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Lorie Ellis, Stephanie Korrer, Stacey DaCosta Byfield
: 15 Background: Few studies examine HRU of CLL, the most common hematologic malignancy in adults. This study describes HRU by the most common regimens among CLL patients (pts). METHODS: A retrospective study using a large, national U.S. claims database from 1/2007-10/2013 was conducted. Adult CLL pts (≥2 claims for CLL) with ≥1 claim for systemic anticancer therapy (SACT) were identified; first SACT claim date was the index date. Pts had to have a CLL diagnosis ≤3 months (m) prior to the index date and be continuously enrolled (CE) in the health plan for 24m pre- and ≥6m post-index date...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Lorie Ellis, Stephanie Korrer, Stacey DaCosta Byfield
: 17 Background: WM is a rare, indolent B-cell lymphoma with 1000 to 1500 new cases diagnosed annually in the US. The disease is incurable with current therapy. Prior to January 2015 when ibrutinib was approved by the US FDA for WM, there were no therapies approved in this indication. This study describes initial systemic anti-cancer therapy (SACT) and HRU among WM patients (pts). METHODS: A retrospective study using a large, national US claims database from 1/2007-10/2013 was conducted...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Stacey DaCosta Byfield, Timothy Bancroft, Amy J Anderson, Carolina M Reyes, Arliene Ravelo, Sarika Ogale, Matthew J Matasar, May C Chen
: 24 Background: Impact of strategies for evaluating value and quality of cancer care may vary for patients with metastatic tumors, particularly for strategies considering lines of treatment therapy as distinct events. To aid in evaluating the value and quality of care in patients' overall trajectory of disease, this study examined disease progression, mortality, hospice, and treatment patterns in patients (pts) with metastatic breast (mBC), lung (mLC), and colorectal cancers (mCRC). METHODS: Included were commercially insured and Medicare Advantage adults from a large US health plan administrative claims database (2007-2014); pts had ≥ 2 claims for BC, CRC, or LC, and ≥ 2 claims for metastases...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Jonathan M Hyde, Gérald DaCosta, Constantinos Hatzoglou, Hannah Weekes, Bertrand Radiguet, Paul D Styman, Francois Vurpillot, Cristelle Pareige, Auriane Etienne, Giovanni Bonny, Nicolas Castin, Lorenzo Malerba, Philippe Pareige
Irradiation of reactor pressure vessel (RPV) steels causes the formation of nanoscale microstructural features (termed radiation damage), which affect the mechanical properties of the vessel. A key tool for characterizing these nanoscale features is atom probe tomography (APT), due to its high spatial resolution and the ability to identify different chemical species in three dimensions. Microstructural observations using APT can underpin development of a mechanistic understanding of defect formation. However, with atom probe analyses there are currently multiple methods for analyzing the data...
January 30, 2017: Microscopy and Microanalysis
Dong W Chang, Daniel Dacosta, Martin F Shapiro
No abstract text is available yet for this article.
February 1, 2017: JAMA Internal Medicine
Ali Hassan Alhaiti, Alanod Raffa Alotaibi, Linda Katherine Jones, Cliff DaCosta, George Binh Lenon
Objective. To translate the revised Michigan Diabetes Knowledge Test into the Arabic language and examine its psychometric properties. Setting. Of the 139 participants recruited through King Fahad Medical City in Riyadh, Saudi Arabia, 34 agreed to the second-round sample for retesting purposes. Methods. The translation process followed the World Health Organization's guidelines for the translation and adaptation of instruments. All translations were examined for their validity and reliability. Results. The translation process revealed excellent results throughout all stages...
2016: Journal of Diabetes Research
Smijin Soman, Marcus Keatinge, Mahsa Moein, Marc Da Costa, Heather Mortiboys, Alexander Skupin, Sreedevi Sugunan, Michal Bazala, Jacek Kuznicki, Oliver Bandmann
Mutations in PTEN-induced putative kinase 1 (PINK1) are a cause of early onset Parkinson's disease (PD). Loss of PINK1 function causes dysregulation of mitochondrial calcium homeostasis, resulting in mitochondrial dysfunction and neuronal cell death. We report that both genetic and pharmacological inactivation of the mitochondrial calcium uniporter (MCU), located in the inner mitochondrial membrane, prevents dopaminergic neuronal cell loss in pink1(Y431) * mutant zebrafish (Danio rerio) via rescue of mitochondrial respiratory chain function...
November 12, 2016: European Journal of Neuroscience
Marieke A Stammes, Azusa Maeda, Jiachuan Bu, Deborah A Scollard, Iris Kulbatski, Philip J Medeiros, Riccardo Sinisi, Elena A Dubikovskaya, Thomas J A Snoeks, Ermond R van Beek, Alan B Chan, Clemens W G M Löwik, Ralph S DaCosta
PURPOSE: Most effective antitumor therapies induce tumor cell death. Non-invasive, rapid and accurate quantitative imaging of cell death is essential for monitoring early response to antitumor therapies. To facilitate this, we previously developed a biocompatible necrosis-avid near-infrared fluorescence (NIRF) imaging probe, HQ4, which was radiolabeled with (111)Indium-chloride ((111)In-Cl3) via the chelate diethylene triamine pentaacetic acid (DTPA), to enable clinical translation. The aim of the present study was to evaluate the application of HQ4-DTPA for monitoring tumor cell death induced by radiation therapy...
2016: Frontiers in Oncology
Azusa Maeda, Yonghong Chen, Jiachuan Bu, Hilda Mujcic, Bradly G Wouters, Ralph S DaCosta
PURPOSE: To investigate the effect of high-dose irradiation on pancreatic tumor vasculature and microenvironment using in vivo imaging techniques. METHODS AND MATERIALS: A BxPC3 pancreatic tumor xenograft was established in a dorsal skinfold window chamber model and a subcutaneous hind leg model. Tumors were irradiated with a single dose of 4, 12, or 24 Gy. The dorsal skinfold window chamber model was used to assess tumor response, vascular function and permeability, platelet and leukocyte adhesion to the vascular endothelium, and tumor hypoxia for up to 14 days after 24-Gy irradiation...
January 1, 2017: International Journal of Radiation Oncology, Biology, Physics
Tara M Connelly, Walenty Kolcow, Dave Veerasingam, Mark DaCosta
Penetrating cardiac injury is rare and frequently not survivable. Significant haemorrhage resulting in cardiac tamponade commonly ensues. Such cardiac tamponade is a clear clinical, radiological and sonographic indicator of significant underlying injury. In the absence of cardiac tamponade, diagnosis can be more challenging. In this case of a 26-year old sailor stabbed at sea, a significant pericardial effusion and cardiac tamponade did not occur despite an injury transversing the pericardium. Instead, the pericardial haemorrhage drained into the left pleural cavity resulting in a haemothorax...
October 26, 2016: Interactive Cardiovascular and Thoracic Surgery
Azhar Z Abbasi, Claudia R Gordijo, Mohammad Ali Amini, Azusa Maeda, Andrew M Rauth, Ralph S DaCosta, Xiao Yu Wu
Hypoxia in the tumor microenvironment (TME) mediates resistance to radiotherapy and contributes to poor prognosis in patients receiving radiotherapy. Here we report the design of clinically suitable formulations of hybrid manganese dioxide (MnO2) nanoparticles (MDNP) using biocompatible materials to reoxygenate the TME by reacting with endogenous H2O2 MDNP containing hydrophilic terpolymer-protein-MnO2 or hydrophobic polymer-lipid-MnO2 provided different oxygen generation rates in the TME relevant to different clinical settings...
October 6, 2016: Cancer Research
Alison M DaCosta, Courtney B Sweet, Lisa R Garavaglia, Francis L Casey, Jeffrey D Lancaster
OBJECTIVES: This pilot study investigated the feasibility and effect on health care utilization of medically complex children participating in a pharmacist-led model for care coordination. Quality of life and satisfaction with care were secondarily assessed for each patient. METHODS: Four medically complex children were enrolled and contacted by the pharmacist weekly for 5 consecutive months. Time for each encounter with a patient was collected. Each patient's hospital admissions, days of stay, emergency department visits, and clinic visits were recorded...
July 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Gerald I Isiekwe, Oyinkan O Sofola, Olanrewaju O Onigbogi, Ifeoma L Utomi, Oluwatosin O Sanu, Oluranti O daCosta
INTRODUCTION: Dental esthetics affects how people are perceived by society and how they perceive themselves, and this may also affect their oral health-related quality of life (OHRQoL). The aim of this study was to compare the impacts of self-perceived and normatively assessed dental esthetics on the OHRQoL of a young adult population. METHODS: This was a cross-sectional descriptive study involving 375 undergraduate university students, aged 18 to 30 years old...
October 2016: American Journal of Orthodontics and Dentofacial Orthopedics
Jaderson C DaCosta, Mirna W Portuguez, Daniel R Marinowic, Lucas P Schilling, Carolina M Torres, Danielle I DaCosta, Maria Júlia M Carrion, Eduardo F Raupp, Denise C Machado, Ricardo B Soder, Silvia L Lardi, Bernardo Garicochea
Temporal lobe epilepsy (TLE) is a highly prevalent syndrome among people with epilepsy, and is usually refractory to drug treatment. Structural and physiological changes, such as hippocampal sclerosis, are often present in TLE patients. The objective of this study is to evaluate the feasibility and safety of intra-arterial infusion of autologous bone marrow mononuclear cells (BMMC) in adults with medically refractory mesial temporal lobe epilepsy (MTLE) and unilateral hippocampal sclerosis (MTLE-HS). We enrolled 20 patients that had been diagnosed with MTLE-HS and refractory to medical treatment...
September 29, 2016: Journal of Tissue Engineering and Regenerative Medicine
Gianina Teribele Venturin, Samuel Greggio, Gabriele Zanirati, Daniel Rodrigo Marinowic, Iuri Marques de Oliveira, João Antonio Pêgas Henriques, Jaderson Costa DaCosta
Cell-based therapy provides a novel strategy to restore lost neurons or modulate the degenerating microenvironment in amyotrophic lateral sclerosis (ALS). This study verified the therapeutic potential of bone marrow mononuclear cells (BMMCs) in SOD1(G93A) mice. BMMCs were obtained from enhanced green fluorescent protein (EGFP) transgenic C57BL/6 mice ((EGFP)BMMCs) or from SOD1(G93A) transgenic mice ((mSOD1)BMMCs) and given to mice at the pre-symptomatic or late symptomatic stage. Survival, body weight and motor performance data were recorded...
October 28, 2016: Neuroscience Letters
Andre Kleensang, Marguerite M Vantangoli, Shelly Odwin-DaCosta, Melvin E Andersen, Kim Boekelheide, Mounir Bouhifd, Albert J Fornace, Heng-Hong Li, Carolina B Livi, Samantha Madnick, Alexandra Maertens, Michael Rosenberg, James D Yager, Liang Zhao, Thomas Hartung
No abstract text is available yet for this article.
2016: Scientific Reports
Cástor Guisande, Richard P Vari, Jürgen Heine, Emilio García-Roselló, Jacinto González-Dacosta, Baltasar J García Perez-Schofield, Luis González-Vilas, Patricia Pelayo-Villamil
We present and discuss VARSEDIG, an algorithm which identifies the morphometric features that significantly discriminate two taxa and validates the morphological distinctness between them via a Monte-Carlo test. VARSEDIG is freely available as a function of the RWizard application PlotsR ( and as R package on CRAN. The variables selected by VARSEDIG with the overlap method were very similar to those selected by logistic regression and discriminant analysis, but overcomes some shortcomings of these methods...
September 12, 2016: Zootaxa
Ralph S DaCosta, Kathryn Ottolino-Perry, Jaideep Banerjee
An effective, scientifically validated, diagnostic tool helps clinicians make better, timely, and more objective medical decisions in the care of their patients. Today, the need for such tools is especially urgent in the field of wound care where patient-centric care is the goal, under ever tightening clinical budget constraints. In an era of countless "innovative" treatment options, that is, advanced dressings, negative pressure devices, and various debridement instruments available to the wound care clinical team, one area that has arguably languished in the past decade has been innovation in wound diagnostics...
August 1, 2016: Advances in Wound Care
Oluranti Olatokunbo daCosta, Elfleda Angelina Aikins, Gerald Ikenna Isiekwe, Virginia Efunyemi Adediran
INTRODUCTION: The aims of this study were to establish the prevalence of dental features that indicate a need for early intervention and to ascertain the prevalence of different methods of early treatment among a population of Nigerian children in mixed dentition. METHODS: Occlusal relationships were evaluated in 101 children in mixed dentition between the ages of 6 and 12 years who presented at the Orthodontic Unit, Department of Child Dental Health, Lagos University Teaching Hospital over a 2 years period...
July 2016: Journal of Orthodontic Science
Jill A Bell, Marco daCosta DiBonaventura, Edward A Witt, Rami Ben-Joseph, Bryce B Reeve
STUDY OBJECTIVES: To assess the feasibility of using the SF-36v2 mental health (MH) and mental component summary (MCS) scores for classification of risk for major depressive disorder (MDD), and to determine cut-off scores based on the sensitivity and specificity in a general US representative sample, and a chronic pain subpopulation. METHODS: Data were analyzed from the 2013 US National Health and Wellness Survey (adults 18-y old and above; N=75,000), and among a chronic pain subpopulation (n=6679)...
August 19, 2016: Medical Care
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