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https://www.readbyqxmd.com/read/29652544/acute-effects-of-device-guided-slow-breathing-on-sympathetic-nerve-activity-and-baroreflex-sensitivity-in-posttraumatic-stress-disorder
#1
Ida Fonkoue, Paul J Marvar, Seth D Norrholm, Melanie L Kankam, Yunxiao Li, Dana DaCosta, Barbara O Rothbaum, Jeanie Park
Posttraumatic stress disorder (PTSD) patients have elevated sympathetic nervous system (SNS) reactivity and impaired sympathetic and cardiovagal baroreflex sensitivity (BRS). Device-guided slow breathing (DGB) has been shown to lower blood pressure (BP) and sympathetic activity in other patient populations. We hypothesized that DGB acutely lowers BP, heart rate (HR), and improves BRS in PTSD. In 23 prehypertensive veterans with PTSD, we measured continuous BP, EKG, and muscle sympathetic nerve activity (MSNA) at rest, and during 15 minutes of device-guided slow breathing at 5 breaths/min (DGB; n=13) or identical sham device breathing at normal rates of 14 breaths/min (SHAM; n=10)...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29600825/depression-comorbidity-in-epileptic-rats-is-related-to-brain-glucose-hypometabolism-and-hypersynchronicity-in-the-metabolic-network-architecture
#2
Gabriele Zanirati, Pamella Nunes Azevedo, Gianina Teribele Venturin, Samuel Greggio, Allan Marinho Alcará, Eduardo R Zimmer, Paula Kopschina Feltes, Jaderson Costa DaCosta
OBJECTIVE: Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy syndromes in the world. Depression is an important comorbidity of epilepsy, which has been reported in patients with TLE and in different experimental models of epilepsy. However, there is no established consensus on which brain regions are associated with the manifestation of depression in epilepsy. Here, we investigated the alterations in cerebral glucose metabolism and the metabolic network in the pilocarpine-induced rat model of epilepsy and correlated it with depressive behavior during the chronic phase of epilepsy...
March 30, 2018: Epilepsia
https://www.readbyqxmd.com/read/29514998/t-follicular-helper-like-cells-contribute-to-skin-fibrosis
#3
Devon K Taylor, Nanette Mittereder, Ellen Kuta, Tracy Delaney, Timothy Burwell, Karma Dacosta, Weiguang Zhao, Lily I Cheng, Charles Brown, Anmarie Boutrin, Xiang Guo, Wendy I White, Jie Zhu, Huifang Dong, Michael A Bowen, Jia Lin, Changshou Gao, Li Yu, Madhu Ramaswamy, Marie-Claude Gaudreau, Rob Woods, Ronald Herbst, Gianluca Carlesso
Systemic sclerosis (SSc) is a debilitating inflammatory and fibrotic disease that affects the skin and internal organs. Although the pathophysiology of SSc remains poorly characterized, mononuclear cells, mainly macrophages and T cells, have been implicated in inflammation and fibrosis. Inducible costimulator (ICOS), which is expressed on a subset of memory T helper (TH ) and T follicular helper (TFH ) cells, has been shown to be increased in SSc and associated with disease pathology. However, the identity of the relevant ICOS+ T cells and their contribution to inflammation and fibrosis in SSc are still unknown...
March 7, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29510739/measuring-multiple-parameters-of-cd8-tumor-infiltrating-lymphocytes-in-human-cancers-by-image-analysis
#4
Keith E Steele, Tze Heng Tan, René Korn, Karma Dacosta, Charles Brown, Michael Kuziora, Johannes Zimmermann, Brian Laffin, Moritz Widmaier, Lorenz Rognoni, Ruben Cardenes, Katrin Schneider, Anmarie Boutrin, Philip Martin, Jiping Zha, Tobias Wiestler
BACKGROUND: Immuno-oncology and cancer immunotherapies are areas of intense research. The numbers and locations of CD8+ tumor-infiltrating lymphocytes (TILs) are important measures of the immune response to cancer with prognostic, pharmacodynamic, and predictive potential. We describe the development, validation, and application of advanced image analysis methods to characterize multiple immunohistochemistry-derived CD8 parameters in clinical and nonclinical tumor tissues. METHODS: Commercial resection tumors from nine cancer types, and paired screening/on-drug biopsies of non-small-cell lung carcinoma (NSCLC) patients enrolled in a phase 1/2 clinical trial investigating the PD-L1 antibody therapy durvalumab (NCT01693562), were immunostained for CD8...
March 6, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29440741/ecology-and-genomics-of-an-important-crop-wild-relative-as-a-prelude-to-agricultural-innovation
#5
Eric J B von Wettberg, Peter L Chang, Fatma Başdemir, Noelia Carrasquila-Garcia, Lijalem Balcha Korbu, Susan M Moenga, Gashaw Bedada, Alex Greenlon, Ken S Moriuchi, Vasantika Singh, Matilde A Cordeiro, Nina V Noujdina, Kassaye Negash Dinegde, Syed Gul Abbas Shah Sani, Tsegaye Getahun, Lisa Vance, Emily Bergmann, Donna Lindsay, Bullo Erena Mamo, Emily J Warschefsky, Emmanuel Dacosta-Calheiros, Edward Marques, Mustafa Abdullah Yilmaz, Ahmet Cakmak, Janna Rose, Andrew Migneault, Christopher P Krieg, Sevgi Saylak, Hamdi Temel, Maren L Friesen, Eleanor Siler, Zhaslan Akhmetov, Huseyin Ozcelik, Jana Kholova, Canan Can, Pooran Gaur, Mehmet Yildirim, Hari Sharma, Vincent Vadez, Kassahun Tesfaye, Asnake Fikre Woldemedhin, Bunyamin Tar'an, Abdulkadir Aydogan, Bekir Bukun, R Varma Penmetsa, Jens Berger, Abdullah Kahraman, Sergey V Nuzhdin, Douglas R Cook
Domesticated species are impacted in unintended ways during domestication and breeding. Changes in the nature and intensity of selection impart genetic drift, reduce diversity, and increase the frequency of deleterious alleles. Such outcomes constrain our ability to expand the cultivation of crops into environments that differ from those under which domestication occurred. We address this need in chickpea, an important pulse legume, by harnessing the diversity of wild crop relatives. We document an extreme domestication-related genetic bottleneck and decipher the genetic history of wild populations...
February 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29356341/cryopreserved-neonatal-hepatocytes-may-be-a-source-for-transplantation-evaluation-of-functionality-toward-clinical-use
#6
Charlotte A Lee, Anil Dhawan, Valeria Iansante, Sharon Lehec, Shirin E Khorsandi, Celine Filippi, Simon Walker, Raquel Fernandez-Dacosta, Nigel Heaton, Sanjay Bansal, Ragai R Mitry, Emer Fitzpatrick
Neonatal livers are a potential source of good-quality hepatocytes for clinical transplantation. We compared viability and function of neonatal hepatocytes (NHs) and adult hepatocytes (AHs) and report their clinical use both intraportally and in alginate microbeads. Following isolation from donor livers, hepatocyte function was assessed using albumin, alpha-1-antitrypsin, and factor VII. Metabolic function was investigated by measuring resorufin conjugation, ammonia metabolism, uridine diphosphate glucuronosyltransferase enzyme activity, and cytochrome P450 (CYP) function following induction...
March 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29329823/atypical-presentation-of-cmv-pneumonia-in-a-heart-transplant-patient
#7
S Boussouar, L Campedel, P Dacosta Noble, M W Turki, J Calvo, V Pourcher, C Rolland-Debord
No abstract text is available yet for this article.
March 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29200188/the-measurable-benefits-of-a-workplace-wellness-program-in-canada-results-after-one-year
#8
Ilka Lowensteyn, Violette Berberian, Patrick Belisle, Deborah DaCosta, Lawrence Joseph, Steven A Grover
OBJECTIVE: Evaluate the impact of an employee wellness program in Canada. METHODS: A comprehensive program including web-based lifestyle challenges was evaluated with annual health screenings. RESULTS: Among 730 eligible employees, 688 (94%) registered for the program, 571 (78%) completed a health screening at baseline, and 314 (43%) at 1 year. Most (66%) employees tracked their activity for more than 6 weeks. At one year follow-up, there were significant clinical improvements in systolic blood pressure -3...
December 1, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29188745/bariatric-surgery-versus-conservative-management-for-morbidly-obese-patients-in-spain-a-cost-effectiveness-analysis
#9
Raquel Sanchez-Santos, Esther Mariño Padin, Daniel Adam, Oleg Borisenko, Sergio Estevez Fernandez, Ester Carrera Dacosta, Sonia González Fernández, Juan Turnes Vazquez, Juan Carlos Ruiz de Adana, Felipe de la Cruz Vigo
BACKGROUND: We assessed the cost-effectiveness of bariatric surgery (BS) versus conservative management (CM) for treating morbid obesity in Spain. METHODS: We developed a probabilistic Markov model to estimate health outcomes, quality-adjusted life years (QALY), life years gained (LYG), and costs over lifetime and 10-year horizons. Combined common BS procedures were compared with CM. Clinical and utility inputs were obtained from the literature and resource use and costs from local sources (€2017)...
November 30, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29152166/a-retrospective-cohort-study-of-treatment-patterns-among-patients-with-metastatic-soft-tissue-sarcoma-in-the-us
#10
Victor M Villalobos, Stacey DaCosta Byfield, Sameer R Ghate, Oluwakayode Adejoro
Background: Since treatment patterns in metastatic soft tissue sarcoma (mSTS) have not been studied subsequent to US approval of pazopanib in 2012, this study sought to examine mSTS treatment patterns by line of therapy, including regimen and duration of therapy. Methods: This retrospective study employed administrative claims from a large US health plan from 1/2006-9/2015. Adult mSTS patients were required to have an NCCN-recommended therapy and be continuously enrolled in the health plan during the study period...
2017: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29028577/co2-adsorption-at-nitrogen-doped-carbons-prepared-by-k2co3-activation-of-urea-modified-coconut-shell
#11
Limin Yue, Qiongzhang Xia, Liwei Wang, Linlin Wang, Herbert DaCosta, Jie Yang, Xin Hu
This article reports on the synthesis and characterization of porous nitrogen-doped carbons synthesized by carbonization of coconut shell followed by urea modification and K2CO3 activation. The as-synthesized samples were carefully characterized by various techniques. This series of samples demonstrate high CO2 uptake at 1bar, up to 3.71mmol/g at 25°C in addition to 5.12mmol/g at 0°C. Furthermore, these sorbents possess fast CO2 adsorption kinetics, stable reusability, moderate heat of CO2 adsorption, reasonable CO2/N2 selectivity, and high dynamic CO2 capture capacity under simulated flue gas conditions...
September 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28971485/evolution-of-the-serologic-and-virologic-course-of-occult-hbv-infection-in-therapy-experienced-hiv-co-infected-patients
#12
Edina Amponsah-Dacosta, Selokela G Selabe, Maphahlaganye J Mphahlele
We investigated how the natural course of occult hepatitis B virus (HBV) infection (OBI) may evolve during HIV co-infection and long term HBV-active HAART. From a cohort of 181 HIV infected patients who were consecutively recruited over a 5 year period, 28 HBV co-infected patients with sequential sera (n = 98) were identified. Iterative HBV serology and viral loads were determined before and during treatment. The viral HBsAg gene was then serially amplified, directly sequenced, and molecularly characterized...
February 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/28916434/effects-of-icos-t-cell-depletion-via-afucosylated-monoclonal-antibody-medi-570-on-pregnant-cynomolgus-monkeys-and-the-developing-offspring
#13
Simone M Nicholson, Gianluca Carlesso, Lily I Cheng, Halie Cook, Karma DaCosta, Joel Leininger, Kathleen McKeever, Stephen Weasel Scott, Devon Taylor, Katie Streicher, Steve Eck, Molly Reed, Raffaella Faggioni, Ronald Herbst, Rakesh Dixit, Patricia C Ryan
MEDI-570 is a fully human afucosylated monoclonal antibody (MAb) against Inducible T-cell costimulator (ICOS), highly expressed on CD4+ T follicular helper (TFH ) cells. Effects of MEDI-570 were evaluated in an enhanced pre-postnatal development toxicity (ePPND) study in cynomolgus monkeys. Administration to pregnant monkeys did not cause any abortifacient effects. Changes in hematology and peripheral blood T lymphocyte subsets in maternal animals and infants and the attenuated infant IgG immune response to keyhole limpet hemocyanin (KLH) were attributed to MEDI-570 pharmacology...
December 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28844740/back-to-the-future-rational-maps-for-exploring-acetylcholine-receptor-space-and-time
#14
REVIEW
Christian J G Tessier, Johnathon R Emlaw, Zhuo Qian Cao, F Javier Pérez-Areales, Jean-Paul J Salameh, Jethro E Prinston, Melissa S McNulty, Corrie J B daCosta
Global functions of nicotinic acetylcholine receptors, such as subunit cooperativity and compatibility, likely emerge from a network of amino acid residues distributed across the entire pentameric complex. Identification of such networks has stymied traditional approaches to acetylcholine receptor structure and function, likely due to the cryptic interdependency of their underlying amino acid residues. An emerging evolutionary biochemistry approach, which traces the evolutionary history of acetylcholine receptor subunits, allows for rational mapping of acetylcholine receptor sequence space, and offers new hope for uncovering the amino acid origins of these enigmatic properties...
August 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28825609/the-role-of-micrornas-in-the-chemopreventive-activity-of-sulforaphane-from-cruciferous-vegetables
#15
REVIEW
Christopher Dacosta, Yongping Bao
Colorectal cancer is an increasingly significant cause of mortality whose risk is linked to diet and inversely correlated with cruciferous vegetable consumption. This is likely to be partly attributable to the isothiocyanates derived from eating these vegetables, such as sulforaphane, which is extensively characterised for cytoprotective and tumour-suppressing activities. However, its bioactivities are likely to extend in complexity beyond those currently known; further insight into these bioactivities could aid the development of sulforaphane-based chemopreventive or chemotherapeutic strategies...
August 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28791328/a-feasibility-study-of-photoacoustic-imaging-of-ex-vivo-endoscopic-mucosal-resection-tissues-from-barrett-s-esophagus-patients
#16
Liang Lim, Catherine J Streutker, Norman Marcon, Maria Cirocco, Alexandra Lao, Vladimir V Iakovlev, Ralph DaCosta, Brian C Wilson
BACKGROUND AND STUDY AIMS : Accurate endoscopic detection of dysplasia in patients with Barrett's esophagus (BE) remains a major clinical challenge. The current standard is to take multiple biopsies under endoscopic image guidance, but this leaves the majority of the tissue unsampled, leading to significant risk of missing dysplasia. Furthermore, determining whether there is submucosal invasion is essential for proper staging. Hence, there is a clinical need for a rapid in vivo wide-field imaging method to identify dysplasia in BE, with the capability of imaging beyond the mucosal layer...
August 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28689969/ancestral-reconstruction-approach-to-acetylcholine-receptor-structure-and-function
#17
Jethro E Prinston, Johnathon R Emlaw, Mathieu F Dextraze, Christian J G Tessier, F Javier Pérez-Areales, Melissa S McNulty, Corrie J B daCosta
Acetylcholine receptors (AChRs) are members of a superfamily of proteins called pentameric ligand-gated ion channels, which are found in almost all forms of life and thus have a rich evolutionary history. Muscle-type AChRs are heteropentameric complexes assembled from four related subunits (α, β, δ, and ɛ). Here we reconstruct the amino acid sequence of a β subunit ancestor shared by humans and cartilaginous fishes (i.e., Torpedo). Then, by resurrecting this ancestral β subunit and co-expressing it with human α, δ, and ɛ subunits, we show that despite 132 substitutions, the ancestral subunit is capable of forming human/ancestral hybrid AChRs...
August 1, 2017: Structure
https://www.readbyqxmd.com/read/28670643/factors-associated-with-tb-hiv-co-infection-among-drug-sensitive-tuberculosis-patients-managed-in-a-secondary-health-facility-in-lagos-nigeria
#18
Olusola A Adejumo, Olusoji J Daniel, Andrew F Otesanya, Adebukola A Adegbola, Temitope Femi-Adebayo, Abimbola Bowale, Sunday Adesola, Olugbenga O Kuku, Kehinde O Otemuyiwa, Shafaatu N Oladega, Eze O Johnson, Ayodeji A Falana, Olusola Dawodu, Henry Owuna, Ganiyat Osoba, Adetokunbo Dacosta
BACKGROUND: This study assessed factors associated with TB/HIV co-infection among TB patients managed in a secondary health facility in Lagos Nigeria. MATERIALS AND METHODS: A retrospective review of treatment cards of patients seen at a secondary referral hospital between January 1 2014 and December 31 2014 was conducted. Treatment outcomes and factors associated with TB/HIV co-infection were assessed. RESULTS: Of the 334 records of patients reviewed, the proportion of patients with TB/HIV co-infection was 21...
2017: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28553128/a-retrospective-analysis-of-delays-in-the-diagnosis-of-lung-cancer-and-associated-costs
#19
Thomas R Gildea, Stacey DaCosta Byfield, D Kyle Hogarth, David S Wilson, Curtis C Quinn
PURPOSE: Diagnosis of lung cancer at advanced stages can result in missed treatment opportunities, worse outcomes, and higher health care costs. This study evaluated the wait time to diagnose non-small-cell lung cancer (NSCLC) and the cost of diagnosis and treatment based on the stage at diagnosis. PATIENTS AND METHODS: Adult patients diagnosed with NSCLC between January 2007 and September 2011 were identified from a proprietary oncology registry and linked to health insurance claims from a large US health insurance company...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28548309/tau-%C3%AE-synuclein-ratio-and-inflammatory-proteins-in-parkinson-s-disease-an-exploratory-study
#20
Manuel Delgado-Alvarado, Belén Gago, Ana Gorostidi, Haritz Jiménez-Urbieta, Rosalía Dacosta-Aguayo, Irene Navalpotro-Gómez, Javier Ruiz-Martínez, Alberto Bergareche, José F Martí-Massó, Pablo Martínez-Lage, Andrea Izagirre, María C Rodríguez-Oroz
BACKGROUND: No CSF or plasma biomarker has been validated for diagnosis or progression of PD. OBJECTIVES: To assess whether the CSF and plasma levels of proteins associated with PD neuropathological inclusions and with neuroinflammation might have value in the diagnosis of PD or in relation to disease severity. METHODS: CSF levels of α-synuclein, amyloid-ß1-42, total tau, and threonine-181 phosphorylated tau, as well as CSF and plasma levels of cytokines (interleukin-1ß, interleukin-2, interleukin, interferon-γ, and tumor necrosis factor α) were studied in 40 PD patients and 40 healthy controls...
July 2017: Movement Disorders: Official Journal of the Movement Disorder Society
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