Zhi-Jun Yang, Si-Yu Huang, Kai-Yi Zhong, Wen-Ge Huang, Zi-Hui Huang, Tong-Tong He, Meng-Tao Yang, Maierhaba Wusiman, Dan-Dan Zhou, Si Chen, Bi-Xia Huang, Xiao-Lin Luo, Hua-Bin Li, Hui-Lian Zhu
Dementia, with homocysteine (Hcy) as an important risk factor, is a severe public health problem in the aging society. Betaine serves as a methyl donor and plays an important role in reducing Hcy. However, the effects and mechanisms of betaine on Hcy-induced cognitive impairment remain unclear. Firstly, SD rats were injected with Hcy (400 μg/kg) through vena caudalis, and betaine (2.5 % w/v) was supplemented via drinking water for 14 days. Betaine supplementation could attenuate Hcy-induced cognitive impairment in the Y maze and novel object recognition tests by repairing brain injury...
January 4, 2024: Redox Biology