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William S Harris

Theresia Jumbe, Sarah S Comstock, William S Harris, Joyce Kinabo, Matthew B Pontifex, Jenifer I Fenton
Essential fatty acids (EFA) are PUFA that are metabolised to long-chain PUFA and are important for brain development and cognitive function. The objective of this study was to determine the association between whole-blood EFA and cognitive function in Tanzanian children. A total of 325 2-6-year-old children attempted the dimensional change card sort (DCCS) tasks to assess executive function. Blood samples were collected for fatty acid (FA) analysis by GC. Associations between executive function and FA levels were assessed by regression...
October 21, 2016: British Journal of Nutrition
Alex H S Harris, Cheng Chen, Beth A Mohr, Rachel Sayko Adams, Thomas V Williams, Mary Jo Larson
No abstract text is available yet for this article.
October 2016: Military Medicine
Kate J Bowen, William S Harris, Penny M Kris-Etherton
Early secondary prevention trials of fish and omega-3 polyunsaturated fatty acid (PUFA) capsules reported beneficial effects on cardiovascular disease (CVD) outcomes, including all-cause mortality and sudden cardiac death. These clinical findings, as well as observational and experimental data, demonstrated that omega-3 PUFAs reduced the risk of coronary outcomes and overall mortality and were the basis for recommendations made in the early 2000s to increase omega-3 PUFA intake. In the last 6 years, however, results from both primary and secondary prevention trials have generally failed to show a beneficial effect of omega-3 PUFA supplementation, bringing current recommendations into question...
November 2016: Current Treatment Options in Cardiovascular Medicine
James P B O'Connor, Eric O Aboagye, Judith E Adams, Hugo J W L Aerts, Sally F Barrington, Ambros J Beer, Ronald Boellaard, Sarah E Bohndiek, Michael Brady, Gina Brown, David L Buckley, Thomas L Chenevert, Laurence P Clarke, Sandra Collette, Gary J Cook, Nandita M deSouza, John C Dickson, Caroline Dive, Jeffrey L Evelhoch, Corinne Faivre-Finn, Ferdia A Gallagher, Fiona J Gilbert, Robert J Gillies, Vicky Goh, John R Griffiths, Ashley M Groves, Steve Halligan, Adrian L Harris, David J Hawkes, Otto S Hoekstra, Erich P Huang, Brian F Hutton, Edward F Jackson, Gordon C Jayson, Andrew Jones, Dow-Mu Koh, Denis Lacombe, Philippe Lambin, Nathalie Lassau, Martin O Leach, Ting-Yim Lee, Edward L Leen, Jason S Lewis, Yan Liu, Mark F Lythgoe, Prakash Manoharan, Ross J Maxwell, Kenneth A Miles, Bruno Morgan, Steve Morris, Tony Ng, Anwar R Padhani, Geoff J M Parker, Mike Partridge, Arvind P Pathak, Andrew C Peet, Shonit Punwani, Andrew R Reynolds, Simon P Robinson, Lalitha K Shankar, Ricky A Sharma, Dmitry Soloviev, Sigrid Stroobants, Daniel C Sullivan, Stuart A Taylor, Paul S Tofts, Gillian M Tozer, Marcel van Herk, Simon Walker-Samuel, James Wason, Kaye J Williams, Paul Workman, Thomas E Yankeelov, Kevin M Brindle, Lisa M McShane, Alan Jackson, John C Waterton
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and drug development. New IBs need to be established either as useful tools for testing research hypotheses in clinical trials and research studies, or as clinical decision-making tools for use in healthcare, by crossing 'translational gaps' through validation and qualification...
October 11, 2016: Nature Reviews. Clinical Oncology
Rahul Chaudhary, Katayoon Saadin, Kevin P Bliden, William S Harris, Bao Dinh, Tushar Sharma, Udaya S Tantry, Paul A Gurbel
INTRODUCTION: We sought to determine the associations between plasma eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) levels and various cardiovascular risk factors and with the use of fish oil supplements (FOS). PATIENTS AND METHODS: Patients with suspected coronary artery disease (CAD) undergoing cardiac catheterization (n=433) were studied. Serum fatty acid (FA) composition, the concentrations of lipids and biomarkers of oxidative stress, and dietary/lifestyle factors were measured...
October 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
Josalyn L Cho, Morris F Ling, David C Adams, Lucas Faustino, Sabina A Islam, Roshi Afshar, Jason W Griffith, Robert S Harris, Aylwin Ng, Giorgia Radicioni, Amina A Ford, Andre K Han, Ramnik Xavier, William W Kwok, Richard Boucher, James J Moon, Daniel L Hamilos, Mehmet Kesimer, Melissa J Suter, Benjamin D Medoff, Andrew D Luster
Despite systemic sensitization, not all allergic individuals develop asthma symptoms upon airborne allergen exposure. Determination of the factors that lead to the asthma phenotype in allergic individuals could guide treatment and identify novel therapeutic targets. We used segmental allergen challenge of allergic asthmatics (AA) and allergic nonasthmatic controls (AC) to determine whether there are differences in the airway immune response or airway structural cells that could drive the development of asthma...
October 5, 2016: Science Translational Medicine
Pia Viikilä, Antti J Kivelä, Harri Mustonen, Selja Koskensalo, Abdul Waheed, William S Sly, Jaromir Pastorek, Silvia Pastorekova, Seppo Parkkila, Caj Haglund
AIM: To investigate expression of four alpha-carbonic anhydrases (CAs) in colorectal carcinomas (CRC) and compare the results with patients' survival. METHODS: Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA II, CA VII, CA IX, and CA XII. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients' survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients' age, and gender...
September 28, 2016: World Journal of Gastroenterology: WJG
William T Harris, J Todd Boyd, Gary L McPhail, Alan S Brody, Rhonda D Szczesniak, Leslie L Korbee, Michael L Baker, John P Clancy
RATIONALE: Refractory lung function decline in association with recurrent pulmonary exacerbations is a common, yet poorly explained finding in CF. We reviewed clinically-indicated lung biopsy specimens obtained during a period of persistent decline to investigate histopathologic mechanisms of pulmonary deterioration during adolescence and early adulthood. OBJECTIVES: To determine if peribronchiolar remodeling is prominent in lung biopsy specimens obtained in CF adolescents refractory to conventional therapy...
September 29, 2016: Annals of the American Thoracic Society
Momoko Horikoshi, Robin N Beaumont, Felix R Day, Nicole M Warrington, Marjolein N Kooijman, Juan Fernandez-Tajes, Bjarke Feenstra, Natalie R van Zuydam, Kyle J Gaulton, Niels Grarup, Jonathan P Bradfield, David P Strachan, Ruifang Li-Gao, Tarunveer S Ahluwalia, Eskil Kreiner, Rico Rueedi, Leo-Pekka Lyytikäinen, Diana L Cousminer, Ying Wu, Elisabeth Thiering, Carol A Wang, Christian T Have, Jouke-Jan Hottenga, Natalia Vilor-Tejedor, Peter K Joshi, Eileen Tai Hui Boh, Ioanna Ntalla, Niina Pitkänen, Anubha Mahajan, Elisabeth M van Leeuwen, Raimo Joro, Vasiliki Lagou, Michael Nodzenski, Louise A Diver, Krina T Zondervan, Mariona Bustamante, Pedro Marques-Vidal, Josep M Mercader, Amanda J Bennett, Nilufer Rahmioglu, Dale R Nyholt, Ronald C W Ma, Claudia H T Tam, Wing Hung Tam, Santhi K Ganesh, Frank J A van Rooij, Samuel E Jones, Po-Ru Loh, Katherine S Ruth, Marcus A Tuke, Jessica Tyrrell, Andrew R Wood, Hanieh Yaghootkar, Denise M Scholtens, Lavinia Paternoster, Inga Prokopenko, Peter Kovacs, Mustafa Atalay, Sara M Willems, Kalliope Panoutsopoulou, Xu Wang, Lisbeth Carstensen, Frank Geller, Katharina E Schraut, Mario Murcia, Catharina E M van Beijsterveldt, Gonneke Willemsen, Emil V R Appel, Cilius E Fonvig, Caecilie Trier, Carla M T Tiesler, Marie Standl, Zoltán Kutalik, Sílvia Bonàs-Guarch, David M Hougaard, Friman Sánchez, David Torrents, Johannes Waage, Mads V Hollegaard, Hugoline G de Haan, Frits R Rosendaal, Carolina Medina-Gomez, Susan M Ring, Gibran Hemani, George McMahon, Neil R Robertson, Christopher J Groves, Claudia Langenberg, Jian'an Luan, Robert A Scott, Jing Hua Zhao, Frank D Mentch, Scott M MacKenzie, Rebecca M Reynolds, William L Lowe, Anke Tönjes, Michael Stumvoll, Virpi Lindi, Timo A Lakka, Cornelia M van Duijn, Wieland Kiess, Antje Körner, Thorkild I A Sørensen, Harri Niinikoski, Katja Pahkala, Olli T Raitakari, Eleftheria Zeggini, George V Dedoussis, Yik-Ying Teo, Seang-Mei Saw, Mads Melbye, Harry Campbell, James F Wilson, Martine Vrijheid, Eco J C N de Geus, Dorret I Boomsma, Haja N Kadarmideen, Jens-Christian Holm, Torben Hansen, Sylvain Sebert, Andrew T Hattersley, Lawrence J Beilin, John P Newnham, Craig E Pennell, Joachim Heinrich, Linda S Adair, Judith B Borja, Karen L Mohlke, Johan G Eriksson, Elisabeth Widén, Mika Kähönen, Jorma S Viikari, Terho Lehtimäki, Peter Vollenweider, Klaus Bønnelykke, Hans Bisgaard, Dennis O Mook-Kanamori, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Charlotta Pisinger, Oluf Pedersen, Christine Power, Elina Hyppönen, Nicholas J Wareham, Hakon Hakonarson, Eleanor Davies, Brian R Walker, Vincent W V Jaddoe, Marjo-Riitta Järvelin, Struan F A Grant, Allan A Vaag, Debbie A Lawlor, Timothy M Frayling, George Davey Smith, Andrew P Morris, Ken K Ong, Janine F Felix, Nicholas J Timpson, John R B Perry, David M Evans, Mark I McCarthy, Rachel M Freathy
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease. These life-course associations have often been attributed to the impact of an adverse early life environment. Here, we performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where fetal genotype was associated with BW (P < 5 × 10(-8))...
September 28, 2016: Nature
Chrispin Chaguza, Cheryl P Andam, Simon R Harris, Jennifer E Cornick, Marie Yang, Laura Bricio-Moreno, Arox W Kamng'ona, Julian Parkhill, Neil French, Robert S Heyderman, Aras Kadioglu, Dean B Everett, Stephen D Bentley, William P Hanage
: Streptococcus pneumoniae causes a high burden of invasive pneumococcal disease (IPD) globally, especially in children from resource-poor settings. Like many bacteria, the pneumococcus can import DNA from other strains or even species by transformation and homologous recombination, which has allowed the pneumococcus to evade clinical interventions such as antibiotics and pneumococcal conjugate vaccines (PCVs). Pneumococci are enclosed in a complex polysaccharide capsule that determines the serotype; the capsule varies in size and is associated with properties including carriage prevalence and virulence...
September 27, 2016: MBio
Lahiru S Wijedasa, Jyrki Jauhiainen, Mari Könönen, Maija Lampela, Harri Vasander, Marie-Claire LeBlanc, Stephanie Evers, Thomas E L Smith, Catherine M Yule, Helena Varkkey, Massimo Lupascu, Faizal Parish, Ian Singleton, Gopalasamy R Clements, Sheema Abdul Aziz, Mark E Harrison, Susan Cheyne, Gusti Z Anshari, Erik Meijaard, Jenny E Goldstein, Susan Waldron, Kristell Hergoualc'h, René Dommain, Steve Frolking, Christopher D Evans, Mary Rose C Posa, Paul H Glaser, Nyoman Suryadiputra, Reza Lubis, Truly Santika, Rory Padfield, Sofyan Kurnianto, Panut Hadisiswoyo, Teck Wyn Lim, Susan E Page, Vincent Gauci, Peter J van der Meer, Helen Buckland, Fabien Garnier, Marshall K Samuel, Liza Nuriati Lim Kim Choo, Patrick O'Reilly, Matthew Warren, Surin Suksuwan, Elham Sumarga, Anuj Jain, William F Laurance, John Couwenberg, Hans Joosten, Ronald Vernimmen, Aljosja Hooijer, Chris Malins, Mark A Cochrane, Balu Perumal, Florian Siegert, Kelvin S-H Peh, Louis-Pierre Comeau, Louis Verchot, Charles F Harvey, Alex Cobb, Zeehan Jaafar, Henk Wösten, Solichin Manuri, Moritz Müller, Wim Giesen, Jacob Phelps, Ding Li Yong, Marcel Silvius, Béatrice M M Wedeux, Alison Hoyt, Mitsuru Osaki, Hirano Takashi, Hidenori Takahashi, Takashi S Kohyama, Akira Haraguchi, Nunung P Nugroho, David A Coomes, Le Phat Quoi, Alue Dohong, Haris Gunawan, David L A Gaveau, Andreas Langner, Felix K S Lim, David P Edwards, Xingli Giam, Guido van der Werf, Rachel Carmenta, Caspar C Verwer, Luke Gibson, Laure Grandois, Laura Linda Bozena Graham, Jhanson Regalino, Serge A Wich, Jack Rieley, Nicholas Kettridge, Chloe Brown, Romain Pirard, Sam Moore, B Ripoll Capilla, Uwe Ballhorn, Hua Chew Ho, Agata Hoscilo, Sandra Lohberger, Theodore A Evans, Nina Yulianti, Grace Blackham, Onrizal, Simon Husson, Daniel Murdiyarso, Sunita Pangala, Lydia E S Cole, Luca Tacconi, Hendrik Segah, Prayoto Tonoto, Janice S H Lee, Gerald Schmilewski, Stephan Wulffraat, Erianto Indra Putra, Megan E Cattau, R S Clymo, Ross Morrison, Aazani Mujahid, Jukka Miettinen, Soo Chin Liew, Samu Valpola, David Wilson, Laura D'Arcy, Michiel Gerding, Siti Sundari, Sara A Thornton, Barbara Kalisz, Stephen J Chapman, Ahmad Suhaizi Mat Su, Imam Basuki, Masayuki Itoh, Carl Traeholt, Sean Sloan, Alexander K Sayok, Roxane Andersen
The first International Peat Congress (IPC) held in the tropics - in Kuching (Malaysia) - brought together over 1000 international peatland scientists and industrial partners from across the world ("International Peat Congress with over 1000 participants!," 2016). The congress covered all aspects of peatland ecosystems and their management, with a strong focus on the environmental, societal and economic challenges associated with contemporary large-scale agricultural conversion of tropical peat. This article is protected by copyright...
September 27, 2016: Global Change Biology
Karriem S Watson, Amanda C Blok, Joanna Buscemi, Yamile Molina, Marian Fitzgibbon, Melissa A Simon, Lance Williams, Kameron Matthews, Jamie L Studts, Sarah E Lillie, Jamie S Ostroff, Lisa Carter-Harris, Robert A Winn
The Society of Behavioral Medicine (SBM) supports the United States Preventive Services Task Force (USPSTF) recommendation of low-dose computed tomography (LDCT) screening of the chest for eligible populations to reduce lung cancer mortality. Consistent with efforts to translate research findings into real-world settings, SBM encourages health-care providers and health-care systems to (1) integrate evidence-based tobacco treatment as an essential component of LDCT-based lung cancer screening, (2) examine the structural barriers that may impact screening uptake, and (3) incorporate shared decision-making as a clinical platform to facilitate consultations and engagement with individuals at high risk for lung cancer about the potential benefits and harms associated with participation in a lung cancer screening program...
September 19, 2016: Translational Behavioral Medicine
Jenifer I Fenton, Eric A Gurzell, Emily A Davidson, William S Harris
Numerous clinical trials examining the use of omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFAs) on various health outcomes have been conducted, and fish oil remains one of the most widely used nutritional supplements. More recently, studies have begun to utilize the omega-3 index, defined as the sum of EPA+DHA in red blood cells (RBCs), as both a biomarker of n-3 LCPUFA exposure and a potential risk factor for coronary heart disease (CHD). Considerably less research evaluates whether RBC phospholipid fatty acids reflect the phospholipid fatty acid composition of other tissues across increasing intakes of n-3 LCPUFAs...
September 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
William S Harris, Serge Masson, Simona Barlera, Valentina Milani, Silvana Pileggi, Maria Grazia Franzosi, Roberto Marchioli, Gianni Tognoni, Luigi Tavazzi, Roberto Latini
The Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico-Heart Failure (GISSI-HF) study reported benefits of n-3 fatty acid (FA) treatment on cardiovascular (CV) events, but the effects of treatment on a putative CV disease risk factor, the red blood cell (RBC) n-3 FA level (the omega-3 index), have not been examined in this context. We hypothesized that treatment with prescription omega-3 acid ethyl esters (O3AEE) would increase the omega-3 index to the proposed cardioprotective value of 8%...
September 2016: Nutrition Research
Nia M Harris, Rodney Ritzel, Nikolas Mancini, Yuhang Jiang, Xiang Yi, Devika S Manickam, William A Banks, Alexander V Kabanov, Louise D McCullough, Rajkumar Verma
BACKGROUND: Low levels of brain-derived neurotrophic factor (BDNF) are linked to delayed neurological recovery, depression, and cognitive impairment following stroke. Supplementation with BDNF reverses these effects. Unfortunately, systemically administered BDNF in its native form has minimal therapeutic value due to its poor blood brain barrier permeability and short serum half-life. In this study, a novel nano-particle polyion complex formulation of BDNF (nano-BDNF) was administered to mice after experimental ischemic stroke...
September 13, 2016: Pharmacology, Biochemistry, and Behavior
Praveen Surendran, Fotios Drenos, Robin Young, Helen Warren, James P Cook, Alisa K Manning, Niels Grarup, Xueling Sim, Daniel R Barnes, Kate Witkowska, James R Staley, Vinicius Tragante, Taru Tukiainen, Hanieh Yaghootkar, Nicholas Masca, Daniel F Freitag, Teresa Ferreira, Olga Giannakopoulou, Andrew Tinker, Magdalena Harakalova, Evelin Mihailov, Chunyu Liu, Aldi T Kraja, Sune Fallgaard Nielsen, Asif Rasheed, Maria Samuel, Wei Zhao, Lori L Bonnycastle, Anne U Jackson, Narisu Narisu, Amy J Swift, Lorraine Southam, Jonathan Marten, Jeroen R Huyghe, Alena Stančáková, Cristiano Fava, Therese Ohlsson, Angela Matchan, Kathleen E Stirrups, Jette Bork-Jensen, Anette P Gjesing, Jukka Kontto, Markus Perola, Susan Shaw-Hawkins, Aki S Havulinna, He Zhang, Louise A Donnelly, Christopher J Groves, N William Rayner, Matt J Neville, Neil R Robertson, Andrianos M Yiorkas, Karl-Heinz Herzig, Eero Kajantie, Weihua Zhang, Sara M Willems, Lars Lannfelt, Giovanni Malerba, Nicole Soranzo, Elisabetta Trabetti, Niek Verweij, Evangelos Evangelou, Alireza Moayyeri, Anne-Claire Vergnaud, Christopher P Nelson, Alaitz Poveda, Tibor V Varga, Muriel Caslake, Anton J M de Craen, Stella Trompet, Jian'an Luan, Robert A Scott, Sarah E Harris, David C M Liewald, Riccardo Marioni, Cristina Menni, Aliki-Eleni Farmaki, Göran Hallmans, Frida Renström, Jennifer E Huffman, Maija Hassinen, Stephen Burgess, Ramachandran S Vasan, Janine F Felix, Maria Uria-Nickelsen, Anders Malarstig, Dermot F Reilly, Maarten Hoek, Thomas F Vogt, Honghuang Lin, Wolfgang Lieb, Matthew Traylor, Hugh S Markus, Heather M Highland, Anne E Justice, Eirini Marouli, Jaana Lindström, Matti Uusitupa, Pirjo Komulainen, Timo A Lakka, Rainer Rauramaa, Ozren Polasek, Igor Rudan, Olov Rolandsson, Paul W Franks, George Dedoussis, Timothy D Spector, Pekka Jousilahti, Satu Männistö, Ian J Deary, John M Starr, Claudia Langenberg, Nick J Wareham, Morris J Brown, Anna F Dominiczak, John M Connell, J Wouter Jukema, Naveed Sattar, Ian Ford, Chris J Packard, Tõnu Esko, Reedik Mägi, Andres Metspalu, Rudolf A de Boer, Peter van der Meer, Pim van der Harst, Giovanni Gambaro, Erik Ingelsson, Lars Lind, Paul I W de Bakker, Mattijs E Numans, Ivan Brandslund, Cramer Christensen, Eva R B Petersen, Eeva Korpi-Hyövälti, Heikki Oksa, John C Chambers, Jaspal S Kooner, Alexandra I F Blakemore, Steve Franks, Marjo-Riitta Jarvelin, Lise L Husemoen, Allan Linneberg, Tea Skaaby, Betina Thuesen, Fredrik Karpe, Jaakko Tuomilehto, Alex S F Doney, Andrew D Morris, Colin N A Palmer, Oddgeir Lingaas Holmen, Kristian Hveem, Cristen J Willer, Tiinamaija Tuomi, Leif Groop, AnneMari Käräjämäki, Aarno Palotie, Samuli Ripatti, Veikko Salomaa, Dewan S Alam, Abdulla Al Shafi Majumder, Emanuele Di Angelantonio, Rajiv Chowdhury, Mark I McCarthy, Neil Poulter, Alice V Stanton, Peter Sever, Philippe Amouyel, Dominique Arveiler, Stefan Blankenberg, Jean Ferrières, Frank Kee, Kari Kuulasmaa, Martina Müller-Nurasyid, Giovanni Veronesi, Jarmo Virtamo, Panos Deloukas, Paul Elliott, Eleftheria Zeggini, Sekar Kathiresan, Olle Melander, Johanna Kuusisto, Markku Laakso, Sandosh Padmanabhan, David J Porteous, Caroline Hayward, Generation Scotland, Francis S Collins, Karen L Mohlke, Torben Hansen, Oluf Pedersen, Michael Boehnke, Heather M Stringham, Philippe Frossard, Christopher Newton-Cheh, Martin D Tobin, Børge Grønne Nordestgaard, Mark J Caulfield, Anubha Mahajan, Andrew P Morris, Maciej Tomaszewski, Nilesh J Samani, Danish Saleheen, Folkert W Asselbergs, Cecilia M Lindgren, John Danesh, Louise V Wain, Adam S Butterworth, Joanna M M Howson, Patricia B Munroe
High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ∼155,063 samples for independent replication. We identified 30 new blood pressure- or hypertension-associated genetic regions in the general population, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1...
October 2016: Nature Genetics
William S Harris
No abstract text is available yet for this article.
September 1, 2016: JAMA Internal Medicine
Steven M Horwitz, Andrew D Zelenetz, Leo I Gordon, William G Wierda, Jeremy S Abramson, Ranjana H Advani, C Babis Andreadis, Nancy Bartlett, John C Byrd, Luis E Fayad, Richard I Fisher, Martha J Glenn, Thomas M Habermann, Nancy Lee Harris, Francisco Hernandez-Ilizaliturri, Richard T Hoppe, Mark S Kaminski, Christopher R Kelsey, Youn H Kim, Susan Krivacic, Ann S LaCasce, Matthew Lunning, Auayporn Nademanee, Oliver Press, Rachel Rabinovitch, Nishitha Reddy, Erin Reid, Kenneth Roberts, Ayman A Saad, Lubomir Sokol, Lode J Swinnen, Julie M Vose, Joachim Yahalom, Nadeem Zafar, Mary Dwyer, Hema Sundar, Pierluigi Porcu
Peripheral T-cell lymphomas (PTCLs) represent a relatively uncommon heterogeneous group of non-Hodgkin's lymphomas (NHLs) with an aggressive clinical course and poor prognosis. Anthracycline-based multiagent chemotherapy with or without radiation therapy followed by first-line consolidation with high-dose therapy followed by autologous stem cell rescue (HDT/ASCR) is the standard approach to most of the patients with newly diagnosed PTCL. Relapsed or refractory disease is managed with second-line systemic therapy followed by HDT/ASCR or allogeneic stem cell transplant, based on the patient's eligibility for transplant...
September 2016: Journal of the National Comprehensive Cancer Network: JNCCN
Ligia F Martins, Juliana T Mesquita, Erika G Pinto, Thais A Costa-Silva, Samanta E T Borborema, Andres J Galisteo Junior, Bruno J Neves, Carolina H Andrade, Zainab Al Shuhaib, Elliot L Bennett, Gregory P Black, Philip M Harper, Daniel M Evans, Hisham S Fituri, John P Leyland, Claire Martin, Terence D Roberts, Andrew J Thornhill, Stephen A Vale, Andrew Howard-Jones, Dafydd A Thomas, Harri L Williams, Larry E Overman, Roberto G S Berlinck, Patrick J Murphy, Andre G Tempone
Synthetic analogues of marine sponge guanidine alkaloids showed in vitro antiparasitic activity against Leishmania (L.) infantum and Trypanosoma cruzi. Guanidines 10 and 11 presented the highest selectivity index when tested against Leishmania. The antiparasitic activity of 10 and 11 was investigated in host cells and in parasites. Both compounds induced depolarization of mitochondrial membrane potential, upregulation of reactive oxygen species levels, and increased plasma membrane permeability in Leishmania parasites...
September 23, 2016: Journal of Natural Products
Mandy L Harris, Katherine M Malloy, Sheena N Lawson, Rebecca S Rose, William F Buss, Ulrike Mietzsch
We aimed to decrease practice variation in treatment of neonatal status epilepticus by implementing a standardized protocol. Our primary goal was to achieve 80% adherence to the algorithm within 12 months. Secondary outcome measures included serum phenobarbital concentrations, number of patients progressing from seizures to status epilepticus, and length of hospital stay. Data collection occurred for 6 months prior and 12 months following protocol implementation. Adherence of 80% within 12 months was partially achieved in patients diagnosed in our hospital; in pretreated patients, adherence was not achieved...
August 31, 2016: Journal of Child Neurology
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