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https://www.readbyqxmd.com/read/29149702/an-hplc-tandem-mass-spectrometry-for-quantification-of-et-26-hcl-and-its-major-metabolite-in-plasma-and-application-to-a-pharmacokinetic-study-in-rats
#1
Xu Chen, Wensheng Zhang, Sandy Rios, Miriam B Morkos, Xiaoli Ye, Gen Li, Xuehua Jiang, Zhijun Wang, Ling Wang
ET-26-HCl is a new analog of etomidate, a short-acting anesthetic drug, with less adrenal cortex inhibition. The pharmacokinetics of ET-26-HCl in rats needs to be determined for future clinical trials in human subjects. In order to facilitate the pharmacokinetic study, a liquid chromatography based tandem mass spectrometric (HPLC-MS/MS) method was developed and validated for quantification of ET-26-HCl and its major metabolite, ET-26-acid. These two compounds and gabapentin (internal standard) were extracted using a protein precipitation method with methanol and detected by Multiple Reaction Monitoring of m/z transition of 275...
November 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29149560/the-extended-zinc-amber-force-field-ezaff
#2
Zhuoqin Yu, Pengfei Li, Kenneth M Merz
An empirical approach based on the previously developed zinc AMBER force field (ZAFF) is proposed for the determination of the parameters for bonds and angles involving zinc. We call it the extended ZAFF (EZAFF) model because the original ZAFF model was only formulated for 4-coordinated systems, while EZAFF additionally can tackle 5- and 6-coordinated systems. Tests were carried out for 6 metalloproteins and 5 organometallic compounds with different coordination spheres. Results validated the reliability of the current model to handle a variety of zinc containing complexes...
November 17, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29149546/the-photophysical-and-photoacoustic-properties-of-quadrupolar-borondifluoride-curcuminoid-dyes
#3
Stephanie Bellinger, Maryam Hatamimoslehabadi, Seema Bag, Farha Mithila, Jeffrey La, Mathieu Frennete, Samir Laoui, David Szalda, Chandra Yelleswarapu, Jonathan Rochford
The synthesis and characterization of a series of donor-π-acceptor-π-donor (D-A-D) curcuminoid molecules are here presented incorporating π-extended aryl and electron-donating amino terminal functionalization. Computational evaluation shows these molecules possess quadrupolar character with the lowest energy transitions displaying high molar extinction coefficients with broad tunability through manipulation of terminal donating groups. Consistent with their quadrupolar nature, these molecules show varying degrees of solvatochromic behavior in both their absorption and emission spectra which has been analyzed by Lippert-Mataga and Kamlet-Taft analysis...
November 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29149411/elusive-role-of-tctp-protein-and-mrna-in-cell-cycle-and-cytoskeleton-regulation
#4
Jacek Z Kubiak, Malgorzata Kloc
Translationally Controlled Tumor-associated Protein (TCTP) is a small, 23 kDa multifunctional and ubiquitous protein localized both in the cytoplasm and in the nucleus of eukaryotic cells. It is evolutionarily highly conserved. Certain aspects of its structure show remarkable similarities to guanine nucleotide-free chaperons Mss4 and Dss4 suggesting that at least some functions of TCTP may depend on its chaperon-like action on other proteins. Besides other functions, TCTP is clearly involved in cell cycle regulation...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/29149264/sim3c-simulation-of-hi-c-and-meta3c-proximity-ligation-sequencing-technologies
#5
Matthew Z DeMaere, Aaron E Darling
Background: Chromosome conformation capture (3C) and Hi-C DNA sequencing methods have rapidly advanced our understanding of the spatial organization of genomes and metagenomes. Many variants of these protocols have been developed, each with their own strengths. Currently there is no systematic means for simulating sequence data from this family of sequencing protocols, potentially hindering the advancement of algorithms to exploit this new datatype. Findings: We describe a computational simulator that, given simple parameters and reference genome sequences, will simulate Hi-C sequencing on those sequences...
November 15, 2017: GigaScience
https://www.readbyqxmd.com/read/29149240/z-scores-based-methods-and-their-application-to-biological-monitoring-an-example-in-professional-soccer-players
#6
Guillaume Saulière, Jérôme Dedecker, Laurie-Anne Marquet, Pierre Rochcongar, Jean-Francois Toussaint, Geoffroy Berthelot
The clinical and biological follow-up of individuals, such as the biological passport for athletes, is typically based on the individual and longitudinal monitoring of hematological or urine markers. These follow-ups aim to identify abnormal behavior by comparing the individual's biological samples to an established baseline. These comparisons may be done via different ways, but each of them requires an appropriate extra population to compute the significance levels, which is a non-trivial issue. Moreover, it is not necessarily relevant to compare the measures of a biomarker of a professional athlete to that of a reference population (even restricted to other athletes), and a reasonable alternative is to detect the abnormal values by considering only the other measurements of the same athlete...
November 15, 2017: Biostatistics
https://www.readbyqxmd.com/read/29149227/synthesis-of-z-alkenes-via-visible-light-promoted-photocatalytic-e-%C3%A2-z-isomerization-under-metal-free-conditions
#7
Wenbin Cai, Huaqiang Fan, Dazhong Ding, Yongqiang Zhang, Wei Wang
A green approach for the synthesis of thermodynamically less stable Z-alkenes has been presented through the exploration of visible light promoted photocatalytic E-to-Z isomerization. This protocol features metal-free conditions, which is operationally simple, remarkably clean, and allows the synthesis of both electron-rich and electron-deficient Z-alkenes with diverse functional groups.
November 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29149197/sieve-analysis-of-breakthrough-hiv-1-sequences-in-hvtn-505-identifies-vaccine-pressure-targeting-the-cd4-binding-site-of-env-gp120
#8
Allan C deCamp, Morgane Rolland, Paul T Edlefsen, Eric Sanders-Buell, Breana Hall, Craig A Magaret, Andrew J Fiore-Gartland, Michal Juraska, Lindsay N Carpp, Shelly T Karuna, Meera Bose, Steven LePore, Shana Miller, Annemarie O'Sullivan, Kultida Poltavee, Hongjun Bai, Kalpana Dommaraju, Hong Zhao, Kim Wong, Lennie Chen, Hasan Ahmed, Derrick Goodman, Matthew Z Tay, Raphael Gottardo, Richard A Koup, Robert Bailer, John R Mascola, Barney S Graham, Mario Roederer, Robert J O'Connell, Nelson L Michael, Merlin L Robb, Elizabeth Adams, Patricia D'Souza, James Kublin, Lawrence Corey, Daniel E Geraghty, Nicole Frahm, Georgia D Tomaras, M Juliana McElrath, Lisa Frenkel, Sheila Styrchak, Sodsai Tovanabutra, Magdalena E Sobieszczyk, Scott M Hammer, Jerome H Kim, James I Mullins, Peter B Gilbert
Although the HVTN 505 DNA/recombinant adenovirus type 5 vector HIV-1 vaccine trial showed no overall efficacy, analysis of breakthrough HIV-1 sequences in participants can help determine whether vaccine-induced immune responses impacted viruses that caused infection. We analyzed 480 HIV-1 genomes sampled from 27 vaccine and 20 placebo recipients and found that intra-host HIV-1 diversity was significantly lower in vaccine recipients (P ≤ 0.04, Q-values ≤ 0.09) in Gag, Pol, Vif and envelope glycoprotein gp120 (Env-gp120)...
2017: PloS One
https://www.readbyqxmd.com/read/29149191/resting-state-fmri-in-sleeping-infants-more-closely-resembles-adult-sleep-than-adult-wakefulness
#9
Anish Mitra, Abraham Z Snyder, Enzo Tagliazucchi, Helmut Laufs, Jed Elison, Robert W Emerson, Mark D Shen, Jason J Wolff, Kelly N Botteron, Stephen Dager, Annette M Estes, Alan Evans, Guido Gerig, Heather C Hazlett, Sarah J Paterson, Robert T Schultz, Martin A Styner, Lonnie Zwaigenbaum, Bradley L Schlaggar, Joseph Piven, John R Pruett, Marcus Raichle
Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs...
2017: PloS One
https://www.readbyqxmd.com/read/29149177/new-brain-lesions-with-no-impact-on-physical-disability-can-impact-cognition-in-early-multiple-sclerosis-a-ten-year-longitudinal-study
#10
D Wybrecht, F Reuter, F Pariollaud, W Zaaraoui, A Le Troter, A Rico, S Confort-Gouny, E Soulier, M Guye, A Maarouf, J-P Ranjeva, J Pelletier, B Audoin
OBJECTIVE: In early multiple sclerosis, although brain T2 lesions accrual are hallmark of the disease, only weak correlations were found between T2 lesions accrual and EDSS progression, the disability scale commonly used in multiple sclerosis studies. This may be related to the very poor sensitivity of EDSS to cognitive dysfunctions that may occur and progress from the first stage of the disease. In the present study, we aimed to demonstrate that cognitive deficits progress during the first ten years of MS and are significantly impacted by new T2 lesions...
2017: PloS One
https://www.readbyqxmd.com/read/29149140/optimization-of-postoperative-intravenous-patient-controlled-analgesia-with-opioid-dexmedetomidine-combinations-an-updated-meta-analysis-with-trial-sequential-analysis-of-randomized-controlled-trials
#11
Ke Peng, Juan Zhang, Xiao-Wen Meng, Hua-Yue Liu, Fu-Hai Ji
BACKGROUND: It is still a challenge to optimize postoperative pain management. The effects of adding dexmedetomidine (DEX) to opioid-based postoperative intravenous patient-controlled analgesia (PCA) are not fully understood. OBJECTIVES: The aim of this study is to assess the efficacy and safety of opioid-DEX combinations for postoperative PCA, and a trial sequential analysis (TSA) is utilized to evaluate the robustness of the current evidence. STUDY DESIGN: A systematic review and meta-analysis...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29149118/perceived-self-efficacy-a-concept-analysis-for-symptom-management-in-patients-with-cancer%C3%A2
#12
Lynn L White, Marlene Z Cohen, Ann M Berger, Kevin A Kupzyk, Barbara A Swore-Fletcher, Philip J Bierman
BACKGROUND: Perceived self-efficacy (PSE) for symptom management plays a key role in outcomes for patients with cancer, such as quality of life, functional status, symptom distress, and healthcare use. Definition of the concept is necessary for use in research and to guide the development of interventions to facilitate PSE for symptom management in patients with cancer.
. OBJECTIVES: This analysis will describe the concept of PSE for symptom management in patients with cancer...
December 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29149080/novel-tactile-sensor-technology-and-smart-tactile-sensing-systems-a-review
#13
REVIEW
Liang Zou, Chang Ge, Z Jane Wang, Edmond Cretu, Xiaoou Li
During the last decades, smart tactile sensing systems based on different sensing techniques have been developed due to their high potential in industry and biomedical engineering. However, smart tactile sensing technologies and systems are still in their infancy, as many technological and system issues remain unresolved and require strong interdisciplinary efforts to address them. This paper provides an overview of smart tactile sensing systems, with a focus on signal processing technologies used to interpret the measured information from tactile sensors and/or sensors for other sensory modalities...
November 17, 2017: Sensors
https://www.readbyqxmd.com/read/29148967/group-b-streptococcus-infections-caused-by-improper-sourcing-and-handling-of-fish-for-raw-consumption-singapore-2015-2016
#14
Man L Chau, Swaine L Chen, Min Yap, Sri H P Hartantyo, Paul K T Chiew, Charlene J Fernandez, Wai K Wong, Rockey K Fong, Wei L Tan, Brian Z Y Tan, Youming Ng, Kyaw T Aung, Kurosh S Mehershahi, Christopher Goh, Joanne S L Kang, Timothy Barkham, Adeline O K Leong, Ramona A Gutiérrez, Lee C Ng
We assessed microbial safety and quality of raw fish sold in Singapore during 2015-2016 to complement epidemiologic findings for an outbreak of infection with group B Streptococcus serotype III sequence type (ST) 283 associated with raw fish consumption. Fish-associated group B Streptococcus ST283 strains included strains nearly identical (0-2 single-nucleotide polymorphisms) with the human outbreak strain, as well as strains in another distinct ST283 clade (57-71 single-nucleotide polymorphisms). Our investigations highlight the risk for contamination of freshwater fish (which are handled and distributed separately from saltwater fish sold as sashimi) and the need for improved hygienic handling of all fish for raw consumption...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29148802/ppb-peptide-mediated-sirna-loaded-stable-nucleic-acid-lipid-nanoparticles-on-targeting-therapy-of-hepatic-fibrosis
#15
Zongxiang Jia, Yan Gong, Yufang Pi, Xueying Liu, Lipeng Gao, Liqing Kang, Jing Wang, Fan Yang, Jie Tang, Weiyue Lu, Qinghua Li, Wei Zhang, Zhiqiang Yan, Lei Yu
Hepatic fibrosis is a necessary process in the development of liver diseases such as hepatic cirrhosis and its complications, which has become a serious threat to human health. Currently, antifibrotic drug treatment is ineffective, and one of the reasons should be the lack of liver targeting ability. In this report, polypeptide pPB modified stable nucleic acid lipid nanoparticles (pPB-SNALP) were prepared to selectively deliver siRNAs against heat shock protein 47 (HSP47) to liver for targeted therapy of hepatic fibrosis...
November 17, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29148759/exploring-the-mechanism-and-stereoselectivity-in-chiral-cinchona-catalyzed-hetero-dimerization-of-ketenes
#16
Bangaru Bhaskararao, Garima Jindal, Raghavan B Sunoj
Catalytic hetero-dimerization of ketenes can lead to important four membered β-lactones. A recent asymmetric organocatalytic [2+2] cycloaddition between methylketene (MK) and methylphenylketene (MPK) in the presence of pseudo-enantiomeric cinchona catalysts (trimethylsilyl quinine (TMSQ) or methyl quinidine (MeQd)) provided β-lactones with high enantio- and diastereo-selectivities. We employ DFT(M06-2X) computations to understand the mechanism and the origin of stereoselectivity in this ketene hetero-dimerization...
November 17, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29148742/identification-of-the-peptide-pyroq-%C3%AE-casein194-209-as-a-highly-specific-and-sensitive-marker-to-differentiate-between-ultrahigh-temperature-processed-uht-milk-and-mildly-heated-milk
#17
Sevim Dalabasmaz, Jennifer Ebner, Monika Pischetsrieder
In this study, a new approach was introduced to identify marker peptides that reflect the thermal treatment of commercial milk samples and differentiate ultrahigh-temperature processed (UHT) milk from mildly heated milk. Peptide profiles of training set samples, pasteurized (n=20), extended shelf life (n=29), and UHT (n=29) milk, were recorded by MALDI-TOF-MS after StageTip micro-extraction. As marker candidates, 13 peptides were selected and their cutoff levels were defined. The quality of the cutoff levels was then tested with a blind test set...
November 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29148525/differences-in-photoreceptor-recovery-among-patients-and-between-different-parts-of-the-posterior-pole-in-vogt-koyanagi-harada-disease
#18
M Zhou, R P Gu, Z Sun, C H Jiang, Q Chang, G Z Xu
PurposeTo investigate the recovery of photoreceptors following the treatment in Vogt-Koyanagi-Harada (VKH) disease.Patients and methodsThis was a retrospective study. We enrolled 28 patients with VKH (56 eyes). The clinical and optical coherence tomography (OCT) findings were recorded for 12 months after treatment. The patterns of photoreceptor recovery on OCT were defined: pattern F group=Foveal photoreceptor recovery visible first; pattern E group=Extrafoveal photoreceptor recovery visible first; and pattern S group=Simultaneous foveal and extrafoveal photoreceptor recovery...
November 17, 2017: Eye
https://www.readbyqxmd.com/read/29148338/comprehensive-support-for-family-caregivers-impact-on-veteran-health-care-utilization-and-costs
#19
Courtney Harold Van Houtven, Valerie A Smith, Karen M Stechuchak, Megan Shepherd-Banigan, Susan Nicole Hastings, Matthew L Maciejewski, Gilbert Darryl Wieland, Maren K Olsen, Katherine E M Miller, Margaret Kabat, Jennifer Henius, Margaret Campbell-Kotler, Eugene Z Oddone
This study aimed to examine the early impact of the Program of Comprehensive Assistance for Family Caregivers (PCAFC) on Veteran health care utilization and costs. A pre-post cohort design including a nonequivalent control group was used to understand how Veterans' use of Veteran Affairs health care and total health care costs changed in 6-month intervals up to 3 years after PCAFC enrollment. The control group was an inverse probability of treatment weighted sample of Veterans whose caregivers applied for, but were not accepted into, PCAFC...
March 1, 2017: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/29148299/treatment-of-leachate-from-municipal-solid-waste-of-mostaganem-district-in-algeria-decision-support-for-advising-a-process-treatment
#20
Z Bourechech, F Abdelmalek, M R Ghezzar, A Addou
The aim of this work is to propose a plan for the choice of a suitable process for the treatment of a young leachate from municipal solid waste. Classical processes were applied: Fenton process, the coupling coagulation-Fenton process and the adsorption on powdered activated carbon (PAC). The study involves synthesised leachates from three types of wastes collected from sanitary landfill (SL): leachate of putrescible fraction (Lp), paper-cardboard (Lpc), sawdust (Ls) and the one of landfill (Lsl). The optimal operating conditions have been determined for the three processes: Fenton: [H2O2] = 6...
November 1, 2017: Waste Management & Research
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