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https://www.readbyqxmd.com/read/28231049/original-research-paper-hydrazinyldiene-chroman-2-4-diones-in-inducing-growth-arrest-and-apoptosis-in-breast-cancer-cells-synergism-with-doxorubicin-and-correlation-with-physicochemical-properties
#1
Lulzime Ballazhi, Faik Imeri, Ahmed Jashari, Emil Popovski, Goran Stojković, Aleksandar J Dimovski, Bozhana Mikhova, Kristina Mladenovska
This study evaluates the effects of previously synthesized hydrazinyldiene-chroman-2,4-diones on cell proliferation and apoptosis, cell cycle distribution and migration capacity of MCF-7 breast cancer cells in synergy with doxorubicin. Physicochemical properties of the synthesized compounds were correlated with their structure and activity. Significant cell viability decrease in comparison with the effect of doxorubicin alone and the reference 4-hydroxycoumarin was observed when combination treatment comprising doxorubicin and the title compounds was applied...
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28230847/building-better-biomarkers-brain-models-in-translational-neuroimaging
#2
REVIEW
Choong-Wan Woo, Luke J Chang, Martin A Lindquist, Tor D Wager
Despite its great promise, neuroimaging has yet to substantially impact clinical practice and public health. However, a developing synergy between emerging analysis techniques and data-sharing initiatives has the potential to transform the role of neuroimaging in clinical applications. We review the state of translational neuroimaging and outline an approach to developing brain signatures that can be shared, tested in multiple contexts and applied in clinical settings. The approach rests on three pillars: (i) the use of multivariate pattern-recognition techniques to develop brain signatures for clinical outcomes and relevant mental processes; (ii) assessment and optimization of their diagnostic value; and (iii) a program of broad exploration followed by increasingly rigorous assessment of generalizability across samples, research contexts and populations...
February 23, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28230265/spatial-optimization-of-future-urban-development-with-regards-to-climate-risk-and-sustainability-objectives
#3
Daniel Caparros-Midwood, Stuart Barr, Richard Dawson
Future development in cities needs to manage increasing populations, climate-related risks, and sustainable development objectives such as reducing greenhouse gas emissions. Planners therefore face a challenge of multidimensional, spatial optimization in order to balance potential tradeoffs and maximize synergies between risks and other objectives. To address this, a spatial optimization framework has been developed. This uses a spatially implemented genetic algorithm to generate a set of Pareto-optimal results that provide planners with the best set of trade-off spatial plans for six risk and sustainability objectives: (i) minimize heat risks, (ii) minimize flooding risks, (iii) minimize transport travel costs to minimize associated emissions, (iv) maximize brownfield development, (v) minimize urban sprawl, and (vi) prevent development of greenspace...
February 23, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28229306/behavioral-and-social-sciences-at-the-national-institutes-of-health-adoption-of-research-findings-in-health-research-and-practice-as-a-scientific-priority
#4
William T Riley
The National Institutes of Health's Office of Behavioral and Social Sciences Research (OBSSR) recently released its Strategic Plan for 2017 to 2021. This plan highlights three scientific priorities: (1) improve the synergy of basic and applied behavioral and social sciences research, (2) enhance and promote the research infrastructure, methods, and measures needed to support a more cumulative and integrated approach to behavioral and social sciences research, and (3) facilitate the adoption of behavioral and social sciences research findings in health research and in practice...
February 22, 2017: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/28229206/aos28d-a-proline-xaa-carboxypeptidase-secreted-by-aspergillus-oryzae
#5
Karine Salamin, Philippe J Eugster, Olivier Jousson, Patrice Waridel, Eric Grouzmann, Michel Monod
Prolyl peptidases of the MEROPS S28 family are of particular interest because they are key enzymes in the digestion of proline-rich peptides. A BLAST analysis of the Aspergillus oryzae genome revealed sequences coding for four proteases of the S28 family. Three of these proteases, AoS28A, AoS28B, and AoS28C, were previously characterized as acidic prolyl endopeptidases. The fourth protease, AoS28D, showed high sequence divergence with other S28 proteases and belongs to a phylogenetically distinct cluster together with orthologous proteases from other Aspergillus species...
February 22, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28228745/amnesia-associated-with-bilateral-hippocampal-and-bilateral-basal-ganglia-lesions-in-anoxia-with-stimulant-use
#6
Marc W Haut, Jeffery P Hogg, Patrick J Marshalek, Blair C Suter, Liv E Miller
We report a case of a 55-year-old man with ischemic lesions of the bilateral hippocampus and bilateral basal ganglia following a myocardial infarction during an episode of multiple drug use with subsequent anoxia requiring resuscitation. He presented for a neuropsychological evaluation with an anterograde amnesia for both explicit and procedural memory. There are two main points to this case, the unique aspects of the bilateral multifocal lesions and the functional, cognitive impact of these lesions. We hypothesize that his rare focal bilateral lesions of both the hippocampus and basal ganglia are a result of anoxia acting in synergy with his stimulant drug use (cocaine and/or 3,4-methylenedioxy-methamphetamine)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28228582/multi-digit-force-control-during-unconstrained-grasping-in-response-to-object-perturbations
#7
Abdeldjallil Naceri, Alessandro Moscatelli, Robert Haschke, Helge Ritter, Marco Santello, Marc O Ernst
Because of the complex anatomy of the human hand, in the absence of external constraints a large number of postures and force combinations can be used to attain a stable grasp. Motor synergies provide a viable strategy to solve this problem of motor redundancy. In this study, we exploited the technical advantages of an innovative sensorized object to study unconstrained hand grasping within the theoretical framework of motor synergies. Participants were required to grasp, lift, and hold the sensorized object...
February 22, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28228262/targeting-dna-damage-response-in-prostate-cancer-by-inhibiting-androgen-receptor-cdc6-atr-chk1-signaling
#8
Styliani Karanika, Theodoros Karantanos, Likun Li, Jianxiang Wang, Sanghee Park, Guang Yang, Xuemei Zuo, Jian H Song, Sankar N Maity, Ganiraju C Manyam, Bradley Broom, Ana M Aparicio, Gary E Gallick, Patricia Troncoso, Paul G Corn, Nora Navone, Wei Zhang, Shuhua Li, Timothy C Thompson
Cell division cycle 6 (CDC6), an androgen receptor (AR) target gene, is implicated in regulating DNA replication and checkpoint mechanisms. CDC6 expression is increased during prostate cancer (PCa) progression and positively correlates with AR in PCa tissues. AR or CDC6 knockdown, together with AZD7762, a Chk1/2 inhibitor, results in decreased TopBP1-ATR-Chk1 signaling and markedly increased ataxia-telangiectasia-mutated (ATM) phosphorylation, a biomarker of DNA damage, and synergistically increases treatment efficacy...
February 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/28227946/analysis-of-effective-sit-to-stand-therapy-using-kinematic-synergies
#9
Bryan Lao, Tomoya Tamei, Kazushi Ikeda, Bryan Lao, Tomoya Tamei, Kazushi Ikeda, Tomoya Tamei, Bryan Lao, Kazushi Ikeda
Understanding effective sit-to-stand (STS) movement is essential for improving rehabilitation strategies and developing services for the rapidly increasing number of elderly people. This study aims at identifying effective STS therapy by analyzing the kinematic synergies of movements induced by therapists of different skill-levels. Three synergies were found to share the same temporal pattern in both joint angles and center-of-mass spaces across all therapists. Effective strategy used by a skilled therapist and strategy flaws of less-experienced therapists were revealed through comparison of spatial patterns...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227837/progressive-abduction-loading-therapy-targeting-flexion-synergy-to-regain-reaching-function-in-chronic-stroke-preliminary-results-from-an-rct
#10
Michael D Ellis, Carolina Carmona, Justin Drogos, Stuart Traxel, Julius P A Dewald, Michael D Ellis, Carolina Carmona, Justin Drogos, Stuart Traxel, Julius P A Dewald, Stuart Traxel, Michael D Ellis, Carolina Carmona, Julius P A Dewald, Justin Drogos
Reaching function is impaired following stroke due to abnormal coupling of shoulder abduction and elbow flexion. This phenomenon is commonly referred to as flexion synergy, loss of independent joint control, or impaired joint individuation. We have been successful in treating individuals with chronic stroke with moderate to severe motor impairments through the employment of targeted rehabilitation robotics and identified progressive abduction loading as a key element to the rehabilitation of reaching. Here we expand upon the investigation of progressive abduction loading therapy by testing two variants of the exercise in a larger sample and including a 3-month follow-up...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227662/towards-synergistic-control-of-hands-on-needle-insertion-with-automated-needle-steering-for-mri-guided-prostate-interventions
#11
Marek Wartenberg, Niravkumar Patel, Gang Li, Gregory S Fischer, Marek Wartenberg, Niravkumar Patel, Gang Li, Gregory S Fischer, Niravkumar Patel, Marek Wartenberg, Gregory S Fischer, Gang Li
A significant hurdle of accurate needle tip placement in percutaneous needle-based prostate interventions is unmodeled needle deflection and tissue deformation during insertion. This paper introduces a robotic platform for developing synergistic, cooperatively controlled needle insertion algorithms decoupled from closed-loop image-guided needle steering. Shared control of the surgical workspace through human-robot synergy creates a balance between the accuracy of robotic autonomy while still providing ultimate control of the procedure to the physician...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227194/exploring-neuro-muscular-synergies-of-reaching-movements-with-unified-independent-component-analysis
#12
Fiorenzo Artoni, Elvira Pirondini, Alessandro Panarese, Silvestre Micera, Fiorenzo Artoni, Elvira Pirondini, Alessandro Panarese, Silvestre Micera, Elvira Pirondini, Alessandro Panarese, Fiorenzo Artoni, Silvestro Micera
The coordinated recruitment of group of muscles through muscles synergies is known to simplify the control of movements. However, how and to what extent such control scheme is encoded at a cortical level is poorly understood. So far, electroencephalography (EEG) and electromyography (EMG) have been used, separately, to investigate the cortical regions of the human brain which may be involved in activating muscle synergies. Here we aim at extending these results by looking for a hierarchical relationship between cortical and muscular sources of activity (neuro-muscular synergies) with a unified analysis of independent components (IC) simultaneously extracted from both EEG and EMG signals...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226835/analysis-of-muscle-synergy-for-evaluation-of-task-specific-performance-in-stroke-patients
#13
Si Li, Cheng Zhuang, Xiao Zhang, Chuanxin M Niu, Qing Xie, Ning Lan, Si Li, Cheng Zhuang, Xiao Zhang, Chuanxin M Niu, Qing Xie, Ning Lan, Chuanxin M Niu, Xiao Zhang, Cheng Zhuang, Si Li, Ning Lan, Qing Xie
Muscle synergy represents a central neural module that organizes and activates a group of muscles when performing a certain task. However, whether muscle synergy is a good physiological indicator of motor ability in task performance for patients suffering stroke is not clear. The purpose of this study is to understand how information of task-specific muscle synergy in healthy subjects and patients post stroke can be used to evaluate their motor ability, and further to assist motor rehabilitation for stroke patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226831/muscle-synergy-analysis-in-transtibial-amputee-during-ramp-ascending-activity
#14
P Mehryar, M S Shourijeh, H F Maqbool, M Torabi, A A Dehghani-Sanij, P Mehryar, M S Shourijeh, H F Maqbool, M Torabi, A A Dehghani-Sanij, A A Dehghani-Sanij, M S Shourijeh, P Mehryar, M Torabi, H F Maqbool
In developed countries, the highest number of amputees are elderly with transtibial amputation. Walking on inclined surfaces is difficult for amputees due to loss of muscle volume and strength thereby transtibial amputees (TA) rely on the intact limb to maintain stability. The aim of this study was to use the concatenated non-negative matrix factorization (CNMF) technique to calculate muscle synergy components and compare the difference in muscle synergies and their associated activation profiles in the healthy and amputee groups during ramp ascending (RA) activity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226640/characterizing-muscular-activities-using-non-negative-matrix-factorization-from-emg-channels-for-driver-swings-in-golf
#15
Yasunori Ozaki, Ryosuke Aoki, Toshitaka Kimura, Youichi Takashima, Tomohiro Yamada, Yasunori Ozaki, Ryosuke Aoki, Toshitaka Kimura, Youichi Takashima, Tomohiro Yamada, Yasunori Ozaki, Youichi Takashima, Tomohiro Yamada, Toshitaka Kimura, Ryosuke Aoki
The goal of this study is to propose a data driven approach method to characterize muscular activities of complex actions in sports such as golf from a lot of EMG channels. Two problems occur in a many channel measurement. The first problem is that it takes a lot of time to check the many channel data because of combinatorial explosion. The second problem is that it is difficult to understand muscle activities related with complex actions. To solve these problems, we propose an analysis method of multi EMG channels using Non-negative Matrix Factorization and adopt the method to driver swings in golf...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226425/the-brain-can-mix-different-control-strategies-in-a-task-oriented-and-multi-referential-manner-a-simulation-study
#16
Pietro Morasso, Taishin Nomura, Yasuyuki Suzuki, Jacopo Zenzeri, Pietro Morasso, Taishin Nomura, Yasuyuki Suzuki, Jacopo Zenzeri, Jacopo Zenzeri, Taishin Nomura, Yasuyuki Suzuki, Pietro Morasso
In everyday life the brain must adapt to variable situations that may require a mixture of approaches including anticipatory synergy formation, through an internal body schema, and different control strategies. Unstable tasks are particularly challenging because deteriorate the predictive power of internal models and further enhance the instability potential of delayed sensory feedback. We explore this issue by means of three simulation studies: A) The hybrid control of a double inverted pendulum model, B) The bimanual stabilization of a saddle-like instability, C) Whole-body focal-postural dynamics...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224492/self-organizing-hidden-markov-model-map-sohmmm-biological-sequence-clustering-and-cluster-visualization
#17
Christos Ferles, William-Scott Beaufort, Vanessa Ferle
The present study devises mapping methodologies and projection techniques that visualize and demonstrate biological sequence data clustering results. The Sequence Data Density Display (SDDD) and Sequence Likelihood Projection (SLP) visualizations represent the input symbolical sequences in a lower-dimensional space in such a way that the clusters and relations of data elements are depicted graphically. Both operate in combination/synergy with the Self-Organizing Hidden Markov Model Map (SOHMMM). The resulting unified framework is in position to analyze automatically and directly raw sequence data...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28224049/the-role-of-topical-antiseptic-agents-within-antimicrobial-stewardship-strategies-for-prevention-and-treatment-of-surgical-site-and-chronic-open-wound-infection
#18
Christopher D Roberts, David J Leaper, Ojan Assadian
Scope and Significance: The topical use of antiseptics for wound care has a role in an antimicrobial stewardship strategy. However, the details of this role need clarification. Further clinical research into the use of topical antiseptics in wound care would lower the risk of furthering antibiotic resistance and contribute to more effective antibiotic use. As part of this research, experimental and surveillance data are needed on the resistance and tolerance patterns associated with topical antiseptic use in wound infections...
February 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28222405/thyroid-hormones-a-potential-ally-to-ldl-cholesterol-lowering-agents
#19
REVIEW
Leonidas N Duntas, Gabriela Brenta
L-thyroxine (LT4) treatment of hypothyroidism, particularly in patients with thyroid- stimulating hormone (TSH) >10mU/L, results in improved lipid profile, as LT4 stimulates low-density lipoprotein cholesterol (LDL-C) degradation and the conversion of cholesterol in bile acids by inducing LDL-receptor and 7 alpha hydroxylase expression, respectively. Statins decrease total cholesterol (TC) and LDL-C mainly by suppressing 3-hydroxy-3-methylglutaryl coenzyme A activity. Therefore, the addition of statins to LT4 treatment, following the reversal of hypothyroidism, acts synergistically and forms a powerful treatment modality in patients with this condition whose serum lipids have not achieved the target...
October 2016: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28220067/shared-and-task-specific-muscle-synergies-during-normal-walking-and-slipping
#20
Mohammad Moein Nazifi, Han Ul Yoon, Kurt Beschorner, Pilwon Hur
Falling accidents are costly due to their prevalence in the workplace. Slipping has been known to be the main cause of falling. Understanding the motor response used to regain balance after slipping is crucial to developing intervention strategies for effective recovery. Interestingly, studies on spinalized animals and studies on animals subjected to electrical microstimulation have provided major evidence that the Central Nervous System (CNS) uses motor primitives, such as muscle synergies, to control motor tasks...
2017: Frontiers in Human Neuroscience
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