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https://www.readbyqxmd.com/read/29344573/development-of-an-external-to-internal-convertible-endoscopic-biliary-drainage-device-a-preliminary-prospective-feasibility-study
#1
Akihiro Mori, Shun Ito, Takayuki Yumura, Hiroki Hachiya, Masashi Sawada, Shintaro Hayashi, Noritsugu Ohashi
Background and study aims:  Endoscopic nasobiliary drainage (ENBD) for a malignant stricture in the bile duct has some advantages over endoscopic biliary stenting (EBS). However, ENBD may cause nasopharyngeal discomfort. We developed an external-to-internal convertible endoscopic biliary drainage (ETI-EBD) device that enables both internal and external drainage to occur during a single endoscopy. Patients and methods : This device consists of three parts, comprising a 5-Fr ENBD tube (250 cm) (ENBD-t), an 8...
January 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29343918/pediatric-pelvic-fracture-urethral-distraction-defect-causing-complete-urethrovaginal-avulsion
#2
Ritesh Kumar Singh, Devashish Kaushal, Nikhil Khattar, Rishi Nayyar, T Manasa, Rajeev Sood
Pelvic fracture with urethral injury in girls is an uncommon entity that is usually associated with concomitant vaginal lacerations. Management options vary from immediate exploration and urethral anastomosis to delayed urethroplasty. We report our experience of managing a 10-year old girl presenting 6 months after a pelvic fracture with urethrovaginal injury and a completely obliterated urethral meatus managed successfully with a single-stage bladder tube repair.
January 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29343752/counting-caenorhabditis-elegans-protocol-optimization-and-applications-for-population-growth-and-toxicity-studies-in-liquid-medium
#3
Leona D Scanlan, Steven P Lund, Sanem Hosbas Coskun, Shannon K Hanna, Monique E Johnson, Christopher M Sims, Karina Brignoni, Patricia Lapasset, Elijah J Petersen, John T Elliott, Bryant C Nelson
The nematode Caenorhabditis elegans is used extensively in molecular, toxicological and genetics research. However, standardized methods for counting nematodes in liquid culture do not exist despite the wide use of nematodes and need for accurate measurements. Herein, we provide a simple and affordable counting protocol developed to maximize count accuracy and minimize variability in liquid nematode culture. Sources of variability in the counting process were identified and tested in 14 separate experiments...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343305/relationship-between-eustachian-tube-dysfunction-and-otitis-media-with-effusion-in-radiotherapy-patients
#4
K Akazawa, H Doi, S Ohta, T Terada, M Fujiwara, N Uwa, M Tanooka, M Sakagami
OBJECTIVE: This study evaluated the relationship between radiation and Eustachian tube dysfunction, and examined the radiation dose required to induce otitis media with effusion. METHODS: The function of 36 Eustachian tubes in 18 patients with head and neck cancer were examined sonotubometrically before, during, and 1, 2 and 3 months after, intensity-modulated radiotherapy. Patients with an increase of 5 dB or less in sound pressure level (dB) during swallowing were categorised as being in the dysfunction group...
January 18, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29343026/-applied-research-of-quadri-low-combined-with-automatic-tube-current-modulation-and-iterative-model-reconstruction-technology-in-head-and-neck-ct-angiography
#5
W Cai, C H Hu, X M Wang, S Hu, J Bao, J P Gong, G H Fan, W Zhang, D Shi, M H Qian
Objective: To investigate the feasibility of low tube voltage, low contrast medium concentration, injection rate and volume (quadri-low) combined with automatic tube current modulation (ATCM) and iterative model reconstruction (IMR) technology in head and neck CT angiography (CTA). Methods: A total of 70 patients whose body mass index (BMI)<25 kg/m(2) underwent head and neck CTA and digital subtraction angiography (DSA) from January to July 2017 were enrolled in this prospective study. According to random number table, patients were divided into two groups: group A (n=35) was scanned according to the protocol of 120 kV, 150 mAs, 50 ml and 5 ml/s iopromide (370 mg/ml) and filtered back projection (FBP) reconstruction; group B (n=35) was scanned with 80 kV, ATCM with mean tube current of 100 mAs, 30 ml and 3 ml/s iohexol (300 mg/ml) and IMR; the other parameters kept consistent between the two groups...
January 2, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29338324/effect-of-vertical-or-beveled-chondral-defect-creation-on-rim-deformation-and-contact
#6
Adam B Yanke, Megan L Konopka, Davietta C Butty, Maximilian A Meyer, Eric J Cotter, Alejandro A Espinoza, Brian J Cole
Objective To determine biomechanical effects of knee cartilage defect perimeter morphology based on cartilage strain and opposing subchondral bone contact. Design Articular cartilage defects were created in 5 bovine femoral condyles: group 1, 45° inner bevel with 8-mm rim; group 2, vertical with 8-mm rim; and group 3, 45° outer bevel with 8-mm base. Samples were placed into a custom-machined micro-computed tomography tube and subjected to 800 N of axial loading. DICOM data were used to calculate cartilage thickness 4 and 6 mm from the center, distance between tibial cartilage surface and femoral subchondral bone, and contact width between tibial cartilage and subchondral bone...
January 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29337215/anti-angiogenic-effects-of-qingdu-granule-on-breast-cancer-through-inhibiting-nfat-signaling-pathway
#7
Xin Zhao, Jinyu Liu, Lili Feng, Shasha Ge, Shijun Yang, Chen Chen, Xiaoya Li, Lin Peng, Yuxue Mu, Yueqi Wang, Daozhao Gu, Yi Guo, Geng Lin, Bo Deng, Zhiqiang Cheng, Dayong Cai
ETHNOPHARMACOLOGICAL RELEVANCE: Qingdu granule (QDG), a traditional Chinese herbal prescription, had anti-tumor effect on breast cancer. However the underlying mechanism of QDG was unclear. THE AIM OF THIS STUDY: The present study aimed to investigate whether QDG could inhibit angiogenesis of breast cancer via acting on nuclear factor of activated T-cells (NFAT) signaling pathway. This was implicated in human umbilical vein endothelial cells (HUVECs) in vitro and breast cancer xenograft model in vivo...
January 11, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29336751/laparoscopic-exploration-can-salvage-recurrent-common-bile-duct-stone-after-cholecystectomy
#8
Wen-Song Liu, Yan Zou, Bo Yang, Yong Jiang, Dong-Lin Sun
Conventionally, patients suffered from recurrent common bile duct (CBD) stone after cholecystectomy are suggested to be treated with endoscopic retrograde cholangiopancreaticography. This study was designed to explore the feasibility of laparoscopic common bile duct exploration (LCBDE) as a salvage procedure for recurrent CBD calculi after cholecystectomy. A retrospective review was conducted of data from 65 patients who underwent LCBDE for recurrent CBD calculi after cholecystectomy from January 2011 to July 2015...
December 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29336287/endoscopically-assisted-crawford-tube-placement-results-in-shorter-general-anesthesia-times-in-pediatric-patients
#9
Mitchell R Dobberpuhl, Peter J Timoney, Brett T Comer
BACKGROUND: Crawford tube placement is commonly used to achieve patency of nasolacrimal ducts for epiphora secondary to nasolacrimal duct obstruction. The nasal passages of pediatric patients are narrower than adults, and the result is a relatively higher risk of intranasal complications (e.g., synechiae, bleeding) with Crawford tube placement. There is evidence that general anesthesia may negatively affect the neurocognitive function and behavioral development of children, which prompts efforts to decrease operation times for potential health benefits and also potentially to reduce health care costs...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29333040/pharmacological-screening-of-trachyspermum-ammi-for-antihyperlipidemic-activity-in-triton-x-100-induced-hyperlipidemia-rat-model
#10
Uzma Saleem, Saba Riaz, Bashir Ahmad, Mohammad Saleem
Background: Mortality rate is increasing due to cardiovascular problems throughout the world. These cardiac problems are directly associated with dyslipidemia. Aim: The aim of this study was to evaluate the antihyperlipidemic effect of aqueous extract and methanol extract of Trachyspermum ammi at 1 g/kg, 3 g/kg, and 5 g/kg dose levels in rats. Materials and Methods: For this purpose, 45 male albino rats were used and randomly divided into nine equal groups (n = 5)...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29328186/single-crystal-er3-%C3%A2-%C3%A2-yag-fibers-with-tailored-refractive-index-profiles
#11
L Cheng, T Chick, J Chapman, E F C Dreyer, C D Nie, S Bera, J A Harrington, S C Rand
Erbium-doped yttrium aluminum garnet (Er3+:YAG) rods were inserted inside undoped tubes and grown into single-crystal fibers of a diameter of 300 μm using the laser-heated pedestal growth technique. Growth at various rates resulted in radially graded distributions of Er3+ dopant ions, as observed using laser-induced fluorescence imaging. Profiles of the refractive index were measured using cross-sectional reflectometry in a microscope. Dopant distributions and the corresponding index profiles were compared with thermal diffusion theory to determine the inter-diffusion coefficient of Y3+ and Er3+ ions at 2000°C, yielding an estimated value of D=(9...
January 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29325319/-application-of-half-dose-spectral-ct-based-on-the-automatic-spectral-imaging-mode-selection-and-adaptive-statistical-iterative-reconstruction-in-the-ct-examination-of-upper-abdomen-in-obese-patients
#12
H P Zhao, P J Lü, L Y Zhang, W R Li, P Hou, J B Gao
Objective: To investigate the value of combined use of half-dose spectral CT based on the automatic spectral imaging mode selection (GSI Assist) and adaptive statistical iterative reconstruction (ASIR) in the CT examination of upper abdomen in obese patients as compared with conventional CT. Methods: Eight-two obese patients (body mass index≥29 kg/m(2)) were prospectively selected from October to December 2016, and contrast-enhanced CT during arterial phase (AP) and portal venous phase (PVP) were carried out in those patients...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29322789/rna-interference-mediated-silencing-of-aquaporin-aqp-5-hinders-angiogenesis-of-colorectal-tumor-by-suppressing-the-production-of-vascular-endothelial-growth-factor
#13
W Wang, Q Li, T Yang, D Li, F Ding, H Sun, G Bai
Aquaporin (AQP)-5 is an essential member of AQP family involved in the tumorigenesis of various malignant tumors. However, its role in the angiogenesis of colorectal cancer is unclear and requires further investigation. In this study, a pRNA-H1.1 vector containing the short hairpin RNA (shRNA) targeting AQP5 mRNA was constructed to inhibit the endogenous expression of AQP5 in human umbilical vein endothelial cells (HUVECs). We found that the AQP5-silenced HUVECs acquired decreased proliferation, migration and tube formation ability...
2018: Neoplasma
https://www.readbyqxmd.com/read/29321075/a-phase-i-open-label-trial-on-the-safety-and-immunogenicity-of-the-adjuvanted-tuberculosis-subunit-vaccine-h1-ic31%C3%A2-in-people-living-in-a-tb-endemic-area
#14
Jemal Hussein, Martha Zewdie, Lawrence Yamuah, Ahmed Bedru, Markos Abebe, Alemnew F Dagnew, Menberework Chanyalew, Asfawesen G Yohannes, Jemal Ahmed, Howard Engers, T Mark Doherty, Peter Bang, Ingrid Kromann, Søren T Hoff, Abraham Aseffa
BACKGROUND: H1/IC31® is a tuberculosis (TB) subunit vaccine candidate consisting of the fusion protein of Ag85B and ESAT-6 (H1) formulated with the IC31® adjuvant. Previous trials have reported on the H1/IC31® vaccine in M. tuberculosis (Mtb)-naïve, BCG-vaccinated and previously Mtb-infected individuals. In this trial, conducted between December 2008 and April 2010, the safety and immunogenicity of H1/IC31® was assessed in participants living in Ethiopia - a highly TB-endemic area...
January 10, 2018: Trials
https://www.readbyqxmd.com/read/29319544/review-of-the-xen-gel-stent-and-innfocus-microshunt
#15
Wesley Green, John T Lind, Arsham Sheybani
PURPOSE OF REVIEW: Two new translimbal glaucoma devices (Xen Gel Stent and InnFocus MicroShunt) have been developed with the goal of optimizing the predictability and safety for subconjunctival glaucoma surgery. RECENT FINDINGS: The new subconjunctival glaucoma implants are manufactured from nonsilicone, biocompatible materials, which may reduce the postoperative inflammatory and fibrotic reactions that can lead to failure. Early data suggests a favorable safety profile with significant reductions in intraocular pressure (IOP)...
January 9, 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29316248/a-standardized-flow-cytometry-procedure-for-the-monitoring-of-regulatory-t-cells-in-clinical-trials
#16
Pitoiset Fabien, Barbié Michèle, Monneret Guillaume, Braudeau Cécile, Pochard Pierre, Pellegrin Isabelle, Trauet Jacques, Labalette Myriam, Klatzmann David, Rosenzwajg Michelle
BACKGROUND: Quantification of regulatory T cells is crucial in immunomonitoring in clinical trials as this cell population has been shown to be involved in a wide range of diseases, including cancers, autoimmune diseases, infections and allergies. Human regulatory T cells are defined as CD4+ CD25+ CD127low FoxP3+ cells, and the standardization of their staining by flow cytometry is a challenge, especially in multicenter clinical trials, notably because of the intracellular location of FoxP3...
January 6, 2018: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29315465/ventilation-strategy-and-anesthesia-management-in-patients-with-severe-tracheal-stenosis-undergoing-urgent-tracheal-stenting
#17
J-H Zhu, M Lei, E-G Chen, Q Qiao, T-D Zhong
BACKGROUND: Stenting of airway stenosis is a common procedure in specialized centers. The aim of this study was to summarize our clinical experience in ventilation strategy and anesthesia management of patients undergoing urgent tracheal stenting. METHODS: Clinical data of 22 patients with severe tracheal stenosis who underwent urgent endoscopic placement of a tracheal stent during a 2-year period were retrospectively reviewed. The efficacy and safety of different ventilation strategies and veno-arterial extracorporeal membrane oxygenation (ECMO), individualized based on the cause and location of tracheal narrowing, were evaluated...
January 7, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29312659/healthcare-associated-infection-and-its-risk-factors-among-patients-admitted-to-a-tertiary-hospital-in-ethiopia-longitudinal-study
#18
Solomon Ali, Melkamu Birhane, Sisay Bekele, Gebre Kibru, Lule Teshager, Yonas Yilma, Yesuf Ahmed, Netsanet Fentahun, Henok Assefa, Mulatu Gashaw, Esayas Kebede Gudina
Background: Healthcare associated infection (HAI) is alarmingly increasing in low income settings. In Ethiopia, the burden of HAI is still not well described. Methods: Longitudinal study was conducted from May to September, 2016. All wards of Jimma University Medical Centre were included. The incidence, prevalence and risk factors of healthcare associated infection were determined. A total of 1015 admitted patients were followed throughout their hospital stay. Biological specimens were collected from all patients suspected to have hospital aquired infection...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29311272/characterization-of-three-sugar-transporters-stp7-stp8-and-stp12
#19
Theresa Maria Rottmann, Franz Klebl, Sabine Schneider, Dominik Kischka, David Rüscher, Norbert Sauer, Ruth Stadler
The controlled distribution of sugars between assimilate exporting source tissues and sugar consuming sink tissues is a key element for plant growth and development. Monosaccharide transporters of the SUGAR TRANSPORT PROTEIN (STP) family contribute to the uptake of sugars into sink cells. Here we report on the characterization of STP7, STP8 and STP12, three previously uncharacterized members of this family in Arabidopsis thaliana. Heterologous expression in yeast (Saccharomyces cerevisiae) revealed that STP8 and STP12 catalyze the high-affinity proton-dependent uptake of glucose and also accept galactose and mannose...
January 8, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29305940/complications-and-outcomes-of-pregnancy-and-cesarean-delivery-in-women-with-neuropathic-bladder-and-lower-urinary-tract-reconstruction
#20
Joshua D Roth, Jessica T Casey, Benjamin M Whittam, Konrad M Szymanski, Martin Kaefer, Richard C Rink, Frank P Schubert, Mark P Cain, Rosalia Misseri
Objective To determine the outcomes of pregnancy and cesarean delivery (CD) delivery in women with neuropathic bladder (NB) and pediatric lower urinary tract reconstruction (LUTR) as these women often have normal fertility and may become pregnant. Methods We reviewed consecutive patients from July 2001 to June 2016 with NB due to spinal dysphraphism who underwent LUTR, became pregnant, and had a CD at our institution. We collected data on demographics, hydronephrosis, symptomatic urinary tract infection (UTI), continence and catheterization during pregnancy...
January 3, 2018: Urology
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