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https://www.readbyqxmd.com/read/29790301/identification-of-eight-new-mhc-dpb1-alleles-in-the-tibetan-macaques-macaca-thibetana
#1
Y F Yao, Y Y Zhou, Y Qi, Q Zhao, H L Xu
We report here the identification of eight new Math-DPB1 alleles in the Tibetan macaques. This article is protected by copyright. All rights reserved.
May 22, 2018: HLA
https://www.readbyqxmd.com/read/29790270/metabolomics-reveals-the-key-role-of-oxygen-metabolism-in-the-heat-susceptibility-of-an-alpine-dwelling-ghost-moth-thitarodes-xiaojinensis-lepidoptera-hepialidae
#2
Wei Zhu, Qian Meng, Huan Zhang, Meng-Long Wang, Xuan Li, Hong-Tuo Wang, Gui-Ling Zhou, Lin Miao, Qi-Lian Qin, Ji-Hong Zhang
Ghost moths inhabiting the alpine meadows of the Tibetan Plateau are cold-adapted stenothermal organisms that are susceptible to heat (dead within 7 days of 27 °C exposure). Exploring the metabolic basis of their heat susceptibility would extend our understanding of the thermal biology of alpine dwelling invertebrates. Here, gas chromatography-mass spectrometry-based metabolomics was combined with physiological and transcriptional approaches to determine the metabolic mechanisms of heat susceptibility in Thitarodes xiaojinensis larvae...
May 23, 2018: Insect Science
https://www.readbyqxmd.com/read/29789833/zinc-catalyzed-reaction-of-isoxazoles-with-thioynol-ethers-involving-an-unprecedented-1-2-sulfur-migration
#3
Xin-Qi Zhu, Qing Sun, Zhi-Xin Zhang, Bo Zhou, Pei-Xi Xie, Wen-Bo Shen, Xin Lu, Jin-Mei Zhou, Long-Wu Ye
A novel zinc-catalyzed reaction of isoxazoles with thioynol ethers involving an unprecedented 1,2-sulfur migration has been developed, which represents the first example of a non-noble metal-catalyzed reaction between isoxazoles and alkynes. This method allows the facile and atom-economical synthesis of a range of valuable β-keto enamides. Moreover, the computational study provides further evidence for the feasibility of the proposed reaction mechanism.
May 23, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29789631/systematic-evaluation-of-a-171-yb-optical-clock-by-synchronous-comparison-between-two-lattice-systems
#4
Qi Gao, Min Zhou, Chengyin Han, Shangyan Li, Shuang Zhang, Yuan Yao, Bo Li, Hao Qiao, Di Ai, Ge Lou, Mengya Zhang, Yanyi Jiang, Zhiyi Bi, Longsheng Ma, Xinye Xu
Optical clocks are the most precise measurement devices. Here we experimentally characterize one such clock based on the 1 S0 -3 P0 transition of neutral 171 Yb atoms confined in an optical lattice. Given that the systematic evaluation using an interleaved stabilization scheme is unable to avoid noise from the clock laser, synchronous comparisons against a second 171 Yb lattice system were implemented to accelerate the evaluation. The fractional instability of one clock falls below 4 × 10-17 after an averaging over a time of 5,000 seconds...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789567/precise-control-of-scramble-in-synthetic-haploid-and-diploid-yeast
#5
Bin Jia, Yi Wu, Bing-Zhi Li, Leslie A Mitchell, Hong Liu, Shuo Pan, Juan Wang, Hao-Ran Zhang, Nan Jia, Bo Li, Michael Shen, Ze-Xiong Xie, Duo Liu, Ying-Xiu Cao, Xia Li, Xiao Zhou, Hao Qi, Jef D Boeke, Ying-Jin Yuan
Compatibility between host cells and heterologous pathways is a challenge for constructing organisms with high productivity or gain of function. Designer yeast cells incorporating the Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution (SCRaMbLE) system provide a platform for generating genotype diversity. Here we construct a genetic AND gate to enable precise control of the SCRaMbLE method to generate synthetic haploid and diploid yeast with desired phenotypes. The yield of carotenoids is increased to 1...
May 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29787749/epidermal-hmgb1-activates-dermal-fibroblasts-and-causes-hypertrophic-scar-formation-in-reduced-hydration
#6
Jingling Zhao, Jianxing Yu, Yingbin Xu, Lei Chen, Fei Zhou, Qiyi Zhai, Jun Wu, Bin Shu, Shaohai Qi
High-mobility group box 1 (HMGB1) protein is a multifunctional cytokine involved in inflammatory reactions and is known to play a key role in tissue repair and fibrosis. However, the function of HMGB1 in fibrotic skin diseases, such as hypertrophic scar formation, remains unclear. In this study, HMGB1 was detected in the nuclei of epidermal cells in normal skin and had accumulated in the cytoplasm in hypertrophic scars. By establishing a keratinocyte-fibroblast co-culture and conditional medium treatment models, we found that a reduced hydration condition increased the expression and secretion of HMGB1 in keratinocytes, subsequently activating dermal fibroblasts...
May 19, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29784962/carrier-thermometry-of-cold-ytterbium-atoms-in-an-optical-lattice-clock
#7
Chengyin Han, Min Zhou, Xiaohang Zhang, Qi Gao, Yilin Xu, Shangyan Li, Shuang Zhang, Xinye Xu
The ultracold atomic gas serving as the quantum reference is a key part of an optical lattice clock, and the temperature of atoms in the optical lattice affects the uncertainty and instability of the optical lattice clocks. Since the carrier spectrum of the clock transition in the lattices reflects the thermal dynamics of cold atoms, the temperature of atoms can be extracted from the carrier spectrum in a non-magic wavelength lattice of ytterbium optical clocks. Furthermore, the temperatures obtained from the carrier spectra are in good agreement with the results obtained by the time-of-flight method and thermometry based on the sideband spectrum...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784381/synthesis-of-a-selective-ratiometric-fluorescent-probe-based-on-naphthalimide-and-its-application-in-human-cytochrome-p450-1a
#8
Xiuxuan Zhang, Yan Zhou, Xiaofei Gu, Yu Cheng, Manxin Hong, Liqiang Yan, Fulong Ma, Zhengjian Qi
Cytochrome P450s have brought considerable attention to researchers for their significant correlations with metabolic behaviors of procarcinogenic chemicals. To better understand the roles of CYP1A in biological and physiological systems, we developed a novel ratiometric fluorescence probe N-((2-hydroxyl ethoxy) ethyl)- 4-methoxy-1, 8-naphthalimide (NEMN) allowing for selectively and sensitively monitoring the target enzymes under physiological conditions and living cells. The probe was designed based on substrate predilection of CYP1A and its outstanding O-dealkylation capacity, and 1, 8-naphthalimide was chosen as fluorophore on account of its desirable photophysical properties...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29783952/differences-between-fast-and-slow-muscles-in-scallops-revealed-through-proteomics-and-transcriptomics
#9
Xiujun Sun, Zhihong Liu, Biao Wu, Liqing Zhou, Qi Wang, Wei Wu, Aiguo Yang
BACKGROUND: Scallops possess striated and catch adductor muscles, which have different structure and contractile properties. The striated muscle contracts very quickly for swimming, whereas the smooth catch muscle can keep the shells closed for long periods with little expenditure of energy. In this study, we performed proteomic and transcriptomic analyses of differences between the striated (fast) and catch (slow) adductor muscles in Yesso scallop Patinopecten yessoensis. RESULTS: Transcriptomic analysis reveals 1316 upregulated and 8239 downregulated genes in slow compared to fast adductor muscle...
May 22, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29781268/iterative-synthesis-of-polydeoxypropionates-based-on-iridium-catalyzed-asymmetric-hydrogenation-of-%C3%AE-substituted-acrylic-acids
#10
Wen Che, Danyang C Wen, Shou-Fei Zhu, Qi-Lin Zhou
A novel iterative protocol for the synthesis of polydeoxypropionates was developed based on iridium-catalyzed asymmetric hydrogenation of α-substituted acrylic acids. The catalyst loading can be as low as 0.01 mol %, and the overall yield for one iterative cycle is >76%. The reaction conditions are mild, and no organometallic reagents or chromatography steps are required. Using this protocol, (+)-phthioceranic acid and the polydeoxypropionate motifs of ionomycin and borrelidin were synthesized in high yield...
May 21, 2018: Organic Letters
https://www.readbyqxmd.com/read/29780329/involvement-of-met-and-kr-h1-in-jh-mediated-reproduction-of-female-bactrocera-dorsalis-hendel
#11
Yong Yue, Rui-Lin Yang, Wei-Ping Wang, Qi-Hao Zhou, Er-Hu Chen, Guo-Rui Yuan, Jin-Jun Wang, Wei Dou
Juvenile hormone (JH) prevents metamorphosis during insect larval stages and promotes adult reproductive processes. Krüppel-homolog 1 (Kr-h1), a zinc finger transcription factor assumed to be induced by JH via the JH receptor methoprene-tolerant (Met), mediates the antimetamorphic effect of JH in insects, but its function in JH-mediated reproductive processes has not been fully explored. In this study, Met and Kr-h1 involved in the JH signaling pathway were first cloned and identified from the oriental fruit fly, Bactrocera dorsalis , an important pest infesting fruit and vegetables worldwide...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29776005/flexible-and-hierarchical-metal-organic-framework-composites-for-high-performance-catalysis
#12
Ning Huang, Hannah Drake, Jialuo Li, Jiangdong Pang, Ying Wang, Shuai Yuan, Qi Wang, Peiyu Cai, Junsheng Qin, Hong-Cai Zhou
The development of new types of porous composite materials is of great significance owing to their potentially improved performance over those of individual components and extensive applications in separation, energy storage, and heterogeneous catalysis. In this work, we integrated mesoporous metal-organic frameworks (MOFs) with macroporous melamine foam (MF) using a one-pot process, generating a series of MOF/MF composite materials with preserved crystallinity, hierarchical porosity, and increased stability over that of melamine foam...
May 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29775753/long-non-coding-rna-biomarker-for-human-laryngeal-squamous-cell-carcinoma-prognosis
#13
Jingjing Chen, Zhisen Shen, Hongxia Deng, Wei Zhou, Qi Liao, Ying Mu
Long non-coding RNAs (lncRNA) were discovered in tumors. The regulation of lncRNA in human laryngeal squamous cell carcinoma (LSCC) remains incomplete. Uncovering the potential of lncRNA to stratify the prognosis of LSCC and streamline the vast amount of clinical information will affect medical interventions. The surgical resected LSCC tissues, adjacent non-cancerous tissues (ANCT) and lymph node metastatic tissue (LNM) were collected from 76 patients for lncRNA AC008440.10 expression assay. The stages of LSCC and LNM were classified accordingly...
May 15, 2018: Gene
https://www.readbyqxmd.com/read/29774833/pathogenic-leptospira-species-in-insectivorous-bats-china-2015
#14
Hui-Ju Han, Hong-Ling Wen, Jian-Wei Liu, Xiang-Rong Qin, Min Zhao, Li-Jun Wang, Li-Mei Luo, Chuan-Min Zhou, Ye-Lei Zhu, Rui Qi, Wen-Qian Li, Hao Yu, Xue-Jie Yu
PCR amplification of the rrs2 gene indicated that 50% (62/124) of insectivorous bats from eastern China were infected with Leptospira borgpetersenii, L. kirschneri, and several potentially new Leptospira species. Multilocus sequence typing defined 3 novel sequence types in L. kirschneri, suggesting that bats are major carriers of Leptospira.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29774752/effects-of-ethanol-on-the-anticancer-function-of-doxorubicin-in-jj012-cells
#15
Hui Huang, Yanze Li, Mingjuan Wu, Jing Luo, Junhui Nie, Baoyu Hou, Qi He, Yan Diao, Lin Qi, Yuanyuan Zhao, Ying Liu, Dan Yang, Lingyun Zhou
AIM: Chondrosarcoma is difficult to treat because of resistance to conventional chemotherapy and radiotherapy. This study evaluated the effects of ethanol in combination with doxorubicin in chondrosarcoma cells. MATERIALS & METHODS: JJ012, was treated with doxorubicin alone or in combination with ethanol. Effects on cellular proliferation, migration, invasion, apoptosis, and the cell cycle were evaluated. RESULTS: Treatment of JJ012 cells with 100 mM ethanol and doxorubicin resulted in reduced cell growth, invasion, and migration...
May 18, 2018: Future Oncology
https://www.readbyqxmd.com/read/29774101/qilin-pills-alleviate-oligoasthenospermia-by-inhibiting-bax-caspase-9-apoptosis-pathway-in-the-testes-of-model-rats
#16
Kaishu Zhang, Zhengyan Ge, Longlong Fu, Qi An, Fang Zhou, Ying Guo, Xiaowei Wang, Wenhong Lu, Xiaowei Liang, Shusong Wang, Xuejun Shang, Yiqun Gu
At present, the treatment of oligoasthenospermia with western medicine is ineffective. Qilin pill (QLP) is a Chinese traditional medicine for treating male infertility. Recent multicenter clinical studies in China reported that QLPs markedly improved sperm quality. However, the mechanism of action of QLPs on oligoasthenospermia remains unknown. In this study, we investigated the mechanistic basis for improvement of semen parameters and reversal of testis damage by QLPs in a rat model of oligoasthenospermia induced by treatment with tripterygium glycosides (TGs) (40 mg/kg) once daily for 4 weeks...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29773009/cloning-and-characterization-of-promoters-of-the-fungal-immunomodulatory-protein-genes-from-ganoderma-spp-agaricomycetes-and-their-response-to-methyl-jasmonate-and-salicylic-acid
#17
Qi-Zhang Li, Yu-Zhou Chang, Kai-Qi Su, Xiao-Lei Wang, Xiao-Hui Bai, Xuan-Wei Zhou
Ganoderma mushrooms for medicinal use contain various bioactive compounds, but the genetic elements available for these medicinal mushrooms are still limited. In this study we cloned and analyzed the promoters of fungal immunomodulatory protein (FIP) genes from G. lucidum and G. atrum. FIP gene expression was induced by different concentrations of methyl jasmonate (MeJA) and salicylic acid (SA), and messenger RNA expression was detected by quantitative reverse-transcription polymerase chain reaction. The results provided 5' upstream sequences of FIP genes from G...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29772494/effects-of-ceftriaxone-induced-intestinal-dysbacteriosis-on-regulatory-t-cells-validated-by-anaphylactic-mice
#18
Xia Luo, Zengfeng Pan, Shuang Luo, Qi Liu, Shaowei Huang, Guanghua Yang, Feifei Nong, Yajun Fu, Xiangliang Deng, Lian Zhou
Both probiotics and pathogens in the human gut express pathogen-associated molecular patterns (PAMPs) and die with the release of endotoxin and bacterial DNA, which can stimulate our immune system and cause immune reaction. However, it's interesting and fascinating to address why the normal intestinal flora will not generate immunological rejection like the pathogen does. By investigating the changes in cells and molecules relevant to immune tolerance in mice with ceftriaxone-induced dysbacteriosis, our study discovered that both the Evenness indexes and Shannon Wiener index of intestinal flora showed a decrease in dysbacteriosis mice...
May 14, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29772493/tissue-physiological-metabolic-adaptability-in-young-and-old-leaves-of-reed-phragmites-communis-in-songnen-grassland
#19
Rui Guo, Zhenzi Bai, Ji Zhou, XiuLi Zhong, FengXue Gu, Qi Liu, HaoRu Li
Common reed (Phragmites communis) is widely distributed as the dominant plant species in the Songnen Plain of China. The aim of this study was to investigate different physiological adaptive mechanisms to salinity tolerance between young and old leaves. The profiles of 68 metabolites were measured and studied in reed leaves by gas chromatography-mass spectrometer. The nitrogen, carbon, and pigment contents showed stronger growth inhibition for older leaves with salinity stress. In young leaves, high K+ contents not only promoted cell growth, but also prevented influx of superfluous Na+ ions in cells; the Ca2+ accumulation in old leaves implied that Ca2+ triggered the SOS-Na+ exclusion system and reduced Na+ toxicity...
May 9, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29770798/combined-treatment-with-apatinib-and-docetaxel-in-a549-xenograft-mice-and-its-cellular-pharmacokinetic-basis
#20
Si-Qi Feng, Guang-Ji Wang, Jing-Wei Zhang, Yuan Xie, Run-Bin Sun, Fei Fei, Jing-Qiu Huang, Ying Wang, Ji-Ye Aa, Fang Zhou
Apatinib, a small-molecule inhibitor of VEGFR-2, has attracted much attention due to its encouraging anticancer activity in third-line clinical treatment for many malignancies, including non-small cell lung cancer (NSCLC). Its usage in second-line therapy with chemotherapeutic drugs is still under exploration. In this study we investigated the antitumor effect of apatinib combined with docetaxel against NSCLC and its cellular pharmacokinetic basis. A549 xenograft nude mice were treated with apatinib (100 mg/kg every day for 20 days) combined with docetaxel (8 mg/kg, ip, every four days for 5 times)...
May 17, 2018: Acta Pharmacologica Sinica
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