Jinhong Zhou, Moath Refat, Yucheng Guo, Jiaxin Zhang, Min Jiao, Wenbo He, Xiaoyu He, Mai A Rabie, Zhenlin Ouyang, Fang Zheng
Staphylococcus aureus is a major cause of hospital-associated infections worldwide. The organism's ability to form biofilms has led to resistance against current treatment options such as beta-lactams, glycopeptides, and daptomycin. The ArlRS two-component system is a crucial regulatory system necessary for S. aureus autolysis, biofilm formation, capsule synthesis, and virulence. This study aims to investigate the role of the arlR deletion mutant in the detection and activation of S. aureus. We created an arlR deleted mutant and complementary strains and characterized their impact on the strains using partial growth measurement...
March 26, 2024: Applied Biochemistry and Biotechnology