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https://www.readbyqxmd.com/read/28317530/depigmentation-therapies-for-vitiligo
#1
REVIEW
Pearl E Grimes, Rama Nashawati
The general goals of medical management of vitiligo are to repigment vitiliginous areas of skin and to stabilize the progression of depigmentation. However, for some patients with vitiligo affecting extensive body surface areas who are unresponsive to repigmentation therapies, depigmentation of the remaining normal skin may be a better choice. Candidates for depigmentation therapy should be carefully screened and patient education is essential. Permanent topical therapies used for depigmentation include monobenzyl ether of hydroquinone, 4-methoxyphenol, and 88% phenol...
April 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28317527/phototherapy-and-combination-therapies-for-vitiligo
#2
REVIEW
Samia Esmat, Rehab A Hegazy, Suzan Shalaby, Stephen Chu-Sung Hu, Cheng-Che E Lan
Vitiligo is a disease characterized by disappearance of melanocytes from the skin. It can negatively influence the physical appearance of affected individuals, and may profoundly affect a person's psychosocial function and quality of life. Therefore, vitiligo should not be considered as merely a condition that affects a patient's appearance, but needs to be actively treated in patients who seek medical help. Phototherapy has been used as the main treatment modality for patients with vitiligo. Different forms of phototherapy for vitiligo include broadband UVB, narrowband UVB, excimer light and excimer laser, and psoralen plus UVA...
April 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28317240/treatment-of-nevus-lipomatosus-cutaneous-superficialis-with-co2-laser
#3
Kabir Sardana, Shivani Bansal, Vijay K Garg, Nita Khurana
Nevus lipomatosus cutaneous superficialis (NLCS) is an uncommon lesion characterized by ectopic adipose tissue in the dermis and can be generalized or localized. It presents as a soft skin colored to yellowish papules or cerebriform plaques occurring usually on the buttock or thigh in a segment distribution. We report a case of NLCS in 38-year-old female, which was treated using the ultrapulse mode CO2 Laser. We describe the scientific logic and clinical results of using the ultrapulse mode in relation to the pathology of NLCS...
March 19, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28299865/novel-short-antimicrobial-peptide-isolated-from-xenopus-laevis-skin
#4
Yu Zhang, Songcai Liu, Siming Li, Yunyun Cheng, Linyan Nie, Gang Wang, Chen Lv, Wenzhen Wei, Cheng Cheng, Feng Hou, Linlin Hao
A rich source of bioactive peptides, including a large number of antimicrobial peptides, has been found in amphibian skin. In this study, a novel short antimicrobial peptide was purified from Xenopus laevis skin and characterised through reversed-phase high-performance liquid chromatography, Edman degradation and matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. The peptide was composed of six amino acids with a sequence of DEDLDE and thus named X. laevis antibacterial peptide-P2 (XLAsp-P2)...
March 16, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28299490/molecular-effects-of-fractional-ablative-erbium-yag-laser-treatment-with-multiple-stacked-pulses-on-standardized-human-three-dimensional-organotypic-skin-models
#5
Laurenz Schmitt, P M Amann, Y Marquardt, R Heise, K Czaja, P A Gerber, T Steiner, F Hölzle, Jens Malte Baron
The molecular changes in gene expression following ablative laser treatment of skin lesions, such as atrophic scars and UV-damaged skin, are not completely understood. A standardized in vitro model of human skin, to study the effects of laser treatment on human skin, has been recently developed. Therefore, the aim of the investigation was to examine morphological and molecular changes caused by fractional ablative erbium:YAG laser treatment on an in vitro full-thickness 3D standardized organotypic model of human skin...
March 15, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28299489/a-split-face-comparison-of-q-switched-nd-yag-1064-nm-laser-for-facial-rejuvenation-in-nevus-of-ota-patients
#6
Cao Yongqian, Lin Li, Bi Jianhai, Huo Ran, Guo Li, Wei Hao, Wang Xining, Xie Shigang, Wang Yibing
We aimed to investigate the efficacy and safety of using the 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (QSNYL) for skin rejuvenation in patients with Nevus of Ota. A retrospective, randomized, split-faced, clinical study was conducted. Twenty-nine patients with unilateral moderate to severe Nevus of Ota were enrolled. The participants completed 3-13 sessions of QSNYL treatments 3-6 months apart. Two independent physicians compared the treated and untreated sides of the face to evaluate the clearance of Nevus of Ota, the wrinkle severity rating scale (WSRS), the global aesthetic improvement scale (GAIS), and adverse event reporting...
March 15, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28298791/amyloidosis-and-anesthesia
#7
Zara Wani, Dev Kumar Harkawat, Meenaxi Sharma
AIM: The aim of this article is to provide a view of amyloidosis and discuss implications for the anesthetic management of patients with this condition. MATERIAL AND METHOD: Urine samples from patients with plasma cell dyscrasias were obtained from a urine bank that gathers urine samples from patients who gave research use consent for specimens that would otherwise be considered waste. RESULTS: Patients with amyloidosis may present to the anesthesiologist for procedures relating to diagnosis, surgery relating to the underlying condition (e...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28296509/tp53-and-atm-mrna-expression-in-skin-and-skeletal-muscle-after-low-level-laser-exposure
#8
Luciana Guedes de Almeida, Luiz Philippe da Silva Sergio, Flavia de Paoli, Andre Luiz Mencalha, Adenilson de Souza da Fonseca
Low-level lasers are widespread in regenerative medicine, but the molecular mechanisms involved in their biological effects are not fully understood, particularly those on DNA stability. Therefore, this study aimed to investigate mRNA expression of genes related to DNA genomic stability in skin and skeletal muscle tissue from Wistar rats exposed to low-level red and infrared lasers. For this, TP53 (Tumor Protein 53) and ATM (Ataxia Telangiectasia Mutated gene) mRNA expressions were evaluated by real-time quantitative PCR (RT-qPCR) technique 24 hours after low-level red and infrared laser exposure...
February 16, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28295755/evidence-for-a-functional-vasoconstrictor-role-for-atp-in-the-human-cutaneous-microvasculature
#9
James A Lang, Alex C Krajek, Kevin A Smaller
Noradrenaline is responsible for eliciting ∼60% of the reflex cutaneous vasoconstriction (VC) response in young adults, whereas the remainder is due to one or more unidentified coreleased sympathetic adrenergic neurotransmitter(s). Inconsistent evidence has placed neuropeptide Y in this role; however, other putative cotransmitters have yet to be tested. We hypothesize that ATP contributes to the reflex cutaneous VC response. Two protocols were conducted in young adults (n = 10); both involved the placement of three microdialysis (MD) probes in forearm skin and whole-body cooling (Tsk  = 30...
March 10, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28294694/the-effects-of-transcutaneous-and-intraoral-low-level-laser-therapy-after-extraction-of-lower-third-molars-a-randomized-single-blind-placebo-controlled-dual-center-study
#10
Sevil Altundag Kahraman, Sedat Cetiner, Robert A Strauss
OBJECTIVE AND BACKGROUND: The surgical removal of impacted third molars is one of the most common procedures performed by oral and maxillofacial surgeons. The purpose of this study is to determine whether either transcutaneous or intraoral low-level laser therapy (LLLT) reduces postoperative pain and assists in the healing of mandibular third molar extraction. MATERIALS AND METHODS: This randomized, placebo controlled, single-blind, split-mouth design study was conducted on 60 patients with full bony impacted similar position mandibular third molars bilaterally...
March 14, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28293809/a-mesenteric-traction-syndrome-affects-near-infrared-spectroscopy-evaluated-cerebral-oxygenation-because-skin-blood-flow-increases
#11
Niels D Olesen, Henrik Sørensen, Rikard Ambrus, Lars B Svendsen, Anton Lund, Niels H Secher
During abdominal surgery manipulation of internal organs may induce a "mesenteric traction syndrome" (MTS) including a triad of flushing, hypotension, and tachycardia that lasts for about 30 min. We evaluated whether MTS affects near-infrared spectroscopy (NIRS) assessed frontal lobe oxygenation (ScO2) by an increase in forehead skin blood flow (SkBF). The study intended to include 10 patients who developed MTS during pancreaticoduodenectomy and 22 patients were enrolled (age 61 ± 8 years; mean ± SD)...
March 14, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28293502/microvascular-fragment-transplantation-improves-rat-dorsal-skin-flap-survival
#12
Randolph Stone, Christopher R Rathbone
BACKGROUND: The development of flap necrosis distally remains a concern during microsurgical flap transfers because, at least in part, of decreased perfusion. Microvascular fragments (MVFs) are microvessels isolated from adipose tissue that are capable of improving tissue perfusion in a variety of tissue defects. The aim of this study was to determine whether the transplantation of MVFs in a dorsal rat skin flap model can improve flap survival. METHODS: A 10 × 3 cm flap was raised in a cranial to caudal fashion on the dorsal side of 16 Lewis rats, with the caudal side remaining intact...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28293107/nh4hco3-gas-generating-liposomal-nanoparticle-for-photoacoustic-imaging-in-breast-cancer
#13
Jizhu Xia, Gang Feng, Xiaorong Xia, Lan Hao, Zhigang Wang
In this study, we have developed a biodegradable nanomaterial for photoacoustic imaging (PAI). Its biodegradation products can be fully eliminated from a living organism. It is a gas-generating nanoparticle of liposome-encapsulating ammonium bicarbonate (NH4HCO3) solution, which is safe, effective, inexpensive, and free of side effects. When lasers irradiate these nanoparticles, NH4HCO3 decomposes to produce CO2, which can absorb much of the light energy under laser irradiation with a specific wavelength, and then expand under heat to generate a thermal acoustic wave...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28293102/paclitaxel-loaded-star-shaped-copolymer-nanoparticles-for-enhanced-malignant-melanoma-chemotherapy-against-multidrug-resistance
#14
Yongsheng Su, Jian Hu, Zhibin Huang, Yubin Huang, Bingsheng Peng, Ni Xie, Hui Liu
Malignant melanoma (MM) is the most dangerous type of skin cancer with annually increasing incidence and death rates. However, chemotherapy for MM is restricted by low topical drug concentration and multidrug resistance. In order to surmount the limitation and to enhance the therapeutic effect on MM, a new nanoformulation of paclitaxel (PTX)-loaded cholic acid (CA)-functionalized star-shaped poly(lactide-co-glycolide) (PLGA)-D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) nanoparticles (NPs) (shortly PTX-loaded CA-PLGA-TPGS NPs) was fabricated by a modified method of nanoprecipitation...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28288465/atlas-of-illustrative-cases-of-tattoo-complications
#15
Jørgen Serup
Tattoos, and tattoo complications as well, are colorful and visually flashy. A clinical outlook provides important clues to diagnosis by pattern recognition. This atlas,which is a report of 79 case illustrations, is made as a practical tool and vade mecum for the clinician. The atlas can be used in the office and as a bedside tool. It includes characteristic photos, and each case is accompanied with a brief medical history, a comment with learning points, the final diagnosis, and a review of therapeutic options...
2017: Current Problems in Dermatology
https://www.readbyqxmd.com/read/28288459/new-and-advanced-picosecond-lasers-for-tattoo-removal
#16
Maurice A Adatto, Ruthie Amir, Jayant Bhawalkar, Rafael Sierra, Richard Bankowski, Doran Rozen, Christine Dierickx, Moshe Lapidoth
Early methods of tattoo removal ultimately resulted in unacceptable cosmetic outcomes. While the introduction of laser technology was an improvement over the existing chemical, mechanical, and surgical procedures, the use of nonselective tattoo removal with carbon dioxide and argon lasers led to scarring. Q-switched lasers with nanosecond (10-9) pulse domains were considered to have revolutionized tattoo treatment, by selectively heating the tattoo particles, while reducing the adverse sequelae to adjacent normal skin...
2017: Current Problems in Dermatology
https://www.readbyqxmd.com/read/28288453/medical-treatment-of-tattoo-complications
#17
Jørgen Serup
Tattooing is a skin trauma and involves a special vulnus punctatum (with inserted tattoo ink, a vulnus venenatum), which should heal with no infection and no local complication. Local treatment in the healing phase ideally builds on the 'moist wound' principle using plastic film, hydrocolloids, silver dressing, and compression. Bacterial infections during healing are treated with oral antibiotics, and a list of first-line antibiotics is proposed. Notice is given to severe infections with affected general condition, and it is emphasized that intravenous antibiotic treatment must be instituted as early as possible to prevent septic shock and death...
2017: Current Problems in Dermatology
https://www.readbyqxmd.com/read/28288450/laser-treatment-of-tattoos-basic-principles
#18
Wolfgang Bäumler
Tattooing has become very popular worldwide during the past decades, and millions of people have one or many tattoos at different anatomical sites. The color of tattoos is mainly black, followed by red, green, blue, and other colors. A part of the tattooed people regret tattooing or have permanent problems with tattoos and therefore seek for tattoo removal. Tattoos consist of solid pigment particles in the skin. Thus, tattoo removal requires fragmentation of these permanently incorporated particles. The gold standard of tattoo removal is laser therapy...
2017: Current Problems in Dermatology
https://www.readbyqxmd.com/read/28286048/effect-of-age-on-cutaneous-vasomotor-responses-during-local-skin-heating
#19
Gary J Hodges, Matthew M Mallette, Garry A Tew, John M Saxton, James Moss, Alan D Ruddock, Markos Klonizakis
This study examined the effect of ageing on the low-frequency oscillations (vasomotion) of skin blood flow in response to local heating (LH). Skin blood flow was assessed by laser-Doppler flowmetry on the forearm at rest (33°C) and in response to LH of the skin to both 42°C and 44°C in 14 young (24±1years) and 14 older (64±1years) participants. Vasomotion was analyzed using a wavelet transform to investigate power of the frequency intervals associated with endothelial, neural, myogenic, respiratory, and cardiac activities of the laser-Doppler signal...
March 9, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28282557/the-effect-of-combined-photobiomodulation-and-metformin-on-open-skin-wound-healing-in-a-non-genetic-model-of-type-ii-diabetes
#20
Mohammadali Asghari, Ali Kanonisabet, Mandanad Safakhah, Zahra Azimzadeh, Ataroalsadat Mostafavinia, Abdollah Amini, Seyed Kamran Ghorishi, Reza JalaliFiroozkohi, Sahar Bayat, Mohammad Bayat
This study intended to examine the combined influences of photobiomodulation (PBM) and metformin on the microbial flora and biomechanical parameters of wounds in a non-genetic model of type II diabetes mellitus (TII DM). We induced a non-genetic model of TII DM in 20 rats by feeding them a 10% fructose solution for 2weeks followed by an injection of streptozotocin (STZ, 40mg/kg). After 21days from the injection of STZ, we induced one full-thickness skin wound in each of the diabetic rats. We randomly divided the rats into four groups: i) placebo; ii) pulsed wave laser (890nm, 80Hz, 0...
March 6, 2017: Journal of Photochemistry and Photobiology. B, Biology
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