Read by QxMD icon Read

Betaine AND methylation

Yun Hu, Qinwei Sun, Yan Hu, Zhen Hou, Yibo Zong, Nagmeldin A Omer, Halima Abobaker, Ruqian Zhao
Background: We have shown previously that in ovo betaine injection can prevent nonalcoholic fatty liver induced by glucocorticoid exposure in chickens; yet it remains unknown whether feeding betaine to laying hens may exert similar effects in their progeny. Objective: In this study, we fed laying hens a betaine-supplemented diet, and the progeny were later exposed chronically to corticosterone (CORT) to test hepatoprotective effects and further elucidate underlying mechanisms...
March 1, 2018: Journal of Nutrition
Esther Heid, Patricia A Hunt, Christian Schröder
Ground and excited state dipoles and polarizabilities of the chromophores N-methyl-6-oxyquinolinium betaine (MQ) and coumarin 153 (C153) in solution have been evaluated using time-dependent density functional theory (TD-DFT). A method for determining the atomic polarizabilities has been developed; the molecular dipole has been decomposed into atomic charge transfer and polarizability terms, and variation in the presence of an electric field has been used to evaluate atomic polarizabilities. On excitation, MQ undergoes very site-specific changes in polarizability while C153 shows significantly less variation...
March 15, 2018: Physical Chemistry Chemical Physics: PCCP
Ruey Leng Loo, Xin Zou, Lawrence J Appel, Jeremy K Nicholson, Elaine Holmes
Background: Interindividual variation in the response to diet is common, but the underlying mechanism for such variation is unclear. Objective: The objective of this study was to use a metabolic profiling approach to identify a panel of urinary metabolites representing individuals demonstrating typical (homogeneous) metabolic responses to healthy diets, and subsequently to define the association of these metabolites with improvement of risk factors for cardiovascular diseases (CVDs)...
March 1, 2018: American Journal of Clinical Nutrition
Sandra Tillmann, Hussain M Awwad, Amanda R Eskelund, Giulia Treccani, Juergen Geisel, Gregers Wegener, Rima Obeid
SCOPE: Probiotics may influence one-carbon (C1) metabolism, neurotransmitters, liver function markers, or behavior. METHODS AND RESULTS: Male adult Flinders Sensitive Line rats (model of depression, FSL; n = 22) received Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 (10 9 or 10 10 colony-forming units/d) or vehicle for 10 weeks. The controls, Flinders Resistant Line rats (FRL, n = 8), only received vehicle. C1-related metabolites were measured in plasma, urine, and different tissues...
February 17, 2018: Molecular Nutrition & Food Research
Zhen Hou, Qinwei Sun, Yun Hu, Shu Yang, Yibo Zong, Ruqian Zhao
As a feed additive, betaine is widely used in livestock production for its ability to promote growth. Our previous studies had reported that maternal betaine supplementation altered hepatic metabolism in offspring. But it remains unknown whether and how maternal betaine modulates metabolism of thyroid hormones in the offspring chickens by epigenetic modification. In this study, one hundred and twenty Rugao yellow-feathered laying hens were randomly divided into two groups, and were fed basal diet with or without 0...
February 13, 2018: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Valeria R Girardi, Juana J Silber, Ruben Darío Falcone, N Mariano Correa
In the present work we show how two biocompatible solvents, methyl laurate (ML) and isopropyl myristate (IPM), can be used as a less toxic alternative to replace the nonpolar component in a sodium 1,4-bis-2-ethylhexylsulfosuccinate (AOT) reverse micelles (RMs) formulation. In this sense, the micropolarity and the hydrogen-bond ability of the interface were monitored through the use of the solvatochromism of a molecular probe (1-methyl-8-oxyquinolinium betaine, QB) and Fourier transform infrared spectroscopy (FTIR)...
February 8, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Esther Heid, Christian Schröder
This study presents the large scale computer simulations of two common fluorophores, N-methyl-6-oxyquinolinium betaine and coumarin 153, in five polar or ionic solvents. The validity of linear response approximations to calculate the time-dependent Stokes shift is evaluated in each system. In most studied systems linear response theory fails. In ionic liquids the magnitude of the overall response is largely overestimated, and linear response theory is not able to capture the individual contributions of cations and anions...
February 5, 2018: Physical Chemistry Chemical Physics: PCCP
Huifang Kang, Zhiwang Zhang, Lin Yu, Yixing Li, Mingzhen Liang, Lei Zhou
Fat mass and obesity-associated protein (FTO) is a RNA demethylase, whether FTO regulates fat metabolism through its demethylation is unclear. The results of this study confirmed that N6-methyladenosine (m6 A) is associated with fat accumulation both in vivo and in vitro. The data showed that FTO down-regulated m6 A levels, decreased mitochondrial content, and increased triglyceride (TG) deposition. However, an FTO (R316A) mutant lacking demethylation activity could not regulate mitochondria and TG content, indicating that FTO affects mitochondrial content and fat metabolism by modulating m6 A levels in hepatocytes...
January 31, 2018: Journal of Cellular Biochemistry
Di Zhang, Huaijiang Jing, Changfeng Dou, Ling Zhang, Xiaoqing Wu, Qingqing Wu, Haoyang Song, Dengkun Li, Fengrui Wu, Yong Liu, Wenyong Li, Rong Wang
Mammal embryos can be impaired by mother's excessive ethanol uptake, which induces a higher level of reactive oxygen species (ROS) and interferes in one carbon unit metabolism. Here, our analysis by in vitro culture system reveals immediate effect of ethanol in medium on mouse embryo development presents concentration dependent. A preimplantation embryo culture using medium contained 1% ethanol could impact greatly early embryos development, and harmful effect of ethanol on preimplantation embryos would last during the whole development period including of reducing ratio of blastocyst formation and implantation, and deteriorating postimplantation development...
January 29, 2018: Scientific Reports
Shu Yang, Nannan Zhao, Yang Yang, Yun Hu, Haibo Dong, Ruqian Zhao
The growth-promoting action of betaine involves activation of GH/IGF-1 signaling, yet it remains unclear whether insulin-like growth factor 2 (IGF2), an imprinting gene, is affected by maternal dietary betaine supplementation. In this study, F1 offspring rats derived from dams fed basal or betaine-supplemented diet were examined at D21 and D63. Maternal betaine significantly upregulated the hepatic expression of IGF2 mRNA and protein in offspring rats at both D21 and D63, which was accompanied by enhanced hepatic IGF2 immunoreactivity and elevated serum IGF-2 level...
January 28, 2018: Journal of Agricultural and Food Chemistry
Nagmeldin A Omer, Yun Hu, Yan Hu, Abdulrahman A Idriss, Halima Abobaker, Zhen Hou, Haibo Dong, Ruqian Zhao
Background: Vitellogenin (VTG) is a precursor of egg yolk proteins synthesized within the liver of oviparous vertebrates. Betaine is an important methyl donor that is reported to improve egg production of laying hens with an unclear mechanism. In the present study, we fed betaine-supplemented diet (0.5%) to laying hens for 4 wk and investigated its effect on VTGII expression in the liver. Results: Betaine did not affect chicken weight, but significantly (P < 0...
2018: Journal of Animal Science and Biotechnology
Ciria G Figueroa-Soto, Elisa M Valenzuela-Soto
For many years, glycine betaine (GB) has been widely studied as an osmolyte in plants and bacteria. In animal cells, GB is an osmolyte mainly in the kidneys, but in humans many studies have shown its role as a methyl donor in homocysteine metabolism in the liver. GB is also a protein stabilizer, and thus, it became known as an osmoprotector. In many organisms GB is synthesized from choline and can also be obtained from some foods. Over the last twenty years GB has gone from being considered simply as an osmolyte to being known as a cytoprotector involved in cell metabolism and as a chemical chaperone...
January 20, 2018: Biochimie
Nannan Zhao, Shu Yang, Yimin Jia, Bo Sun, Bin He, Ruqian Zhao
There are lots of reports about alleviation of NAFLD by dietary supplements of betaine. However, it remains unclear whether maternal betaine supplementation can also ameliorate NAFLD in offspring. Hence, twenty pregnant rats were fed with a basal diet with or without betaine (1%), and then the female offspring rats were raised at 3 months of age followed by 3 weeks of physiological saline or dexamethasone in a dose of 0.1 mg/kg body mass every day via intraperitoneal injection. In this study, maternal betaine supplementation significantly (P<...
December 11, 2017: Journal of Nutritional Biochemistry
Kenneth R Eyring, Brent S Pedersen, Kenneth N Maclean, Sally P Stabler, Ivana V Yang, David A Schwartz
RATIONALE: Environmental exposures strongly influence the development and progression of asthma. We have previously demonstrated that mice exposed to a diet enriched with methyl donors during vulnerable periods of fetal development can enhance the heritable risk of allergic airway disease through epigenetic changes. There is conflicting evidence on the role of folate (one of the primary methyl donors) in modifying allergic airway disease. OBJECTIVES: We hypothesized that blocking folate metabolism through the loss of methylene-tetrahydrofolate reductase (Mthfr) activity would reduce the allergic airway disease phenotype through epigenetic mechanisms...
2018: PloS One
Abdulrahman A Idriss, Yun Hu, Zhen Hou, Yan Hu, Qinwei Sun, Nagmeldin A Omer, Halima Abobaker, Yingdong Ni, Ruqian Zhao
Betaine is widely used in animal nutrition to promote growth, development and methyl donor during methionine metabolism through nutritional reprogramming via regulation of gene expression. Prenatal betaine exposure is reported to modulate hypothalamic cholesterol metabolism in chickens, yet it remains unknown whether feeding hens with betaine-supplemented diet may affect hypothalamic cholesterol metabolism in F1 offspring. In this study, hens were fed with basal or betaine-supplemented (0.5%) for 30days, and the eggs were collected for incubation...
December 14, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Paulus S Rommer, Johannes Zschocke, Brian Fowler, Manuela Födinger, Vassiliki Konstantopoulou, Dorothea Möslinger, Elisabeth Stögmann, Erhard Suess, Matthias Baumgartner, Eduard Auff, Gere Sunder-Plassmann
BACKGROUND: Methylenetetrahydrofolate-reductase (MTHFR) deficiency is a rare autosomal recessive disorder affecting intracellular folate metabolism with affection of different organ systems and clinical manifestation usually in childhood. OBJECTIVE: We report on four adult members of a family with MTHFR deficiency presenting with neurological and thromboembolic complications in adulthood. METHODS: Extensive diagnostic work-up including genetic testing was performed in four adult members...
December 15, 2017: Journal of the Neurological Sciences
Ya-Yan Tong, Heng Zhang, Liang-Liang Chang, Xiao-Peng Xuan
In this work, two 1-carboxymethyl-1-methyl-pyrrolidinium bromides (N-methylpyrrolidine betaine hydrobromides) with the stoichiometry of betaine:hydrobromic acid as 1:1 and 2:1, denoted as CMPRHBr-I and CMPRHBr-II, respectively, were prepared and crystallographically determined. The large difference in these two structures is the type of hydrogen bonds, resulting in the different thermal stability. A strong OH⋯Br hydrogen bond was observed in CMPRHBr-I, whereas O⋯H⋯O hydrogen bond in CMPRHBr-II. Both these two crystals can mutually transform by changing the pH value of the aqueous solution...
November 28, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Haiying Wang, Bo Zhang, Xuechao Yan, Shuai Guo
Four pyridine-bridged bis(1,2,3-triazoles) A/B and C/D have been prepared by "click" reactions. Methylations/ethylations of A/B and C/D employing Meerwein's salts led to the formation of the corresponding dicationic salts 1/2 and 3/4 with pyridine moieties surviving from the alkylations. Interestingly, the reactions of "N-linked" salts 1/2 with K2CO3 in the presence of elemental sulfur did not yield the mesoionic carbene-sulfur betaine adducts but unexpectedly afforded 1,5-disubstituted triazoles 5/6, which may produce pyridine thioaldehydes as by-products...
December 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Sarah Young, Stephen Mason, Jeffery L Milleman, Kimberly R Milleman
PURPOSE: To investigate the stain-removal efficacy of an experimental ultra-low abrasivity anti-sensitivity dentifrice containing sodium tripolyphosphate (STP) and a cocamidopropyl betaine/sodium methyl cocoyl taurate detergent system. METHODS: This was a single-center, examiner-blind, randomized, parallel-group study. Extrinsic dental stain was assessed on the facial surfaces of the six maxillary and six mandibular anterior teeth and the lingual surfaces of the six mandibular anterior teeth using the Macpherson modification of the Lobene Stain Index (MLSI)...
October 2017: American Journal of Dentistry
Imtiaz Hussain Raja Abbasi, Farzana Abbasi, Rab N Soomro, Mohamed E Abd El-Hack, Mervat A Abdel-Latif, Wen Li, Ren Hao, Feifei Sun, Bello M Bodinga, Khawar Hayat, Junhu Yao, Yangchun Cao
During the transition period, fatty liver syndrome may be caused in cows undergo negative energy balance, ketosis or hypocalcemia, retained placenta or mastitis problems. During the transition stage, movement of non-esterified fatty acids (NEFA) increases into blood which declines the hepatic metabolism or reproduction and consequently, lactation performance of dairy cows deteriorates. Most of studies documented that, choline is an essential nutrient which plays a key role to decrease fatty liver, NEFA proportion, improve synthesis of phosphatidylcholine, maintain lactation or physiological function and work as anti-oxidant in the transition period of dairy cows...
November 25, 2017: AMB Express
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"