACKGROUND: Competitive cyclists are susceptible to injury from the highly repetitive nature of pedaling during training and racing. Deviation from an optimal movement pattern is often cited as a factor contributing to tissue stress with specific concern for excessive frontal plane knee motion. Wedges and orthoses are increasingly used at the foot-shoe-pedal-interface (FSPI) in cycling shoes to alter the kinematics of the lower limb while cycling. Determination of the effect of FSPI alteration on cycling kinematics may offer a simple, inexpensive tool to reduce anterior knee pain in recreational and competitive cyclists...
August 2016: International Journal of Sports Physical Therapy
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