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Iron deficiency anaemia

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https://www.readbyqxmd.com/read/28718256/iron-deficiency-anaemia-as-risk-factor-for-simple-febrile-seizures-a-case-control-study
#1
Khawaja Tahir Aziz, Naheem Ahmed, Abdul Ghaffar Nagi
BACKGROUND: Febrile fits is common problem in children. Among other risk factors, iron deficiency anaemia is considered as aggravating factor for febrile fits. Iron deficiency anaemia is preventable and treatable disease. The objective of the study was to find out iron deficiency anaemia as risk factor for febrile fits. METHODS: It was a case control study. Thirty cases of febrile fits were recorded. Control group of 30 cases was taken at the same time with same variables but without febrile fits...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28706363/comparative-study-of-efficacy-and-safety-of-ferric-carboxymaltose-versus-iron-sucrose-in-post-partum-anaemia
#2
Nalini Sharma, J Lalnunnem Thiek, Tanie Natung, Santa Singh Ahanthem
BACKGROUND: The incidence of post-partum anaemia (PPA) is 14-24%. Treatment of PPA with injectable iron replenishes the iron store. Ferric carboxymaltose complex (FCM) is a non-dextran containing intravenous iron agent, having a very low immunogenic potential, designed to be administered in large doses in a short period of time. OBJECTIVE: To compare the efficacy and safety of intravenous FCM and iron sucrose (IS) in post-partum iron-deficiency anaemia. MATERIAL AND METHOD: In this prospective, comparative study, 120 post-partum women with iron-deficiency anaemia (Hb < 10 g%) were divided into two groups...
August 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28705055/ferrokinetics-is-associated-with-the-left-ventricular-mass-index-in-patients-with-chronic-kidney-disease
#3
Akihito Tanaka, Daijo Inaguma, Yu Watanabe, Eri Ito, Naoki Kamegai, Hiroya Shimogushi, Hibiki Shinjo, Kiyomi Koike, Yasuhiro Otsuka, Asami Takeda
Background Patients with chronic kidney disease (CKD) often have the complication of anaemia. Usage of an erythropoietin-stimulating agent accelerates iron deficiency because it promotes iron utilization. Recently, iron administration was reported to be effective for patients with cardiac failure. We examined the association between ferrokinetics and cardiac function in patients with CKD. Methods In this cross-sectional study, we examined 558 patients (424 men and 134 women; mean age, 68.9 ± 13.1 years) with CKD who were admitted to our hospital...
July 14, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28701129/iron-deficiency-and-new-insights-into-therapy
#4
Michael Sy Low, George Grigoriadis
Iron deficiency and iron deficiency anaemia remain prevalent in Australia. The groups at highest risk are pre-menopausal women, socially disadvantaged people and those of Indigenous background. Diagnosing iron deficiency using a full blood examination and iron studies can be difficult and can be further complicated by concomitant inflammation. Results of iron studies should always be interpreted as an overall picture rather than focusing on individual parameters. In difficult clinical scenarios, soluble transferrin receptor assays can be useful...
July 17, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28698743/higher-rate-of-iron-deficiency-in-obese-pregnant-sudanese-women
#5
Wisal Abbas, Ishag Adam, Duria A Rayis, Nada G Hassan, Mohamed F Lutfi
AIM: To assess the association between obesity and iron deficiency (ID). MATERIAL AND METHODS: Pregnant women were recruited from Saad Abualila Hospital, Khartoum, Sudan, during January-April 2015. Medical history (age, parity, gestational age) was gathered using questionnaire. Weight and height were measured, and body mass index (BMI) was calculated. Women were sub-grouped based on BMI into underweight (< 18.5 kg/m^2), normal weight (18.5-24.9 kg/m^2), overweight (25-29...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28695564/iron-supplementation-in-switzerland-a-bi-national-descriptive-and-observational-study
#6
Fabienne A Biétry, Balthasar Hug, Oliver Reich, Jick S Susan, Christoph Rudolf Meier
BACKGROUND: Iron deficiency is the most common nutritional disorder in the world, and it is the only common nutrient deficiency in industrialised nations. It is thought to be the most common cause of anaemia. Use of iron supplementation in Switzerland has not been previously quantified in detail. OBJECTIVES: We quantified use of iron supplementation from Swiss data and compared it with data from the UK. We assessed the frequency of serum ferritin and haemoglobin tests prior to newly started iron therapy to see whether use was based on documented low iron levels or blood parameters, especially in the case of parenteral iron supplementation...
July 11, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28695549/iron-substitution-in-the-treatment-of-chronic-heart-failure
#7
Christine Gstrein, Matthias Meyer, Pablo Anabitarte
Iron deficiency is a prevalent and clinically relevant comorbidity in up to 50% of patients with chronic heart failure (CHF). Iron deficiency in CHF patients is associated with impaired quality of life, reduced exercise capacity and increased mortality, irrespective of the presence of anaemia. It is diagnosed by determining circulating ferritin levels and transferrin saturation. Three randomised trials (CONFIRM-HF, FAIR-HF, and EFFECT-HF) of intravenous ferric carboxymaltose in the treatment of iron deficiency in CHF patients with reduced left ventricular ejection fraction demonstrated improvement of symptoms, functional capacity and quality of life...
July 11, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28684433/vacuolar-iron-transporter-tavit2-transports-fe-and-mn-and-is-effective-for-biofortification
#8
James M Connorton, Eleanor R Jones, Ildefonso Rodriguez-Ramiro, Susan Fairweather-Tait, Cristobal Uauy, Janneke Balk
Increasing the intrinsic nutritional quality of crops, known as biofortification, is viewed as a sustainable approach to alleviate micronutrient deficiencies. In particular iron deficiency anaemia is a major global health issue, but the iron content of staple crops such as wheat is difficult to change because of genetic complexity and homeostasis mechanisms. To identify target genes for biofortification of wheat (Triticum aestivum), we functionally characterized homologs of the Vacuolar Iron Transporter (VIT)...
July 6, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28679305/iatrogenic-aortic-dissection-during-percutaneous-coronary-intervention-a-case-report-and-review-of-the-literature
#9
Jia-Chen Li, Xin-Liang Guan, Ming Gong, Hong-Jia Zhang
A 64-year-old female complaining of unrelieved chest pain for 2 days was admitted to the Emergency Room of the Beijing Anzhen Hospital, Beijing, China. After definitive diagnosis, a percutaneous coronary intervention was implemented, but immediately after embedding the stent in the distal area of the right coronary artery, an acute coronary and aortic dissection was found. Cardiologists immediately gave the patient conservative management. At the same time, another smaller stent was immediately embedded in the proximal area of the right coronary artery and plunged into the ascending aorta by 2 mm, with the intention of covering the tear of the dissection...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28669237/nutritional-anemia-predominant-form-of-anemia-in-educated-young-thai-women
#10
Sirikalaya Brimson, Yaneenart Suwanwong, James M Brimson
OBJECTIVE: Anaemia is one of the most common health problems worldwide, with a high prevalence in Africa and South East Asia, including Thailand. Thai women of childbearing age have an increased risk of anaemia due to several factors including underlying health problems, lifestyles and poor diet. Therefore, we investigated the prevalence of anaemia among female students of Chulalongkorn University (aged 18-22) and categorized causes of the anaemia. DESIGN: 400 Thai female student-volunteers, without known underlying diseases were subjected to blood tests; complete blood count, Haemoglobin typing and serum ferritin level...
July 1, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28634965/the-treatment-of-iron-deficiency-without-anaemia-in-otherwise-healthy-persons
#11
German E Clénin
Iron deficiency is the most widespread and frequent nutritional disorder in the world. It affects a high proportion of children and women in developing countries and is also significantly prevalent in the industrialised world, with a clear predominance in adolescents and menstruating females. Iron is essential for optimal cognitive function and physical performance, not only as a binding site of oxygen but also as a critical constituent of many enzymes. Therefore iron deficiency at all its levels - nonanaemic iron deficiency, iron deficiency with microcytosis or hypochromia and iron deficiency anaemia - should be treated...
June 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28625177/iron-deficiency-without-anaemia-is-a-potential-cause-of-fatigue-meta-analyses-of-randomised-controlled-trials-and-cross-sectional-studies
#12
Katsuhiko Yokoi, Aki Konomi
Fe deficiency is a prevalent nutritional disease, and fatigue is a common complaint in the general and patient population. The association between Fe deficiency without anaemia (IDNA) and fatigue is unclear. Here, we performed a meta-analysis to evaluate the therapeutic effect of Fe on fatigue in patients with IDNA and the association between IDNA and fatigue in the population. Articles from the PubMed database up to 19 January 2016 were systematically searched. A total of six relevant randomised controlled trials (RCT) and six relevant cross-sectional studies were identified...
June 19, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28618058/detection-of-iron-restriction-in-anaemic-and-non-anaemic-patients-new-diagnostic-approaches
#13
Lothar Thomas, Christian Thomas
OBJECTIVE: The aim of this study was to detect iron restriction in non-anaemic patients and iron-restricted erythropoiesis (IRE) in patients with anaemia. METHOD: Haematologic indices and biochemical markers of iron deficiency (ID) were determined using the clinically accepted cut-off level for serum ferritin of ≤30 μg/l as reference of ID. To evaluate the prevalence of iron restriction and IRE in patients with higher ferritin levels we used the thresholds of the markers of ID as reference...
June 15, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28610806/heart-failure-in-patients-with-kidney-disease-and-iron-deficiency-the-role-of-iron-therapy
#14
Aleix Cases Amenós, Raquel Ojeda López, José María Portolés Pérez
Chronic kidney disease and anaemia are common in heart failure (HF) and are associated with a worse prognosis in these patients. Iron deficiency is also common in patients with HF and increases the risk of morbidity and mortality, regardless of the presence or absence of anaemia. While the treatment of anaemia with erythropoiesis-stimulating agents in patients with HF have failed to show a benefit in terms of morbidity and mortality, treatment with IV iron in patients with HF and reduced ejection fraction and iron deficiency is associated with clinical improvement...
June 10, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28608544/use-of-intravenous-iron-polymaltose-in-the-management-of-iron-deficiency-in-pregnancy-a-retrospective-cohort-study
#15
Alaa Qassim, Rosina G Gergis, Bill Jeffries, Rosalie M Grivell, Luke E Grzeskowiak
BACKGROUND: Intravenous iron polymaltose (IPM) is commonly utilised in pregnancy when oral treatment is not tolerated or where rapid replenishment of iron stores is required, but data on use in pregnancy is scarce. AIM: To examine the use, safety and efficacy of intravenous IPM in pregnancy. METHODS: Retrospective cohort study of pregnant women administered intravenous IPM between January 2014 and January 2016 at a Tertiary teaching hospital in Adelaide, Australia...
June 13, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28568906/effect-of-iron-supplementation-in-children-with-breath-holding-spells
#16
Rahul Jain, Divin Omanakuttan, Amitabh Singh, Mamta Jajoo
AIM: The aim of this study was to analyse the effect of iron supplementation in children with breath holding spells, irrespective of their iron status and study the factors associated with the response. METHODS: This was a prospective interventional study. Study population comprised of patients aged 6-36 months, attending a paediatric outpatient department with recurrent episodes (more than three in last 4 weeks) of breath holding spells. Children with loss of consciousness or convulsive movements associated with breath holding spells were considered as severe...
June 1, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28568509/investigation-and-treatment-for-iron-deficiency-in-heart-failure-the-unmet-need-in-lower-and-middle-income-countries
#17
REVIEW
Abel Makubi, David J Roberts
Frank iron deficiency has been associated with a wide range of cardiac and pulmonary abnormalities including non-ischaemic cardiomyopathy. Iron deficiency anaemia and isolated iron deficiency are well-defined adverse prognostic factors in non-ischaemic cardiac failure. Furthermore, iron-deficient patients in chronic heart failure with a serum ferritin of <100 μg/l or <300 μg/l with reduced transferrin saturation of <20%, who were given intravenous iron showed improved clinical outcomes. Iron deficiency with or without anaemia affects over a quarter of the world's population, but the impact of iron deficiency in heart failure and the effective management of iron deficiency in heart failure in Lower and Middle Income Countries (LMICs) is not well described...
June 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28566804/reticulocyte-and-erythrocyte-hypochromia-markers-in-detection-of-iron-deficiency-in-adolescent-female-athletes
#18
J Malczewska-Lenczowska, J Orysiak, B Szczepańska, D Turowski, K Burkhard-Jagodzińska, J Gajewski
The aim of this study was to analyse the effectiveness of new haematology parameters related to reticulocytes and mature red blood cells to differentiate pre latent and latent iron deficiency. The study included 219 female athletes (aged 15-20 years) representing volleyball, handball, cycling, canoeing, cross-country skiing, swimming and judo. To assess iron status the concentration of ferritin, soluble transferrin receptor (sTfR), iron and total iron binding capacity (TIBC) were determined in serum. In addition to blood morphology, the mean cellular haemoglobin content in erythrocytes (CH) and reticulocytes (CHr), mean cellular haemoglobin concentration in reticulocytes (CHCMr), the percentage of erythrocytes (HYPOm) and reticulocytes (HYPOr) with decreased cellular haemoglobin concentration, the percentage of erythrocytes (LowCHm) and reticulocytes (LowCHr) with decreased cellular haemoglobin content, and percentage of erythrocytes with decreased volume (MICROm) were determined...
June 2017: Biology of Sport
https://www.readbyqxmd.com/read/28545412/how-do-population-general-practice-and-hospital-factors-influence-ambulatory-care-sensitive-admissions-a-cross-sectional-study
#19
John Busby, Sarah Purdy, William Hollingworth
BACKGROUND: Reducing unplanned hospital admissions is a key priority within the UK and other healthcare systems, however it remains uncertain how this can be achieved. This paper explores the relationship between unplanned ambulatory care sensitive condition (ACSC) admission rates and population, general practice and hospital characteristics. Additionally, we investigated if these factors had a differential impact across 28 conditions. METHODS: We used the English Hospital Episode Statistics to calculate the number of unplanned ACSC hospital admissions for 28 conditions at 8,029 general practices during 2011/12...
May 25, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28537576/an-infant-and-mother-with-severe-b12-deficiency-vitamin-b12-status-assessment-should-be-determined-in-pregnant-women-with-anaemia
#20
A Sobczyńska-Malefora, R Ramachandran, D Cregeen, E Green, P Bennett, D J Harrington, H A Lemonde
The vitamin B12 status of infants depends on maternal B12 status during pregnancy, and during lactation if breastfed. We present a 9-month-old girl who was admitted to the metabolic unit for assessment of developmental delay. She was exclusively breastfed and the introduction of solids at 5 months was unsuccessful. Investigations revealed pancytopenia, undetectable B12 and highly elevated methylmalonic acid and homocysteine. Methylmalonic acid and homocysteine normalised following B12 injections. Marked catch-up of developmental milestones was noted after treatment with B12...
May 24, 2017: European Journal of Clinical Nutrition
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