keyword
MENU ▼
Read by QxMD icon Read
search

Functional Movement Systems

keyword
https://www.readbyqxmd.com/read/29217687/role-of-the-axon-initial-segment-in-the-control-of-spontaneous-frequency-of-nigral-dopaminergic-neurons-in-vivo
#1
Rodrigo C Meza, Luciana López-Jury, Carmen C Canavier, Pablo Henny
The spontaneous tonic discharge activity of nigral dopamine neurons plays a fundamental role in dopaminergic signaling. To investigate the role of neuronal morphology and architecture with respect to spontaneous activity in this population, we visualized the 3D structure of the axon initial segment (AIS) along with the entire somatodendritic domain of adult male mouse dopaminergic neurons, previously recorded in vivo We observed a positive correlation of the firing rate with both proximity and size of the AIS...
December 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29213073/reversible-silencing-of-lumbar-spinal-interneurons-unmasks-a-task-specific-network-for-securing-hindlimb-alternation
#2
Amanda M Pocratsky, Darlene A Burke, Johnny R Morehouse, Jason E Beare, Amberly S Riegler, Pantelis Tsoulfas, Gregory J R States, Scott R Whittemore, David S K Magnuson
Neural circuitry in the lumbar spinal cord governs two principal features of locomotion, rhythm and pattern, which reflect intra- and interlimb movement. These features are functionally organized into a hierarchy that precisely controls stepping in a stereotypic, speed-dependent fashion. Here, we show that a specific component of the locomotor pattern can be independently manipulated. Silencing spinal L2 interneurons that project to L5 selectively disrupts hindlimb alternation allowing a continuum of walking to hopping to emerge from the otherwise intact network...
December 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29212790/the-arp2-3-regulatory-system-and-its-deregulation-in-cancer
#3
REVIEW
Nicolas Molinie, Alexis Gautreau
The Arp2/3 complex is an evolutionary conserved molecular machine that generates branched actin networks. When activated, the Arp2/3 complex contributes the actin branched junction and thus cross-links the polymerizing actin filaments in a network that exerts a pushing force. The different activators initiate branched actin networks at the cytosolic surface of different cellular membranes to promote their protrusion, movement, or scission in cell migration and membrane traffic. Here we review the structure, function, and regulation of all the direct regulators of the Arp2/3 complex that induce or inhibit the initiation of a branched actin network and that controls the stability of its branched junctions...
January 1, 2018: Physiological Reviews
https://www.readbyqxmd.com/read/29211997/challenges-in-estimating-the-motility-parameters-of-single-processive-motor-proteins
#4
Felix Ruhnow, Linda Kloβ, Stefan Diez
Cytoskeletal motor proteins are essential to the function of a wide range of intracellular mechano-systems. The biophysical characterization of their movement along their filamentous tracks is therefore of large importance. Toward this end, single-molecule, in vitro stepping-motility assays are commonly used to determine motor velocity and run length. However, comparing results from such experiments has proved difficult due to influences from variations in the experimental conditions and the data analysis methods...
December 5, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29211026/a-review-of-chronic-pain-and-cognitive-mood-and-motor-dysfunction-following-mild-traumatic-brain-injury-complex-comorbid-and-or-overlapping-conditions
#5
REVIEW
Ramesh Grandhi, Samon Tavakoli, Catherine Ortega, Maureen J Simmonds
Mild traumatic brain injury (mTBI) is commonly encountered in clinical practice. While the cognitive ramifications of mTBI are frequently described in the literature, the impact of mTBI on emotional, sensory, and motor function is not as commonly discussed. Chronic pain is a phenomenon more prevalent among patients with mTBI compared to those with moderate or severe traumatic brain injury. Chronic pain can become a primary disorder of the central nervous system (CNS) expressed as widespread pain, and cognitive, mood, and movement dysfunction...
December 6, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29210764/deriving-information-requirements-for-a-smart-nursing-system-for-intensive-care-units
#6
Kunal Khanade, Farzan Sasangohar, Steven C Sutherland, Karen E Alexander
The workplace environment for intensive care nursing is highly stressful, with long working hours and a dynamic workload that may induce fatigue. The resulting stress and fatigue may reduce nurses' efficiency and may contribute to medical errors. A smart wearable system is being designed to help nurses who experience high levels of stress and fatigue at work. This article documents the systematic process of deriving information requirements from 2 focus groups conducted separately with nurses and nurse managers working in various Southeastern Texas hospitals...
January 2018: Critical Care Nursing Quarterly
https://www.readbyqxmd.com/read/29209177/a-new-behavioral-test-and-associated-genetic-tools-highlight-the-function-of-ventral-abdominal-muscles-in-adult-drosophila
#7
Marine Pons, Claire Soulard, Laurent Soustelle, Marie-Laure Parmentier, Yves Grau, Sophie Layalle
The function of the nervous system in complex animals is reflected by the achievement of specific behaviors. For years in Drosophila, both simple and complex behaviors have been studied and their genetic bases have emerged. The neuromuscular junction is maybe one of the prototypal simplest examples. A motor neuron establishes synaptic connections on its muscle cell target and elicits behavior: the muscle contraction. Different muscles in adult fly are related to specific behaviors. For example, the thoracic muscles are associated with flight and the leg muscles are associated with locomotion...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29209162/characterization-of-cochlear-vestibular-and-cochlear-vestibular-electrically-evoked-compound-action-potentials-in-patients-with-a-vestibulo-cochlear-implant
#8
T A K Nguyen, Samuel Cavuscens, Maurizio Ranieri, Konrad Schwarz, Nils Guinand, Raymond van de Berg, Thomas van den Boogert, Floor Lucieer, Marc van Hoof, Jean-Philippe Guyot, Herman Kingma, Silvestro Micera, Angelica Perez Fornos
The peripheral vestibular system is critical for the execution of activities of daily life as it provides movement and orientation information to motor and sensory systems. Patients with bilateral vestibular hypofunction experience a significant decrease in quality of life and have currently no viable treatment option. Vestibular implants could eventually restore vestibular function. Most vestibular implant prototypes to date are modified cochlear implants to fast-track development. These use various objective measurements, such as the electrically evoked compound action potential (eCAP), to supplement behavioral information...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29207002/disability-fatigue-pain-and-their-associates-in-early-diffuse-cutaneous-systemic-sclerosis-the-european-scleroderma-observational-study
#9
Sébastien Peytrignet, Christopher P Denton, Mark Lunt, Roger Hesselstrand, Luc Mouthon, Alan Silman, Xiaoyan Pan, Edith Brown, László Czirják, Jörg H W Distler, Oliver Distler, Kim Fligelstone, William J Gregory, Rachel Ochiel, Madelon Vonk, Codrina Ancuta, Voon H Ong, Dominique Farge, Marie Hudson, Marco Matucci-Cerinic, Alexandra Balbir-Gurman, Øyvind Midtvedt, Alison C Jordan, Wendy Stevens, Pia Moinzadeh, Frances C Hall, Christian Agard, Marina E Anderson, Elisabeth Diot, Rajan Madhok, Mohammed Akil, Maya H Buch, Lorinda Chung, Nemanja Damjanov, Harsha Gunawardena, Peter Lanyon, Yasmeen Ahmad, Kuntal Chakravarty, Søren Jacobsen, Alexander J MacGregor, Neil McHugh, Ulf Müller-Ladner, Gabriela Riemekasten, Michael Becker, Janet Roddy, Patricia E Carreira, Anne Laure Fauchais, Eric Hachulla, Jennifer Hamilton, Murat Inanç, John S McLaren, Jacob M van Laar, Sanjay Pathare, Susanna Proudman, Anna Rudin, Joanne Sahhar, Brigitte Coppere, Christine Serratrice, Tom Sheeran, Douglas J Veale, Claire Grange, Georges-Selim Trad, Ariane L Herrick
Objectives: Our aim was to describe the burden of early dcSSc in terms of disability, fatigue and pain in the European Scleroderma Observational Study cohort, and to explore associated clinical features. Methods: Patients completed questionnaires at study entry, 12 and 24 months, including the HAQ disability index (HAQ-DI), the Cochin Hand Function Scale (CHFS), the Functional Assessment of Chronic Illness Therapy-fatigue and the Short Form 36 (SF36). Associates examined included the modified Rodnan skin score (mRSS), current digital ulcers and internal organ involvement...
November 30, 2017: Rheumatology
https://www.readbyqxmd.com/read/29202312/bernstein-s-levels-of-movement-construction-a-contemporary-perspective
#10
Vitor L S Profeta, Michael T Turvey
Explanation of how goal-directed movements are made manifest is the ultimate aim of the field classically referred to as "motor control". Essential to the sought-after explanation is comprehension of the supporting functional architecture. Seven decades ago, the Russian physiologist and movement scientist Nikolai A. Bernstein proposed a hierarchical model to explain the construction of movements. In his model, the levels of the hierarchy share a common language (i.e., they are commensurate) and perform complementing functions to bring about dexterous movements...
December 1, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29200367/anesthetic-management-in-mitochondrial-encephalomyopathy-a-case-report
#11
Toru Yamamoto, Noriko Miyazawa, Shinichi Yamamoto, Hiroshi Kawahara
We report on a morbidly obese 16-year-old boy (weight, 116 kg; height, 176 cm; body mass index, 35.5 kg/m2) with mitochondrial encephalomyopathy and a history of cerebral infarction, epilepsy, and severe mental retardation. The patient was scheduled for elective surgery under general anesthesia for multiple dental caries and entropion of the left eye. Preoperative examination results, including an electrocardiogram, were normal. No obvious cardiac function abnormalities were observed on echocardiography. Midazolam (10 mg) was administered orally as premedication 30 minutes before transfer to the operating room; however, the patient was uncooperative, and his body movements were difficult to control upon entering the operating room...
2017: Anesthesia Progress
https://www.readbyqxmd.com/read/29199642/signal-processing-methods-for-reducing-artifacts-in-microelectrode-brain-recordings-caused-by-functional-electrical-stimulation
#12
Daniel Young, Francis Willett, William D Memberg, Brian Murphy, Benjamin Walter, Jennifer A Sweet, Jonathan Miller, Leigh Hochberg, Robert F Kirsch, A Bolu Ajiboye
OBJECTIVE: Functional electrical stimulation (FES) is a promising technology for restoring movement to paralyzed limbs. Intracortical brain-computer interfaces (iBCIs) have enabled intuitive control over virtual and robotic movements, and more recently over upper extremity FES neuroprostheses. However, electrical stimulation of muscles creates artifacts in intracortical microelectrode recordings that could degrade iBCI performance. Here, we investigate methods for reducing the cortically recorded artifacts that result from peripheral electrical stimulation...
December 4, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29199471/outcomes-of-triceps-rupture-in-the-us-military-minimum-2-year-follow-up
#13
John C Dunn, Nicholas Kusnezov, Austin Fares, Kelly Kilcoyne, E'stephan Garcia, Justin D Orr, Brian R Waterman
BACKGROUND: The objective of this study was to examine the subjective and objective midterm functional clinical outcomes of surgically repaired triceps injuries in a moderate- to high-demand population. METHODS: The US Military Health System was queried to identify all surgically treated triceps tendon ruptures between 2008 and 2013. Primary endpoints included rates of rerupture, perioperative complications, or significant persistent elbow dysfunction; Disability of the Arm, Shoulder and Hand (DASH) score, Mayo Elbow score, and ability to do push-ups were also extracted...
December 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29198773/sex-and-age-dependent-differences-in-autonomic-nervous-system-functioning-in-adolescents
#14
Massimiliano de Zambotti, Harold Javitz, Peter L Franzen, Ty Brumback, Duncan B Clark, Ian M Colrain, Fiona C Baker
PURPOSE: We assessed sex- and age-dependent differences in a cross-sectional analysis of cardiac autonomic nervous system (ANS) regulation during sleep in adolescents. METHODS: Nocturnal heart rate (HR) and heart rate variability (HRV) metrics, reflecting ANS functioning, were analyzed across the night and within undisturbed rapid eye movement (REM) and non-REM sleep in 149 healthy adolescents (12-22 years; 67 female) from the National Consortium on Alcohol and Neurodevelopment in Adolescence...
December 1, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29197412/does-motivation-matter-in-upper-limb-rehabilitation-after-stroke-armeosenso-reward-study-protocol-for-a-randomized-controlled-trial
#15
Mario Widmer, Jeremia P Held, Frieder Wittmann, Olivier Lambercy, Kai Lutz, Andreas R Luft
BACKGROUND: Fifty percent of all stroke survivors remain with functional impairments of their upper limb. While there is a need to improve the effectiveness of rehabilitative training, so far no new training approach has proven to be clearly superior to conventional therapy. As training with rewarding feedback has been shown to improve motor learning in humans, it is hypothesized that rehabilitative arm training could be enhanced by rewarding feedback. In this paper, we propose a trial protocol investigating rewards in the form of performance feedback and monetary gains as ways to improve effectiveness of rehabilitative training...
December 2, 2017: Trials
https://www.readbyqxmd.com/read/29194396/aquaporins-during-pregnancy-their-function-and-significance
#16
REVIEW
Eszter Ducza, Adrienn Csányi, Róbert Gáspár
Water is the major component of cells and tissues, and the movement of water across the cell membrane is a fundamental property of life. Until the discovery of the first water channel, aquaporin, it was long assumed that the transport of water was due to simple diffusion through the lipid bilayer membrane that encloses cells. Aquaporin (AQP) molecules were first discovered in the human uterus in 1994, and since then several studies have investigated these channels in the female reproductive system. The expressions of AQPs have been proven in the reproductive system...
December 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29193484/network-dynamics-engaged-in-the-modulation-of-motor-behavior-in-stroke-patients
#17
Eva-Maria Pool, Martha Leimbach, Ellen Binder, Charlotte Nettekoven, Simon B Eickhoff, Gereon R Fink, Christian Grefkes
Stroke patients with motor deficits typically feature enhanced neural activity in several cortical areas when moving their affected hand. However, also healthy subjects may show higher levels of neural activity in tasks with higher motor demands. Therefore, the question arises to what extent stroke-related overactivity reflects performance-level-associated recruitment of neural resources rather than stroke-induced neural reorganization. We here investigated which areas in the lesioned brain enable the flexible adaption to varying motor demands compared to healthy subjects...
November 28, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29192330/the-role-of-ocelli-in-cockroach-optomotor-performance
#18
Anna Honkanen, Paulus Saari, Jouni Takalo, Kyösti Heimonen, Matti Weckström
Insect ocelli are relatively simple eyes that have been assigned various functions not related to pictorial vision. In some species they function as sensors of ambient light intensity, from which information is relayed to various parts of the nervous system, e.g., for the control of circadian rhythms. In this work we have investigated the possibility that the ocellar light stimulation changes the properties of the optomotor performance of the cockroach Periplaneta americana. We used a virtual reality environment where a panoramic moving image is presented to the cockroach while its movements are recorded with a trackball...
November 30, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/29191370/linc-complexes-and-nuclear-positioning
#19
REVIEW
Yin Loon Lee, Brian Burke
One of the characteristics of eukaryotic cells is their structural plasticity associated with the ability to carry out a broad range of complex functions, both autonomously and as components of tissues and organs. Major cellular rearrangements can be observed in various systems from meiosis in fission yeast, through dermal differentiation in nematodes, to muscle and neuronal development in vertebrates. Each of these processes involves oftentimes dramatic relocation of the nucleus within the cell. During the last decade it has become apparent that the nuclear periphery represents a nexus of cytoskeletal interactions that are involved not only in nuclear movement but also in the distribution and dissemination of mechanical forces throughout the cell...
November 27, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29186964/yeast-two-hybrid-and-pull-down-assays-propose-an-interaction-between-p50-of-apple-chlorotic-leaf-spot-virus-and-pr-10-of-malus-sylvestris-cv-r12740-7a
#20
Y Wang, N Li, X Zhao, J Hu, Y He, T Hu, S Wang, Y Wang, K Cao
Apple chlorotic leaf spot virus (ACLSV) movement protein (P50) is involved in cell-to-cell transport and influences the long-distance spread of silencing activity. Previously, we obtained 69 P50-interacting proteins from Malus sylvestris cv. R12740-7A and using bioinformatics analyzed their biological functions. In this study, we used the GAL4-based two-hybrid yeast system and His pull-down assays to confirm an interaction between PR-10 of M. sylvestris cv. R12740-7A and ACLSV P50. Our results provide a theoretical basis for further research on the biological function of PR-10 in ACLSV infection and the interacting mechanism between host and virus...
2017: Acta Virologica
keyword
keyword
96960
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"