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https://www.readbyqxmd.com/read/27936436/spectroscopic-single-crystal-x-ray-hirshfeld-in-vitro-and-in-silico-biological-evaluation-of-a-new-series-of-potent-thiazole-nucleus-integrated-with-pyrazoline-scaffolds
#1
Vinutha V Salian, Badiadka Narayana, Balladka K Sarojini, Madan S Kumar, Govinahalli S Nagananda, Kullaiah Byrappa, Avinash K Kudva
In the present study, the spectroscopic characterization of a new series of substituted thiazole linked pyrazoline scaffolds 4a-l was performed. The formation of 4a-l from the intermediate 3-(4-chlorophenyl)-5-[4-(propan-2-yl)phenyl]-4,5-dihydro-1H-pyrazole-1-carbothioamide 2 and substituted 2-bromo-1-phenylethanone 3a-l was evidenced through the changes in FTIR, (1)H NMR, (13)C NMR, LCMS data. The X-ray diffraction studies revealed that compound 2 and 4g crystallized in monoclinic crystal system with P21/n space group...
November 28, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27936295/variability-of-pinus-halepensis-mill-essential-oils-and-their-antioxidant-activities-depending-on-the-stage-of-growth-during-vegetative-cycle
#2
Zineb Djerrad, Abderrahmane Djouahri, Leila Kadik
The impact of growth stages during vegetative cycle (B0 -B5 ) on chemical composition and antioxidant activities of Pinus halepensis Mill. needles essential oils was investigated for the first time. GC and GC-MS analyses pointed to a quantitative variability of components; terpene hydrocarbons derivatives, represented by α-pinene (8.5-12.9%), myrcene (17.5-21.6%), p-cymene (7.9-11.9%) and (Z)-β-caryophyllene (17.3-21.2%) as major components, decreased from 88.9% at B0 growth stage to 66.9% at B5 growth stage, whereas oxygenated derivatives, represented by caryophyllene oxide (5...
December 9, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27936190/two-isoforms-of-yersinia-pestis-plasminogen-activator-pla-intraspecies-distribution-intrinsic-disorder-propensity-and-contribution-to-virulence
#3
Svetlana V Dentovskaya, Mikhail E Platonov, Tat'yana E Svetoch, Pavel Kh Kopylov, Tat'yana I Kombarova, Sergey A Ivanov, Rima Z Shaikhutdinova, Lyubov' V Kolombet, Sadhana Chauhan, Vitaly G Ablamunits, Vladimir L Motin, Vladimir N Uversky, Andrey P Anisimov
It has been shown previously that several endemic Y. pestis isolates with limited virulence contained the I259 isoform of the outer membrane protease Pla, while the epidemic highly virulent strains possessed only the T259 Pla isoform. Our sequence analysis of the pla gene from 118 Y. pestis subsp. microtus strains revealed that the I259 isoform was present exclusively in the endemic strains providing a convictive evidence of more ancestral origin of this isoform. Analysis of the effects of the I259T polymorphism on the intrinsic disorder propensity of Pla revealed that the I259T mutation slightly increases the intrinsic disorder propensity of the C-terminal tail of Pla and makes this protein slightly more prone for disorder-based protein-protein interactions, suggesting that the T259 Pla could be functionally more active than the I259 Pla...
2016: PloS One
https://www.readbyqxmd.com/read/27936172/tamoxifen-isomers-and-metabolites-exhibit-distinct-affinity-and-activity-at-cannabinoid-receptors-potential-scaffold-for-drug-development
#4
Benjamin M Ford, Lirit N Franks, Anna Radominska-Pandya, Paul L Prather
Tamoxifen (Tam) is a selective estrogen receptor (ER) modulator (SERM) that is an essential drug to treat ER-positive breast cancer. Aside from known actions at ERs, recent studies have suggested that some SERMs like Tam also exhibit novel activity at cannabinoid subtype 1 and 2 receptors (CB1R and CB2Rs). Interestingly, cis- (E-Tam) and trans- (Z-Tam) isomers of Tam exhibit over a 100-fold difference in affinity for ERs. Therefore, the current study assessed individual isomers of Tam and subsequent cytochrome P450 metabolic products, 4-hydroxytamoxifen (4OHT) and 4-hydroxy-N-desmethyl tamoxifen (End) for affinity and activity at CBRs...
2016: PloS One
https://www.readbyqxmd.com/read/27936111/sediment-properties-as-important-predictors-of-carbon-storage-in-zostera-marina-meadows-a-comparison-of-four-european-areas
#5
Martin Dahl, Diana Deyanova, Silvia Gütschow, Maria E Asplund, Liberatus D Lyimo, Ventzislav Karamfilov, Rui Santos, Mats Björk, Martin Gullström
Seagrass ecosystems are important natural carbon sinks but their efficiency varies greatly depending on species composition and environmental conditions. What causes this variation is not fully known and could have important implications for management and protection of the seagrass habitat to continue to act as a natural carbon sink. Here, we assessed sedimentary organic carbon in Zostera marina meadows (and adjacent unvegetated sediment) in four distinct areas of Europe (Gullmar Fjord on the Swedish Skagerrak coast, Askö in the Baltic Sea, Sozopol in the Black Sea and Ria Formosa in southern Portugal) down to ~35 cm depth...
2016: PloS One
https://www.readbyqxmd.com/read/27936096/factors-associated-with-disability-in-rural-bangladesh-bangladesh-population-based-diabetes-and-eye-study-bpdes
#6
Fakir M Amirul Islam, Jahar L Bhowmik, Silvia Z Islam, Andre M N Renzaho, Janet E Hiller
BACKGROUND: To assess factors associated with disability in a rural district of Bangladesh. METHODS: Using a population-based systematic sampling technique, data were collected from 3104 adults aged ≥ 30 years from the Banshgram union of Narail district. Data collected included an interviewer administered questionnaire to report physical disabilities including impairment that prevents engagement with paid work, visual, hearing, and mobility as well as mental disabilities...
2016: PloS One
https://www.readbyqxmd.com/read/27936001/computerized-analysis-of-verbal-fluency-normative-data-and-the-effects-of-repeated-testing-simulated-malingering-and-traumatic-brain-injury
#7
David L Woods, John M Wyma, Timothy J Herron, E William Yund
In verbal fluency (VF) tests, subjects articulate words in a specified category during a short test period (typically 60 s). Verbal fluency tests are widely used to study language development and to evaluate memory retrieval in neuropsychiatric disorders. Performance is usually measured as the total number of correct words retrieved. Here, we describe the properties of a computerized VF (C-VF) test that tallies correct words and repetitions while providing additional lexical measures of word frequency, syllable count, and typicality...
2016: PloS One
https://www.readbyqxmd.com/read/27935974/epigallocatechin-3-gallate-upregulates-mir-221-to-inhibit-osteopontin-dependent-hepatic-fibrosis
#8
M L Arffa, M A Zapf, A N Kothari, V Chang, G N Gupta, X Ding, M M Al-Gayyar, W Syn, N M Elsherbiny, P C Kuo, Z Mi
Osteopontin (OPN) promotes hepatic fibrosis, and developing therapies targeting OPN expression in settings of hepatic injury holds promise. The polyphenol epigallocatechin-3-gallate (EGCG), found in high concentrations in green tea, downregulates OPN expression through OPN mRNA degradation, but the mechanism is unknown. Previous work has shown that microRNAs can decrease OPN mRNA levels, and other studies have shown that EGCG modulates the expression of multiple microRNAs. In our study, we first demonstrated that OPN induces hepatic stellate cells to transform into an activated state...
2016: PloS One
https://www.readbyqxmd.com/read/27935927/molecular-identification-of-extended-spectrum-%C3%AE-lactamase-and-integron-genes-in-klebsiella-pneumonia
#9
E Estabraghi, T Z Salehi, K Amini, M Jamshidian
INTRODUCTION: Infections caused by Gram negative bacteria, producing extended-spectrum β-lactamase, including Klebsiella pneumoniae are increasing all over the world with high morbidity and mortality. The aim of the present study was determined antimicrobial profile susceptibility and the prevalence of antibiotic resistance genes by multiplex PCR. METHODS: In the present study, we obtained one-hundred isolates of K. pneumoniae from different clinical samples. The antibiotic susceptibility testing was done in thirteen antibiotic and, therefore, M-PCRs were conducted using the DNA amplification for detection of ESBLs (blaTEM, blaCTX-M, blaSHV) and int (I, II, III) genes...
April 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935793/co-occurring-risk-factors-in-multiple-sclerosis
#10
Julia M Balto, Ipek Ensari, Elizabeth A Hubbard, Naiman Khan, Jennifer L Barnes, Robert W Motl
OBJECTIVE: We examined individual and co-occurring risk factors as correlates of health outcomes in persons with multiple sclerosis (MS). METHODS: Sixty-nine participants with MS completed measures of nutrition, physical activity levels, comorbidity and neuroperformance. The data were analyzed using t-test analyses in SPSS Statistics 22.0. RESULTS: Total number of comorbidities (z = 2.36, p = .02), cardiovascular disease symptoms (z = 2.63, p = ...
January 2017: American Journal of Health Behavior
https://www.readbyqxmd.com/read/27935705/aroma-active-compounds-in-bartlett-pears-and-their-changes-during-the-manufacturing-process-of-bartlett-pear-brandy
#11
Bianca Zierer, Peter Schieberle, Michael Granvogl
Application of aroma extract dilution analysis to Bartlett pears and the fermented mash produced thereof revealed 24 and 34 aroma-active compounds in the flavor dilution (FD) factor range between 8 and 8192. Twenty-eight compounds, which have not been described before in Bartlett pears or in fermented pear mash, were identified. While ethyl (E,Z)-2,4-decadienoate (pear-like, metallic odor impression), hexyl acetate (green, fruity), and acetic acid (vinegar-like) showed the highest concentrations in Bartlett pears, ethanol (ethanolic), acetic acid, 3-methyl-1-butanol (malty), 1-hexanol (grassy, marzipan-like), (S)-2- and 3-methylbutanoic acid (sweaty), and 2-phenylethanol (flowery, honey-like) were present at the highest amounts in the fermented mash...
December 9, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27935594/plant-mediated-horizontal-transmission-of-wolbachia-between-whiteflies
#12
Shao-Jian Li, Muhammad Z Ahmed, Ning Lv, Pei-Qiong Shi, Xing-Min Wang, Ji-Lei Huang, Bao-Li Qiu
Maternal transmission is the main transmission pathway of facultative bacterial endosymbionts, but phylogenetically distant insect hosts harbor closely related endosymbionts, suggesting that horizontal transmission occurs in nature. Here we report the first case of plant-mediated horizontal transmission of Wolbachia between infected and uninfected Bemisia tabaci AsiaII7 whiteflies. After infected whiteflies fed on cotton leaves, Wolbachia was visualized, both in the phloem vessels and in some novel 'reservoir' spherules along the phloem by fluorescence in situ hybridization using Wolbachia-specific 16S rRNA probes and transmission electron microscopy...
December 9, 2016: ISME Journal
https://www.readbyqxmd.com/read/27935591/coupled-molecular-and-isotopic-evidence-for-denitrifier-controls-over-terrestrial-nitrogen-availability
#13
Erin F E Lennon, Benjamin Z Houlton
Denitrification removes ecologically available nitrogen (N) from the biosphere and influences both the pace and magnitude of global climate change. Disagreements exist over the degree to which this microbial process influences N-availability patterns across Earth's ecosystems. We combine natural stable isotope methods with qPCR to investigate how denitrifier gene abundance is related to variations in nitrate (NO3(-)) pool sizes across diverse terrestrial biomes and conditions. We analyze NO3(-) isotope composition ((15)N/(14)N, (18)O/(16)O) and denitrifier gene nirS in 52 soil samples from different California ecosystems, spanning desert, chaparral, oak-woodland/savanna and forest...
December 9, 2016: ISME Journal
https://www.readbyqxmd.com/read/27935577/bone-marrow-fibrosis-grade-is-an-independent-risk-factor-for-overall-survival-in-patients-with-primary-myelofibrosis
#14
B Li, P Zhang, G Feng, Z Xu, T Qin, Y Zhang, Z Sha, D Dong, H Zhang, L Fang, L Pan, N Hu, S Qu, W Cai, G Huang, Z Xiao
No abstract text is available yet for this article.
December 9, 2016: Blood Cancer Journal
https://www.readbyqxmd.com/read/27935203/solution-chemistry-of-n-n-disubstituted-amidines-identification-of-isomers-and-evidence-for-linear-dimer-formation
#15
Kai F Kalz, Anja Hausmann, Sebastian Dechert, Steffen Meyer, Michael John, Franc Meyer
Amidines have found widespread use, but their solution chemistry remains poorly understood. In this work, X-ray crystallographic and detailed 1D and 2D NMR spectroscopic studies have been performed to elucidate the preferred isomers and their interconversion mechanisms. Amidines are shown to exist as a mixture of E-syn and Z-anti isomers in solution and to form dimeric H-bonded aggregates that are also observed in the solid state. Rapid proton exchange/tautomerization reactions occur within the dimers, allowing fast interconversion of E-syn and Z-anti isomers even at very low temperatures...
December 12, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27935194/unconventional-reactivity-of-z-enoate-propargylic-alcohols-in-presence-of-acids
#16
Beeraiah Baire, Prabhakararao Tharra
Unconventional reactivity of z-enoate attached propargylic alcohols in presence of acids (nucleophilic as well as non-nucleophilic) has been described. This study lead to the discovery and development of a novel strategy for the collective synthesis of synthetically useful building blocks -chloro-, -mesyloxy-, -tosyloxy-enones and 4,5-dioxonoates. The reaction is very mild and general in terms of substrate scope.
December 9, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27935150/trends-in-potentially-inappropriate-medication-prescribing-to-nursing-home-patients-comparison-of-three-cross-sectional-studies
#17
Kjell H Halvorsen, Geir Selbaek, Sabine Ruths
PURPOSE: The aim of this study was to examine trends in potentially inappropriate medication (PIM) prescribing in Norwegian nursing homes. METHODS: Patients aged ≥70 years were included from three cross-sectional studies conducted in 1997, 2005 and 2011. PIMs were analyzed according to the Norwegian General Practice-Nursing Home criteria (NORGEP-NH), use of single substances to avoid, combinations to avoid, and deprescribing items. Associations between sample and use of PIMs were examined by logistic regression, adjusted for age, gender, and ward...
December 9, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27935088/shifts-in-the-distribution-of-ixodid-ticks-parasitizing-cattle-in-zimbabwe
#18
M Sungirai, E N Abatih, D Z Moyo, P De Clercq, M Madder
In an attempt to update information on the ecological distribution of ixodid ticks (Ixodida: Ixodidae) in Zimbabwe, a cross-sectional survey was carried out between September 2013 and May 2015 at 322 dip tanks. A total of 15 tick species were collected, namely: Amblyomma hebraeum Koch (65.2%, n = 210/322), Amblyomma variegatum Fabricius (14.9%, n = 48/322), Hyalomma rufipes Koch (62.4%, n = 201/322), Hyalomma truncatum Koch (37.9%, n = 122/322), Rhipicephalus appendiculatus Neumann (60.6%, n = 195/322), Rhipicephalus compositus Neumann (0...
December 9, 2016: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/27934994/determination-of-the-thermal-oxidative-and-photochemical-degradation-rates-of-scintillator-liquid-by-fluorescence-eem-spectroscopy
#19
N L P Andrews, J Z Fan, R L Forward, M C Chen, H-P Loock
The thermal, oxidative and photochemical stability of the scintillator liquid proposed for the SNO+ experiment has been tested experimentally using accelerated aging methods. The stability of the scintillator constituents was determined through fluorescence excitation emission matrix (EEM) spectroscopy and absorption spectroscopy, using parallel factor analysis (PARAFAC) as an multivariate analysis tool. By exposing the scintillator liquid to a well-known photon flux at 365 nm and by measuring the decay rate of the fluorescence shifters and the formation rate of their photochemical degradation products, we can place an upper limit on the acceptable photon flux as 1...
December 9, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27934883/preclinical-evaluation-of-radiation-and-systemic-rgd-targeted-adeno-associated-virus-phage-tnf-gene-therapy-in-a-mouse-model-of-spontaneously-metastatic-melanoma
#20
T J Quinn, N Healy, A Sara, E Maggi, C S Claros, R Kabarriti, L Scandiuzzi, L Liu, J Gorecka, A Adem, I Basu, Z Yuan, C Guha
The incidence of melanoma in the United States continues to rise, with metastatic lesions notoriously recalcitrant to therapy. There are limited effective treatment options available and a great need for more effective therapies that can be rapidly integrated in the clinic. In this study, we demonstrate that the combination of RGD-targeted adeno-associated virus phage (RGD-AAVP-TNF) with hypofractionated radiation therapy results in synergistic inhibition of primary syngeneic B16 melanoma in a C57 mouse model...
December 9, 2016: Cancer Gene Therapy
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