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https://www.readbyqxmd.com/read/29346089/genererating-a-core-cluster-of-fasciola-hepatica-virulence-and-immunomodulation-related-genes-using-a-comparative-in-silico-approach
#1
Orçun Haçarız, Gearóid P Sayers
A total of 71 virulence and immunomodulation-related transcripts (VIRs) of Fasciola hepatica have been previously proposed (Haçarız et al., 2015). In an attempt to further refine this cohort, an in silico meta analysis approach was carried out using publicly available sequence data of related liver flukes, Clonorchis sinensis and Opisthorchis viverrini. Data of both liver flukes were investigated in terms of sequential homology with data of non-parasitic organisms, pathogens and VIRs of F. hepatica, directional selection (Ka/Ks), and cytokine signaling relation (protein motif based)...
December 28, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29331794/melatonin-suppresses-eosinophils-and-th17-cells-in-hamsters-treated-with-a-combination-of-human-liver-fluke-infection-and-a-chemical-carcinogen
#2
Wachanan Wongsena, Lakhanawan Charoensuk, Rungtiwa Dangtakot, Porntip Pinlaor, Kitti Intuyod, Somchai Pinlaor
BACKGROUND: The combination of Opisthorchis viverrini (OV) infection and chemical carcinogen induces cholangiocarcinoma (CCA) in hamsters via inflammation-mediated mechanisms. Thus, suppression of inflammatory cells at the initial stages of CCA development would be of benefit. We aimed to investigate whether IL-17-producing CD4+ T cells (Th17) and CD4+ Foxp3+ T cells (Treg) are involved in the early stages of CCA genesis and can be targeted for suppression by melatonin. METHODS: Inflammation, an initial stage of CCA development, was induced in hamsters by a combination of O...
July 26, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29320819/molecular-and-biochemical-characterization-of-opisthorchis-viverrini-calreticulin
#3
Wanlapa Chaibangyang, Amornrat Geadkaew-Krenc, Suksiri Vichasri-Grams, Smarn Tesana, Rudi Grams
Calreticulin (CALR), a multifunctional protein thoroughly researched in mammals, comprises N-, P-, and C-domain and has roles in calcium homeostasis, chaperoning, clearance of apoptotic cells, cell adhesion, and also angiogenesis. In this study, the spatial and temporal expression patterns of the Opisthorchis viverrini CALR gene were analyzed, and calcium-binding and chaperoning properties of recombinant O. viverrini CALR (OvCALR) investigated. OvCALR mRNA was detected from the newly excysted juvenile to the mature parasite by RT-PCR while specific antibodies showed a wide distribution of the protein...
December 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29209530/teleconsultation-ultrasonography-a-new-weapon-to-combat-cholangiocarcinoma
#4
Nittaya Chamadol, Vallop Laopaiboon, Jiraporn Srinakarin, Watcharin Loilome, Puangrat Yongvanit, Bandit Thinkhamrop, Narong Khuntikeo
Although cholangiocarcinoma (CCA) is usually a rare cancer, in northeast Thailand it kills 20 000 or more people every year. The prognosis is very poor owing to late stage diagnosis, with palliative treatment often representing the only option. In this area of predominantly rural Thailand, CCA is associated with infection with the liver fluke, Opisthorchis viverrini, which is classified as a group 1 carcinogen. Up to 6 million Thais are infected with this fluke. The Cholangiocarcinoma Screening and Care Program (CASCAP) was initiated in 2014 with the aim of detecting early stage CCA, allowing curative surgery, by using ultrasound (US) screening of prospectively 500 000 at risk individuals...
2017: ESMO Open
https://www.readbyqxmd.com/read/29197514/mathematical-analysis-of-the-transmission-dynamics-of-the-liver-fluke-opisthorchis-viverrini
#5
Christine Bürli, Helmut Harbrecht, Peter Odermatt, Somphou Sayasone, Nakul Chitnis
We develop and analyse two population-based models of the transmission dynamics of the worm parasite Opisthorchis viverrini. The life cycle of O. viverrini includes humans, cats and dogs as definitive hosts; and snails and fish as intermediate hosts. The first model has only one definitive host (humans) while the second model has two additional hosts: the reservoir hosts, cats and dogs. We define reproduction numbers and endemic equilibrium points for the two models. We use prevalence data for the five hosts from two islands in Lao People's Democratic Republic to estimate distributions of parameter values...
November 29, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29191519/opisthorchis-felineus-infection-prevalence-in-western-siberia-a-review-of-russian-literature
#6
REVIEW
Olga S Fedorova, Marina M Fedotova, Tatiana S Sokolova, Ekaterina A Golovach, Yulia V Kovshirina, Tatiana S Ageeva, Anna E Kovshirina, Olga S Kobyakova, Ludmila M Ogorodova, Peter Odermatt
In this study we reviewed Russian scientific literature (scientific publications, book chapters, monographs) published between 1 January 1979 and 31 August 2015 from two sources: Main database of the Russian Scientific Electronic Library (eLIBRARY, http://elibrary.ru/), and the Scientific Medical Library of Siberian State Medical University (http://medlib.tomsk.ru/). Specifically, the review details the infection prevalence of Opisthorchis felineus (O. felineus) in Western Siberia, Russian Federation. From the primary key words screening, 1591 records were identified from which 32 Russian-language publications were relevant...
November 27, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29191517/potential-risk-of-a-liver-fluke-opisthorchis-viverrini-infection-brought-by-immigrants-from-prevalent-areas-a-case-study-in-the-lower-northern-thailand
#7
Wilawan Pumidonming, Hirotaka Katahira, Makoto Igarashi, Doaa Salman, Abdelbaset E Abdelbaset, Khamphon Sangkaeo
Considering the long lifespan of the liver fluke Opisthorchis viverrini, human mobility from prevalent regions to other neighboring areas has the possibility to disperse carriers and complicate the opisthorchiasis problem. To evaluate this, mass screening of the fluke infection was conducted in nine communities of lower Northern Thailand, combined with a questionnaire survey to distinguish the participant's origin. The liver fluke infection was found in 70 individuals (7.2%) of the examined 971 stool samples from seven communities, with light intensity providing small numbers of eggs in the examined stool...
November 27, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29161330/fasciola-spp-mapping-of-the-mf6-epitope-and-antigenic-analysis-of-the-mf6p-hdm-family-of-heme-binding-proteins
#8
Victoria Martínez-Sernández, María J Perteguer, Mercedes Mezo, Marta González-Warleta, Teresa Gárate, M Adela Valero, Florencio M Ubeira
MF6p/FhHDM-1 is a small cationic heme-binding protein which is recognized by the monoclonal antibody (mAb) MF6, and abundantly present in parenchymal cells and secreted antigens of Fasciola hepatica. Orthologs of this protein (MF6p/HDMs) also exist in other causal agents of important foodborne trematodiasis, such as Clonorchis sinensis, Opisthorchis viverrini and Paragonimus westermani. Considering that MF6p/FhHDM-1 is relevant for heme homeostasis in Fasciola and was reported to have immunomodulatory properties, this protein is expected to be a useful target for vaccination...
2017: PloS One
https://www.readbyqxmd.com/read/29157282/updated-molecular-phylogenetic-data-for-opisthorchis-spp-trematoda-opisthorchioidea-from-ducks-in-vietnam
#9
Thanh Thi Ha Dao, Thanh Thi Giang Nguyen, Sarah Gabriël, Khanh Linh Bui, Pierre Dorny, Thanh Hoa Le
BACKGROUND: An opisthorchiid liver fluke was recently reported from ducks (Anas platyrhynchos) in Binh Dinh Province of Central Vietnam, and referred to as "Opisthorchis viverrini-like". This species uses common cyprinoid fishes as second intermediate hosts as does Opisthorchis viverrini, with which it is sympatric in this province. In this study, we refer to the liver fluke from ducks as "Opisthorchis sp. BD2013", and provide new sequence data from the mitochondrial (mt) genome and the nuclear ribosomal transcription unit...
November 21, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29153938/efficacy-and-safety-of-tribendimidine-versus-praziquantel-against-opisthorchis-viverrini-in-laos-an-open-label-randomised-non-inferiority-phase-2-trial
#10
Somphou Sayasone, Jennifer Keiser, Isabel Meister, Youthanavanh Vonghachack, Syda Xayavong, Kanpaseuth Senggnam, Khampheng Phongluxa, Jan Hattendorf, Peter Odermatt
BACKGROUND: Praziquantel is the only option for treatment of the liver fluke infection Opisthorchis viverrini. Tribendimidine could be an alternative drug. We aimed to assess the efficacy and safety of a single, oral dose of tribendimidine, compared with praziquantel administered in two doses, in participants with O viverrini infection. METHOD: We did an open-label, randomised, non-inferiority, phase 2 trial in children (8-14 years) and adolescents and adults (≥15 years) in Champasack province, southern Laos...
November 16, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29103267/intestinal-parasitic-infections-and-environmental-water-contamination-in-a-rural-village-of-northern-lao-pdr
#11
Alexis Ribas, Chloé Jollivet, Serge Morand, Boupha Thongmalayvong, Silaphet Somphavong, Chern-Chiang Siew, Pei-Jun Ting, Saipin Suputtamongkol, Viengsaene Saensombath, Surapol Sanguankiat, Boon-Huan Tan, Phimpha Paboriboune, Kongsap Akkhavong, Kittipong Chaisiri
A field survey studying intestinal parasites in humans and microbial pathogen contamination at environment was performed in a Laotian rural village to identify potential risks for disease outbreaks. A parasitological investigation was conducted in Ban Lak Sip village, Luang Prabang, Lao PDR involving fecal samples from 305 inhabitants as well as water samples taken from 3 sites of the local stream. Water analysis indicated the presence of several enteric pathogens, i.e., Aeromonas spp., Vibrio spp., E. coli H7, E...
October 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29095828/molecular-discrimination-of-opisthorchis-like-eggs-from-residents-in-a-rural-community-of-central-thailand
#12
Saiwasan Buathong, Saovanee Leelayoova, Mathirut Mungthin, Toon Ruang-Areerate, Tawee Naaglor, Picha Suwannahitatorn, Phunlerd Piyaraj, Paanjit Taamasri, Peerapan Tan-Ariya
BACKGROUND: Opisthorchis viverrini infection is a major public health problem in northern and northeastern Thailand. The chronic infection of O. viverrini is related to cholangiocarcinoma which causes high mortality in endemic areas. Therefore, the diagnosis, treatment, control and prevention of O. viverrini infection are necessary. The morphology of the egg is very similar to that of other species of human liver flukes (Opisthorchis felineus and Clonorchis sinensis) as well as that of small intestinal flukes in the family Heterophyidae...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29072436/a-large-scale-study-of-the-epidemiology-and-risk-factors-for-the-carcinogenic-liver-fluke-opisthorchis-viverrini-in-udon-thani-province-thailand
#13
Suksanti Prakobwong, Apiporn Suwannatrai, Achara Sancomerang, Suwit Chaipibool, Ngampis Siriwechtumrong
Opisthorchis viverrini infection and cholangiocarcinoma are serious problems in South East Asia. This study aimed to find the prevalence of opisthorchiasis in various hosts in Udon Thani Province. Total fecal samples were collected from 14,766 participants. The epidemiological data collected and analysed included prevalence and intensity of infection. Odds ratios (OR) were calculated to determine the associations between cross sectional data and to predict possible risk factors. The prevalence of O. viverrini infection in Udon Thani Province averaged 15...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29052139/parasite-associated-cancers-blood-flukes-liver-flukes
#14
Meng Feng, Xunjia Cheng
Parasitic infection remains as a persistent public health problem and can be carcinogenic. Three helminth parasites, namely, Clonorchis sinensis (liver fluke) and Opisthorchis viverrini as well as Schistosoma haematobium (blood fluke), are classified as Group 1 carcinogens by the World Health Organization's International Agency for Research on Cancer (IARC Infection with liver flukes (Opisthorchis viverrini, Opisthorchis felineus and Clonorchis sinensis), World Health Organization, International Agency for Research on Cancer, 2011)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29029597/identification-of-novel-natural-inhibitors-of-opisthorchis-felineus-cytochrome-p450-using-structure-based-screening-and-molecular-dynamic-simulation
#15
Rohit Shukla, Purna B Chetri, Amit Sonkar, Maria Y Pakharukova, Viatcheslav A Mordvinov, Timir Tripathi
Opisthorchis felineus is the etiological agent of opisthorchiasis in humans. O. felineus cytochrome P450 (OfCYP450) is an important enzyme in the parasite xenobiotic metabolism. To identify the potential anti-opisthorchid compound, we conducted a structure-based virtual screening of natural compounds from the ZINC database (n = 1,65,869) against the OfCYP450. The ligands were screened against OfCYP450 in four sequential docking modes that resulted in 361 ligands having better docking score. These compounds were evaluated for Lipinski and ADMET prediction, and 10 compounds were found to fit well with re-docking studies...
October 27, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28916307/extreme-conservation-of-mirna-complements-in-opisthorchiids
#16
Vladimir Y Ovchinnikov, Viatcheslav A Mordvinov, Bastian Fromm
MicroRNAs (miRNAs) are important gene regulators that are key players in animal development and diseases. They are excreted in extracellular vesicles and because they were shown to be taken up by host cells they have been proposed as mediators of parasite-host communication, and potential biomarkers for the detection of parasitic infections from host blood. Consequently, it is crucial to precisely know the miRNA complements of medically important agents such as the liver flukes of the Opisthorchiidae. Using publicly available and new datasets we curated and reannotated the surprisingly small and variable miRNA complements previously described for Opisthorchis viverrini, O...
December 2017: Parasitology International
https://www.readbyqxmd.com/read/28910999/infection-with-opisthorchis-felineus-induces-intraepithelial-neoplasia-of-the-biliary-tract-in-a-rodent-model
#17
Maria João Gouveia, Maria Y Pakharukova, Thewarach Laha, Banchob Sripa, Galina A Maksimova, Gabriel Rinaldi, Paul J Brindley, Viatcheslav A Mordvinov, Teresina Amaro, Lucio Lara Santos, José Manuel Correia da Costa, Nuno Vale
The liver fluke Opisthorchis felineus is a member of the triad of epidemiologically relevant species of the trematode family Opisthorchiidae, and the causative agent of opisthorchiasis felinea over an extensive range that spans regions of Eurasia. The International Agency for Research on Cancer classifies the infection with the liver flukes Opisthorchis viverrini and Clonorchis sinensis as group 1 agents and a major risk factor for cholangiocarcinoma. However, the carcinogenic potential of the infection with O...
September 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28866984/transmission-of-opisthorchis-viverrini-schistosoma-mekongi-and-soil-transmitted-helminthes-on-the-mekong-islands-southern-lao-pdr
#18
Youthanavanh Vonghachack, Peter Odermatt, Keoka Taisayyavong, Souphanh Phounsavath, Kongsap Akkhavong, Somphou Sayasone
BACKGROUND: Prevalence of Opisthorchis viverrini, Schistosoma mekongi and soil-transmitted helminths (STH) remains high in Lao People's Democratic Republic (Lao PDR), despite control efforts including mass-drug administration, education and communication campaigns. New approaches are required to advance helminth control. METHODS: An ecohealth study was conducted on two Mekong islands in Southern Laos. Demographic and behavioural data were collected by questionnaire...
September 4, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28795594/the-battle-of-worldviews-a-case-study-of-liver-fluke-infection-in-khon-kaen-thailand
#19
Sara Samiphak, S Leonard Syme
Control efforts to reduce infection from the parasitic flatworm Opisthorchis viverrini have progressed through understanding the epidemiology of Opisthorchis viverrini, antiparasitic drug developments, technological innovations, health education promoting cooking of fish, and improved hygienic defecation. Yet the problem persists. The case study method was used to examine the fundamental cause of the liver fluke infection problem. Evidence shows that the liver fluke-infected population does not care about living a long life...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28793922/comparison-of-novel-and-standard-diagnostic-tools-for-the-detection-of-schistosoma-mekongi-infection-in-lao-people-s-democratic-republic-and-cambodia
#20
Youthanavanh Vonghachack, Somphou Sayasone, Virak Khieu, Robert Bergquist, Govert J van Dam, Pytsje T Hoekstra, Paul L A M Corstjens, Beatrice Nickel, Hanspeter Marti, Jürg Utzinger, Sinuon Muth, Peter Odermatt
BACKGROUND: Given the restricted distribution of Schistosoma mekongi in one province in Lao People's Democratic Republic (Lao PDR) and two provinces in Cambodia, together with progress of the national control programmes aimed at reducing morbidity and infection prevalence, the elimination of schistosomiasis mekongi seems feasible. However, sensitive diagnostic tools will be required to determine whether elimination has been achieved. We compared several standard and novel diagnostic tools in S...
August 10, 2017: Infectious Diseases of Poverty
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