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https://www.readbyqxmd.com/read/28322871/recurrent-emergence-of-structural-variants-of-ltr-retrotransposon-csrn1-evolving-novel-expression-strategy-and-their-selective-expansion-in-a-carcinogenic-liver-fluke-clonorchis-sinensis
#1
Seon-Hee Kim, Yoon Kong, Young-An Bae
Autonomous retrotransposons, in which replication and transcription are coupled, encode the essential gag and pol genes as a fusion or separate overlapping form(s) that are expressed in single transcripts regulated by a common upstream promoter. The element-specific expression strategies have driven development of relevant translational recoding mechanisms including ribosomal frameshifting to satisfy the protein stoichiometry critical for the assembly of infectious virus-like particles. Retrotransposons with different recoding strategies exhibit a mosaic distribution pattern across the diverse families of reverse transcribing elements, even though their respective distributions are substantially skewed towards certain family groups...
March 16, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28289269/epidemiological-investigation-of-parasitic-infection-of-schoolchildren-from-six-elementary-schools-in-sakon-nakhon-province-thailand
#2
Ryuichi Doi, Makoto Itoh, Somchai Chakhatrakan, Shoji Uga
We conducted an epidemiological study of intestinal parasitic infection in 572 schoolchildren aged 4 to 12 years old from six elementary schools in Sakon Nakhon Province, Thailand from June 2013 to August 2014. We collected fecal, blood, and urine samples to investigate parasitic infection and conducted a questionnaire survey. Soil samples were examined for egg contamination. Fecal examination, using the formalin-ether sedimentation method, revealed that 39% of schoolchildren were infected with eight genera and eight species of parasites; three nematodes, two trematodes, one cestode, and two protozoa...
February 15, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/28286026/clonorchis-sinensis-excretory-secretory-products-promote-the-migration-and-invasion-of-cholangiocarcinoma-cells-by-activating-the-integrin-%C3%AE-4-fak-src-signaling-pathway
#3
Jhang Ho Pak, Qudsia Bashir, In Ki Kim, Sung-Jong Hong, Sejung Maeng, Young Yil Bahk, Tong-Soo Kim
Cholangiocarcinoma (CCA) is a slow-growing but highly metastatic cancer. Its metastatic potential largely explains its high mortality rate. A recognized risk factor for CCA development is infection with the liver flukes Opisthorchis viverrini and Clonorchis sinensis. We previously reported that the excretory-secretory products (ESPs) of C. sinensis promoted the three-dimensional aggregation and invasion of CCA cells. In the present study, a quantitative real-time PCR array of extracellular matrix (ECM) and adhesion molecules was used to examine the regulatory mechanism of ESP-mediated CCA cell migration and invasion...
March 7, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28242064/opisthorchis-viverrini-infection-in-the-snail-and-fish-intermediate-hosts-in-central-vietnam
#4
Ha Thanh Thi Dao, Veronique Dermauw, Sarah Gabriël, Apiporn Suwannatrai, Smarn Tesana, Giang Thanh Thi Nguyen, Pierre Dorny
Opisthorchis viverrini, a carcinogenic fish borne fluke, requires freshwater snails and fish as intermediate hosts. Opisthorchiasis is endemic in parts of Southeast Asia, including Central and South Vietnam. In this region the transmission by intermediate hosts has received little attention. Therefore, freshwater snails and wild fish from Bau My Tho, an opisthorchiasis endemic area in Binh Dinh Province were collected for examination of O. viverrini cercariae and metacercariae, respectively. A total of 12,000 snails belonging to six families, of which 1616 Bithynia snails representing Bithynia siamensis goniomphalos and Bithynia funiculata; as well as 754 fish representing 12 species were examined...
February 24, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28238124/preliminary-genetic-evidence-of-two-different-populations-of-opisthorchis-viverrini-in-lao-pdr
#5
Opal Pitaksakulrat, Nadda Kiatsopit, Nonglak Laoprom, Bonnie L Webster, Joanne P Webster, Poppy H L Lamberton, Thewarach Laha, Ross H Andrews, Trevor N Petney, David Blair, Elizabeth J Carlton, Robert C Spear, Paiboon Sithithaworn
Opisthorchis viverrini is a major public health concern in Southeast Asia. Various reports have suggested that this parasite may represent a species complex, with genetic structure in the region perhaps being dictated by geographical factors and different species of intermediate hosts. We used four microsatellite loci to analyze O. viverrini adult worms originating from six species of cyprinid fish in Thailand and Lao PDR. Two distinct O. viverrini populations were observed. In Ban Phai, Thailand, only one subgroup occurred, hosted by two different fish species...
February 25, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28237890/experimental-and-modelling-investigations-of-opisthorchis-viverrini-miracidia-transmission-over-time-and-across-temperatures-implications-for-control
#6
Pierre Echaubard, Tomas León, Kulwadee Suwanatrai, Jukkrid Chaiyos, Christina S Kim, Frank F Mallory, Sasithorn Kaewkes, Robert C Spear, Banchob Sripa
Transmissibility is a significant factor in parasite fitness. The rate and magnitude of parasite transmission affect prevalence and infection intensity in individual hosts and are influenced by environmental factors. In this context, the objectives of this study were: (i) to experimentally assess Opisthorchis viverrini miracidia survival and infectivity over time and across temperatures; and (ii) to combine these experimental results with environmental data to build a key component of a transmission model, identifying seasonal windows of transmission risk in hyper-endemic northeastern Thailand...
February 23, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28237476/effects-of-albendazole-artesunate-praziquantel-and-miltefosine-on-opisthorchis-viverrini-cercariae-and-mature-metacercariae
#7
Phornphitcha Pechdee, Monticha Chaiyasaeng, Chanisala Sereewong, Jukkrid Chaiyos, Apiporn Suwannatrai, Sutee Wongmaneeprateep, Smarn Tesana
OBJECTIVE: To explore larvicidal effects of anthelmintic drugs on Opisthorchis viverrini (O. viverrini) for alternative approach to interrupting its cycle for developing a field-based control program. METHODS: The larvicidal activities of albendazole (Al), artesunate (Ar), praziquantel (Pzq) and miltefosine (Mf) on O. viverrini cercariae and mature metacercariae were investigated. Lethal concentrations (LC50 and LC95) of these drugs were determined. Mature metacercariae previously exposed to various concentrations of the drugs were administered to hamsters...
February 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28216369/role-of-socio-cultural-and-economic-factors-in-cyprinid-fish-distribution-networks-and-consumption-in-lawa-lake-region-northeast-thailand-novel-perspectives-on-opisthorchis-viverrini-transmission-dynamics
#8
Christina Sunyoung Kim, John F Smith, Apiporn Suwannatrai, Pierre Echaubard, Bruce Wilcox, Sasithorn Kaewkes, Paiboon Sithithaworn, Banchob Sripa
Opisthorchis viverrini (Ov) is a fish-borne parasite endemic in parts of Lao PDR, Cambodia, southern Vietnam and Northeast Thailand (Isaan) where an estimated 10 million people are infected. Human Ov infection, associated with hepatobiliary complications, including cholangiocarcinoma (CCA), occurs when infected fish are consumed raw or undercooked, a longstanding cultural tradition in the region. This mixed- methods descriptive study was carried out in Isaan villages around Lawa Lake, Khon Kaen Province, known for their Ov endemicity...
February 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28198451/elevated-prevalence-of-helicobacter-species-and-virulence-factors-in-opisthorchiasis-and-associated-hepatobiliary-disease
#9
Raksawan Deenonpoe, Eimorn Mairiang, Pisaln Mairiang, Chawalit Pairojkul, Yaovalux Chamgramol, Gabriel Rinaldi, Alex Loukas, Paul J Brindley, Banchob Sripa
Recent reports suggest that Opisthorchis viverrini serves as a reservoir of Helicobacter and implicate Helicobacter in pathogenesis of opisthorchiasis-associated cholangiocarcinoma (CCA). Here, 553 age-sex matched cases and controls, 293 and 260 positive and negative for liver fluke O. viverrini eggs, of residents in Northeastern Thailand were investigated for associations among infection with liver fluke, Helicobacter and hepatobiliary fibrosis. The prevalence of H. pylori infection was higher in O. viverrini-infected than uninfected participants...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28188767/social-network-analysis-of-food-sharing-among-households-in-opisthorchiasis-endemic-villages-of-lawa-lake-thailand
#10
Waraphon Phimpraphai, Sirikachorn Tangkawattana, Piya Sereerak, Suwicha Kasemsuwan, Banchob Sripa
Consumption of raw fish is a well-documented risk factor for Opisthorchis viverrini infection. Sharing of food, especially raw fish recipes may influence the spread of disease through a community. Using social network analysis of an ego network, we investigated food sharing among households in an Opisthorchis-endemic area. Network centrality properties were used to explain the differences in O. viverrini transmission and control between villages with a low and high prevalence of infection. Information on demography and O...
May 2017: Acta Tropica
https://www.readbyqxmd.com/read/28174906/efficacy-and-safety-of-praziquantel-against-light-infections-of-opisthorchis-viverrini-a-randomized-parallel-single-blind-dose-ranging-trial
#11
Somphou Sayasone, Isabel Meister, Jason R Andrews, Peter Odermatt, Youthanavanh Vonghachack, Syda Xayavong, Kanpaseuth Senggnam, Khampheng Phongluxa, Jan Hattendorf, Isaac I Bogoch, Jennifer Keiser
No abstract text is available yet for this article.
February 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28163802/nitrative-and-oxidative-dna-damage-in-infection-related-carcinogenesis-in-relation-to-cancer-stem-cells
#12
REVIEW
Shosuke Kawanishi, Shiho Ohnishi, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
Infection and chronic inflammation have been recognized as important factors for carcinogenesis. Under inflammatory conditions, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from inflammatory and epithelial cells, and result in the formation of oxidative and nitrative DNA lesions, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-nitroguanine. The DNA damage can cause mutations and has been implicated in inflammation-mediated carcinogenesis. It has been estimated that various infectious agents are carcinogenic to humans (IARC group 1), including bacterium Helicobacter pylori (H...
2017: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/28138021/co-infection-of-helicobacter-pylori-and-opisthorchis-viverrini-enhances-the-severity-of-hepatobiliary-abnormalities-in-hamsters
#13
Rungtiwa Dangtakot, Somchai Pinlaor, Upsornsawan Itthitaetrakool, Apisit Chaidee, Chariya Chomvarin, Arunnee Sangka, Chotechana Wilailuckana, Porntip Pinlaor
Persistent infection with Opisthorchis viverrini causes hepatobiliary abnormalities, predisposing infected individuals to cholangiocarcinoma (CCA). In addition, Helicobacter pylori is highly prevalent in most countries and is a possible risk factor for CCA; however, its role in enhancing hepatobiliary abnormality is unclear. Here, we investigated the effects of co-infection of H. pylori and O. viverrini on hepatobiliary abnormality. Hamsters were divided into four groups: (1) normal, (2) H. pylori-infected (HP), (3) O...
January 30, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28131825/targeting-hexokinase-ii-as-a-possible-therapy-for-cholangiocarcinoma
#14
Ubonrat Thamrongwaranggoon, Wunchana Seubwai, Chatchai Phoomak, Sakkarn Sangkhamanon, Ubon Cha'on, Thidarat Boonmars, Sopit Wongkham
Overexpression of hexokinase 2 (HKII) has been demonstrated in various cancers. A number of in vitro and in vivo studies in several cancers show the significance of HKII in many cellular processes including proliferation, metastasis and apoptosis. However, the role of HKII in Opisthorchis viverrini (Ov) associated cholangiocarcinoma (CCA) is still unknown. In the present study, the expression and roles of HKII were determined in Ov associated CCA. The expression of HKII was investigated in 82 patients with histologically proven CCAs by immunohistochemistry...
January 25, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28108370/application-of-environmental-dna-analysis-for-the-detection-of-opisthorchis-viverrini-dna-in-water-samples
#15
Hiroki Hashizume, Megumi Sato, Marcello Otake Sato, Sumire Ikeda, Tippayarat Yoonuan, Surapol Sanguankiat, Tiengkham Pongvongsa, Kazuhiko Moji, Toshifumi Minamoto
Opisthorchiasis, which can lead to cholangiocarcinoma in cases of chronic infection, is a major public health problem in Southeast Asian countries. The trematode, Opisthorchis viverrini, is the causative agent of the disease. Accurate and rapid monitoring of O. viverrini is crucial for disease prevention and containment. Therefore, in this study we sought to develop a novel species-specific real-time PCR assay for detecting O. viverrini using environmental DNA (eDNA). The diagnostic sensitivity of the newly developed real-time PCR assay was similar to that of the traditional PCR assay for 50 fecal samples collected in Lao PDR (21 and 19 samples were positive by real-time PCR and traditional PCR, respectively)...
May 2017: Acta Tropica
https://www.readbyqxmd.com/read/28105582/-control-of-opisthorchis-viverrini-infection-for-cholangiocarcinoma-prevention
#16
Y Buisson
The International Agency for Research on Cancer (IARC) has classified two liver flukes as carcinogenic to humans (Group 1): Opisthorchis viverrini in 1994 and Clonorchis sinensis in 2009. This review is focused on O. viverrini, the most studied of these two trematodes, which infects nearly 10 million people in Southeast Asia. The life cycle involves two intermediate hosts living in fresh water: a snail of the genus Bithynia and a ciprinid fish. The definitive hosts (human, cat, dog) become infected by ingesting raw fish containing metacercariae, the infective stage of the parasite...
January 19, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28043382/protozoan-and-helminth-parasite-fauna-of-free-living-croatian-wild-wolves-canis-lupus-analyzed-by-scat-collection
#17
Carlos Hermosilla, Sonja Kleinertz, Liliana M R Silva, Jörg Hirzmann, Djuro Huber, Josip Kusak, Anja Taubert
The European wolf (Canis lupus) is a large carnivore species present in limited areas of Europe with several small populations still being considered as endangered. Wolves can be infected by a wide range of protozoan and metazoan parasites with some of them affecting free-living wolf health condition. On this account, an epidemiological survey was conducted to analyze the actual parasite fauna in Croatian wild wolves. In total, 400 individual faecal samples were collected during field studies on wolf ecology in the years 2002-2011...
January 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28032359/opisthorchis-felineus-negatively-associates-with-skin-test-reactivity-in-russia-europrevall-inco-study
#18
Olga S Fedorova, Jacqueline J Janse, Ludmila M Ogorodova, Marina M Fedotova, Rogier A Achterberg, Jaco J Verweij, Montserrat Fernández-Rivas, Serge A Versteeg, James Potts, Cosetta Minelli, Ronald van Ree, Peter Burney, Maria Yazdanbakhsh
BACKGROUND: Most studies on the relationship between helminth infections and atopic disorders have been conducted in (sub)tropical developing countries where exposure to multiple parasites and lifestyle can confound the relationship. We aimed to study the relationship between infection with the fish-borne helminth Opishorchis felineus and specific IgE, skin prick testing and atopic symptoms in Western-Siberia, with lifestyle and hygiene standards of a developed country. METHODS: Schoolchildren aged 7 to 11 years were sampled from one urban and two rural regions...
December 29, 2016: Allergy
https://www.readbyqxmd.com/read/28030606/body-condition-peaks-at-intermediate-parasite-loads-in-the-common-bully-gobiomorphus-cotidianus
#19
Alberto Maceda-Veiga, Andy J Green, Robert Poulin, Clément Lagrue
Most ecologists and conservationists perceive parasitic infections as deleterious for the hosts. Their effects, however, depend on many factors including host body condition, parasite load and the life cycle of the parasite. More research into how multiple parasite taxa affect host body condition is required and will help us to better understand host-parasite coevolution. We used body condition indices, based on mass-length relationships, to test the effects that abundances and biomasses of six parasite taxa (five trematodes, Apatemon sp...
2016: PloS One
https://www.readbyqxmd.com/read/27989833/identification-and-characterization-of-protein-14-3-3-in-carcinogenic-liver-fluke-opisthorchis-viverrini
#20
Alok Kafle, Pranom Puchadapirom, Sirikanya Plumworasawat, Rieofarng Dontumprai, Waraporn Chan-On, Sureemas Buates, Thewarach Laha, Banchob Sripa, Sutas Suttiprapa
Protein 14-3-3s are abundant phospho-serine/threonine binding proteins, which are highly conserved among eukaryotes. Members of this protein family mediate metabolism and signal transduction networks through binding to hundreds of other protein partners. Protein 14-3-3s have been studied in other species of parasitic helminthes, but little is known about this protein in the carcinogenic liver fluke Opisthorchis viverrini. In this study, we identified and characterized protein 14-3-3s of O. viverrini. Seven protein 14-3-3 encoded sequences were retrieved from the O...
October 27, 2016: Parasitology International
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