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Iron deficiency anaemia

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https://www.readbyqxmd.com/read/28229219/prevalence-and-clinical-impact-of-iron-deficiency-and-anaemia-among-outpatients-with-chronic-heart-failure-the-prep-registry
#1
Stephan von Haehling, Uwe Gremmler, Michael Krumm, Frank Mibach, Norbert Schön, Jens Taggeselle, Johannes B Dahm, Christiane E Angermann
BACKGROUND: Iron deficiency (ID) and anaemia are common in heart failure (HF). The prospective, observational PReP registry (Prävalenz des Eisenmangels bei Patienten mit Herzinsuffizienz) studied prevalence and clinical impact of ID and anaemia in HF outpatients attending cardiology practices in Germany. METHODS AND RESULTS: A total of 42 practices enrolled consecutive patients with chronic HF [left ventricular ejection fraction (LVEF) ≤45%]. ID was defined as serum ferritin <100 µg/l, or serum ferritin ≥100 µg/l/<300 µg/l plus transferrin saturation <20%, and anaemia as haemoglobin <13 g/dl (12 g/dl) in men (women)...
February 22, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28216981/real-case-of-primitive-embryonal-duodenal-carcinoma-in-a-young-man
#2
Julien Barbieux, Riccardo Memeo, Vito De Blasi, Sebastian Suciu, Vanina Faucher, Gerlinde Averous, Catherine Roy, Jacques Marescaux, Didier Mutter, Patrick Pessaux
We report here the case of a young man suffering from a rare germ cell tumour. The patient was a 25-year-old man who was referred to our centre for asthenia, stinging epigastric pain, and an iron deficiency anaemia. Gastroscopy revealed a circumferential vegetating lesion on the second portion of the duodenum. The lesion was indurated at the third portion of the duodenum, responsible for a tight stenosis. A computerized tomography-scan of the chest, abdomen and pelvis, and a pancreatic MRI showed a circumferential lesion with a bi-ductal dilatation (i...
January 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28211569/microcytic-anaemias-in-childhood-and-iron-refractory-iron-deficiency-anaemia
#3
EDITORIAL
Martin J Pippard
No abstract text is available yet for this article.
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28209005/serum-iron-and-haemoglobin-estimation-in-oral-submucous-fibrosis-and-iron-deficiency-anaemia-a-diagnostic-approach
#4
Divya Bhardwaj, Ajit D Dinkar, Sujata K Satoskar, Sapna Raut Desai
INTRODUCTION: Oral Submucous Fibrosis (OSMF) is a premalignant condition with potential malignant behaviour characterized by juxta-epithelial fibrosis of the oral cavity. In the process of collagen synthesis, iron gets utilized, by the hydroxylation of proline and lysine, leading to decreased serum iron levels. The trace element like iron is receiving much attention in the detection of oral cancer and precancerous condition like OSMF as it was found to be significantly altered in these conditions...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28198025/haemoglobin-responses-to-transfusion-in-severe-iron-deficiency-anaemia-potential-impact-of-gastrointestinal-disorders
#5
X Bosch, E Montori, M Guerra-García, J Costa-Rodríguez, M H Quintanilla, P E Tolosa-Chapasian, P Moreno, N Guasch, A López-Soto
BACKGROUND AND OBJECTIVES: Red blood cell (RBC) transfusion may be justified in iron deficiency anaemia (IDA) when an increase in oxygen delivery is needed, as sometimes occurs in subjects with haemoglobin <8·0 mg/dL, serious comorbidities or at risk of cardiovascular instability. Earlier investigations showed that some patients with severe IDA requiring transfusion had lower than expected post-transfusion haemoglobin levels with poorer clinical outcomes than other patients. After hypothesizing that haemoglobin responses to transfusion were different and that the underlying gastrointestinal (GI) disorders causing IDA could be a confounder explaining this association, these responses were analysed in a prospective cohort of IDA adults referred for outpatient GI investigation...
February 15, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28191814/the-pathophysiologic-basis-of-anaemia-in-patients-with-malignant-diseases
#6
Umma A Ibrahim, Aminu A Yusuf, Sagir G Ahmed
Cancer patients frequently present with anaemia that may result from the direct or indirect effects of the tumor or its treatment. Anaemia is an independent adverse prognostic factor that exerts negative influence on quality of life and survival of cancer patients. Anaemia in malignant disorders often arises from an interplay of multiple aetiological and pathophysiologic mechanisms. Understanding these mechanisms will help the oncologist identify and treat specific causes of the anaemia thereby minimizing the use of blood transfusion, which is associated with many adverse effects...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28191453/anti-tnf-mediated-modulation-of-prohepcidin-improves-iron-availability-in-inflammatory-bowel-disease-in-an-il-6-mediated-fashion
#7
Flaminia Cavallaro, Lorena Duca, Laura Francesca Pisani, Roberta Rigolini, Luisa Spina, Gian Eugenio Tontini, Nadia Munizio, Elena Costa, Maria Domenica Cappellini, Maurizio Vecchi, Luca Pastorelli
Background. Anaemia is common in inflammatory bowel disease (IBD), frequently resulting from a combination of iron deficiency and of anaemia of chronic disease (ACD). ACD is characterized by macrophage iron retention induced by proinflammatory cytokines. Hepcidin is the master inducer of iron accumulation during ACD, and its production is mainly regulated by IL-6 and the novel erythroid hormone erythroferrone (ERFE). This study evaluates whether anti-TNF monoclonal antibodies therapy modurates hepcidin production and the levels of its main regulators, leading to a restoration of iron homeostasis...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28182020/effect-of-ayurveda-medications-kas%C3%A4-sa-bhasma-and-dh%C3%A4-tr%C3%A4-avaleha-on-iron-deficiency-anaemia-a-randomized-controlled-study
#8
Basavaraj Ramappa Tubaki, Jyoti Mahadev Benni, Niranjan Rao, Uchangi Nagaraja Rao Prasad
BACKGROUND: This paper explores the role that Ayurveda can play in the management of Iron Deficiency Anaemia, a major nutritional deficiency disorder affecting people across the globe. METHODOLOGY: Forty (40) patients suffering from Iron deficiency anaemia as per WHO guidelines, between the age group of 20 to 60 yrs of either sex participated in the study. Study was a randomized, controlled, open label clinical study. Patients were randomly divided into two groups: Group D (n = 20) received Dhārī avaleha 10 g twice a day after food...
July 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/28179703/evaluation-of-five-discriminating-indexes-to-distinguish-beta-thalassemia-trait-from-iron-deficiency-anaemia
#9
Zahid Ullah, Aamer Ali Khattak, Sara Arif Ali, Javaid Hussain, Badshah Noor, Raheela Bano, Muhammad Amin Jan Mahsud
OBJECTIVE: To assess the reliability of different red blood cell indices-based formulae in the indexes formula in differential diagnosis of beta thalassemia trait and iron deficiency anaemia. METHODS: This cross-sectional study was conducted between January and October 2015 in Dera Ismail Khan in the Khyber Pakhtunkhwa province of Pakistan. Patients of beta thalassemia trait and iron deficiency anaemia were registered irrespective of age and gender. About 5 mL of blood was taken from each patient to analyse different red cell parameters like red blood cell count, haemoglobin, mean cell volume, mean cell haemoglobin, mean cell haemoglobin concentration, and red cell distribution width...
December 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28175185/p620-network-meta-analysis-of-efficacy-and-safety-of-different-intravenous-iron-compounds-for-the-treatment-of-iron-deficiency-anaemia-in-patients-with-inflammatory-bowel-disease
#10
A Aksan, H Işık, H H Radeke, A Dignass, J Stein
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172956/p533-anaemia-and-iron-deficiency-in-gastroenterology-a%C3%A2-scandinavian-prospective-observational-study-of-iron-isomaltoside-in-clinical-practice
#11
S O Frigstad, P Hammarlund, O Bonderup, T Rannem, A Haaber, J Fallingborg, H Blom, A Bajor, P M Hellström
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172952/p328-patient-and-physician-perspectives-on-managing-iron-deficiency-with-or-without-anaemia-in-inflammatory-bowel-disease-findings-from-a-european-online-survey
#12
S Danese, J P Gisbert, A J Lobo, A Dignass, L Peyrin-Biroulet, M Kokot, L Avedano
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172626/p456-comparative-analysis-of-oral-versus-intravenous-iron-in-patients-with-inflammatory-bowel-disease-and-iron-deficiency-anaemia-impact-on-hospitalisation-in-germany
#13
K Borchert, T Hardt, J S Haas, S H Ong, E Lechat, K Nip, D Foerster, S Braun, J Stein
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28169443/systematic-evaluation-of-paediatric-cohort-with-iron-refractory-iron-deficiency-anaemia-irida-phenotype-reveals-multiple-tmprss6-gene-variations
#14
Prateek Bhatia, Aditya Singh, Avani Hegde, Richa Jain, Deepak Bansal
Systematic screening identified patients with an iron refractory iron deficiency anaemia (IRIDA) phenotype and genotype in iron-deficient children in the Indian subcontinent. Cases of moderate to severe microcytosis and anaemia with no obvious cause and normal C-reactive protein, HbA2 and tissue transglutaminase antibody levels (n = 550) were put on a trial of oral iron for 4 weeks. Sixty of these 550 cases (11%) were variably refractory to oral iron therapy (<10 g/l Hb rise) at 4-6 weeks and were subsequently evaluated for plasma iron, ferritin and hepcidin levels...
February 7, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28151394/a-fast-track-anaemia-clinic-in-the-emergency-department-cost-analysis-of-intravenous-iron-administration-for-treating-iron-deficiency-anaemia
#15
Manuel Quintana-Díaz, Raúl Muñoz-Romo, Susana Gómez-Ramírez, José Pavía, Alberto M Borobia, José A García-Erce, Manuel Muñoz
BACKGROUND: A fast-track anaemia clinic (FTAC) for the management of moderate-to-severe iron-deficiency anaemia (IDA) was established in our Emergency Department in 2010. In this FTAC, the replacement of packed red cell transfusion by ferric carboxymaltose administration was proven to be safe and effective. The aim of this study was a cost-analysis of IDA management in the FTAC, comparing this management with the previous standard care pathway consisting of packed red cell transfusion, if needed, and referral to outpatient specialised care...
January 24, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28151393/genetic-factors-associated-with-iron-storage-in-australian-blood-donors
#16
Yu Ji, Robert Flower, Catherine Hyland, Nargess Saiepour, Helen Faddy
BACKGROUND: Blood donors are at risk of developing iron deficiency and/or iron deficiency anaemia. This may affect their health and affect their eligibility to give subsequent donations. Investigating genetic factors that may predispose donors to high or low iron stores is of interest; this may assist with providing optimal management strategies for maintaining donor health. This study aimed to investigate whether the presence of selected single nucleotide polymorphisms (SNPs) affecting parameters of iron status were associated with ferritin levels in Australian donors...
December 20, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28129772/effect-of-a-short-course-of-iron-polymaltose-on-acquisition-of-malarial-parasitaemia-in-anaemic-indonesian-schoolchildren-a-randomized-trial
#17
Margaretta A Prasetyani, Quirijn de Mast, Robel Afeworki, Maria M M Kaisar, Difa Stefanie, Erliyani Sartono, Taniawati Supali, André J van der Ven
BACKGROUND: Concern exists about the safety of iron supplementation given to individuals in malarious areas. The possible unfavourable impact of iron supplementation on malaria might be less when slow-release iron compounds are used instead of ferrous salts, because no toxic non-transferrin bound iron is formed. The aim of this study was to determine the effect of iron supplementation using the slow-release iron compound iron polymaltose (IPM) on the acquisition of malarial parasitaemia...
January 28, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28126204/the-relationship-between-iron-level-and-thyroid-function-during-the-first-trimester-of-pregnancy-a-cross-sectional-study-in-wuxi-china
#18
Jinyan Fu, Anqiang Yang, Jun Zhao, Yunlong Zhu, Ying Gu, Yaohui Xu, Daozhen Chen
Our objective was to evaluate the relationship between iron level and thyroid function during the first trimester of pregnancy in Eastern China. This was a hospital-based, cross-sectional observational study. A total of 1764 pregnant women were enrolled during their first trimester of gestation in Wuxi city. Serum ferritin (SF), hemoglobin (Hb), urinary iodine concentrations (UIC), thyroid-stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) were measured and evaluated in pregnant women...
January 22, 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28120735/prevalence-of-anaemia-deficiencies-of-iron-and-vitamin-a-and-their-determinants-in-rural-women-and-young-children-a-cross-sectional-study-in-kalal%C3%A3-district-of-northern-benin
#19
Halimatou Alaofè, Jennifer Burney, Rosamond Naylor, Douglas Taren
OBJECTIVE: To identify the magnitude of anaemia and deficiencies of Fe (ID) and vitamin A (VAD) and their associated factors among rural women and children. DESIGN: Cross-sectional, comprising a household, health and nutrition survey and determination of Hb, biochemical (serum concentrations of ferritin, retinol, C-reactive protein and α1-acid glycoprotein) and anthropometric parameters. Multivariate logistic regression examined associations of various factors with anaemia and micronutrient deficiencies...
January 25, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28117617/patterns-and-determinants-of-functional-and-absolute-iron-deficiency-in-patients-undergoing-cardiac-rehabilitation-following-heart-surgery
#20
Roberto Tramarin, Valeria Pistuddi, Luigi Maresca, Marco Pavesi, Serenella Castelvecchio, Lorenzo Menicanti, Carlo de Vincentiis, Marco Ranucci
Background Anaemia and iron deficiency are frequent following major surgery. The present study aims to identify the iron deficiency patterns in cardiac surgery patients at their admission to a cardiac rehabilitation programme, and to determine which perioperative risk factor(s) may be associated with functional and absolute iron deficiency. Design This was a retrospective study on prospectively collected data. Methods The patient population included 339 patients. Functional iron deficiency was defined in the presence of transferrin saturation <20% and serum ferritin ≥100 µg/l...
January 1, 2017: European Journal of Preventive Cardiology
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