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https://www.readbyqxmd.com/read/29470546/computer-simulations-reveal-changes-in-the-conformational-space-of-the-transcriptional-regulator-mosr-upon-the-formation-of-a-disulphide-bond-and-in-the-collective-motions-that-regulate-its-dna-binding-affinity
#1
Amanda Souza Câmara, Eduardo Horjales
M. tuberculosis oxidation sense Regulator (MosR) is a transcriptional regulator from Mycobacterium tuberculosis. It senses the environment oxidation and regulates the expression of a secreted oxidoreductase, thus defending the bacilli against oxidative stress from the phagosome. While most of the members of the Multiple antibiotics resistance Regulator (MarR) family are ligand-responsive, MosR may dissociate from its DNA site upon formation of an intrachain disulphide bond. However, the structure of MosR in its oxidized state is not known, and it is not clear how the formation of this disulphide bond would lead to the conformational changes required for dissociation of the DNA...
2018: PloS One
https://www.readbyqxmd.com/read/29470491/emergence-of-klebsiella-pneumoniae-subspecies-pneumoniae-as-a-cause-of-septicaemia-in-pigs-in-england
#2
Cornelia A Bidewell, Susanna M Williamson, Jon Rogers, Yue Tang, Richard J Ellis, Liljana Petrovska, Manal AbuOun
Between 2011 and 2014 outbreaks of septicaemia due to Klebsiella pneumoniae subspecies pneumoniae (Kpp) were diagnosed on thirteen English pig farms. The most consistent features were rapid deaths of pigs from ten-days-old to weaning, seasonal occurrence (May to September), affected farms being outdoor breeding herds and the location of all but one of the outbreaks in the East Anglia region in Eastern England. Molecular characterisation of the outbreak Kpp isolates showed that by multilocus sequencing all were sequence type 25 (ST25) of K2 capsular type with a combination of a 4...
2018: PloS One
https://www.readbyqxmd.com/read/29470489/integration-of-machine-learning-and-meta-analysis-identifies-the-transcriptomic-bio-signature-of-mastitis-disease-in-cattle
#3
Somayeh Sharifi, Abbas Pakdel, Mansour Ebrahimi, James M Reecy, Samaneh Fazeli Farsani, Esmaeil Ebrahimie
Gram-negative bacteria such as Escherichia coli (E. coli) are assumed to be among the main agents that cause severe mastitis disease with clinical signs in dairy cattle. Rapid detection of this disease is so important in order to prevent transmission to other cows and helps to reduce inappropriate use of antibiotics. With the rapid progress in high-throughput technologies, and accumulation of various kinds of '-omics' data in public repositories, there is an opportunity to retrieve, integrate, and reanalyze these resources to improve the diagnosis and treatment of different diseases and to provide mechanistic insights into host resistance in an efficient way...
2018: PloS One
https://www.readbyqxmd.com/read/29469347/-mri-findings-of-cerebral-schistosomiasis-in-acute-stage%C3%AF-establishment-of-experimental-model-of-acute-cerebral-schistosomiasis-with-rabbits
#4
Ge Yu-Xi, Zhang Lian-He, Yan Gen, Zhang Jian-Feng, Pan Yong-Ming, Xuan Ying-Hua
OBJECTIVE: To establish an experimental model of acute cerebral schistosomiasis japonica and explore the MRI manifestations of acute cerebral schistosomiasis. METHODS: Rabbits were divided into 3 groups with 10 rabbits in each group. The rabbits in the experimental group were directly injected with suspension fluid of Schistosoma japonicum eggs (0.9 mg, 1 ml) by the cranial drilling method, those in the negative control group were given saline (1 ml) by the same method above-mentioned, and those in the blank control group were not given any treatment...
June 26, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29467474/an-in-vitro-proof-of-principle-study-of-sonobactericide
#5
Kirby R Lattwein, Himanshu Shekhar, Willem J B van Wamel, Tammy Gonzalez, Andrew B Herr, Christy K Holland, Klazina Kooiman
Infective endocarditis (IE) is associated with high morbidity and mortality rates. The predominant bacteria causing IE is Staphylococcus aureus (S. aureus), which can bind to existing thrombi on heart valves and generate vegetations (biofilms). In this in vitro flow study, we evaluated sonobactericide as a novel strategy to treat IE, using ultrasound and an ultrasound contrast agent with or without other therapeutics. We developed a model of IE biofilm using human whole-blood clots infected with patient-derived S...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29466956/outcome-and-prognostic-factors-of-patients-with-right-sided-infective-endocarditis-requiring-intensive-care-unit-admission
#6
Hugues Georges, Olivier Leroy, Norair Airapetian, Nicolas Lamblin, Elie Zogheib, Patrick Devos, Sebastien Preau
BACKGROUND: Right-sided infective endocarditis (RSIE) is an uncommon diagnosis accounting for less than 10% of cases of infective endocarditis. Optimal management for severely ill patients with RSIE remains challenging because few studies reported on management and outcome. The goal of our study was to determine outcome and associated prognostic factors in a population of ICU patients with a diagnosis of definite, active and severe RSIE. METHODS: We performed a retrospective study in 10 French ICUs between January 2002 and December 2012...
February 21, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29465747/antibiotics-for-treating-gonorrhoea-in-pregnancy
#7
REVIEW
Gabriella Comunián-Carrasco, Guiomar E Peña-Martí, Arturo J Martí-Carvajal
BACKGROUND: Gonorrhoea is a sexually transmitted infection that is caused by Neisseria gonorrhoeae, and is a major public health challenge today. N gonorrhoeae can be transmitted from the mother's genital tract to the newborn during birth, and can cause gonococcal ophthalmia neonatorum as well as systemic neonatal infections. It can also cause endometritis and pelvic sepsis in the mother. This review updates and replaces an earlier Cochrane Review on antibiotics for treating this infectious condition...
February 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29465589/high-dose-tigecycline-for-the-treatment-of-nosocomial-carbapenem-resistant-klebsiella-pneumoniae-bloodstream-infections-a-retrospective-cohort-study
#8
Ting-Ting Geng, Xin Xu, Man Huang
Carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infection (BSI) has become increasingly frequent threat recently, especially in the intensive care unit (ICU). High-dose tigecycline (TGC) regimen is proposed due to the limitation of treatment options. We investigated the efficacy and safety of high-dose TGC combination regimens for treating CRKP BSI. Furthermore, the risk factors for mortality were also determined.This was a single center retrospective cohort study conducted from 2014 to 2016. A total of 40 patients with nosocomial CRKP BSI admitted to the ICU were included; they were classified into two groups according to the treatment regimens with high-dose TGC (HD group) or not (non-HD group)...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29464798/bioactive-compounds-from-the-african-medicinal-plant-cleistochlamys-kirkii-as-resistance-modifiers-in-bacteria
#9
Annamária Kincses, Borisz Varga, Ákos Csonka, Shirley Sancha, Silva Mulhovo, Ana Margarida Madureira, Maria-José U Ferreira, Gabriella Spengler
Cleistochlamys kirkii (Benth) Oliv. (Annonaceae) is a medicinal plant traditionally used in Mozambique to treat infectious diseases. The aim of this study was to find resistance modifiers in C. kirkii for Gram-positive and Gram-negative model bacterial strains. One of the most important resistance mechanisms in bacteria is the efflux pump-related multidrug resistance. Therefore, polycarpol (1), three C-benzylated flavanones (2-4), and acetylmelodorinol (5) were evaluated for their multidrug resistance-reverting activity on methicillin-susceptible and methicillin-resistant Staphylococcus aureus and Escherichia coli AG100 and AG100 A strains overexpressing and lacking the AcrAB-TolC efflux pump system...
February 21, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29464362/inhibitory-mechanism-on-combination-of-phytic-acid-with-methanolic-seed-extract-of-syzygium-cumini-and-sodium-chloride-over-bacillus-subtilis
#10
Alok Kumar Yadav, Preeti Sirohi, Saurabh Saraswat, Manjoo Rani, Manish Pratap Singh, Sameer Srivastava, Nand K Singh
The antibiotic resistance in bacteria responsible for causing community and health care-associated infection displayed a major threat to global health. Use of broad-spectrum antibiotics for the treatment of various ailments poses serious side effects. In the present research, we investigated the combined role of 2% phytic acid with 2% methanolic seed extract of Syzygium cumini and 0.5% sodium chloride for inhibition of Bacillus subtilis and Pseudomonas aeruginosa and found it to be efficient over B. subtilis...
February 20, 2018: Current Microbiology
https://www.readbyqxmd.com/read/29464325/detection-and-cell-sorting-of-pseudonocardia-species-by-fluorescence-in-situ-hybridization-and-flow-cytometry-using-16s-rrna-targeted-oligonucleotide-probes
#11
Mengyan Li, Yu Yang, Ya He, Jacques Mathieu, Cong Yu, Qilin Li, Pedro J J Alvarez
Pseudonocardia spp. are receiving increasing attention due to their ability to biodegrade recalcitrant cyclic ether pollutants (e.g., 1,4-dioxane and tetrahydrofuran), as well as for their distinctive ecological niches (e.g., symbiosis with ants/plants and production of antibiotics). Isolating and characterizing Pseudonocardia spp. is thus important to discern their metabolic and physiological idiosyncrasies and advance their potential applications. However, slow growth, low cell yield, and dissimilar colony morphology hinder efficient isolation of Pseudonocardia using conventional plating methods...
February 21, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29463605/phenazines-regulate-nap-dependent-denitrification-in-pseudomonas-aeruginosa-biofilms
#12
Yu-Cheng Lin, Matthew D Sekedat, William Cole Cornell, Gustavo M Silva, Chinweike Okegbe, Alexa Price-Whelan, Christine Vogel, Lars E P Dietrich
Microbes in biofilms face the challenge of substrate limitation. In particular, cells in Pseudomonas aeruginosa biofilms growing in the laboratory or during host colonization often become limited for oxygen. Previously we found that phenazines, antibiotics produced by P. aeruginosa , balance the intracellular redox state for cells in biofilms. Here, we show that genes involved in denitrification are induced in phenazine-null (Δ phz ) mutant biofilms grown under an aerobic atmosphere, even in the absence of nitrate...
February 20, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29463546/treatment-with-atorvastatin-provides-additional-benefits-to-imipenem-in-a-model-of-gram-negative-pneumonia-induced-by-klebsiella-pneumoniae-in-mice
#13
Talles Prosperi de Paula, Patrícia Campi Santos, Raquel Duque do Nascimento Arifa, Angélica T Vieira, Ludmila de Matos Baltazar, Thiago Vinícius Ávila, Caio Tavares Fagundes, Zélia Menezes Garcia, Renata Lacerda Lima, Mauro Martins Teixeira, Danielle G Souza
The clinical pathogen Klebsiella pneumoniae is a relevant cause of nosocomial infections and resistance to current treatment with carbapenem antibiotics is becoming a significant problem. Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) used for controlling plasma cholesterol levels. There is clinical evidence showing other effects of statins, including decrease of lung inflammation. In the current study, we show that pretreatment with atorvastatin markedly attenuated lung injury, which was correlated with a reduction in the cellular influx into the alveolar space and lungs and down-modulation of the production of pro-inflammatory mediators in the initial phase of infection in C57BL/6 mice with K...
February 20, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29463543/mesoscopic-energy-minimization-drives-pseudomonas-aeruginosa-biofilm-morphologies-and-consequent-stratification-of-antibiotic-activity-based-on-cell-metabolism
#14
M V Sheraton, K H Yam, C H Tan, H S Oh, E Mancini, L Yang, S A Rice, P M A Sloot
Segregation of bacteria based on their metabolic activity in biofilms plays an important role in the development of antibiotic drug resistance. Mushroom-shaped biofilm structures, which are reported for many bacteria, exhibit topographically varying levels of multiple drug resistance from the cap of the mushroom to its stalk. Understanding the dynamics behind the formation of such structures can aid in design of drug delivery systems, antibiotics, or physical systems for removal of biofilms. We explore the development of metabolically heterogenous Pseudomonas aeruginosa biofilms using numerical models and laboratory knock-out experiments on wild-type and chemotaxis deficient mutants...
February 20, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29463447/novel-inhibitors-of-staphylococcus-aureus-rnpa-that-synergize-with-mupirocin
#15
Nicole Lounsbury, Tess Eidem, Jennifer Colquhoun, George Mateo, Magid Abou-Gharbia, Paul M Dunman, Wayne E Childers
We recently discovered RnpA as a promising new drug discovery target for methicillin-resistant S. aureus (MRSA). RnpA is an essential protein that is thought to perform two required cellular processes. As part of the RNA degrasome Rnpa mediates RNA degradation. In combination with rnpB it forms RNase P haloenzymes which are required for tRNA maturation. A high throughput screen identified RNPA2000 as an inhibitor of both RnpA-associated activities that displayed antibacterial activity against clinically relevant strains of S...
January 31, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29462728/treatment-of-lumbar-discitis-using-silicon-nitride-spinal-spacers-a-case-series-and-literature-review
#16
William M Rambo
INTRODUCTION: Septic infection of a lumbar intervertebral disc is a serious disorder which is often difficult to diagnose and appropriately treat because of the rarity of the disease, the varied presentation of symptoms, and the frequency of low-back pain within the overall population. Its etiology can be pyogenic, granulomatous, fungal, or parasitic; its incidence is rising due to increased patient susceptibility and improved diagnostic tools. Conservative treatments involve antibiotics, physical therapy, and/or immobilization...
February 10, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29462695/a-3d-intestinal-tissue-model-supports-clostridioides-difficile-germination-colonization-toxin-production-and-epithelial-damage
#17
Lamyaa Shaban, Ying Chen, Alyssa C Fasciano, Yinan Lin, David L Kaplan, Carol A Kumamoto, Joan Mecsas
Endospore-forming Clostridioides difficile is a causative agent of antibiotic-induced diarrhea, a major nosocomial infection. Studies of its interactions with mammalian tissues have been hampered by the fact that C. difficile requires anaerobic conditions to survive after spore germination. We recently developed a bioengineered 3D human intestinal tissue model and found that low O2 conditions are produced in the lumen of these tissues. Here, we compared the ability of C. difficile spores to germinate, produce toxin and cause tissue damage in our bioengineered 3D tissue model versus in a 2D transwell model in which human cells form a polarized monolayer...
February 17, 2018: Anaerobe
https://www.readbyqxmd.com/read/29462679/novel-ph-sensitive-dual-drug-loaded-gelatin-methacrylate-methacrylic-acid-hydrogel-for-the-controlled-release-of-antibiotics
#18
Thayyath Sreenivasan Anirudhan, Anila Manasa Mohan
The aim of the present study was to develop a novel pH sensitive gelatin methacrylate hydrogel for the controlled delivery of Gentamicin (GS) and Ampicillin (Amp). GS and Amp having synergistic activity is effective in killing multi drug resistant bacteria. The hydrogel was well characterized using FTIR, XRD and SEM techniques. The drug loading and encapsulation efficiency were found to be 85.0 and 77.0% for GS, 79.0 and 88.0% for Amp, respectively. The invitro swelling, degradation and release profiles suggest the pH dependent behaviour of hydrogel...
February 17, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29460278/structural-and-metabolic-responses-of-staphylococcus-aureus-biofilms-to-hyperosmotic-and-antibiotic-stress
#19
Mia Mae Kiamco, Abdelrhman Mohamed, Patrick Reardon, Carrie Marean-Reardon, Wrya Moh Aframehr, Douglas R Call, Haluk Beyenal, Ryan Renslow
Biofilms alter their metabolism in response to environmental stress. This study explores the effect of a hyperosmotic agent-antibiotic treatment on the metabolism of Staphylococcus aureus biofilms through the use of nuclear magnetic resonance (NMR) techniques. To determine the metabolic activity of S. aureus, we quantified the concentrations of metabolites in spent medium using high-resolution NMR spectroscopy. Biofilm porosity, thickness, biovolume, and relative diffusion coefficient depth profiles were obtained using NMR microimaging...
February 20, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29460213/evaluating-the-probiotic-potential-of-lactobacillus-plantarum-strains-from-algerian-infant-feces-towards-the-design-of-probiotic-starter-cultures-tailored-for-developing-countries
#20
Chahira Gheziel, Pasquale Russo, Mattia Pia Arena, Giuseppe Spano, Hadda-Imene Ouzari, Omar Kheroua, Djamel Saidi, Daniela Fiocco, Hanane Kaddouri, Vittorio Capozzi
Lactobacilli naturally present in the neonatal gut are believed to be beneficial for the human hosts and are investigated as potential probiotics. In this study, we aimed to characterize six Lactobacillus plantarum strains derived from the feces of a breast-fed infant, for the development of new probiotic cultures. Our attention was focused on L. plantarum in reason of the presence, within such species, of both pro-technological and probiotic strains, i.e., a combination of particular interest to design tailored probiotic starter cultures for developing countries...
February 19, 2018: Probiotics and Antimicrobial Proteins
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