keyword
MENU ▼
Read by QxMD icon Read
search

er pr her

keyword
https://www.readbyqxmd.com/read/27853516/pattern-of-triple-negative-epithelial-ovarian-cancer-in-indigenous-african-women
#1
Mustapha Akanji Ajani, Ayodeji Akeem Salami, Olutosin Alaba Awolude, Abideen Olayiwola Oluwasola
Background: Triple negative epithelial ovarian cancer (TNEOC)  refers to ovarian carcinomas that do not express estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor- type 2 (HER-2/neu).  The aim of this study is to determine the pattern of triple negative epithelial ovarian cancer in indigenous African women. Methods: We performed a retrospective review of ER, PR and HER-2/neu expression in 90 Nigerian patients with histologically diagnosed epithelial ovarian cancer...
2016: F1000Research
https://www.readbyqxmd.com/read/27835573/the-associations-between-mast-cell-infiltration-clinical-features-and-molecular-types-of-invasive-breast-cancer
#2
Jianfeng Sang, Dandan Yi, Xiaoqiao Tang, Yifen Zhang, Tao Huang
Associations between mast cell infiltration and the clinical features and known molecular profile of breast cancer remain unclear. The distribution difference of mast cell was evaluated, in 219 patients with no special type of invasive carcinoma, using sorts of age, max diameter of cancer, histological type, lymph node metastasis as well as the expressions of estrogen receptor (ER), progestogen receptor (PR), human epidermal growth factor receptor 2 (HER-2) and nuclear protein Ki67. The mast cell density (MCD) in patients younger than 50 years old was significantly higher than that in patients with age ≥ 50...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27807508/occurrence-of-lymphoma-in-non-gonadal-organ-during-pregnancy-a-report-on-four-cases-and-literature-review
#3
Da-Lin Gao, Qian-Qian Fu, Tian-Tian Zhang, Lin Sun, Yi Pan, Qiong-Li Zhai
Lymphoma rarely occurs during pregnancy, making this condition difficult to define. Lymphomas that occur in reproductive organs during pregnancy exhibit unique clinical characteristics. Among the limited cases, non-Hodgkin's lymphoma (NHL) shows a considerably higher incidence rate than Hodgkin's lymphoma (HL); NHL also displays clinical characteristics, such as high aggressiveness, advanced stage, and poor outcome. This study reports on four cases of lymphomas in non-gonadal organs (HL, n=2; NHL, n=2) during pregnancy...
September 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27768589/nucleotide-excision-repair-pathway-gene-polymorphisms-are-linked-to-breast-cancer-risk-in-a-chinese-population
#4
Bang-Shun He, Tao Xu, Yu-Qin Pan, Han-Jin Wang, William C Cho, Kang Lin, Hui-Ling Sun, Tian-Yi Gao, Shu-Kui Wang
Polymorphisms in nucleotide excision repair (NER) pathway genes are associated with the risk of breast cancer, but the relevance of these associations appeared to vary according to the ethnicity of the subjects. To systemically evaluate the potential associations between NER polymorphisms and breast cancer risk in a Chinese population, we carried out a case-control study on 450 breast cancer patients and 430 healthy controls. Sequenom MassARRAY was used for genotyping, and immunohistochemistry was performed to detect estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) expression in tumor tissue...
October 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27748278/evaluation-of-her2-neu-oncoprotein-in-serum-tissue-samples-of-women-with-breast-cancer
#5
Shailaja Shukla, Bhawana Komal Singh, Om Prakash Pathania, Manjula Jain
BACKGROUND & OBJECTIVES: The proto-oncogene HER2/neu has been extensively studied in breast cancer patients. Serum levels of HER2/neu by ELISA in breast cancer patients were compared with tissue HER2/neu expression and with other clinicopathological parameters with the aim to investigate whether the serum assay could replace the established tests (IHC/FISH) for HER-2 status. METHODS: Blood and Tru-cut biopsy samples were collected for determining HER2/neu status in 64 breast cancer patients...
May 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27743431/breast-cancer-survival-analysis-based-on-immunohistochemistry-subtypes-er-pr-her2-a-retrospective-cohort-study
#6
Jalal Poorolajal, Nahid Nafissi, Mohammad Esmaeil Akbari, Hossein Mahjub, Nader Esmailnasab, Ebrahim Babaee
BACKGROUND: We conducted this study to estimate the prevalence of biomarkers, including estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) among patients with breast cancer and to explore their effects on disease mortality. METHODS: We conducted this registry-based retrospective cohort study in Tehran, in 2014, using the data on 1622 patients with breast cancer, diagnosed pathologically and registered with the Comprehensive Cancer Control Center from 1998 to 2013...
October 2016: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/27729970/improving-systemic-breast-cancer-therapy-time-to-look-beyond-the-primary-tumour
#7
E Vandendriessche, G Van De Putte, R Van Den Broecke, Etm De Jonge
AIM: Intra and inter tumour heterogeneity is a known feature in cancer because tumour cells undergo changes at genetic and epigenetic level as they spread from their primary tumour site. Adjuvant treatment protocols in breast cancer are currently based on the biological characteristics of the primary tumour, which in most cases has been removed surgically. Considering tumour heterogeneity in metastases we examined the present status of knowledge regarding measurable differences in tumour profiling between the primary breast tumour and its synchronous axillary lymph node metastases (ALNM) and if so whether adjuvant therapy directed towards the tumour characteristics of the ALNM instead of those of the primary tumour is more effective...
December 28, 2015: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/27647972/a-case-control-study-about-the-association-between-vascular-endothelial-growth-inhibitor-gene-polymorphisms-and-breast-cancer-risk-in-female-patients-in-northeast-china
#8
Shaoli Han, Lei Liu, Fengyan Xu, Shuang Chen, Weiguang Yuan, Zhenkun Fu, Dalin Li, Dianjun Li
OBJECTIVE: The inhibition of the neovascularization in tumors is a potential therapeutic target of cancer. Vascular endothelial growth inhibitor (VEGI) is a member of the TNF superfamily which has the ability to suppress the formation of new vessels in tumors. In order to study the association between VEGI gene polymorphisms and breast cancer risk, a case-control study was conducted in Chinese Han women in Northeast China. METHODS: Our study involved 708 female breast cancer patients and 685 healthy volunteers...
August 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27645144/prognostic-value-of-primary-tumor-suvmax-on-f-18-fdg-pet-ct-compared-with-semi-quantitative-tumor-uptake-on-tc-99m-sestamibi-breast-specific-gamma-imaging-in-invasive-ductal-breast-cancer
#9
Jang Yoo, Hai-Jeon Yoon, Bom Sahn Kim
OBJECTIVE: This study aimed to evaluate the prognostic value of F-18 FDG PET/CT in comparison with Tc-99m sestamibi breast-specific gamma imaging (BSGI) and previously established clinical prognostic parameters of invasive ductal breast carcinoma (IDC). METHODS: We retrospectively included 157 female IDC patients (mean age 49.2 years, range 29.9-78.9) who underwent PET/CT and BSGI. The maximum standardized uptake value (SUVmax) and tumor to normal background ratios (TNRs) of their primary tumors were measured on PET/CT and BSGI, respectively...
September 19, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27644638/survival-of-triple-negative-versus-triple-positive-breast-cancers-comparison-and-contrast
#10
Preety Negi, Pamela Alice Kingsley, Kunal Jain, Jaineet Sachdeva, Himanshu Srivastava, Sudeep Marcus, Aman Pannu
BACKGROUND: Triple negative (TN) and triple positive (TP) breast cancers both are aggressive types but TN generally has a shorter survival. OBJECTIVES: To compare the clinical characteristics and treatment outcomes for patients with TN versus TP breast cancer and to assess various prognostic factors affecting overall survival. MATERIALS AND METHODS: A retrospective audit of 85 breast cancer patients was conducted in the Department of Radiation Oncology and Medical Oncology on patients from 2006 to 2013 for whom IHC for ER, PgR and Her-2 neu were available...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27591153/prediction-of-nonsentinel-lymph-node-metastasis-in-breast-cancer-patients-with-one-or-two-positive-sentinel-lymph-nodes
#11
Bahadır Öz, Alper Akcan, Serap Doğan, Ümmühan Abdulrezzak, Dicle Aslan, Erdoğan Sözüer, Ertan Emek, Muhammet Akyüz, Ferhan Elmalı, Engin Ok
OBJECTIVE: The aim of the present study was to investigate the association between non sentinel lymph node metastasis (NSLNM) and clinicopathological factors, particularly in the case of sentinel lymph node (SLN) metastasis in one or two, in clinically node negative patients with breast cancer. METHODS: Between 10/2010 and 10/2014, 350 sentinel lymph node biopsy (SLNB) were performed in patients with histologically proven primary breast cancer in our clinic. The data collection includes the following characteristics: age, pathological tumor size, histological type, histological grade, lymphovascular invasion (LVI), number of positive SLN, size of the SLN metastasis (macrometastasis, micrometastasis, isolated tumor cells), multifocality (MF), extracapsuler invasion (ECI) of the SLN, the estrogen receptor (ER) status, the progesterone receptor (PR) status and the Her 2 receptor status, Ki 67 reseptor status...
August 30, 2016: Asian Journal of Surgery
https://www.readbyqxmd.com/read/27562388/circulating-tumor-cells-in-breast-cancer-correlation-with-clinicopathological-parameters-hormone-profile-and-microrna-polymorphisms
#12
Cherry Bansal, Mukta Pujani, Sanjeev Misra, A N Srivastava, U S Singh
OBJECTIVE: Circulating tumor cells are isolated tumor cells in the peripheral blood that serve as important prognostic indicators for many kind of tumors. The study was conducted to know the rate of detection of circulating tumor cells among breast cancer patients in comparison with benign breast diseases and control subjects and to know the association between CTC positivity and various clinicopathological parameters, hormonal profile and microRNA polymorphisms. MATERIAL AND METHOD: In the present case control study, we included 182 healthy controls, 108 cases of benign breast disease and 114 breast carcinoma cases...
2016: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27560716/fucosylation-of-lamp-1-and-lamp-2-by-fut1-correlates-with-lysosomal-positioning-and-autophagic-flux-of-breast-cancer-cells
#13
Keng-Poo Tan, Ming-Yi Ho, Huan-Chieh Cho, John Yu, Jung-Tung Hung, Alice Lin-Tsing Yu
Alpha1,2-fucosyltransferases, FUT1 and FUT2, which transfer fucoses onto the terminal galactose of N-acetyl-lactosamine via α1,2-linkage have been shown to be highly expressed in various types of cancers. A few studies have shown the involvement of FUT1 substrates in tumor cell proliferation and migration. Lysosome-associated membrane protein 1, LAMP-1, has been reported to carry alpha1,2-fucosylated Lewis Y (LeY) antigens in breast cancer cells, however, the biological functions of LeY on LAMP-1 remain largely unknown...
August 25, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27542224/adamts6-suppresses-tumor-progression-via-the-erk-signaling-pathway-and-serves-as-a-prognostic-marker-in-human-breast-cancer
#14
Yuxin Xie, Qiheng Gou, Keqi Xie, Zhu Wang, Yanping Wang, Hong Zheng
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family is involved in tumor development. However, how ADAMTS6 influences cancer remains unknown. We investigated the biological function and clinical implications of ADAMTs6 in breast cancer (BC). Its functional significance in BC cell lines was confirmed by ADAMTs6 overexpression or downregulation both in vitro and in vivo studies. Enhanced ADAMTS6 expression suppressed cell migration, invasion, and tumorigenesis, whereas knockdown promoted these characteristics...
August 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27540429/the-relationship-between-estrogen-receptor-progesterone-receptor-and-human-epidermal-growth-factor-receptor-2-expression-of-breast-cancer-and-the-retention-index-in-dual-phase-18-f-fdg-pet-ct
#15
Hansol Moon, Woo Chul Noh, Hyun-Ah Kim, Eun-Kyu Kim, Ko Woon Park, Seung Sook Lee, Joon Ho Choi, Kyung Woo Han, Byung Hyun Byun, Ilhan Lim, Byung Il Kim, Chang Woon Choi, Sang Moo Lim
PURPOSE: This study investigates the correlation of retention index (RI) using the dual phase FDG PET/CT scan with the breast cancer biomarkers. METHODS: A total of 55 patients with breast cancer underwent dual phase FDG PET/CT scans (60 and 120 min after FDG injection) before treatment. SUVmax and SUVmean of the primary breast tumors were measured, then the percent change of SUVmax and SUVmean between the two scans were calculated, and denoted as RImax and RImean, respectively...
September 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27539136/challenges-of-treating-incidental-synchronous-bilateral-breast-cancer-with-differing-tumour-biology
#16
Jonathan Walter Esclovon, Melissa Ponder, Nail Aydin, Subhasis Misra
A 59-year-old woman with right breast mass was diagnosed with invasive ductal carcinoma (IDC). Workup consisted of bilateral diagnostic mammogram and ultrasound (US); both showed a right breast mass with normal left breast. Core biopsy showed IDC with estrogen receptor negative (ER-)/progesterone receptor negative (PR-) and HER2/neu positive receptor status. The patient underwent carboplatin-based chemotherapy with Herceptin. The mass completely resolved. The patient desired to proceed with bilateral total mastectomy with right sentinel lymph node biopsy (SLNB)...
August 18, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27510014/correlation-of-preoperative-ki67-and-serum-ca15-3-levels-with-outcome-in-early-breast-cancers-a-multi-institutional-study
#17
A Rasmy, W Abozeed, S Elsamany, M El Baiomy, A Nashwa, A Amrallah, E Hasaan, A Alzahrani, M Faris, K Alsaleh, A AlFaraj
BACKGROUND: To investigate the association between preoperative pathological Ki67 labeling index and serum tumor marker cancer antigen 153 (CA 153) with clinicpathological parameters and treatment outcomes in early breast cancer. MATERIALS AND METHODS: A retrospective study at 4 cancer centers in Saudi Arabia and Egypt was performed. Data were collected for female patients diagnosed with unilateral early breast cancer between March 2010 and October 2013. Cases treated with neoadjuvant chemotherapy (NACT) followed by surgery and radiotherapy were included...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27509976/correlation-of-hormone-receptor-and-her2-neu-expression-with-clinicopathologic-parameters-in-primary-breast-tumors
#18
Fouzia Shaikh, Qamar Jamal, Saeeda Baig, Naila Irum Hadi, Noman Majeed
BACKGROUND: Breast cancer (BC) is a major health issue worldwide as well as in Pakistan. All women belonging to any race, ethnicity or lineage are in danger of developing breast cancer. Significant factors influencing the development of breast malignancies are the genetic background, environmental conditions, reproductive parameters, the consequences of female hormones both intrinsic and extrinsic, alteration of immune status, and biologic determinants. MATERIALS AND METHODS: Overall 150 biopsy proven patients were included in the study...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27478808/mutation-screening-of-brca-genes-in-10-iranian-males-with-breast-cancer
#19
Atieh Zorrieh Zahra, Sepideh Kadkhoda, Farkhondeh Behjati, Fatemeh Aghakhani Moghaddam, Azadeh Badiei, Fereidoon Sirati, Hossein Afshin Alavi, Morteza Atri, Ramesh Omranipour, Elahe Keyhani
Male breast cancer is a rare disease with an increasing trend. Due to limited information especially about the genetic basis of the disease in Iran and the lower age of its onset, the disease requires more attention. The aim of this study was to screen the male patients with breast cancer for BRCA mutations as well as tissue markers of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor (HER-2) and cytokeratin 5/6 (CK5/6). Ten Iranian males with breast cancer were selected regardless of their histologic subtypes, age and family history from patients referred to Mehrad, Day and Parsian hospitals in Tehran, Iran, during a two-year period...
2016: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/27436928/impact-of-cyclooxygenase-2-over-expression-on-the-prognosis-of-breast-cancer-patients
#20
Sertaç Ata Güler, Mustafa Ümit Uğurlu, Handan Kaya, Semiha Şen, Yasemin Nazlı, Bahadır M Güllüoğlu
OBJECTIVE: The aim of this present study was to assess the impact of COX-2 over-expression on breast cancer survival. MATERIAL AND METHODS: Non-metastatic invasive breast cancer patients who received adequate loco-regional and systemic treatments were evaluated. Patients' demographic, clinical, pathologic, and treatment-related and survival data were retrieved from their hospital files. COX-2, estrogen/progesterone receptor (ER/PR), HER-2/neu expression and Ki67 index of the tumors were determined immunohistochemically...
2016: Ulusal Cerrahi Dergisi
keyword
keyword
96938
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"