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William S Harris

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https://www.readbyqxmd.com/read/28199314/whole-genome-landscape-of-pancreatic-neuroendocrine-tumours
#1
Aldo Scarpa, David K Chang, Katia Nones, Vincenzo Corbo, Ann-Marie Patch, Peter Bailey, Rita T Lawlor, Amber L Johns, David K Miller, Andrea Mafficini, Borislav Rusev, Maria Scardoni, Davide Antonello, Stefano Barbi, Katarzyna O Sikora, Sara Cingarlini, Caterina Vicentini, Skye McKay, Michael C J Quinn, Timothy J C Bruxner, Angelika N Christ, Ivon Harliwong, Senel Idrisoglu, Suzanne McLean, Craig Nourse, Ehsan Nourbakhsh, Peter J Wilson, Matthew J Anderson, J Lynn Fink, Felicity Newell, Nick Waddell, Oliver Holmes, Stephen H Kazakoff, Conrad Leonard, Scott Wood, Qinying Xu, Shivashankar Hiriyur Nagaraj, Eliana Amato, Irene Dalai, Samantha Bersani, Ivana Cataldo, Angelo P Dei Tos, Paola Capelli, Maria Vittoria Davì, Luca Landoni, Anna Malpaga, Marco Miotto, Vicki L J Whitehall, Barbara A Leggett, Janelle L Harris, Jonathan Harris, Marc D Jones, Jeremy Humphris, Lorraine A Chantrill, Venessa Chin, Adnan M Nagrial, Marina Pajic, Christopher J Scarlett, Andreia Pinho, Ilse Rooman, Christopher Toon, Jianmin Wu, Mark Pinese, Mark Cowley, Andrew Barbour, Amanda Mawson, Emily S Humphrey, Emily K Colvin, Angela Chou, Jessica A Lovell, Nigel B Jamieson, Fraser Duthie, Marie-Claude Gingras, William E Fisher, Rebecca A Dagg, Loretta M S Lau, Michael Lee, Hilda A Pickett, Roger R Reddel, Jaswinder S Samra, James G Kench, Neil D Merrett, Krishna Epari, Nam Q Nguyen, Nikolajs Zeps, Massimo Falconi, Michele Simbolo, Giovanni Butturini, George Van Buren, Stefano Partelli, Matteo Fassan, Kum Kum Khanna, Anthony J Gill, David A Wheeler, Richard A Gibbs, Elizabeth A Musgrove, Claudio Bassi, Giampaolo Tortora, Paolo Pederzoli, John V Pearson, Nicola Waddell, Andrew V Biankin, Sean M Grimmond
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to more sensitive detection methods, and this increase is creating challenges for clinical management. We performed whole-genome sequencing of 102 primary PanNETs and defined the genomic events that characterize their pathogenesis. Here we describe the mutational signatures they harbour, including a deficiency in G:C > T:A base excision repair due to inactivation of MUTYH, which encodes a DNA glycosylase. Clinically sporadic PanNETs contain a larger-than-expected proportion of germline mutations, including previously unreported mutations in the DNA repair genes MUTYH, CHEK2 and BRCA2...
February 15, 2017: Nature
https://www.readbyqxmd.com/read/28198164/influence-of-maternal-and-socioeconomic-factors-on-breast-milk-fatty-acid-composition-in-urban-low-income-families
#2
Uma Nayak, Suman Kanungo, Dadong Zhang, E Ross Colgate, Marya P Carmolli, Ayan Dey, Masud Alam, Byomkesh Manna, Ranjan Kumar Nandy, Deok Ryun Kim, Dilip Kumar Paul, Saugato Choudhury, Sushama Sahoo, William S Harris, Thomas F Wierzba, Tahmeed Ahmed, Beth D Kirkpatrick, Rashidul Haque, William A Petri, Josyf C Mychaleckyj
The lipid composition of breast milk may have a significant impact on early infant growth and cognitive development. Comprehensive breast milk data is lacking from low-income populations in the Indian subcontinent impeding assessment of deficiencies and limiting development of maternal nutritional interventions. A single breast milk specimen was collected within 6 weeks postpartum from two low-income maternal cohorts of exclusively breastfed infants, from Dhaka, Bangladesh (n = 683) and Kolkata, India (n = 372) and assayed for percentage composition of 26 fatty acids...
February 15, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28194439/an-early-biomarker-algorithm-predicts-lethal-graft-versus-host-disease-and-survival
#3
Matthew J Hartwell, Umut Özbek, Ernst Holler, Anne S Renteria, Hannah Major-Monfried, Pavan Reddy, Mina Aziz, William J Hogan, Francis Ayuk, Yvonne A Efebera, Elizabeth O Hexner, Udomsak Bunworasate, Muna Qayed, Rainer Ordemann, Matthias Wölfl, Stephan Mielke, Attaphol Pawarode, Yi-Bin Chen, Steven Devine, Andrew C Harris, Madan Jagasia, Carrie L Kitko, Mark R Litzow, Nicolaus Kröger, Franco Locatelli, George Morales, Ryotaro Nakamura, Ran Reshef, Wolf Rösler, Daniela Weber, Kitsada Wudhikarn, Gregory A Yanik, John E Levine, James L M Ferrara
BACKGROUND. No laboratory test can predict the risk of nonrelapse mortality (NRM) or severe graft-versus-host disease (GVHD) after hematopoietic cellular transplantation (HCT) prior to the onset of GVHD symptoms. METHODS. Patient blood samples on day 7 after HCT were obtained from a multicenter set of 1,287 patients, and 620 samples were assigned to a training set. We measured the concentrations of 4 GVHD biomarkers (ST2, REG3α, TNFR1, and IL-2Rα) and used them to model 6-month NRM using rigorous cross-validation strategies to identify the best algorithm that defined 2 distinct risk groups...
February 9, 2017: JCI Insight
https://www.readbyqxmd.com/read/28192521/acquired-resistance-to-oxaliplatin-is-not-directly-associated-with-increased-resistance-to-dna-damage-in-sk-n-asroxali4000-a-newly-established-oxaliplatin-resistant-sub-line-of-the-neuroblastoma-cell-line-sk-n-as
#4
Emily Saintas, Liam Abrahams, Gulshan T Ahmad, Anu-Oluwa M Ajakaiye, Abdulaziz S H A M AlHumaidi, Candice Ashmore-Harris, Iain Clark, Usha K Dura, Carine N Fixmer, Chinedu Ike-Morris, Mireia Mato Prado, Danielle Mccullough, Shishir Mishra, Katia M U Schöler, Husne Timur, Maxwell D C Williamson, Markella Alatsatianos, Basma Bahsoun, Edith Blackburn, Catherine E Hogwood, Pamela E Lithgow, Michelle Rowe, Lyto Yiangou, Florian Rothweiler, Jindrich Cinatl, Richard Zehner, Anthony J Baines, Michelle D Garrett, Campbell W Gourlay, Darren K Griffin, William J Gullick, Emma Hargreaves, Mark J Howard, Daniel R Lloyd, Jeremy S Rossman, C Mark Smales, Anastasios D Tsaousis, Tobias von der Haar, Mark N Wass, Martin Michaelis
The formation of acquired drug resistance is a major reason for the failure of anti-cancer therapies after initial response. Here, we introduce a novel model of acquired oxaliplatin resistance, a sub-line of the non-MYCN-amplified neuroblastoma cell line SK-N-AS that was adapted to growth in the presence of 4000 ng/mL oxaliplatin (SK-N-ASrOXALI4000). SK-N-ASrOXALI4000 cells displayed enhanced chromosomal aberrations compared to SK-N-AS, as indicated by 24-chromosome fluorescence in situ hybridisation. Moreover, SK-N-ASrOXALI4000 cells were resistant not only to oxaliplatin but also to the two other commonly used anti-cancer platinum agents cisplatin and carboplatin...
2017: PloS One
https://www.readbyqxmd.com/read/28179898/metatranscriptomic-analysis-reveals-unexpectedly-diverse-microbial-metabolism-in-a-biogeochemical-hot-spot-in-an-alluvial-aquifer
#5
Talia N M Jewell, Ulas Karaoz, Markus Bill, Romy Chakraborty, Eoin L Brodie, Kenneth H Williams, Harry R Beller
Organic matter deposits in alluvial aquifers have been shown to result in the formation of naturally reduced zones (NRZs), which can modulate aquifer redox status and influence the speciation and mobility of metals, affecting groundwater geochemistry. In this study, we sought to better understand how natural organic matter fuels microbial communities within anoxic biogeochemical hot spots (NRZs) in a shallow alluvial aquifer at the Rifle (CO) site. We conducted a 20-day microcosm experiment in which NRZ sediments, which were enriched in buried woody plant material, served as the sole source of electron donors and microorganisms...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28166215/genetic-loci-associated-with-chronic-obstructive-pulmonary-disease-overlap-with-loci-for-lung-function-and-pulmonary-fibrosis
#6
Brian D Hobbs, Kim de Jong, Maxime Lamontagne, Yohan Bossé, Nick Shrine, María Soler Artigas, Louise V Wain, Ian P Hall, Victoria E Jackson, Annah B Wyss, Stephanie J London, Kari E North, Nora Franceschini, David P Strachan, Terri H Beaty, John E Hokanson, James D Crapo, Peter J Castaldi, Robert P Chase, Traci M Bartz, Susan R Heckbert, Bruce M Psaty, Sina A Gharib, Pieter Zanen, Jan W Lammers, Matthijs Oudkerk, H J Groen, Nicholas Locantore, Ruth Tal-Singer, Stephen I Rennard, Jørgen Vestbo, Wim Timens, Peter D Paré, Jeanne C Latourelle, Josée Dupuis, George T O'Connor, Jemma B Wilk, Woo Jin Kim, Mi Kyeong Lee, Yeon-Mok Oh, Judith M Vonk, Harry J de Koning, Shuguang Leng, Steven A Belinsky, Yohannes Tesfaigzi, Ani Manichaikul, Xin-Qun Wang, Stephen S Rich, R Graham Barr, David Sparrow, Augusto A Litonjua, Per Bakke, Amund Gulsvik, Lies Lahousse, Guy G Brusselle, Bruno H Stricker, André G Uitterlinden, Elizabeth J Ampleford, Eugene R Bleecker, Prescott G Woodruff, Deborah A Meyers, Dandi Qiao, David A Lomas, Jae-Joon Yim, Deog Kyeom Kim, Iwona Hawrylkiewicz, Pawel Sliwinski, Megan Hardin, Tasha E Fingerlin, David A Schwartz, Dirkje S Postma, William MacNee, Martin D Tobin, Edwin K Silverman, H Marike Boezen, Michael H Cho
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10(-6)) in 9,498 cases and 9,748 controls. In the combined meta-analysis, we identified 22 loci associated at genome-wide significance, including 13 new associations with COPD. Nine of these 13 loci have been associated with lung function in general population samples, while 4 (EEFSEC, DSP, MTCL1, and SFTPD) are new...
February 6, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28161760/incidence-survival-pathology-and-genetics-of-adult-latino-americans-with-glioblastoma
#7
Maryam Shabihkhani, Donatello Telesca, Masoud Movassaghi, Yalda B Naeini, Kourosh M Naeini, Seyed Amin Hojat, Diviya Gupta, Gregory M Lucey, Michael Ontiveros, Michael W Wang, Lauren S Hanna, Desiree E Sanchez, Sergey Mareninov, Negar Khanlou, Harry V Vinters, Marvin Bergsneider, Phioanh Leia Nghiemphu, Albert Lai, Linda M Liau, Timothy F Cloughesy, William H Yong
: Latino Americans are a rapidly growing ethnic group in the United States but studies of glioblastoma in this population are limited. We have evaluated characteristics of 21,184 glioblastoma patients from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. This SEER data from 2001 to 2011 draws from 28% of the U.S. POPULATION: Latinos have a lower incidence of GBM and present slightly younger than non-Latino Whites. Cubans present at an older age than other Latino sub-populations...
February 4, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28156635/randomized-trial-of-inpatient-palliative-care-in-patients-hospitalized-for-hematopoietic-stem-cell-transplantation-hct
#8
Thomas William LeBlanc, Harry VanDusen, Lara Traeger, Joseph A Greer, William F Pirl, Vicki A Jackson, Jason Telles, Alison Rhodes, Yi-Bin Albert Chen, Jennifer S Temel
: 103 Background: During HCT, patients experience physical and psychological symptoms that negatively impact their quality of life (QOL). We assessed the impact of an inpatient palliative care intervention on patient QOL, symptom burden, and mood during HCT hospitalization and at 3 months post-HCT. METHODS: We randomized 160 patients with hematologic malignancies admitted for autologous or allogeneic HCT to an inpatient palliative care intervention (n=81) integrated with transplant care compared to transplant care alone (n=79)...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156634/randomized-trial-of-early-integrated-palliative-and-oncology-care
#9
Areej El-Jawahri, William F Pirl, Vicki A Jackson, Elyse R Park, Anthony Back, Alona Muzikansky, Mihir Kamdar, Simone Rinaldi, Juliet Jacobsen, Emily R Gallagher, Joel Fishbein, Justin Eusebio, Harry VanDusen, Jennifer S Temel
: 104 Background: Early palliative care (PC) improves outcomes in patients with newly diagnosed metastatic non-small cell lung cancer (NSCLC) and in patients identified by clinicians as having poor prognosis, advanced cancer. We evaluated the impact of early, integrated palliative and oncology care in patients with newly diagnosed lung and gastrointestinal (GI) cancer. METHODS: Between 5/2/11 and 7/20/15, we randomly assigned patients with newly diagnosed incurable lung (NSCLC, small cell, mesothelioma) or GI (pancreas, hepatobiliary, gastric, esophageal) cancer to PC integrated with oncology care (monthly visits with PC) or usual oncology care...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156551/effect-of-early-integrated-palliative-care-on-family-caregivers-fc-outcomes-for-patients-with-gastrointestinal-and-lung-cancer
#10
Vicki A Jackson, Joseph A Greer, William F Pirl, Elyse R Park, Anthony Back, Alona Muzikansky, Mihir Kamdar, Simone Rinaldi, Juliet Jacobsen, Joel Fishbein, Justin Eusebio, Harry VanDusen, Ryan David Nipp, David P Ryan, Jennifer S Temel
: 234 Background: Patients with newly diagnosed advanced cancers who receive early palliative care (PC) integrated with oncology care report improvement in their quality of life (QOL) and mood. While a telephone-based psycho-educational intervention for FC decrease depression, the impact of early, integrated outpatient PC models on FC outcomes remains unknown. METHODS: We conducted a randomized trial of early PC integrated with oncology care versus oncology care alone for newly diagnosed patients with incurable lung and gastrointestinal cancers and their FC...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156457/symptom-burden-to-predict-health-care-utilization-in-hospitalized-patients-with-incurable-cancer
#11
Areej El-Jawahri, Samantha M C Moran, Sara D'Arpino, Connor Johnson, Daniel E Lage, Risa Wong, Yian Xiao, Harry VanDusen, William F Pirl, Lara Traeger, Inga Tolin Lennes, Barbara J Cashavelly, Holly S Martinson, Vicki A Jackson, Joseph A Greer, David P Ryan, Ephraim P Hochberg, Jennifer S Temel
: 98 Background: Patients with incurable cancer are often hospitalized and have frequent readmissions after discharge. Considering the high physical and psychological symptom burden in this population, we sought to investigate symptoms as predictors of hospital length of stay (LOS) and time to first unplanned readmission. METHODS: We consecutively enrolled incurable cancer patients with unplanned hospital admissions from 9/2014-4/2016. Within the first 5 days of admission, we assessed physical (Edmonton Symptom Assessment System [ESAS]; scored 0-10) and mood symptoms (Patient Health Questionnaire 4 [PHQ-4]; scored categorically)...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28146342/measuring-the-impact-of-the-pet-trade-on-indonesian-birds
#12
J Berton C Harris, Morgan W Tingley, Fangyuan Hua, Ding Li Yong, J Marion Adeney, Tien Ming Lee, William Marthy, Dewi M Prawiradilaga, Cagan H Sekercioglu, Suyadi, Nurul Winarni, David S Wilcove
The trade in wild animals involves one-third of the world's bird species and thousands of other vertebrate species. Although a few species are imperiled as a result of the wildlife trade, the lack of field studies makes it difficult to gauge how serious a threat it is to biodiversity. We used data on changes in bird abundances across space and time and information from trapper interviews to evaluate the effects of trapping wild birds for the pet trade in Sumatra, Indonesia. To analyze changes in bird abundance over time, we used data gathered over 14 years of repeated bird surveys in a 900-ha forest in southern Sumatra...
March 31, 2016: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28128610/search-for-dark-matter-and-supersymmetry-with-a-compressed-mass-spectrum-in-the-vector-boson-fusion-topology-in-proton-proton-collisions-at-sqrt-s-8%C3%A2-%C3%A2-tev
#13
V Khachatryan, A M Sirunyan, A Tumasyan, W Adam, E Asilar, T Bergauer, J Brandstetter, E Brondolin, M Dragicevic, J Erö, M Flechl, M Friedl, R Frühwirth, V M Ghete, C Hartl, N Hörmann, J Hrubec, M Jeitler, A König, I Krätschmer, D Liko, T Matsushita, I Mikulec, D Rabady, N Rad, B Rahbaran, H Rohringer, J Schieck, J Strauss, W Treberer-Treberspurg, W Waltenberger, C-E Wulz, V Mossolov, N Shumeiko, J Suarez Gonzalez, S Alderweireldt, T Cornelis, E A De Wolf, X Janssen, A Knutsson, J Lauwers, S Luyckx, M Van De Klundert, H Van Haevermaet, P Van Mechelen, N Van Remortel, A Van Spilbeeck, S Abu Zeid, F Blekman, J D'Hondt, N Daci, I De Bruyn, K Deroover, N Heracleous, S Lowette, S Moortgat, L Moreels, A Olbrechts, Q Python, S Tavernier, W Van Doninck, P Van Mulders, I Van Parijs, H Brun, C Caillol, B Clerbaux, G De Lentdecker, H Delannoy, G Fasanella, L Favart, R Goldouzian, A Grebenyuk, G Karapostoli, T Lenzi, A Léonard, T Maerschalk, A Marinov, A Randle-Conde, T Seva, C Vander Velde, P Vanlaer, R Yonamine, F Zenoni, F Zhang, A Cimmino, D Dobur, A Fagot, G Garcia, M Gul, J Mccartin, D Poyraz, S Salva, R Schöfbeck, M Tytgat, W Van Driessche, E Yazgan, N Zaganidis, C Beluffi, O Bondu, S Brochet, G Bruno, A Caudron, L Ceard, S De Visscher, C Delaere, M Delcourt, L Forthomme, B Francois, A Giammanco, A Jafari, P Jez, M Komm, V Lemaitre, A Magitteri, A Mertens, M Musich, C Nuttens, K Piotrzkowski, L Quertenmont, M Selvaggi, M Vidal Marono, S Wertz, N Beliy, W L Aldá Júnior, F L Alves, G A Alves, L Brito, M Correa Martins Junior, C Hensel, A Moraes, M E Pol, P Rebello Teles, E Belchior Batista Das Chagas, W Carvalho, J Chinellato, A Custódio, E M Da Costa, G G Da Silveira, D De Jesus Damiao, C De Oliveira Martins, S Fonseca De Souza, L M Huertas Guativa, H Malbouisson, D Matos Figueiredo, C Mora Herrera, L Mundim, H Nogima, W L Prado Da Silva, A Santoro, A Sznajder, E J Tonelli Manganote, A Vilela Pereira, S Ahuja, C A Bernardes, S Dogra, T R Fernandez Perez Tomei, E M Gregores, P G Mercadante, C S Moon, S F Novaes, Sandra S Padula, D Romero Abad, J C Ruiz Vargas, A Aleksandrov, R Hadjiiska, P Iaydjiev, M Rodozov, S Stoykova, G Sultanov, M Vutova, A Dimitrov, I Glushkov, L Litov, B Pavlov, P Petkov, W Fang, M Ahmad, J G Bian, G M Chen, H S Chen, M Chen, Y Chen, T Cheng, R Du, C H Jiang, D Leggat, Z Liu, F Romeo, S M Shaheen, A Spiezia, J Tao, C Wang, Z Wang, H Zhang, J Zhao, C Asawatangtrakuldee, Y Ban, Q Li, S Liu, Y Mao, S J Qian, D Wang, Z Xu, C Avila, A Cabrera, L F Chaparro Sierra, C Florez, J P Gomez, J D Ruiz Alvarez, J C Sanabria, N Godinovic, D Lelas, I Puljak, P M Ribeiro Cipriano, Z Antunovic, M Kovac, V Brigljevic, D Ferencek, K Kadija, J Luetic, S Micanovic, L Sudic, A Attikis, G Mavromanolakis, J Mousa, C Nicolaou, F Ptochos, P A Razis, H Rykaczewski, M Finger, M Finger, E Carrera Jarrin, A Awad, S Elgammal, A Mohamed, E Salama, B Calpas, M Kadastik, M Murumaa, L Perrini, M Raidal, A Tiko, C Veelken, P Eerola, J Pekkanen, M Voutilainen, J Härkönen, V Karimäki, R Kinnunen, T Lampén, K Lassila-Perini, S Lehti, T Lindén, P Luukka, T Peltola, J Tuominiemi, E Tuovinen, L Wendland, J Talvitie, T Tuuva, M Besancon, F Couderc, M Dejardin, D Denegri, B Fabbro, J L Faure, C Favaro, F Ferri, S Ganjour, S Ghosh, A Givernaud, P Gras, G Hamel de Monchenault, P Jarry, E Locci, M Machet, J Malcles, J Rander, A Rosowsky, M Titov, A Zghiche, A Abdulsalam, I Antropov, S Baffioni, F Beaudette, P Busson, L Cadamuro, E Chapon, C Charlot, O Davignon, R Granier de Cassagnac, M Jo, S Lisniak, P Miné, I N Naranjo, M Nguyen, C Ochando, G Ortona, P Paganini, P Pigard, S Regnard, R Salerno, Y Sirois, T Strebler, Y Yilmaz, A Zabi, J-L Agram, J Andrea, A Aubin, D Bloch, J-M Brom, M Buttignol, E C Chabert, N Chanon, C Collard, E Conte, X Coubez, J-C Fontaine, D Gelé, U Goerlach, A-C Le Bihan, J A Merlin, K Skovpen, P Van Hove, S Gadrat, S Beauceron, C Bernet, G Boudoul, E Bouvier, C A Carrillo Montoya, R Chierici, D Contardo, B Courbon, P Depasse, H El Mamouni, J Fan, J Fay, S Gascon, M Gouzevitch, G Grenier, B Ille, F Lagarde, I B Laktineh, M Lethuillier, L Mirabito, A L Pequegnot, S Perries, A Popov, D Sabes, V Sordini, M Vander Donckt, P Verdier, S Viret, T Toriashvili, Z Tsamalaidze, C Autermann, S Beranek, L Feld, A Heister, M K Kiesel, K Klein, M Lipinski, A Ostapchuk, M Preuten, F Raupach, S Schael, C Schomakers, J F Schulte, J Schulz, T Verlage, H Weber, V Zhukov, M Ata, M Brodski, E Dietz-Laursonn, D Duchardt, M Endres, M Erdmann, S Erdweg, T Esch, R Fischer, A Güth, T Hebbeker, C Heidemann, K Hoepfner, S Knutzen, M Merschmeyer, A Meyer, P Millet, S Mukherjee, M Olschewski, K Padeken, P Papacz, T Pook, M Radziej, H Reithler, M Rieger, F Scheuch, L Sonnenschein, D Teyssier, S Thüer, V Cherepanov, Y Erdogan, G Flügge, H Geenen, M Geisler, F Hoehle, B Kargoll, T Kress, A Künsken, J Lingemann, A Nehrkorn, A Nowack, I M Nugent, C Pistone, O Pooth, A Stahl, M Aldaya Martin, I Asin, K Beernaert, O Behnke, U Behrens, A A Bin Anuar, K Borras, A Campbell, P Connor, C Contreras-Campana, F Costanza, C Diez Pardos, G Dolinska, G Eckerlin, D Eckstein, T Eichhorn, E Gallo, J Garay Garcia, A Geiser, A Gizhko, J M Grados Luyando, P Gunnellini, A Harb, J Hauk, M Hempel, H Jung, A Kalogeropoulos, O Karacheban, M Kasemann, J Kieseler, C Kleinwort, I Korol, W Lange, A Lelek, J Leonard, K Lipka, A Lobanov, W Lohmann, R Mankel, I-A Melzer-Pellmann, A B Meyer, G Mittag, J Mnich, A Mussgiller, E Ntomari, D Pitzl, R Placakyte, A Raspereza, B Roland, M Ö Sahin, P Saxena, T Schoerner-Sadenius, C Seitz, S Spannagel, N Stefaniuk, K D Trippkewitz, G P Van Onsem, R Walsh, C Wissing, V Blobel, M Centis Vignali, A R Draeger, T Dreyer, J Erfle, E Garutti, K Goebel, D Gonzalez, M Görner, J Haller, M Hoffmann, R S Höing, A Junkes, R Klanner, R Kogler, N Kovalchuk, T Lapsien, T Lenz, I Marchesini, D Marconi, M Meyer, M Niedziela, D Nowatschin, J Ott, F Pantaleo, T Peiffer, A Perieanu, N Pietsch, J Poehlsen, C Sander, C Scharf, P Schleper, E Schlieckau, A Schmidt, S Schumann, J Schwandt, H Stadie, G Steinbrück, F M Stober, M Stöver, H Tholen, D Troendle, E Usai, L Vanelderen, A Vanhoefer, B Vormwald, C Barth, C Baus, J Berger, E Butz, T Chwalek, F Colombo, W De Boer, A Dierlamm, S Fink, R Friese, M Giffels, A Gilbert, D Haitz, F Hartmann, S M Heindl, U Husemann, I Katkov, A Kornmayer, P Lobelle Pardo, B Maier, H Mildner, M U Mozer, T Müller, Th Müller, M Plagge, G Quast, K Rabbertz, S Röcker, F Roscher, M Schröder, G Sieber, H J Simonis, R Ulrich, J Wagner-Kuhr, S Wayand, M Weber, T Weiler, S Williamson, C Wöhrmann, R Wolf, G Anagnostou, G Daskalakis, T Geralis, V A Giakoumopoulou, A Kyriakis, D Loukas, I Topsis-Giotis, A Agapitos, S Kesisoglou, A Panagiotou, N Saoulidou, E Tziaferi, I Evangelou, G Flouris, C Foudas, P Kokkas, N Loukas, N Manthos, I Papadopoulos, E Paradas, N Filipovic, G Bencze, C Hajdu, P Hidas, D Horvath, F Sikler, V Veszpremi, G Vesztergombi, A J Zsigmond, N Beni, S Czellar, J Karancsi, J Molnar, Z Szillasi, M Bartók, A Makovec, P Raics, Z L Trocsanyi, B Ujvari, S Bahinipati, S Choudhury, P Mal, K Mandal, A Nayak, D K Sahoo, N Sahoo, S K Swain, S Bansal, S B Beri, V Bhatnagar, R Chawla, R Gupta, U Bhawandeep, A K Kalsi, A Kaur, M Kaur, R Kumar, A Mehta, M Mittal, J B Singh, G Walia, Ashok Kumar, A Bhardwaj, B C Choudhary, R B Garg, S Keshri, A Kumar, S Malhotra, M Naimuddin, N Nishu, K Ranjan, R Sharma, V Sharma, R Bhattacharya, S Bhattacharya, K Chatterjee, S Dey, S Dutt, S Dutta, S Ghosh, N Majumdar, A Modak, K Mondal, S Mukhopadhyay, S Nandan, A Purohit, A Roy, D Roy, S Roy Chowdhury, S Sarkar, M Sharan, S Thakur, P K Behera, R Chudasama, D Dutta, V Jha, V Kumar, A K Mohanty, P K Netrakanti, L M Pant, P Shukla, A Topkar, T Aziz, S Banerjee, S Bhowmik, R M Chatterjee, R K Dewanjee, S Dugad, S Ganguly, M Guchait, A Gurtu, Sa Jain, G Kole, S Kumar, B Mahakud, M Maity, G Majumder, K Mazumdar, S Mitra, G B Mohanty, B Parida, T Sarkar, N Sur, B Sutar, N Wickramage, S 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Ruckstuhl, R Rusack, N Tambe, J Turkewitz, J G Acosta, S Oliveros, E Avdeeva, R Bartek, K Bloom, S Bose, D R Claes, A Dominguez, C Fangmeier, R Gonzalez Suarez, R Kamalieddin, D Knowlton, I Kravchenko, F Meier, J Monroy, J E Siado, G R Snow, B Stieger, M Alyari, J Dolen, J George, A Godshalk, C Harrington, I Iashvili, J Kaisen, A Kharchilava, A Kumar, A Parker, S Rappoccio, B Roozbahani, G Alverson, E Barberis, D Baumgartel, M Chasco, A Hortiangtham, A Massironi, D M Morse, D Nash, T Orimoto, R Teixeira De Lima, D Trocino, R-J Wang, D Wood, S Bhattacharya, K A Hahn, A Kubik, J F Low, N Mucia, N Odell, B Pollack, M H Schmitt, K Sung, M Trovato, M Velasco, N Dev, M Hildreth, K Hurtado Anampa, C Jessop, D J Karmgard, N Kellams, K Lannon, N Marinelli, F Meng, C Mueller, Y Musienko, M Planer, A Reinsvold, R Ruchti, N Rupprecht, G Smith, S Taroni, N Valls, M Wayne, M Wolf, A Woodard, J Alimena, L Antonelli, J Brinson, B Bylsma, L S Durkin, S Flowers, B Francis, A Hart, C Hill, R Hughes, W Ji, B Liu, W Luo, D Puigh, M Rodenburg, B L Winer, H W Wulsin, O Driga, P Elmer, J Hardenbrook, P Hebda, D Marlow, T Medvedeva, M Mooney, J Olsen, C Palmer, P Piroué, D Stickland, C Tully, A Zuranski, S Malik, A Barker, V E Barnes, D Benedetti, S Folgueras, L Gutay, M K Jha, M Jones, A W Jung, K Jung, D H Miller, N Neumeister, B C Radburn-Smith, X Shi, J Sun, A Svyatkovskiy, F Wang, W Xie, L Xu, N Parashar, J Stupak, A Adair, B Akgun, Z Chen, K M Ecklund, F J M Geurts, M Guilbaud, W Li, B Michlin, M Northup, B P Padley, R Redjimi, J Roberts, J Rorie, Z Tu, J Zabel, B Betchart, A Bodek, P de Barbaro, R Demina, Y T Duh, Y Eshaq, T Ferbel, M Galanti, A Garcia-Bellido, J Han, O Hindrichs, A Khukhunaishvili, K H Lo, P Tan, M Verzetti, J P Chou, E Contreras-Campana, Y Gershtein, T A Gómez Espinosa, E Halkiadakis, M Heindl, D Hidas, E Hughes, S Kaplan, R Kunnawalkam Elayavalli, S Kyriacou, A Lath, K Nash, H Saka, S Salur, S Schnetzer, D Sheffield, S Somalwar, R Stone, S Thomas, P Thomassen, M Walker, M Foerster, J Heideman, G Riley, K Rose, S Spanier, K Thapa, O Bouhali, A Castaneda Hernandez, A Celik, M Dalchenko, M De Mattia, A Delgado, S Dildick, R Eusebi, W Flanagan, J Gilmore, T Huang, E Juska, T Kamon, V Krutelyov, R Mueller, Y Pakhotin, R Patel, A Perloff, L Perniè, D Rathjens, A Rose, A Safonov, A Tatarinov, K A Ulmer, N Akchurin, C Cowden, J Damgov, C Dragoiu, P R Dudero, J Faulkner, S Kunori, K Lamichhane, S W Lee, T Libeiro, S Undleeb, I Volobouev, Z Wang, A G Delannoy, S Greene, A Gurrola, R Janjam, W Johns, C Maguire, A Melo, H Ni, P Sheldon, S Tuo, J Velkovska, Q Xu, M W Arenton, P Barria, B Cox, J Goodell, R Hirosky, A Ledovskoy, H Li, C Neu, T Sinthuprasith, X Sun, Y Wang, E Wolfe, F Xia, C Clarke, R Harr, P E Karchin, C Kottachchi Kankanamge Don, P Lamichhane, J Sturdy, D A Belknap, S Dasu, L Dodd, S Duric, B Gomber, M Grothe, M Herndon, A Hervé, P Klabbers, A Lanaro, A Levine, K Long, R Loveless, I Ojalvo, T Perry, G A Pierro, G Polese, T Ruggles, A Savin, A Sharma, N Smith, W H Smith, D Taylor, P Verwilligen, N Woods
A first search for pair production of dark matter candidates through vector boson fusion in proton-proton collisions at sqrt[s]=8  TeV is performed with the CMS detector. The vector boson fusion topology enhances missing transverse momentum, providing a way to probe supersymmetry, even in the case of a compressed mass spectrum. The data sample corresponds to an integrated luminosity of 18.5  fb^{-1}, recorded by the CMS experiment. The observed dijet mass spectrum is consistent with the standard model expectation...
January 13, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28106624/intraoperative-electrocochleography-a-window-into-endolymphatic-hydrops-in-a-patient-with-an-endolymphatic-sac-tumor
#14
William J Riggs, Dominic J Catalano, Michael S Harris, Oliver F Adunka, Aaron C Moberly
OBJECTIVES: Intraoperative electrocochleography (ECochG) provides valuable information regarding inner ear function during surgical procedures. Here, we report findings from ECochG collected at three time intervals during the management of a patient with symptoms of inner ear hydrops. PATIENTS: A 38-year-old man with an endolymphatic sac tumor who demonstrated classic Ménière's symptoms. INTERVENTIONS: Endolymphatic shunt, tumor biopsy, and definitive resection of an endolymphatic sac tumor...
January 18, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28094794/diversity-and-carbon-storage-across-the-tropical-forest-biome
#15
Martin J P Sullivan, Joey Talbot, Simon L Lewis, Oliver L Phillips, Lan Qie, Serge K Begne, Jerôme Chave, Aida Cuni-Sanchez, Wannes Hubau, Gabriela Lopez-Gonzalez, Lera Miles, Abel Monteagudo-Mendoza, Bonaventure Sonké, Terry Sunderland, Hans Ter Steege, Lee J T White, Kofi Affum-Baffoe, Shin-Ichiro Aiba, Everton Cristo de Almeida, Edmar Almeida de Oliveira, Patricia Alvarez-Loayza, Esteban Álvarez Dávila, Ana Andrade, Luiz E O C Aragão, Peter Ashton, Gerardo A Aymard C, Timothy R Baker, Michael Balinga, Lindsay F Banin, Christopher Baraloto, Jean-Francois Bastin, Nicholas Berry, Jan Bogaert, Damien Bonal, Frans Bongers, Roel Brienen, José Luís C Camargo, Carlos Cerón, Victor Chama Moscoso, Eric Chezeaux, Connie J Clark, Álvaro Cogollo Pacheco, James A Comiskey, Fernando Cornejo Valverde, Eurídice N Honorio Coronado, Greta Dargie, Stuart J Davies, Charles De Canniere, Marie Noel Djuikouo K, Jean-Louis Doucet, Terry L Erwin, Javier Silva Espejo, Corneille E N Ewango, Sophie Fauset, Ted R Feldpausch, Rafael Herrera, Martin Gilpin, Emanuel Gloor, Jefferson S Hall, David J Harris, Terese B Hart, Kuswata Kartawinata, Lip Khoon Kho, Kanehiro Kitayama, Susan G W Laurance, William F Laurance, Miguel E Leal, Thomas Lovejoy, Jon C Lovett, Faustin Mpanya Lukasu, Jean-Remy Makana, Yadvinder Malhi, Leandro Maracahipes, Beatriz S Marimon, Ben Hur Marimon Junior, Andrew R Marshall, Paulo S Morandi, John Tshibamba Mukendi, Jaques Mukinzi, Reuben Nilus, Percy Núñez Vargas, Nadir C Pallqui Camacho, Guido Pardo, Marielos Peña-Claros, Pascal Pétronelli, Georgia C Pickavance, Axel Dalberg Poulsen, John R Poulsen, Richard B Primack, Hari Priyadi, Carlos A Quesada, Jan Reitsma, Maxime Réjou-Méchain, Zorayda Restrepo, Ervan Rutishauser, Kamariah Abu Salim, Rafael P Salomão, Ismayadi Samsoedin, Douglas Sheil, Rodrigo Sierra, Marcos Silveira, J W Ferry Slik, Lisa Steel, Hermann Taedoumg, Sylvester Tan, John W Terborgh, Sean C Thomas, Marisol Toledo, Peter M Umunay, Luis Valenzuela Gamarra, Ima Célia Guimarães Vieira, Vincent A Vos, Ophelia Wang, Simon Willcock, Lise Zemagho
Tropical forests are global centres of biodiversity and carbon storage. Many tropical countries aspire to protect forest to fulfil biodiversity and climate mitigation policy targets, but the conservation strategies needed to achieve these two functions depend critically on the tropical forest tree diversity-carbon storage relationship. Assessing this relationship is challenging due to the scarcity of inventories where carbon stocks in aboveground biomass and species identifications have been simultaneously and robustly quantified...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28073150/the-impact-of-overdiagnosis-on-the-selection-of-efficient-lung-cancer-screening-strategies
#16
Summer S Han, Kevin Ten Haaf, William D Hazelton, Vidit N Munshi, Jihyoun Jeon, Saadet A Erdogan, Colden Johanson, Pamela M McMahon, Rafael Meza, Chung Yin Kong, Eric J Feuer, Harry J de Koning, Sylvia K Plevritis
The U.S. Preventive Services Task Force (USPSTF) recently updated their national lung screening guidelines and recommended low-dose computed tomography (LDCT) for lung cancer (LC) screening through age 80. However, the risk of overdiagnosis among older populations is a concern. Using four comparative models from the Cancer Intervention and Surveillance Modeling Network, we evaluate the overdiagnosis of the screening program recommended by USPSTF in the U.S. 1950 birth cohort. We estimate the number of LC deaths averted by screening (D) per overdiagnosed case (O), yielding the ratio D/O, to quantify the trade-off between the harms and benefits of LDCT...
January 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28070772/primary-care-providers-beliefs-and-recommendations-and-use-of-screening-mammography-by-their-patients
#17
Jennifer S Haas, William E Barlow, Marilyn M Schapira, Charles D MacLean, Carrie N Klabunde, Brian L Sprague, Elisabeth F Beaber, Jane S Chen, Asaf Bitton, Tracy Onega, Kimberly Harris, Anna N A Tosteson
BACKGROUND: Revised breast cancer screening guidelines have fueled debate about the effectiveness and frequency of screening mammography, encouraging discussion between women and their providers. OBJECTIVE: To examine whether primary care providers' (PCPs') beliefs about the effectiveness and frequency of screening mammography are associated with utilization by their patients. DESIGN: Cross-sectional survey data from PCPs (2014) from three primary care networks affiliated with the Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) consortium, linked with data about their patients' mammography use (2011-2014)...
January 9, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28055120/evaluation-of-proposed-staging-systems-for-human-papillomavirus-related-oropharyngeal-squamous-cell-carcinoma
#18
Ian-James Malm, Caleb J Fan, Linda X Yin, David X Li, Wayne M Koch, Christine G Gourin, Karen T Pitman, Jeremy D Richmon, William H Westra, Hyunseok Kang, Harry Quon, David W Eisele, Carole Fakhry
BACKGROUND: Patients with human papillomavirus (HPV)-related oropharyngeal cancer (OPC) have improved survival when compared with those with HPV-negative OPC. Unfortunately, the American Joint Committee on Cancer seventh edition (AJCC-7ed) staging system does not account for the prognostic advantage observed with HPV-positive OPC. The purpose of the current study was to validate and compare 2 recently proposed staging systems for HPV-positive OPC. METHODS: Patients treated for HPV-positive OPC from 2005 to 2015 at Johns Hopkins Hospital (JHH) were included for analysis...
January 5, 2017: Cancer
https://www.readbyqxmd.com/read/28031423/neurological-injury-and-cerebral-blood-flow-in-single-ventricles-throughout-staged-surgical-reconstruction
#19
Mark A Fogel, Christine Li, Okan U Elci, Tom Pawlowski, Peter J Schwab, Felice Wilson, Susan C Nicolson, Lisa M Montenegro, Laura Diaz, Thomas L Spray, J William Gaynor, Stephanie Fuller, Christopher Mascio, Marc S Keller, Matthew A Harris, Kevin K Whitehead, Jim Bethel, Arastoo Vossough, Daniel J Licht
BACKGROUND: Patients with a single ventricle experience a high rate of brain injury and adverse neurodevelopmental outcome; however, the incidence of brain abnormalities throughout surgical reconstruction and their relationship with cerebral blood flow, oxygen delivery, and carbon dioxide reactivity remain unknown. METHODS: Patients with a single ventricle were studied with magnetic resonance imaging scans immediately prior to bidirectional Glenn (pre-BDG), before Fontan (BDG), and then 3 to 9 months after Fontan reconstruction...
February 14, 2017: Circulation
https://www.readbyqxmd.com/read/28031061/which-comorbid-conditions-should-we-be-analyzing-as-risk-factors-for-healthcare-associated-infections
#20
Anthony D Harris, Lisa Pineles, Deverick Anderson, Keith F Woeltje, William E Trick, Keith S Kaye, Deborah S Yokoe, Ann-Christine Nyquist, David P Calfee, Surbhi Leekha
OBJECTIVE To determine which comorbid conditions are considered causally related to central-line associated bloodstream infection (CLABSI) and surgical-site infection (SSI) based on expert consensus. DESIGN Using the Delphi method, we administered an iterative, 2-round survey to 9 infectious disease and infection control experts from the United States. METHODS Based on our selection of components from the Charlson and Elixhauser comorbidity indices, 35 different comorbid conditions were rated from 1 (not at all related) to 5 (strongly related) by each expert separately for CLABSI and SSI, based on perceived relatedness to the outcome...
December 29, 2016: Infection Control and Hospital Epidemiology
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