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https://www.readbyqxmd.com/read/28650109/inducible-activation-of-fgfr2-in-adult-mice-promotes-bone-formation-after-bone-marrow-ablation
#1
Wei Xu, Fengtao Luo, Quan Wang, Qiaoyan Tan, Junlan Huang, Siru Zhou, Zuqiang Wang, Xianding Sun, Liang Kuang, Min Jin, Nan Su, Wanling Jiang, Liang Chen, Huabing Qi, Ying Zhu, Bo Chen, Hangang Chen, Shuai Chen, Yu Gao, Xiaoling Xu, Chuxia Deng, Lin Chen, Yangli Xie, Xiaolan Du
Apert syndrome is one of the most severe craniosynostoses, resulting from gain-of-function mutations in fibroblast growth factor receptor 2 (FGFR2). Previous studies have shown that gain-of-function mutations of FGFR2 (S252W or P253R) cause skull malformation of human Apert syndrome by affecting both chondrogenesis and osteogenesis, underscoring the key role of FGFR2 in bone development. However, the effects of FGFR2 on bone formation at the adult stage have not been fully investigated. To investigate the role of FGFR2 in bone formation, we generated mice with tamoxifen-inducible expression of mutant FGFR2 (P253R) at the adult stage...
June 26, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28649016/epileptic-seizure-detection-based-on-imbalanced-classification-and-wavelet-packet-transform
#2
Qi Yuan, Weidong Zhou, Liren Zhang, Fan Zhang, Fangzhou Xu, Yan Leng, Dongmei Wei, Meina Chen
PURPOSE: Automatic seizure detection is significant for the diagnosis of epilepsy and the reduction of massive workload for reviewing continuous EEG recordings. METHODS: Compared with the long non-seizure periods, the durations of the seizure events are much shorter in the continuous EEG recordings. So the seizure detection task can be regarded as an imbalanced classification problem. In this paper, a novel method based on the weighted extreme learning machine (ELM) is proposed for seizure detection with imbalanced EEG data distribution...
June 8, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28647369/synthesis-of-cytochrome-c-oxidase-1-sco1-inhibits-insulin-sensitivity-by-decreasing-copper-levels-in-adipocytes
#3
Xiang-Bo Wei, Liang Guo, Yang Liu, Shui-Rong Zhou, Yuan Liu, Xin Dou, Shao-Yue Du, Meng Ding, Wan-Qiu Peng, Shu-Wen Qian, Hai-Yan Huang, Qi-Qun Tang
Dysregulation of insulin signaling leads to type 2 diabetes mellitus (T2DM) and other metabolic disorders. Obesity is an important contributor to insulin resistance, and although the understanding of this relationship has improved in recent years, the mechanism of obesity-induced insulin resistance is not completely understood. Disorders of copper metabolism tend to accompany the development of obesity, which increases the risk of insulin resistance. Synthesis of cytochrome c oxidase 1 (SCO1) functions in the assembly of cytochrome c oxidase (COX) and cellular copper homeostasis...
June 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28647185/relationship-between-catecholamine-level-and-gene-polymorphism-of-%C3%AE-1-adrenergic-receptor-g1165c-in-children-with-ev71-infection-in-hand-foot-and-mouth-disease
#4
Zhi-Xian Lei, Bang-Tao Li, Hong-Ai Li, Xiao-Ming Li, Man-Fang Xie, Ting Huang, Qi Wang, Ya-Zhou Wang, Qiu-Yu Lin, Li-Rong Zhou, Nai-Chao Feng, Xin Li, Dao-Mou Zhu, Yuan-Ping Hai, Lan Cui, Ya-Qin Zhang, Zhi-Wen Liu, Shou-Ye Wu, Yong-Zhao Chen, Ke-Qing Zhu, Xiao-Jie He, Wei Xiang
OBJECTIVE: To investigate the relationship between the levels of plasma adrenaline and norepinephrine and gene polymorphism of β1 adrenergic receptor G1165C in children with enterovirus 71 (EV71) infection in hand foot and mouth disease (HFMD). METHODS: The polymerase chain reaction (PCR) was used to detect the expression of gene polymorphism of β1 adrenergic receptor G1165C in vitro. The levels of plasma adrenaline and norepinephrine were measured by enzyme-linked immunosorbent assay (ELISA)...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28647182/preoperative-application-of-combination-of-portal-venous-injection-of-donor-spleen-cells-and-intraperitoneal-injection-of-rapamycin-prolongs-the-survival-of-cardiac-allografts-in-mice
#5
Wen-Lin Gong, Chuang Sha, Gang Du, Zhong-Gui Shan, Zhong-Quan Qi, Su-Fang Zhou, Nuo Yang, Yong-Xiang Zhao
OBJECTIVE: To investigate the effects of preoperative portal venous injection of donor spleen cells (PVIDSC) and intraperitoneal injection of rapamycin in the acute rejection of cardiac allograft in mice and the underlying mechanisms. METHODS: Homogenous female B6 mice and BALB/c mice were used as recipients and donors of heart transplantation. These mice were randomly divided into different groups and received PVIDSC alone, rapamycin alone, or PVIDSC and rapamycin combined therapy...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28644250/cholesterol-levels-and-hemorrhagic-stroke-risk-in-east-asian-versus-non-east-asian-populations-a-systematic-review-and-meta-analysis
#6
Liang Xie, Wei Wu, Jin Chen, Jianglong Tu, Jun Zhou, Xueliang Qi, Xiaoping Yin
BACKGROUND: The aim of this work was to evaluate the relationships between cholesterol levels and risk of hemorrhagic stroke [including intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH)] in East Asian versus non-East Asian populations. MATERIALS AND METHODS: Relevant prospective studies were identified from systematic searches of PubMed and EMBASE. A random-effects model was used to calculate summary relative risks (RRs) and 95% confidence intervals (CIs) that were used to compare the relationships between cholesterol levels and risk of hemorrhagic stroke in East Asian versus non-East Asian populations...
July 2017: Neurologist
https://www.readbyqxmd.com/read/28644234/efficacy-of-sodium-hyaluronate-in-murine-diabetic-ocular-surface-diseases
#7
Guohu Di, Xia Qi, Xiaowen Zhao, Songmei Zhang, Qingjun Zhou
PURPOSE: To evaluate the efficacy of sodium hyaluronate (HA) eye drops for the treatment of diabetic ocular surface diseases in mice. METHODS: Male 6- to 8-week-old C57BL/6 mice underwent induction of type 1 diabetes with intraperitoneal injections of streptozotocin, with normal mice as the control. Topical 0.3% HA, 0.1% HA, 0.4% polyethylene glycol eye drops, and normal saline were administered to diabetic mice with an intact or debrided corneal epithelium. Normal saline was applied in the controls...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28643502/the-pathogenesis-and-potential-therapeutic-method-of-idiopathic-thrombocytopenic-purpura
#8
Xiaohong Zhao, Xiaomei Qi, Chen Wang, Zhonghao Zhou, Haiwu Cao, Pin Wu, Linghao Li, Shiyun Lu, Zhi Wang
BACKGROUND: This study sought to clarify the pathogenesis of idiopathic thrombocytopenic purpura(ITP) and make preliminary investigations regarding a therapeutic method. METHODS: ELISA was used to establish and analyze the standard curve for interferon (IFN)-γ, interleukin (IL)-4, and IL-17 in order to determine a measurement method for these cytokines. Subsequently, cellular levels of IFN-γ, IL-4, and IL-17 in the peripheral blood of patients in the treatment group (traditional Chinese medicine) was compared with those in the control group (Western-style care)...
June 21, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28643325/surface-expression-of-anti-cd3scfv-stimulates-locoregional-immunotherapy-against-hepatocellular-carcinoma-depending-on-the-e1a-engineered-human-umbilical-cord-mesenchymal-stem-cells
#9
Qing Zhang, Xiang-Fei Yuan, Yang Lu, Zhen-Zhen Li, Shi-Qi Bao, Xiao-Long Zhang, Yuan-Yuan Yang, Dong-Mei Fan, Yi-Zhi Zhang, Chen-Xuan Wu, Hong-Xing Guo, Yan-Jun Zhang, Ye Zhou, Dong-Sheng Xiong
Tumor antigens is at the core of cancer immunotherapy, however, the ideal antigen selection is difficult especially in poorly immunogenic tumors. In this study, we designed a strategy to modify hepatocellular carcinoma (HCC) cells by surface expressing anti-CD3scfv within the tumor site strictly, which depended on the E1A-engineered human umbilical cord mesenchymal stem cells (HUMSC.E1A) delivery system. Subsequently, membrane-bound anti-CD3scfv actived the lymphocytes which lysed HCC cells bypassing the expression of antigens or MHC restriction...
June 23, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28642791/efficacy-and-safety-of-ultrasound-guided-percutaneous-polidocanol-sclerotherapy-in-benign-cystic-thyroid-nodules-preliminary-results
#10
Xiaohua Gong, Qi Zhou, Fang Wang, Wenjun Wu, Xiaojun Chen
OBJECTIVE: To evaluate the efficacy and safety of percutaneous polidocanol injection (PPI) in treating cystic thyroid nodules. MATERIALS AND METHODS: A total of 158 cystic or predominantly cystic thyroid nodules (>80% cystic component) in 143 patients were evaluated. 114 patients with compressive symptoms or aesthetic complaints were offered PPI. 44 individuals without compressive symptoms and aesthetic complaints who were only followed up clinically were used as the control group...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28641500/levels-of-8-oxo-dgsn-and-8-oxo-gsn-in-random-urine-are-consistent-with-24%C3%A2-h-urine-in-healthy-subjects-and-patients-with-renal-disease
#11
Yong-Hui Mao, Qing-Hua Weng, Leng-Nan Xu, Xiang-Yu Li, Ban Zhao, Ying Sun, Jing-Jing Nie, Ji-Hong Hu, Qi Zhou, Li-Qun Zhang, Jian Guo, Ming-Zhang Zuo, Sadayoshi Ito, Jian-Ping Cai
Oxidatively generated damage to nucleic acids may play an important role in the pathophysiological processes of a variety of diseases. 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn) are oxidatively generated products of DNA and RNA, respectively. Our previous studies have suggested that the amounts of 8-oxo-dGsn and 8-oxo-Gsn in urine were considerably higher than other body fluid or tissue. The aim of this study was to investigate whether 8-oxo-dGsn and 8-oxo-Gsn levels in random urine samples are consistent with those in 24 h urine samples in healthy subjects and patients with renal disease...
June 23, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28640858/early-growth-stages-salinity-stress-tolerance-in-cm72-x-gairdner-doubled-haploid-barley-population
#12
Tefera Tolera Angessa, Xiao-Qi Zhang, Gaofeng Zhou, Sue Broughton, Wenying Zhang, Chengdao Li
A doubled haploid (DH) population of barley (Hordeum vulgare L.) generated from salinity tolerant genotype CM72 and salinity sensitive variety Gairdner was studied for salinity stress tolerance at germination, seedling emergence and first leaf full expansion growth stages. Germination study was conducted with deionized water, 150 mM and 300 mM NaCl treatments. Seedling stage salinity tolerance was conducted with three treatments: control, 150 mM NaCl added at seedling emergence and first leaf full expansion growth stages...
2017: PloS One
https://www.readbyqxmd.com/read/28640252/long-non-coding-rna-atb-promotes-malignancy-of-esophageal-squamous-cell-carcinoma-by-regulating-mir-200b-kindlin-2-axis
#13
Zhongwen Li, Xiaoliang Wu, Ling Gu, Qi Shen, Wen Luo, Chuangzhong Deng, Qianghua Zhou, Xinru Chen, Yanjie Li, ZuanFu Lim, Xing Wang, Jiahong Wang, Xianzi Yang
Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer-related death, especially in China. In addition, the prognosis of late stage patients is extremely poor. However, the biological significance of the long non-coding RNA lnc-ATB and its potential role in ESCC remain to be documented. In this study, we investigated the role of lnc-ATB and the underlying mechanism promoting its oncogenic activity in ESCC. Expression of lnc-ATB was higher in ESCC tissues and cell lines than that in normal counterparts...
June 22, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28640212/synthesis-and-in-vitro-anti-influenza-virus-evaluation-of-novel-sialic-acid-c-5-and-c-9-pentacyclic-triterpene-derivatives
#14
Xu Han, Long-Long Si, Yong-Ying Shi, Zi-Bo Fan, Shou-Xin Wang, Zhen-Yu Tian, Man Li, Jia-Qi Sun, Ping-Xuan Jiao, Fu-Xiang Ran, Yong-Min Zhang, De-Min Zhou, Su-Long Xiao
The emergence of drug resistant variants of the influenza virus has led to a great need to identify novel and effective antiviral agents. In our previous study, a series of sialic acid (C-2 and C-4)-pentacyclic triterpene conjugates have been synthesized, and a five-fold more potent antiviral activity was observed when sialic acid was conjugated with pentacyclic triterpene via C-4 than C-2. It was here that we further reported the synthesis and anti-influenza activity of novel sialic acid (C-5 and C-9)-pentacyclic triterpene conjugates...
June 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28640119/relationships-between-dorsolateral-prefrontal-cortex-metabolic-change-and-cognitive-impairment-in-first-episode-neuroleptic-naive-schizophrenia-patients
#15
Man-Li Huang, Thong-Teck Khoh, Shao-Jia Lu, Fen Pan, Jin-Kai Chen, Jian-Bo Hu, Shao-Hua Hu, Wei-Juan Xu, Wei-Hua Zhou, Ning Wei, Hong-Li Qi, De-Sheng Shang, Yi Xu
The present study aimed to explore the possible associations between the dorsolateral prefrontal cortex (DLPFC) metabolites and the cognitive function in first-episode schizophrenia (FES).This study included 58 patients with FES (29 males and 29 females; mean age, 22.66 ± 7.64 years) recruited from the First Affiliated Hospital, College of Medicine, Zhejiang University, and 43 locally recruited healthy controls (16 males and 27 females; mean age, 23.07 ± 7.49 years). The single-voxel proton magnetic resonance spectroscopy was used to measure the levels of N-acetylaspartate (NAA); complex of glutamate, glutamine, and γ-aminobutyric acid (Glx); choline-containing compounds; and myo-inositol in the DLPFC...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28639938/a-pilot-study-of-large-scale-production-of-mutant-pigs-by-enu-mutagenesis
#16
Tang Hai, Chunwei Cao, Haitao Shang, Weiwei Guo, Yanshuang Mu, Shulin Yang, Ying Zhang, Qiantao Zheng, Tao Zhang, Xianlong Wang, Yu Liu, Qingran Kong, Kui Li, Dayu Wang, Meng Qi, Qianlong Hong, Rui Zhang, Xiupeng Wang, Qitao Jia, Xiao Wang, Guosong Qin, Yongshun Li, Ailing Luo, Weiwu Jin, Jing Yao, Jiaojiao Huang, Hongyong Zhang, Menghua Li, Xiangmo Xie, Xuejuan Zheng, Kenan Guo, Qinhua Wang, Shibin Zhang, Liang Li, Fei Xie, Yu Zhang, Xiaogang Weng, Zhi Yin, Kui Hu, Yimei Cong, Peng Zheng, Hailong Zou, Leilei Xin, Jihan Xia, Jinxue Ruan, Hegang Li, Weiming Zhao, Jing Yuan, Zizhan Liu, Weiwang Gu, Ming Li, Yong Wang, Hongmei Wang, Shiming Yang, Zhonghua Liu, Hong Wei, Jianguo Zhao, Qi Zhou, Anming Meng
N-ethyl-N-nitrosourea (ENU) mutagenesis is a powerful tool to efficiently generate large scale of mutants and discover genes with novel functions at the whole-genome level in C. elegans, flies, zebrafish and mice, but has never been tried in large model animals. In the current study, we reported a successful systematic three-generation ENU mutagenesis screening in pigs with the establishment of Chinese Swine Mutagenesis Consortium. A total of 6,770 G1 and 6,800 G3 pigs were screened, 36 dominant and 91 recessive novel pig families with various phenotypes were established...
June 22, 2017: ELife
https://www.readbyqxmd.com/read/28638765/convenient-and-general-zinc-catalyzed-borylation-of-aryl-diazonium-salts-and-aryltriazenes-under-mild-conditions
#17
Xinxin Qi, Li-Bing Jiang, Chao Zhou, Jin-Bao Peng, Xiao-Feng Wu
A convenient and general zinc-catalyzed borylation of aryl diazonium salts and aryltriazenes has been developed. With bis- (pinacolato)diboron as the borylation reagent, aryldiazonium tetrafluoroborate salts and aryltriazenes were transformed into the corresponding arylboronates in moderate to excellent yields under mild conditions. As a convenient and practical methodology, no additional ligands, base, or any other additives are required here.
June 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28638476/therapeutic-inhibition-of-mir-4260-suppresses-colorectal-cancer-via-targeting-mcc-and-smad4
#18
Junjie Xiao, Dongchao Lv, Jinzhe Zhou, Yihua Bei, Ting Chen, Muren Hu, Qiulian Zhou, Siyi Fu, Qi Huang
Dysregulation of microRNAs (miRNAs, miRs) and their putative target genes have been increasingly reported to contribute to colorectal cancer. However, miRNAs that directly target the mutated in colorectal cancer (MCC) gene, a tumor suppressor which is downregulated or inactivated in colorectal cancer, remain largely unknown. By using an array-based miRNA analysis, we identified a group of miRNAs that were dysregulated in human metastatic versus non-metastatic colorectal cancer tissues. One of these miRNAs, miR-4260, was predicted to target MCC in the miRDB database...
2017: Theranostics
https://www.readbyqxmd.com/read/28638323/sortilin-fragments-deposit-at-senile-plaques-in-human-cerebrum
#19
Xia Hu, Zhao-Lan Hu, Zheng Li, Chun-Sheng Ruan, Wen-Ying Qiu, Aihua Pan, Chang-Qi Li, Yan Cai, Lu Shen, Yaping Chu, Bei-Sha Tang, Huaibin Cai, Xin-Fu Zhou, Chao Ma, Xiao-Xin Yan
Genetic variations in the vacuolar protein sorting 10 protein (Vps10p) family have been linked to Alzheimer's disease (AD). Here we demonstrate deposition of fragments from the Vps10p member sortilin at senile plaques (SPs) in aged and AD human cerebrum. Sortilin changes were characterized in postmortem brains with antibodies against the extracellular and intracellular C-terminal domains. The two antibodies exhibited identical labeling in normal human cerebrum, occurring in the somata and dendrites of cortical and hippocampal neurons...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28637758/genome-wide-analysis-of-eighteen-epstein-barr-viruses-isolated-from-primary-nasopharyngeal-carcinoma-biopsies
#20
Chaofeng Tu, Zhaoyang Zeng, Peng Qi, Xiayu Li, Zhengyuan Yu, Can Guo, Fang Xiong, Bo Xiang, Ming Zhou, Zhaojian Gong, Qianjin Liao, Jianjun Yu, Yi He, Wenling Zhang, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong
Epstein-Barr virus (EBV) is a ubiquitous gamma-herpesvirus that is highly prevalent in almost all human populations, and is associated with many human cancers such as nasopharyngeal carcinoma (NPC), Hodgkin's disease, and gastric carcinoma. However, in these EBV-associated cancers, only NPC exhibits remarkable ethnic and geographic distribution. We hypothesized that EBV genomic variations might contribute to the pathogenesis of different human cancers in different geographic areas. In this study, we collected 18 NPC biopsies from the Hunan Province in Southern China and de novo assembled 18 NPC biopsy specimen-derived EBV (NPC-EBV) genomes, designated as HN1 to HN18...
June 21, 2017: Journal of Virology
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