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JOURNAL ARTICLE
Daniel Schiltz, Sophia Theresa Diesch, Natalie Kiermeier, Dominik Eibl, Gunther Felmerer, Stephan Schreml, Niklas Biermann, Lukas Prantl, Christian D Taeger
INTRODUCTION: Exact quantification of volumetric changes of the extremities is difficult and often error prone. The aim of this study was to establish a standardized method based on 3D scans. Furthermore, this study tests the method in terms of reproducibility and evaluates volume changes after surgical therapy in patients suffering from lymphedema on the lower extremity. METHODS: 3D-scans of the lower limb were performed with a mobile 3D-scanner. "repeatability" and "inter-observer reliability" of digital volumetry were tested...
April 3, 2024: Annals of Vascular Surgery
#2
JOURNAL ARTICLE
David Schult, H Carlo Maurer, Marina Frolova, Marc Ringelhan, Ulrich Mayr, Jörg Ulrich, Markus Heilmaier, Sebastian Rasch, Tobias Lahmer, Sandra Reitmeier, Chiara Hennig, Christina Gassner, Niklas Thur, Theresa Will, Klaus-Peter Janssen, Katja Steiger, Moritz Jesinghaus, Klaus Neuhaus, Michael Quante, Dirk Haller, Mohamed Abdelhafez, Roland M Schmid, Moritz Middelhoff
INTRODUCTION: The identification of risk factors for precursor lesions of colorectal cancer (CRC) holds great promise in the context of prevention. With the current study we aimed to identify patient characteristics associated with colorectal polyps (CP) and polyp features of potential malignant progression. Furthermore, a potential association with gut microbiota in this context was investigated. METHODS: In this single center study, a total of 162 patients with colorectal polyps and 91 control patients were included...
December 13, 2023: Clinical and Translational Gastroenterology
#3
JOURNAL ARTICLE
Niklas Grassl, Katharina Sahm, Heike Süße, Isabel Poschke, Lukas Bunse, Theresa Bunse, Tamara Boschert, Iris Mildenberger, Anne-Kathleen Rupp, Max Philipp Ewinger, Lisa-Marie Lanz, Monika Denk, Ghazaleh Tabatabai, Michael W Ronellenfitsch, Ulrich Herrlinger, Martin Glas, Dietmar Krex, Peter Vajkoczy, Antje Wick, Inga Harting, Felix Sahm, Andreas von Deimling, Martin Bendszus, Wolfgang Wick, Michael Platten
INTRODUCTION: Diffuse midline gliomas (DMG) are universally lethal central nervous system tumors that carry almost unanimously the clonal driver mutation histone-3 K27M (H3K27M). The single amino acid substitution of lysine to methionine harbors a neoantigen that is presented in tumor tissue. The long peptide vaccine H3K27M-vac targeting this major histocompatibility complex class II (MHC class II)-restricted neoantigen induces mutation-specific immune responses that suppress the growth of H3K27M+ flank tumors in an MHC-humanized rodent model...
October 19, 2023: Neurological research and practice
#4
JOURNAL ARTICLE
Tobias Jagomast, Theresa Mohr, Paul Niklas Axt, Kai Mortensen, Folke Brinkmann, Markus Weckmann, Gordon Ring, Michael Reppel, Daniel Drömann, Klaas F Franzen
Cardiovascular health at a young age has implications for preventing cardiovascular disease, and it is associated with improved physical and cognitive performance during the aging process. Sports are well known to prevent cardiovascular disease; however, school-based interventions have mostly been neglected. This cross-sectional study aimed to compare groups of high school students, stratified by the amount of physical activity in their high school curriculum and downtime. Comparisons concerning physical and cognitive performance and arterial stiffness were made...
July 24, 2023: Journal of Functional Morphology and Kinesiology
#5
JOURNAL ARTICLE
David Niklas Springer, Marianna Traugott, Elisabeth Reuberger, Klaus Benjamin Kothbauer, Christian Borsodi, Michelle Nägeli, Theresa Oelschlägel, Hasan Kelani, Oliver Lammel, Josef Deutsch, Elisabeth Puchhammer-Stöckl, Eva Höltl, Judith Helene Aberle, Karin Stiasny, Lukas Weseslindtner
Primary infection with the Omicron variant of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) can be serologically identified with distinct profiles of neutralizing antibodies (nAbs), as indicated by high titers against the Omicron variant and low titers against the ancestral wild-type (WT). Here, we evaluated whether a novel surrogate virus neutralization assay (sVNT) that simultaneously quantifies the binding inhibition of angiotensin-converting enzyme 2 (ACE2) to the proteins of the WT- and Omicron-specific receptor-binding domains (RBDs) can identify nAb profiles after primary Omicron infection with accuracy similar to that of variant-specific live-virus neutralization tests (NTs)...
July 5, 2023: Diagnostics
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RANDOMIZED CONTROLLED TRIAL
Glenn Eastwood, Alistair D Nichol, Carol Hodgson, Rachael L Parke, Shay McGuinness, Niklas Nielsen, Stephen Bernard, Markus B Skrifvars, Dion Stub, Fabio S Taccone, John Archer, Demetrios Kutsogiannis, Josef Dankiewicz, Gisela Lilja, Tobias Cronberg, Hans Kirkegaard, Gilles Capellier, Giovanni Landoni, Janneke Horn, Theresa Olasveengen, Yaseen Arabi, Yew Woon Chia, Andrej Markota, Matthias Hænggi, Matt P Wise, Anders M Grejs, Steffen Christensen, Heidi Munk-Andersen, Asger Granfeldt, Geir Ø Andersen, Eirik Qvigstad, Arnljot Flaa, Matthew Thomas, Katie Sweet, Jeremy Bewley, Minna Bäcklund, Marjaana Tiainen, Manuela Iten, Anja Levis, Leah Peck, James Walsham, Adam Deane, Angajendra Ghosh, Filippo Annoni, Yan Chen, David Knight, Eden Lesona, Haytham Tlayjeh, Franc Svenšek, Peter J McGuigan, Jade Cole, David Pogson, Matthias P Hilty, Joachim P Düring, Michael J Bailey, Eldho Paul, Bridget Ady, Kate Ainscough, Anna Hunt, Sinéad Monahan, Tony Trapani, Ciara Fahey, Rinaldo Bellomo
BACKGROUND: Guidelines recommend normocapnia for adults with coma who are resuscitated after out-of-hospital cardiac arrest. However, mild hypercapnia increases cerebral blood flow and may improve neurologic outcomes. METHODS: We randomly assigned adults with coma who had been resuscitated after out-of-hospital cardiac arrest of presumed cardiac or unknown cause and admitted to the intensive care unit (ICU) in a 1:1 ratio to either 24 hours of mild hypercapnia (target partial pressure of arterial carbon dioxide [Paco2 ], 50 to 55 mm Hg) or normocapnia (target Paco2 , 35 to 45 mm Hg)...
July 6, 2023: New England Journal of Medicine
#7
JOURNAL ARTICLE
Svenja Belkin, Julia Benthien, Paul Niklas Axt, Theresa Mohr, Kai Mortensen, Markus Weckmann, Daniel Drömann, Klaas Frederik Franzen
In addition to the market launch of heated tobacco products (HTPs) and the JUUL as well as the EVALI, they caused a widespread discussion on the risk reduction compared to a combustible cigarette. Furthermore, first data showed harmful effects on the cardiovascular system. We, therefore, conducted investigations including a control group with a nicotine-free liquid. Forty active smokers were studied in two different approaches during and after consuming an HTP, a cigarette, a JUUL, or a typical electronic cigarette with or without nicotine in a partly double-blinded randomised, cross-over trial...
May 29, 2023: International Journal of Molecular Sciences
#8
JOURNAL ARTICLE
Laura Töbelmann, Inge Hahne, Theresa Schulze, Niklas Bergmann, Lukas Fuchs, Marco Zierhut, Eric Hahn, Kerem Böge
BACKGROUND: Research exploring the effects of yoga therapy (YT) on individuals with schizophrenia spectrum disorders (SSD) is scarce. Therefore, the current study aimed to explore possible mechanisms of actions and processes, as well as adverse effects of a novel yoga-based group intervention (YoGI) for in-patients with SSD in a German university hospital setting. MATERIAL AND METHODS: A longitudinal qualitative study was integrated into a rater-blinded randomized controlled trial, exploring the impact of a 4-week YoGI as add-on treatment...
2023: Frontiers in Psychiatry
#9
JOURNAL ARTICLE
Tobias Boeselt, Johannes Kroenig, Theresa-Sophie Lueders, Niklas Koehler, Bjoern Beutel, Olaf Hildebrandt, Ulrich Koehler, Regina Conradt
INTRODUCTION: In clinical practice, wheezing and coughing represent a worsening of the respiratory situation of COPD patients and should be monitored long-term during and after an Acute Exacerbation of COPD (AECOPD) to observe the therapy. We investigated if overnight monitoring of wheezing and coughing is feasible during AECOPD and whether automatic long - term monitoring enables an objective assessment during and after an AECOPD. METHODS: In 14 patients (age: 56-80 years) with pre-existing COPD (stages B-D) nighttime wheezing and coughing events were monitored for a period of three weeks...
2022: International Journal of Chronic Obstructive Pulmonary Disease
#10
JOURNAL ARTICLE
Kevin Hai-Ning Lu, Julius Michel, Michael Kilian, Katrin Aslan, Hao Qi, Niklas Kehl, Stefanie Jung, Khwab Sanghvi, Katharina Lindner, Xin-Wen Zhang, Edward W Green, Isabel Poschke, Miriam Ratliff, Theresa Bunse, Felix Sahm, Andreas von Deimling, Wolfgang Wick, Michael Platten, Lukas Bunse
Background: Glioblastoma (GBM) is characterized by low numbers of glioma-infiltrating lymphocytes (GIL) with a dysfunctional phenotype. Whether this dysfunctional phenotype is fixed or can be reversed upon ex vivo culturing is poorly understood. The aim of this study was to assess T cell receptor (TCR)-dynamics and -specificities as well as determinants of in vitro GIL expansion by sequencing-based technologies and functional assays to explore the use of GIL for cell therapy. Methods: By means of flow cytometry, T cell functionality in GIL cultures was assessed from 9 GBM patients...
January 2022: Neuro-oncology advances
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JOURNAL ARTICLE
Elisa F Brandt, Maike Baues, Theresa H Wirtz, Jan-Niklas May, Petra Fischer, Anika Beckers, Björn-Carsten Schüre, Hacer Sahin, Christian Trautwein, Twan Lammers, Marie-Luise Berres
Hepatocellular carcinoma (HCC) constitutes a devastating health burden. Recently, tumor microenvironment-directed interventions have profoundly changed the landscape of HCC therapy. In the present study, the function of the chemokine CXCL10 during fibrosis-associated hepatocarcinogenesis was analyzed with specific focus on its impact in shaping the tumor microenvironment. C57BL/6J wild type (WT) and Cxcl10 knockout mice ( Cxcl10 -/- ) were treated with diethylnitrosamine (DEN) and tetrachloromethane (CCl4 ) to induce fibrosis-associated HCCs...
July 23, 2022: International Journal of Molecular Sciences
#12
JOURNAL ARTICLE
Manuel Neuberger, Janina Skladny, Nora Goly, Frederik Wessels, Christel WEIß, Luisa Egen, Philipp Erben, Matthias GROß-Weege, Britta Grüne, Friedrich Hartung, Jonas Herrmann, Patrick Honeck, Jonas Jarczyk, Karl-Friedrich Kowalewski, Julia Mühlbauer, Katja Nitschke, Malin Nientiedt, Margarete Theresa Walach, Frank Waldbillig, Niklas Westhoff, Jost VON Hardenberg, Maximilian Kriegmair, Thomas S Worst, Philipp Nuhn
BACKGROUND/AIM: To assess the baseline inflammatory markers modified Glasgow Prognostic Score (mGPS), systemic immune-inflammation index (SII), and neutrophile-to-lymphocyte ratio (NLR) as pragmatic tools for predicting response to chemohormonal therapy (docetaxel plus ADT) and prognosis in men with metastatic hormone-sensitive prostate cancer (mHSPC). PATIENTS AND METHODS: Male patients who received docetaxel at a tertiary university care center between 2014 and 2019 were screened for completion of 6 cycles...
April 2022: Anticancer Research
#13
JOURNAL ARTICLE
Theresa Schulze, Eric Hahn, Inge Hahne, Niklas Bergmann, Lukas Marian Fuchs, Franziska Mähler, Marco Matthäus Zierhut, Thi Minh Tam Ta, Gerdina Hendrika Maria Pijnenborg, Kerem Böge
Background: Yoga may pose a promising complementary therapy in the multimodal treatment of in-patients with schizophrenia spectrum disorders (SSD). However, to date, no studies have qualitatively examined in-patients' with SSD experiences of Yoga as well as their perceptions of its limitations and benefits as a treatment component. This qualitative study aimed to explore for the first time the mechanisms and processes of Yoga-based Group Intervention (YoGI) for in-patients with SSD in Germany by asking for their subjective experiences...
2021: Frontiers in Psychiatry
#14
JOURNAL ARTICLE
Theresa Vilsmaier, Niklas Amann, Sanja Löb, Elisa Schmoeckel, Christina Kuhn, Alaleh Zati Zehni, Sarah Meister, Susanne Beyer, Theresa M Kolben, Johanna Becker, Jan-Niclas Mumm, Sven Mahner, Udo Jeschke, Thomas Kolben
BACKGROUND: Maternal immunological rejection of the semi-allogenic fetus is discussed as one of the significant factors involved in early pregnancy loss. An array of cytokines secreted by both maternal and fetal cells is involved in generating a delicate maternal immune tolerance. Interleukin-7 (IL-7) is discussed to play a key role in pro-inflammatory processes, but there is still limited insight into the pathophysiological input on placentation and embryonic development in early pregnancy loss...
September 2021: American Journal of Reproductive Immunology: AJRI
#15
JOURNAL ARTICLE
Sanja Löb, Niklas Amann, Christina Kuhn, Elisa Schmoeckel, Achim Wöckel, Alaleh Zati Zehni, Till Kaltofen, Simon Keckstein, Jan-Niclas Mumm, Sarah Meister, Thomas Kolben, Sven Mahner, Udo Jeschke, Theresa Vilsmaier
BACKGROUND: Pregnancy is an extraordinarily complex immunological process. For successful pregnancy maintenance the maternal immune system must adapt to and tolerate the semi-allogenic fetus at the fetomaternal interface of the placenta. This balance is regulated by cytokines with a predominant T helper 2 (Th-2) system and a suppressed inflammatory T helper 1 (Th-1) response. This study investigates the role of the Th-1 pro-inflammatory cytokine Interleukin-1 beta (IL-1β) and its role in early pregnancy loss...
April 2021: Journal of Reproductive Immunology
#16
JOURNAL ARTICLE
Robin Simsa, Theresa Rothenbücher, Hakan Gürbüz, Nidal Ghosheh, Jenny Emneus, Lachmi Jenndahl, David L Kaplan, Niklas Bergh, Alberto Martinez Serrano, Per Fogelstrand
Human brain tissue models such as cerebral organoids are essential tools for developmental and biomedical research. Current methods to generate cerebral organoids often utilize Matrigel as an external scaffold to provide structure and biologically relevant signals. Matrigel however is a nonspecific hydrogel of mouse tumor origin and does not represent the complexity of the brain protein environment. In this study, we investigated the application of a decellularized adult porcine brain extracellular matrix (B-ECM) which could be processed into a hydrogel (B-ECM hydrogel) to be used as a scaffold for human embryonic stem cell (hESC)-derived brain organoids...
2021: PloS One
#17
JOURNAL ARTICLE
Simon Keckstein, Sophia Pritz, Niklas Amann, Sarah Meister, Susanne Beyer, Magdalena Jegen, Christina Kuhn, Stefan Hutter, Julia Knabl, Sven Mahner, Thomas Kolben, Udo Jeschke, Theresa M Kolben
Gestational diabetes mellitus (GDM) is known to increase the risk for feto-maternal complications during pregnancy. A state of low-grade inflammation, with elevated levels of proinflammatory molecules, similar to patients with obesity or diabetes mellitus type 2 has also been partly described in GDM. The placenta, as unique interface between mother and fetus, is not only passively affected by changes in one of these organisms, but also acts as a modulator by expressing hormones and cytokines. This study aimed to investigate the expression of the proinflammatory cytokines Interleukin (IL) 7, 8 and 15 in GDM in placental tissue...
October 28, 2020: International Journal of Molecular Sciences
#18
JOURNAL ARTICLE
Theresa Küting, Niklas Beier, Michael Krämer, Burkhard Madea
γ-Hydroxybutyric acid (GHB) and its corresponding lactone γ-butyrolactone (GBL) are misused as knock out (k.o.) drugs. The short detection window and the major inter- and intra-individual variations of endogenous GHB concentrations in commonly used matrices such as blood and urine complicate the analytical proof of an exogenous GHB/GBL administration. We searched for an alternative way to prove an exogenous GHB/GBL administration via detection of methyl- and ethyl-4-hydroxybutyrate, which could arise in alcoholic solutions after spiking with GHB/GBL...
December 12, 2020: Journal of Analytical Toxicology
#19
JOURNAL ARTICLE
Stefanie Theresa Jost, Anna Sauerbier, Veerle Visser-Vandewalle, Keyoumars Ashkan, Monty Silverdale, Julian Evans, Philipp A Loehrer, Alexandra Rizos, Jan Niklas Petry-Schmelzer, Paul Reker, Gereon Rudolf Fink, Jeremy Franklin, Michael Samuel, Alfons Schnitzler, Michael Thomas Barbe, Angelo Antonini, Pablo Martinez-Martin, Lars Timmermann, K Ray-Chaudhuri, Haidar S Dafsari
OBJECTIVE: To examine 36-month effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on non-motor symptoms (NMS) compared with standard-of-care medical treatment (MED) in Parkinson's disease (PD). METHODS: Here we report the 36-month follow-up of a prospective, observational, controlled, international multicentre study of the NILS cohort. Assessments included NMSScale (NMSS), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD)...
May 5, 2020: Journal of Neurology, Neurosurgery, and Psychiatry
#20
JOURNAL ARTICLE
Katarina Wilhelmson, Isabelle Andersson Hammar, Anna Ehrenberg, Johan Niklasson, Jeanette Eckerblad, Niklas Ekerstad, Theresa Westgård, Eva Holmgren, N David Åberg, Synneve Dahlin Ivanoff
The aim of the study is to evaluate the effects of the Comprehensive Geriatric Assessment (CGA) for frail older people in Swedish acute hospital settings - the CGA-Swed study. In this study protocol, we present the study design, the intervention and the outcome measures as well as the baseline characteristics of the study participants. The study is a randomised controlled trial with an intervention group receiving the CGA and a control group receiving medical assessment without the CGA. Follow-ups were conducted after 1, 6 and 12 months, with dependence in activities of daily living (ADL) as the primary outcome measure...
January 24, 2020: Geriatrics
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