keyword
MENU ▼
Read by QxMD icon Read
search

Ski cancer

keyword
https://www.readbyqxmd.com/read/27922162/nonmelanoma-skin-cancer-in-mountain-guides-high-prevalence-and-lack-of-awareness-warrant-development-of-evidence-based-prevention-tools
#1
Alexander Zink, Elisabeth Koch, Florian Seifert, Markus Rotter, Christoph D Spinner, Tilo Biedermann
AIMS OF THE STUDY: Nonmelanoma skin cancer (NMSC) is the most common cancer in Switzerland and Europe. The main causative factor is exposure to ultraviolet radiation, which puts outdoor workers in general at a higher risk of developing NMSC than indoor workers. However, few studies have clinically examined the risk of developing NMSC to outdoor workers, especially mountain guides. We aimed to investigate the prevalence of NMSC and corresponding precancerous lesions, and the associated risk behaviour of mountain and ski guides in order to develop future prevention programmes...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27909446/functional-toxicogenomic-profiling-expands-insight-into-modulators-of-formaldehyde-toxicity-in-yeast
#2
Matthew North, Brandon D Gaytán, Carlos Romero, Vanessa Y De La Rosa, Alex Loguinov, Martyn T Smith, Luoping Zhang, Chris D Vulpe
Formaldehyde (FA) is a commercially important chemical with numerous and diverse uses. Accordingly, occupational and environmental exposure to FA is prevalent worldwide. Various adverse effects, including nasopharyngeal, sinonasal, and lymphohematopoietic cancers, have been linked to FA exposure, prompting designation of FA as a human carcinogen by U.S. and international scientific entities. Although the mechanism(s) of FA toxicity have been well studied, additional insight is needed in regard to the genetic requirements for FA tolerance...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27904661/a-novel-sphingosine-kinase-1-inhibitor-ski-5c-induces-cell-death-of-wilms-tumor-cells-in-vitro-and-in-vivo
#3
Zhi-Heng Li, Yan-Fang Tao, Li-Xiao Xu, He Zhao, Xiao-Lu Li, Fang Fang, Yi Wu, Jun Lu, Yan-Hong Li, Wei-Wei Du, Jun-Li Ren, Yi-Ping Li, Yun-Yun Xu, Xing Feng, Jian Wang, Wei-Qi He, Jian Pan
Sphingosine kinase 1 (SphK1) is over-expressed in many cancers and therefore serves as a biomarker for cancer prognosis. SKI-5C is a new SphK1 inhibitor, and until now its molecular function in Wilms' tumor cells remained unknown. Here, using CCK-8 and nude mice experiments we assessed cell growth in Wilms' tumor cell lines (SK-NEP-1 and G401) in vitro and in vivo. We demonstrated that SphK1 is highly expressed in SK-NEP-1 and G401 cells, and through annexin V/propidium iodide staining and flow cytometry analysis, we detected cell apoptosis...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27902484/depletion-of-mitochondrial-reactive-oxygen-species-downregulates-epithelial-to-mesenchymal-transition-in-cervical-cancer-cells
#4
Galina Shagieva, Lidiya Domnina, Olga Makarevich, Boris Chernyak, Vladimir Skulachev, Vera Dugina
In the course of cancer progression, epithelial cells often acquire morphological and functional characteristics of mesenchymal cells, a process known as epithelial-to-mesenchymal transition (EMT). EMT provides epithelial cells with migratory, invasive, and stem cell capabilities. Reactive oxygen species produced by mitochondria (mtROS) could be of special importance for pro-tumorigenic signaling and EMT.In our study, we used mitochondria-targeted antioxidant SkQ1 to lower the mtROS level and analyze their role in the regulation of the actin cytoskeleton, adhesion junctions, and signaling pathways critical for tumorigenesis of cervical carcinomas...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27734340/ski-modulate-the-characteristics-of-pancreatic-cancer-stem-cells-via-regulating-sonic-hedgehog-signaling-pathway
#5
Libin Song, Xiangyuan Chen, Song Gao, Chenyue Zhang, Chao Qu, Peng Wang, Luming Liu
Evidence from in vitro and in vivo studies shows that Ski may act as both a tumor proliferation-promoting factor and a metastatic suppressor in human pancreatic cancer and also may be a therapeutic target of integrative therapies. At present, pancreatic cancer stem cells (CSCs) are responsible for tumor recurrence accompanied by resistance to conventional therapies. Sonic hedgehog (Shh) signaling pathway is found to be aberrantly activated in CSCs. The objectives of this study were to investigate the role of Ski in modulating pancreatic CSCs and to examine the molecular mechanisms involved in pancreatic cancer treatment both in vivo and in vitro...
October 12, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27729078/chalepin-isolated-from-ruta-angustifolia-l-pers-induces-mitochondrial-mediated-apoptosis-in-lung-carcinoma-cells
#6
Jaime Stella Moses Richardson, Gautam Sethi, Guan Serm Lee, Sri Nurestri Abdul Malek
BACKGROUND: Cancer has been one of the leading causes of mortality in this era. Ruta angustifolia L. Pers has been traditionally used as an abortifacient, antihelmintic, emmenagogue and ophthalmic. In Malaysia and Singapore, the local Chinese community used it for the treatment of cancer. METHODS: In this study, the methanol and fractionated extracts (hexane, chloroform, ethyl acetate and water) of R. angustifolia were tested for its cytotoxicity using the sulforhodamide (SRB) cytotoxicity assay against HCT-116, A549, Ca Ski and MRC5 cell lines...
October 12, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27435765/-phosphorylation-of-ezrin-tyr477-is-critical-in-invasion-of-breast-cancer-cells-stimulated-by-precursor-of-nerve-growth-factor
#7
Fu-Xi Li, Wen-Feng Shao, Rui Tang, Xiao-Ran Yu, Qiao-Sheng Wen, Yan-Lin Yu, Jing-Bo Xiong
OBJECTIVE: To investigate the effect of precursor of nerve growth factor (proNGF) in promoting invasion of breast cancer cells and its relation with ezrin expression and phosphorylation of ezrin Thr567 and Tyr477. METHODS: Human breast cancer cell lines MDA-MB-231 and MCF-7 were stimulated by gradient concentrations of proNGF (0, 2.5, 5 and 10 ng/mL) for 16 h, and the invasion of the cells was assessed with Transwell assay. The expression of ezrin and the phosphorylation of ezrin Thr567 and ezrin Tyr477 in the treated cells were examined by Western blotting...
June 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27430247/snon-suppresses-tgf-%C3%AE-induced-epithelial-mesenchymal-transition-and-invasion-of-bladder-cancer-in-a-tif1%C3%AE-dependent-manner
#8
Xinbao Yin, Chuanshen Xu, Xueping Zheng, Huiyang Yuan, Ming Liu, Yue Qiu, Jun Chen
The transcriptional regulator SnoN (also known as SKI-like proto-oncogene, SKIL), a member of the Ski family, has been reported to influence epithelial-mesenchymal transition (EMT) in response to TGF-β. In the present study, we investigated the role of SnoN in bladder cancer (BC). Differential expression of SnoN was not detected in BC tissues compared with that noted in adjacent non-cancerous tissues. SnoN was upregulated in response to TGF-β treatment, but had no effect on the TGF-β pathway, which may be explained by the low level of SnoN SUMOylation...
September 2016: Oncology Reports
https://www.readbyqxmd.com/read/27137215/identification-of-key-regulators-of-pancreatic-cancer-progression-through-multidimensional-systems-level-analysis
#9
Deepa Rajamani, Manoj K Bhasin
BACKGROUND: Pancreatic cancer is an aggressive cancer with dismal prognosis, urgently necessitating better biomarkers to improve therapeutic options and early diagnosis. Traditional approaches of biomarker detection that consider only one aspect of the biological continuum like gene expression alone are limited in their scope and lack robustness in identifying the key regulators of the disease. We have adopted a multidimensional approach involving the cross-talk between the omics spaces to identify key regulators of disease progression...
2016: Genome Medicine
https://www.readbyqxmd.com/read/27045164/health-related-quality-of-life-during-bosutinib-ski-606-therapy-in-patients-with-advanced-chronic-myeloid-leukemia-after-imatinib-failure
#10
Jennifer Whiteley, Arlene Reisman, Mark Shapiro, JorgeE Cortes, David Cella
OBJECTIVES: The tyrosine kinase inhibitor (TKI) bosutinib has demonstrated activity in patients with advanced phase chronic myeloid leukemia (CML), but effects on health-related quality of life (HRQoL) remain unexplored. This study evaluated HRQoL in advanced CML patients receiving bosutinib in an ongoing phase 2 study following resistance or intolerance to prior imatinib therapy. METHODS: This analysis included data from 76 accelerated-phase (AP) and 64 blast-phase (BP) patients resistant/intolerant to prior imatinib with or without prior exposure to other TKIs...
August 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/26992657/the-metabolic-profiles-of-pterin-compounds-as-potential-biomarkers-of-bladder-cancer-integration-of-analytical-based-approach-with-biostatistical-methodology
#11
Piotr Kośliński, Emilia Daghir-Wojtkowiak, Paulina Szatkowska-Wandas, Marcin Markuszewski, Michał J Markuszewski
Cancer disease is the second leading cause of death across the world. The analysis of potential biomarkers of cancer can be useful in cancer screening or cancer diagnosis, and may provide valuable information on the disease risk and progression. Pterin compounds have been studied as candidates of potential biomarkers as their elevated levels have been reported in various cancer diseases. The objective of the study was to compare the profiles of six pterin compounds in urine of 35 healthy subjects and 46 patients diagnosed of bladder cancer with the use of HPLC coupled with fluorimetric detection...
August 5, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/26983446/the-impact-of-oophorectomy-on-survival-after-breast-cancer-in-brca1-positive-breast-cancer-patients
#12
T Huzarski, T Byrski, J Gronwald, C Cybulski, O Oszurek, M Szwiec, K Gugała, M Stawicka, Z Morawiec, T Mierzwa, M Falco, H Janiszewska, E Kilar, E Marczyk, B Kozak-Klonowska, M Siołek, D Surdyka, R Wiśniowski, M Posmyk, P Domagała, P Sun, J Lubiński, S A Narod
The aim of the study is to identify treatments which predict survival for women with a BRCA1 mutation, including oophorectomy and chemotherapy. 476 women with stage I to stage III breast cancer who carried a BRCA1 mutation were followed from diagnosis until April 2015. Information on treatment was obtained from chart review and patient questionnaires. Dates of death were obtained from the Poland vital statistics registry. Survival curves were compared for different subgroups according to treatment received...
April 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/26969570/spinal-tuberculosis-with-severe-neurological-symptoms-as-a-complication-of-intravesical-bcg-therapy-for-carcinoma-of-the-bladder
#13
Jerzy Białecki, Mirosława Nowak-Misiak, Kazimierz Rąpała, Wojciech Marczyński, Gracjan Suchodolski, Aleksandra Truszczyńska
INTRODUCTION: Non-invasive bladder cancer is effectively treated with intravesical BCG therapy. The administration of the BCG vaccine is to destroy the neoplastic lesion or prevent further recurrences. The activity of the vaccine involves boosting the immune system through the stimulation of the inflammation in the bladder. Adverse reactions after this immunotherapy are rare. The aim of the study was to present complications in the form of spinal tuberculosis and serious neurological symptoms that occurred during intravesical BCG immunotherapy for carcinoma of the bladder...
2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/26959551/methods-for-preliminary-determination-of-pemetrexed-in-macromolecular-drug-carrier-systems
#14
Jarosław Ciekot, Tomasz Marek Goszczyński, Janusz Boratyński
Pemetrexed (PMX) is an antifolate drug utilized in the treatment of non-small cell lung cancer. For studies of potential macromolecular carriers for PMX, fast and precise methods were developed to determine the bound and free drug contained in investigated conjugate preparations. The analysis of the total amount of PMX in conjugates was based on absorption spectrophotometry. The linearity was found in the range of 4.697-46.97 μmol L(-1) PMX. The limit of quantitation was 1.070 μmol L(-1). The method for the analysis of unbound PMX was based on size-exclusion chromatography and detection at 225 nm...
March 2016: Acta Pharmaceutica
https://www.readbyqxmd.com/read/26948869/the-hmgb1-protein-induces-a-metabolic-type-of-tumour-cell-death-by-blocking-aerobic-respiration
#15
Georg Gdynia, Sven W Sauer, Jürgen Kopitz, Dominik Fuchs, Katarina Duglova, Thorsten Ruppert, Matthias Miller, Jens Pahl, Adelheid Cerwenka, Markus Enders, Heimo Mairbäurl, Marcin M Kamiński, Roland Penzel, Christine Zhang, Jonathan C Fuller, Rebecca C Wade, Axel Benner, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister, Hanswalter Zentgraf, Peter Schirmacher, Wilfried Roth
The high-mobility group box 1 (HMGB1) protein has a central role in immunological antitumour defense. Here we show that natural killer cell-derived HMGB1 directly eliminates cancer cells by triggering metabolic cell death. HMGB1 allosterically inhibits the tetrameric pyruvate kinase isoform M2, thus blocking glucose-driven aerobic respiration. This results in a rapid metabolic shift forcing cells to rely solely on glycolysis for the maintenance of energy production. Cancer cells can acquire resistance to HMGB1 by increasing glycolysis using the dimeric form of PKM2, and employing glutaminolysis...
March 7, 2016: Nature Communications
https://www.readbyqxmd.com/read/26944438/sphk1-inhibitor-ski-ii-inhibits-the-proliferation-of-human-hepatoma-hepg2-cells-via-the-wnt5a-%C3%AE-catenin-signaling-pathway
#16
Hong Liu, Cai-Xia Zhang, Yan Ma, Hong-Wei He, Jia-Ping Wang, Rong-Guang Shao
AIM: Sphingosine 1-phosphate (S1P) promotes cell growth, proliferation and survival. Sphingosine kinase 1 (SphK1), which converts sphingosine to S1P, is a key promoter in cancer. We previously found that the SphK1 inhibitor II (SKI II), suppresses the cell growth and induces apoptosis in human hepatoma HepG2 cells. However, the precise regulatory mechanism and signaling pathway on SKI II inhibiting tumor growth remains unknown. MAIN METHODS: The expressions of β-catenin and related molecules of Wnt/β-catenin signal were detected by western blot in HepG2 cells...
April 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/26934645/proteasomal-degradation-of-sphingosine-kinase-1-and-inhibition-of-dihydroceramide-desaturase-by-the-sphingosine-kinase-inhibitors-ski-or-abc294640-induces-growth-arrest-in-androgen-independent-lncap-ai-prostate-cancer-cells
#17
Melissa McNaughton, Melissa Pitman, Stuart M Pitson, Nigel J Pyne, Susan Pyne
Sphingosine kinases (two isoforms termed SK1 and SK2) catalyse the formation of the bioactive lipid sphingosine 1-phosphate. We demonstrate here that the SK2 inhibitor, ABC294640 (3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide) or the SK1/SK2 inhibitor, SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole)) induce the proteasomal degradation of SK1a (Mr = 42 kDa) and inhibit DNA synthesis in androgen-independent LNCaP-AI prostate cancer cells. These effects are recapitulated by the dihydroceramide desaturase (Des1) inhibitor, fenretinide...
March 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/26926303/the-role-of-otolaryngologist-head-and-neck-surgeon-s-in-the-treatment-of-thyroid-cancer
#18
Marcin Sówka, Anna Wegner, Ewa Majchrzak, Wojciecj Golusiński
Thyroid gland is an integral part of the neck region. In the topographic anatomy of the head and neck the gland is located in the middle triangle of the neck. Therefore, it is an organ which is also subject for diagnostic and treatment by otorhinolaryngologists - head and neck surgeons. Material and methods The study group consists of 50 patients aged from 22 to 76 years (mean 48). All patients were treated for suspected thyroid tumor. The ratio of women to men was 35:15. In all patients the same panel of diagnostic tests was used including: endocrinologic consultation, ENT examination with stroboscopic examination with assessment of vocal cord mobility, neck ultrasound examination to assess the thyroid gland and lymph nodes...
February 29, 2016: Otolaryngologia Polska. the Polish Otolaryngology
https://www.readbyqxmd.com/read/26921593/pentoxifylline-affects-idarubicin-binding-to-dna
#19
Grzegorz Gołuński, Agnieszka Borowik, Andrea Lipińska, Monika Romanik, Natalia Derewońko, Anna Woziwodzka, Jacek Piosik
Anticancer drug idarubicin - derivative of doxorubicin - is commonly used in treatment of numerous cancer types. However, in contrast to doxorubicin, its biophysical properties are not well established yet. Additionally, potential direct interactions of idarubicin with other biologically active aromatic compounds, such as pentoxifylline - representative of methylxanthines - were not studied at all. Potential formation of such hetero-aggregates may result in sequestration of the anticancer drug and, in consequence, reduction of its biological activity...
April 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/26918391/n-%C3%AF-chloroacetyl-l-ornithine-has-in-vitro-activity-against-cancer-cell-lines-and-in-vivo-activity-against-ascitic-and-solid-tumors
#20
Alba L Vargas-Ramírez, Miriam M Medina-Enríquez, Neira I Cordero-Rodríguez, Tatiana Ruiz-Cuello, Leopoldo Aguilar-Faisal, José G Trujillo-Ferrara, Verónica Alcántara-Farfán, Lorena Rodríguez-Páez
N-ω-chloroacetyl-L-ornithine (NCAO) is an ornithine decarboxylase (ODC) inhibitor that is known to exert cytotoxic and antiproliferative effects on three neoplastic human cancer cell lines (HeLa, MCF-7, and HepG2). Here, we show that NCAO has antiproliferative activity in 13 cancer cell lines, of diverse tissue origin from human and mice, and in a mouse cancer model in vivo. All cell lines were sensitive to NCAO after 72 h of treatment (the EC50 ranged from 1 to 50.6 µmol/l). The Ca Ski cell line was the most sensitive (EC50=1...
July 2016: Anti-cancer Drugs
keyword
keyword
96948
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"