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Khushnooda Ramzan, Mohammed Al-Owain, Rozeena Huma, Selwa A F Al-Hazzaa, Sarah Al-Ageel, Faiqa Imtiaz, Moeenaldeen Al-Sayed
Next generation sequencing (NGS), such as targeted panel sequencing, whole-exome sequencing and whole-genome sequencing has led to an exponential increase of elucidated genetic causes in both rare diseases, and common but heterogeneous disorders. NGS is applied in both research and clinical settings, and the clinical exome sequencing (CES), which provides not only the sequence variation data but also clinical interpretation, aids in reaching a final conclusion with regards to a genetic diagnosis. Usher syndrome is a group of disorders, characterized by bilateral sensorineural hearing loss, with or without vestibular dysfunction and retinitis pigmentosa...
May 2018: International Journal of Pediatric Otorhinolaryngology
Murad Aljiffry, Razan Habib, Eman Kotbi, Amro Ageel, Mazen Hassanain, Yaser Dahlan
PURPOSE: This study was carried out because intragastric balloon (IGB) is a widely used method to combat obesity, and acute pancreatitis complicating IGB is rare and yet to be understood. METHOD: This study was a retrospective analysis of all patients with a history of IGB insertion, who developed acute pancreatitis before balloon removal. RESULTS: A total of 4 cases were found, with a mean age of 27±2.9 years. The mean duration of IGB insertion was 2...
December 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Mohamed S Mahfouz, Abdulwahab Aqeeli, Anwar M Makeen, Ramzi M Hakami, Hatim H Najmi, Abdullkarim T Mobarki, Mohammad H Haroobi, Saeed M Almalki, Mohammad A Mahnashi, Osayd A Ageel
The issue of mental health literacy has been widely studied in developed countries, with few studies conducted in Arab countries. In this study we aimed to investigate mental health literacy and attitudes towards psychiatric patients among students of Jazan University, Kingdom of Saudi Arabia. A crosssectional study was conducted among undergraduate students using a validated Arabicversion questionnaire. A total of 557 students were recruited from different Jazan university colleges. The majority of students (90...
November 23, 2016: Mental Illness
F Al-Saif, A Elisa, A Al-Homidy, A Al-Ageel, M Al-Mubarak
BACKGROUND AND OBJECTIVES: Pemphigoid gestationis (PG) is a rare autoimmune-mediated blistering disease that mainly affects pregnant women in their 2nd or 3rd trimester and immediate postpartum period. In addition to the clinical assessment, the diagnosis of PG is usually confirmed by histological and immunological studies. PG usually flares up at the time of delivery and spontaneously improves postpartum. Prompt recognition and appropriate management may reduce morbidity associated with this disorder...
August 2016: Journal of Reproductive Immunology
Shamimul Hasan, Sami Faisal Jamdar, Jogender Jangra, Sadun Mohammad Al Ageel Al Beaiji
Melanomais one of the most dreaded and aggressive neoplasms, being derived from epidermal melanocytes. The majority of melanomas are seen to involve the skin, and primary mucosal melanomas account for less than 1% of all melanomas. Oral malignant melanomas (OMM) are asymptomatic at the initial presentation, but later they become painful with growth and expansion. In the late stages, the patient may present with ulceration, bleeding, tooth mobility, paresthesia, ill-fitting prosthesis, and delayed healing of the extraction sockets...
March 2016: Journal of International Society of Preventive & Community Dentistry
Shamimul Hasan, Sami Faisal Jamdar, Munther Alalowi, Sadun Mohammad Al Ageel Al Beaiji
Dengue is an acute viral illness caused by RNA virus of the family Flaviviridae and spread by Aedes mosquitoes. Presenting features may range from asymptomatic fever to dreaded complications such as hemorrhagic fever and shock. A cute-onset high fever, muscle and joint pain, myalgia, cutaneous rash, hemorrhagic episodes, and circulatory shock are the commonly seen symptoms. Oral manifestations are rare in dengue infection; however, some cases may have oral features as the only presenting manifestation. Early and accurate diagnosis is critical to reduce mortality...
January 2016: Journal of International Society of Preventive & Community Dentistry
Ravindra B Pathak, Benjamin C Dobson, Nandita Ghosh, Khalid A Ageel, Madeha R Alshawish, Rungroj Saruengkhanphasit, Iain Coldham
An efficient synthetic approach to the core structure of the manzamine alkaloids is reported, particularly in relation to incorporating a one-carbon unit in ring B from which the aldehyde in ircinal A or the beta-carboline unit in manzamine A could potentially be generated. The key steps involve a Johnson-Claisen rearrangement, enolate alkylation, dithiane alkylation and a stereoselective intramolecular dipolar cycloaddition of an azomethine ylide, which provided the desired tricyclic ABC core structure.
March 21, 2015: Organic & Biomolecular Chemistry
Ahmed I Albarrak, Eman Abdulrahman Al Rashidi, Rwaa Kamil Fatani, Shoog Ibrahim Al Ageel, Rafiuddin Mohammed
OBJECTIVES: To assess the legibility and completeness of handwritten prescriptions and compare with electronic prescription system for medication errors. DESIGN: Prospective study. SETTING: King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia. SUBJECTS AND METHODS: Handwritten prescriptions were received from clinical units of Medicine Outpatient Department (MOPD), Primary Care Clinic (PCC) and Surgery Outpatient Department (SOPD) whereas electronic prescriptions were collected from the pediatric ward...
December 2014: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
M Al Sebayel, A M Alenazi, R Sabbagh, T Al Ageel, M Al Enazi, H Al Bahili, H Elsiesy
INTRODUCTION: Current organ supply system depends on altruistic noncoercive donation, which has failed to meet the demand of organ transplantation. Providing financial incentives to donors is one of several approaches to address organ shortage. However, its feasibility is debatable as it relates to medical, ethical, and economic dimensions. An incentive-based procurement system (IBPS) applied by the Mobile Donor Action Team (MDAT) was instituted in Riyadh, Saudi Arabia, resulting in a 3-fold increase in donation rate...
July 2014: Transplantation Proceedings
Saleh Al-Ageel, Abdulrahman M Al-Muammar
PURPOSE: To compare central corneal thickness (CCT) measurements taken with Pentacam, noncontact specular microscope (NCSM), and ultrasound pachymetry (US) in normal and post-laser in situ keratomileusis (LASIK) eyes and to assess the agreement between the three devices. DESIGN: Prospective clinical trial. PATIENTS AND METHODS: Central corneal thickness (CCT) was measured in 94 eyes of normal volunteer and in 72 eyes of post-LASIK patients...
October 2009: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Nahla A Al-Ageel, Sinaa A Al-Aqeel, Norah O Abanmy, Jamal S Alwakeel, Alaa Sabry, Khalid A Alsaran
UNLABELLED: The anemia of end stage renal disease (ESRD) is common and often severe complication that can be managed successfully by erythropoiesis-stimulating agents (ESA) administration. AIMS: To investigate current practice of anemia management in hemodialysis patients and to assess the appropriateness of anemia management by comparing observed practice to the Kidney Disease Outcomes Quality Initiative (KDOQI) guideline recommendations. SETTINGS AND DESIGN: The study was conducted at two hemodialysis centers in Riyadh, Saudi Arabia...
January 2012: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Sonia H Yoo, Saleh Al-Ageel
PURPOSE: To describe a case of a 52-year-old man with severe keratoconus who underwent femtosecond laser-assisted keratoplasty with the WaveLight FS200 femtosecond laser (Alcon Laboratories Inc). METHODS: The donor and recipient corneas were cut in a mushroom-shaped pattern. The laser parameters used on this platform for the donor and recipient corneas are described. RESULTS: Corrected distance visual acuity improved by 3 weeks postoperatively...
November 2012: Journal of Refractive Surgery
M A Al-Yahya, J S Mossa, A M Ageel, S Rafatullah
An ethanolic extract of Cress (Lepidium sativum L.) seeds has been studied for anti-inflammatory, antipyretic and analgesic activities and to evaluate the safety of their acute and chronic use in rodents. The extract significantly inhibited carrageenan-induced paw edema and reduced the yeast-induced hyperpyrexia. It also prolonged the reaction time of mice on the hot plate. However, the extract exacerbated indomethacin-induced gastric mucosal damage. The coagulation studies showed a significant increase in fibrinogen level and an insignificant decrease in prothrombin time, confirming its coagulating property...
September 1994: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Ageel J Al-Ghamdi, Khalid A Al-Turki, Nadira A Al-Baghli, Ahmad G El-Zubaier
OBJECTIVE: To describe a community-based diabetes and hypertension screening campaign, the percentage of screened positive individuals, identified the participation rate, and the factors affecting the participation. CAMPAIGN DESIGN AND METHODS: A community-based screening campaign whose main objective was the screening for diabetes and hypertension was conducted in the Eastern Province of Saudi Arabia for three and half months in the year 2004. A structured questionnaire was used. Diabetes mellitus was diagnosed on the basis of repeated detection of a fasting blood sugar equal to or more than 126 mg/dl, and hypertension when the blood pressure was 140/90 mm Hg or more...
September 2007: Journal of Family & Community Medicine
Nikola Kraljik, Marinela Rosso, Ala Ageel, Tatjana Sepić, Rudika Gmajnić
The aim of this study is to show the incidence of squamous cell carcinoma of the skin in Osijek Baranja County, Eastern Croatia, in period from 2004 to 2009. This is the first report of epidemiological features of squamous cell skin carcinoma in this region. In this period we registered 469 patients with SCC of the skin, from which 237 females (50.5%) and 232 males (49.5%). World age-standardised rates (ASRW per 100,000) incidence in this period was 11.8/100,000 (16.8/ 100,000 for men and 9.0/100,000 for women)...
September 2011: Collegium Antropologicum
A H Shah, M A Al-Yahya, A M El-Sayed, M Tariq, A M Ageel
The 14-membered cyclopeptide alkaloid mauritine-C and the 13-membered cyclopeptide alkaloid sativanine-C were isolated from Zizyphus spinea-christi and Zizyphus sativa commonly used in the Saudi Folklor medicine. The N-formyl derivatives of these compounds were prepared and their corresponding spectral data was analyzed. Fundamental differences were observed in the mass spectrometric fragmentation of the newly formed derivatives as compared to the parent compounds mass spectrometry was found a useful tool to substantiate the fragmentation pattern proposed for these potential natural products...
July 1989: Pakistan Journal of Pharmaceutical Sciences
A Khatibi, A H Shah, A M Ageel, M S Ahmad, M A Al-Yahya, M Tariq
Plants of 25 families, encompassing 30 species were selected on the basis of their folklore uses and literature data for the present screening. Besides phytochemical screening the plant extracts were prepared and tested for their antimicrobial activity. The result of the testing showed that about 77% of these plants exhibited some level of antibacterial activity. The most common chemical constituents found in these plants were sterols and/or triterpenes, falvonoids, alkaloids and tannins. Volatile oils, volatile bases, saponins, coumarins, anthraquinones and cardiac glycosides were also detected...
January 1989: Pakistan Journal of Pharmaceutical Sciences
A H Shah, A Katibi, A M Ageel, M O Tanira
Thirty-two plants species belonging to 22 families commonly used in Saudi folk medicine were subjected to phytochemical and antimicrobial screening. The results showed that sterols/triterpenes, flavonoids and tannins were the most common constituents. Volatile oils, volatile bases, coumarins, anthraquinones and cardiac glycosides were also detected. A variable range of antimicrobial activity was observed by the extracts and MIC's were determined wherever activity was noticed.
January 1988: Pakistan Journal of Pharmaceutical Sciences
Ayobanji E Ayoola, Mohsen S Tobaigy, Mohammed O Gadour, Basher S Ahmad, Margani K Hamza, Abdurahim M Ageel
OBJECTIVE: Hepatitis B virus (HBV) infection is endemic in the Kingdom of Saudi Arabia (KSA). The Jizan region in the South-Western area of the country was noted for a high prevalence of hepatitis B surface antigen (HbsAg) carrier rate. The study was carried out to determine the prevalence of HBsAg and other markers of HBV among residents of Jizan and evaluate the impact of the measures adopted in the last decade, to control HBV. METHODS: The study was carried out between 1995 and 1998...
September 2003: Saudi Medical Journal
H W Ghalib, S Al-Ghamdi, M Akood, A E Haridi, A A Ageel, R E Abdalla
The results of annual random screening indicated that Plasmodium falciparum strains showing chloroquine (CQ) resistance in vitro became increasingly common in the Jazan region of south-western Saudi Arabia between 1986 and 1998 (chi(2) for trend = 50.027; P < 0.001). This worrying trend and the emergence of a micro-epidemic in 1997-1998 prompted an assessment of the therapeutic efficacy of CQ against uncomplicated, P. falciparum malaria in the area. The in-vivo testing of sensitivity to CQ was carried out in 291 clinically manifest, microscopically positive cases of P...
December 2001: Annals of Tropical Medicine and Parasitology
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