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https://www.readbyqxmd.com/read/28823093/candida-albicans-staphylococcus-aureus-dual-species-biofilm-as-a-target-for-the-combination-of-essential-oils-and-fluconazole-or-mupirocin
#1
Aleksandra Budzyńska, Sylwia Różalska, Beata Sadowska, Barbara Różalska
The effectiveness of essential oils (EOs), fluconazole (FLU) and mupirocin (MUP) used alone or in combination against mono-species and mixed Candida albicans/Staphylococcus aureus biofilms was examined. An experimentally established dual-species biofilm model, verified by fluorescence microscopy and viable cell counting, was used. Selected commercial EOs were tested: geranium, citronella and clove oils, which have been chemically characterized and found to differ in the content of the main components (qualitative and quantitative)...
August 19, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28823033/the-combination-of-mitomycin-induced-blood-cells-with-a-temporary-treatment-of-ciclosporin-a-prolongs-allograft-survival-in-vascularized-composite-allotransplantation
#2
Christian Andreas Radu, Sebastian Fischer, Yannick Diehm, Otto Hetzel, Florian Neubrech, Laura Dittmar, Christian Kleist, Martha Maria Gebhard, Peter Terness, Ulrich Kneser, Jurij Kiefer
BACKGROUND: Vascularized composite allotransplantation (VCA) is a rapidly expanding field of transplantation and provides a potential treatment for complex tissue defects. Peripheral blood mononuclear cells (PBMCs) shortly incubated with the antibiotic and chemotherapeutic agent mitomycin C (MMC) can suppress allogeneic T cell response and control allograft rejection in various organ transplantation models. MMC-incubated PBMCs (MICs) are currently being tested in a phase I clinical trial in kidney transplant patients...
August 19, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28822976/persistence-after-treatment-of-pharyngeal-gonococcal-infections-in-patients-of-the-sti-clinic-amsterdam-the-netherlands-2012-2015-a-retrospective-cohort-study
#3
I Putu Yuda Hananta, Henry John Christiaan De Vries, Alje P van Dam, Martijn Sebastiaan van Rooijen, Hardyanto Soebono, Maarten Franciscus Schim van der Loeff
INTRODUCTION: Infection of Neisseria gonorrhoeae in the pharynx (pharyngeal Ng) is associated with gonococcal transmission and development of antimicrobial resistance. We assessed proportion of and determinants for persistence after treatment of pharyngeal Ng. METHODS: At the STI clinic of Amsterdam, the Netherlands, females-at-risk and men who have sex with men are routinely screened for pharyngeal Ng using an RNA-based nucleic acid amplification test (NAAT; Aptima Combo 2)...
August 19, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28820752/antibiotic-combination-therapy-for-patients-with-gram-negative-septic-shock
#4
Andre C Kalil
No abstract text is available yet for this article.
August 17, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28820705/the-impact-of-introducing-malaria-rapid-diagnostic-tests-on-fever-case-management-a-synthesis-of-ten-studies-from-the-act-consortium
#5
Katia J Bruxvoort, Baptiste Leurent, Clare I R Chandler, Evelyn K Ansah, Frank Baiden, Anders Björkman, Helen E D Burchett, Sîan E Clarke, Bonnie Cundill, Debora D DiLiberto, Kristina Elfving, Catherine Goodman, Kristian S Hansen, S Patrick Kachur, Sham Lal, David G Lalloo, Toby Leslie, Pascal Magnussen, Lindsay Mangham-Jefferies, Andreas Mårtensson, Ismail Mayan, Anthony K Mbonye, Mwinyi I Msellem, Obinna E Onwujekwe, Seth Owusu-Agyei, Mark W Rowland, Delér Shakely, Sarah G Staedke, Lasse S Vestergaard, Jayne Webster, Christopher J M Whitty, Virginia L Wiseman, Shunmay Yeung, David Schellenberg, Heidi Hopkins
Since 2010, the World Health Organization has been recommending that all suspected cases of malaria be confirmed with parasite-based diagnosis before treatment. These guidelines represent a paradigm shift away from presumptive antimalarial treatment of fever. Malaria rapid diagnostic tests (mRDTs) are central to implementing this policy, intended to target artemisinin-based combination therapies (ACT) to patients with confirmed malaria and to improve management of patients with nonmalarial fevers. The ACT Consortium conducted ten linked studies, eight in sub-Saharan Africa and two in Afghanistan, to evaluate the impact of mRDT introduction on case management across settings that vary in malaria endemicity and healthcare provider type...
August 7, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28820693/clinical-features-of-intermittent-migratory-swelling-caused-by-gnathostomiasis-with-complete-follow-up
#6
Chollasap Sharma, Watcharapong Piyaphanee, Dorn Watthanakulpanich
A 15-year-old Thai girl was referred to the Hospital for Tropical Diseases of Mahidol University with a 3-week history of an intermittent migratory mass on the forehead. She was diagnosed with cutaneous gnathostomiasis. The patient was treated with albendazoleat 400 mg orally twice a day for 3 weeks, with good compliance. She revisited the hospital after 3 months and was seen to have been unresponsive to the initial treatment. There was intermittent swelling in her right upper eyelid along with mild redness around her right upper and lower eyelids...
August 7, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28818332/antimicrobial-activity-and-acetylcholinesterase-inhibition-by-extracts-from-chromatin-modulated-fungi
#7
Matheus Thomaz Nogueira Silva Lima, Larissa Batista Dos Santos, Rafael Wesley Bastos, Jacques Robert Nicoli, Jacqueline Aparecida Takahashi
Major health challenges as the increasing number of cases of infections by antibiotic multiresistant microorganisms and cases of Alzheimer's disease have led to searching new control drugs. The present study aims to verify a new way of obtaining bioactive extracts from filamentous fungi with potential antimicrobial and acetylcholinesterase inhibitory activities, using epigenetic modulation to promote the expression of genes commonly silenced. For such finality, five filamentous fungal species (Talaromyces funiculosus, Talaromyces islandicus, Talaromyces minioluteus, Talaromyces pinophilus, Penicillium janthinellum) were grown or not with DNA methyltransferases inhibitors (procainamide or hydralazine) and/or a histone deacetylase inhibitor (suberohydroxamic acid)...
August 1, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28817561/comparing-efficacies-of-moxifloxacin-levofloxacin-and-gatifloxacin-in-tuberculosis-granulomas-using-a-multi-scale-systems-pharmacology-approach
#8
Elsje Pienaar, Jansy Sarathy, Brendan Prideaux, Jillian Dietzold, Véronique Dartois, Denise E Kirschner, Jennifer J Linderman
Granulomas are complex lung lesions that are the hallmark of tuberculosis (TB). Understanding antibiotic dynamics within lung granulomas will be vital to improving and shortening the long course of TB treatment. Three fluoroquinolones (FQs) are commonly prescribed as part of multi-drug resistant TB therapy: moxifloxacin (MXF), levofloxacin (LVX) or gatifloxacin (GFX). To date, insufficient data are available to support selection of one FQ over another, or to show that these drugs are clinically equivalent. To predict the efficacy of MXF, LVX and GFX at a single granuloma level, we integrate computational modeling with experimental datasets into a single mechanistic framework, GranSim...
August 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28816443/characterization-of-ciprofloxacin-permeation-pathways-across-the-porin-ompc-using-metadynamics-and-a-string-method
#9
Jigneshkumar Dahyabhai Prajapati, Carlos José Fernández Solano, Mathias Winterhalter, Ulrich Kleinekathöfer
The rapid spreading of antimicrobial resistance in Gram-negative bacteria has become a major threat for humans as well as animals. As one of the main factors involved, the permeability of the outer membrane has attracted quite some attention recently. However, the knowledge regarding the translocation mechanisms for most available antibiotics is so far rather limited. Here, a theoretical study concerning the diffusion route of ciprofloxacin across the outer membrane porin OmpC from E. coli is presented. To this end, we establish a protocol to characterize meaningful permeation pathways by combining metadynamics with the zero-temperature string method...
August 17, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28816432/an-integrated-microsystem-for-real-time-detection-and-threshold-activated-treatment-of-bacterial-biofilms
#10
Sowmya Subramanian, Ekaterina I Tolstaya, Thomas Winkler, William E Bentley, Reza Ghodssi
Bacterial biofilms are the primary cause of infections in medical implants and catheters. Delayed detection of biofilm infections contributes to the widespread use of high doses of antibiotics, leading to the emergence of antibiotic-resistant bacterial strains. Accordingly, there is an urgent need for systems that can rapidly detect and treat biofilm infections in situ. As a step towards this goal, in this work we have developed for the first time a threshold-activated feedback-based impedance sensor-treatment system for combined real-time detection and treatment of biofilms...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28816060/the-broad-spectrum-antimicrobial-potential-of-mn-co-4-s2cnme-ch2co2h-a-water-soluble-co-releasing-molecule-corm-401-intracellular-accumulation-transcriptomic-and-statistical-analyses-and-membrane-polarization
#11
Lauren Katie Wareham, Samantha McLean, Ronald Begg, Namrata Rana, Salar Ali, John J Kendall, Guido Sanguinetti, Brian E Mann, Robert K Poole
AIMS: Carbon monoxide (CO)-releasing molecules (CORMs) are candidates for animal and antimicrobial therapeutics. We aimed to probe the antimicrobial potential of a novel manganese CORM. RESULTS: [Mn(CO)4S2CNMe(CH2CO2H)], CORM-401, inhibits growth of Escherichia coli and several antibiotic-resistant clinical pathogens. CORM-401 releases CO that binds oxidases in vivo but is an ineffective respiratory inhibitor. Extensive CORM accumulation (assayed as intracellular manganese) accompanies antimicrobial activity...
August 17, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28814888/frequency-of-colistin-and-fosfomycin-resistance-in-carbapenem-resistant-enterobacteriaceae-from-a-tertiary-care-hospital-in-karachi
#12
Salima Qamar, Najma Shaheen, Sadia Shakoor, Joveria Farooqi, Kauser Jabeen, Rumina Hasan
INTRODUCTION: Management of infections with carbapenem-resistant Enterobacteriaceae (CRE) is challenging. In recent times, agents such as colistin and fosfomycin have been used in combination with other antibiotics to treat such infections. In this study, we aim to seek frequency of colistin and fosfomycin resistance in CRE from Pakistan. METHODS: This study was conducted at clinical laboratories, Aga Khan University Hospital. In total, 251 CRE were included in the study...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28814309/performance-biochemical-and-haematological-responses-and-relative-organ-weights-of-laying-hens-fed-diets-supplemented-with-prebiotic-probiotic-and-synbiotic
#13
Shirley Gee Hoon Tang, Chin Chin Sieo, Kalavathy Ramasamy, Wan Zuhainis Saad, Hee Kum Wong, Yin Wan Ho
BACKGROUND: The increasing trend of ban on the use of antibiotic growth promoters (AGPs) across the globe in the poultry industry has led to a growing need for alternatives to AGPs. Prebiotic, probiotic and their combination as a synbiotic have been considered as potential alternatives. This study aimed to investigate the effects of a prebiotic (isomaltooligosaccharide, IMO), a probiotic (PrimaLac®), and their combination (synbiotic) on hen performance, biochemical and haematological responses, and relative organ weights from 20 to 52 weeks of age...
August 17, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28814255/current-evidence-on-the-evaluation-and-management-of-fever-without-a-source-in-infants-aged-0-90-days-a-review
#14
Joyee G Vachani, Kenya McNeal-Trice, Sowdhamini S Wallace
BACKGROUND: Despite development of risk stratification tools decades ago, the best strategy for evaluation and management of young infants with fever without a clear source remains uncertain. OBJECTIVE: To describe the variability in current practice and review recently published evidence in three key areas: inflammatory markers as a tool for risk stratification, impact of viral testing, and optimal observation time on antibiotics. METHODS: Articles were identified using PubMed, Scopus, and Cochrane databases and via experts...
August 16, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28813557/facial-erosive-pustular-dermatosis-after-cosmetic-resurfacing
#15
Julie E Mervak, Stephanie D Gan, Emily H Smith, Frank Wang
Importance: Erosive pustular dermatosis (EPD) is a rare condition that typically affects actinically damaged skin of the scalp. Characterized by sterile pustules, erosions, and crusts, EPD is difficult to treat and heals slowly. The exact cause of EPD is unknown, although trauma is an inciting factor. Objective: To describe 3 women who presented with prolonged facial erosions after cosmetic resurfacing procedures, specifically fully ablative carbon dioxide laser or medium-depth chemical peel...
August 16, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28812417/lacrimal-gland-abscesses-case-series-and-literature-review
#16
Brian Savoie, Rand Rodgers, Matthew Gorski
Acute dacryoadenitis with abscess formation has been rarely described. We describe four cases that resolved with incision and drainage. This includes a retrospective case series of four patients with radiologically confirmed lacrimal gland abscesses and a review of the reported cases in the literature. Computed tomography showed characteristic rim enhancing collections with central attenuation in all four cases. All patients presented with ptosis, upper eyelid erythema, and severe pain similar to scleritis...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28811162/engineering-peptidoglycan-degradation-related-genes-of-bacillus-subtilis-for-better-fermentation-processes
#17
Liang Zhao, Jianwen Ye, Jing Fu, Guo-Qiang Chen
In this study, Bacillus subtilis 168 Δupp was engineered to change the bacterial shapes. Namely, some peptidoglycan hydrolase related genes were inactivated individually or in different combinations, including sigD, lytE, lytF, lytC, lytD and lytG. Inactivations of these genes resulted in various intensities of blockages on cell division, leading to elongation of bacterial cells. The resulted fiber phenotypes showed different lengths ranging from tens of microns to several millimeters. Mutants with multiple gene inactivations such as ΔsigDΔlytEΔlytD showed more easily precipitated phenomenon, obviously increased growth rate, more sensitive to antibiotics and improved α-amylase production compared with that of B...
June 23, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28810368/public-health-messages-about-antibiotic-treatment-for-respiratory-tract-infection-may-increase-perceived-symptom-severity-reporting
#18
Claire Lawrence, Eamonn Ferguson
Public health campaigns to reduce expectations for antibiotic treatment for respiratory tract infections have shown little or no effect on antibiotic prescribing and consumption. We examined whether such messages can increase respiratory tract infection symptom reporting. Participants ( N = 318) received one of four campaign messages, a combination of all four messages, or no message. Respiratory tract infection symptoms increased for those who received information that emphasized the ineffectiveness of antibiotic treatment for respiratory tract infections...
December 1, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/28810137/time-gated-luminescence-imaging-of-singlet-oxygen-photoinduced-by-fluoroquinolones-and-functionalized-graphenes-in-daphnia-magna
#19
Tianlie Luo, Jingwen Chen, Bo Song, Hua Ma, Zhiqiang Fu, Willie J G M Peijnenburg
Singlet oxygen ((1)O2) can be photogenerated by photoactive xenobiotics and is capable of causing adverse effects due to its electrophilicity and its high reactivity with biological molecules. Detection of the production and distribution of (1)O2 in living organisms is therefore of great importance. In this study, a luminescent probe ATTA-Eu(3+) combined with time-gated luminescence imaging was adopted to detect the distribution and temporal variation of (1)O2 photoinduced by fluoroquinolone antibiotics and carboxylated/aminated graphenes in Daphnia magna...
July 29, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28809441/design-and-fabrication-of-temperature-sensitive-nanogels-with-controlled-drug-release-properties-for-enhanced-photothermal-sterilization
#20
Luoyuan Li, Limin Fu, Jing Zhou, Xicheng Ai, Jianping Zhang
Excessive free radicals can cause normal protein metamorphic, and further damage healthy cells, while the damaged cells are more prone to infection with pathogenic bacteria. For better removing excessive free radicals and deleterious bacteria from human body, it is urgently needed to develop synergistic antioxidant and antibacterial agents. Herein, we designed novel temperature-sensitive, curcumin (Cur)-loaded nanogels to scavenge reactive oxygen species and kill pathogenic bacteria. Photothermal sterilization, different from traditional antibiotics, is a promising and effective treatment for inactivation of pathogenic bacteria...
August 15, 2017: Chemistry: a European Journal
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