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https://www.readbyqxmd.com/read/28440978/methylation-status-of-p16ink4a-in-human-papillomavirus-associated-cancer-of-oral-cavity-and-oropharynx-in-northeastern-thailand
#1
Piyawut Swangphon, Chamsai Pientong, Ati Burassakarn, Patravoot Vatanasapt, Pilaiwan Kleebkaow, Natcha Patarapadungkit, Thanabut Treebupachatsakul, Supannee Promthet, Bunkerd Kongyingyoes, Tipaya Ekalaksananan
Background: Over-expression of p16INK4a protein is a biomarker for human papillomavirus (HPV)-associated cervical cancer. However, absence of p16INK4a protein expression in HPV-associated cancer of the oral cavity and oropharynx has been reported. Among a number of possible reasons for this is methylation, which is frequently noted in the promoter region of p16INK4a and is associated with silencing of the gene and disease severity. Methods: We investigated the relationships between p16INK4a protein expression, HPV infection and methylation status of the p16INK4a promoter in cancers of the oral cavity and oropharynx...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28431957/genetic-study-of-kir-and-hla-ligands-in-235-individuals-from-northeastern-thailand
#2
Suwit Chaisri, Chanvit Leelayuwat, Amornrat Romphruk
The diversity of 17 KIR and HLA ligands (HLA-C1, C2, Bw4, A11) were investigated in two hundred and thirty-five unrelated healthy donors in Northeastern Thais (NETs) by the polymerase chain reaction with sequence-specific primer (PCR-SSP) method. The Hardy-Weinberg Equilibrium (HWE) was used to verify genotyping method for dimorphic KIR and HLA. They were in HWE (p>0.05). KIR and HLA ligands frequencies, genotypes, haplotypes and linkage disequilibrium (LD) were presented. The genetic data are available in allele Frequencies Net Database...
April 18, 2017: Human Immunology
https://www.readbyqxmd.com/read/28412524/antimicrobial-resistance-and-genetic-diversity-of-the-sxt-element-in-vibrio-cholerae-from-clinical-and-environmental-water-samples-in-northeastern-thailand
#3
Wanida Mala, Kiatichai Faksri, Kittipan Samerpitak, Umaporn Yordpratum, Wanlop Kaewkes, Unchalee Tattawasart, Chariya Chomvarin
Multidrug resistance in V. cholerae has been increasing around the world including northeastern Thailand. The aquatic environment is a reservoir of V. cholerae and might be an important source of resistant strains. The aims of this study were to investigate the phylogenetic relationships of intSXT gene sequences from 31 clinical and 14 environmental V. cholerae O1 and non-O1/non-O139 isolates and 11 sequences amplified directly from environmental water samples. We also amplified class 1 integrons, the SXT elements (targeting the intSXT gene) and antimicrobial resistance genes directly from water samples...
April 13, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28372560/fish-sharing-as-a-risk-factor-for-opisthorchis-viverrini-infection-evidence-from-two-villages-in-north-eastern-thailand
#4
Parichat Saenna, Cameron Hurst, Pierre Echaubard, Bruce A Wilcox, Banchob Sripa
BACKGROUND: Foodborne trematodiasis (FBT) is a significant global health problem, with the liver flukes Opisthorchis viverrini, O. felineus, and Clonorchis sinensis contributing to half of the global burden of FBT. North-eastern Thailand where O. viverrini is endemic and un-cooked fish dishes remain an integral part of the food culture has the highest reported incidence of opisthorchiasis, including associated cholangiocarcinoma. Both food sharing and eating practices are potentially important factors in FTB, suggesting an important role for the social ecology of disease transmission in these rural communities...
April 4, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28353659/a-pharmacological-examination-of-the-cardiovascular-effects-of-malayan-krait-bungarus-candidus-venoms
#5
Janeyuth Chaisakul, Muhamad Rusdi Ahmad Rusmili, Wayne C Hodgson, Panadda Hatthachote, Kijja Suwan, Anjaree Inchan, Lawan Chanhome, Iekhsan Othman, Krongkarn Chootip
Cardiovascular effects (e.g., tachycardia, hypo- and/or hypertension) are often clinical outcomes of snake envenoming. Malayan krait (Bungarus candidus) envenoming has been reported to cause cardiovascular effects that may be related to abnormalities in parasympathetic activity. However, the exact mechanism for this effect has yet to be determined. In the present study, we investigated the in vivo and in vitro cardiovascular effects of B. candidus venoms from Southern (BC-S) and Northeastern (BC-NE) Thailand...
March 29, 2017: Toxins
https://www.readbyqxmd.com/read/28347653/cytochrome-c-oxidase-subunit-i-haplotype-diversity-of-angiostrongylus-cantonensis-nematoda-angiostrongylidae
#6
Praphathip Eamsobhana, Sze-Looi Song, Hoi-Sen Yong, Anchana Prasartvit, Sudarat Boonyong, Anchalee Tungtrongchitr
The rat lungworm Angiostrongylus cantonensis is a food-borne zoonotic parasite of public health importance worldwide. It is the primary etiologic agent of eosinophilic meningitis and eosinophilic meningoencephalitis in humans in many countries. It is highly endemic in Thailand especially in the northeast region. In this study, A. cantonensis adult worms recovered from the lungs of wild rats in different geographical regions/provinces in Thailand were used to determine their haplotype by means of the mitochondrial partial cytochrome c oxidase subunit I (COI) gene sequence...
March 27, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28345841/carcinogenic-liver-fluke-and-others-contaminated-in-pickled-fish-of-northeastern-thailand
#7
Ratchadawan Aukkanimart, Thidarut Boonmars, Pranee Sriraj, Panupan Sripan, Jiraporn Songsri, Panaratana Ratanasuwan, Porntip Laummaunwai, Apiporn Suwanantrai, Surasit Aunpromma, Sukhonthip Khueangchaingkhwang, Benjamabhorn Pumhirunroj, Atchara Artchayasawat, Narong Khuntikeo, Watcharin Loilome, Nisana Namwat, Puangrat Yongvanit, Sirintip Boonjaraspinyo
Twenty provinces in northeastern Thailand were investigated for fluke metacercariae contamination in pickled fish, or pla-som, during January –June 2016. A total of 129 pickled fish shops were randomly chosen. Samples were digested with acid-pepsin and those found to be infected with metacercariae were fed to hamsters to test for metacercariae infectivity. The results demonstrated that only 20.2% of the pla-som samples were infected with fluke metacercariae (mc), at various levels (1 to 268 mc/kg). All recovered fluke metacercariae were inactive, degenerated and could not develop to adults in the animal model...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28339543/climatic-factors-and-prevalence-of-campylobacter-in-commercial-broiler-flocks-in-thailand
#8
S Prachantasena, P Charununtakorn, S Muangnoicharoen, L Hankla, N Techawal, P Chaveerach, P Tuitemwong, N Chokesajjawatee, N Williams, T Humphrey, T Luangtongkum
Campylobacter are bacteria associated with human foodborne disease worldwide. Poultry and poultry products are generally considered as a main source of these organisms. Compared to temperate zones, baseline information on Campylobacter in tropical regions is limited. Thus, the objectives of the present study were 1) to determine the prevalence of Campylobacter in Thai broiler flocks and 2) to investigate the association between climatic factors (i.e., rainfall, ambient temperature, and relative humidity) and Campylobacter colonization status of broiler flocks in Thailand...
October 6, 2016: Poultry Science
https://www.readbyqxmd.com/read/28284223/genetic-diversity-of-taenia-saginata-cestoda-cyclophyllidea-from-lao-people-s-democratic-republic-and-northeastern-thailand-based-on-mitochondrial-dna
#9
Oranuch Sanpool, Rutchanee Rodpai, Pewpan M Intapan, Lakkhana Sadaow, Tongjit Thanchomnang, Sakhone Laymanivong, Wanchai Maleewong, Hiroshi Yamasaki
BACKGROUND: Taenia saginata is a tapeworm found in cattle worldwide. Analysis of genetic diversity in different geographical populations of T. saginata not only helps to understand the origin, transmission and spread of this organism, but also to evaluate the selection pressures acting on T. saginata and how it is responding to them. However, there are few reports of the genetic variability of T. saginata populations in different regions of the world, including Lao PDR and Thailand. We report the genetic diversity of T...
March 11, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28237890/experimental-and-modelling-investigations-of-opisthorchis-viverrini-miracidia-transmission-over-time-and-across-temperatures-implications-for-control
#10
Pierre Echaubard, Tomas León, Kulwadee Suwanatrai, Jukkrid Chaiyos, Christina S Kim, Frank F Mallory, Sasithorn Kaewkes, Robert C Spear, Banchob Sripa
Transmissibility is a significant factor in parasite fitness. The rate and magnitude of parasite transmission affect prevalence and infection intensity in individual hosts and are influenced by environmental factors. In this context, the objectives of this study were: (i) to experimentally assess Opisthorchis viverrini miracidia survival and infectivity over time and across temperatures; and (ii) to combine these experimental results with environmental data to build a key component of a transmission model, identifying seasonal windows of transmission risk in hyper-endemic northeastern Thailand...
April 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28216665/interleukin-10-inhibits-pro-inflammatory-cytokine-responses-and-killing-of-burkholderia-pseudomallei
#11
Bianca Kessler, Darawan Rinchai, Chidchamai Kewcharoenwong, Arnone Nithichanon, Rachael Biggart, Catherine M Hawrylowicz, Gregory J Bancroft, Ganjana Lertmemongkolchai
Melioidosis, caused by Burkholderia pseudomallei, is endemic in northeastern Thailand and Northern Australia. Severe septicemic melioidosis is associated with high levels of pro-inflammatory cytokines and is correlated with poor clinical outcomes. IL-10 is an immunoregulatory cytokine, which in other infections can control the expression of pro-inflammatory cytokines, but its role in melioidosis has not been addressed. Here, whole blood of healthy seropositive individuals (n = 75), living in N. E. Thailand was co-cultured with B...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28198451/elevated-prevalence-of-helicobacter-species-and-virulence-factors-in-opisthorchiasis-and-associated-hepatobiliary-disease
#12
Raksawan Deenonpoe, Eimorn Mairiang, Pisaln Mairiang, Chawalit Pairojkul, Yaovalux Chamgramol, Gabriel Rinaldi, Alex Loukas, Paul J Brindley, Banchob Sripa
Recent reports suggest that Opisthorchis viverrini serves as a reservoir of Helicobacter and implicate Helicobacter in pathogenesis of opisthorchiasis-associated cholangiocarcinoma (CCA). Here, 553 age-sex matched cases and controls, 293 and 260 positive and negative for liver fluke O. viverrini eggs, of residents in Northeastern Thailand were investigated for associations among infection with liver fluke, Helicobacter and hepatobiliary fibrosis. The prevalence of H. pylori infection was higher in O. viverrini-infected than uninfected participants...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28161569/the-spread-of-artemisinin-resistant-plasmodium-falciparum-in-the-greater-mekong-subregion-a-molecular-epidemiology-observational-study
#13
Mallika Imwong, Kanokon Suwannasin, Chanon Kunasol, Kreepol Sutawong, Mayfong Mayxay, Huy Rekol, Frank M Smithuis, Tin Maung Hlaing, Kyaw M Tun, Rob W van der Pluijm, Rupam Tripura, Olivo Miotto, Didier Menard, Mehul Dhorda, Nicholas P J Day, Nicholas J White, Arjen M Dondorp
BACKGROUND: Evidence suggests that the PfKelch13 mutations that confer artemisinin resistance in falciparum malaria have multiple independent origins across the Greater Mekong subregion, which has motivated a regional malaria elimination agenda. We aimed to use molecular genotyping to assess antimalarial drug resistance selection and spread in the Greater Mekong subregion. METHODS: In this observational study, we tested Plasmodium falciparum isolates from Myanmar, northeastern Thailand, southern Laos, and western Cambodia for PfKelch13 mutations and for Pfplasmepsin2 gene amplification (indicating piperaquine resistance)...
May 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28112468/self-care-behaviors-and-trajectory-management-by-people-with-scleroderma-in-northeastern-thailand
#14
Promjit Hornboonherm, Ratanavadee Nanagara, Apinya Kochamat, Oratai Wantha
Scleroderma, particularly systemic sclerosis, is a chronic illness that affects a person's physical, emotional, psychosocial, and spiritual dimensions. To investigate self-care deficits, health behaviors, and trajectory management of Thai people with systemic sclerosis, an exploratory case study method was used through interviews and patient records. Self-care deficit nursing theory and the chronic illness trajectory framework guided the research. Twelve patients with systemic sclerosis were purposively recruited at a hospital clinic in the northeastern region of Thailand...
January 23, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/28028631/molecular-detection-and-genetic-diversity-of-bovine-babesia-spp-theileria-orientalis-and-anaplasma-marginale-in-beef-cattle-in-thailand
#15
Charoonluk Jirapattharasate, Paul Franck Adjou Moumouni, Shinuo Cao, Aiko Iguchi, Mingming Liu, Guanbo Wang, Mo Zhou, Patrick Vudriko, Artemis Efstratiou, Tanasak Changbunjong, Sivapong Sungpradit, Parntep Ratanakorn, Walasinee Moonarmart, Poonyapat Sedwisai, Thekhawet Weluwanarak, Witsanu Wongsawang, Hiroshi Suzuki, Xuenan Xuan
Babesia spp., Theileria orientalis, and Anaplasma marginale are significant tick-borne pathogens that affect the health and productivity of cattle in tropical and subtropical areas. In this study, we used PCR to detect the presence of Babesia bovis, Babesia bigemina, and T. orientalis in 279 beef cattle from Western Thailand and A. marginale in 608 beef cattle from the north, northeastern, and western regions. The PCRs were performed using species-specific primers based on the B. bovis spherical body protein 2 (BboSBP2), B...
February 2017: Parasitology Research
https://www.readbyqxmd.com/read/27977663/getting-road-expansion-on-the-right-track-a-framework-for-smart-infrastructure-planning-in-the-mekong
#16
Andrew Balmford, Huafang Chen, Ben Phalan, Mingcheng Wang, Christine O'Connell, Cath Tayleur, Jianchu Xu
The current unprecedented expansion of infrastructure promises to enhance human wellbeing but risks causing substantial harm to natural ecosystems and the benefits they provide for people. A framework for systematically and proactively identifying the likely benefits and costs of such developments is badly needed. Here, we develop and test at the subregional scale a recently proposed global scheme for comparing the potential gains from new roads for food production with their likely impact on biodiversity and ecosystem services...
December 2016: PLoS Biology
https://www.readbyqxmd.com/read/27935063/human-papillomavirus-hpv-infection-in-a-case-control-study-of-oral-squamous-cell-carcinoma-and-its-increasing-trend-in-northeastern-thailand
#17
Pensiri Phusingha, Tipaya Ekalaksananan, Patravoot Vatanasapt, Kulchaya Loyha, Supannee Promthet, Bunkerd Kongyingyoes, Natcha Patarapadungkit, Jureeporn Chuerduangphui, Chamsai Pientong
Human papillomavirus (HPV) is an independent risk factor for development of oral squamous cell carcinoma (OSCC). This study aimed to investigate the role of HPV infection and the trend in percentage of HPV-associated OSCC over a 5-year period in northeastern Thailand. In this case-control study, 91 exfoliated oral cell samples and 80 lesion cell samples from OSCC cases and exfoliated oral cells from 100 age/gender-matched controls were collected. HPV infection was investigated by PCR using GP5+/GP6+ primers followed by HPV genotyping using reverse line blot hybridization...
December 9, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27825353/analysis-of-anti-malarial-resistance-markers-in-pfmdr1-and-pfcrt-across-southeast-asia-in-the-tracking-resistance-to-artemisinin-collaboration
#18
Krongkan Srimuang, Olivo Miotto, Pharath Lim, Rick M Fairhurst, Dominic P Kwiatkowski, Charles J Woodrow, Mallika Imwong
BACKGROUND: Declining anti-malarial efficacy of artemisinin-based combination therapy, and reduced Plasmodium falciparum susceptibility to individual anti-malarials are being documented across an expanding area of Southeast Asia (SEA). Genotypic markers complement phenotypic studies in assessing the efficacy of individual anti-malarials. METHODS: The markers pfmdr1 and pfcrt were genotyped in parasite samples obtained in 2011-2014 at 14 TRAC (Tracking Resistance to Artemisinin Collaboration) sites in mainland Southeast Asia using a combination of PCR and next-generation sequencing methods...
November 8, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27797250/flt3-itd-mutations-in-acute-myeloid-leukemia-patients-in-northeast-thailand
#19
Piyawan Kumsaen, Goonnapa Fucharoen, Chittima Sirijerachai, Su-On Chainansamit, Nittaya Wisanuyothin, Pichayanan Kuwatjanakul, Surapon Wiangnon
The FLT3-ITD mutation is one of the most frequent genetic abnormalities in acute myeloid leukemia (AML) where it is associated with a poor prognosis. The FLT3-ITD mutation could, therefore, be a potential molecular prognostic marker important for risk-stratified treatment options. We amplified the FLT3 gene at exon 14 and 15 in 52 AML patients (aged between 2 months and 74 years) from 4 referral centers (a university hospital and 3 regional hospitals in Northeast Thailand), using a simple PCR method. FLT3-ITD mutations were found in 10 patients (19...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27769299/ex-vivo-piperaquine-resistance-developed-rapidly-in-plasmodium-falciparum-isolates-in-northern-cambodia-compared-to-thailand
#20
Suwanna Chaorattanakawee, Chanthap Lon, Krisada Jongsakul, Jariyanart Gawee, Somethy Sok, Siratchana Sundrakes, Nareth Kong, Chatchadaporn Thamnurak, Soklyda Chann, Sorayut Chattrakarn, Chantida Praditpol, Nillawan Buathong, Nichapat Uthaimongkol, Philip Smith, Narongrid Sirisopana, Rekol Huy, Satharath Prom, Mark M Fukuda, Delia Bethell, Douglas S Walsh, Charlotte Lanteri, David Saunders
BACKGROUND: The recent dramatic decline in dihydroartemisinin-piperaquine (DHA-PPQ) efficacy in northwestern Cambodia has raised concerns about the rapid spread of piperaquine resistance just as DHA-PPQ is being introduced as first-line therapy in neighbouring countries. METHODS: Ex vivo parasite susceptibilities were tracked to determine the rate of progression of DHA, PPQ and mefloquine (MQ) resistance from sentinel sites on the Thai-Cambodian and Thai-Myanmar borders from 2010 to 2015...
October 21, 2016: Malaria Journal
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