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https://www.readbyqxmd.com/read/29158918/challenges-with-surveillance-of-healthcare-associated-infections-in-intensive-care-units-in-south-africa
#1
Saajida Mahomed, Ozayr Mahomed, A Willem Sturm, Stephen Knight, Prashini Moodley
Background: The incidence of healthcare-associated infections (HAIs) in the public health sector in South Africa is not known due to the lack of a surveillance system. We report on the challenges experienced in the implementation of a surveillance system for HAIs in intensive care units (ICUs). Methods: A passive, paper-based surveillance system was piloted in eight ICUs to measure the incidence of ventilator-associated pneumonia, catheter-associated urinary tract infection, and central line-associated bloodstream infection...
2017: Critical Care Research and Practice
https://www.readbyqxmd.com/read/29158286/what-is-data-integrity
#2
Anil K Rattan
Data integrity has recently been in the regulatory agencies limelight. It is primarily due to increased number of inspections findings related to data integrity. Regulatory agencies have published many guidelines for industry to follow starting from 1963. AT that industry was using the completely paper-based system but due to the technology advancement, we are in electronic age. Most of the pharmaceutical industry is operating in the hybrid mode. It is clear that it started with basic regulations, then 21 CFR Part 11 and now ALCOA plus...
November 20, 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/29158131/development-of-a-low-cost-paper-based-elisa-method-for-rapid-escherichia-coli-o157-h7-detection
#3
REVIEW
Bo Pang, Chao Zhao, Li Li, Xiuling Song, Kun Xu, Juan Wang, Yushen Liu, Kaiyue Fu, Hao Bao, Dandan Song, Xiangjun Meng, Xiaofeng Qu, Zhuping Zhang, Juan Li
Escherichia coli O157: H7 (E. coli O157: H7) has become one of the most dangerous foodborne pathogenic bacteria around the world. Currently, because of the tedious, high-cost and stringent laboratory conditions required, the conventional E. coli O157: H7 detection methods, such as culture-based methods and polymerase chain reaction (PCR), have much limitation. Thus, we developed a novel paper-based enzyme-linked immunosorbent assay (p-ELISA) with shorter operation duration, lower cost, relatively higher sensitivity and wider application...
November 17, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29157182/do-surveys-with-paper-and-electronic-devices-differ-in-quality-and-cost-experience-from-the-rufiji-health-and-demographic-surveillance-system-in-tanzania
#4
Oscar Mukasa, Hildegalda P Mushi, Nicolas Maire, Amanda Ross, Don de Savigny
BACKGROUND: Data entry at the point of collection using mobile electronic devices may make data-handling processes more efficient and cost-effective, but there is little literature to document and quantify gains, especially for longitudinal surveillance systems. OBJECTIVE: To examine the potential of mobile electronic devices compared with paper-based tools in health data collection. METHODS: Using data from 961 households from the Rufiji Household and Demographic Survey in Tanzania, the quality and costs of data collected on paper forms and electronic devices were compared...
2017: Global Health Action
https://www.readbyqxmd.com/read/29157148/implementation-of-clinical-pharmacy-services-in-an-academic-oncology-practice-in-india
#5
Himanshu Patel, Parthasarathi Gurumurthy
Objective This study was conducted to investigate medication-related problems after implementation of clinical pharmacy services at a speciality oncology care setting. Methods It was a prospective interventional study conducted for a period of three years at a private academic oncology care setting. Paper-based medical records and medication orders were reviewed and patients and care givers were interviewed to understand the treatment plan. All the medication-related problems were identified by clinical pharmacists by performing drug therapy review...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29153947/paper-based-fluorogenic-devices-for-in-vitro-diagnostics
#6
REVIEW
Meirong Wu, Qiongyu Lai, Qiang Ju, Lin Li, Hai-Dong Yu, Wei Huang
In vitro diagnostics (IVD) are essential in healthcare systems for detection of diseases, conditions, or infections. Affordable and sensitive methods remain a challenge in the development of IVD. In this article, we give an overview of paper-based fluorogenic devices, an emerging cost-effective analytical method for IVD applications. The paper-based devices are inexpensive, sensitive, selective, user-friendly and equipment-free. Furthermore, the fluorescent detection on paper-based devices has recently attracted enormous attentions due to its high sensitivity and selectivity...
November 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29153858/an-evaluation-of-the-feedback-loops-in-the-poverty-focus-of-world-bank-operations
#7
Shahrokh Fardoust, Ravi Kanbur, Xubei Luo, Mark Sundberg
The World Bank Group in 2013 made the elimination of extreme poverty by 2030 a central institutional focus and purpose. This paper, based on an evaluation conducted by the Independent Evaluation Group of the World Bank Group, examines how, and how well, the Bank uses feedback loops to enhance the poverty focus of its operations. Feedback loops are important for every element of the results chain running from data, to diagnostics, to strategy formulation and finally to strategy implementation. The evaluation uses a range of instruments, including surveys of stakeholders and World Bank staff, focus group meetings, country case studies and systematic reviews of Bank lending and non-lending operations...
September 1, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29152029/portable-detection-of-trace-metals-in-airborne-particulates-and-sediments-via-%C3%AE-pads-and-smartphone
#8
Yuan Jia, Hui Dong, Jianping Zheng, Hao Sun
Particulate matter (PM), a key indicator of air pollution by natural and anthropogenic activities, contributes to a wide spectrum of diseases that lead to a shortening of life expectancy. It has been recognized that trace metals in airborne PM are highly toxic and can be correlated with lesion in respiratory, gastrointestinal, immunological, and hematological systems. Traditional methods for trace metal assay require sophisticated instrumentations and highly trained operators in centralized laboratories. In this work, by integrating the technologies of microfluidic paper-based analytical devices, additive manufacturing, smartphone, and colorimetric sensing, we developed the first smartphone based paper microfluidic platform for portable, disposable, and quantitative measurements of cobalt (Co), copper (Cu), and iron (Fe) in ambient air and street sediments...
November 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/29149990/simultaneous-determination-of-renal-function-biomarkers-in-urine-using-a-validated-paper-based-microfluidic-analytical-device
#9
Eduardo Luiz Rossini, Maria Izabel Milani, Emanuel Carrilho, Leonardo Pezza, Helena Redigolo Pezza
In this paper, we describe a validated paper-based microfluidic analytical device for the simultaneous quantification of two important biomarkers of renal function in urine. This paper platform provides an inexpensive, simple, and easy to use colorimetric method for the quantification of creatinine (CRN) and uric acid (UA) in urine samples. The microfluidic paper-based analytical device (μPAD) consists of a main channel with three identical arms, each containing a circular testing zone and a circular uptake zone...
January 2, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29142037/elevated-psychosocial-stress-at-work-in-patients-with-systemic-lupus-erythematosus-and-rheumatoid-arthritis
#10
Jutta G Richter, Thomas Muth, Jian Li, Ralph Brinks, Gamal Chehab, Tobias Koch, Johannes Siegrist, Peter Angerer, Dörte Huscher, Matthias Schneider
OBJECTIVE: Psychosocial stress at work not only affects the healthy working population, but also workers with chronic diseases. We aimed to investigate the psychosocial work stress levels in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). METHODS: A cross-sectional study applied the Effort-Reward Imbalance (ERI) questionnaire - an internationally established instrument that measures work stress - to patients with SLE and RA who were capable of work and to a group of controls without these diseases...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29140434/managing-public-health-data-mobile-applications-and-mass-vaccination-campaigns
#11
Melissa W McClung, Sarah A Gumm, Megan E Bisek, Amber L Miller, Bryan C Knepper, Arthur J Davidson
In response to data collection challenges during mass immunization events, Denver Public Health developed a mobile application to support efficient public health immunization and prophylaxis activities. The Handheld Automated Notification for Drugs and Immunizations (HANDI) system has been used since 2012 to capture influenza vaccination data during Denver Health's annual employee influenza campaign. HANDI has supported timely and efficient administration and reporting of influenza vaccinations through standardized data capture and database entry...
November 13, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29138767/a-facile-method-for-urinary-phenylalanine-measurement-on-paper-based-lab-on-chip-for-pku-therapy-monitoring
#12
M A Messina, C Meli, S Conoci, S Petralia
A miniaturized paper-based lab-on-chip (LoC) was developed for the facile measurement of urinary Phe (phenylalanine) level on PKU (Phenylketonuria) treated patient. This system permits the monitoring of Phe in a dynamic range concentration of 20-3000 μM.
November 15, 2017: Analyst
https://www.readbyqxmd.com/read/29137708/smartphone-based-non-invasive-salivary-glucose-biosensor
#13
Anuradha Soni, Sandeep Kumar Jha
The present work deals with the development of a non-invasive optical glucose biosensor using saliva samples and a smartphone. The sensor was fabricated with a simple methodology by immobilization of Glucose oxidase enzyme along with a pH responsive dye on a filter paper based strip. The strip changes color upon reaction with glucose present in saliva and the color changes were detected using a smartphone camera through RGB profiling. This standalone biosensor showed good sensitivity and low interference while operating within 20 s response time...
December 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29137115/cost-effective-and-handmade-paper-based-immunosensing-device-for-electrochemical-detection-of-influenza-virus
#14
Sivaranjani Devarakonda, Renu Singh, Jyoti Bhardwaj, Jaesung Jang
Although many studies concerning the detection of influenza virus have been published, a paper-based, label-free electrochemical immunosensor has never been reported. Here, we present a cost-effective, handmade paper-based immunosensor for label-free electrochemical detection of influenza virus H1N1. This immunosensor was prepared by modifying paper with a spray of hydrophobic silica nanoparticles, and using stencil-printed electrodes. We used a glass vaporizer to spray the hydrophobic silica nanoparticles onto the paper, rendering it super-hydrophobic...
November 11, 2017: Sensors
https://www.readbyqxmd.com/read/29136843/improved-assessment-of-accuracy-and-performance-using-a-rotational-paper-based-device-for-multiplexed-detection-of-heavy-metals
#15
Xiange Sun, Bowei Li, Anjin Qi, Chongguo Tian, Jinglong Han, Yajun Shi, Bingcheng Lin, Lingxin Chen
In this work, a novel rotational microfluidic paper-based device was developed to improve the accuracy and performance of the multiplexed colorimetric detection by effectively avoiding the diffusion of colorimetric reagent on the detection zone. The integrated paper-based rotational valves were used to control the connection or disconnection between detection zones and fluid channels. Based on the manipulation of the rotational valves, this rotational paper-based device could prevent the random diffusion of colorimetric reagent and reduce the error of quantitative analysis considerably...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136828/compact-detectors-made-of-paired-leds-for-photometric-and-fluorometric-measurements-on-paper
#16
Marta Fiedoruk-Pogrebniak, Mateusz Granica, Robert Koncki
The utility of strikingly simple and cheap optoelectronic detectors operating according to a Paired-Emitter-Detector-Diode (PEDD) principle for microfluidic paper-based analytical devices (μPAD) has been experimentally confirmed. The prototypes of these compact detectors have been made of only two customary light emitting diodes without any additional optical parts like lens, filters, fibers etc. Moreover, for their operation economic and portable equipment is required (low-power circuit and ordinary voltmeter)...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136807/in-situ-gold-nanoparticle-electrogeneration-on-gold-films-deposited-on-paper-for-non-enzymatic-electrochemical-determination-of-glucose
#17
Estefanía Núnez-Bajo, M Carmen Blanco-López, Agustín Costa-García, M Teresa Fernández-Abedul
This work describes the development and evaluation of a new electrochemical platform based on the sustainable generation of gold-nanoparticles on paper-based gold-sputtered electrodes. The disposable porous paper electrode is combined with screen-printed electrodes for ensuring a precise electrogeneration of nanoparticles and also for the evaluation of these simple, versatile and low-cost microfluidic devices. Two types of chromatographic paper with different thicknesses have been evaluated. Paper gold working electrodes modified with gold nanoparticles were characterized by scanning electron microscopy and cyclic voltammetry using potassium ferrocyanide as a common redox probe, showing an improved electrochemical performance when compared to bare gold electrodes...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136803/simple-and-selective-paper-based-colorimetric-sensor-for-determination-of-chloride-ion-in-environmental-samples-using-label-free-silver-nanoprisms
#18
Abdulhadee Yakoh, Poomrat Rattanarat, Weena Siangproh, Orawon Chailapakul
Simple and selective paper-based colorimetric sensors using silver nanoprism (AgNPrs) were conveniently fabricated and developed for the determination of chloride ions (Cl(-)) contaminated in the environment. Samples containing different concentrations of Cl(-) were analyzed. The analysis is based on the oxidative etching of the AgNPrs into smaller silver nanospheres (AgNPss) by Cl(-). In the presence of Cl(-), the distinctive color change of the AgNPrs from dark-violet to red was rapidly visualized by the naked eye in 5min without the requirement of surface modification...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136800/polyamidoamine-starburst-dendrimer-activated-chromatography-paper-based-assay-for-sensitive-detection-of-telomerase-activity
#19
Hua Zhang, Zhen Lei, Rongrong Tian, Zhenxin Wang
Telomerase is extensively expressed in various cancer cells and recognized as a target for cancer drug discovery. In the present study, a simple and amplification-free fluorescence assay based on polyamidoamine starburst dendrimer (PAMAM dendrimer)-activated paper device is proposed for sensitive detection of telomerase activity through hybridization of Cy5 modified single strand DNA probes with telomerase extension products. The paper substrate is fabricated by hand drawing according to a template, which is low cost, instrument free and easy operation...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136790/paper-based-amperometric-sensor-for-determination-of-acetylcholinesterase-using-screen-printed-graphene-electrode
#20
Yosita Panraksa, Weena Siangproh, Thitikan Khampieng, Orawon Chailapakul, Amara Apilux
A simple paper-based sensor with electrochemical detection was first developed for rapid, selective, and sensitive determination of acetylcholinesterase (AChE). The screen-printed graphene electrode was used as working electrode providing sensitivity for the sensor. The amperometric detection of AChE is based on the determination of thiocholine (TCh) produced from hydrolysis of acetylthiocholine chloride (ATCh) by AChE. To detect TCh, the ATCh immobilized sheet was stacked onto the detection sheet using double adhesive tape, then samples of AChE were dropped on the back side of an ATCh immobilized sheet with only 1min of incubation time...
February 1, 2018: Talanta
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