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https://www.readbyqxmd.com/read/28231545/aqueous-extract-of-cortex-dictamni-protects-h9c2-cardiomyocytes-from-hypoxia-reoxygenation-induced-oxidative-stress-and-apoptosis-by-pi3k-akt-signaling-pathway
#1
Lin Li, Yunfeng Zhou, Yanlin Li, Lili Wang, Lan Sun, Lidong Zhou, Hiderori Arai, Yun Qi, Yang Xu
Ischemia-reperfusion injury is the major manifestation of ischemic heart disease, which facilitates cardiac arrhythmias, heart failure and death. Oxidative stress and apoptosis have been involved in the pathogenesis of myocardial ischemia-reperfusion injury. Modern pharmacological studies have indicated that the extracts and active compounds of Cortex Dictamni exhibit antioxidative and cardiovascular protective activities. This study was designed to investigate the protective effect of aqueous extract of Cortex Dictamni (CDAE) on regulating hypoxia/reoxygenation (H/R)-induced cardiomyocytes oxidative stress and apoptosis...
February 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28230987/urinary-antibiotics-of-pregnant-women-in-eastern-china-and-cumulative-health-risk-assessment
#2
Hexing Wang, Na Wang, Junhua Qian, Lingyun Hu, Peixin Huang, Meifang Su, Xin Yu, Chaowei Fu, Feng Jiang, Qi Zhao, Ying Zhou, Haijiang Lin, Gengsheng He, Yue Chen, Qingwu Jiang
Exposure to antibiotics during pregnancy can pose a systematic effect on human health. A few bio-monitoring studies have demonstrated an extensive exposure of children to antibiotics, but there is still lack of data for pregnant women. To assess the exposure of pregnant women to antibiotics and potential health risk, we investigated 536 pregnant women aged 16-42 years from two geographically different study sites in Eastern China in 2015. We measured 21 antibiotics of five categories (seven fluoroquinolones, three phenicols, four tetracyclines, three macrolides, and four sulfonamides) in urines by using the isotope dilution ultra-performance liquid chromatography coupled to quadrupole time of-flight mass spectrometry...
February 23, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28230294/asymmetric-total-syntheses-of-kopsia-indole-alkaloids
#3
Lingying Leng, Xiaohan Zhou, Qi Liao, Falu Wang, Hao Song, Dan Zhang, Xiao-Yu Liu, Yong Qin
The asymmetric total syntheses of a group of structurally complex Kopsia alkaloids, (-)-kopsine, (-)-isokopsine, (+)-methyl chanofruticosinate, (-)-fruticosine, and (-)-kopsanone, has been achieved. The key strategies for the construction of the molecular complexity in the targets included an asymmetric Tsuji-Trost rearrangement to set the first quaternary carbon center at C20, an intramolecular cyclopropanation by diazo decomposition to install the second and third quaternary carbon centers at C2 and C7, respectively, and a SmI2 -promoted acyloin condensation to assemble the isokopsine core...
February 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28230187/silencing-salusin-%C3%AE-attenuates-cardiovascular-remodeling-and-hypertension-in-spontaneously-hypertensive-rats
#4
Xing-Sheng Ren, Li Ling, Bing Zhou, Ying Han, Ye-Bo Zhou, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
Salusin-β is a bioactive peptide involved in vascular smooth muscle cell proliferation, vascular fibrosis and hypertension. The present study was designed to determine the effects of silencing salusin-β on hypertension and cardiovascular remodeling in spontaneously hypertensive rats (SHR). Thirteen-week-old male SHR and normotensive Wistar-Kyoto rats (WKY) were subjected to intravenous injection of PBS, adenoviral vectors encoding salusin-β shRNA (Ad-Sal-shRNA) or a scramble shRNA. Salusin-β levels in plasma, myocardium and mesenteric artery were increased in SHR...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28230177/storage-of-passive-motion-pattern-in-hippocampal-ca1-region-depends-on-camkii-creb-signaling-pathway-in-a-motion-sickness-rodent-model
#5
Junqin Wang, Jiluo Liu, Leilei Pan, Ruirui Qi, Peng Liu, Wei Zhou, Yiling Cai
Sensory mismatch between actual motion information and anticipated sensory patterns (internal model) is the etiology of motion sickness (MS). Some evidence supports that hippocampus might involve the neural storage of the "internal model". This study established an "internal model" acquisition-retention behavioral model using a repeated habituation rotation training protocol. We tried to identify the hippocampal subregion involved in "internal model" retention using chemical lesion methods. Hippocampal kinases (CaMK, CaMKIV, CREB and ERK1/2) phosphorylation in the target subregion was assayed and the effects of kinase inhibitors (KN93 or U0126) on "internal model" retention were investigated...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229997/pregnancy-combined-with-epilepsy-and-cerebral-cavernous-malformation
#6
Ya-Lan Xu, Jun-Tao Liu, Yi-Jun Song, Xi-Ya Zhou, Qing-Wei Qi, Xu-Ming Bian, Zhi-Qin Xu, Lei Li
No abstract text is available yet for this article.
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28228400/inhibiting-aerobic-glycolysis-suppresses-renal-interstitial-fibroblasts-activation-and-renal-fibrosis
#7
Hao Ding, Lei Jiang, Jing Xu, Feng Bai, Yang Zhou, Qi Yuan, Jing Luo, Ke Zen, Junwei Yang
Chronic kidney diseases (CKD) generally lead to renal fibrosis. Despite great progresses have been made in identifying molecular mediators of fibrosis, the mechanism that governs renal fibrosis remains unclear and so far no effective therapeutic anti-fibrosis strategy is available. Here we demonstrated that a switch of metabolism from oxidative phosphorylation to aerobic glycolysis (Warburg effect) in renal fibroblasts was the primary feature of fibroblast activation during renal fibrosis, and that suppressing renal fibroblast aerobic glycolysis could significantly reduce renal fibrosis...
February 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28227552/research-on-eeg-features-of-attended-unattended-vigilance
#8
Chang Sun, Runge Chen, Miao Tian, Xingwei An, Hongzhi Qi, Minpeng Xu, Xuemin Wang, Dong Ming, Peng Zhou, Chang Sun, Runge Chen, Miao Tian, Xingwei An, Hongzhi Qi, Minpeng Xu, Xuemin Wang, Dong Ming, Peng Zhou, Miao Tian, Minpeng Xu, Hongzhi Qi, Runge Chen, Dong Ming, Chang Sun, Xingwei An, Peng Zhou, Xuemin Wang
Vigilance refers to the brain alertness to objective things, including the concentration of attention and the capability to response emergencies. It is of great importance to study vigilance monitoring to avoid accidents caused by decrease of vigilance. In this study, traditional Mackworth Clock Test (MCT) was modified to induce decline of attended and unattended vigilance. We analyzed EEG features in different levels of attended vigilance and assessed unattended vigilance by amplitude of mismatch negative (MMN) which can be evoked by audio odd ball stimulations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225668/emergence-of-indigenous-artemisinin-resistant-plasmodium-falciparum-in-africa
#9
Feng Lu, Richard Culleton, Meihua Zhang, Abhinay Ramaprasad, Lorenz von Seidlein, Huayun Zhou, Guoding Zhu, Jianxia Tang, Yaobao Liu, Weiming Wang, Yuanyuan Cao, Sui Xu, Yaping Gu, Julin Li, Chao Zhang, Qi Gao, Didier Menard, Arnab Pain, Haitao Yang, Qingfeng Zhang, Jun Cao
No abstract text is available yet for this article.
February 22, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28225559/effects-of-an-alternative-oxidase-gene-on-conidia-viability-under-external-stresses-in-monascus-ruber-m7
#10
Yanchun Shao, Qi Li, Youxiang Zhou, Fusheng Chen
Monascus species can produce natural edible pigments and many other bioactive metabolites. In this study, mraox gene (Monascus ruber alternative oxidase) was isolated, sequenced, and replaced in order to investigate the function in resistance of conidia to stressful conditions. The derived protein of the mraox gene consisted of 350 amino acids with a conserved ferritin-like diiron-binding domain at the C-terminus, sharing a high homolog with alternative oxidase proteins in other filamentous fungi. Deletion of mraox gene repressed the conidia germination rate (CGR) when conidia were exposed to H2 O2 , high temperature (40 and 50 °C) and alkerline buffer (pH8...
February 22, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28225064/intravoxel-incoherent-motion-diffusion-weighted-mr-imaging-in-assessing-and-characterizing-solitary-pulmonary-lesions
#11
Qi Wan, Ying-Shi Deng, Jia-Xuan Zhou, Yu-Dong Yu, Ying-Ying Bao, Qiang Lei, Hou-Jin Chen, Ya-Hui Peng, Ying-Jie Mei, Qing-Si Zeng, Xin-Chun Li
This study aimed to investigate the potential of intravoxel incoherent motion (IVIM) diffusion-weighted MR imaging in assessing solitary pulmonary lesions (SPLs). Sixty-two patients with pathologically confirmed SPLs, including 51 and 11 cases of malignant and benign lesions, respectively, were assessed. Diffusion weighted imaging (DWI) with 13 b values was used to derive apparent diffusion coefficient (ADC) and IVIM parameters, including true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f)...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224425/mechanism-of-dynamic-near-infrared-fluorescence-cholangiography-of-extrahepatic-bile-ducts-and-applications-in-detecting-bile-duct-injuries-using-indocyanine-green-in-animal-models
#12
Yang Gao, Min Li, Zi-Fang Song, Le Cui, Bi-Rong Wang, Xiao-Ding Lou, Tao Zhou, Yong Zhang, Qi-Chang Zheng
Fluorescence intraoperative cholangiography (IOC) is a potential alternative for identifying anatomical variation and preventing iatrogenic bile duct injuries by using the near-infrared probe indocyanine green (ICG). However, the dynamic process and mechanism of fluorescence IOC have not been elucidated in previous publications. Herein, the optical properties of the complex of ICG and bile, dynamic fluorescence cholangiography and iatrogenic bile duct injuries were investigated. The emission spectrum of ICG in bile peaked at 844 nm and ICG had higher tissue penetration...
February 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28224420/early-osseointegration-of-implants-with-cortex-like-tio2-coatings-formed-by-micro-arc-oxidation-a-histomorphometric-study-in-rabbits
#13
Hong-Zhi Zhou, Ya-da Li, Lin Liu, Xiao-Dong Chen, Wei-Qiang Wang, Guo-Wu Ma, Yu-Cheng Su, Min Qi, Bin Shi
In our previous studies, a novel cortex-like TiO2 coating was prepared on Ti surface through micro-arc oxidation (MAO) by using sodium tetraborate as electrolyte, and the effects of the coating on cell attachment were testified. This study aimed to investigate the effects of this cortex-like MAO coating on osseointegration. A sand-blasting and acid-etching (SLA) coating that has been widely used in clinical practice served as control. Topographical and chemical characterizations were conducted by scanning electron microscopy, energy dispersive X-ray spectrometer, X-ray diffraction, contact angle meter, and step profiler...
February 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28223078/effects-of-total-solids-content-on-performance-of-sludge-mesophilic-anaerobic-digestion-and-dewaterability-of-digested-sludge
#14
Dong An, Tianfeng Wang, Qi Zhou, Chaosheng Wang, Qiyong Yang, Bingjie Xu, Qingfang Zhang
The role of total solids (TS) content on sludge mesophilic anaerobic digestion (AD) was investigated in batch reactors. A range of TS below 10% was evaluated with two replicates. The volumetric biogas production rate (VBPR) increased with increasing initial TS. On day 5, VBPR increased from 133.2±11.2mLL(-1)d(-1) at TS 2% to 1111.7±58.1mLL(-1)d(-1) at TS 10%. The ultimate biogas yield (P) firstly increased and then decreased with the increasing TS. The greatest P was 246.8mLg(-1)-VSadded at TS 8%. The corresponding free ammonia nitrogen (FAN) and total ammonia nitrogen (TAN) were 84...
February 17, 2017: Waste Management
https://www.readbyqxmd.com/read/28222426/knockdown-of-pd-l1-in-human-gastric-cancer-cells-inhibits-tumor-progression-and-improves-the-cytotoxic-sensitivity-to-cik-therapy
#15
Jing Li, Lujun Chen, Yuqi Xiong, Xiao Zheng, Quanqin Xie, Qi Zhou, Liangrong Shi, Changping Wu, Jingting Jiang, Haitao Wang
: Background/Abstract: PD-L1 has been an important target of cancer immunotherapy. We have showed that in human gastric cancer tissues, over-expression of PD-L1 was significantly associated with cancer progression and patients' postoperative prognoses. However, as of now, how PD-L1 regulates the biological function of gastric cancer cells still remains elusive. METHODS: We constructed the stable PD-L1 knockdown expression gastric cancer cell lines by using RNAi method, and further investigated the changes of biological functions including cell viability, migration, invasion, cell cycle, apoptosis, tumorigenicity in vivo, and the cytotoxic sensitivity to CIK therapy, in contrast to the control cells...
February 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28220884/exploration-of-the-role-of-gene-mutations-in-myelodysplastic-syndromes-through-a-sequencing-design-involving-a-small-number-of-target-genes
#16
Feng Xu, Ling-Yun Wu, Qi He, Dong Wu, Zheng Zhang, Lu-Xi Song, You-Shan Zhao, Ji-Ying Su, Li-Yu Zhou, Juan Guo, Chun-Kang Chang, Xiao Li
Novel sequencing designs are necessary to supplement the recognized knowledge of myelodysplastic syndrome (MDS)-related genomic alterations. In this study, we sequenced 28 target genes in 320 Chinese MDS patients but obtained 77.2% of recall factors and 82.8% of genetic abnormalities (including karyotype abnormalities). In addition to known relationships among mutations, some specific chromosomal abnormalities were found to link to specific gene mutations. Trisomy 8 tended to be linked to U2AF1 and ZRSR2 mutations, and 20q- exhibited higher SRSF2/WT1 and U2AF1 mutation frequency...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220844/waist-to-height-ratio-is-an-effective-indicator-for-comprehensive-cardiovascular-health
#17
Shiwei Shen, Yun Lu, Huajin Qi, Feng Li, Zhenhai Shen, Liuxin Wu, Chengjian Yang, Ling Wang, Kedong Shui, Weifeng Yao, Dongchang Qiang, Jingting Yun, Lin Zhou
The aim of this study was to determine the associations between cardiovascular health and the waist circumference (WC) and waist-to-height ratio (WHtR). A cross-sectional study was performed recruiting 26701 middle-aged Chinese men. Of the seven ideal cardiovascular health metrics, body mass index (BMI), total cholesterol (TC), blood pressure (BP), and fasting blood glucose (FBG) were found to increase with an elevation of the mean WC and WHtR. The mean WC and WHtR were significantly lower in the subjects with intermediate or ideal cardiovascular health than those with poor or intermediate health...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220812/status-of-hbsag-seroprevalence-in-15-million-rural-couples-in-china-a-cross-sectional-study
#18
Long Zhang, Yuan-Yuan Wang, Yan-Jie Huang, Qiao-Mei Wang, Kenrad E Nelson, An-Qi Wang, Hai-Ping Shen, Xiao-Li Liu, Yi-Ping Zhang, Dong-Hai Yan, Zuo-Qi Peng, Hong-Guang Zhang, Ya Zhang, Jun Zhao, Yan Wang, Ying Yang, Yuan He, Ji-Hong Xu, Du-Jia Liu, Tong-Jun Guo, Xiao-Na Xin, Hong Zhou, Xu Ma
A cross-sectional analysis of prevalence of hepatitis B virus infection (HBV) among rural couples was conducted between 2010 and 2014. Serologic HBV markers, including hepatitis B surface antigen (HBsAg) and e antigen (HBeAg), were tested. Primary outcome of interest comprised HBsAg positivity in couples (both positive: F+M+, only wife positive: F+M-, only husband positive: F-M+), and secondary outcome consisted of prevalence and risk factors of HBsAg positivity among husbands or wives. Of 14,816,300 couples included, 0...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220687/environmental-factors-seven-gwas-identified-susceptibility-loci-and-risk-of-gastric-cancer-and-its-precursors-in-a-chinese-population
#19
Meng Cai, Shuyang Dai, Wanqing Chen, Changfa Xia, Lingeng Lu, Shuguang Dai, Jun Qi, Minjie Wang, Meilin Wang, Lanping Zhou, Fuhua Lei, Tingting Zuo, Hongmei Zeng, Xiaohang Zhao
Gene-environment interactions may increase gastric cancer (GC) risk. Seven susceptibility loci identified by genome-wide association studies (GWASs) suggest that genetic factors play a role in gastric carcinogenesis. Meanwhile, Helicobacter pylori (H. pylori) infection, smoking, and alcohol drinking are also important environmental factors for gastric cancer. However, studies to explore the role of gene-environment interactions in gastric carcinogenesis, and particularly the relationship between the seven susceptibility loci and their potential interactions with H...
February 21, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28219151/-the-disease-burden-for-low-back-pain-in-china-1990-and-2013
#20
W L Dong, Y C Li, S W Liu, Y Y Jiang, F Mao, L Qi, X Y Zeng, M G Zhou
Objective: To assess the disease burden for low back pain in China in 2013 and analyzed the change of it between 1990 and 2013. Methods: Data was from the Global Burden of Disease Study 2013 (GBD 2013). The burden of low back pain (LBP) among age groups, gender groups, provinces (excluding Taiwan China) groups was assessed by years lived with disability (YLD), including YLD, YLD rate, proportion of YLD due to LBP. The change of the YLD for LBP was analyzed between 1990 and 2013 by age-standardized YLD rate using the world standard population of 2000-2025 WHO...
February 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
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