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https://www.readbyqxmd.com/read/29138824/genetic-mutational-testing-of-chinese-children-with-familial-hematuria-with-biopsy%C3%A2-proven-fsgs
#1
Yongzhen Li, Ying Wang, Qingnan He, Xiqiang Dang, Yan Cao, Xiaochuan Wu, Shuanghong Mo, Xiaoxie He, Zhuwen Yi
Focal segmental glomerulosclerosis (FSGS) is a pathological lesion rather than a disease, with a diverse etiology. FSGS may result from genetic and non‑genetic factors. FSGS is considered a podocyte disease due to the fact that in the majority of patients with proven‑FSGS, the lesion results from defects in the podocyte structure or function. However, FSGS does not result exclusively from podocyte‑associated genes, however also from other genes including collagen IV‑associated genes. Patients who carry the collagen type IVA3 chain (COL4A3) or COL4A4 mutations usually exhibit Alport Syndrome (AS), thin basement membrane neuropathy or familial hematuria (FH)...
November 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29069915/aspartic-acid-derivatized-hydroxylated-fullerenes-as-drug-delivery-vehicles-for-docetaxel-an-explorative-study
#2
Nagarani Thotakura, Gajanand Sharma, Bhupinder Singh, Vipin Kumar, Kaisar Raza
The objective of the present study was to deliver docetaxel to cancerous cells with enhanced efficacy and safety profile, using aspartic acid linked fullerenols. This aspartic acid derivatized fullerenol conjugate linked with docetaxel was characterized by UV, FT-IR and NMR spectroscopy. Studies for particle size, PDI, zeta potential and FE-SEM were also performed. The conjugate was evaluated for release kinetics, cancer cell cytotoxicity, cellular uptake using confocal laser microscopy and also for pharmacokinetic profile...
October 25, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29068756/long-term-effect-of-pulsed-nd-yag-laser-combined-with-exercise-on-bone-mineral-density-in-men-with-osteopenia-or-osteoporosis-1-year-of-follow-up
#3
Mohamed Salaheldien Mohamed Alayat, Ehab Mohamed Abdel-Kafy, Ali Abdel Monsif Thabet, Ahmed Salman Abdel-Malek, Tariq Helmi Ali, Eslam A Header
BACKGROUND: A pulsed Nd-YAG laser is an effective physiotherapy modality used as a class IV high-intensity laser therapy (HILT). PURPOSE: The aim of this study is to investigate the efficacy of HILT alone or combined with exercise (HILT+EX) on bone mineral density (BMD) after 24 weeks and at 1 year of follow-up in men with osteopenia or osteoporosis. METHODS: One hundred men with osteopenia or osteoporosis (mean age, 53.78 [2.89] years; weight, 80...
October 25, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29027866/magnetic-resonance-imaging-guided-laser-interstitial-thermal-therapy-as-treatment-for-intractable-insular-epilepsy-in-children
#4
M Scott Perry, David J Donahue, Saleem I Malik, Cynthia G Keator, Angel Hernandez, Rohit K Reddy, Freedom F Perkins, Mark R Lee, Dave F Clarke
OBJECTIVE Seizure onset within the insula is increasingly recognized as a cause of intractable epilepsy. Surgery within the insula is difficult, with considerable risks, given the rich vascular supply and location near critical cortex. MRI-guided laser interstitial thermal therapy (LiTT) provides an attractive treatment option for insular epilepsy, allowing direct ablation of abnormal tissue while sparing nearby normal cortex. Herein, the authors describe their experience using this technique in a large cohort of children undergoing treatment of intractable localization-related epilepsy of insular onset...
October 13, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28895157/laryngeal-exposure-and-margin-status-in-glottic-cancer-treated-by-transoral-laser-microsurgery
#5
Cesare Piazza, Alberto Paderno, Paola Grazioli, Francesca Del Bon, Nausica Montalto, Pietro Perotti, Riccardo Morello, Marta Filauro, Piero Nicolai, Giorgio Peretti
OBJECTIVE: Laryngeal exposure is one of the most limiting factors in transoral laser microsurgery (TLM) for glottic cancer. We evaluated the correlation between the degree of laryngeal exposure, as assessed by an easy previously described scoring tool (Laryngoscore), and histopathologic surgical margin status after TLM. STUDY DESIGN: Prospective evaluation of 147 patients affected by Tis-T2 glottic cancer treated by TLM with curative intent between January 2012 and April 2016...
September 12, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28625446/a-novel-treatment-for-chronic-opioid-use-after-surgery
#6
Paul F White, Ofelia Loani Elvir-Lazo, Hector Hernandez
In a recent article from the Center for Disease Control, the authors addressed the current opioid epidemic in America and emphasized the importance of utilizing non-opioid analgesic alternatives to opioid medication for treating chronic pain. In cases where non-opioid analgesic drugs alone have failed to produce adequate pain relief, these authors suggested that non-pharmacologic therapies should also be considered. This Case Series describes a pilot study designed to evaluate a novel non-pharmacologic approach to treating long-standing (>1year) opioid dependency...
August 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28574039/-peripheral-perfusion-in-cad-patients-with-various-stage-chronic-heart-failure-undergoing-coronary-artery-bypass-grafting
#7
O V Kamenskaia, A S Klinkova, D V Khabarov
Using the orthostatic test, we examined peripheral perfusion by means of laser Doppler flowmetry (LDF) and transcutaneous oximetry in a total of 104 patients presenting with coronary artery disease and functional class II-IV chronic heart failure (CHF) prior to coronary artery bypass grafting (CABG) and in the remote terms thereafter. Volumetric velocity of the microcirculatory blood flow (MCB) of the lower limbs was measured by means of LDF in perfusion units; partial oxygen pressure (TcPO2, mmHg) was registered by means of transcutaneous oximetry...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27825283/physical-chemical-properties-of-furosemide-nanocrystals-developed-using-rotation-revolution-mixer
#8
Sávio Fujita Barbosa, Takayuki Takatsuka, Guilherme Diniz Tavares, Gabriel Lima Barros Araújo, Hui Wang, Reinhard Vehring, Raimar Löbenberg, Nádia Araci Bou-Chacra
Recently, several approaches have been reported to improve the dissolution rate and bioavailability of furosemide, a class IV drug. However, to the best of our knowledge, none of them proposed nanocrystals. In the last decade, nanocrystals successfully addressed solubility issues by increasing surface area and saturation solubility, both leading to an increase in the dissolution rate of poor water soluble drugs. The preparation of furosemide nanocrystals was by a rotation revolution mixer method. Size distribution and morphology were performed using laser diffraction and scanning electron microscopy, respectively...
November 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27170594/high-recurrence-of-device-related-adverse-events-following-transvenous-lead-extraction-procedure-in-patients-with-cardiac-resynchronization-devices
#9
François Regoli, Maria Grazia Bongiorni, Roberto Rordorf, Matteo Santamaria, Caterine Klersy, Luca Segreti, Valentina De Regibus, Tiziano Moccetti, Giulio Conte, Maria Luce Caputo, Angelo Auricchio
INTRODUCTION: Little is known about the clinical outcome and recurring system-related adverse events (SAE) in cardiac resynchronization therapy (CRT) patients after transvenous lead extraction (TLE). METHODS AND RESULTS: From January 2009 to June 2014, 256 consecutive CRT patients (mean age 68.3 ± 11.6 years, 216 male, 88% in New York Heart Association class II-IV, ejection fraction 35.1 ± 10.8%) were treated at four European institutions with TLE. Indications for TLE included systemic (18%) or local (45%) infection, system malfunction (34%), or other (3%)...
October 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27103012/bile-salt-micelles-and-phospholipid-vesicles-present-in-simulated-and-human-intestinal-fluids-structural-analysis-by-flow-field-flow-fractionation-multiangle-laser-light-scattering
#10
Philipp A Elvang, Askell H Hinna, Joachim Brouwers, Bart Hens, Patrick Augustijns, Martin Brandl
Knowledge about colloidal assemblies present in human intestinal fluids (HIFs), such as bile salt micelles and phospholipid vesicles, is regarded of importance for a better understanding of the in vivo dissolution and absorption behavior of poorly soluble drugs (Biopharmaceutics Classification System class II/IV drugs) because of their drug-solubilizing ability. The characterization of these potential drug-solubilizing compartments is a prerequisite for further studies of the mechanistic interplays between drug molecules and colloidal structures within HIFs...
September 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26796710/same-strategy-for-pitfalls-of-radiotherapy-in-different-anatomical-districts
#11
Margherita Gobbo, Giulia Ottaviani, Katia Rupel, Francesca Ciriello, Aulo Beorchia, Roberto Di Lenarda, Serena Zacchigna, Matteo Biasotto
Oral mucositis (OM) and radiodermatitis (RD) are serious side effects of radiotherapy (RT), often leading to its suspension, need for analgesics, and enteral/parenteral nutrition. Laser therapy is becoming a recommended treatment option. This prospective study aimed at demonstrating the beneficial effect of class IV laser therapy (HPLT) on RT-induced OM, an off-label use of HPLT to treat RD in breast cancer patients. Fifty-three cancer patients, during/after RT and/or chemotherapy (CT), affected by OM, were treated with HPLT during four consecutive days (970 ± 15 nm, 5 W (50 %), 35-6000 Hz, 240 s)...
April 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/26355716/in-vitro-study-on-the-safety-of-near-infrared-laser-therapy-in-its-potential-application-as-postmastectomy-lymphedema-treatment
#12
Francesca Cialdai, Ida Landini, Sergio Capaccioli, Stefania Nobili, Enrico Mini, Matteo Lulli, Monica Monici
Clinical studies demonstrated the effectiveness of laser therapy in the management of postmastectomy lymphedema, a discomforting disease that can arise after surgery/radiotherapy and gets progressively worse and chronic. However, safety issues restrict the possibility to treat cancer patients with laser therapy, since the effects of laser radiation on cancer cell behavior are not completely known and the possibility of activating postmastectomy residual cancer cells must be considered. This paper reports the results of an in vitro study aimed to investigate the effect of a class IV, dual-wavelength (808 nm and 905 nm), NIR laser system on the behavior of two human breast adenocarcinoma cell lines (namely, MCF7 and MDA-MB361 cell lines), using human dermal fibroblasts as normal control...
October 2015: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/26347062/treatments-for-traumatic-brain-injury-with-emphasis-on-transcranial-near-infrared-laser-phototherapy
#13
REVIEW
Larry D Morries, Paolo Cassano, Theodore A Henderson
Traumatic brain injury (TBI) is a growing health concern affecting civilians and military personnel. In this review, treatments for the chronic TBI patient are discussed, including pharmaceuticals, nutraceuticals, cognitive therapy, and hyperbaric oxygen therapy. All available literature suggests a marginal benefit with prolonged treatment courses. An emerging modality of treatment is near-infrared (NIR) light, which has benefit in animal models of stroke, spinal cord injury, optic nerve injury, and TBI, and in human trials for stroke and TBI...
2015: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/26257591/kienbock-disease-a-complicated-postsurgical-case-study-using-diagnostic-ultrasonography
#14
Alicia M Yochum, Norman W Kettner
OBJECTIVE: The purpose of this case report is to describe a case of Kienbock disease (lunatomalacia) that was identified through diagnostic ultrasonography. CLINICAL FEATURES: A 27-year-old man presented to a chiropractic teaching clinic with a 3-year history of wrist pain. The history of chief concern consisted of lunatomalacia, diagnosed 2 years prior, with surgical intervention consisting of radial osteotomy and vascularized bone graft. Radiography and ultrasonography were performed upon presentation and at 2-year follow-up that demonstrated progressive collapse and fragmentation of his lunate with the development of progressive scapholunate advanced collapse of the wrist...
June 2015: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/26249524/mr-guided-laser-interstitial-thermal-therapy-for-pediatric-drug-resistant-lesional-epilepsy
#15
Evan Cole Lewis, Alexander G Weil, Michael Duchowny, Sanjiv Bhatia, John Ragheb, Ian Miller
OBJECTIVE: To report the feasibility, safety, and clinical outcomes of an exploratory study of MR-guided Laser Interstitial Thermal Therapy (MRgLITT) as a minimally invasive surgical procedure for the ablation of epileptogenic foci in children with drug-resistant, lesional epilepsy. METHODS: Retrospective chart review of all MRgLITT procedures at a single tertiary care center. All procedures were performed using a U.S. Food and Drug Administration (FDA)-cleared surgical laser ablation system (Visualase Thermal Therapy System)...
October 2015: Epilepsia
https://www.readbyqxmd.com/read/26139735/assessment-of-feasibility-and-efficacy-of-class-iv-laser-therapy-for-postoperative-pain-relief-in-off-pump-coronary-artery-bypass-surgery-patients-a-pilot-study
#16
Anil Karlekar, Saswata Bharati, Ravindra Saxena, Kanchan Mehta
BACKGROUND: Laser therapy, for its established analgesic properties with minimal side effects, has been used for the treatment of chronic pain. However, it has not been used for the treatment of acute postoperative pain. This pilot study was designed to assess the feasibility and efficacy of Class IV laser on postoperative pain relief following off-pump coronary artery bypass graft (OPCABG) surgery, as a component of multimodal analgesia (MMA) technique. METHODS: This open observational prospective study comprised of 100 adult patients (84 male, 16 female) who underwent OPCABG through sternotomy...
July 2015: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/26125863/osteoprotegerin-polymorphisms-in-chinese-han-patients-with-rheumatoid-arthritis
#17
X H Ye, J L Cheng, R P Liu
In order to investigate the association between osteoprotegerin (OPG) gene polymorphisms and rheumatoid arthritis (RA), we studied OPG rs3102735 T/C and rs2073618 G/C polymorphisms in a Chinese Han population comprising 574 patients with RA and 804 controls. Genotyping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was conducted. Our data indicated that OPG rs3102735 T/C and rs2073618 G/C polymorphisms were not associated with the risk of RA. However, among older patients (≥55 years), patients with the OPG rs3102735 TC (TC vs TT: OR = 0...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/25990064/transmyocardial-laser-revascularization-histopathological-findings
#18
K Dedic, T Klima, D A Cooley, O H Frazier, K A Kadipasaoglu, H B Cihan
Transmyocardial laser revascularization (TMLR) is a new surgical technique clinically tested in patients with advanced severe coronary arteriosclerosis when classic routine treatment by medicaments, percutaneous transluminal coronary angioplasty (PTCA), or aorto-coronary bypass surgery does not improve symptoms of ischemic heart disease. During the procedure high-energy CO 2 laser performs 35-40 transmyocardial channels via left-sided thoracotomy. Channels are drilled from the epicardial side of the heart through the myocardium into the left ventricle cavity...
March 1998: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/25721946/transmyocardial-laser-revascularization-versus-medical-therapy-for-refractory-angina
#19
REVIEW
Eduardo Briones, Juan Ramon Lacalle, Ignacio Marin-Leon, José-Ramón Rueda
BACKGROUND: This is an update of a review previously published in 2009. Chronic angina and advanced forms of coronary disease are increasingly more frequent. In spite of the improvement in the efficacy of available revascularization treatments, a subgroup of patients continue suffering from refractory angina. Transmyocardial laser revascularization (TMLR) has been proposed to improve the clinical situation of these patients. OBJECTIVES: To assess the effects (both benefits and harms) of TMLR versus optimal medical treatment in people with refractory angina who are not candidates for percutaneous coronary angioplasty or coronary artery bypass graft, in alleviating angina severity, reducing mortality and improving ejection fraction...
February 27, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25685123/ultrasonography-and-radiography-to-identify-early-post-traumatic-myosistis-ossificans-in-an-18-year-old-male-a-case-report
#20
Alicia M Yochum, Kenneth Reckelhoff, Martha Kaeser, Norman W Kettner
OBJECTIVE: The purpose of this case report is to describe a patient with post traumatic myositis ossificans (PTMO) of the anterior thigh following blunt trauma and discuss the incidence, clinical presentation, management, and imaging findings. CLINICAL FEATURES: An 18-year-old male presented to a chiropractic clinic with a chief complaint of left knee pain and reduced range of motion after an impact injury to his left anterior thigh during hurdling 6 weeks earlier...
June 2014: Journal of Chiropractic Medicine
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