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Functional Movement Systems

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https://www.readbyqxmd.com/read/27922659/eye-movement-analysis-and-cognitive-assessment-the-use-of-comparative-visual-search-tasks-in-a-non-immersive-vr-application
#1
Pedro J Rosa, Pedro Gamito, Jorge Oliveira, Diogo Morais, Matthew Pavlovic, Olivia Smyth, Inês Maia, Tiago Gomes
BACKGROUND: An adequate behavioral response depends on attentional and mnesic processes. When these basic cognitive functions are impaired, the use of non-immersive Virtual Reality Applications (VRAs) can be a reliable technique for assessing the level of impairment. However, most non-immersive VRAs use indirect measures to make inferences about visual attention and mnesic processes (e.g., time to task completion, error rate). OBJECTIVES: To examine whether the eye movement analysis through eye tracking (ET) can be a reliable method to probe more effectively where and how attention is deployed and how it is linked with visual working memory during comparative visual search tasks (CVSTs) in non-immersive VRAs...
December 6, 2016: Methods of Information in Medicine
https://www.readbyqxmd.com/read/27918704/comparison-of-3d-joint-angles-measured-with-the-kinect-2-0-skeletal-tracker-versus-a-marker-based-motion-capture-system
#2
Trent M Guess, Swithin Razu, Amirhossein Jahandar, Marjorie Skubic, Zhiyu Huo
The Microsoft Kinect is becoming a widely used tool for inexpensive, portable measurement of human motion with the potential to support clinical assessments of performance and function. In this study, the relative osteokinematic Cardan joint angles of the hip and knee were calculated using the Kinect 2.0 skeletal tracker. The pelvis segments of the default skeletal model were reoriented and three-dimensional joint angles were compared to a marker-based system during a drop vertical jump and a hip abduction motion...
December 5, 2016: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/27917451/reversal-learning-reveals-cognitive-deficits-and-altered-prediction-error-encoding-in-the-ventral-striatum-in-huntington-s-disease
#3
Katharina Nickchen, Rebecca Boehme, Maria Del Mar Amador, Thomas D Hälbig, Katharina Dehnicke, Patricia Panneck, Joachim Behr, Konstantin Prass, Andreas Heinz, Lorenz Deserno, Florian Schlagenhauf, Josef Priller
Huntington's disease (HD) is an autosomal dominant neurodegenerative condition characterized by a triad of movement disorder, neuropsychiatric symptoms and cognitive deficits. The striatum is particularly vulnerable to the effects of mutant huntingtin, and cell loss can already be found in presymptomatic stages. Since the striatum is well known for its role in reinforcement learning, we hypothesized to find altered behavioral and neural responses in HD patients in a probabilistic reinforcement learning task performed during functional magnetic resonance imaging...
December 5, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27913783/three-dimensional-printed-prosthesis-demonstrates-functional-improvement-in-a-patient-with-an-amputated-thumb-a-technical-note
#4
Keun Ho Lee, Sung Jae Kim, Yong Ho Cha, Jae Lim Kim, Dong Kyu Kim, Sang Jun Kim
BACKGROUND AND AIM: Three-dimensional printer is widely used in industry, biology, and medical fields. We report a finger prosthesis produced by a three-dimensional scanner and printer for a 67-year-old man with a right thumb amputation above the metacarpophalangeal joint. TECHNIQUE: His right amputated and left intact hands were scanned with a three-dimensional scanner, and the left-hand image was rotated to the right side to design the right thumb prosthesis. The designed prosthesis was printed with a three-dimensional printer using the fused filament fabrication output system...
December 1, 2016: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/27913430/cortical-circuit-for-binding-object-identity-and-location-during-multiple-object-tracking
#5
Lauri Nummenmaa, Lauri Oksama, Erico Glerean, Jukka Hyönä
Sustained multifocal attention for moving targets requires binding object identities with their locations. The brain mechanisms of identity-location binding during attentive tracking have remained unresolved. In 2 functional magnetic resonance imaging experiments, we measured participants' hemodynamic activity during attentive tracking of multiple objects with equivalent (multiple-object tracking) versus distinct (multiple identity tracking, MIT) identities. Task load was manipulated parametrically. Both tasks activated large frontoparietal circuits...
December 1, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27909646/the-neural-mechanisms-of-meditative-practices-novel-approaches-for-healthy-aging
#6
REVIEW
Bianca P Acevedo, Sarah Pospos, Helen Lavretsky
OBJECTIVES: Meditation has been shown to have physical, cognitive, and psychological health benefits that can be used to promote healthy aging. However, the common and specific mechanisms of response remain elusive due to the diverse nature of mind-body practices. METHODS: In this review, we aim to compare the neural circuits implicated in focused-attention meditative practices that focus on present-moment awareness to those involved in active-type meditative practices (e...
2016: Current Behavioral Neuroscience Reports
https://www.readbyqxmd.com/read/27908173/pacemaker-and-icd-oversensing-induced-by-movements-near-the-mri-scanner-bore
#7
E Mattei, F Censi, G Calcagnini, R Falsaperla, E Genovese, A Napolitano, V Cannatà
PURPOSE: The effect of the movement near the MRI scanner bore for people with a pacemaker (PM) or an implantable cardioverter defibrillator (ICD) is experimentally evaluated and discussed. METHODS: The authors performed in vitro measurements on a saline-filled human-shaped phantom (male, 170 cm height), equipped first with an MR-conditional PM (bicameral configuration, DDD programming), then with an MR-conditional ICD (biventricular configuration, detection algorithms enable but shock delivery disable)...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27906389/emulation-of-synaptic-metaplasticity-in-memristors
#8
Xiaojian Zhu, Chao Du, YeonJoo Jeong, Wei D Lu
Recent studies have shown that nanoionic-based memristors can offer rich internal dynamics during ion movement that enables these solid-state devices to emulate various synaptic functions in biological systems naturally. The experimental observations can be explained within the 2nd-order memristor theoretical framework, which states that the device conductance (weight) can be determined by multiple internal state variables that can be modulated at different time scales and lead to different activity-dependent synaptic behaviors...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27906103/progressive-impairment-of-cav1-1-function-in-the-skeletal-muscle-of-mice-expressing-a-mutant-type-1-cu-zn-superoxide-dismutase-g93a-linked-to-amyotrophic-lateral-sclerosis
#9
Donald Beqollari, Christin F Romberg, Gabriella Dobrowolny, Martina Martini, Andrew A Voss, Antonio Musarò, Roger A Bannister
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder that is typically fatal within 3-5 years of diagnosis. While motoneuron death is the defining characteristic of ALS, the events that underlie its pathology are not restricted to the nervous system. In this regard, ALS muscle atrophies and weakens significantly before presentation of neurological symptoms. Since the skeletal muscle L-type Ca(2+) channel (CaV1.1) is a key regulator of both mass and force, we investigated whether CaV1...
June 23, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27903293/personalized-medicine-approach-confirms-a-milder-case-of-abat-deficiency
#10
A Besse, A K Petersen, J V Hunter, V Appadurai, S R Lalani, P E Bonnen
ABAT deficiency (OMIM 613163) is a rare inborn error of metabolism caused by recessive variants in the gene 4-aminobutyric acid transaminase (ABAT), which is responsible for both the catalysis of GABA and maintenance of nucleoside pools in the mitochondria. To date, only a few patients have been reported worldwide. Their clinical presentation has been remarkably consistent with primary features of severe psychomotor retardation, encephalopathy, hypotonia, and infantile-onset refractory epilepsy. We report a new case of ABAT deficiency that marks an important departure from previous clinical findings...
December 1, 2016: Molecular Brain
https://www.readbyqxmd.com/read/27902697/a-novel-zebrafish-ret-heterozygous-model-of-hirschsprung-disease-identifies-a-functional-role-for-mapk10-as-a-modifier-of-enteric-nervous-system-phenotype-severity
#11
Tiffany A Heanue, Werend Boesmans, Donald M Bell, Koichi Kawakami, Pieter Vanden Berghe, Vassilis Pachnis
Hirschsprung disease (HSCR) is characterized by absence of enteric neurons from the distal colon and severe intestinal dysmotility. To understand the pathophysiology and genetics of HSCR we developed a unique zebrafish model that allows combined genetic, developmental and in vivo physiological studies. We show that ret mutant zebrafish exhibit cellular, physiological and genetic features of HSCR, including absence of intestinal neurons, reduced peristalsis, and varying phenotype expressivity in the heterozygous state...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27902342/functional-analysis-of-a-viroid-rna-motif-mediating-cell-to-cell-movement-in-nicotiana-benthamiana
#12
Dongmei Jiang, Meng Wang, Shifang Li
Cell-to-cell trafficking through different cellular layers is a key process for various RNAs including those of plant viruses and viroids, but the regulatory mechanisms involved are still not fully elucidated and good model systems are important. Here, we analyze the function of a simple RNA motif (termed "loop19") in Potato spindle tuber viroid (PSTVd) which is required for trafficking in Nicotiana benthamiana leaves. Northern blotting, RT-PCR and in situ hybridization analyses demonstrated that unlike wild type PSTVd, which was present in the nuclei in all cell types, the trafficking-defective loop19 mutants were visible only in the nuclei of upper epidermal and palisade mesophyll cells, which shows that PSTVd loop19 plays a role in mediating RNA trafficking from palisade to spongy mesophyll cells in Nicotiana benthamiana leaves...
October 14, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27901100/imaging-analysis-of-parkinson-s-disease-patients-using-spect-and-tractography
#13
Seong-Jin Son, Mansu Kim, Hyunjin Park
Parkinson's disease (PD) is a degenerative disorder that affects the central nervous system. PD-related alterations in structural and functional neuroimaging have not been fully explored. This study explored multi-modal PD neuroimaging and its application for predicting clinical scores on the Movement Disorder Society-sponsored Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Multi-modal imaging that combined (123)I-Ioflupane single-photon emission computed tomography (SPECT) and diffusion tensor imaging (DTI) were adopted to incorporate complementary brain imaging information...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900947/continuous-decoding-of-human-grasp-kinematics-using-epidural-and-subdural-signals
#14
Robert D Flint, Joshua M Rosenow, Matthew C Tate, Marc W Slutzky
OBJECTIVE: Restoring or replacing function in paralyzed individuals will one day be achieved through the use of brain-machine interfaces. Regaining hand function is a major goal for paralyzed patients. Two competing prerequisites for the widespread adoption of any hand neuroprosthesis are accurate control over the fine details of movement, and minimized invasiveness. Here, we explore the interplay between these two goals by comparing our ability to decode hand movements with subdural and epidural field potentials (EFPs)...
November 30, 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27899087/paradoxical-physiological-responses-to-propranolol-in-a-rett-syndrome-patient-a-case-report
#15
P J Santosh, L Bell, K Lievesley, J Singh, F Fiori
BACKGROUND: Rett Syndrome (RTT), caused by a loss-of-function in the epigenetic modulator: X-linked methyl-CpG binding protein 2 (MeCP2), is a pervasive neurological disorder characterized by compromised brain functions, anxiety, severe mental retardation, language and learning disabilities, repetitive stereotyped hand movements and developmental regression. An imbalance in the sympathetic and the parasympathetic nervous system (dysautonomia) and the resulting autonomic storms is a frequent occurrence in patients with RTT...
November 29, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27898852/horse-species-symposium-biomechanics-of-the-exercising-horse
#16
Hilary M Clayton
In spite of having large height and body mass, horses are cursorial animals with an extensive gait repertoire and considerable athletic abilities. The limbs have evolved so that the heavy musculature is confined to the proximal limbs while the distal limbs are light in weight with a single functional digit and long, lightweight tendons to move and support the distal joints. These adaptations reduce the moment of inertia and decrease the energy expended to protract and retract the limbs during locomotion. There is a division of labor between the forelimbs, which have a pillar-like construction specialized for weight bearing, and the hind limbs, in which the more angulated joints provide leverage for the generation of propulsion...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27897203/reducing-gabaa-mediated-inhibition-improves-forelimb-motor-function-after-focal-cortical-stroke-in-mice
#17
Claudia Alia, Cristina Spalletti, Stefano Lai, Alessandro Panarese, Silvestro Micera, Matteo Caleo
A deeper understanding of post-stroke plasticity is critical to devise more effective pharmacological and rehabilitative treatments. The GABAergic system is one of the key modulators of neuronal plasticity, and plays an important role in the control of "critical periods" during brain development. Here, we report a key role for GABAergic inhibition in functional restoration following ischemia in the adult mouse forelimb motor cortex. After stroke, the majority of cortical sites in peri-infarct areas evoked simultaneous movements of forelimb, hindlimb and tail, consistent with a loss of inhibitory signalling...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27894611/the-threshold-theory-for-parkinson-s-disease
#18
REVIEW
Simone Engelender, Ole Isacson
Parkinson's disease (PD) is recognized by the accumulation of α-synuclein within neurons. In contrast to the current ascending theory where α-synuclein would propagate from neuron to neuron, we now propose the threshold theory for PD based on evidence of parallel degeneration of both central nervous system (CNS) and peripheral nervous system (PNS) in PD. The functional threshold is lower for the emergence of early symptoms before the classical motor symptoms of PD. This is due to the larger functional reserve of the midbrain dopamine and integrated basal ganglia motor systems to control movement...
November 25, 2016: Trends in Neurosciences
https://www.readbyqxmd.com/read/27894024/foot-placement-during-error-and-pedal-applications-in-naturalistic-driving
#19
Yuqing Wu, Linda Ng Boyle, Daniel McGehee, Cheryl A Roe, Kazutoshi Ebe, James Foley
Data from a naturalistic driving study was used to examine foot placement during routine foot pedal movements and possible pedal misapplications. The study included four weeks of observations from 30 drivers, where pedal responses were recorded and categorized. The foot movements associated with pedal misapplications and errors were the focus of the analyses. A random forest algorithm was used to predict the pedal application types based the video observations, foot placements, drivers' characteristics, drivers' cognitive function levels and anthropometric measurements...
November 25, 2016: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27893991/saclab-a-toolbox-for-saccade-analysis-to-increase-usability-of-eye-tracking-systems-in-clinical-ophthalmology-practice
#20
Laura Cercenelli, Guido Tiberi, Ivan Corazza, Giuseppe Giannaccare, Michela Fresina, Emanuela Marcelli
PURPOSE: Many open source software packages have been recently developed to expand the usability of eye tracking systems to study oculomotor behavior, but none of these is specifically designed to encompass all the main functions required for creating eye tracking tests and for providing the automatic analysis of saccadic eye movements. The aim of this study is to introduce SacLab, an intuitive, freely-available MATLAB toolbox based on Graphical User Interfaces (GUIs) that we have developed to increase the usability of the ViewPoint EyeTracker (Arrington Research, Scottsdale, AZ, USA) in clinical ophthalmology practice...
November 22, 2016: Computers in Biology and Medicine
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