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https://www.readbyqxmd.com/read/29342479/time-spent-on-dedicated-patient-care-and-documentation-tasks-before-and-after-the-introduction-of-a-structured-and-standardized-electronic-health-record
#1
Erik Joukes, Ameen Abu-Hanna, Ronald Cornet, Nicolette F de Keizer
BACKGROUND:  Physicians spend around 35% of their time documenting patient data. They are concerned that adopting a structured and standardized electronic health record (EHR) will lead to more time documenting and less time for patient care, especially during consultations. OBJECTIVE:  This study measures the effect of the introduction of a structured and standardized EHR on documentation time and time for dedicated patient care during outpatient consultations...
January 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29336569/paper-based-dna-reader-for-visualized-quantification-of-soil-transmitted-helminth-infections
#2
Alex Guan Wang, Tianyu Dong, Hayam Mansour, Gabriela Matamoros, Ana L Sanchez, Feng Li
Soil-transmitted helminth (STH) infections are a global health issue affecting nearly one-third of the world's population. As most endemic areas of STH are impoverished countries or regions with limited healthcare resources, the accurate diagnosis of STH requires analytical tools that are not only quantitative, but also portable, inexpensive, and with no or minimal demand for external instrument. Herein, we introduce a novel paper-based diagnostic device, termed quantitative paper-based DNA reader (qPDR), capable of quantifying STH at the molecular level by measuring distance as readout, thus eliminating the need for external readers...
January 16, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29332230/a-cardioid-oscillator-with-asymmetric-time-ratio-for-establishing-cpg-models
#3
Q Fu, D H Wang, L Xu, G Yuan
Nonlinear oscillators are usually utilized by bionic scientists for establishing central pattern generator models for imitating rhythmic motions by bionic scientists. In the natural word, many rhythmic motions possess asymmetric time ratios, which means that the forward and the backward motions of an oscillating process sustain different times within one period. In order to model rhythmic motions with asymmetric time ratios, nonlinear oscillators with asymmetric forward and backward trajectories within one period should be studied...
January 13, 2018: Biological Cybernetics
https://www.readbyqxmd.com/read/29331916/aerobic-exercise-is-more-effective-than-goal-based-exercise-for-the-treatment-of-cognition-in-parkinson-s-disease
#4
Carolina R A Silveira, Eric A Roy, Brittany N Intzandt, Quincy J Almeida
BACKGROUND: Little is known about how different exercise modalities influence cognition in Parkinson's disease (PD). Moreover, the focus of previous investigations on examining the effects of exercise mainly on executive functions and the exclusion of individuals with cognitive impairment may limit the potential to define exercise as a treatment for cognitive decline in PD. OBJECTIVE: The aim of this study was to compare the effects of aerobic and goal-based exercise on five cognitive domains in cognitively normal and impaired individuals with PD...
January 10, 2018: Brain and Cognition
https://www.readbyqxmd.com/read/29331429/paper-based-fluorescent-sensor-via-aggregation-induced-emission-fluorogen-for-facile-and-sensitive-visual-detection-of-hydrogen-peroxide-and-glucose
#5
Jiafu Chang, Haiyin Li, Ting Hou, Wenna Duan, Feng Li
Hydrogen peroxide (H2O2), an important reactive oxygen species (ROS), is related to the oxidative stress in organisms, and plays important roles in a variety of cellular activities as well. So it is of crucial importance to develop sensitive and accurate sensing strategies to detect H2O2 in biological systems. Herein, by taking advantage of the unique emission characteristics of aggregation induced emission (AIE) fluorogens, we proposed a non-enzymatic fluorescence platform for facile and sensitive detection of H2O2, both in solution state using fluorescence spectrometer and on paper-based sensor via visual inspection...
January 6, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29330381/paper-based-inkjet-bioprinting-to-detect-fluorescence-resonance-energy-transfer-for-the-assessment-of-anti-inflammatory-activity
#6
Annie Agnes Suganya Samson, Jungmi Lee, Joon Myong Song
For the first time, a paper-based fluorescence resonance energy transfer (FRET) determination with cyclic AMP (cAMP)-specific phosphodiesterase 4B (PDE4B) inhibitory assay using an inkjet-printing technique is proposed. Non-fabricated parchment paper is found to constitute a unique substrate to measure fluorescent energy transfer, due to its insignificant self-absorption, and enables efficient sample interaction. Here, we report the responsive FRET signals generated on paper, upon sequentially printing reaction components on parchment paper using a conventional inkjet printer equipped with four cartridges...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29327112/simultaneous-pre-concentration-and-separation-on-simple-paper-based-analytical-device-for-protein-analysis
#7
Ji-Cheng Niu, Ting Zhou, Li-Li Niu, Zhen-Sheng Xie, Fang Fang, Fu-Quan Yang, Zhi-Yong Wu
In this work, fast isoelectric focusing (IEF) was successfully implemented on an open paper fluidic channel for simultaneous concentration and separation of proteins from complex matrix. With this simple device, IEF can be finished in 10 min with a resolution of 0.03 pH units and concentration factor of 10, as estimated by color model proteins by smartphone-based colorimetric detection. Fast detection of albumin from human serum and glycated hemoglobin (HBA1c) from blood cell was demonstrated. In addition, off-line identification of the model proteins from the IEF fractions with matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) was also shown...
January 11, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29323486/a-ph-sensing-optode-for-mapping-spatiotemporal-gradients-in-3d-paper-based-cell-cultures
#8
Rachael M Kenney, Matthew W Boyce, Nathan Whitman, Brenden P Kromhout, Matthew R Lockett
Paper-based cultures are an emerging platform for preparing 3D tissue-like structures. Chemical gradients can be imposed upon these cultures, generating microenvironments similar to those found in poorly vascularized tumors. There is increasing evidence that the tumor microenvironment is responsible for promoting drug resistance and increased invasiveness. Acidosis, or the acidification of the extracellular space, is particularly important in promoting these aggressive cancer phenotypes. To better understand how cells respond to acidosis there is a need for 3D culture platforms that not only model relevant disease states, but also contain sensors capable of quantifying the extracellular environment...
January 11, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29323478/simultaneous-detection-of-antibiotic-resistance-genes-on-paper-based-chip-using-ru-phen-2dppz-2-turn-on-fluorescence-probe
#9
Bofan Li, Xiaoming Zhou, Hongxing Liu, Huaping Deng, Ru Huang, Da Xing
Antibiotic resistance, the ability of some bacteria to resist antibiotic drug, has been a major global health burden due to the extensive use of antibiotic agents. Antibiotic resistance is encoded via respective genes, hence the specific detection of these genes is necessary for diagnostic and treat of antibiotic resistance cases. Conventional methods for monitoring antibiotic resistance genes require sample to be transported to a central laboratory for tedious and sophisticated tests, which is grueling and time-consuming...
January 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29322927/cpredictor3-0-detecting-protein-complexes-from-ppi-networks-with-expression-data-and-functional-annotations
#10
Ying Xu, Jiaogen Zhou, Shuigeng Zhou, Jihong Guan
BACKGROUND: Effectively predicting protein complexes not only helps to understand the structures and functions of proteins and their complexes, but also is useful for diagnosing disease and developing new drugs. Up to now, many methods have been developed to detect complexes by mining dense subgraphs from static protein-protein interaction (PPI) networks, while ignoring the value of other biological information and the dynamic properties of cellular systems. RESULTS: In this paper, based on our previous works CPredictor and CPredictor2...
December 21, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29321466/an-instrument-free-detection-of-antioxidant-activity-using-paper-based-analytical-devices-coated-with-nanoceria
#11
Thirada Piyanan, Anan Athipornchai, Charles S Henry, Yupaporn Sameenoi
This work reports a portable distance-based detection paper device that has a thermometer-like shape for rapid, instrument-free determination of antioxidant activity using a nanoceria assay. The assay is based on partial reduction of cerium ion from Ce4+ to Ce3+ on nanoceria deposited along the detection channel by antioxidants present in food, giving highly reactive oxidation products. Either these products or the parent antioxidant compounds could then bind to the OH-rich ceria nanoparticles and generate charge transfer ceria-antioxidant complexes resulting in a yellow to brown color change...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29321465/determination-of-ascorbic-acid-in-commercial-tablets-using-pencil-drawn-electrochemical-paper-based-analytical-devices
#12
Virgilio X G Oliveira, Anderson A Dias, Leandro L Carvalho, Thiago M G Cardoso, Flavio Colmati, Wendell K T Coltro
This study describes the use of electrochemical paper-based analytical devices (ePADs) drawn with graphite pencil for the determination of ascorbic acid (AA) in commercial tablets. ePADs were fabricated using vegetal paper and graphite pencil. First, the three-electrode electrochemical cell drawn using a graphical software and toner lines were laser printed on the vegetal paper surface to delimit the electrode areas. Then, the electrode regions were manually painted with graphite pencil. Afterwards, the pseudo-reference electrode was defined with the deposition of silver ink over the graphite surface...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29321464/microfluidic-paper-based-analytical-device-for-quantification-of-lead-using-reaction-band-length-for-identification-of-bullet-hole-and-its-potential-for-estimating-firing-distance
#13
Supatana Buking, Phoonthawee Saetear, Warawut Tiyapongpattana, Kanchana Uraisin, Prapin Wilairat, Duangjai Nacapricha, Nuanlaor Ratanawimarnwong
A low-cost and user-friendly microfluidic paper-based analytical device (μPAD) was developed for identification of bullet hole from gunshot residue (GSR) on cotton fabric target. The device (25 × 82 mm) is made of filter paper with a printed pattern consisting of a circular sample loading reservoir (6 mm i.d.), a circular waste reservoir (4 mm i.d.) and a straight flow channel (3 mm wide and 60 mm long). A sticker with a ruler scale in millimeters was mounted alongside the channel. The straight channel is first impregnated with rhodizonate and dried at ambient temperature...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29321463/use-of-a-smartphone-as-a-colorimetric-analyzer-in-paper-based-devices-for-sensitive-and-selective-determination-of-mercury-in-water-samples
#14
Purim Jarujamrus, Rattapol Meelapsom, Somkid Pencharee, Apinya Obma, Maliwan Amatatongchai, Nadh Ditcharoen, Sanoe Chairam, Suparb Tamuang
A smartphone application, called CAnal, was developed as a colorimetric analyzer in paper-based devices for sensitive and selective determination of mercury(II) in water samples. Measurement on the double layer of a microfluidic paper-based analytical device (μPAD) fabricated by alkyl ketene dimer (AKD)-inkjet printing technique with special design doped with unmodified silver nanoparticles (AgNPs) onto the detection zones was performed by monitoring the gray intensity in the blue channel of AgNPs, which disintegrated when exposed to mercury(II) on μPAD...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29321462/microfluidic-paper-based-analytical-device-for-the-determination-of-hexavalent-chromium-by-photolithographic-fabrication-using-a-photomask-printed-with-3d-printer
#15
Hitoshi Asano, Yukihide Shiraishi
This article describes a simple and inexpensive microfluidic paper-based analytical device (μPAD) for the determination of hexavalent chromium (CrVI) in water samples. The μPADs were fabricated on paper by photolithography using a photomask printed with a 3D printer and functionalized with reagents for a colorimetric assay. In the μPAD, CrVI reacts with 1,5-diphenylcarbazide to form a violet-colored complex. Images of μPADs were captured with a digital camera; then the red, green, and blue color intensity of each detection zone were measured using images processing software...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29321461/trends-in-paper-based-electrochemical-biosensors-from-design-to-application
#16
Vivian Bee Chin Lee, Noor Faizah Mohd-Naim, Eiichi Tamiya, Minhaz Uddin Ahmed
Electrochemical bio-sensing using paper-based detection systems is the main focus of this review. The different existing designs of 2-dimensional and 3-dimensional sensors, and fabrication techniques are discussed. This review highlights the effect of adopting different sensor designs, distinct fabrication techniques, as well as different modification methods, in order to produce reliable and reproducible reading. The use of various nanomaterials have been demonstrated in order to modify the surface of electrodes during fabrication to further enhance the signal for subsequent analysis...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29321460/highly-sensitive-paper-based-analytical-devices-with-the-introduction-of-a-large-volume-sample-via-continuous-flow
#17
Yuhi Shimada, Takashi Kaneta
The implementation of continuous flow in paper-based analytical devices (PADs) was challenging because of the large-volume introduction that was created; but this allowed for the development of novel types of PADs for preconcentration, separation, and sensitive detection. In this study, pump-free continuous flow was applied to a distance-based PAD for the determination of iron ions. Continuous flow enabled the introduction of a volume that exceeded what was necessary to fill the hydrophilic channel of a PAD...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29321459/practical-high-performance-lateral-flow-assay-based-on-autonomous-microfluidic-replacement-on-a-film
#18
Yusuke Fuchiwaki, Kenji Goya, Masato Tanaka
Although paper-based microfluidic devices are an ideal platform for point-of-care (POC) diagnostics, it is difficult to achieve microfluidic control required for sensitive analyses such as ELISA on a paper substrate. Here, we present a novel lateral-flow test chip that can perform operations similar to a pump, such as flowing, stopping, and replacing a solution, just by adding the solution onto an inlet port. The chip was fabricated by laminating paper, film, and adhesive tape. For sensitive and accurate detection in an immunoassay, the transparency and flatness of the substrate is crucial for precise analysis of weak light generated by a specific antigen-antibody reaction; however, paper is not flat and is opaque...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29321458/wax-assisted-one-step-enzyme-linked-immunosorbent-assay-on-lateral-flow-test-devices
#19
Masanori Ishii, Pattarachaya Preechakasedkit, Kentaro Yamada, Orawon Chailapakul, Koji Suzuki, Daniel Citterio
Lateral flow tests (LFTs) are widely used analytical tools characterized by portability, operator simplicity and short analysis times. A remaining challenge is their limited analytical sensitivity, which in classical immunoassay formats is overcome by enzyme-linked immunosorbent assay (ELISA) formats. The implementation of ELISA to an LFT format however, is hampered by the complexity of the procedure requiring the enzyme substrate addition after sample addition. In this work, a simple method for automation of this procedure without user interference is presented...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29321457/-paper-based-analytical-devices
#20
(no author information available yet)
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2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
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