Thatcha Yimthin, Rungnapa Phunpang, Shelton W Wright, Ekkachai Thiansukhon, Seksan Chaisuksant, Ploenchan Chetchotisakd, Kittisak Tanwisaid, Somchai Chuananont, Chumpol Morakot, Narongchai Sangsa, Wirayut Silakun, Sunee Chayangsu, Noppol Buasi, Ganjana Lertmemongkolchai, Narisara Chantratita, T Eoin West
Melioidosis, infection caused by Burkholderia pseudomallei, is characterized by robust innate immune responses. We have previously reported associations of TLR1 single nucleotide missense variant rs76600635 with mortality and of TLR5 nonsense variant rs5744168 with both bacteremia and mortality in single-center studies of patients with melioidosis in northeastern Thailand. The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients...
March 19, 2024: American Journal of Tropical Medicine and Hygiene