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https://www.readbyqxmd.com/read/28922811/a-programme-to-create-short-course-chemotherapy-for-pulmonary-mycobacterium-avium-disease-based-on-pharmacokinetics-pharmacodynamics-and-mathematical-forecasting
#1
Devyani Deshpande, Shashikant Srivastava, Tawanda Gumbo
Objectives: Pulmonary Mycobacterium avium complex (MAC) prevalence is on the rise worldwide. The average therapy duration is 1.5 years, which is associated with poor cure rates. Our objective was to develop a programme to design a combination therapy regimen for pulmonary MAC to be administered for 6 months or less with efficacy in > 90% of patients. Methods: We performed a literature search for the following MeSH headings 'Mycobacterium avium' AND 'pharmacokinetics/pharmacodynamics' in PubMed up to 2016...
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28922338/does-the-%C3%AE-receptor-antagonist-esmolol-have-analgesic-effects-a-randomised-placebo-controlled-cross-over-study-on-healthy-volunteers-undergoing-the-cold-pressor-test
#2
Fredrik Ander, Anders Magnuson, Alex de Leon, Rebecca Ahlstrand
BACKGROUND: Esmolol may attenuate the sympathetic response to pain and reduce postoperative opioid consumption. It is not clear whether esmolol has an analgesic effect per se. OBJECTIVES: The aim of this study was to evaluate the analgesic effect of esmolol in the absence of anaesthetics and opioids. We tested the hypothesis that esmolol would reduce the maximum pain intensity perceived during the cold pressor test (CPT) by 2 points on a 0 to 10 numeric pain rating scale (NRS) compared to placebo...
September 15, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28921772/interplay-of-classic-exp-and-specific-vfm-quorum-sensing-systems-on-the-phenotypic-features-of-dickeya-solani-strains-exhibiting-different-virulence-levels
#3
Marta Potrykus, Nicole Hugouvieux-Cotte-Pattat, Ewa Lojkowska
Bacteria from the genus Dickeya cause severe symptoms on numerous economically important plants. D. solani is the Dickeya species most frequently found on infected potato plants in Europe. D. solani strains from different countries show high genetic homogeneity but significant differences in their virulence level. Dickeya species possess two quorum sensing (QS) mechanisms: the Exp system based on classic N-acyl-homoserine lactone (AHL) signals and a specific system depending on the production and perception of a molecule of unknown structure, Virulence Factor Modulating (VFM)...
September 18, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28921217/effect-of-lower-and-higher-alcohol-fuel-synergies-in-biofuel-blends-and-exhaust-treatment-system-on-emissions-from-ci-engine
#4
Thiyagarajan Subramanian, Edwin Geo Varuvel, Leenus Jesu Martin, Nagalingam Beddhannan
The present study deals with performance, emission and combustion studies in a single cylinder CI engine with lower and higher alcohol fuel synergies with biofuel blends and exhaust treatment system. Karanja oil methyl ester (KOME), widely available biofuel in India, and orange oil (ORG), a low carbon biofuel, were taken for this study, and equal volume blend was prepared for testing. Methanol (M) and n-pentanol (P) was taken as lower and higher alcohol and blended 20% by volume with KOME-ORG blend. Activated carbon-based exhaust treatment indigenous system was designed and tested with KOME-ORG + M20 and KOME-ORG + P20 blend...
September 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28921173/maximizing-safe-resections-the-roles-of-5-aminolevulinic-acid-and-intraoperative-mr-imaging-in-glioma-surgery-review-of-the-literature
#5
REVIEW
Eric Suero Molina, S Schipmann, W Stummer
Malignant glioma surgery involves the challenge of preserving the neurological status of patients harboring these lesions while pursuing a maximal tumor resection, which is correlated with overall and progression-free survival. Presently, several tools exist for assisting neurosurgeons in visualizing malignant tissue. Fluorescence-guided surgery (FGS) with 5-aminolevulinic acid (5-ALA) has increasingly been used during the last decade for identifying malignant glioma. Intraoperative magnetic resonance imaging (iMRI), first introduced in the mid-1990s, is being evaluated as a further tool to maximize the extent of resection...
September 18, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28921172/-european-network-of-official-medicines-control-laboratories-international-omcl-working-group-combating-counterfeit-and-other-illegal-medicines
#6
REVIEW
Richard Wanko, Uwe Unkelbach
Official medicines control laboratories (OMCLs) have for a long time been involved in testing activities related to suspected counterfeit or other illegal medicines in a number of European countries in support of national enforcement authorities. With the secretarial support of the European Directorate for the Quality of Medicines & HealthCare (EDQM), from 2005 onwards, the General European OMCL Network (GEON) has gradually introduced for its members tailored tools, joint test programmes and information/discussion platforms in the field of falsified medicines testing...
September 18, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28918429/synergy-of-dendritic-cell-vaccines-and-avasimibe-in-treatment-of-head-and-neck-cancer-in-mice
#7
Xin Chen, Qibin Song, Leiming Xia, Ximing Xu
BACKGROUND The main purpose of this study was to explore the antitumor effect and mechanisms of ACAT1 inhibitor combined with CSCs-DC vaccine. MATERIAL AND METHODS We isolated HNSCC CSCs and gained CSCs antigens, then used CSCs antigens to load dendritic cells (DC) and generated a CSCs-DC vaccine. We treated mice after surgical excision of established SCC7 tumors with CSCs-DC vaccine and/or ACAT1 inhibitor, and recorded local tumor relapse and host survival. T cells and B cells were harvested from mice treated with CSCs-DC vaccine and/or ACAT1 inhibitor...
September 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28917836/erythromycin-encapsulation-in-nanoemulsion-based-delivery-systems-for-treatment-of-helicobacter-pylori-infection-protection-and-synergy
#8
Le Tuyet Chau Tran, Claire Gueutin, Ghislaine Frebourg, Christophe Burucoa, Vincent Faivre
Poorly water-soluble and unstable compounds are difficult to develop as drug products using conventional formulation techniques. The aim of the present study was to develop and evaluate a nanoformulation prepared by a hot high-pressure homogenization method, which was a scalable and solvent-free process. We successfully prepared stable nanodispersions to protect a labile antibiotic, erythromycin. The mean diameter of the dispersed droplets was approximately 150 nm, and size distribution was unimodal. Dispersion was physically stable at room temperature for over six months...
September 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28917740/switchable-zipper-like-thermoresponsive-molecularly-imprinted-polymers-for-selective-recognition-and-extraction-of-estradiol
#9
Huihuang Xiong, Xiaqing Wu, Wenhui Lu, Junqing Fu, Hailong Peng, Jinhua Li, Xiaoyan Wang, Hua Xiong, Lingxin Chen
Zipper-like thermoresponsive molecularly imprinted polymers (MIPs) were prepared based on interpolymer complexation via the synergy of dual functional monomers of acrylamide (AAm) and 2-acrylamide-2-methyl propanesulfonic acid (AMPS) for selective recognition and extraction of estradiol (E2) by temperature regulation. The resulting E2-MIPs attained controlled adsorption and release of E2 in response to temperature change, with higher adsorption capacity (8.78mg/g) and stronger selectivity (imprinting factor was 3...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917581/an-engineering-insight-into-the-relationship-of-selective-cytoskeletal-impairment-and-biomechanics-of-hela-cells
#10
Daniele Borin, Luca Puzzi, Valentina Martinelli, Matteo Cibinel, Romano Lapasin, Orfeo Sbaizero
It is widely accepted that the pathological state of cells is characterized by a modification of mechanical properties, affecting cellular shape and viscoelasticity as well as adhesion behaviour and motility. Thus, assessing these parameters could represent an interesting tool to monitor disease development and progression, but also the effects of drug treatments. Since biomechanical properties of cells are strongly related to cytoskeletal architecture, in this work we extensively studied the effects of selective impairments of actin microfilaments and microtubules on HeLa cells through force-deformation curves and stress relaxation tests with atomic force microscopy...
September 8, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28917156/tgf%C3%AE-1-synergizes-with-flt3-ligand-to-induce-chemoresistant-quiescence-in-acute-lymphoblastic-leukemia-with-mll-gene-rearrangements
#11
M Tamai, Y Furuichi, S Kasai, N Ando, D Harama, K Goi, T Inukai, K Kagami, M Abe, H Ichikawa, K Sugita
Fms-like tyrosine kinase 3 (FLT3) is highly expressed in mixed-lineage leukemia (MLL) gene-rearranged acute lymphoblastic leukemia (MLL+ALL) with a dismal prognosis. We previously reported that FLT3 ligand (FL) stimulation induced cell cycle arrest in MLL+ALL cells leading to resistance against anti-leukemic agents. Given that FL stimulation enhanced transforming growth factor (TGF)β1 mRNA levels in MLL+ALL cells, we extensively examined the effect of TGFβ1 on the cell cycle progression and chemosensitivity in MLL+ALL cells, and found that TGFβ1 stimulation induced MLL+ALL cells into cell cycle arrest resistant to arabinosyl cytosine; its effect was markedly enhanced in synergy with FL...
September 13, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28915097/synergies-and-motor-equivalence-in-voluntary-sway-tasks-the-effects-of-visual-and-mechanical-constraints
#12
Mariusz P Furmanek, Stanisław Solnik, Daniele Piscitelli, Omid Rasouli, Ali Falaki, Mark L Latash
The authors used two analyses developed within the framework of the uncontrolled manifold hypothesis to quantify multimuscle synergies during voluntary body sway: analysis of intertrial variance and analysis of motor equivalence with respect to the center of pressure (COP) trajectory. Participants performed voluntary sway tasks in the anteroposterior direction at 0.33 and 0.66 Hz. Muscle groups were identified in the space of muscle activations and used as elemental variables in the synergy analyses. Changing mechanical and vision feedback-based constraints led to significant changes in indices of sway performance such as COP deviations in the uninstructed, mediolateral direction and indices of spontaneous postural sway...
September 15, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28914554/when-cooperation-goes-wrong-brain-and-behavioral-correlates-of-ineffective-joint-strategies-in-dyads
#13
Michela Balconi, Laura Gatti, Maria Elide Vanutelli
Human life is connoted by sophisticated interactions that involve not only single individuals, but larger social groups composed by members interacting each other. Cooperation secures a benefit to all the people engaged as well as important behaviors like helping, sharing, and acting prosocially. But what happens when the joint actions are not effective? In the present study we asked 24 participants paired in 12 dyads to cooperate during an attentional task in a way to synchronize their responses and obtain better outcomes...
September 15, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28913883/interactions-between-erythromycin-flunixin-meglumine-levamisole-and-plant-secondary-metabolites-towards-bovine-gastrointestinal-motility-in-vitro-study
#14
M Mendel, M Chłopecka, N Dziekan, W Karlik
Continued ingestion of plant secondary metabolites by ruminants can provoke pharmacological interactions with pharmaceutical agents used in animals. As some drugs and phytocompounds affect smooth muscle activity, the aim of this study was to verify the possible interaction between selected pharmaceutical agents and plant secondary metabolites towards bovine gastrointestinal motility. The interactions between phytocompounds-apigenin, quercetin, hederagenin, medicagenic acid-and medicines-erythromycin, flunixin meglumine and levamisole-were evaluated on bovine isolated abomasal and duodenal specimens obtained from routinely slaughtered cows...
September 14, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28913561/conformational-rearrangement-of-1-2-d-gg-intrastrand-cis-diammineplatinum-crosslinked-dna-is-driven-by-counter-ion-penetration-within-the-minor-groove-of-the-modified-site
#15
Tsvetan G Gantchev, Peicho St Petkov, Darel J Hunting
The major structural aberrations of DNA induced by a cis-diammineplatinum (II) 1,2-d(GG) intrastrand cross-link (CPT) have been known for decades. To gain deeper insights into the structural dynamics of the sequence-dependent DNA distortions adjacent to the CPT adduct, we employed molecular modeling and molecular dynamics (MD) simulations. The structural dynamics of native (N-DNA) and cisPt 1,2-d(GG) crosslinked (CPT-DNA) in the form of symmetric 36 nt d(G2T15G*G*T15G2)●C2A15CCA15C2) oligonucleotide duplexes is compared...
September 14, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28912707/methodological-choices-in-muscle-synergy-analysis-impact-differentiation-of-physiological-characteristics-following-stroke
#16
Caitlin L Banks, Mihir M Pai, Theresa E McGuirk, Benjamin J Fregly, Carolynn Patten
Muscle synergy analysis (MSA) is a mathematical technique that reduces the dimensionality of electromyographic (EMG) data. Used increasingly in biomechanics research, MSA requires methodological choices at each stage of the analysis. Differences in methodological steps affect the overall outcome, making it difficult to compare results across studies. We applied MSA to EMG data collected from individuals post-stroke identified as either responders (RES) or non-responders (nRES) on the basis of a critical post-treatment increase in walking speed...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28912700/action-direction-of-muscle-synergies-in-voluntary-multi-directional-postural-control
#17
Akari Kubo, Shota Hagio, Benio Kibushi, Toshio Moritani, Motoki Kouzaki
A muscle synergy is a coordinative structure of muscles that has been proposed as a strategy to reduce the number of variables that the central nervous system (CNS) has to address in motor tasks. In this article, the mechanical contribution of muscle synergies and coordinative structures of muscles in voluntary multi-directional postural control were investigated. The task for healthy, young subjects was to shift and align their center of pressure (COP) to targets dispersed in 12 different directions in the horizontal plane by leaning their bodies for 10 s...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28912090/immuno-oncology-and-its-opportunities-for-interventional-radiologists-immune-checkpoint-inhibition-and-potential-synergies-with-interventional-oncology%C3%A2-procedures
#18
REVIEW
Ryan M Hickey, Laura M Kulik, Halla Nimeiri, Aparna Kalyan, Sheetal Kircher, Kush Desai, Ahsun Riaz, Robert J Lewandowski, Riad Salem
Immunotherapy, specifically the use of immune checkpoint inhibitors, offers a new approach to fighting cancer. Although the results of treatment with immune checkpoint inhibition alone have been remarkable for certain cancers, these results are not universal. Preclinical and early clinical studies indicate the potential for synergistic effects when immune checkpoint inhibition is combined with immunogenic local therapies such as ablation and embolization. This review offers an overview of immunology as it relates to immune checkpoint inhibition and the possibilities for synergy when combined with interventional radiology treatments...
September 12, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28911622/sedative-and-hypnotic-effects-of-supercritical-carbon-dioxide-fluid-extraction-from-schisandra-chinensis-in-mice
#19
Hongyan Zhu, Lina Zhang, Guoli Wang, Zhongmei He, Yan Zhao, Yonghua Xu, Yugang Gao, Lianxue Zhang
Schisandra chinensis is a traditional Chinese medicine that has been used for treating insomnia and neurasthenia for centuries. Lignans, which are considered to be the bioactive components, are apt to be extracted by supercritical carbon dioxide. This study was conducted to investigate the sedative and hypnotic activities of the supercritical carbon dioxide fluid extraction of S. chinensis (SFES) in mice and the possible mechanisms. SFES exhibited an obvious sedative effect on shortening the locomotor activity in mice in a dose-dependent (10-200 mg/kg) manner...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911115/the-ires5-utr-of-the-dicistrovirus-cricket-paralysis-virus-is-a-type-iii-ires-containing-an-essential-pseudoknot-structure
#20
Lauriane Gross, Quentin Vicens, Evelyne Einhorn, Audrey Noireterre, Laure Schaeffer, Lauriane Kuhn, Jean-Luc Imler, Gilbert Eriani, Carine Meignin, Franck Martin
Cricket paralysis virus (CrPV) is a dicistrovirus. Its positive-sense single-stranded RNA genome contains two internal ribosomal entry sites (IRESs). The 5' untranslated region (5'UTR) IRES5'UTR mediates translation of non-structural proteins encoded by ORF1 whereas the well-known intergenic region (IGR) IRESIGR is required for translation of structural proteins from open reading frame 2 in the late phase of infection. Concerted action of both IRES is essential for host translation shut-off and viral translation...
September 6, 2017: Nucleic Acids Research
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