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https://www.readbyqxmd.com/read/29719409/prediction-of-tumor-mutation-burden-in-breast-cancer-based-on-the-expression-of-er-pr-her-2-and-ki-67
#1
Junnan Xu, Xiangyu Guo, Mingxi Jing, Tao Sun
Objective: Cancer immunoediting is the process of eliminating highly immunogenic tumor cells by somatic evolution and protecting the host from tumor development in the host immune system. Frequencies of somatic mutations or tumor mutation burden (TMB) were associated with immunogenicity of breast cancer. This study aimed to predict the level of TMB in patients with breast cancer by the expression of estrogen (ER), progesterone (PR), HER-2, and Ki-67, thereby anticipating the prognosis of patients and the possible response to immunotherapy...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29713164/global-trends-in-nanomedicine-research-on-triple-negative-breast-cancer-a-bibliometric-analysis
#2
REVIEW
Ramon Handerson Gomes Teles, Herick Fernando Moralles, Márcia Regina Cominetti
Nanotechnology has emerged as a promising tool in the clinic to combat several difficult-to-manage diseases, such as cancer, which is the second leading cause of death worldwide. Chemotherapeutic drugs present several limitations such as undesired side effects, low specificity, resistance, and high relapse rates. Triple negative breast cancer (TNBC) is caused by cells that lack specific receptors in their membrane, such as estrogen (ER+) and progesterone (PR+) receptors, or by cells that do not express the amplification of human epidermal growth factor receptor-2 (HER-2+)...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29694313/paget-s-disease-of-the-male-breast-case-report-and-a-point-of-view-from-actual-literature
#3
M Vergine, A Musella, E Gulotta, F Frusone, Alberto De Luca, F Maceli, A Libia, P Benedetti Panici, M Monti
INTRODUCTION: Paget disease of the nipple in man is a very rare breast cancer, and there are not standard procedures or guidelines. In any cases, a Paget's disease could hide an invasive ductal breast cancer. CASE DESCRIPTION: We report the case of a 77-years old man affected by Alzheimer's disease, who presented to our attention because of an ulcerated palpable mass in the right nipple. A biopsy of the lesion showed "intra-epidermic proliferation of epitelioid cells, associated with linfo-plasmacellular infiltration of superficial dermis, compatible with Paget's disease (pTis)"...
March 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29690864/radiogenic-angiosarcoma-of-the-breast-case-report-and-systematic-review-of-the-literature
#4
Askin Dogan, Peter Kern, Beate Schultheis, Günther Häusler, Günther A Rezniczek, Clemens B Tempfer
BACKGROUND: Radiogenic angiosarcoma of the breast (RASB) is a rare late sequela of local irradiation of the breast or chest wall after breast cancer. The prognosis of women with RASB is poor and there is no standardized therapy for this type of malignancy. CASE PRESENTATION: We present the case of a 54 year old woman with RASB (poorly differentiated angiosarcoma of the left breast; pT1, pNX, M0, L0, V0) and a history of invasive-ductal cancer of the left breast (pT1b, G2, pN0, ER positive, PR positive, HER-2/neu negative) treated in July 2012 with breast-conserving surgery, adjuvant chemotherapy with 6 cycles of epirubicin and cyclophosphamide, adjuvant irradiation of the left breast with 50 Gray, and adjuvant endocrine therapy with an aromatase inhibitor...
April 24, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29682102/expression-of-pentose-phosphate-pathway-related-proteins-in-breast-cancer
#5
Junjeong Choi, Eun-Sol Kim, Ja Seung Koo
Purpose: The purpose of this study was to assess the expression of pentose phosphate pathway- (PPP-) related proteins and their significance in clinicopathologic factors of breast cancer. Methods: Immunohistochemical staining for PPP-related proteins (glucose-6-phosphate dehydrogenase [G6PDH], 6-phosphogluconolactonase [6PGL], 6-phosphogluconate dehydrogenase [6PGDH], and nuclear factor-erythroid 2-related factor 2 [NRF2]) was performed using tissue microarray (TMA) of 348 breast cancers...
2018: Disease Markers
https://www.readbyqxmd.com/read/29661737/a-rapid-triage-protocol-to-optimize-cold-ischemic-time-for-breast-resection-specimens
#6
Ellen G East, Matthew Gabbeart, Emily Roberts, Lili Zhao, Julie M Jorns
Prolonged time from specimen excision to adequate formalin exposure, or cold ischemic time (CIT), negatively impacts estrogen receptor (ER), progesterone receptor (PR) and HER-2 biomarker studies routinely performed on breast specimens. Current guidelines recommend CIT of ≤1 h. Since formalin penetrates resections slowly, optimal fixation requires incision. We evaluated the efficacy of a rapid triage protocol developed to optimize CIT. We identified 2821 specimens: 650 (23.0%) excisional biopsies (EB), 1051 (37...
March 6, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29620140/diagnostic-and-prognostic-values-of-contrast%C3%A2-enhanced-ultrasound-combined-with-diffusion%C3%A2-weighted-magnetic-resonance-imaging-in-different-subtypes-of-breast-cancer
#7
Gui-Feng Liu, Zong-Qiang Wang, Shu-Hua Zhang, Xue-Feng Li, Lin Liu, Ying-Ying Miao, Shao-Nan Yu
The present study aimed to investigate the diagnostic and prognostic values of contrast‑enhanced ultrasound (CEUS) combined with diffusion‑weighted magnetic resonance imaging (DW‑MRI) in different subtypes of breast cancer (BC). CEUS and DW‑MRI were conducted in 232 patients with BC prior to surgical treatment. Patients were categorized as having the luminal A subtype, the luminal B subtype, triple‑negative subtype or the human epidermal growth factor receptor 2 (Her‑2)‑positive subtype according to their expression of the estrogen receptor (ER), progesterone receptor (PR) and Her‑2, as detected by immunohistochemistry...
March 27, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29599829/microrna-10b-expression-and-its-correlation-with-molecular-subtypes-of-early-invasive-ductal-carcinoma
#8
Chenming Guo, Minggang Fu, Yilamu Dilimina, Sha Liu, Liying Guo
The present study aimed to determine whether the expression of microRNA (miR)-10b was correlated with the molecular subtypes of early invasive ductal carcinoma of the breast. In situ hybridization was used to detect the expression of miR-10b in 193 patients diagnosed with early invasive ductal carcinoma. Immunohistochemistry was performed to evaluate the expression of estrogen receptor (ER)-α, progesterone receptor (PR) and human epidermal growth factor receptor-2 (Her-2). The positive expression rate of miR-10b in patients with early invasive ductal carcinoma with ER-α (+) or PR (+) was decreased compared with ER-α (-) or PR (-) patients (P<0...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29595317/quantitative-assessment-of-immunohistochemistry-laboratory-performance-by-measuring-analytic-response-curves-and-limits-of-detection
#9
Seshi R Sompuram, Kodela Vani, Anika K Schaedle, Anuradha Balasubramanian, Steven A Bogen
Context Numerous studies highlight interlaboratory performance variability in diagnostic immunohistochemistry (IHC) testing. Despite substantial improvements over the years, the inability to quantitatively and objectively assess immunostain sensitivity complicates interlaboratory standardization. Objective To quantitatively and objectively assess the sensitivity of the immunohistochemical stains for human epidermal growth factor receptor type 2 (HER-2), estrogen receptor (ER), and progesterone receptor (PR) across IHC laboratories in a proficiency testing format...
March 29, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29567881/expression-of-breast-cancer-type-1-and-its-relation-with-expression-of-estrogen-receptors-progesterone-receptors-and-human-epidermal-growth-factor-receptor-2-neu-in-breast-carcinoma-on-trucut-biopsy-specimens
#10
Deepti Verma, Kiran Agarwal, Sanjeev Kumar Tudu
Objective: (1) The objective is to study the immunohistochemical expression of Breast cancer type 1 (BRCA1) in breast carcinoma on trucut biopsy specimens and (2) To relate its expression with that of estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER-2)/neu and the clinicopathological parameters. Settings and Design: A cross-sectional hospital-based study was performed in Lady Hardinge Medical College and Shrimati Sucheta Kriplani Hospital, New Delhi, with collaboration of the Departments of Pathology and Surgery from the period of November 2008 to March 2010...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29545938/the-impact-of-surgical-excision-of-the-primary-tumor-in-stage-iv-breast-cancer-on-survival-a-meta-analysis
#11
Shuangshuang Lu, Jiayi Wu, Yan Fang, Wei Wang, Yu Zong, Xiaosong Chen, Ou Huang, Jian-Rong He, Weiguo Chen, Yafen Li, Kunwei Shen, Li Zhu
Introduction: Approximately 5% of primary breast cancer patients present de novo stage IV breast cancer, for whom systematic therapy is the mainstream treatment. The role of surgical excision of the primary tumor has been controversial due to inconsistent results of relevant studies. Recently, with the reports of some relevant preclinical data, retrospective studies and randomized clinical trials, we've got more evidence to reexamine the issue. Based on those above, a literature review and meta-analysis was performed to determine whether surgery of the primary tumor could improve overall survival in the setting of stage IV breast cancer...
February 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29455872/-pd-l1-expression-and-pd-1-pd-l1-inhibitors-in-breast-cancer
#12
REVIEW
Audrey Monneur, Anthony Gonçalves, François Bertucci
The development of immune checkpoints inhibitors represents one of the major recent advances in oncology. Monoclonal antibodies directed against the programmed cell death protein 1 (PD-1) or its ligand (PD-L1) provides durable disease control, particularly in melanoma, lung, kidney, bladder and head and neck cancers. The purpose of this review is to synthesize current data on the expression of PD-L1 in breast cancer and on the preliminary clinical results of PD-1/PD-L1 inhibitors in breast cancer patients...
March 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29435039/characterization-of-mutations-in-brca1-2-and-the-relationship-with-clinic-pathological-features-of-breast-cancer-in-a-hereditarily-high-risk-sample-of-chinese-population
#13
Min Fang, Li Zhu, Hengyu Li, Xizhou Li, Yanmei Wu, Kainan Wu, Jian Lin, Yuan Sheng, Yue Yu
The database of BRCA1/2 mutations in Chinese population remains incomplete at present. Therefore, the present study aimed to report specific harmful BRCA1/2 mutations in the Chinese population and discuss the clinicopathological features in mutation carriers. BRCA1/2 germline mutation tests for 71 patients with breast cancer from a hereditarily high-risk Chinese population were performed using next-generation sequencing for identification of deleterious mutations. Furthermore, the clinicopathological features between BRCA1/2 mutation carriers and non-carriers were compared...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29416785/predictors-of-lymphovascular-invasion-identified-from-pathological-factors-in-chinese-patients-with-breast-cancer
#14
Sandi Shen, Gaofang Xiao, Richang Du, Ningdong Hu, Xu Xia, Haibo Zhou
This study aimed to evaluate correlations between lymphovascular invasion (LVI) and the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2), Ki-67, CK5/6, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), E-cadherin, BCL11A and P53 in invasive breast cancer and to identify predictors of LVI based on these pathological factors. In all, 392 paraffin-embedded tissues from consecutive patients with primary operable invasive breast cancer were included...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29390502/male-occult-breast-cancer-with-axillary-lymph-node-metastasis-as-the-first-manifestation-a-case-report-and-literature-review
#15
REVIEW
Ruixin Xu, Jianbin Li, Yingjie Zhang, Hongbiao Jing, Youzhe Zhu
RATIONALE: Occult breast cancer (OBC) is extremely rare in males with neither symptoms in the breast nor abnormalities upon imaging examination. PATIENT CONCERNS: This current case report presents a young male patient who was diagnosed with male OBC first manifesting as axillary lymph node metastasis. The physical and imaging examination showed no primary lesions in either breasts or in other organs. DIAGNOSES: The pathological results revealed infiltrating ductal carcinoma in the axillary lymph nodes...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29380701/the-expression-of-dopamine-receptors-gene-and-their-potential-role-in-targeting-breast-cancer-cells-with-selective-agonist-and-antagonist-drugs-could-it-be-the-novel-insight-to-therapy
#16
Hossein Bakhtou, Asiie Olfatbakhsh, Abdolkhaegh Deezagi, Ghasem Ahangari
BACKGROUND: Breast cancer is one of the common causes of mortality for women in Iran and other parts of the world. The substantial increasing rate of breast cancer in both developed and developing countries warns the scientists to provide more preventive steps and therapeutic measures. This study is conducted to investigate the impact of neurotransmitters (e.g., Dopamine) through their receptors and the importance of cancers via damaging immune system. It also evaluates dopamine receptors gene expression in the women with breast cancer at stages II or III and dopamine receptor D2 (DRD2) related agonist and antagonist drug effects on human breast cancer cells, including MCF-7 and SKBR-3...
January 29, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29365416/-mri-findings-and-pathological-features-of-occult-breast-cancer
#17
J J Zhang, X T Yang, X S Du, J X Zhang, L N Hou, J L Niu
Objective: To investigate the magnetic resonance imaging (MRI) findings and clinicopathological features of primary lesions in patients with occult breast cancer (OBC). Methods: The imaging reports from the Breast Imaging Reporting and Data System in 2013 were retrospectively analyzed to investigate the morphology and the time signal intensity curve (TIC) of breast lesions in patients with OBC. The clinical and pathological characteristics of these patients were also included. Results: A total of 34 patients were enrolled...
January 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29353447/the-combined-pn-stage-and-breast-cancer-subtypes-in-breast-cancer-a-better-discriminator-of-outcome-can-be-used-to-refine-the-8th-ajcc-staging-manual
#18
Zheng-Jun Yang, Yue Yu, Jiang-Rui Chi, Meng Guan, Ying Zhao, Xu-Chen Cao
BACKGROUND: pN stage and breast cancer subtypes (BCS) are both well-recognized prognostic indicators. Our previous work has highlighted that patients even with the same pN stage exhibited a significant survival difference in different BCS. Given this achievement, we hypothesized that a statistical interaction might exist between pN stage and BCS. The aim of this retrospective cohort study was to compare the prognostic value of the combined pN stage and BCS (pNnew stage) with either pN stage or BCS alone, and to determine if this combined new stage could serve as an alternative discriminator of outcome...
January 20, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29333017/correlation-of-hormone-receptor-and-human-epidermal-growth-factor-receptor-2-neu-expression-in-breast-cancer-with-various-clinicopathologic-factors
#19
Cherry Bansal, Aarti Sharma, Mukta Pujani, Meenu Pujani, Kiran Lata Sharma, A N Srivastava, U S Singh
Background: A significant development in the breast carcinoma management is the correlation between the presence of hormone receptors in the tumor and response to hormonal therapy and chemotherapy. Human epidermal growth factor receptor-2/neu (Her-2/neu) overexpression also serves as a very useful parameter to predict response to herceptin. Aim of Study: The study was conducted to correlate immunohistochemical expression of markers such as estrogen receptor (ER), progesterone receptor (PR), and Her-2/neu with various clinicopathologic parameters...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29320752/the-value-of-detection-of-s100a8-and-asah1-in-predicting-the-chemotherapy-response-for-breast-cancer-patients
#20
Yu-Hong Li, Hai-Ting Liu, Jing Xu, Ai-Yan Xing, Jie Zhang, Ya-Wen Wang, Gang Yin, Peng Gao
Chemotherapy plays an important role in the treatment of breast cancer. However, chemoresistance remains the main obstacle for effective treatment, leading to poor prognosis. This study aims to investigate the value of detection of S100A8 and ASAH1 in predicting the chemotherapy response. Miller and Payne grades were used to assess the chemotherapy response in breast cancers. The expression of S100A8 and ASAH1, as well as ER, PR, HER-2 and Ki-67 were assessed by immunohistochemical staining in 120 cases of non-special type invasive ductal carcinoma (IDC-NOS)...
January 7, 2018: Human Pathology
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