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Iron deficiency

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https://www.readbyqxmd.com/read/29777607/optimizing-charge-state-distribution-is-a-prerequisite-for-accurate-protein-biomarker-quantification-with-lc-ms-ms-as-illustrated-by-hepcidin-measurement
#1
Ellen M H Schmitz, Niels M Leijten, Joost L J van Dongen, Maarten A C Broeren, Lech G Milroy, Luc Brunsveld, Volkher Scharnhorst, Daan van de Kerkhof
BACKGROUND: Targeted quantification of protein biomarkers with liquid chromatography-tandem mass spectrometry (LC-MS/MS) has great potential, but is still in its infancy. Therefore, we elucidated the influence of charge state distribution and matrix effects on accurate quantification, illustrated by the peptide hormone hepcidin. METHODS: An LC-MS/MS assay for hepcidin, developed based on existing literature, was improved by using 5 mM ammonium formate buffer as mobile phase A and as an elution solution for solid phase extraction (SPE) to optimize the charge state distribution...
May 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29774023/ferritin-h-deficiency-in-myeloid-compartments-dysregulates-host-energy-metabolism-and-increases-susceptibility-to-mycobacterium-tuberculosis-infection
#2
Vineel P Reddy, Krishna C Chinta, Vikram Saini, Joel N Glasgow, Travis D Hull, Amie Traylor, Fernanda Rey-Stolle, Miguel P Soares, Rajhmun Madansein, Md Aejazur Rahman, Coral Barbas, Kievershen Nargan, Threnesan Naidoo, Pratistadevi K Ramdial, James F George, Anupam Agarwal, Adrie J C Steyn
Iron is an essential factor for the growth and virulence of Mycobacterium tuberculosis ( Mtb) . However, little is known about the mechanisms by which the host controls iron availability during infection. Since ferritin heavy chain (FtH) is a major intracellular source of reserve iron in the host, we hypothesized that the lack of FtH would cause dysregulated iron homeostasis to exacerbate TB disease. Therefore, we used knockout mice lacking FtH in myeloid-derived cell populations to study Mtb disease progression...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29773950/could-autism-be-associated-with-nutritional-status-in-the-palestinian-population-the-outcomes-of-the-palestinian-micronutrient-survey
#3
Mohammad Altamimi
Background: Autism spectrum disorder is a neurodevelopmental disorder. It is believed that the cause of autism is multifactorial, where genetic predispositions interact with environmental factors. In this context, micronutrients play a crucial role. Objective: To present evidence on current micronutrient status in Palestine and highlight its possible role in increasing problems of neurodevelopment disorders in general and autism in particular. Method: Analytical review of results...
2018: Nutrition and Metabolic Insights
https://www.readbyqxmd.com/read/29773197/efficient-zinc-uptake-is-critical-for-the-ability-of-pseudomonas-aeruginosa-to-express-virulence-traits-and-colonize-the-human-lung
#4
Maria Chiara Mastropasqua, Iain Lamont, Lois W Martin, David W Reid, Melania D'Orazio, Andrea Battistoni
We have recently shown that Pseudomonas aeruginosa, an opportunistic pathogen that chronically infects the lungs of patients with cystic fibrosis (CF) and other forms of lung disease, is extremely efficient in recruiting zinc from the environment and that this capability is required for its ability to cause acute lung infections in mice. To verify that P. aeruginosa faces zinc shortage when colonizing the lungs of human patients, we analyzed the expression of three genes that are highly induced under conditions of zinc deficiency (zrmA, dksA2 and rpmE2), in bacteria in the sputum of patients with inflammatory lung disease...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29772815/longitudinal-effects-of-iron-deficiency-anemia-and-subsequent-repletion-on-blood-parameters-and-the-rate-and-composition-of-growth-in-pigs
#5
Laura C Knight, Ryan N Dilger
Iron deficiency is reported as the most common nutrient deficiency worldwide. Due to rapid growth, infants are at particular risk for developing iron deficiency, which can easily progress to iron deficiency anemia (IDA), if not treated. The aim of this study was to determine the lasting effects of an early-life iron deficiency after a period of dietary iron repletion. Forty-two intact male pigs were fed, ad libitum , either control (CONT, 21.3 mg Fe/L) or iron-deficient (ID 2.72 mg Fe/L) milk replacer from postnatal day (PND) 2 to 32 (phase 1)...
May 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29772658/in-vitro-iron-bioavailability-of-brazilian-food-based-by-products
#6
Gabriela M Chiocchetti, Elisabete A De Nadai Fernandes, Anna A Wawer, Susan Fairweather-Tait, Tatiana Christides
Background : Iron deficiency is a public health problem in many low- and middle-income countries. Introduction of agro-industrial food by-products, as additional source of nutrients, could help alleviate this micronutrient deficiency, provide alternative sources of nutrients and calories in developed countries, and be a partial solution for disposal of agro-industry by-products. Methods : The aim of this study was to determine iron bioavailability of 5 by-products from Brazilian agro-industry (peels from cucumber, pumpkin, and jackfruit, cupuaçu seed peel, and rice bran), using the in vitro digestion/ Caco-2 cell model; with Caco-2 cell ferritin formation as a surrogate marker of iron bioavailability...
May 16, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29772478/bacillus-thuringiensis-cry5b-protein-as-a-new-pan-hookworm-cure
#7
Yan Hu, Thanh-Thanh Nguyen, Alice C Y Lee, Joseph F Urban, Melanie M Miller, Bin Zhan, David J Koch, Jason B Noon, Ambily Abraham, Ricardo Toshio Fujiwara, Dwight D Bowman, Gary R Ostroff, Raffi V Aroian
Hookworms are intestinal nematode parasites that infect nearly half a billion people and are globally one of the most important contributors to iron-deficiency anemia. These parasites have significant impacts in developing children, pregnant women and working adults. Of all the soil-transmitted helminths or nematodes (STNs), hookworms are by far the most important, with disease burdens conservatively estimated at four million DALYs (Disability-Adjusted Life Years) and with productivity losses of up to US$139 billion annually...
May 4, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29771935/cell-iron-status-influences-macrophage-polarization
#8
Rafiou Agoro, Meriem Taleb, Valerie F J Quesniaux, Catherine Mura
Macrophages play crucial roles in innate immune response and in the priming of adaptive immunity, and are characterized by their phenotypic heterogeneity and plasticity. Reprogramming intracellular metabolism in response to microenvironmental signals is required for M1/M2 macrophage polarization and function. Here we assessed the influence of iron on the polarization of the immune response in vivo and in vitro. Iron-enriched diet increased M2 marker Arg1 and Ym1 expression in liver and peritoneal macrophages, while iron deficiency decreased Arg1 expression...
2018: PloS One
https://www.readbyqxmd.com/read/29771368/restless-sleep-disorder-in-children-a-pilot-study-on-a-tentative-new-diagnostic-category
#9
Lourdes M DelRosso, Oliviero Bruni, Raffaele Ferri
Study Objectives: A group of children with "restless sleep" who do not fit the criteria for any other sleep disorder but with daytime impairment are studied to identify restless sleep disorder (RSD) clinically and polysomnographically and to differentiate it from other sleep disorders of childhood. Methods: A pilot study of 15 school aged children with restless sleep and 15 sex and age matched children with restless leg syndrome (RLS) and 37 normal controls were included...
May 16, 2018: Sleep
https://www.readbyqxmd.com/read/29769814/combined-deficiencies-of-25-hydroxyvitamin-d-and-anemia-in-preschool-children-with-severe-early-childhood-caries-a-case-control-study
#10
Shannon Deane, Robert J Schroth, Atul Sharma, Celia Rodd
Background: Severe early childhood caries (S-ECC) is common and has adverse affects on children's health. Children with S-ECC have been shown to have anemia or vitamin D deficiency. No studies have assessed the presence of combined deficiencies with S-ECC. The purpose of our study was to examine whether those with S-ECC had a higher prevalence of combined anemia and low 25-hydroxyvitamin D (25(OH)D) compared to controls. Covariates associated with elevated parathyroid hormone (PTH), previously noted in S-ECC, were examined...
May 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29769610/blsa-integrates-light-and-temperature-signals-into-iron-metabolism-through-fur-in-the-human-pathogen-acinetobacter-baumannii
#11
Marisel R Tuttobene, Pamela Cribb, María Alejandra Mussi
Light modulates global features of the important human pathogen Acinetobacter baumannii lifestyle including metabolism, tolerance to antibiotics and virulence, most of which depend on the short BLUF-type photoreceptor BlsA. In this work, we show that the ability to circumvent iron deficiency is also modulated by light at moderate temperatures, and disclose the mechanism of signal transduction by showing that BlsA antagonizes the functioning of the ferric uptake regulator (Fur) in a temperature-dependent manner...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29767836/how-do-we-manage-iron-deficiency-after-blood-donation
#12
REVIEW
Joseph E Kiss, Ralph R Vassallo
Blood donors and the RBCs and other components they willingly provide are essential in the delivery of healthcare in all parts of the world. Nearly 70% of donated blood comes from repeat or committed donors. The amount of iron removed in the 10 min or so it takes to withdraw a unit of blood (500 ml, plus 25 ml for testing) requires over 24 weeks to replace on a "standard" diet, i.e., without added iron in the form of supplements The cumulative effect of repeat blood donations without adequate iron replacement or a longer wait between donations results in iron deficiency (ID) in many donors, low haemoglobin deferral (~8% of donation attempts), and frank anaemia in some...
May 16, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29767699/impact-of-double-fortified-salt-with-iron-and-iodine-on-hemoglobin-anemia-and-iron-deficiency-anemia-a-systematic-review-and-meta-analysis
#13
María J Ramírez-Luzuriaga, Leila M Larson, Venkatesh Mannar, Reynaldo Martorell
Double-fortified salt (DFS) containing iron and iodine has been proposed as a feasible and cost-effective alternative for iron fortification in low- and middle-income countries (LMICs). We conducted a systematic review and meta-analysis from randomized and quasi-randomized controlled trials to 1) assess the effect of DFS on biomarkers of iron status and the risk of anemia and iron deficiency anemia (IDA) and 2) evaluate differential effects of DFS by study type (efficacy or effectiveness), population subgroups, iron formulation (ferrous sulfate, ferrous fumarate, and ferric pyrophosphate), iron concentration, duration of intervention, and study quality...
May 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29767675/a-comparison-of-methods-for-adjusting-biomarkers-of-iron-zinc-and-selenium-status-for-the-effect-of-inflammation-in-an-older-population-a-case-for-interleukin-6
#14
Sue O MacDonell, Jody C Miller, Michelle J Harper, Malcolm R Reid, Jillian J Haszard, Rosalind S Gibson, Lisa A Houghton
Background: Older people are at risk of micronutrient deficiencies, which can be under- or overestimated in the presence of inflammation. Several methods have been proposed to adjust for the effect of inflammation; however, to our knowledge, none have been investigated in older adults in whom chronic inflammation is common. Objective: We investigated the influence of various inflammation-adjustment methods on micronutrient biomarkers associated with anemia in older people living in aged-care facilities in New Zealand...
May 14, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29765934/autoimmune-gastritis-in-the-pediatric-age-an-underestimated-condition-report-of-two-cases-and-review
#15
Chiara Saglietti, Amedeo Sciarra, Karim Abdelrahman, Vanessa Schneider, Arti Karpate, Andreas Nydegger, Christine Sempoux
Background: Diagnosis of pediatric autoimmune gastritis (AIG) in children is important due to poor outcome and risk of malignancy. This condition is often underestimated in the clinico-pathologic diagnostic work-up, leading to delayed time-to-diagnosis. To increase the awareness of this condition in the pediatric population, we present two cases encountered at our institution, discuss their clinical, biological, and histological presentations in relation with evidence from the literature, and propose an algorithm for diagnosis and follow-up of AIG in children...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29764845/endoscopic-diagnosis-of-a-goblet-cell-carcinoid-tumour-of-the-appendix
#16
Vanessa Falk, Marcia Ballantyne, Sergio Zepeda-Gómez, Ali Kohansal-Vajargah
Primary malignancies of the appendix are rare. Of these, less than 5% are goblet cell carcinoid (GCC) tumours. The majority of GCC present with findings of acute appendicitis or advanced peritoneal spread. We describe a rare presentation of GCC as subtle mucosal abnormality of the appendiceal orifice seen on colonoscopy performed for iron-deficiency anaemia. Biopsies were interpreted as adenocarcinoma; however, final surgical pathology confirmed GCC of the appendix with caecal involvement. The patient recovered well from surgery, anaemia resolved and follow-up did not show metastatic disease...
May 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29761147/efficacy-of-long-term-oral-vitamin-b12-supplementation-after-total-gastrectomy-results-from-a-prospective-study
#17
Joana Moleiro, Susana Mão de Ferro, Sara Ferreira, Miguel Serrano, Margarida Silveira, António Dias Pereira
Background/Objectives: Vitamin B12 (VB12) deficiency is a common complication after total gastrectomy which may be associated with megaloblastic anemia and potentially irreversible neurologic symptoms. Intramuscular supplementation of VB12 has been considered the standard treatment, although it is associated with high costs and patient discomfort. Patients/Methods: We performed a prospective uncontrolled study (ACTRN12614000107628) in order to evaluate the clinical and laboratory efficacy of long-term oral VB12 supplementation in patients submitted to total gastrectomy...
April 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29760784/practical-guidance-for-the-management-of-iron-deficiency-in-patients-with-inflammatory-bowel-disease
#18
REVIEW
Dorothea Niepel, Thomas Klag, Nisar P Malek, Jan Wehkamp
Iron deficiency or iron deficiency anemia (IDA) are some of the most common systemic complications of inflammatory bowel diseases (IBD). Symptoms such as fatigue, reduced ability to concentrate and reduced exercise tolerance can mimic common symptoms of IBD and can therefore easily be overseen. Furthermore, clinicians tend to see mild to moderate anemia as an inevitable accompaniment of IBD that is sufficiently explained by the underlying disease and does not require further workup. But in contrast to these clinical routines, current guidelines recommend that any degree of anemia in patients with IBD should be further evaluated and treated...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29759803/reticulocyte-hemoglobin-content-mchr-in-the-assessment-of-iron-deficient-erythropoiesis-in-inflammatory-bowel-disease
#19
Eloísa Urrechaga, Johannes J M L Hoffmann, Antonio Bernal, Juan A Arévalo, José L Cabriada
BACKGROUND: In conditions associated with inflammation, biochemical parameters alone could be inadequate for assessing iron status. We investigated the potential utility of mean reticulocyte hemoglobin content (MCHr) in the assessment of the erythropoiesis status in inflammatory bowel disease (IBD). METHODS: We recruited 124 anemic outpatients with IBD. Serum iron, transferrin and ferritin were tested. Complete blood counts were performed on a CELL-DYN Sapphire analyzer (Abbott Diagnostics)...
April 22, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29759248/qualitative-and-quantitative-analysis-of-human-nails-to-find-correlation-between-nutrients-and-vitamin-d-deficiency-using-libs-and-icp-aes
#20
M A Almessiere, R Altuwiriqi, M A Gondal, R K AlDakheel, H F Alotaibi
In this work, we analysed human fingernails of people who suffer from vitamin D deficiency using the laser-induced breakdown spectroscopy(LIBS) and inductively coupled plasma atomic emission spectroscopy (ICP-AES)techniques. The measurements have been conducted on 71 nail samples collected randomly from volunteers of different genders and ages ranged between 20 and 50 years. The main aim of this study is to find the correlation between vitamin D deficiency and the intensity of some dominated lines in the LIBS spectra...
August 1, 2018: Talanta
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