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https://www.readbyqxmd.com/read/28811702/precision-medicine-in-need-of-guidance-and-surveillance
#1
EDITORIAL
Jian-Zhen Lin, Jun-Yu Long, An-Qiang Wang, Ying Zheng, Hai-Tao Zhao
Precision medicine, currently a hotspot in mainstream medicine, has been strongly promoted in recent years. With rapid technological development, such as next-generation sequencing, and fierce competition in molecular targeted drug exploitation, precision medicine represents an advance in science and technology; it also fulfills needs in public health care. The clinical translation and application of precision medicine - especially in the prevention and treatment of tumors - is far from satisfactory; however, the aims of precision medicine deserve approval...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28810960/talk-to-the-hand-u-s-army-biophysical-testing
#2
William R Santee, Adam W Potter, Karl E Friedl
BACKGROUND: Many people are unaware of the science underlying the biophysical properties of Soldier clothing and personal protective equipment, yet there is a well-refined biomedical methodology initiated by Army physiologists in World War II. This involves a methodical progression of systematic material testing technologies, computer modeling, and human testing that enables more efficient development and rapid evaluation of new concepts for Soldier health and performance. Sophisticated manikins that sweat and move are a central part of this testing continuum...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810806/evaluating-structural-change-approaches-to-health-promotion-an-exploratory-scoping-review-of-a-decade-of-u-s-progress
#3
Yuka Asada, Lisa D Lieberman, Leah C Neubauer, Rosie Hanneke, Michael C Fagen
Structural change approaches-also known as policy and environmental changes-are becoming increasingly common in health promotion, yet our understanding of how to evaluate them is still limited. An exploratory scoping review of the literature was conducted to understand approaches and methods used to evaluate structural change interventions in health promotion and public health literature. Two analysts-along with health sciences librarian consultation-searched PubMed, Web of Science, and EMBASE for peer-reviewed U...
August 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28810508/anticipating-the-nature-the-future-in-environmental-science-introduction-to-the-virtual-special-issue
#4
EDITORIAL
Rocco Scolozzi, Alessandro Gretter, Emanuele Eccel
No abstract text is available yet for this article.
August 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28809473/aie-materials-with-different-electric-charges-as-artificial-tongue-design-construction-and-assembly-with-various-pathogenic-bacteria-for-effective-bacterial-imaging-and-discrimination
#5
Guang-Jian Liu, Sheng-Nan Tian, Cui-Yun Li, Guo-Wen Xing, Lei Zhou
Imaging-based total bacterial count and type identification of bacteria play crucial rules in clinical diagnostics, public health, biological and medical science, environmental protection. Herein, we designed and synthesized a series of tetraphenylethenes (TPEs) functionalized with one or two aldehyde, carboxylic acid and quaternary ammonium groups, which were successfully used as fluorescent materials for rapid and efficient staining of 8 kinds of representative bacterial species, including pathogenic bacteria Vibrio cholera, Klebsiella pneumoniae, Listeria monocytogenes and potential bioterrorism agent Yersinia pestis...
August 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28808561/quantifying-the-degree-of-bias-from-using-county-scale-data-in-species-distribution-modeling-can-increasing-sample-size-or-using-county-averaged-environmental-data-reduce-distributional-overprediction
#6
Steven D Collins, John C Abbott, Nancy E McIntyre
Citizen-science databases have been used to develop species distribution models (SDMs), although many taxa may be only georeferenced to county. It is tacitly assumed that SDMs built from county-scale data should be less precise than those built with more accurate localities, but the extent of the bias is currently unknown. Our aims in this study were to illustrate the effects of using county-scale data on the spatial extent and accuracy of SDMs relative to true locality data and to compare potential compensatory methods (including increased sample size and using overall county environmental averages rather than point locality environmental data)...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28806362/harnessing-implementation-science-to-increase-the-impact-of-health-equity-research
#7
Matthew Chinman, Eva N Woodward, Geoffrey M Curran, Leslie R M Hausmann
BACKGROUND: Health disparities are differences in health or health care between groups based on social, economic, and/or environmental disadvantage. Disparity research often follows 3 steps: detecting (phase 1), understanding (phase 2), and reducing (phase 3), disparities. Although disparities have narrowed over time, many remain. OBJECTIVES: We argue that implementation science could enhance disparities research by broadening the scope of phase 2 studies and offering rigorous methods to test disparity-reducing implementation strategies in phase 3 studies...
September 2017: Medical Care
https://www.readbyqxmd.com/read/28806234/delirium-in-the-critically-ill-child
#8
Sharon Norman, Asma A Taha, Helen N Turner
PURPOSE/OBJECTIVE: The purposes of this article are to describe the scientific literature on assessment, prevention, and management of delirium in critically ill children and to articulate the implications for clinical nurse specialists, in translating the evidence into practice. DESCRIPTION: A literature search was conducted in 4 databases-OvidMEDLINE, Cumulative Index to Nursing and Allied Health Literature, PsychINFO, and Web of Science-using the terms "delirium," "child," and "critically ill" for the period of 2006 to 2016...
September 2017: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/28799745/a-two-distinctly-separated-emission-colorimetric-nir-fluorescent-probe-for-fast-hydrazine-detection-in-living-cells-and-mice-upon-independent-excitations
#9
Zhengliang Lu, Wenlong Fan, Xiaomin Shi, Yanan Lu, Chunhua Fan
Hydrazine is carcinogenic and highly toxic so that it can lead to serious environmental contamination and serious health risks although it has been extensively used as an effective propellant and an important reactive base in industry. Thus, the development of two-emission NIR fluorescent probes for rapid detection of hydrazine with high selectivity and sensitivity is of significance and of great challenge in both biological and environmental sciences. Here, we report a two-emission colori-metric fluorescent probe for the specific detection of hydrazine based on hydrazinolysis reaction under physiological condi-tions...
August 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28799488/environment-and-neurodegenerative-diseases-an-update-on-mirna-role
#10
Margherita Ferrante, Gea Oliveri Conti
INTRODUCTION: The importance of neurodegenerative diseases on the management of public health is growing and the real role of the environment and miRNA in their occurrence is still unclear. miRNA can affect significantly the regulatory network. The complex variety and gene-regulatory capacity of miRNAs is particularly valuable in the brain, being a very complex organ with a functional specialization of neurons highly adaptable to environmental stimuli. In particular a miRNAs role is demonstrated in neurological diseases as the effect to toxic and mutagenic substances exposure by the environment...
August 11, 2017: MicroRNA
https://www.readbyqxmd.com/read/28799245/when-and-where-to-move-dynamic-occupancy-models-explain-the-range-dynamics-of-a-food-nomadic-bird-under-climate-and-land-cover-change
#11
Riddhika Kalle, Tharmalingam Ramesh, Colleen T Downs
Globally, long-term research is critical to monitor the responses of tropical species to climate and land cover change at the range scale. Citizen science surveys can reveal the long-term persistence of poorly known nomadic tropical birds occupying fragmented forest patches. We applied dynamic occupancy models to 13 years (2002-2014) of citizen science driven presence/absence data on Cape parrot (Poicephalus robustus), a food nomadic bird endemic to South Africa. We modelled its underlying range dynamics as a function of resource distribution, and change in climate and land cover through the estimation of colonization and extinction patterns...
August 11, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28796768/emm-type-distribution-of-group-a-streptococcus-isolates-from-the-throat-swabs-of-children-living-in-areas-with-a-high-northland-and-gisborne-or-low-palmerston-north-incidence-of-acute-rheumatic-fever
#12
Noah Mhlanga, Grace Sharp, Mary Nulsen
AIM: To assess the circulating emm types of pharyngeal isolates of group A streptococcus (GAS) among school children living in Northland, the Gisborne region and Palmerston North, New Zealand. METHODS: GAS were isolated from throat swabs sent to laboratories in Northland (197 in 2013) and Gisborne (115 in 2014-15) and from children enrolled in the Palmerston North Solar Ventilation Project (70 in 2013-14). The incidences of acute rheumatic fever (ARF) cases in the three regions in 2014 were 9, 19...
August 11, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28796216/environmental-science-trends-in-ecosystem-recovery-from-drought
#13
Sonia I Seneviratne, Philippe Ciais
No abstract text is available yet for this article.
August 9, 2017: Nature
https://www.readbyqxmd.com/read/28795874/lack-of-association-between-the-p413l-variant-of-chromogranin-b-and-als-risk-or-age-at-onset-a-meta-analysis
#14
Xinglong Yang, Shimei Li, Dongmei Xing, Peiyun Li, Ci Li, Ling Qi, Yanming Xu, Hui Ren
BACKGROUND: Amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, is thought to result from interaction of genetic and environmental risk factors. Whether the potentially functional exonic P413L variant in the chromogranin B gene influences ALS risk and age at onset is controversial. METHOD: We meta-analysed or other studies assessing the association between the P413L variant and ALS risk or age at ALS onset indexed in Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed databases...
August 10, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28792755/the-dynamics-and-kinetics-of-water-interactions-with-a-condensed-nopinone-surface
#15
Sofia M Johansson, Xiangrui Kong, Erik S Thomson, Mattias Hallquist, Jan B C Pettersson
Water and organic molecules are omnipresent in the environment and their interactions are of central importance in many Earth system processes. Here we investigate molecular-level interactions between water and a nopinone surface using an environmental molecular beam (EMB) technique. Nopinone is a major reaction product formed during oxidation of β-pinene, a prominent compound emitted by coniferous trees, which has been found in both the gas and particle phases of atmospheric aerosol. The EMB method enables detailed studies of the dynamics and kinetics of D2O molecules interacting with a solid nopinone surface at 202 K...
August 9, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28792517/comparison-of-alternative-approaches-for-analysing-multi-level-rna-seq-data
#16
Irina Mohorianu, Amanda Bretman, Damian T Smith, Emily K Fowler, Tamas Dalmay, Tracey Chapman
RNA sequencing (RNA-seq) is widely used for RNA quantification in the environmental, biological and medical sciences. It enables the description of genome-wide patterns of expression and the identification of regulatory interactions and networks. The aim of RNA-seq data analyses is to achieve rigorous quantification of genes/transcripts to allow a reliable prediction of differential expression (DE), despite variation in levels of noise and inherent biases in sequencing data. This can be especially challenging for datasets in which gene expression differences are subtle, as in the behavioural transcriptomics test dataset from D...
2017: PloS One
https://www.readbyqxmd.com/read/28792022/ambient-mass-spectrometry-in-metabolomics
#17
REVIEW
Chaevien S Clendinen, María Eugenia Monge, Facundo M Fernández
Since the introduction of desorption electrospray ionization (DESI) mass spectrometry (MS), ambient MS methods have seen increased use in a variety of fields from health to food science. Increasing its popularity in metabolomics, ambient MS offers limited sample preparation, rapid and direct analysis of liquids, solids, and gases, in situ and in vivo analysis, and imaging. The metabolome consists of a constantly changing collection of small (<1.5 kDa) molecules. These include endogenous molecules that are part of primary metabolism pathways, secondary metabolites with specific functions such as signaling, chemicals incorporated in the diet or resulting from environmental exposures, and metabolites associated with the microbiome...
August 9, 2017: Analyst
https://www.readbyqxmd.com/read/28792002/in-vitro-human-skin-permeation-of-benzene-in-gasoline-effects-of-concentration-multiple-dosing-and-skin-preparation
#18
H Frederick Frasch, Ana M Barbero
In vitro human skin benzene permeation was measured from gasoline formulations with benzene concentrations ranging from 0.8 to 10 vol% and from neat benzene. Steady-state fluxes (JSS), permeability coefficients (kp) and lag times (tlag) were calculated from infinite dose exposures. Permeation of benzene from small gasoline doses administered over a two-day period was also studied. The thermodynamic activity of benzene in gasoline at 30 °C was determined and the solution is near-ideal over the range from 0...
August 9, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28782932/visualization-of-colloidal-nanocrystal-formation-and-electrode-electrolyte-interfaces-in-liquids-using-tem
#19
Zhiyuan Zeng, Wenjing Zheng, Haimei Zheng
Transmission electron microscopy (TEM) has become a powerful analytical tool for addressing unique scientific problems in chemical sciences as well as in materials sciences and other disciplines. There has been a lot of recent interest in the development and applications of liquid phase environmental TEM. In this Account, we review the development and applications of liquid cell TEM for the study of dynamic phenomena at liquid-solid interfaces, focusing on two areas: (1) nucleation, growth, and self-assembly of colloidal nanocrystals and (2) electrode-electrolyte interfaces during charge and discharge processes...
August 7, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28779765/profragrance-chemistry-as-an-interdisciplinary-research-area-and-key-technology-for-fragrance-delivery
#20
Andreas Herrmann
Profragrances or properfumes are important delivery systems for the controlled release of volatile compounds. They constitute an essential part of a series of commercial body care and household products to ensure the long-lastingness of perfume perception in practical application. Fragrances are released from their respective precursors by covalent bond cleavage under mild environmental conditions. Originating from organic chemistry, modern profragrance research has evolved to a truly interdisciplinary research area covering supramolecular science, physical chemistry, analytical chemistry and various aspects of materials science...
August 9, 2017: Chimia
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