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Aniqa B Alam, Estefania Toledo-Atucha, Dora Romaguera, Angel M Alonso-Gómez, Miguel A Martínez-Gonzalez, Lucas Tojal-Sierra, Cristina Razquin, Marta Noris Mora, Linzi Li, Vinita Subramanya, Jordi Salas-Salvadó, Montserrat Fitó, Alvaro Alonso
BACKGROUND: The effect of alcohol consumption on cardiovascular health, including atrial fibrillation risk, remains controversial. Evaluating the association of alcohol consumption with circulating atrial fibrillation-related biomarkers may help better understand the relevant mechanistic underpinnings. METHODS: We studied 523 participants from 3 sites for the PREDIMED-Plus study, a weight-loss randomized intervention trial in metabolically unhealthy adults. N-terminal pro-B-type natriuretic protein (NTproBNP), high sensitivity troponin-T (hsTnT), high-sensitivity C-reactive protein (hsCRP), 3-nitrotyrosine (3-NT), and procollagen type 1 carboxy-terminal propeptide (PICP) were measured in fasting serum samples at baseline and years 3 and 5 of follow-up...
December 5, 2023: medRxiv
#22
JOURNAL ARTICLE
Xavier Rossello, Raúl Ramallal, Dora Romaguera, Ángel M Alonso-Gómez, Alvaro Alonso, Lucas Tojal-Sierra, Carlos Fernández-Palomeque, Miguel Ángel Martínez-González, María Garrido-Uriarte, Luis López, Agnes Díaz, Olatz Zaldua-Irastorza, Amit J Shah, Jordi Salas-Salvadó, Montserrat Fitó, Estefania Toledo
AIMS: To evaluate the effect of an intensive lifestyle intervention (ILI) on the structural and functional cardiac substrate of atrial fibrillation (AF) in overweight or obese people with metabolic syndrome (MetS). METHODS: Participants of the PREDIMED-PLUS trial (n = 6874) were randomised 1:1 to an ILI program based on an energy-reduced Mediterranean diet, increased physical activity, and cognitive-behavioural weight management, or to a control intervention of low-intensity dietary advice...
December 15, 2023: European Journal of Preventive Cardiology
#23
JOURNAL ARTICLE
Jesús F García-Gavilán, Nancy Babio, Estefanía Toledo, Zhila Semnani-Azad, Cristina Razquin, Courtney Dennis, Amy Deik, Dolores Corella, Ramón Estruch, Emilio Ros, Montserrat Fitó, Fernando Arós, Miquel Fiol, José Lapetra, Rosa Lamuela-Raventos, Clary Clish, Miguel Ruiz-Canela, Miguel Ángel Martínez-González, Frank Hu, Jordi Salas-Salvadó, Marta Guasch-Ferré
BACKGROUND: Olive oil consumption has been inversely associated with the risk of type 2 diabetes (T2D) and cardiovascular disease (CVD). However, the impact of olive oil consumption on plasma metabolites remains poorly understood. This study aims to identify plasma metabolites related to total and specific types of olive oil consumption, and to assess the prospective associations of the identified multi-metabolite profiles with the risk of T2D and CVD. METHODS: The discovery population included 1837 participants at high cardiovascular risk from the PREvención con DIeta MEDiterránea (PREDIMED) trial with available metabolomics data at baseline...
December 13, 2023: Cardiovascular Diabetology
#24
JOURNAL ARTICLE
María Carmen Andreo-López, María Teresa Zarco-Martín, Victoria Contreras-Bolívar, María Luisa Fernández-Soto
BACKGROUND: Sarcopenia has recently been recognized as a complication of diabetes. However, there are few results about the prevalence of sarcopenia and dynapenia and the related clinical outcomes in type 1 diabetes mellitus (T1DM). Our objectives were to evaluate the prevalence of sarcopenia and dynapenia and to determine whether there are any associations with disease-related factors in people with T1DM. METHODS: A cross-sectional study was conducted in people with T1DM...
November 24, 2023: Nutrients
#25
JOURNAL ARTICLE
Inés Domínguez-López, Polina Galkina, Isabella Parilli-Moser, Camila Arancibia-Riveros, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Mireia Malcampo, J Alfredo Martínez, Lucas Tojal-Sierra, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J Tinahones, José Manuel Santos-Lozano, Lluís Serra-Majem, Aurora Bueno-Cavanillas, Josep A Tur, María Rubín-García, Xavier Pintó, Fernando Fernández-Aranda, Miguel Delgado-Rodríguez, Ana Barabash-Bustelo, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Estefania Toledo, Alessandro Atzeni, Eva M Asensio, Natàlia Vera, Antonio Garcia-Rios, Laura Torres-Collado, Napoleón Pérez-Farinós, Marian Zulet, Alice Chaplin, Rosa Casas, Sandra Martín-Peláez, Jessica Vaquero-Luna, Ana Maria Gómez-Pérez, Zenaida Vázquez-Ruiz, Sangeetha Shyam, Carolina Ortega-Azorín, Natàlia Talens, Patricia J Peña-Orihuela, Alejandro Oncina-Canovas, Javier Diez-Espino, Nancy Babio, Montserrat Fitó, Rosa M Lamuela-Raventós
SCOPE: Diets rich in polyphenols has been associated with better cognitive performance. The aim of this study is to assess the relationship between microbial phenolic metabolites (MPM) in urine and cognition in the context of an older population at high cardiovascular risk. METHODS AND RESULTS: A cross-sectional analysis is conducted in 400 individuals of the PREDIMED-Plus study. Liquid chromatography coupled to mass spectrometry is used to identify urinary MPM...
December 7, 2023: Molecular Nutrition & Food Research
#26
JOURNAL ARTICLE
Zhila Semnani-Azad, Estefanía Toledo, Nancy Babio, Miguel Ruiz-Canela, Clemens Wittenbecher, Cristina Razquin, Fenglei Wang, Courtney Dennis, Amy Deik, Clary B Clish, Dolores Corella, Montserrat Fitó, Ramon Estruch, Fernando Arós, Emilio Ros, Jesús García-Gavilan, Liming Liang, Jordi Salas-Salvadó, Miguel A Martínez-González, Frank B Hu, Marta Guasch-Ferré
BACKGROUND: Metabolic Syndrome (MetS) is a progressive pathophysiological state defined by a cluster of cardiometabolic traits. However, little is known about metabolites that may be predictors of MetS incidence or reversion. Our objective was to identify plasma metabolites associated with MetS incidence or MetS reversion. METHODS: The study included 1468 participants without cardiovascular disease (CVD) but at high CVD risk at enrollment from two case-cohort studies nested within the PREvención con DIeta MEDiterránea (PREDIMED) study with baseline metabolomics data...
November 24, 2023: Metabolism: Clinical and Experimental
#27
JOURNAL ARTICLE
David Murcia-Lesmes, Inés Domínguez-López, Emily P Laveriano-Santos, Anna Tresserra-Rimbau, Sara Castro-Barquero, Ramón Estruch, Zenaida Vazquez-Ruiz, Miguel Ruiz-Canela, Cristina Razquin, Dolores Corella, Jose V Sorli, Jordi Salas-Salvadó, Karla-Alejandra Pérez-Vega, Enrique Gómez-Gracia, José Lapetra, Fernando Arós, Miquel Fiol, Luis Serra-Majem, Xavier Pinto, Emilio Ros, Rosa M Lamuela-Raventós
AIMS: Clinical studies have produced conflicting evidence on the effects of the consumption of tomatoes on blood pressure, and there are limited data from epidemiologic studies. This study assesses whether tomato consumption (Solanum lycopersicum L.) is associated with Systolic (SBP) and Diastolic Blood Pressure (DBP), and the risk of hypertension in a prospective 3-year longitudinal study in older adults at high cardiovascular risk. METHODS: The present study was carried out within the PREDIMED (Prevención con Dieta Mediterránea) trial involving 7,056 (82...
November 24, 2023: European Journal of Preventive Cardiology
#28
JOURNAL ARTICLE
Claudia Vetrani, Ludovica Verde, Annamaria Colao, Luigi Barrea, Giovanna Muscogiuri
High adherence to the Mediterranean Diet (MD) is associated with a lower risk of type 2 diabetes. However, it is less clear whether the different MD food items might influence specific biological functions related to glucose tolerance, i.e., insulin resistance (IR) and/or secretion (IS). Thus, this cross-sectional study aimed to investigate the relationship between adherence to MD and IR, insulin sensitivity, and IS in individuals with overweight/obesity. Participants (62 individuals; 7M/55F; mean age 49 ± 15 years; mean BMI 35...
October 25, 2023: Nutrients
#29
JOURNAL ARTICLE
Indira Paz-Graniel, Jesús F García-Gavilán, Emilio Ros, Margery A Connelly, Nancy Babio, Christos S Mantzoros, Jordi Salas-Salvadó
BACKGROUND: The Mediterranean diet (MedDiet) has been related to a decreased risk of cardiovascular disease (CVD) and diabetes. OBJECTIVE: We aimed to prospectively assess the relationship between adherence to the MedDiet and advanced lipoprotein subclass profiles and glucose metabolism and inflammation markers, as determined by nuclear magnetic resonance spectroscopy (NMR). DESIGN: We conducted cross-sectional and longitudinal analyses within the framework of the PREDIMED study in 196 participants from the Reus-Tarragona center...
November 8, 2023: American Journal of Clinical Nutrition
#30
RANDOMIZED CONTROLLED TRIAL
Inés Domínguez-López, Rosa Casas, Gemma Chiva-Blanch, Miguel Ángel Martínez-González, Montserrat Fitó, Emilio Ros, Rosa M Lamuela-Raventós, Ramon Estruch
BACKGROUND & AIMS: Vitamin B12 plays a crucial role in cognition, but its effect might be regulated by the presence of other micronutrients, such as folate. The aim was to evaluate the effects of vitamin B12 on cognitive performance according to adherence to the Mediterranean diet, and whether the Mediterranean diet also results in increased folate or vitamin B12 levels. METHODS: This is a cohort study nested in a randomized controlled clinical trial performed in Hospital Clinic in Barcelona, Spain...
December 2023: Clinical Nutrition
#31
JOURNAL ARTICLE
Karima Sammoud, Zaynab Mahdi, Kamal Benzaida, Yassine Elrhaffouli, Maryame Yamlahi, Adil Gourinda, Faïza Charif, Fadila Bousgheiri, Hicham Elbouri, Najdi Adil
Background The Mediterranean diet (MD) has been recognized by several studies as beneficial for health improvement. The degree of adherence to this diet has also been evaluated using several scales, particularly time-consuming measures such as the Food Frequency Questionnaire (FFQ). This study aims to (a) adapt into Moroccan Arabic the 14-item Mediterranean Diet Adherence Screener (MEDAS), which is a simple and brief tool that assesses the degree of diet adherence and was used in the Prevencion con Dieta Mediterranea (PREDIMED) study, and (b) determine its psychometric properties...
September 2023: Curēus
#32
JOURNAL ARTICLE
Jadwiga Konieczna, Miguel Ruiz-Canela, Aina M Galmes-Panades, Itziar Abete, Nancy Babio, Miquel Fiol, Vicente Martín-Sánchez, Ramón Estruch, Josep Vidal, Pilar Buil-Cosiales, Jesús F García-Gavilán, Manuel Moñino, Alba Marcos-Delgado, Rosa Casas, Romina Olbeyra, Montserrat Fitó, Frank B Hu, Miguel Ángel Martínez-Gonzalez, J Alfredo Martínez, Dora Romaguera, Jordi Salas-Salvadó
IMPORTANCE: Strategies targeting body composition may help prevent chronic diseases in persons with excess weight, but randomized clinical trials evaluating lifestyle interventions have rarely reported effects on directly quantified body composition. OBJECTIVE: To evaluate the effects of a lifestyle weight-loss intervention on changes in overall and regional body composition. DESIGN, SETTING, AND PARTICIPANTS: The ongoing Prevención con Dieta Mediterránea-Plus (PREDIMED-Plus) randomized clinical trial is designed to test the effect of the intervention on cardiovascular disease prevention after 8 years of follow-up...
October 2, 2023: JAMA Network Open
#33
JOURNAL ARTICLE
Fernando J Ribeiro, Raquel Teixeira, Rui Poínhos
As the esports industry grows, marketing campaigns for fast food, soft drinks, alcoholic and energy drinks, and dietary supplements at related events intensify. Portuguese and Brazilian esports players' dietary patterns remain unexplored. This study aimed to characterize the dietary and gaming habits of esports players. We applied an anonymous, open online survey to a convenience sample of esports players that included the PREDIMED and the Internet Gaming Disorder Scale. The survey was shared through email and social media platforms, including Facebook, Twitter, Instagram, Discord, WhatsApp, and Twitch...
September 28, 2023: Nutrients
#34
JOURNAL ARTICLE
Sangeetha Shyam, Jesús Francisco García-Gavilán, Indira Paz-Graniel, José J Gaforio, Miguel Ángel Martínez-González, Dolores Corella, J Alfredo Martínez, Ángel M Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J Tinahones, José Lapetra, J Luís Serra-Majem, Aurora Bueno-Cavanillas, Josep A Tur, Vicente Martín Sánchez, Xavier Pintó, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Fernando Fernandez-Aranda, Stephanie K Nishi, Oscar Garcia-Regata, Estefania Toledo, Eva M Asensio, Olga Castañer, Antonio Garcia-Rios, Laura Torres-Collado, Enrique Gómez-Gracia, M Angeles Zulet, Nuria Goñi Ruiz, Rosa Casas, Naomi Cano-Ibáñez, Lucas Tojal-Sierra, A M Gómez-Perez, Jose V Sorlí, Sergio Cinza-Sanjurjo, Sandra Martín-Peláez, Patricia J Peña-Orihuela, Alejandro Oncina-Canovas, Rafael Perez-Araluce, María Dolores Zomeño, Alice Chaplin, Miguel Delgado-Rodríguez, Nancy Babio, Montserrat Fitó, Jordi Salas-Salvadó
BACKGROUND: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. METHODS: This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction...
October 13, 2023: BMC Medicine
#35
REVIEW
Constantine Tarabanis, Clarine Long, Bianca Scolaro, Sean P Heffron
AIMS: We reviewed the literature to date for high-level evidence on the cardiovascular and other health effects of olive oil with a focus on the amount, frequency of use and type of olive oil consumed in prior studies. A total of twelve prospective cohort studies with sample sizes of at least 4000 individuals and one meta-analysis were identified. DATA SYNTHESIS: The majority of cohorts followed individuals aged ≥55 years old, free of cardiovascular disease (CVD) at baseline but at high risk, over periods of 4-10 years and with daily consumption amounts of 10-35 g/day...
August 26, 2023: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
#36
JOURNAL ARTICLE
Miguel A Martínez-González, Pedro Montero, Miguel Ruiz-Canela, Estefanía Toledo, Ramón Estruch, Enrique Gómez-Gracia, Jun Li, Emilio Ros, Fernando Arós, Alvaro Hernáez, Dolores Corella, Miquel Fiol, José Lapetra, Lluis Serra-Majem, Xavier Pintó, Montse Cofán, José V Sorlí, Nancy Babio, Yolanda F Márquez-Sandoval, Olga Castañer, Jordi Salas-Salvadó
BACKGROUND: Several large observational prospective studies have reported a protection by the traditional Mediterranean diet against type 2 diabetes, but none of them used yearly repeated measures of dietary intake. Repeated measurements of dietary intake are able to improve subject classification and to increase the quality of the assessed relationships in nutritional epidemiology. Beyond observational studies, randomized trials provide stronger causal evidence. In the context of a randomized trial of primary cardiovascular prevention, we assessed type 2 diabetes incidence according to yearly repeated measures of compliance with a nutritional intervention based on the traditional Mediterranean diet...
September 29, 2023: Cardiovascular Diabetology
#37
JOURNAL ARTICLE
Luigi Barrea, Ludovica Verde, Daniel Simancas-Racines, Ana Karina Zambrano, Evelyn Frias-Toral, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri
BACKGROUND: The terms metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) categorize subjects with obesity based on the presence or absence of cardio-metabolic risk factors. Detecting MUO phenotype is crucial due to the high risk of cardio-metabolic complications, requiring tailored and intensive follow-up. However, diagnosing MUO is time-consuming and costly. Thus, we aimed to investigate the role of Mediterranean diet (MD) in determining MHO/MUO phenotypes and whether adherence to MD could serve as an additional screening tool for MUO phenotype...
September 28, 2023: Journal of Translational Medicine
#38
JOURNAL ARTICLE
Sandra García-Mateo, Samuel J Martínez-Domínguez, Carla Jerusalén Gargallo-Puyuelo, María Teresa Arroyo Villarino, Viviana Laredo De La Torre, Beatriz Gallego, Erika Alfambra, Fernando Gomollón
Inflammatory bowel diseases (IBDs) are associated with an increased risk of metabolic comorbidities. There is a lack of data regarding the relationship between lifestyle and metabolic diseases in IBD patients. A cross-sectional study on consecutive IBD outpatients was conducted. Adherence to the Mediterranean diet (MD) was assessed using a 14-item questionnaire from the PREDIMED study, and physical activity was evaluated using the GODIN-Leisure score. Body composition was studied based on body mass index and waist-hip ratio (WHR), while quality of life was assessed using a nine-item short questionnaire...
September 14, 2023: Nutrients
#39
JOURNAL ARTICLE
Santiago Rios, Jesús F García-Gavilán, Nancy Babio, Indira Paz-Graniel, Miguel Ruiz-Canela, Liming Liang, Clary B Clish, Estefania Toledo, Dolores Corella, Ramón Estruch, Emilio Ros, Montserrat Fitó, Fernando Arós, Miquel Fiol, Marta Guasch-Ferré, José M Santos-Lozano, Jun Li, Cristina Razquin, Miguel Ángel Martínez-González, Frank B Hu, Jordi Salas-Salvadó
BACKGROUND: A healthy lifestyle (HL) has been inversely related to type 2 diabetes (T2D) and cardiovascular disease (CVD). However, few studies have identified a metabolite profile associated with HL. The present study aims to identify a metabolite profile of a HL score and assess its association with the incidence of T2D and CVD in individuals at high cardiovascular risk. METHODS: In a subset of 1833 participants (age 55-80y) of the PREDIMED study, we estimated adherence to a HL using a composite score based on the 2018 Word Cancer Research Fund/American Institute for Cancer Research recommendations...
September 16, 2023: Cardiovascular Diabetology
#40
JOURNAL ARTICLE
Carolyn J English, Anna E Lohning, Hannah L Mayr, Mark Jones, Helen MacLaughlin, Dianne P Reidlinger
Healthy dietary patterns are associated with lower inflammation and cardiovascular disease (CVD) risk and adherence can be measured using diet quality scores. Inflammation is traditionally measured with C-reactive protein (hsCRP), however there is interest in novel pro-inflammatory markers platelet-activating factor (PAF) and lipoprotein-associated phospholipase A2 (Lp-PLA2 ) that are specifically involved in endothelial dysfunction and inflammation. This cross-sectional study investigated the association between PAF, Lp-PLA2 , hsCRP, and six diet scores...
September 12, 2023: Nutrition & Metabolism
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