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https://www.readbyqxmd.com/read/29331774/the-synergy-of-vitamin-c-with-decitabine-activates-tet2-in-leukemic-cells-and-significantly-improves-overall-survival-in-elderly-patients-with-acute-myeloid-leukemia
#1
Huihui Zhao, Huayuan Zhu, Jiayu Huang, Yu Zhu, Ming Hong, Han Zhu, Jingjing Zhang, Shan Li, Lijia Yang, Yun Lian, Shuai Wang, Jianping Mao, Yaoyu Chen, Jianyong Li, Sixuan Qian
BACKGROUND: Decitabine is widely used in the treatment of acute myeloid leukemia (AML) in elderly patients. Low-dose Vitamin C has also been indicated to induce DNA demethylation at the cellular level. However, little is known whether low-dose Vitamin C has a synergistic effect with decitabine in clinic. METHODS: The effect of combined low-dose Vitamin C and decitabine on cell proliferation, the cell cycle, apoptosis and the expression level and activity of TET2 was investigated in HL60 and NB4 human leukemic cells...
January 2, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29331763/inhibition-of-isoprenylcysteine-carboxylmethyltransferase-sensitizes-common-chemotherapies-in-cervical-cancer-via-ras-dependent-pathway
#2
Qin Pan, Rong Liu, Hasina Banu, Liang Ma, Hui Li
Isoprenylcysteine carboxylmethyltransferase (Icmt) catalyzes the last step of post-translational protein prenylation, which is essential for the stability and proper functions of many oncogenic proteins, such as Ras. Despite extensive studies on the roles of Icmt in tumor transformation and progression, little is known on the involvement ofIcmt in the development of tumor resistance to chemotherapy. Here we show the upregulation of Icmt as a persistent response to chemotherapy in cervical cancer cells. In-depth functional analysis demonstrated that Icmt inhibition significantly inhibited growth, induced apoptosis and augmented the inhibitory effects of chemotherapy drugs in cervical cancer in cell culture system and xenograft mouse model...
January 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29330467/evidence-for-sparse-synergies-in-grasping-actions
#3
Roberto Prevete, Francesco Donnarumma, Andrea d'Avella, Giovanni Pezzulo
Converging evidence shows that hand-actions are controlled at the level of synergies and not single muscles. One intriguing aspect of synergy-based action-representation is that it may be intrinsically sparse and the same synergies can be shared across several distinct types of hand-actions. Here, adopting a normative angle, we consider three hypotheses for hand-action optimal-control: sparse-combination hypothesis (SC) - sparsity in the mapping between synergies and actions - i.e., actions implemented using a sparse combination of synergies; sparse-elements hypothesis (SE) - sparsity in synergy representation - i...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29324751/stage-specific-ifn-induced-and-ifn-gene-expression-reveal-convergence-of-type-i-and-type-ii-ifn-and-highlight-their-role-in-both-acute-and-chronic-stage-of-pathogenic-siv-infection
#4
Nadia Echebli, Nicolas Tchitchek, Stéphanie Dupuy, Timothée Bruel, Caroline Peireira Bittencourt Passaes, Nathalie Bosquet, Roger Le Grand, Christine Bourgeois, Benoit Favier, Rémi Cheynier, Olivier Lambotte, Bruno Vaslin
Interferons (IFNs) play a major role in controlling viral infections including HIV/SIV infections. Persistent up-regulation of interferon stimulated genes (ISGs) is associated with chronic immune activation and progression in SIV/HIV infections, but the respective contribution of different IFNs is unclear. We analyzed the expression of IFN genes and ISGs in tissues of SIV infected macaques to understand the respective roles of type I and type II IFNs. Both IFN types were induced in lymph nodes during early stage of primary infection and to some extent in rectal biopsies but not in PBMCs...
2018: PloS One
https://www.readbyqxmd.com/read/29321678/systems-pharmacology-analysis-of-synergy-of-tcm-an-example-using-saffron-formula
#5
Jianling Liu, Jingjing Liu, Fengxia Shen, Zonghui Qin, Meng Jiang, Jinglin Zhu, Zhenzhong Wang, Jun Zhou, Yingxue Fu, Xuetong Chen, Chao Huang, Wei Xiao, Chunli Zheng, Yonghua Wang
Traditional Chinese medicine (TCM) follows the principle of formulae, in which the pharmacological activity of a single herb can be enhanced or potentiated by addition of other herbs. Nevertheless, the involved synergy mechanisms in formulae remain unknown. Here, a systems-based method is proposed and applied to three representative Chinese medicines in compound saffron formula (CSF): two animal spices (Moschus, Beaver Castoreum), and one herb Crocus sativus which exert synergistic effects for cardiovascular diseases (CVDs)...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320578/the-potent-effect-of-mycolactone-on-lipid-membranes
#6
Milène Nitenberg, Anaïs Bénarouche, Ofelia Maniti, Estelle Marion, Laurent Marsollier, Julie Géan, Erick J Dufourc, Jean-François Cavalier, Stéphane Canaan, Agnès P Girard-Egrot
Mycolactone is a lipid-like endotoxin synthesized by an environmental human pathogen, Mycobacterium ulcerans, the causal agent of Buruli ulcer disease. Mycolactone has pleiotropic effects on fundamental cellular processes (cell adhesion, cell death and inflammation). Various cellular targets of mycolactone have been identified and a literature survey revealed that most of these targets are membrane receptors residing in ordered plasma membrane nanodomains, within which their functionalities can be modulated...
January 10, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29319092/synthesis-of-u-channelled-spherical-fex-coyni1-y-100-x-janus-colloidal-particles-with-excellent-electromagnetic-wave-absorption-performance
#7
Hao Li, Zhenming Cao, Jiayao Lin, Hui Zhao, Qiaorong Jiang, Zhiyuan Jiang, Honggang Liao, Qin Kuang, Zhaoxiong Xie
Due to their distinctive structure, inherently anisotropic properties and broad applications, Janus colloidal particles have attracted tremendous attention and it is significant to synthesize high yield Janus colloidal particles in a cost-effective and reliable way. On the other hand, due to the expanded electromagnetic interference problems, it is highly desired to develop excellent electromagnetic wave absorbing materials with an ultra-wide absorption bandwidth for practical application. Herein, a confined liquid-solid redox reaction strategy has been developed to fabricate a series of Fex(CoyNi1-y)100-x ternary alloy particles...
January 10, 2018: Nanoscale
https://www.readbyqxmd.com/read/29318196/engineered-polyketides-synergy-between-protein-and-host-level-engineering
#8
REVIEW
Jesus F Barajas, Jacquelyn M Blake-Hedges, Constance B Bailey, Samuel Curran, Jay D Keasling
Metabolic engineering efforts toward rewiring metabolism of cells to produce new compounds often require the utilization of non-native enzymatic machinery that is capable of producing a broad range of chemical functionalities. Polyketides encompass one of the largest classes of chemically diverse natural products. With thousands of known polyketides, modular polyketide synthases (PKSs) share a particularly attractive biosynthetic logic for generating chemical diversity. The engineering of modular PKSs could open access to the deliberate production of both existing and novel compounds...
September 2017: Synthetic and Systems Biotechnology
https://www.readbyqxmd.com/read/29317454/casein-kinase-1-is-a-therapeutic-target-in-chronic-lymphocytic-leukemia
#9
Pavlina Janovska, Jan Verner, Jiri Kohoutek, Lenka Bryjova, Michaela Gregorova, Marta Dzimkova, Hana Skabrahova, Tomasz Radaszkiewicz, Petra Ovesna, Olga Vondalova Blanarova, Tereza Nemcova, Zuzana Hoferova, Katerina Vasickova, Lucie Smyckova, Alexander Egle, Sarka Pavlova, Lucie Poppova, Karla Plevova, Sarka Pospisilova, Vitezslav Bryja
Casein kinase (CK) 1δ/ε is a key component of non-canonical Wnt signaling pathways, which were shown previously to drive pathogenesis of chronic lymphocytic leukemia (CLL). In this study we investigated thoroughly the effects of CK1δ/ε inhibition on the primary CLL cells and analyzed the therapeutic potential in vivo using two murine model systems based on the Eµ-TCL1-induced leukemia (syngeneic adoptive transfer model and spontaneous disease development), which resemble closely the human CLL. We can demonstrate that CK1δ/ε inhibitor PF-670462 significantly blocks microenvironmental interactions - chemotaxis, invasion and communication with stromal cells in primary CLL cells in all major subtypes of CLL...
January 9, 2018: Blood
https://www.readbyqxmd.com/read/29317432/in-silico-evaluation-of-pharmacokinetic-optimization-for-antimitogram-based-clinical-trials
#10
Skerdi Haviari, Benoît You, Michel Tod
Antimitograms are prototype in vitro tests for evaluating chemotherapeutic efficacy using patient-derived primary cancer cells. These tests might help optimize treatment from a pharmacodynamic (PD) standpoint by guiding treatment selection. However, they are technically challenging and require refinements and trials to demonstrate benefit in order to be widely used. In this study, we performed simulations aimed at exploring how to validate antimitograms and how to complement them by pharmacokinetic (PK) optimization...
January 9, 2018: Cancer Research
https://www.readbyqxmd.com/read/29316499/electrochemical-study-of-enhanced-nitrate-removal-in-wastewater-treatment-using-biofilm-electrode
#11
Xuan Jiang, Diwen Ying, Dian Ye, Runqiu Zhang, Qingbin Guo, Yalin Wang, Jinping Jia
Bioelectrochemical enhanced nitrate removal in wastewater with high total nitrogen and low organic carbon was electrochemically investigated focusing on the relationship between biochemical and electrochemical nitrogen cycles. Under optimized external voltage of -0.6 V, apparent nitrate removal rate of bioelectrochemical denitrification was 76% higher than normal biofilm denitrification. And with the introduction of biofilm on the electrode, new reduction peak of N2O, much larger current density, and 0.4 V positively shift of on-set potential of nitrate reduction reaction were observed, suggesting a synergy of electrochemical reaction and biological reaction through enhanced electrochemical reduction of intermediate products from biological process...
December 26, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29315914/coupling-mechanical-and-electrical-properties-in-spin-crossover-polymer-composites
#12
Sylvain Rat, Mario Piedrahita-Bello, Lionel Salmon, Gábor Molnár, Philippe Demont, Azzedine Bousseksou
Spin crossover particles of formula [Fe{(Htrz)2 (trz)}0.9 (NH2 -trz)0.3 ](BF4 )1.1 and average size of 20 nm ± 8 nm are homogeneously dispersed in poly(vinylidene fluoride-co-trifluoro-ethylene), P(VDF-TrFE), and poly(vinylidene fluoride) (PVDF) matrices to form macroscopic (cm-scale), freestanding, and flexible nanocomposite materials. The composites exhibit concomitant thermal expansion and discharge current peaks on cycling around the spin transition temperatures, i.e., new "product properties" resulting from the synergy between the particles and the matrix...
January 8, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29313497/digital-health-and-the-need-to-develop-centers-of-expertise-in-sub-saharan-africa%C3%A2-two-examples-in-mali-and-cameroon
#13
C-O Bagayoko, G Bediang, A Anne, M Niang, A-K Traoré, A Geissbuhler
It is generally agreed today that digital technology provides a lever for improving access to health care, care processes, and public health planning and activities such as education and prevention. Its use in countries that have reached a given level of development has taken place in a somewhat fragmented manner that raises important interoperability problems and sometimes makes synergy impossible between the different projects of digital health. This may be linked to several factors, principally the lack of a global vision of digital health, and inadequate methodological knowledge that prevents the development and implementation of this vision...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29313079/comprehensive-characterization-of-neurochemicals-in-three-zebrafish-chemical-models-of-human-acute-organophosphorus-poisoning-using-liquid-chromatography-tandem-mass-spectrometry
#14
Cristian Gómez-Canela, Daniel Tornero-Cañadas, Eva Prats, Benjamí Piña, Romà Tauler, Demetrio Raldúa
There is a growing interest in biological models to investigate the effect of neurotransmitter dysregulation on the structure and function of the central nervous system (CNS) at different stages of development. Zebrafish, a vertebrate model increasingly used in neurobiology and neurotoxicology, shares the common neurotransmitter systems with mammals, including glutamate, GABA, glycine, dopamine, norepinephrine, epinephrine, serotonin, acetylcholine, and histamine. In this study, we have evaluated the performance of liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the multiresidue determination of neurotransmitters and related metabolites...
January 9, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29313067/combinatorial-effects-of-histone-deacetylase-inhibitors-hdaci-vorinostat-and-entinostat-and-adaphostin-are-characterized-by-distinct-redox-alterations
#15
Nilsa Rivera-Del Valle, Tiewei Cheng, Mary E Irwin, Hayley Donnella, Melissa M Singh, Joya Chandra
PURPOSE: Amongst the epigenetically targeted therapies, targeting of the histone deacetylases (HDACs) has yielded numerous drugs for clinical use in hematological malignancies, but none as yet for acute lymphocytic leukemia (ALL). Single agent activity of HDAC inhibitors (HDACi) has been elusive in ALL, and has prompted study of combinatorial strategies. Because several HDACi raise levels of intracellular oxidative stress, we evaluated combinations of two structurally distinct HDACi with the redox active compound adaphostin in ALL...
January 8, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29313050/ultrafine-pto2-nanoparticles-coupled-with-a-co-oh-f-nanowire-array-for-enhanced-hydrogen-evolution
#16
Ziqiang Wang, Zhiang Liu, Gu Du, Abdullah M Asiri, Liang Wang, Xiaonian Li, Hongjing Wang, Xuping Sun, Liang Chen, Qiuju Zhang
In this communication, we report the in situ formation of ultrafine PtO2 nanoparticles coupled with a Co(OH)F nanowire array (PtO2-Co(OH)F NA/TM) via a facile hydrothermal treatment. The PtO2-Co(OH)F NA/TM possesses interfacial synergy derived from its favorable composition and structure. It can greatly promote water dissociation and optimize the free energy of H* adsorption, indicating high catalytic activity towards the alkaline HER.
January 9, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29311287/comparison-of-a-simple-angiographic-approach-with-a-synergy-between-percutaneous-coronary-intervention-with-taxus-and-cardiac-surgery-score-based-approach-for-left-main-coronary-artery-stenting-a-pooled-analysis-of-serial-precombat-premier-of-randomized-comparison
#17
Pil Hyung Lee, Jong-Young Lee, Cheol Whan Lee, Seon-Ok Kim, Jung-Min Ahn, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Seong-Wook Park, Seung-Jung Park
BACKGROUND: The applicability of Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery scores to left main coronary artery disease (CAD) has been questioned. A simplified alternative is needed for guiding decision making. METHODS AND RESULTS: We evaluated the prognostic value of a simplified angiographic classification in comparison with a Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery score-based approach for patients with left main CAD undergoing drug-eluting stent implantation...
January 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29310455/association-between-serum-ldl-c-and-apob-and-syntax-score-in-patients-with-stable-coronary-artery-disease
#18
Taiwu Lin, Luzhao Wang, Jingbin Guo, Peng Liu, Liheng Chen, Mengqiu Wei, Gongxin Li
The aim of this study was to examine the relationship between low-density lipoprotein cholesterol (LDL-C) and apolipoprotein (Apo) B levels and the SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery (SYNTAX) score (SS) in patients with stable angina pectoris. We enrolled 594 patients who were suspected to have coronary heart disease (CHD) and who underwent coronary angiography. Patients were divided into 4 groups based on the SS: normal (SS = 0, n = 154), low SS (SS ≤ 22, n = 210), intermediate SS (22 < SS < 32, n = 122), and high SS (SS ≥ 33, n = 63)...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29306874/a-structurally-dynamic-n-terminal-region-drives-function-of-the-staphylococcal-peroxidase-inhibitor-spin
#19
Nienke W M de Jong, Nicoleta T Ploscariu, Kasra X Ramyar, Brandon L Garcia, Alvaro I Herrera, Om Prakash, Benjamin B Katz, Kevin G Leidal, William Nauseef, Kok van Kessel, Jos van Strijp, Brian V Geisbrecht
The heme-containing enzyme myeloperoxidase (MPO) is critical for optimal antimicrobial activity of human neutrophils. We recently discovered that the bacterium Staphylococcus aureus expresses a novel immune evasion protein, called SPIN, that binds tightly to MPO, inhibits MPO activity, and contributes to bacterial survival following phagocytosis. A co-crystal structure of SPIN bound to MPO suggested that SPIN blocks substrate access to the catalytic heme by inserting an N-terminal β-hairpin into the MPO active site channel...
January 5, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29305985/mechanistic-studies-of-the-antibiofilm-activity-and-synergy-with-antibiotics-of-isosorbide-mononitrate
#20
Sayeed Hasan, Yassamin N S Albayaty, Benjamin Thierry, Clive A Prestidge, Nicky Thomas
The use of nitric oxide (NO), a naturally occurring antimicrobial agent, as an alternative strategy to combat bacterial biofilms has recently gained considerable momentum in light of the global threat of emerging antibiotic resistance. While previous NO-based anti-biofilm approaches were aimed at killing bacteria cells within biofilms, NO has also been recently identified as a key mediator of biofilm dispersal, causing the release of cells from the biofilm community. This is of great interest towards the design of more effective anti-biofilm strategies but further studies are warranted to validate this concept...
January 3, 2018: European Journal of Pharmaceutical Sciences
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