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https://www.readbyqxmd.com/read/27859782/inhibition-of-the-mitochondrial-calcium-uniporter-mcu-rescues-dopaminergic-neurons-in-pink1-zebrafish
#1
Smijin Soman, Marcus Keatinge, Mahsa Moein, Marc DaCosta, Heather Mortiboys, Alexander Skupin, Sreedevi Sugunan, Michal Bazala, Jacek Kuznicki, Oliver Bandmann
Mutations in PTEN-induced putative kinase 1 (PINK1) are a cause of early onset Parkinson's disease (PD). Loss of PINK1 function causes dysregulation of mitochondrial calcium homeostasis, resulting in mitochondrial dysfunction and neuronal cell death. We report that both genetic and pharmacological inactivation of the mitochondrial calcium uniporter (MCU), located in the inner mitochondrial membrane, prevents dopaminergic neuronal cell loss in pink1(Y431) * mutant zebrafish (Danio rerio) via rescue of mitochondrial respiratory chain function...
November 12, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27818949/the-necrosis-avid-small-molecule-hq4-dtpa-as-a-multimodal-imaging-agent-for-monitoring-radiation-therapy-induced-tumor-cell-death
#2
Marieke A Stammes, Azusa Maeda, Jiachuan Bu, Deborah A Scollard, Iris Kulbatski, Philip J Medeiros, Riccardo Sinisi, Elena A Dubikovskaya, Thomas J A Snoeks, Ermond R van Beek, Alan B Chan, Clemens W G M Löwik, Ralph S DaCosta
PURPOSE: Most effective antitumor therapies induce tumor cell death. Non-invasive, rapid and accurate quantitative imaging of cell death is essential for monitoring early response to antitumor therapies. To facilitate this, we previously developed a biocompatible necrosis-avid near-infrared fluorescence (NIRF) imaging probe, HQ4, which was radiolabeled with (111)Indium-chloride ((111)In-Cl3) via the chelate diethylene triamine pentaacetic acid (DTPA), to enable clinical translation. The aim of the present study was to evaluate the application of HQ4-DTPA for monitoring tumor cell death induced by radiation therapy...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27816364/in%C3%A2-vivo-imaging-reveals-significant-tumor-vascular-dysfunction-and-increased-tumor-hypoxia-inducible-factor-1%C3%AE-expression-induced-by-high-single-dose-irradiation-in-a-pancreatic-tumor-model
#3
Azusa Maeda, Yonghong Chen, Jiachuan Bu, Hilda Mujcic, Bradly G Wouters, Ralph S DaCosta
PURPOSE: To investigate the effect of high-dose irradiation on pancreatic tumor vasculature and microenvironment using in vivo imaging techniques. METHODS AND MATERIALS: A BxPC3 pancreatic tumor xenograft was established in a dorsal skinfold window chamber model and a subcutaneous hind leg model. Tumors were irradiated with a single dose of 4, 12, or 24 Gy. The dorsal skinfold window chamber model was used to assess tumor response, vascular function and permeability, platelet and leukocyte adhesion to the vascular endothelium, and tumor hypoxia for up to 14 days after 24-Gy irradiation...
September 14, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27789730/a-severe-penetrating-cardiac-injury-in-the-absence-of-cardiac-tamponade
#4
Tara M Connelly, Walenty Kolcow, Dave Veerasingam, Mark DaCosta
Penetrating cardiac injury is rare and frequently not survivable. Significant haemorrhage resulting in cardiac tamponade commonly ensues. Such cardiac tamponade is a clear clinical, radiological and sonographic indicator of significant underlying injury. In the absence of cardiac tamponade, diagnosis can be more challenging. In this case of a 26-year old sailor stabbed at sea, a significant pericardial effusion and cardiac tamponade did not occur despite an injury transversing the pericardium. Instead, the pericardial haemorrhage drained into the left pleural cavity resulting in a haemothorax...
October 26, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27758881/hybrid-manganese-dioxide-nanoparticles-potentiate-radiation-therapy-by-modulating-tumor-hypoxia
#5
Azhar Z Abbasi, Claudia R Gordijo, Mohammad Ali Amini, Azusa Maeda, Andrew M Rauth, Ralph S DaCosta, Xiao Yu Wu
Hypoxia in the tumor microenvironment (TME) mediates resistance to radiotherapy (RT) and contributes to poor prognosis in patients receiving RT. Here we report the design of clinically suitable formulations of hybrid manganese dioxide (MnO2) nanoparticles (MDNP) using biocompatible materials to re-oxygenate the TME by reacting with endogenous H2O2. MDNP containing hydrophilic terpolymer-protein-MnO2 or hydrophobic polymer-lipid-MnO2 provided different oxygen generation rates in the TME relevant to different clinical settings...
October 6, 2016: Cancer Research
https://www.readbyqxmd.com/read/27713675/pharmacist-led-model-to-reduce-hospital-readmissions-in-medically-complex-children
#6
Alison M DaCosta, Courtney B Sweet, Lisa R Garavaglia, Francis L Casey, Jeffrey D Lancaster
OBJECTIVES: This pilot study investigated the feasibility and effect on health care utilization of medically complex children participating in a pharmacist-led model for care coordination. Quality of life and satisfaction with care were secondarily assessed for each patient. METHODS: Four medically complex children were enrolled and contacted by the pharmacist weekly for 5 consecutive months. Time for each encounter with a patient was collected. Each patient's hospital admissions, days of stay, emergency department visits, and clinic visits were recorded...
July 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/27692420/dental-esthetics-and-oral-health-related-quality-of-life-in-young-adults
#7
Gerald I Isiekwe, Oyinkan O Sofola, Olanrewaju O Onigbogi, Ifeoma L Utomi, Oluwatosin O Sanu, Oluranti O daCosta
INTRODUCTION: Dental esthetics affects how people are perceived by society and how they perceive themselves, and this may also affect their oral health-related quality of life (OHRQoL). The aim of this study was to compare the impacts of self-perceived and normatively assessed dental esthetics on the OHRQoL of a young adult population. METHODS: This was a cross-sectional descriptive study involving 375 undergraduate university students, aged 18 to 30 years old...
October 2016: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/27688159/safety-and-seizure-control-in-patients-with-mesial-temporal-lobe-epilepsy-treated-with-regional-superselective-intra-arterial-injection-of-autologous-bone-marrow-mononuclear-cells
#8
Jaderson C DaCosta, Mirna W Portuguez, Daniel R Marinowic, Lucas P Schilling, Carolina M Torres, Danielle I DaCosta, Maria Júlia M Carrion, Eduardo F Raupp, Denise C Machado, Ricardo B Soder, Silvia L Lardi, Bernardo Garicochea
Temporal lobe epilepsy (TLE) is a highly prevalent syndrome among people with epilepsy, and is usually refractory to drug treatment. Structural and physiological changes, such as hippocampal sclerosis, are often present in TLE patients. The objective of this study is to evaluate the feasibility and safety of intra-arterial infusion of autologous bone marrow mononuclear cells (BMMC) in adults with medically refractory mesial temporal lobe epilepsy (MTLE) and unilateral hippocampal sclerosis (MTLE-HS). We enrolled 20 patients that had been diagnosed with MTLE-HS and refractory to medical treatment...
September 29, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27666978/transplantation-of-bone-marrow-mononuclear-cells-prolongs-survival-delays-disease-onset-and-progression-and-mitigates-neuronal-loss-in-pre-symptomatic-but-not-symptomatic-als-mice
#9
Gianina Teribele Venturin, Samuel Greggio, Gabriele Zanirati, Daniel Rodrigo Marinowic, Iuri Marques de Oliveira, João Antonio Pêgas Henriques, Jaderson Costa DaCosta
Cell-based therapy provides a novel strategy to restore lost neurons or modulate the degenerating microenvironment in amyotrophic lateral sclerosis (ALS). This study verified the therapeutic potential of bone marrow mononuclear cells (BMMCs) in SOD1(G93A) mice. BMMCs were obtained from enhanced green fluorescent protein (EGFP) transgenic C57BL/6 mice ((EGFP)BMMCs) or from SOD1(G93A) transgenic mice ((mSOD1)BMMCs) and given to mice at the pre-symptomatic or late symptomatic stage. Survival, body weight and motor performance data were recorded...
October 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27624995/erratum-genetic-variability-in-a-frozen-batch-of-mcf-7-cells-invisible-in-routine-authentication-affecting-cell-function
#10
Andre Kleensang, Marguerite M Vantangoli, Shelly Odwin-DaCosta, Melvin E Andersen, Kim Boekelheide, Mounir Bouhifd, Albert J Fornace, Heng-Hong Li, Carolina B Livi, Samantha Madnick, Alexandra Maertens, Michael Rosenberg, James D Yager, Liang Zhao, Thomas Hartung
No abstract text is available yet for this article.
2016: Scientific Reports
https://www.readbyqxmd.com/read/27615992/varsedig-an-algorithm-for-morphometric-characters-selection-and-statistical-validation-in-morphological-taxonomy
#11
Cástor Guisande, Richard P Vari, Jürgen Heine, Emilio García-Roselló, Jacinto González-Dacosta, Baltasar J García Perez-Schofield, Luis González-Vilas, Patricia Pelayo-Villamil
We present and discuss VARSEDIG, an algorithm which identifies the morphometric features that significantly discriminate two taxa and validates the morphological distinctness between them via a Monte-Carlo test. VARSEDIG is freely available as a function of the RWizard application PlotsR (http://www.ipez.es/RWizard) and as R package on CRAN. The variables selected by VARSEDIG with the overlap method were very similar to those selected by logistic regression and discriminant analysis, but overcomes some shortcomings of these methods...
2016: Zootaxa
https://www.readbyqxmd.com/read/27602251/can-imaging-put-the-advanced-back-in-advanced-wound-care
#12
Ralph S DaCosta, Kathryn Ottolino-Perry, Jaideep Banerjee
An effective, scientifically validated, diagnostic tool helps clinicians make better, timely, and more objective medical decisions in the care of their patients. Today, the need for such tools is especially urgent in the field of wound care where patient-centric care is the goal, under ever tightening clinical budget constraints. In an era of countless "innovative" treatment options, that is, advanced dressings, negative pressure devices, and various debridement instruments available to the wound care clinical team, one area that has arguably languished in the past decade has been innovation in wound diagnostics...
August 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27556019/malocclusion-and-early-orthodontic-treatment-requirements-in-the-mixed-dentitions-of-a-population-of-nigerian-children
#13
Oluranti Olatokunbo daCosta, Elfleda Angelina Aikins, Gerald Ikenna Isiekwe, Virginia Efunyemi Adediran
INTRODUCTION: The aims of this study were to establish the prevalence of dental features that indicate a need for early intervention and to ascertain the prevalence of different methods of early treatment among a population of Nigerian children in mixed dentition. METHODS: Occlusal relationships were evaluated in 101 children in mixed dentition between the ages of 6 and 12 years who presented at the Orthodontic Unit, Department of Child Dental Health, Lagos University Teaching Hospital over a 2 years period...
July 2016: Journal of Orthodontic Science
https://www.readbyqxmd.com/read/27517330/use-of-the-sf-36v2-health-survey-as-a-screen-for-risk-of-major-depressive-disorder-in-a-us-population-based-sample-and-subgroup-with-chronic-pain
#14
Jill A Bell, Marco daCosta DiBonaventura, Edward A Witt, Rami Ben-Joseph, Bryce B Reeve
STUDY OBJECTIVES: To assess the feasibility of using the SF-36v2 mental health (MH) and mental component summary (MCS) scores for classification of risk for major depressive disorder (MDD), and to determine cut-off scores based on the sensitivity and specificity in a general US representative sample, and a chronic pain subpopulation. METHODS: Data were analyzed from the 2013 US National Health and Wellness Survey (adults 18-y old and above; N=75,000), and among a chronic pain subpopulation (n=6679)...
August 11, 2016: Medical Care
https://www.readbyqxmd.com/read/27500928/femur-window-chamber-model-for-in-vivo-cell-tracking-in-the-murine-bone-marrow
#15
Yonghong Chen, Azusa Maeda, Jiachuan Bu, Ralph DaCosta
Bone marrow is a complex organ that contains various hematopoietic and non-hematopoietic cells. These cells are involved in many biological processes, including hematopoiesis, immune regulation and tumor regulation. Commonly used methods for understanding cellular actions in the bone marrow, such as histology and blood counts, provide static information rather than capturing the dynamic action of multiple cellular components in vivo. To complement the standard methods, a window chamber (WC)-based model was developed to enable serial in vivo imaging of cells and structures in the murine bone marrow...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27456714/genetic-variability-in-a-frozen-batch-of-mcf-7-cells-invisible-in-routine-authentication-affecting-cell-function
#16
Andre Kleensang, Marguerite M Vantangoli, Shelly Odwin-DaCosta, Melvin E Andersen, Kim Boekelheide, Mounir Bouhifd, Albert J Fornace, Heng-Hong Li, Carolina B Livi, Samantha Madnick, Alexandra Maertens, Michael Rosenberg, James D Yager, Liang Zhaog, Thomas Hartung
Common recommendations for cell line authentication, annotation and quality control fall short addressing genetic heterogeneity. Within the Human Toxome Project, we demonstrate that there can be marked cellular and phenotypic heterogeneity in a single batch of the human breast adenocarcinoma cell line MCF-7 obtained directly from a cell bank that are invisible with the usual cell authentication by short tandem repeat (STR) markers. STR profiling just fulfills the purpose of authentication testing, which is to detect significant cross-contamination and cell line misidentification...
July 26, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27357660/borrowed-alleles-and-convergence-in-serpentine-adaptation
#17
Brian J Arnold, Brett Lahner, Jeffrey M DaCosta, Caroline M Weisman, Jesse D Hollister, David E Salt, Kirsten Bomblies, Levi Yant
Serpentine barrens represent extreme hazards for plant colonists. These sites are characterized by high porosity leading to drought, lack of essential mineral nutrients, and phytotoxic levels of metals. Nevertheless, nature forged populations adapted to these challenges. Here, we use a population-based evolutionary genomic approach coupled with elemental profiling to assess how autotetraploid Arabidopsis arenosa adapted to a multichallenge serpentine habitat in the Austrian Alps. We first demonstrate that serpentine-adapted plants exhibit dramatically altered elemental accumulation levels in common conditions, and then resequence 24 autotetraploid individuals from three populations to perform a genome scan...
July 19, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27354829/topiramate-induced-maculopathy-in-igg4-related-disease
#18
Joanna DaCosta, Saad Younis
This report describes a case of reversible topiramate-induced maculopathy in a 32-year-old female patient with IgG4-related disease. The patient presented with decreased vision associated with anterior uveitis and cystoid macula edema, which was unresponsive to oral and topical steroids. Following topiramate cessation, both cystoid macula edema and vision improved. The ocular side effects of topiramate and putative pharmacological mechanisms for topiramate-induced maculopathy in the context of IgG4-related disease are discussed...
2016: Drug, Healthcare and Patient Safety
https://www.readbyqxmd.com/read/27353445/improved-resolution-of-single-channel-dwell-times-reveals-mechanisms-of-binding-priming-and-gating-in-muscle-achr
#19
Nuriya Mukhtasimova, Corrie J B daCosta, Steven M Sine
The acetylcholine receptor (AChR) from vertebrate skeletal muscle initiates voluntary movement, and its kinetics of activation are crucial for maintaining the safety margin for neuromuscular transmission. Furthermore, the kinetic mechanism of the muscle AChR serves as an archetype for understanding activation mechanisms of related receptors from the Cys-loop superfamily. Here we record currents through single muscle AChR channels with improved temporal resolution approaching half an order of magnitude over our previous best...
July 2016: Journal of General Physiology
https://www.readbyqxmd.com/read/27345393/rad18-wrnip1-and-atmin-promote-atm-signalling-in-response-to-replication-stress
#20
N Kanu, T Zhang, R A Burrell, A Chakraborty, J Cronshaw, C DaCosta, E Grönroos, H N Pemberton, E Anderton, L Gonzalez, S Sabbioneda, H D Ulrich, C Swanton, A Behrens
No abstract text is available yet for this article.
July 28, 2016: Oncogene
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