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Iron deficiency anaemia

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https://www.readbyqxmd.com/read/29144533/anaemia-and-iron-deficiency-in-heart-failure-epidemiological-gaps-diagnostic-challenges-and-therapeutic-barriers-in-sub-saharan-africa
#1
REVIEW
Abel Makubi, Johnson Lwakatare, Okechukwu S Ogah, Lars Rydén, Lars H Lund, Julie Makani
Anaemia and iron deficiency (ID) are common and of prognostic importance in heart failure (HF). In both conditions the epidemiology, diagnosis and therapies have been extensively studied in high-income countries but are still largely unexplored in sub-Saharan Africa (SSA). The lack of adequate and robust epidemiological data in SSA makes it difficult to recognise the significance of anaemia and ID in HF. From a clinical perspective, less attention is paid by clinicians to screening for anaemia in HF, and as far as interventions are concerned, there are no clinical trials in SSA that provide guidance on the appropriate interventional approach...
September 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29138283/frequency-of-and-reasons-for-paroxysmal-nocturnal-haemoglobinuria-screening-in-patients-with-unexplained-anaemia
#2
James T England, Bakul Dalal, Heather A Leitch
Referral to hematology for anemia is common. In paroxysmal nocturnal hemoglobinuria (PNH), cells deficient in the glycosylphosphatidyl inositol (GPI) anchor are lysed by complement. Eculizumab improves overall survival and quality of life while reducing hemolysis, transfusion requirements, and thrombosis. We evaluated the frequency of screening for PNH in patients with unexplained anemia. Key clinical features, laboratory data, and investigations were recorded for patients referred for anemia since 2010, without a specific cause found...
November 14, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29133111/effect-of-oral-contraception-on-anemia-in-12-low-and-middle-income-countries
#3
S Bellizzi, M M Ali
CONTEXT: In low and middle-income countries anaemia is a major public health issue in women of reproductive age for a series of factors including iron deficiency. OBJECTIVE: To estimate prevalence of anemia and to assess the association of low level of haemoglobin versus duration of use of oral contraceptives (OC). METHODS: Demographic and health survey (DHS) of 12 countries, conducted between 2005 and 2012, were analyzed. The status of anemia was separately evaluated for non-pregnant women using OC for at least six months, one year, and two years, and for women using no method of contraception and/or using non-hormonal contraception...
November 10, 2017: Contraception
https://www.readbyqxmd.com/read/29129158/practical-gastrointestinal-investigation-of-iron-deficiency-anaemia
#4
Anjan K Banerjee, Valerio Celentano, Jim Khan, Gaius Longcroft-Wheaton, Amanda Quine, Pradeep Bhandari
About 10% of oesophagogastroduodenoscopies (OGDs) and colonoscopies are done for investigation of iron deficiency anemia (IDA) . Much of the existing guidance on investigation of IDA predates CRC screening, which has driven significant improvements in colonoscopy quality and completion rates, as well as a reduction in Helicobacter pylori prevalence and increase in PPI usage, and therefore probably needs re-consideration. New investigations, e.g. CT colonography, enteroscopy and capsule endoscopy have also been introduced...
November 13, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29127130/eosinophilic-oesophagitis-and-coeliac-disease-is-there-an-association
#5
Ana Margarida Vaz, Antonio Jesus Cadilla, Diamantino Sousa, Horácio Guerreiro
A 25-year-old man was seen in outpatient clinic for progressive solid food dysphagia. He was already medicated with a proton pump inhibitor with no improvement. His blood tests showed a slight microcytic anaemia and peripheral eosinophilia. The oesophago-gastro-duodenoscopy showed longitudinal furrows in the distal two-thirds of the oesophagus and a concentric distal stenosis. The biopsies taken showed eosinophilic infiltrates consistent with eosinophilic oesophagitis. There was no improvement with topical fluticasone, so the patient was started on a systemic corticosteroid with resolution of dysphagia and of the oesophageal stenosis...
November 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29114147/malaria-induced-anaemia-and-serum-micronutrients-in-asymptomatic-plasmodium-falciparum-infected-patients
#6
Babamale O Abdulkareem, Abdulkareem O Adam, Akande O Ahmed, Afolayan A Mariam, Ugbomoiko U Samuel
Interaction between malaria, anaemia and malnutrition is poorly understood in asymptomatic malaria patients. This information is important in the management of malaria infection in many endemic regions in sub-Saharan Africa. Malaria parasitaemia, full blood counts and serum levels of essential micronutrients particularly iron (Fe), zinc (Zn) and copper (Cu) of the patients attending Health Centres in Ilorin, Kwara state were investigated using microscope, auto-haemanalyzer and atomic absorption spectrophotometer respectively...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29090267/perioperative-patient-blood-management-programme-multidisciplinary-recommendations-from-the-patient-blood-management-initiative-group
#7
Daniela Filipescu, Răzvan Bănăţeanu, Mircea Beuran, Traean Burcoş, Dan Corneci, Dan Cristian, Mircea Diculescu, Alina Dobrotă, Gabriela Droc, Dănuţ Isacoff, Doina Goşa, Ioana Grinţescu, Anca Lupu, Liliana Mirea, Corina Posea, Oana Stanca, Mihai Ştefan, Dana Tomescu, Cristina Tudor, Daniela Ungureanu, Gabriel Mircescu
Patients with untreated anaemia or iron deficiency who undergo surgical procedures have an increased risk for mortality and morbidity. Patient Blood Management programmes address this issue worldwide and try to improve patient outcomes through a complex set of measures targeting anaemia correction, minimisation of bleeding and improvement of anaemia tolerance, in all phases of perioperative care. The Patient Blood Management Initiative Group is a multidisciplinary team of physicians from specialties including anaesthesiology, nephrology, surgery, orthopaedics, haematology, gastroenterology and transfusion medicine...
October 2017: Rom J Anaesth Intensive Care
https://www.readbyqxmd.com/read/29076710/anaemia-and-iron-deficiency-in-pregnant-women-attending-an-antenatal-clinic-in-a-teaching-hospital-in-southern-sri-lanka
#8
D Senadheera, M Goonewardene, I Mampitiya
Introduction: In Sri Lanka the current prevalence of anaemia during pregnancy is estimated to be less than 20%. Objectives: To determine the rate of anaemia defined as hemoglobin concentration < 11 g/dl, and the rate of iron deficiency using the best cut off level of serum ferritin, in women presenting for antenatal care. Methods: Three hundred and fifty consecutive pregnant women with gestations between 12 to 20 weeks, presenting to the Academic Obstetric Unit at the Teaching Hospital Mahamodera, Galle, Sri Lanka from 10...
September 30, 2017: Ceylon Medical Journal
https://www.readbyqxmd.com/read/29070101/-methylation-status-and-mrna-expression-of-dkk-3-and-wif-1-in-acute-myeloid-leukemia-patients
#9
Meng-Meng Xu, Yan-Li Yang, Ying-Hua Geng, Jun Li, Yue Ma, Feng Zhang, Fang-Bing Zhu
OBJECTIVE: To analyze the promoter methylation status, mRNA expression and clinical significance of DKK-3 and WIF-1 genes in patients with acute myeloid leukemia(AML). METHODS: Methylation specific polymerase chain reaction (MS-PCR) mothod was carried out to detect DKK-3 and WIF-1 gene promoter methylation status in bone marrow specimen from 56 patients with AML and 20 patients with iron deficiency anaemia(IDA) as control; then the real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) was used to detect mRNA expression of DKK-3, WIF-1 gene and β -catenin in the above-mentioned specinens, and their relationship with the clinical features and survival time was analyzed...
October 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29070052/adherence-to-iron-supplements-among-women-receiving-antenatal-care-at-mulago-national-referral-hospital-uganda-cross-sectional-study
#10
Tusuubira S Kiwanuka, Sam Ononge, Paul Kiondo, Fatuma Namusoke
BACKGROUND: Antenatal iron supplementation is a cost effective way of reducing iron deficiency anaemia among pregnant women in resource limited countries like Uganda. Poor adherence to iron supplements has limited its effectiveness in reducing maternal anaemia as evidenced by the high burden of iron deficiency anemia in Sub-saharan Africa. The aim of this study was to determine the level of and factors associated with adherence to iron supplementation among women attending antenatal clinic at Mulago National Referral Hospital, Kampala, Uganda...
October 25, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29066045/medical-therapy-for-fibroids-an-overview
#11
REVIEW
Vikram Sinai Talaulikar
Uterine fibroids are the most common benign tumours in women of reproductive age group and are a cause of significant healthcare burden. Although surgical treatments have been the traditional gold standard for symptomatic uterine fibroids, several medical therapeutic approaches have been used to achieve symptom suppression in women who wish to preserve their uterus or are at elevated risk of complications during surgery. Medical therapies used for uterine fibroids include tranexamic acid, NSAIDs, contraceptive steroids, progesterone coil, GnRH analogues, aromatase inhibitors, SERMs and progesterone receptor modulators...
September 28, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29057687/safety-and-efficacy-of-intravenous-iron-administration-for-uterine-bleeding-or-postpartum-anaemia-a-narrative-review
#12
Angelos Daniilidis, Nikolaos Panteleris, Efthymia Vlachaki, Christian Breymann, Efstratios Assimakopoulos
The management of iron deficiency anaemia (IDA) consists of oral or intravenous administration of iron supplements. The aim of this narrative review is to summarise information regarding the treatment of IDA in women who have postpartum anaemia or uterine bleeding with intravenous (IV) or oral iron supplements. Fourteen randomised control studies comparing IV to oral iron treatment for IDA in 2913 women with uterine bleeding or postpartum haemorrhage are included. All reviewed studies suggest that IV iron administration is important in treating the IDA in such women and in improving their physical performance and quality of life...
October 23, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29052354/revisiting-the-ancylostoma-caninum-secretome-provides-new-information-on-hookworm-host-interactions
#13
Taylor Morante, Catherine Shepherd, Constantin Constantinoiu, Alex Loukas, Javier Sotillo
Hookworm infection is a major tropical parasitic disease affecting almost 500 million people worldwide. These soil-transmitted helminths can survive for many years in the intestine of the host, where they feed on blood, causing iron deficiency anaemia and other complications. These parasites release a variety of molecules known as excretory/secretory products (ESPs) that are involved in many different biological processes that govern parasite survival. Using a combination of separation techniques such as SDS-PAGE and OFFGEL electrophoresis, in combination with state-of-the-art mass spectrometry we have reanalysed the dog hookworm, Ancylostoma caninum, ESPs (AcES)...
October 20, 2017: Proteomics
https://www.readbyqxmd.com/read/29030368/iron-deficiency-anaemia-in-a-coeliac-a-cause-for-concern
#14
Niamh Peters, Donal Tighe
A 70-year-old woman with a 15-year history of coeliac disease was admitted for treatment and investigation of symptomatic anaemia. Of note, she was recently commenced on aspirin therapy for retinal artery occlusion. This followed a normal gastro-duodenoscopy, colonoscopy and CT abdomen as workup for iron deficiency anaemia. On this occasion, the patient was further investigated with small bowel capsule endoscopy. This revealed an ulcerated lesion in her proximal jejunum suspicious for malignancy, namely lymphoma...
October 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29019427/management-of-inflammatory-bowel-disease-related-anemia-and-iron-deficiency-with-specific-reference-to-the-role-of-intravenous-iron-in-current-practice
#15
Jürgen Stein, Ayşegül Aksan, Karima Farrag, Axel Dignass, Heinfried H Radeke
Anemia is a common extraintestinal manifestation in patients with inflammatory bowel disease, impacting disease prognosis, morbidity, hospitalization rates and time lost from work. While iron deficiency anemia and anemia of chronic inflammation predominate, combinations of hematimetric and biochemical markers facilitate the diagnosis and targeted therapy of other etiologies according to their underlying pathophysiological causes. Intravenous iron replacement is currently recommended in IBD patients with moderate to severe anemia or intolerance to oral iron...
November 5, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29016575/role-of-intravenous-ferric-carboxy-maltose-in-pregnant-women-with-iron-deficiency-anaemia
#16
Vineet Mishra, Khusaili Gandhi, Priyankur Roy, Shaheen Hokabaj, Kunur N Shah
BACKGROUND: Iron deficiency is a common nutritional deficiency amongst women of childbearing age. Peri-partum iron deficiency anaemia is associated with significant maternal, foetal and infant morbidity. Current options for treatment include oral iron, which can be ineffective and poorly tolerated, and red blood cell transfusions, which carry an inherent risk and should be avoided. Ferric carboxymaltose is a modern treatment option. The study was designed to assess the safety and efficacy of intravenous ferric carboxymaltose for correction of iron deficiency anaemia in pregnant women...
September 8, 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28981457/micronutrient-status-and-dietary-intake-of-iron-vitamin-a-iodine-folate-and-zinc-in-women-of-reproductive-age-and-pregnant-women-in-ethiopia-kenya-nigeria-and-south-africa-a-systematic-review-of-data-from-2005-to-2015
#17
REVIEW
Rajwinder Harika, Mieke Faber, Folake Samuel, Judith Kimiywe, Afework Mulugeta, Ans Eilander
A systematic review was conducted to evaluate the status and intake of iron, vitamin A, iodine, folate and zinc in women of reproductive age (WRA) (≥15-49 years) and pregnant women (PW) in Ethiopia, Kenya, Nigeria and South Africa. National and subnational data published between 2005 and 2015 were searched via Medline, Scopus and national public health websites. Per micronutrient, relevant data were pooled into an average prevalence of deficiency, weighted by sample size (WAVG). Inadequate intakes were estimated from mean (SD) intakes...
October 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28969109/prevalence-of-iron-deficiency-and-iron-deficiency-anaemia-in-adolescent-girls-in-a-tertiary-care-hospital
#18
Rekha Kumari, Raushan Kumar Bharti, Kalpana Singh, Archana Sinha, Sudhir Kumar, Anand Saran, Uday Kumar
INTRODUCTION: Iron Deficiency Anaemia (IDA) is a global health problem. It involves population of all age group and sex. But adolescent girls are more vulnerable to it. The reasons may be increased iron demand, menstrual blood loss, infection, worm infestation etc. AIM: To find the prevalence of iron deficiency and IDA in adolescent girls in a Tertiary Care Hospital. MATERIALS AND METHODS: This cross-sectional study was done in the biochemistry clinical laboratory of Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India for a period of six months (April 2015-October 2015)...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28965885/iron-supplementation-in-mouse-expands-cellular-innate-defences-in-spleen-and-defers-lethal-malaria-infection
#19
Isabel G Azcárate, Sandra Sánchez-Jaut, Patricia Marín-García, María Linares, Susana Pérez-Benavente, Marta García-Sánchez, Javier Uceda, Ali N Kamali, María-Josefa Morán-Jiménez, Antonio Puyet, Amalia Diez, José M Bautista
The co-endemicity of malnutrition, erythrocytopathies, transmissible diseases and iron-deficiency contribute to the prevalence of chronic anaemia in many populations of the developing world. Although iron dietary supplementation is applied or recommended in at risk populations, its use is controversial due to undesirable outcomes, particularly regarding the response to infections, including highly prevalent malaria. We hypothesized that a boosted oxidative stress due to iron supplementation have a similar impact on malaria to that of hereditary anaemias, enhancing innate response and conditioning tissues to prevent damage during infection...
September 29, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28960876/executive-summary-for-the-micronutrient-powders-consultation-lessons-learned-for-operational-guidance
#20
Christina Nyhus Dhillon, Danya Sarkar, Rolf Dw Klemm, Lynnette M Neufeld, Rahul Rawat, Alison Tumilowicz, Sorrel Ml Namaste
Iron deficiency anaemia is estimated to be the leading cause of years lived with disability among children. Young children's diets are often inadequate in iron and other micronutrients, and provision of essential vitamin and minerals has long been recommended. With the limited programmatic success of iron drop/syrup interventions, interest in micronutrient powders (MNP) has increased. MNP are a mixture of vitamins and minerals, enclosed in single-dose sachets, which are stirred into a child's portion of food immediately before consumption...
September 2017: Maternal & Child Nutrition
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