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https://www.readbyqxmd.com/read/29329987/quantitative-proteomics-in-friedreich-s-ataxia-b-lymphocytes-a-valuable-approach-to-decipher-the-biochemical-events-responsible-for-pathogenesis
#1
Lorène Télot, Elodie Rousseau, Emmanuel Lesuisse, Camille Garcia, Bastien Morlet, Thibaut Léger, Jean-Michel Camadro, Valérie Serre
Friedreich's ataxia (FRDA) represents the most frequent type of autosomal-recessively inherited ataxia and is caused by the deficiency of frataxin, a mitochondrial protein. It is known that frataxin-deficiency leads to alterations in cellular and mitochondrial iron metabolism and impacts in the cell physiology at several levels. Frataxin is thought to play a role in iron-sulfur cluster biogenesis and heme synthesis. Currently, cellular antioxidant defense is dysregulated when frataxin is deficient, which exacerbates oxidative damage in FRDA...
January 9, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29329258/association-between-haem-and-non-haem-iron-intake-and-serum-ferritin-in-healthy-young-women
#2
Isabel Young, Helen M Parker, Anna Rangan, Tania Prvan, Rebecca L Cook, Cheyne E Donges, Kate S Steinbeck, Nicholas J O'Dwyer, Hoi Lun Cheng, Janet L Franklin, Helen T O'Connor
Iron is an essential micronutrient for human health and inadequate intake may result in iron deficiency (ID) or iron deficiency anaemia (IDA). Unlike other recent studies investigating iron status in young women, this cross-sectional study analysed dietary intake and biochemical data from healthy young (18-35 years) women (n = 299) to determine the association between both haem iron (HI) and non-haem iron (NHI) intakes and serum ferritin (SF). Dietary restraint and possible inflammation secondary to obesity were also measured and accounted for, and energy intake was adjusted for using the residuals method...
January 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29329244/infant-development-at-the-age-of-6-months-in-relation-to-feeding-practices-iron-status-and-growth-in-a-peri-urban-community-of-south-africa
#3
Marinel Rothman, Mieke Faber, Namukolo Covic, Tonderayi M Matsungo, Marike Cockeran, Jane D Kvalsvig, Cornelius M Smuts
BACKGROUND: Evidence on the association between feeding practices, iron deficiency, anaemia, stunting, and impaired psychomotor development during infancy is limited. This study assessed the association between psychomotor development with early feeding practices, growth, iron status, and anaemia. METHODS: This was cross-sectional baseline data of a randomised controlled trial which included 6-month-old infants and their mothers or primary caregivers (n = 750) in a peri-urban community in the North West province of South Africa...
January 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29328041/von-willebrand-factor-immunohistochemical-staining-quantitative-optical-density-parameters-in-the-endothelium-and-fibrinoid-of-the-placenta-during-secundines-inflammation-and-concomitant-iron-deficiency-anemia-in-gravidas
#4
V Ilika, I Davydenko
The aim of the research was to set the optical density quantitative parameters of the von Willebrand factor immunohistochemical staining (vWF) in the endothelium and fibrinoid of the placenta during the secundines inflammation concomitant with iron deficiency anemia in gravidas. The total number of 198 placentas was studied. The immunohistochemical technique was performed using the visualization of the primary antibodies to vWF with a diaminobenzidine dye polymer system. The optical density of the histochemical staining was measured by means of computer microdensitometry after the digital copies of the images had been obtained...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328038/quantitative-assessment-of-the-results-of-vimentin-immunohistochemical-examination-in-fibroblasts-and-endotheliocytes-of-the-placental-villi-in-the-aspect-of-preterm-maturation-of-the-chorionic-tree-and-iron-deficiency-anemia-of-gravidas
#5
О Garvasiuk, І Davydenko
The objective of our study was to investigate quantitative parameters of vimentin in fibroblasts and endotheliocytes of the chorionic villi by means of immunohistochemical examination of placenta with preterm maturation of the chorionic tree with iron-deficiency anemia of pregnancy in two different terms of gestation - 29-32 weeks and 33-36 weeks. 182 placentas were examined. The study design included two main groups of investigation of the above terms of gestation and three groups of comparison. Quantitative parameters of vimentin in the cytoplasm of fibroblasts and endotheliocytes of the placenta intermediate and terminal villi were considered on the basis of staining optic density measured by means of computer microdensitometry method...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29327790/iron-encapsulation-in-water-in-oil-emulsions-effect-of-ferrous-sulfate-concentration-and-fat-crystal-formation-on-oxidative-stability
#6
Nattapong Prichapan, David Julian McClements, Utai Klinkesorn
Iron deficiency is a major global human health concern. Encapsulation of iron in functional food products may help to solve this problem. However, iron is highly reactive and may promote rapid lipid oxidation in fatty foods. In this study, the effect of ferrous sulfate (0.1 to 0.5 wt%) and rice bran stearin (0 or 30 wt%) on the physical properties, oxidative stability, and encapsulation efficiency of 20 wt% water-in-oil (W/O) emulsions stabilized with polyglycerol polyricinoleate was investigated. In the presence of rice bran stearin crystals in the continuous oil phase, W/O emulsions had smaller mean droplet diameters (d ∼ 250 nm) and better physical stability than its absence (d ∼ 330 nm)...
January 12, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29327182/changes-in-iron-absorption-after-roux-en-y-gastric-bypass
#7
Wendy Schijns, Marjolein A P Ligthart, Frits J Berends, Ignace M C Janssen, Cees J H M van Laarhoven, Edo O Aarts, Hans de Boer
INTRODUCTION: Iron deficiency is one of the most common deficiencies that may occur after Roux-en-Y gastric bypass (RYGB). Little is known about the optimal treatment of post-RYGB iron deficiency. AIM: The aim of this study is to evaluate the changes in iron absorption characteristics after RYGB for two oral iron formulations, one presented in tablet form and one as in the form of a solution. METHOD: Iron absorption in 24 obese women was studied before and 1 month after RYGB...
January 11, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29326805/detection-of-%C3%AE-thalassemia-carriers-by-red-cell-parameters-obtained-from-automatic-counters-using-mathematical-formulas
#8
Idit Lachover Roth, Boaz Lachover, Guy Koren, Carina Levin, Luci Zalman, Ariel Koren
Background: β-thalassemia major is a severe disease with high morbidity. The world prevalence of carriers is around 1.5-7%. The present study aimed to find a reliable formula for detecting β-thalassemia carriers using an extensive database of more than 22,000 samples obtained from a homogeneous population of childbearing age women with 3161 (13.6%) of β-thalassemia carriers and to check previously published formulas. Methods: We applied a mathematical method based on the support vector machine (SVM) algorithm in the search for a reliable formula that can differentiate between thalassemia carriers and non-carriers, including normal counts or counts suspected to belong to iron-deficient women...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29324800/hepcidin-deficiency-and-iron-deficiency-do-not-alter-tuberculosis-susceptibility-in-a-murine-m-tb-infection-model
#9
Rachel Harrington-Kandt, Elena Stylianou, Lucy A Eddowes, Pei Jin Lim, Lisa Stockdale, Nawamin Pinpathomrat, Naomi Bull, Janet Pasricha, Marta Ulaszewska, Yulia Beglov, Sophie Vaulont, Hal Drakesmith, Helen McShane
Tuberculosis (TB), caused by the macrophage-tropic pathogen Mycobacterium tuberculosis (M.tb) is a highly prevalent infectious disease. Since an immune correlate of protection or effective vaccine have yet to be found, continued research into host-pathogen interactions is important. Previous literature reports links between host iron status and disease outcome for many infections, including TB. For some extracellular bacteria, the iron regulatory hormone hepcidin is essential for protection against infection...
2018: PloS One
https://www.readbyqxmd.com/read/29324643/nutritional-status-of-bariatric-surgery-candidates
#10
Aliaa Al-Mutawa, Alfred Kojo Anderson, Salman Alsabah, Mohammad Al-Mutawa
Obesity is a global epidemic affecting populations globally. Bariatric surgery is an effective treatment for morbid obesity, and has increased dramatically. Bariatric surgery candidates frequently have pre-existing nutritional deficiencies that might exacerbate post-surgery. To provide better health care management pre- and post-bariatric surgery, it is imperative to establish the nutritional status of prospective patients before surgery. The aim of this study was to assess and provide baseline data on the nutritional status of bariatric candidates...
January 11, 2018: Nutrients
https://www.readbyqxmd.com/read/29324251/potential-role-of-plasmodium-falciparum-exported-protein-1-in-the-chloroquine-mode-of-action
#11
Andreas Martin Lisewski, Joel Patrick Quiros, Monica Mittal, Nagireddy Putluri, Arun Sreekumar, Jesper Z Haeggström, Olivier Lichtarge
In the human malaria parasite Plasmodium falciparum, membrane glutathione S-transferases (GST) have recently emerged as potential cellular detoxifying units and as drug target candidates with the artemisinin (ART) class of antimalarials inhibiting their activity at single-digit nanomolar potency when activated by iron sources such as cytotoxic hematin. Here we put forward the hypothesis that the membrane GST Plasmodium falciparum exported protein 1 (PfEXP1, PF3D7_1121600) might be directly involved in the mode of action of the unrelated antimalarial 4-aminoquinoline drug chloroquine (CQ)...
December 27, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29322715/heart-failure-and-the-iron-deficiency
#12
Amey Beedkar, Rohan Parikh, Pradeep Deshmukh
Iron deficiency anemia is a significant problem worldwide and more so in developing countries, like India. The prevention and treatment of iron deficiency is a major public health goal in India It is now well recognized that iron deficiency has detrimental effects in patients with coronary artery disease, heart failure, and pulmonary hypertension, and possibly in patients undergoing cardiac surgery. Around one-third of all patients with HF, and around one-half of patients with pulmonary hypertension, are affected by iron deficiency...
November 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29322365/iron-pots-for-the-prevention-and-treatment-of-anemia-in-preschoolers
#13
Francisco Plácido Nogueira Arcanjo, Débora Rodrigues Ribeiro Macêdo, Paulo Roberto Santos, Caio Plácido Costa Arcanjo
OBJECTIVE: To assess the effect of food cooked in iron pots for the prevention and treatment of iron deficiency anemia. METHODS: In this cluster randomized clinical trial, authors evaluated preschoolers aged 4-5 y for 16 wk. Children were cluster randomized to either eating from iron pots (Group A) or aluminum pots (Group B). Primary outcome variables were change in hemoglobin concentration and anemia prevalence. Two biochemical evaluations were performed, to determine Hb concentrations, before and after intervention...
January 11, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29320750/the-many-faces-of-intestinal-tract-gastric-heterotopia-a-series-of-four-cases-highlighting-clinical-and-pathological-heterogeneity
#14
Aqsa Nasir, Stuart K Amateau, Sabina Khan, Ross W Simpson, Dale C Snover, Khalid Amin
Gastric heterotopia of the intestinal tract can have a diverse clinicopathologic presentation, resulting in a diagnostic dilemma. We present a series of four cases, two male and two female patients with age range of 31-82 year, found in the duodenum, jejunum, and transverse colon. The most common and rather unusual clinical presentation was iron deficiency anemia, seen in three cases, while one patient presented with abdominal pain. Endoscopically two cases were visualized as pedunculated polyps and two as sessile/plaques like lesions...
January 7, 2018: Human Pathology
https://www.readbyqxmd.com/read/29318945/relationship-between-obesity-and-iron-deficiency-anemia-is-there-a-role-of-hepcidin
#15
Ertan Sal, Idil Yenicesu, Nurullah Celik, Hatice Pasaoglu, Bulent Celik, Ozge Tugce Pasaoglu, Zühre Kaya, Ulker Kocak, Orhun Camurdan, Aysun Bideci, Peyami Cinaz
OBJECTIVES: Iron deficiency is common in obese children although the underlying mechanism is unclear. The aim of this study was to investigate the associations between iron parameters, leptin, hepcidin and adiponectin levels in obese children. METHODS: A total of 237 children, ranging in age from 5 to 18 years, 180 with primary obesity and 57 healthy children and adolescents, were enrolled. Complete blood count, serum iron levels, iron-binding capacity, ferritin levels, leptin, hepcidin and adiponectin levels were studied...
January 10, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29318944/prevalence-of-iron-deficiency-in-a-total-joint-surgery-population
#16
Jonathan H Waters, Peter Johnson, Mark H Yazer
BACKGROUND: Iron deficiency without anemia has been associated with decreases in functional work capacity and fatigue. The aim of this study was to determine the prevalence of iron deficiency without anemia in a preoperative cohort of orthopedic patients and to determine if iron deficiency is a condition which warrants inclusion into a prehabilitation program prior to surgery. METHODS: One hundred consecutive patients going through preoperative testing for total joint replacement were enrolled in the study...
January 10, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29313518/transferrin-and-lactoferrin-human-iron-sources-for-enterococci
#17
Paweł Lisiecki
To overcome limitations in iron acquisition, enterococci have evolved a number of mechanisms to scavenge iron from the host iron-binding proteins - transferrin (TR) and lactoferrin (LF). The aim of this study was to demonstrate the mechanisms by which enterococci utilize human TR and LF bound iron. The study included two strains of Enterococcus faecalis grown in iron-deficient and iron-excess media respectively. The binding activity of both proteins was monitored using proteins labelled with 125I. The uptake of iron by enterococci was determined using 59Fe labelled proteins...
December 4, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29313480/malaria-and-iron-load-at-the-first-antenatal-visit-in-the-rural-south-kivu-democratic-republic-of-the-congo-is-iron-supplementation-safe-or-could-it-be-harmful
#18
Esto Bahizire, Umberto D'Alessandro, Michèle Dramaix, Nicolas Dauby, Fabrice Bahizire, Kanigula Mubagwa, Philippe Donnen
We investigated the relationship between malaria infection and iron status in 531 pregnant women in South Kivu, Democratic Republic of the Congo. Sociodemographic data, information on morbidity, and clinical data were collected. A blood sample was collected at the first antenatal visit to diagnose malaria and measure serum ferritin (SF), soluble transferrin receptor, C-reactive protein, and α1-acid-glycoprotein. Malaria prevalence was 7.5%. Median (interquartile range) SF (adjusted for inflammation) was significantly higher in malaria-infected (82...
January 8, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29309374/evaluation-of-serum-trace-element-and-vitamin-levels-in-children-with-cancer-in-the-first-6-months-after-diagnosis
#19
Dilek Gurlek Gokcebay, Suna Emir, Turan Bayhan, Haci Ahmet Demir, Derya Ozyoruk, Mehmet Gunduz, Nevra Koc
Adequate nutrient intake should be provided for the cure of children diagnosed with cancer. The aim of this study was to evaluate serum trace elements and vitamins of children with cancer at diagnosis and during treatment. Children with newly diagnosed cancer who were admitted to our center were evaluated for serum selenium, iron, ferritin, C-reactive protein, vitamin B12, folate, and 25-OH vitamin D levels at presentation, and at the third and sixth months of cancer treatment. Forty-two children (male/female: 15/27) with a median age of 8 years (range, 2 to 17) were included in the study...
January 5, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29309373/a-mild-phenotype-of-severe-%C3%AE-thalassemia-in-a-16-month-old-boy
#20
Anthony O Akinbami, Amy E Sobota, Hong-Yuan Luo, David H K Chui, Martin H Steinberg
β thalassemia is characterized by a deficient production of functional β-globin chains and a relative excess of α-globin chains. An extremely diverse clinical spectrum-asymptomatic to transfusion-dependent-is primarily due to homozygosity or compound heterozygosity for the very large number of β-thalassemia-causing mutations, along with interacting mutations that affect the α-globin and γ-globin genes and their expression. We report a case of a 16-month-old boy who was initially diagnosed with iron deficiency anemia until he was later found to be homozygous for a severe β-thalassemia genotype with a mild hematologic phenotype...
January 5, 2018: Journal of Pediatric Hematology/oncology
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