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https://www.readbyqxmd.com/read/28528394/a-novel-dual-wavelength-laser-stimulator-to-elicit-transient-and-tonic-nociceptive-stimulation
#1
Xiaoxi Dong, Tianjun Liu, Han Wang, Jichun Yang, Zhuying Chen, Yong Hu, Yingxin Li
This study aimed to develop a new laser stimulator to elicit both transient and sustained heat stimulation with a dual-wavelength laser system as a tool for the investigation of both transient and tonic experimental models of pain. The laser stimulator used a 980-nm pulsed laser to generate transient heat stimulation and a 1940-nm continuous-wave (CW) laser to provide sustained heat stimulation. The laser with 980-nm wavelength can elicit transient pain with less thermal injury, while the 1940-nm CW laser can effectively stimulate both superficial and deep nociceptors to elicit tonic pain...
May 20, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28527126/polycaprolactone-based-nanoparticles-loaded-with-indomethacin-for-anti-inflammatory-therapy-from-preparation-to-ex-vivo-study
#2
Waisudin Badri, Karim Miladi, Sophie Robin, Céline Viennet, Qand Agha Nazari, Géraldine Agusti, Hatem Fessi, Abdelhamid Elaissari
PURPOSE: This work focused on the preparation of polycaprolactone based nanoparticles containing indomethacin to provide topical analgesic and anti-inflammatory effect for symptomatic treatment of inflammatory diseases. Indomethacin loaded nanoparticles are prepared for topical application to decrease indomethacin side effects and administration frequency. Oppositely to already reported works, in this research non-invasive method has been used for the enhancement of indomethacin dermal drug penetration...
May 19, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28526914/finite-element-method-simulating-temperature-distribution-in-skin-induced-by-980-nm-pulsed-laser-based-on-pain-stimulation
#3
Han Wang, Xiao-Xi Dong, Ji-Chun Yang, He Huang, Ying-Xin Li, Hai-Xia Zhang
For predicting the temperature distribution within skin tissue in 980-nm laser-evoked potentials (LEPs) experiments, a five-layer finite element model (FEM-5) was constructed based on Pennes bio-heat conduction equation and the Lambert-Beer law. The prediction results of the FEM-5 model were verified by ex vivo pig skin and in vivo rat experiments. Thirty ex vivo pig skin samples were used to verify the temperature distribution predicted by the model. The output energy of the laser was 1.8, 3, and 4.4 J. The laser spot radius was 1 mm...
May 19, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28523497/maldi-msi-of-lipids-in-human-skin
#4
Philippa J Hart, Malcolm R Clench
Matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) is now a well-established technique for imaging analysis of sectioned biological tissues. One of the growing areas of interest is in the analysis of skin. MALDI-MSI can provide a wealth of information from within sections of skin. This includes information on the distribution of pharmaceuticals following topical treatments, through to the examination of the composition of different skin layers and studies of proteomic, lipidomic, and metabolomic responses to disease, wounds, and external stimuli...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28522423/sertaconazole-nitrate-loaded-nanovesicular-systems-for-targeting-skin-fungal-infection-in-vitro-ex-vivo-and-in-vivo-evaluation
#5
Menna M Abdellatif, Islam A Khalil, Mahmoud A F Khalil
The aim of this study was to develop different vesicular systems for sertaconazole nitrate and evaluate the ability of targeting deep skin layers to treat dermal fungal infection. Therefore, different phospholipid based nanovesicles, namely liposomes, glycerosomes, transferosmes and ethosomes were prepared and in-vitro evaluated for morphology, entrapment efficiency, vesicle size and zeta potential value, followed by ex-vivo evaluation through skin penetration and permeation. The selected vesicular formula was incorporated into gel base system and assessed by ex-vivo permeation visualization study using confocal laser scanning microscopy (CLSM)...
May 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28521901/noninvasive-imaging-analysis-of-biological-tissue-associated-with-laser-thermal-injury
#6
Cheng-Jen Chang, De-Yi Yu, Yen-Chang Hsiao, Kuang-Hua Ho
BACKGROUND: The purpose of our study is to use a noninvasive tomographic imaging technique with high spatial resolution to characterize and monitor biological tissue responses associated with laser thermal injury. METHODS: Optical doppler tomography (ODT) combines laser doppler flowmetry (LDF) with optical coherence tomography (OCT) to obtain high resolution tomographic velocity and structural images of static and moving constituents in highly scattering biological tissues...
April 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28521483/use-of-laser-capture-microdissection-allows-detection-of-loss-of-heterozygosity-in-chromosome-9p-in-breast-cancer
#7
Margarida Figueiredo Dias, Robert Blumenstein, Jose Russo
The present study was designed to determine whether loss of heterozygosity (LOH) in the p arm of chromosome 9 in invasive ductal carcinoma of the breast is detected during the neoplastic progression of the disease. Using laser capture microdissection (LCM) epithelial cells were isolated from 14 invasive ductal carcinoma cases (IDC), ductal carcinomas in situ (DCIS), normal mammary lobules, skin and/or lymph nodes of paraffin embedded tissue sections. LOH analysis of chromosome 9p was performed utilizing the microsatellite markers D9S199, D9S157, D9S171, D9S265 and D9S270...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28521102/co2-delivery-to-accelerate-incisional-wound-healing-following-single-irradiation-of-near-infrared-lamp-on-the-coordinated-colloids
#8
Wei-Peng Li, Chia-Hao Su, Sheng-Jung Wang, Fu-Ju Tsai, Chun-Ting Chang, Min-Chiao Liao, Chun-Chieh Yu, Thi-Tuong Vi Tran, Chaw-Ning Lee, Wen-Tai Chiu, Tak-Wah Wong, Chen-Sheng Yeh
Traditional wound care methods include wound infection control, adequate nutritional supplements, education of changing position every 2-3 h to avoid tissue hypoxia, vacuum assistant closure, debridement, skin graft, and tissue flap. Electric current stimulation, ultrasound, laser, and hydrotherapy have emerged as adjuvant therapies. However, most, if not all, of these therapies are expensive, and the treatment results are variable. The development of the active methods to improve wound healing is mandatory...
May 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28516802/the-influence-of-heating-on-toe-pressure-in-patients-with-peripheral-arterial-disease
#9
N Settembre, T Kagayama, P Kauhanen, P Vikatmaa, Y Inoue, M Venermo
BACKGROUND AND AIM: The toe skin temperature in vascular patients can be low, making reliable toe pressure measurements difficult to obtain. The aim of this study was to evaluate the effect of heating on the toe pressure measurements. MATERIALS AND METHODS: A total of 86 legs were examined. Brachial pressure and toe pressure were measured at rest in a supine position using a laser Doppler device that also measured skin temperature. After heating the toes for 5 min with a heating pad, we re-measured the toe pressure...
May 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28516571/fsoca-induced-switchable-footpad-skin-optical-clearing-window-for-blood-flow-and-cell-imaging-in%C3%A2-vivo
#10
Rui Shi, Wei Feng, Chao Zhang, Zhihong Zhang, Dan Zhu
The mouse footpad for its feature of hairlessness provides an available window for imaging vascular and cellular structure and function in vivo. Unfortunately, the strong scattering of its skin limits the penetration of light and reduces the imaging contrast and depth. Herein, an innovative footpad skin optical clearing agent (FSOCA) was developed to make the footpad skin transparent quickly by topical application. The results demonstrate that FSOCA treatment not only allowed the cutaneous blood vessels and blood flow distribution to be monitored by laser speckle contrast imaging technique with higher contrast, but also permitted the fluorescent cells to be imaged by laser scanning confocal microscopy with higher fluorescence signal intensity and larger imaging depth...
May 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28511158/evolution-of-some-indicators-of-systemic-immunity-in-patients-with-acne-while-using-laser-therapy
#11
Marianna Dashko, Orysya Syzon, Iryna Voznyak
INTRODUCTION: One of the important problems in modern dermatology is to improve treatment efficiency of acne being a common cause for cicatricial skin changes, loss of performance capability and social activity and negatively affects the psycho-emotional state of patients and their quality of life. The topicality of the disease is due to the high degree of its proliferation, chronic and recurrent course, and resistance to existing therapies. Reducing the effectiveness of skin diseases treatment, including that of acne, at present, is associated with developing resistance to drugs, which causes the use of non-drug methods in dermatology nowadays, including low-intensity laser therapy...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28508243/low-level-laser-treatment-stimulates-hair-growth-via-upregulating-wnt10b-and-%C3%AE-catenin-expression-in-c3h-hej-mice
#12
Tiran Zhang, Liqiang Liu, Jincai Fan, Jia Tian, Cheng Gan, Zengjie Yang, Hu Jiao, Bing Han, Zheng Liu
This study was conducted in order to evaluate the role of low-level laser treatment (LLLT) in hair growth in C3H/HeJ mice. Healthy C57BL/6 mice were randomly divided into two groups: with and without low-level laser treatment. The skin color of each mouse was observed each day. Skin samples were collected for H&E, immunofluorescence, PCR, and western blot analysis, to observe the morphology of hair follicles and detect the expression levels of Wnt10b and β-catenin. Observation of skin color demonstrated that black pigmentation started significantly earlier in the laser group than in the control group...
May 16, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28504937/ultrasonic-fingerprint-sensor-with-transmit-beamforming-based-on-a-pmut-array-bonded-to-cmos-circuitry
#13
Xiaoyue Jiang, Hao-Yen Tang, Yipeng Lu, Eldwin Ng, Julius Tsai, Bernhard Boser, David Horsley
In this paper, we present a single-chip 65x42 element ultrasonic pulse-echo fingerprint sensor with transmit beamforming based on piezoelectric micromachined ultrasonic transducers (PMUTs) directly bonded to a CMOS readout ASIC. The readout ASIC was realized in a standard 180 nm CMOS process with a 24V high voltage transistor option. Pulse-echo measurements are performed column-by-column in sequence using either one column or five columns to transmit the ultrasonic pulse at 20 MHz. Transmit beamforming is used to focus the ultrasonic beam at the imaging plane where the finger is located, increasing the ultrasonic pressure and narrowing the 3dB beam-width to 50 microns, a factor of 6...
May 11, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28504046/formulation-and-characterization-of-phospholipon%C3%A2-90%C3%A2-g-and-tween-%C3%A2-80-based-transfersomes-for-transdermal-delivery-of-eprosartan-mesylate
#14
Abdul Ahad, Abdulmohsen A Al-Saleh, Abdullah M Al-Mohizea, Fahad I Al-Jenoobi, Mohammad Raish, Alaa Eldeen B Yassin, Mohd Aftab Alam
The objective of the current study was to formulate the eprosartan mesylate loaded transfersomes using different proportions of Phospholipon(®) 90 G and Tween(®) 80 (95-75: 5-25% w/w). The prepared transfersomes were characterized for their vesicles size, shape, polydispersity index, zeta potential, entrapment efficiency, in vitro skin permeation, confocal laser scanning microscopy and in vivo skin irritation. Results revealed that the formulated transfersomes were negatively charged, spherical unilamellar structure of 71...
May 15, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28502717/preferential-accumulation-of-gold-nanorods-into-human-skin-hair-follicles-effect-of-nanoparticle-surface-chemistry
#15
Nouf N Mahmoud, Alaaldin M Alkilany, Dörthe Dietrich, Uwe Karst, Amal G Al-Bakri, Enam A Khalil
HYPOTHESIS: Gold nanoparticles (GNP) are considered an ideal model to help understanding the nano-skin interface. The surface functionality of gold nanorods (GNR) is expected to influence the uptake of nanoparticles into specific targets of skin such as hair follicles or dermis. Hence, it should be possible to modify the surface chemistry of GNP to achieve more targeted and safe skin therapy. EXPERIMENTS: GNR functionalized with various surface ligands (neutral, anionic, cationic, and hydrophobic) were evaluated for their accumulation into hair follicles of human skin sheets using ex-vivo setup...
May 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28500960/infrared-reflectometry-of-skin-analysis-of-backscattered-light-from-different-skin-layers
#16
Miguel A Pleitez, Otto Hertzberg, Alexander Bauer, Tobias Lieblein, Mathias Glasmacher, Hans Tholl, Werner Mäntele
We have recently reported infrared spectroscopy of human skin in vivo using quantum cascade laser excitation and photoacoustic or photothermal detection for non-invasive glucose measurement . Here, we analyze the IR light diffusely reflected from skin layers for spectral contributions of glucose. Excitation of human skin by an external cavity tunable quantum cascade laser in the spectral region from 1000 to 1245cm(-1), where glucose exhibits a fingerprint absorption, yields reflectance spectra with some contributions from glucose molecules...
May 1, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28498325/the-health-risk-of-cd-released-from-low-cost-jewelry
#17
Miloslav Pouzar, Magdalena Zvolská, Oldřich Jarolím, Lenka Audrlická Vavrušová
The composition of the surface layer of 13 low-cost jewelry samples with a high Cd content was analyzed using an energy-dispersive X-ray fluorescence spectrometer (ED XRF). The analyzed jewels were obtained in cooperation with the Czech Environmental Inspectorate. The jewels were leached in two types of artificial sweat (acidic and alkaline) for 7 days. Twenty microliters of the resulting solution was subsequently placed on a paper carrier and analyzed by an LIBS (Laser-Induced Breakdown Spectrometry) spectrometer after drying...
May 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28498204/asds-guidelines-task-force-consensus-recommendations-regarding-the-safety-of-lasers-dermabrasion-chemical-peels-energy-devices-and-skin-surgery-during-and-after-isotretinoin-use
#18
Abigail Waldman, Diana Bolotin, Kenneth A Arndt, Jeffrey S Dover, Roy G Geronemus, Anne Chapas, Sanjana Iyengar, Suzanne L Kilmer, Andrew C Krakowski, Naomi Lawrence, Heidi B Prather, Thomas E Rohrer, Bethanee J Schlosser, John Y S Kim, Peter R Shumaker, Leah K Spring, Murad Alam
BACKGROUND: Currently, the isotretinoin (13-cis-retinoic acid) package insert contains language advising the discontinuation of isotretinoin for 6 months before performing cosmetic procedures, including waxing, dermabrasion, chemical peels, laser procedures, or incisional and excisional cold-steel surgery. It is common practice to follow this standard because of concerns regarding reports of sporadic adverse events and increased risk of scarring. OBJECTIVE: To develop expert consensus regarding the safety of skin procedures, including resurfacing, energy device treatments, and incisional and excisional procedures, in the setting of concurrent or recent isotretinoin use...
May 10, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28498021/successful-treatment-of-becker-s-nevus-with-long-pulsed-1064nm-nd-yag-and-755nm-alexandrite-laser-and-review-of-the-literature
#19
Adam J Wulkan, Timothy McGraw, Mark Taylor
BACKGROUND: Becker's Nevus is an aesthetically troublesome condition secondary to hyperpigmentation and hypertrichosis. Although several lasers have been employed with varying degrees of success, the exact devices and treatment parameters have yet to be elucidated. OBJECTIVE: To assess the combination Nd:Yag and alexandrite laser as a safe and efficacious treatment for Becker's Nevus. METHODS: In a 20-year-old Fitzpatrick Skin Type IV male, a Becker's Nevus was treated with six sessions of long-pulsed 1,064nm Nd:Yag laser at six-week intervals followed by five sessions of long-pulsed 755nm alexandrite laser at three-month intervals...
May 12, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28497906/cytokine-profiling-analysis-following-a-non-ablative-fractional-laser-on-rat-skin
#20
Toshitatsu Nogita, Tatsuo Maeda, Tadashi Shimokata, Ryoji Tsuboi
No abstract text is available yet for this article.
February 2017: Journal of Dermatology
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