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Iron deficiency anemia

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https://www.readbyqxmd.com/read/28915649/digoxin-induced-anemia-among-patients-with-atrial-fibrillation-and-heart-failure-clinical-data-analysis-and-drug-gene-interaction-network
#1
Yubi Lin, Siqi He, Ruiling Feng, Zhe Xu, Wanqun Chen, Zifeng Huang, Yang Liu, Qianhuan Zhang, Bin Zhang, Kejian Wang, Shulin Wu
Digoxin is widely used to treat various heart conditions. In order to clarify the association between digoxin and anemia adverse reaction, we inspected case reports submitted to the FDA Adverse Event Reporting System (FAERS) between January 2004 and December 2015. These reports involved 75618 atrial fibrillation patients and 15699 heart failure patients. Compared to other therapies, digoxin treatment was significantly more likely to be concurrent with anemia adverse reaction among both atrial fibrillation patients (pooled OR = 1...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914813/lactoferrin-a-natural-glycoprotein-involved-in-iron-and-inflammatory-homeostasis
#2
REVIEW
Luigi Rosa, Antimo Cutone, Maria Stefania Lepanto, Rosalba Paesano, Piera Valenti
Human lactoferrin (hLf), an iron-binding multifunctional cationic glycoprotein secreted by exocrine glands and by neutrophils, is a key element of host defenses. HLf and bovine Lf (bLf), possessing high sequence homology and identical functions, inhibit bacterial growth and biofilm dependently from iron binding ability while, independently, bacterial adhesion to and the entry into cells. In infected/inflamed host cells, bLf exerts an anti-inflammatory activity against interleukin-6 (IL-6), thus up-regulating ferroportin (Fpn) and transferrin receptor 1 (TfR1) and down-regulating ferritin (Ftn), pivotal actors of iron and inflammatory homeostasis (IIH)...
September 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28911612/effects-of-carbonyl-iron-powder-on-iron-deficiency-anemia-and-its-subchronic-toxicity
#3
Qiaosha Zhu, Yang Qian, Ying Yang, Weifeng Wu, Jingli Xie, Dongzhi Wei
Carbonyl iron powder (CIP) has been used as a food additive or mineral supplement. However, the effects of CIP on iron deficiency anemia (IDA) and its subchronic toxicity have not been investigated. We found that oral administration of CIP at a dose of 2.96 mg/kg recovered the hemoglobin concentration of erythrocytes of IDA rats to the normal level after 8 days. The no observed adverse effect level of CIP in rats was considered to be > 200 mg/kg. The hematological and serum biochemical parameters of the rats did not differ significantly between the control and treated groups...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28901214/total-dose-iron-dextran-infusion-versus-oral-iron-for-treating-iron-deficiency-anemia-in-pregnant-women-a-randomized-controlled-trial
#4
A M Darwish, E E Khalifa, E Rashad, E Farghally
STUDY OBJECTIVE: To test safety, efficacy and cost-effectiveness of total dose infusion (TDI) of low molecular weight (LMW) iron dextran for treatment of iron deficiency anemia (IDA) during pregnancy in comparison to oral ferrous fumarate. DESIGN: Prospective interventional randomized controlled trial (RCT). Design classification. Canadian Task Force II3. SETTING: Antenatal clinic and causality unit of a tertiary care referral facility and University Hospital...
September 13, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28898272/iron-deficiency-was-not-the-major-cause-of-anemia-in-rural-women-of-reproductive-age-in-sidama-zone-southern-ethiopia-a-cross-sectional-study
#5
Tafere Gebreegziabher, Barbara J Stoecker
BACKGROUND: Anemia, which has many etiologies, is a moderate/severe public health problem in young children and women of reproductive age in many developing countries. The aim of this study was to investigate prevalence of iron deficiency, anemia, and iron deficiency anemia using multiple biomarkers and to evaluate their association with food insecurity and food consumption patterns in non-pregnant women from a rural area of southern Ethiopia. METHODS: A cross-sectional study was conducted in 202 rural women of reproductive age in southern Ethiopia...
2017: PloS One
https://www.readbyqxmd.com/read/28894708/hepatic-proteins-and-inflammatory-markers-in-rheumatoid-arthritis-patients
#6
Manel Ben-Hadj-Mohamed, Souhir Khelil, Mokhles Ben Dbibis, Latifa Khlifi, Hend Chahed, Salima Ferchichi, Elyes Bouajina, Abdelhédi Miled
BACKGROUND: Rheumatoid arthritis is an autoimmune inflammatory rheumatic disease that causes chronic synovial inflammation eventually leading to joint destruction and disability. The aim of this study was to determine the variations of hepatic proteins, myeloperoxidase, and iron in rheumatoid arthritis Tunisian patients and their implications in inflammation and in iron metabolism. METHODS: Overall, 172 patients from the Rheumatology Department of the University Hospital "Farhat Hached", Sousse-Tunisia between 2011 and 2012, with rheumatoid arthritis (97...
August 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28894019/iron-nicotianamine-transporters-are-required-for-proper-long-distance-iron-signaling
#7
Rakesh K Kumar, Heng-Hsuan Chu, Celina Abundis, Kenneth Vasques, David Chan-Rodriguez, Ju-Chen Chia, Rong Huang, Olena K Vatamaniuk, Elsbeth Lewis Walker
The mechanisms of root iron uptake and the transcriptional networks that control root level regulation of iron uptake have been well studied, but the mechanisms by which shoots signal iron status to the roots remain opaque. Here we characterize a double mutant, ysl1ysl3, which has lost the ability to properly regulate iron-deficiency-influenced gene expression in both roots and shoots. In spite of markedly low tissue levels of iron, the double mutant does not up- and down-regulate iron deficiency induced and repressed genes...
September 11, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28885736/prevalence-and-prognostic-impact-of-anemia-and-iron-deficiency-in-patients-hospitalized-in-an-internal-medicine-ward-the-pro-iron-study
#8
Cândida Fonseca, Manuel Araújo, Patrícia Moniz, Filipa Marques, Inês Araújo, Luís Costa, Joana Rodrigues, Luciana Frade, Arturo Botella, Susana Jesus, Ana Leitão, Luís Campos
To assess prevalence, predictive factors, and prognostic impact on in-hospital mortality of anemia, iron deficiency anemia (IDA), iron deficiency with or without anemia (ID), and iron deficiency without anemia (IDWA) in patients admitted to an internal medicine ward METHODS: This one-year prospective study collected data on demographics, medical history, and blood tests in 771 consecutive patients on admission RESULTS: Most patients were ≥65 years old (80%), and had hypertension (63%), moderate chronic kidney disease (CKD) (43%), and heart failure (41%)...
September 8, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28882616/screening-of-inflammatory-bowel-disease-and-spondyloarthritis-for-referring-patients-between-rheumatology-and-gastroenterology
#9
Jesús Sanz Sanz, Xavier Juanola Roura, Daniel Seoane-Mato, Miguel Montoro, Fernando Gomollón
OBJECTIVE: To define clinical screening criteria for spondyloarthritis (SpA) in patients with inflammatory bowel disease (IBD) and vice versa, which can be used as a reference for referring them to the rheumatology or gastroenterology service. METHOD: Systematic literature review and a two-round Delphi method. The scientific committee and the expert panel were comprised of 2 rheumatologists and 2 gastroenterologists, and 7 rheumatologists and 7 gastroenterologists, respectively...
September 4, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28879221/delusional-parasitosis-secondary-to-severe-iron-deficiency-anemia
#10
Sahil Sekhon, Caleb Jeon, Mio Nakamura, John Koo
No abstract text is available yet for this article.
September 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28878525/association-of-three-h-hookworm-hemosuccus-pancreaticus-and-hypertension-portal-in-a-patient-with-melena
#11
Pratibha Kale, Monalisa Sahu, Nishant Verma, Bijay Ranjan Mirdha
Hookworm infestations, endemic in India, are a common cause of iron deficiency anemia. Hemosuccus pancreaticus, a rare clinical condition, is due to passage of blood into the pancreatic duct possibly through a route between an aneurysm of an artery close to the pancreas and/or pancreatic duct, leading to gastrointestinal (GI) bleeding. Portal hypertensive upper GI bleed is also known since long. We report a case of a 38-year-old male with a history of alcoholism who was being investigated for GI bleeding who had concomitant hookworm infestation, hemosuccus pancreaticus as well as portal hypertension...
July 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/28877570/hookworm-infection-a-neglected-cause-of-overt-obscure-gastrointestinal-bleeding
#12
Kun-Yan Wei, Qiong Yan, Bo Tang, Shi-Ming Yang, Peng-Bing Zhang, Ming-Ming Deng, Mu-Han Lü
Hookworm infections are widely prevalent in tropical and subtropical areas, especially in low income regions. In the body, hookworms parasitize the proximal small intestine, leading to chronic intestinal hemorrhage and iron deficiency anemia. Occasionally, hookworms can cause overt gastrointestinal bleeding, but this is often ignored in heavily burdened individuals from endemic infectious areas. A total of 424 patients with overt obscure gastrointestinal bleeding were diagnosed by numerous blood tests or stool examinations as well as esophagogastroduodenoscopy, colonoscopy, capsule endoscopy or double-balloon enteroscopy...
August 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28876332/zinc-and-multivitamin-supplementation-have-contrasting-effects-on-infant-iron-status-a-randomized-double-blind-placebo-controlled-clinical-trial
#13
R C Carter, R Kupka, K Manji, C M McDonald, S Aboud, J G Erhardt, K Gosselin, R Kisenge, E Liu, W Fawzi, C P Duggan
BACKGROUND/OBJECTIVES: Zinc (Zn) supplementation adversely affects iron status in animal and adult human studies, but few trials have included young infants. The objective of this study was to determine the effects of Zn and multivitamin (MV) supplementation on infant hematologic and iron status. SUBJECTS/METHODS: In a double-blind RCT, Tanzanian infants were randomized to daily, oral Zn, MV, Zn and MV or placebo treatment arms at the age of 6 weeks of life. Hemoglobin concentration (Hb) and red blood cell indices were measured at baseline and at 6, 12 and 18 months of age...
September 6, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28875005/iron-profile-and-inflammatory-status-of-overweight-and-obese-women-in-sari-north-of-iran
#14
Ramin Shekarriz, Mohammad Mehdi Vaziri
Background: It has been suggested that inflammatory state due to obesity can lead to alteration in iron metabolism. Women in reproductive age are at higher risk of iron deficiency. In this study, we aimed to evaluate inflammatory status and iron markers in young overweight and obese women. Subjects and Methods: In this study, 120 young and healthy women with a BMI ≥ 25 kg/m2 were enrolled. Biochemical data including iron profile and inflammatory markers were analyzed using mean ± standard deviation or median (interquartile range) and multivariate multiple regression model via MANOVA...
April 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28874768/a-new-red-cell-index-and-portable-rbc-analyzer-for-screening-of-iron-deficiency-and-thalassemia-minor-in-a-chinese-population
#15
Lieshu Tong, Josef Kauer, Sebastian Wachsmann-Hogiu, Kaiqin Chu, Hu Dou, Zachary J Smith
Anemia is a widespread public health problem with 1/4 ~1/3 of the world's population being affected. In Southeast Asia, Thalassemia trait (TT) and iron deficiency anemia (IDA) are the two most common anemia types and can have a serious impact on quality of life. IDA patients can be treated with iron supplementation, yet TT patients have diminished capacity to process iron. Therefore, distinguishing between types of anemia is essential for effective diagnosis and treatment. Here, we present two advances towards low-cost screening for anemia...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28872486/comparison-of-different-iron-preparations-in-the-prophylaxis-of-iron-deficiency-anemia
#16
Ali Aydin, Emel Gur, Tugba Erener-Ercan, Gunay Can, Ahmet Arvas
We compared the efficacy of ferrous sulfate (divalent) and ferric polymaltose (trivalent) compounds for the prophylaxis of iron-deficiency anemia (IDA). Study infants included exclusively breast milk-fed term infants. Subjects were divided randomly into 2 groups at 4 months of age and group 1 (n=56) received divalent and group 2 (n=56) received trivalent iron (Fe) preparation at a dose of 2 mg/kg/d for 5 months. At 9 months of age, after a 5-month prophylaxis, a significant increase was observed in hemoglobin (Hb), hematocrit, serum Fe levels, and transferrin saturation in both groups...
September 1, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28869958/management-of-nephrotic-syndrome-a-case-report-from-lao-pdr
#17
Phanekham Souvannamethy
We report the case of a 23-year-old woman with a 2-week history of swelling around the eyes and both legs, and generalized body swelling. She had a history of chronic constipation and poor diet but no fever, recent illnesses, or hematuria. Examination revealed bilateral pedal edema and mild ascites. Laboratory investigations showed low hemoglobin 79 g/L, low mean corpuscular volume 53 fL, thrombocytosis 973 × 109/L, and marked hypochromia and microcytosis, with low iron and ferritin. She had hypoalbuminemia and reduced serum protein (albumin 1...
2017: Blood Purification
https://www.readbyqxmd.com/read/28864256/pica-is-prevalent-and-strongly-associated-with-iron-deficiency-among-hispanic-pregnant-women-living-in-the-united-states
#18
Aditi Roy, Elena Fuentes-Afflick, Lia C H Fernald, Sera L Young
INTRODUCTION: Anecdotal evidence suggests that pica occurs among Hispanic women in the United States, especially during pregnancy. However, the prevalence and socio-demographic and biological factors associated with pica in this population have not been adequately identified. METHODS: Trained, bilingual study personnel conducted structured interviews at public health clinics in Salinas Valley, California with 187 pregnant Hispanic women in their 2nd or 3rd trimesters of pregnancy...
August 31, 2017: Appetite
https://www.readbyqxmd.com/read/28854239/helicobacter-pylori-saba-gene-is-associated-with-iron-deficiency-anemia-in-childhood-and-adolescence
#19
Seiichi Kato, Takako Osaki, Shigeru Kamiya, Xue-Song Zhang, Martin J Blaser
BACKGROUND: Gastric Helicobacter pylori colonization leads to iron deficiency anemia (IDA), especially in children and adolescents. However the pathogenesis is poorly understood. OBJECTIVE: We sought to identify specific H. pylori genes involved in IDA development, by comparing bacterial genome-wide expression profiling in patients affected or not. METHODS: H. pylori were isolated from four children with IDA and four from matched controls without IDA...
2017: PloS One
https://www.readbyqxmd.com/read/28853335/correction-to-carvalho-et-al-prevalence-of-iron-deficiency-anemia-and-iron-deficiency-in-a-pediatric-population-with-inflammatory-bowel-disease
#20
(no author information available yet)
No abstract text is available yet for this article.
October 2017: Scandinavian Journal of Gastroenterology
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