Tobias Haase, Antje Ludwig, Anke Stach, Azadeh Mohtashamdolatshahi, Ralf Hauptmann, Lars Mundhenk, Harald Kratz, Susanne Metzkow, Avan Kader, Christian Freise, Susanne Mueller, Nicola Stolzenburg, Patricia Radon, Maik Liebl, Frank Wiekhorst, Bernd Hamm, Matthias Taupitz, Jörg Schnorr
Citrate-coated electrostatically stabilized very small superparamagnetic iron oxide particles (VSOPs) have been successfully tested as magnetic resonance angiography (MRA) contrast agents and are promising tools for molecular imaging of atherosclerosis. Their repeated use in the background of pre-existing hyperlipidemia and atherosclerosis has not yet been studied. This study aimed to investigate the effect of multiple intravenous injections of VSOPs in atherosclerotic mice. Taurine-formulated VSOPs (VSOP-T) were repeatedly intravenously injected at 100 µmol Fe/kg in apolipoprotein E-deficient (ApoE KO) mice with diet-induced atherosclerosis...
April 28, 2024: Nanomaterials