Shuangshuang Gao, Huili Li, Lixuan Liu, Yiming Tian, Rui Wang, Xuanlin Pan, Fusheng Wen, Jianyong Xiang, Anmin Nie, Kun Zhai, Bochong Wang, Congpu Mu, Tianyu Xue, Zhongyuan Liu
The accurate diagnosis of diabetic nephropathy relies on achieving ultrasensitive biosensing for biomarker detection. However, existing biosensors face challenges such as poor sensitivity, complexity, time-consuming procedures, and high assay costs. To address these limitations, we report a WS2 -based plasmonic biosensor for the ultrasensitive detection of biomarker candidates in clinical human urine samples associated with diabetic nephropathy. Leveraging plasmonic-based electrochemical impedance microscopy (P-EIM) imaging, we observed a remarkable charge sensitivity in monolayer WS2 single crystals...
April 16, 2024: Nano Letters