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Opisthorchis

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https://www.readbyqxmd.com/read/29161330/fasciola-spp-mapping-of-the-mf6-epitope-and-antigenic-analysis-of-the-mf6p-hdm-family-of-heme-binding-proteins
#1
Victoria Martínez-Sernández, María J Perteguer, Mercedes Mezo, Marta González-Warleta, Teresa Gárate, M Adela Valero, Florencio M Ubeira
MF6p/FhHDM-1 is a small cationic heme-binding protein which is recognized by the monoclonal antibody (mAb) MF6, and abundantly present in parenchymal cells and secreted antigens of Fasciola hepatica. Orthologs of this protein (MF6p/HDMs) also exist in other causal agents of important foodborne trematodiasis, such as Clonorchis sinensis, Opisthorchis viverrini and Paragonimus westermani. Considering that MF6p/FhHDM-1 is relevant for heme homeostasis in Fasciola and was reported to have immunomodulatory properties, this protein is expected to be a useful target for vaccination...
2017: PloS One
https://www.readbyqxmd.com/read/29157282/updated-molecular-phylogenetic-data-for-opisthorchis-spp-trematoda-opisthorchioidea-from-ducks-in-vietnam
#2
Thanh Thi Ha Dao, Thanh Thi Giang Nguyen, Sarah Gabriël, Khanh Linh Bui, Pierre Dorny, Thanh Hoa Le
BACKGROUND: An opisthorchiid liver fluke was recently reported from ducks (Anas platyrhynchos) in Binh Dinh Province of Central Vietnam, and referred to as "Opisthorchis viverrini-like". This species uses common cyprinoid fishes as second intermediate hosts as does Opisthorchis viverrini, with which it is sympatric in this province. In this study, we refer to the liver fluke from ducks as "Opisthorchis sp. BD2013", and provide new sequence data from the mitochondrial (mt) genome and the nuclear ribosomal transcription unit...
November 21, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29153938/efficacy-and-safety-of-tribendimidine-versus-praziquantel-against-opisthorchis-viverrini-in-laos-an-open-label-randomised-non-inferiority-phase-2-trial
#3
Somphou Sayasone, Jennifer Keiser, Isabel Meister, Youthanavanh Vonghachack, Syda Xayavong, Kanpaseuth Senggnam, Khampheng Phongluxa, Jan Hattendorf, Peter Odermatt
BACKGROUND: Praziquantel is the only option for treatment of the liver fluke infection Opisthorchis viverrini. Tribendimidine could be an alternative drug. We aimed to assess the efficacy and safety of a single, oral dose of tribendimidine, compared with praziquantel administered in two doses, in participants with O viverrini infection. METHOD: We did an open-label, randomised, non-inferiority, phase 2 trial in children (8-14 years) and adolescents and adults (≥15 years) in Champasack province, southern Laos...
November 16, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29103267/intestinal-parasitic-infections-and-environmental-water-contamination-in-a-rural-village-of-northern-lao-pdr
#4
Alexis Ribas, Chloé Jollivet, Serge Morand, Boupha Thongmalayvong, Silaphet Somphavong, Chern-Chiang Siew, Pei-Jun Ting, Saipin Suputtamongkol, Viengsaene Saensombath, Surapol Sanguankiat, Boon-Huan Tan, Phimpha Paboriboune, Kongsap Akkhavong, Kittipong Chaisiri
A field survey studying intestinal parasites in humans and microbial pathogen contamination at environment was performed in a Laotian rural village to identify potential risks for disease outbreaks. A parasitological investigation was conducted in Ban Lak Sip village, Luang Prabang, Lao PDR involving fecal samples from 305 inhabitants as well as water samples taken from 3 sites of the local stream. Water analysis indicated the presence of several enteric pathogens, i.e., Aeromonas spp., Vibrio spp., E. coli H7, E...
October 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29095828/molecular-discrimination-of-opisthorchis-like-eggs-from-residents-in-a-rural-community-of-central-thailand
#5
Saiwasan Buathong, Saovanee Leelayoova, Mathirut Mungthin, Toon Ruang-Areerate, Tawee Naaglor, Picha Suwannahitatorn, Phunlerd Piyaraj, Paanjit Taamasri, Peerapan Tan-Ariya
BACKGROUND: Opisthorchis viverrini infection is a major public health problem in northern and northeastern Thailand. The chronic infection of O. viverrini is related to cholangiocarcinoma which causes high mortality in endemic areas. Therefore, the diagnosis, treatment, control and prevention of O. viverrini infection are necessary. The morphology of the egg is very similar to that of other species of human liver flukes (Opisthorchis felineus and Clonorchis sinensis) as well as that of small intestinal flukes in the family Heterophyidae...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29072436/a-large-scale-study-of-the-epidemiology-and-risk-factors-for-the-carcinogenic-liver-fluke-opisthorchis-viverrini-in-udon-thani-province-thailand
#6
Suksanti Prakobwong, Apiporn Suwannatrai, Achara Sancomerang, Suwit Chaipibool, Ngampis Siriwechtumrong
Opisthorchis viverrini infection and cholangiocarcinoma are serious problems in South East Asia. This study aimed to find the prevalence of opisthorchiasis in various hosts in Udon Thani Province. Total fecal samples were collected from 14,766 participants. The epidemiological data collected and analysed included prevalence and intensity of infection. Odds ratios (OR) were calculated to determine the associations between cross sectional data and to predict possible risk factors. The prevalence of O. viverrini infection in Udon Thani Province averaged 15...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29052139/parasite-associated-cancers-blood-flukes-liver-flukes
#7
Meng Feng, Xunjia Cheng
Parasitic infection remains as a persistent public health problem and can be carcinogenic. Three helminth parasites, namely, Clonorchis sinensis (liver fluke) and Opisthorchis viverrini as well as Schistosoma haematobium (blood fluke), are classified as Group 1 carcinogens by the World Health Organization's International Agency for Research on Cancer (IARC Infection with liver flukes (Opisthorchis viverrini, Opisthorchis felineus and Clonorchis sinensis), World Health Organization, International Agency for Research on Cancer, 2011)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29029597/identification-of-novel-natural-inhibitors-of-opisthorchis-felineus-cytochrome-p450-using-structure-based-screening-and-molecular-dynamic-simulation
#8
Rohit Shukla, Purna B Chetri, Amit Sonkar, Maria Y Pakharukova, Viatcheslav A Mordvinov, Timir Tripathi
Opisthorchis felineus is the etiological agent of opisthorchiasis in humans. O. felineus cytochrome P450 (OfCYP450) is an important enzyme in the parasite xenobiotic metabolism. To identify the potential anti-opisthorchid compound, we conducted a structure-based virtual screening of natural compounds from the ZINC database (n = 1,65,869) against the OfCYP450. The ligands were screened against OfCYP450 in four sequential docking modes that resulted in 361 ligands having better docking score. These compounds were evaluated for Lipinski and ADMET prediction, and 10 compounds were found to fit well with re-docking studies...
October 27, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28916307/extreme-conservation-of-mirna-complements-in-opisthorchiids
#9
Vladimir Y Ovchinnikov, Viatcheslav A Mordvinov, Bastian Fromm
MicroRNAs (miRNAs) are important gene regulators that are key players in animal development and diseases. They are excreted in extracellular vesicles and because they were shown to be taken up by host cells they have been proposed as mediators of parasite-host communication, and potential biomarkers for the detection of parasitic infections from host blood. Consequently, it is crucial to precisely know the miRNA complements of medically important agents such as the liver flukes of the Opisthorchiidae. Using publicly available and new datasets we curated and reannotated the surprisingly small and variable miRNA complements previously described for Opisthorchis viverrini, O...
December 2017: Parasitology International
https://www.readbyqxmd.com/read/28910999/infection-with-opisthorchis-felineus-induces-intraepithelial-neoplasia-of-the-biliary-tract-in-a-rodent-model
#10
Maria João Gouveia, Maria Y Pakharukova, Thewarach Laha, Banchob Sripa, Galina A Maksimova, Gabriel Rinaldi, Paul J Brindley, Viatcheslav A Mordvinov, Teresina Amaro, Lucio Lara Santos, José Manuel Correia da Costa, Nuno Vale
The liver fluke Opisthorchis felineus is a member of the triad of epidemiologically relevant species of the trematode family Opisthorchiidae, and the causative agent of opisthorchiasis felinea over an extensive range that spans regions of Eurasia. The International Agency for Research on Cancer classifies the infection with the liver flukes Opisthorchis viverrini and Clonorchis sinensis as group 1 agents and a major risk factor for cholangiocarcinoma. However, the carcinogenic potential of the infection with O...
September 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28866984/transmission-of-opisthorchis-viverrini-schistosoma-mekongi-and-soil-transmitted-helminthes-on-the-mekong-islands-southern-lao-pdr
#11
Youthanavanh Vonghachack, Peter Odermatt, Keoka Taisayyavong, Souphanh Phounsavath, Kongsap Akkhavong, Somphou Sayasone
BACKGROUND: Prevalence of Opisthorchis viverrini, Schistosoma mekongi and soil-transmitted helminths (STH) remains high in Lao People's Democratic Republic (Lao PDR), despite control efforts including mass-drug administration, education and communication campaigns. New approaches are required to advance helminth control. METHODS: An ecohealth study was conducted on two Mekong islands in Southern Laos. Demographic and behavioural data were collected by questionnaire...
September 4, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28795594/the-battle-of-worldviews-a-case-study-of-liver-fluke-infection-in-khon-kaen-thailand
#12
Sara Samiphak, S Leonard Syme
Control efforts to reduce infection from the parasitic flatworm Opisthorchis viverrini have progressed through understanding the epidemiology of Opisthorchis viverrini, antiparasitic drug developments, technological innovations, health education promoting cooking of fish, and improved hygienic defecation. Yet the problem persists. The case study method was used to examine the fundamental cause of the liver fluke infection problem. Evidence shows that the liver fluke-infected population does not care about living a long life...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28793922/comparison-of-novel-and-standard-diagnostic-tools-for-the-detection-of-schistosoma-mekongi-infection-in-lao-people-s-democratic-republic-and-cambodia
#13
Youthanavanh Vonghachack, Somphou Sayasone, Virak Khieu, Robert Bergquist, Govert J van Dam, Pytsje T Hoekstra, Paul L A M Corstjens, Beatrice Nickel, Hanspeter Marti, Jürg Utzinger, Sinuon Muth, Peter Odermatt
BACKGROUND: Given the restricted distribution of Schistosoma mekongi in one province in Lao People's Democratic Republic (Lao PDR) and two provinces in Cambodia, together with progress of the national control programmes aimed at reducing morbidity and infection prevalence, the elimination of schistosomiasis mekongi seems feasible. However, sensitive diagnostic tools will be required to determine whether elimination has been achieved. We compared several standard and novel diagnostic tools in S...
August 10, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28754415/prospects-and-challenges-towards-sustainable-liver-fluke-control
#14
REVIEW
Banchob Sripa, Pierre Echaubard
The liver fluke Opisthorchis viverrini (Ov) is endemic in Southeast Asia where more than 10 million people are estimated to be infected. The infection is associated with several hepatobiliary diseases, including cholangiocarcinoma (CCA). Northeast Thailand is a hotspot for Ov transmission, and, despite extensive public health prevention campaigns led by the government, the prevalence of Ov infection is still high. High infection rates result from cultural and ecological complexities where wet-rice agrarian habitats, centuries-old raw-food culture, and the parasite's complex biology combine to create an ideal transmission arena...
October 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28729070/abc-transporters-in-the-liver-fluke-opisthorchis-felineus
#15
Viatcheslav A Mordvinov, Nikita I Ershov, Darya S Pirozhkova, Yuri V Pakharukov, Maria Y Pakharukova
ATP-binding cassette transporters (ABC transporters) are essential components of normal cellular physiological machinery in all eukaryotic and prokaryotic species, including parasites. Some ABC transporters, e.g., P-glycoproteins, are involved in the efflux of toxins and xenobiotics from the cell. At present, nothing is known about ABC transporter genes in epidemiologically important liver flukes from the Opisthorchiidae family, including European liver fluke Opisthorchis felineus. Opisthorchiasis caused by O...
July 17, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28725936/ultrastructural-characters-of-the-spermatozoon-of-the-liver-fluke-opisthorchis-viverrini-poirier-1886-opisthorchiidae
#16
Jordi Miquel, Zdzisław Świderski, Banchob Sripa, Alexis Ribas
The present study records the ultrastructural organization of the mature spermatozoon of Opisthorchis viverrini by means of transmission electron microscopy. The spermatozoon of O. viverrini is a filiform cell, tapered at both extremities. It exhibits the characteristics of type IV spermatozoon of digeneans, namely with two axonemes of the 9+'1' trepaxonematan pattern, external ornamentation of the plasma membrane associated with cortical microtubules that are in the posterior part of the anterior region of the sperm cell, and with two mitochondria...
July 19, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28719954/subsets-of-inflammatory-cytokine-gene-polymorphisms-are-associated-with-risk-of-carcinogenic-liver-fluke-opisthorchis-viverrini-associated-advanced-periductal-fibrosis-and-cholangiocarcinoma
#17
Arpa Surapaitoon, Sutas Suttiprapa, Eimorn Mairiang, Narong Khuntikeo, Chawalit Pairojkul, Jeffrey Bethony, Paul J Brindley, Banchob Sripa
Opisthorchis viverrini infection induces chronic inflammation, and a minor proportion of infected individuals develop advanced periductal fibrosis (APF) and cholangiocarcinoma (CCA). Inflammatory cytokines and/or their gene polymorphisms may link to these biliary pathologies. We therefore investigated associations among cytokine gene polymorphisms and cytokine production in 510 Thai cases infected with O. viverrini who presented with APF+ or APF-, as established by abdominal ultrasonography as well as in patients diagnosed with CCA...
June 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28708894/magnetic-resonance-imaging-and-spectroscopy-for-differential-assessment-of-liver-abnormalities-induced-by-opisthorchis-felineus-in-an-animal-model
#18
Alexandra G Pershina, Vladimir V Ivanov, Lina V Efimova, Oleg B Shevelev, Sergey V Vtorushin, Tatjana V Perevozchikova, Alexey E Sazonov, Ludmila M Ogorodova
BACKGROUND: European liver fluke Opisthorchis felineus, causing opisthorchiasis disease, is widespread in Russia, Ukraine, Kazakhstan and sporadically detected in the EU countries. O. felineus infection leads to hepatobiliary pathological changes, cholangitis, fibrosis and, in severe cases, malignant transformation of bile ducts. Due to absence of specific symptoms, the infection is frequently neglected for a long period. The association of opisthorchiasis with almost incurable bile duct cancer and rising international migration of people that increases the risk of the parasitic etiology of liver fibrosis in non-endemic regions determine high demand for development of approaches to opisthorchiasis detection...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28699535/protein-kinases-as-targets-for-opisthorchis-viverrini-associated-cholangiocarcinoma-therapy
#19
Watcharin Loilome, Hasaya Dokduang
Protein kinases are enzymes that catalyze the transfer of phosphate from ATP to the serine/threonine or tyrosine residues of target molecules. These are key important mediators in a signaling cascade involved in several biological processes. Dysregulation of their activity has been found in various tumors. From our increased understanding of kinase structure and activation mechanisms there emerged new strategies for targeting kinase in cancer treatment. Nowadays, kinase specific inhibitors are developed and widely used for clinical cancer treatment...
July 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28669159/simplified-techniques-for-killing-the-carcinogenic-opisthorchis-viverrini-metacercariae-in-cyprinid-fish
#20
Panupan Sripan, Thidarut Boonmars, Jiraporn Songsri, Ratchadawan Aukkanimart, Pranee Sriraj, Panaratana Rattanasuwan, Parichart Boueroy, Apiporn Suwannatrai, Surasit Aunpromma, Narong Khuntikeo, Watcharin Loilome, Nisana Namwat, Puangrat Yongvanit, Aung PhyoWai, Sukhonthip Khueangchaingkhwang, Wu Zhilang, Benjamabhorn Pumhirunroj, Atchara Artchayasawat, Sirintip Boonjaraspinyo
Consumption of fluke-free fish is the most important factor in controlling Opisthorchis viverrini (OV) infection in endemic areas such as northeast Thailand and thereby reducing the risk of cholangiocarcinoma. Cooking fish is the best way to avoid infection; however, the cultural practice of eating raw or fermented fish is difficult to change. We investigated the food preparation process, using freezing, heating and fermentation to kill OV metacercariae in fish. Uncooked cyprinid fish infected with OV were divided into three groups: refrigerated at 4 oC for 24, 48 or 72 h (control group); frozen at -20 oC for 24, 48 or 72 h; or heated by microwaving (at 400 or 800 W) or boiling at 90 oC for 1, 5 or 10 min...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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