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https://www.readbyqxmd.com/read/28101180/acute-renal-injury-induced-by-valacyclovir-hydrochloride-a-case-report
#1
Yanning Zhang, Yuxi Cong, Yan Teng
Acyclovir has been a frequently used antiviral agent in the clinical treatment of leukemia, acute encephalitis, malignant tumor and herpes simplex. The adverse effects of this drug have been widely described in clinical practice. In the present study, a case of a 35-year-old female patient diagnosed with herpes simplex, who developed acute renal injury following treatment with valacyclovir hydrochloride, is described. Kidney biopsy, light microscopy and laboratory examination were performed, and all findings revealed the signs of evident vacuolar degeneration of capillary endothelial and renal tubular epithelial cells, erythrocyte aggregation in partial renal tubule and microvilli exfoliation from epithelial cells...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28101130/silica-titania-xerogel-doped-with-mo-p-heteropoly-compounds-for-solid-phase-spectrophotometric-determination-of-ascorbic-acid-in-fruit-juices-pharmaceuticals-and-synthetic-urine
#2
Maria A Morosanova, Elena I Morosanova
BACKGROUND: Ascorbic acid is one of the most important vitamins to monitor in dietary sources (juices and vitamins) and biological liquids. RESULTS: Silica and silica-titania xerogels doped with Mo,P-heteropoly compounds (HPC) have been synthesized varying titanium(IV) and HPC content in sol. Their surface area and porosity have been studied with nitrogen adsorption and scanning electron microscopy, their elemental composition has been studied with energy-dispersive X-ray analysis...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28100191/diagnostic-dilemma-of-pulmonary-tuberculosis-among-adults-with-severe-mental-illness-in-beijing-china
#3
Li Wang, Zhiguo Zhang, Qiuli Yan, Jie Lu, Baoyin Gao, Yanlin Zhao, Yu Pang
BACKGROUND: Although the prevalence of tuberculosis has decreased significantly over the past decades, the certain populations with mental illness are at increased risk for tuberculosis infection and transmission. However, no studies have examined the performance of different laboratory examination methods among people with severe mental illness in China. METHODS: In this study, we firstly performed a retrospective study to evaluate the feasibility of three routine laboratory methods, including sputum microscopy, solid culture and GeneXpert, to diagnose tuberculosis patients with mental illness...
January 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28097080/immunoglobulin-m-nephropathy-in-a-patient-with-wilson-s-disease
#4
Zain Ul Abideen, Zoya Sajjad, Asna Haroon Khan, Nadira Mamoon, Muhammad Bilal, Khaja Hameeduddin Mujtaba Quadri
Immunoglobulin M nephropathy (IgMN) is characterized by the deposition of immunoglobulin M in a dominant distribution in the renal glomeruli. Primary immunoglobulin M nephropathy is diagnosed after consistent light microscopy (LM), immunofluorescence (IF), electron microscopy (EM) results, and exclusion of known systemic disorders causing immunoglobulin M deposition in the glomeruli. The secondary disease has been reported with a few conditions though it has never been reported with any primary disease of the liver...
December 13, 2016: Curēus
https://www.readbyqxmd.com/read/28095801/providing-lipid-based-nutrient-supplement-during-pregnancy-does-not-reduce-the-risk-of-maternal-p-falciparum-parasitaemia-and-reproductive-tract-infections-a-randomised-controlled-trial
#5
Minyanga Nkhoma, Per Ashorn, Ulla Ashorn, Kathryn G Dewey, Austrida Gondwe, John Mbotwa, Stephen Rogerson, Steve M Taylor, Kenneth Maleta
BACKGROUND: Maternal infections are associated with maternal and foetal adverse outcomes. Nutrient supplementation during pregnancy may reduce the occurrence of infections by improving maternal immunity. We aimed to investigate the impact of small-quantity lipid-based nutrient supplement (SQ-LNS) on the occurrence of Plasmodium falciparum parasitaemia during pregnancy and trichomoniasis, vaginal candidiasis and urinary tract infection (UTI) after delivery. METHODS: Pregnant Malawian women enrolled in the iLiNS-DYAD trial receiving daily supplementation with SQ-LNS, multiple micronutrients (MMN) or iron & folic acid (IFA) from <20 gestation weeks (gw) were assessed for P...
January 17, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28094353/surfactant-free-synthesis-of-three-dimensional-nitrogen-doped-hierarchically-porous-carbon-and-its-application-as-an-electrode-modification-material-for-simultaneous-sensing-of-ascorbic-acid-dopamine-and-uric-acid
#6
Anaclet Nsabimana, Jianping Lai, Suping Li, Pan Hui, Zhongyuan Liu, Guobao Xu
Three-dimensional N-doped hierarchically porous carbon (3D NHPC) was synthesized successfully without using any surfactant or etching agent. This simple and effective synthesis method was accomplished by solvothermal synthesis followed by pyrolysis. The physical morphology and chemical composition of 3D NHPC were verified by scanning electron microscopy, nitrogen adsorption-desorption, and X-ray photoelectron spectroscopy. Its structural studies reveal that it exhibits a micro-mesoporous hierarchical structure and contains C, O and N atoms forming different functional groups...
January 17, 2017: Analyst
https://www.readbyqxmd.com/read/28063795/effect-of-new-tuberculosis-diagnostic-technologies-on-community-based-intensified-case-finding-a-multicentre-randomised-controlled-trial
#7
Gregory L Calligaro, Lynn S Zijenah, Jonathan G Peter, Grant Theron, Virginia Buser, Ruth McNerney, Wilbert Bara, Tsitsi Bandason, Ureshnie Govender, Michele Tomasicchio, Liezel Smith, Bongani M Mayosi, Keertan Dheda
BACKGROUND: Inadequate case detection results in high levels of undiagnosed tuberculosis in sub-Saharan Africa. Data for the effect of new diagnostic tools when used for community-based intensified case finding are not available, so we investigated whether the use of sputum Xpert-MTB/RIF and the Determine TB LAM urine test in two African communities could be effective. METHODS: In a pragmatic, randomised, parallel-group trial with individual randomisation stratified by country, we compared sputum Xpert-MTB/RIF, and if HIV-infected, the Determine TB LAM urine test (novel diagnostic group), with laboratory-based sputum smear microscopy (routine diagnostic group) for intensified case finding in communities with high tuberculosis and HIV prevalence in Cape Town, South Africa, and Harare, Zimbabwe...
January 4, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28057071/parasitic-infections-and-maternal-anaemia-among-expectant-mothers-in-the-dangme-east-district-of-ghana
#8
Samuel Crowther Kofi Tay, Emmanuel Agbeko Nani, Williams Walana
BACKGROUND: Parasitic infections are of public health concern globally, particular among at risk groups such as pregnant women in developing countries. The presence of these parasites during pregnancy potentiate adverse effects to both the mother and the unborn baby. This study sought to establish the prevalence of some parasitic agents among antenatal attendees in the Dangme East District of Ghana. A cross-sectional prospective study was conduct between April and July, 2012. Venous blood specimens were collected from each participant for haemoglobin estimation and malaria microscopy...
January 3, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28052781/inpatient-urine-cultures-are-frequently-performed-without-urinalysis-or-microscopy-findings-from-a-large-academic-medical-center
#9
Abigail L Carlson, Satish Munigala, Anthony J Russo, Kathleen M McMullen, Helen Wood, Ronald Jackups, David K Warren
OBJECTIVE To describe the frequency of urine cultures performed in inpatients without additional testing for pyuria DESIGN Retrospective cohort study SETTING A 1,250-bed academic tertiary referral center PATIENTS Hospitalized adults METHODS This study included urine cultures drawn on 4 medical and 2 surgical wards from 2009 to 2013 and in the medical and surgical intensive care units (ICUs) from 2012 to 2013. Patient and laboratory data were abstracted from the hospital's medical informatics database. We identified catheter-associated urinary tract infections (CAUTIs) in the ICUs by routine infection prevention surveillance...
January 5, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28052589/magnetic-iron-oxide-nanoparticles-grafted-n-isopropylacrylamide-chitosan-copolymer-for-the-extraction-and-determination-of-letrozole-in-human-biological-samples
#10
Mercede Khalaj Moazen, Homayon Ahmad Panahi
Magnetic iron oxide nanoparticles are used for the extraction of a drug from an aqueous solution. In the current study, the magnetic iron oxide nanoparticles were synthesized via a facile co-precipitation approach, and then modified by (3-mercaptopropyl)trimethoxysilane followed by grafting thermosensitive polymer N-isopropylacrylamide and biopolymer chitosan. Structure, morphology, size, thermal resistance, specific surface area and magnetic properties of the grafted nano-sorbent were characterized by using Fourier transform infrared spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, elemental analysis, thermogravimetric analysis, specific surface area analyzer Brunauer-Emmett-Teller and vibrating sample magnetometer techniques...
January 4, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28051762/impact-of-long-term-high-fat-diet-intake-gestational-protein-restricted-offspring-on-kidney-morphology-and-function
#11
V H G Rizzi, L D B Sene, C D B Fernandez, J A R Gontijo, P A Boer
Emerging evidence highlights the far-reaching consequences of high-fat diet (HFD) and obesity on kidney morphological and functional disorders. In the present study, we aim to evaluate the effects of early HFD intake on renal function and morphology in maternal protein-restricted offspring (LP). LP and normal protein-intake offspring (NP) were fed HFD (LPH and NPH, respectively) or standard rodent (LPN and NPN) diet from the 8th to 13th week of age. Blood pressure, kidney function, immunohistochemistry and scanning electron microscopy were analyzed...
February 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28043543/investigation-of-urine-lipoarabinomannan-in-human-immunodeficiency-virus-patients-with-or-without-coinfection-with-tuberculosis-in-iran
#12
Payam Tabarsi, Majid Marjani, Afshin Moniri, Parissa Farnia, Mehdi Kazempour Dizaji, John Garssen, Ian M Adcock, Esmaeil Mortaz
OBJECTIVE/BACKGROUND: Tuberculosis (TB) remains the leading cause of AIDS-related deaths among adults in countries with resource limitations. The emergence of the Xpert MTB/RIF rapid molecular assay and its subsequent World Health Organization endorsement in 2010 transformed the TB-diagnostic landscape. Xpert provided diagnostic accuracy that was far superior to that of the sputum-smear microscopy test previously used. The detection of mycobacterial lipoarabinomannan (LAM) antigen in urine has emerged as a potential point-of-care test for TB...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28035708/solid-phase-microextraction-of-methadone-in-urine-samples-by-electrochemically-co-deposited-sol-gel-cu-nanocomposite-fiber
#13
Sirwan Mohammadiazar, Fatemeh Hasanli, Mehdi Maham, Somayeh Payami Samarin
Electrochemically co-deposited sol-gel/Cu nanocomposites has been introduced as a novel, simple and single step technique for preparation of solid phase microextraction coating to extract methadone (MDN) (a synthetic opioid) in urine samples. The porous surface structure of the sol-gel/Cu nanocomposite coating was revealed by scanning electron microscopy (SEM). Direct immersion-solid phase microextraction (DI-SPME) followed by HPLC-UV determination was employed. The factors influencing the SPME procedure such as the salt content, desorption solvent type, pH and equilibration time were optimized...
December 30, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28033585/carbon-coated-magnetic-nanoparticles-as-a-novel-magnetic-solid-phase-extraction-adsorbent-for-simultaneous-extraction-of-methamphetamine-and-ephedrine-from-urine-samples
#14
Arezou Taghvimi, Hamed Hamishehkar
This paper develops a highly selective, specific and efficient method for simultaneous determination of ephedrine and methamphetamine by a new carbon coated magnetic nanoparticles (C/MNPs) as a magnetic solid phase extraction (MSPE) adsorbent in biological urine medium. The characterization of synthesized magnetic nano adsorbent was completely carried out by various characterization techniques like Fourier transform infrared (FT-IR) spectroscopy, powder x-ray diffraction (XRD), scanning electron microscopy (SEM) and vibrating sample magnetometer (VSM)...
January 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28031465/aggregation-of-full-length-immunoglobulin-light-chains-from-al-amyloidosis-patients-is-remodeled-by-epigallocatechin-3-gallate
#15
Kathrin Andrich, Ute Hegenbart, Christoph Kimmich, Niraja Kedia, H Robert Bergen, Stefan Schönland, Erich E Wanker, Jan Bieschke
Intervention into amyloid deposition with anti-amyloid agents like the polyphenol Epigallocatechin-3-gallate (EGCG) is emerging as an experimental secondary treatment strategy in systemic light chain amyloidosis (AL). In both AL and Multiple Myeloma (MM), soluble immunoglobulin light chains (LC) are produced by clonal plasma cells, but only in AL they form amyloid deposits in vivo. We investigated the amyloid formation of patient-derived LC and their susceptibility to EGCG in vitro to probe commonalities and systematic differences in their assembly mechanisms...
December 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28027887/adsorptive-anodic-stripping-differential-pulse-voltammetric-determination-of-cellcept-at-fe3o4-nanoparticles-decorated-multi-walled-carbon-nanotubes-modified-glassy-carbon-electrode
#16
Mohammad Bagher Gholivand, Mohammad Solgi
A simple and sensitive method based on adsorptive anodic stripping differential pulse voltammetry (AASDPV) for the determination of cellcept, using a magnetic Fe3O4 nanoparticles and functionalized (carboxylated) multi-walled carbon nanotubes modified glassy carbon electrode (f-MWCNs/Fe3O4/GCE) was developed. In phosphate buffer solution (pH = 5), the voltammogram of cellcept exhibited tow anodic peaks and the well-defined peak at about 0.611 V vs SCE was used for its monitoring. The modified electrode was characterized by different methods such as electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM) and cyclic voltammetry (CV)...
December 24, 2016: Analytical Biochemistry
https://www.readbyqxmd.com/read/28018704/synthesis-and-characterization-of-molecular-imprinting-polymer-microspheres-of-piperine-extraction-of-piperine-from-spiked-urine
#17
Rachel Marcella Roland, Showkat Ahmad Bhawani
Molecularly imprinted polymer (MIP) microspheres for Piperine were synthesized by precipitation polymerization with a noncovalent approach. In this research Piperine was used as a template, acrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and 2,2'-azobisisobutyronitrile (AIBN) as an initiator and acetonitrile as a solvent. The imprinted and nonimprinted polymer particles were characterized by using Fourier transform infrared spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM)...
2016: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28012848/detection-of-sessile-serrated-adenomas-in-proximal-colon-using-wide-field-fluorescence-endoscopy
#18
Bishnu P Joshi, Zhenzhen Dai, Zhenghong Gao, Jeong Hoon Lee, Navin Ghimire, Jing Chen, Anoop Prabhu, Erik J Wamsteker, Richard S Kwon, Grace H Elta, Elena M Stoffel, Asha Pant, Tonya Kaltenbach, Roy M Soetikno, Henry D Appelman, Rork Kuick, D Kim Turgeon, Thomas D Wang
BACKGROUND & AIMS: Many cancers in the proximal colon develop via from sessile serrated adenomas (SSAs), which have flat, subtle features that are difficult to detect with conventional white-light colonoscopy. Many SSA cells have the V600E mutation in BRAF. We investigated whether this feature could be used with imaging methods to detect SSAs in patients. METHODS: We used phage display to identify a peptide that binds specifically to SSAs, using subtractive hybridization with HT29 colorectal cancer cells containing the V600E mutation in BRAF and Hs738...
December 21, 2016: Gastroenterology
https://www.readbyqxmd.com/read/28004150/assessment-of-urinary-microparticles-in-normotensive-patients-with-type-1-diabetes
#19
Yuliya Lytvyn, Fengxia Xiao, Christopher R J Kennedy, Bruce A Perkins, Heather N Reich, James W Scholey, David Z Cherney, Dylan Burger
AIMS/HYPOTHESIS: Assessment of urinary extracellular vesicles including exosomes and microparticles (MPs) is an emerging approach for non-invasive detection of renal injury. We have previously reported that podocyte-derived MPs are increased in diabetic mice in advance of albuminuria. Here, we hypothesised that type 1 diabetes and acute hyperglycaemia would increase urinary podocyte MP levels in uncomplicated diabetes. METHODS: In this post hoc exploratory analysis, we examined archived urine samples from normoalbuminuric patients with uncomplicated type 1 diabetes studied under clamped euglycaemia and hyperglycaemia and compared with healthy controls...
December 21, 2016: Diabetologia
https://www.readbyqxmd.com/read/28000095/exosomes-from-ipscs-delivering-sirna-attenuate-intracellular-adhesion-molecule-1-expression-and-neutrophils-adhesion-in-pulmonary-microvascular-endothelial-cells
#20
Zhihai Ju, Jinhui Ma, Chen Wang, Jie Yu, Yeru Qiao, Feilong Hei
The pro-inflammatory activation of pulmonary microvascular endothelial cells resulting in continuous expression of cellular adhesion molecules, and subsequently recruiting primed neutrophils to form a firm neutrophils-endothelium (PMN-EC) adhesion, has been examined and found to play a vital role in acute lung injury (ALI). RNA interference (RNAi) is a cellular process through harnessing a natural pathway silencing target gene based on recognition and subsequent degradation of specific mRNA sequences. It opens a promising approach for precision medicine...
December 21, 2016: Inflammation
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