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https://www.readbyqxmd.com/read/28077159/concurrent-chemoradiotherapy-combined-with-enteral-nutrition-support-a-radical-treatment-strategy-for-esophageal-squamous-cell-carcinoma-patients-with-malignant-fistulae
#1
Li Ma, Guang-Yu Luo, Yu-Feng Ren, Bo Qiu, Hong Yang, Chun-Xia Xie, Song-Ran Liu, Shi-Liang Liu, Zhao-Lin Chen, Qun Li, Jian-Hua Fu, Meng-Zhong Liu, Yong-Hong Hu, Wen-Feng Ye, Hui Liu
BACKGROUND: Concurrent chemoradiotherapy (CCRT) significantly increases the survival rate of esophageal squamous cell carcinoma (ESCC) patients with malignant fistulae. Recent clinical evidence has shown the benefits of enteral nutrition for malnourished cancer patients. In this study, we aimed to validate that, with the support of enteral nutrition, ESCC patients who develop malignant fistulae might be able to complete CCRT and achieve long-term survival. METHODS: We reviewed the medical records of 652 patients with ESCC who received definitive CCRT at Sun Yat-sen University Cancer Center between January 2010 and December 2012...
January 11, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28075437/comparison-of-irrigation-times-using-gravity-and-high-pressure-lavage
#2
Stefano Muscatelli, Andrea Howe, Nathan N O'Hara, Robert V O'Toole, Sheila A Sprague, Gerard P Slobogean
The benefits of high-pressure pulsatile lavage for open fracture irrigation have been controversial based on conflicting experimental animal research. Recently published data definitively demonstrated that irrigation pressure does not affect the incidence of reoperation for the treatment of open fractures. However, proponents of pulsatile lavage argue a faster irrigation time is an important benefit of the high-pressure treatment. The purpose of this study was to determine the difference in irrigation time between gravity and high-pressure lavage...
January 11, 2017: Orthopedics
https://www.readbyqxmd.com/read/28074964/how-the-alignment-of-adsorbed-ortho-h-pairs-determines-the-onset-of-selective-carbon-nanotube-etching
#3
U Khalilov, A Bogaerts, B Xu, T Kato, T Kaneko, E C Neyts
Unlocking the enormous technological potential of carbon nanotubes strongly depends on our ability to specifically produce metallic or semiconducting tubes. While selective etching of both has already been demonstrated, the underlying reasons, however, remain elusive as yet. We here present computational and experimental evidence on the operative mechanisms at the atomic scale. We demonstrate that during the adsorption of H atoms and their coalescence, the adsorbed ortho hydrogen pairs on single-walled carbon nanotubes induce higher shear stresses than axial stresses, leading to the elongation of HC-CH bonds as a function of their alignment with the tube chirality vector, which we denote as the γ-angle...
January 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28074928/exocyst-subunit-sec3a-marks-the-germination-site-and-is-essential-for-pollen-germination-in-arabidopsis-thaliana
#4
Yan Li, Xiaoyun Tan, Mengru Wang, Bingxuan Li, Yanxue Zhao, Chengyun Wu, Qingchen Rui, Junxia Wang, Zhongyuan Liu, Yiqun Bao
Arabidopsis exocyst subunit SEC3A has been reported to participate in embryo development. Here we report that SEC3A is involved during pollen germination. A T-DNA insertion in SEC3A leads to an absolute, male-specific transmission defect that can be complemented by the expression of SEC3A coding sequence from the LAT52 promoter or SEC3A genomic DNA. No obvious abnormalities in the microgametogenesis are observed in the sec3a/SEC3A mutant, however, in vitro and in vivo pollen germination are defective. Further studies reveal that the callose, pectin, and cellulose are apparently not deposited at the germination site during pollen germination...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28071058/h-abstraction-by-oh-from-large-branched-alkanes-overall-rate-measurements-and-site-specific-tertiary-rate-calculations
#5
Dapeng Liu, Fethi Khaled, Binod Raj Giri, Emmanuel Assaf, Christa Fittschen, Aamir Farooq
Reaction rate coefficients for the reaction of hydroxyl (OH) radicals with nine large branched alkanes (i.e., 2-methyl-3-ethyl-pentane, 2,3-dimethyl-pentane, 2,2,3-trimethyl-butane, 2,2,3-trimethyl-pentane, 2,3,4-trimethyl-pentane, 3-ethyl-pentane, 2,2,3,4-tetramethyl-pentane, 2,2-dimethyl-3-ethyl-pentane and 2,4-dimethyl-3-ethyl-penatane) are measured at high temperatures (900 - 1300 K) using a shock tube and narrow line-width OH absorption diagnostic in the UV region. In addition, room-temperature measurements of six out of these nine rate coefficients are performed in a photolysis cell using high repetition laser-induced fluorescence (LIF) of OH radicals...
January 10, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28067585/folic-acid-education-for-hispanic-women-the-promotora-de-salud-model
#6
Alina L Flores, Jennifer Isenburg, Christina L Hillard, Leslie deRosset, Lisa Colen, Troy Bush, Cara T Mai
BACKGROUND: Although rates of neural tube defects (NTDs) have declined in the United States since fortification, disparities still exist with Hispanic women having the highest risk of giving birth to a baby with a NTD. The Promotora de Salud model using community lay health workers has been shown to be an effective tool for reaching Hispanics for a variety of health topics; however, literature on its effectiveness in folic acid interventions is limited. MATERIALS AND METHODS: An intervention using the Promotora de Salud model was implemented in four U...
January 9, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28062282/coupling-of-vinculin-to-f-actin-demands-syndecan-4-proteoglycan
#7
R P Cavalheiro, M A Lima, T R Jarrouge-Bouças, G M Viana, C C Lopes, V J Coulson-Thomas, J L Dreyfuss, E A Yates, I L S Tersariol, H B Nader
Syndecans are heparan sulfate proteoglycans characterized as transmembrane receptors that act cooperatively with the cell surface and extracellular matrix proteins. Syn4 knockdown was performed in order to address its role in endothelial cells (EC) behavior. Normal EC and shRNA-Syn4-EC cells were studied comparatively using complementary confocal, super-resolution and non-linear microscopic techniques. Confocal and super-resolution microscopy revealed that Syn4 knockdown alters the level and arrangement of essential proteins for focal adhesion, evidenced by the decoupling of vinculin from F-actin filaments...
January 3, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/28060287/the-measurement-of-unsteady-surface-pressure-using-a-remote-microphone-probe
#8
Yaoyi Guan, Carl R Berntsen, Michael J Bilka, Scott C Morris
Microphones are widely applied to measure pressure fluctuations at the walls of solid bodies immersed in turbulent flows. Turbulent motions with various characteristic length scales can result in pressure fluctuations over a wide frequency range. This property of turbulence requires sensing devices to have sufficient sensitivity over a wide range of frequencies. Furthermore, the small characteristic length scales of turbulent structures require small sensing areas and the ability to place the sensors in very close proximity to each other...
December 3, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28058546/is-chemical-pyloroplasty-necessary-for-minimally-invasive-esophagectomy
#9
Camille L Stewart, Lauren Wilson, Aidan Hamm, Christan Bartsch, Megan Boniface, Ana Gleisner, John D Mitchell, Michael J Weyant, Robert Meguid, Csaba Gajdos, Barish H Edil, Martin McCarter
BACKGROUND: Many centers use botulinum toxin for chemical pyloroplasty in minimally invasive esophagectomies as prophylaxis against delayed gastric emptying. No previous studies have compared botulinum toxin injection with no pyloric intervention for patients treated with a combined laparoscopic and thoracoscopic approach. The authors hypothesized that chemical pyloroplasty does not improve outcomes for these patients. METHODS: The study investigated patients undergoing minimally invasive esophagectomies from September 2009 to June 2015...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28057128/-expression-and-function-of-long-intergenic-non-protein-coding-rna-regulator-of-reprogramming-in-high-grade-ovarian-serous-cancer
#10
H H Jiang, Y H Lou, X Y Wang, Y Han, Z M Cui
Objective: To investigate the expression of long intergenic non-protein coding RNA-regulator of reprogramming (Linc-ROR) in high-grade ovarian serous cancer, and explore the relationship between Linc-ROR expression and biological function of high-grade ovarian serous cancer. Methods: A total of 34 high-grade ovarian serous cancer tissue samples and 19 normal fallopian tube tissue samples were collected between June 2014 and February 2016. Real-time reverse transcription (RT)-PCR was used to detect the Linc-ROR mRNA expression in different samples...
December 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28056236/-cd137-cd137l-signaling-promotes-angiogenesis-in-atherosclerosis-plaque-of-mice-through-activating-nuclear-factor-of-activated-t-cells-c1
#11
J Y Weng, J C Yan, Y Chen, Z Q Wang, C P Wang, C Shao
Objective: To explore whether CD137-CD137L signaling can promote angiogenesis in atherosclerosis plaque via activating nuclear factor of activated T cells c1 (NFATc1). Methods: Apolipoprotein E knock out mice were divided into the following groups: control group (n=5), CD137 activated group(n=5)and CD137 inhibited group (n=5). Immunohistochemistry was performed to detect the expression of CD31 in aortic plaque. Endothelial cells (bEnd.3) were purchased from ATCC and divided into the following groups: control group, IgG isotype control group, CD137 activated group and CD137 inhibited group...
December 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28056092/improvement-and-evaluation-of-loop-mediated-isothermal-amplification-for-rapid-detection-of-toxoplasma-gondii-infection-in-human-blood-samples
#12
Xi-Meng Sun, Yong-Sheng Ji, Xian-Yong Liu, Mei Xiang, Guang He, Li Xie, Jing-Xia Suo, Xun Suo
Loop-mediated isothermal amplification (LAMP), an attractive DNA amplification method, was developed as a valuable tool for the rapid detection of Toxoplasma gondii. In this study, species-specific LAMP primers were designed by targeting the AF146527 sequence, which was a conserved sequence of 200- to 300-fold repetitive 529 bp fragment of T.gondii. LAMP reaction system was optimized so that it could detect the minimal DNA sample such as a single tachyzoite or 10 copies of recombinant plasmid. No cross-reactivity was found when using DNA from other parasites as templates...
2017: PloS One
https://www.readbyqxmd.com/read/28055247/-staging-of-breast-cancer-and-the-advanced-applications-of-digital-mammogram-what-the-physician-needs-to-know
#13
Maha Hussien Helal, Sahar Mahmoud Mansour, Mai Zaglol, Lamia Adel Salaleldin, Omniya Mokhtar Nada, Marwa Anas Haggag
OBJECTIVE: To study the role of advanced applications of digital mammogram whether contrast enhanced spectral mammography (CESM) or digital breast tomosynthesis (DBT) in the "T" staging of histologically proven breast cancer prior management planning. METHODS: This prospective analysis, we evaluated 98 proved malignant breast masses regarding their size, multiplicity and presence of associated clusters of microcalcifications. Evaluation methods included digital mammography, 3-D tomosynthesis and contrast enhanced spectral mammography...
January 5, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28054362/the-6-minute-mastication-test-a-unique-test-to-assess-endurance-of-continuous-chewing-normal-values-reliability-reproducibility-and-usability-in-patients-with-mitochondrial-disease
#14
Lenie van den Engel-Hoek, Simone Knuijt, Marjo van Gerven, Marloes Lagarde, Jan T Groothuis, Imelda J M de Groot, Mirian C H Janssen
In patients with mitochondrial disease, fatigue and muscle problems are the most common complaints. They also experience these complaints during mastication. To measure endurance in continuous mastication in patients with mitochondrial diseases the 6-minute mastication test (6MMT) was developed. This study included the collection of normal data for the 6MMT in a healthy population (children and adults). During 6 minutes of continuous mastication on a chew tube chewing cycles per minute, total amount of chewing cycles and the difference between minute 1 (M1 ) and minute 6 (M2 ) were collected in 271 healthy participants (5 - 80 years old)...
January 5, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28050500/influence-of-hypertension-on-ph-of-saliva-and-flow-rate-in-elder-adults-correlating-with-oral-health-status
#15
Vijayalaxmi Nimma, Harshavardhan Talla, Manasa Poosa, Madhulatha Gopaladas, Deepika Meesala, L Jayanth
INTRODUCTION: One of the most prevalent systemic conditions seen in the elderly individuals is hypertension, but very sparse knowledge regarding the influence of hypertension on oral health in known. AIM: Therefore, this study was carried out to evaluate the relationship between hypertension and salivary pH, flow rate and its effect on oral health status. MATERIALS AND METHODS: The study included 40 elderly individuals above 60 years of age, of which 20 individuals (control group) were normotensive without using any medication and 20 individuals (study group) were hypertensive using anti-hypertensive medication...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28048959/expression-and-localization-of-carbonic-anhydrase-genes-in-the-serpulid-polychaete-hydroides-elegans
#16
Grant Batzel, Brian T Nedved, Michael G Hadfield
The metalloenzyme, carbonic anhydrase (CA), catalyzes the reversible hydration of carbon dioxide into bicarbonate, and is responsible for biomineralization processes in animals. In the Annelida, the marine worms in the family Serpulidae are typified by the construction of calcium carbonate tubes. Hydroides elegans, a common member of warmwater biofouling communities around the world, provides an outstanding model for studies of calcification. To better understand the molecular process of biomineralization in H...
December 2016: Biological Bulletin
https://www.readbyqxmd.com/read/28048755/mo-fg-campus-iep1-03-establishment-of-provincial-diagnostic-reference-levels-in-pediatric-imaging
#17
E Tonkopi, K O'Brien
PURPOSE: To establish provincial diagnostic reference levels (DRLs) in pediatric general radiography and computed tomography (CT) as a tool for the optimization of exposure parameters. METHODS: Patient dose survey was conducted in the only pediatric hospital in the province of Nova Scotia. The DRLs were established as the 75th percentile of patient dose distributions in different age groups. For routine radiography projections the DRLs were determined in terms of entrance surface dose (ESD) calculated from the radiation output measurements and the tube current-exposure time product (mAs) recorded for each examination...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048706/tu-ab-bra-06-best-in-physics-joint-imaging-therapy-an-mri-compatible-externally-and-internally-deformable-lung-motion-phantom-for-multi-modality-igrt
#18
P Sabouri, T Arai, A Sawant
PURPOSE: MRI has become an attractive tool for tumor motion management. Current MR-compatible phantoms are only capable of reproducing translational motion. This study describes the construction and validation of a more realistic, MRI-compatible lung phantom that is deformable internally as well as externally. We demonstrate a radiotherapy application of this phantom by validating the geometric accuracy of the open-source deformable image registration software NiftyReg (UCL, UK). METHODS: The outer shell of a commercially-available dynamic breathing torso phantom was filled with natural latex foam with eleven water tubes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048604/tu-fg-brb-11-design-and-evaluation-of-a-robotic-c-arm-cbct-system-for-image-guided-proton-therapy
#19
C Hua, W Yao, T Kidani, J Farr, K Tomida, S Ozawa, T Nishimura, T Fujusawa, R Shinagawa, T Merchant
PURPOSE: To describe the design and performance of a ceiling-mounted robotic C-arm CBCT system for image-guided proton therapy. METHODS: Uniquely different from traditional C-arm CBCT used in interventional radiology, the imaging system was designed to provide volumetric image guidance for patients treated on a 190-degree proton gantry system and a 6 degree-of-freedom (DOF) robotic patient positioner. The mounting of robotic arms to the ceiling rails, rather than gantry or nozzle, provides the flexibility in imaging locations (isocenter, iso+27cm in X, iso+100cm in Y) in the room and easier upgrade as technology advances...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048572/tu-h-207a-07-comparison-of-performance-of-tube-current-modulation-of-three-commercial-mdct-scanners
#20
T Ohno, F Araki
PURPOSE: To compare performance of tube-current modulation (TCM) of three commercial MDCT scanners (TOSHIBA Aquilion One, SIEMENS SOMATOM Definition AS+, PHILIPS Brilliance iCT) from tube current measurement, image noise measurement, and Monte Carlo (MC) simulation based on time-resolved air kerma measurement. METHODS: CT image acquisitions were performed with and without TCM by means of TCM phantoms with length of 40 cm which consists of three oval phantoms (10×20 cm, 14×28 cm, 18×36 cm) and one cylindrical phantom with diameter of 10 cm...
June 2016: Medical Physics
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