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https://www.readbyqxmd.com/read/28427311/feasibility-and-acceptability-of-a-clinic-based-mediterranean-style-diet-intervention-to-reduce-cardiovascular-risk-for-hispanic-americans-with-type-2-diabetes
#1
Laura Cubillos, Yanire Estrada Del Campo, Khalil Harbi, Thomas Keyserling, Carmen Samuel-Hodge, Daniel S Reuland
Purpose The purpose of the study was to modify a previously tested Spanish language version of a Mediterranean (Med)-style dietary intervention so that the dietary recommendations align with the cultural and social needs of Hispanic Americans (HAs) with type 2 diabetes (T2D) and evaluate the modified intervention's feasibility and acceptability. Methods In phase I (formative), semi-structured interviews and focus groups were used to refine the intervention content and format for delivery to HAs with T2D receiving care at a large primary care practice...
April 1, 2017: Diabetes Educator
https://www.readbyqxmd.com/read/28415042/determinants-of-increasing-serum-pops-in-a-population-at-high-risk-for-cardiovascular-disease-results-from-the-predimed-canarias-study
#2
Luis A Henríquez-Hernández, Octavio P Luzardo, Manuel Zumbado, Lluis Serra-Majem, Pilar F Valerón, María Camacho, Jacqueline Álvarez-Pérez, Jordi Salas-Salvadó, Luis D Boada
Persistent organic pollutants (POPs) are well-known ubiquitous environmental chemicals which have been related to adverse health outcomes, including cardiovascular disease (CVD). The purpose of this study was to evaluate POPs burden, and its determinants, in a population at high risk of suffering CVD enrolled in the PREDIMED Study (Spanish acronym for PREvention by means of MEDiterranean Diet). This cohort was formed by 343 participants (55-80 y.o.), which were selected for a preventive nutritional intervention for CVD based on the Mediterranean Diet...
April 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28392547/chromium-exposure-and-risk-of-cardiovascular-disease-in-high-cardiovascular-risk-subjects%C3%A3-nested-case-control-study-in-the-prevention-with-mediterranean-diet-predimed-study
#3
Mario Gutiérrez-Bedmar, Miguel Ángel Martínez-González, Carlos Muñoz-Bravo, Miguel Ruiz-Canela, Alberto Mariscal, Jordi Salas-Salvadó, Ramón Estruch, Dolores Corella, Fernando Arós, Monserrat Fito, José Lapetra, Lluís Serra-Majem, Xavier Pintó, Ángel Alonso-Gómez, Olga Portoles, Miquel Fiol, Mónica Bulló, Olga Castañer, Emilio Ros, Enrique Gómez-Gracia
BACKGROUND: Epidemiological data on chromium (Cr) exposure and the risk of cardiovascular disease (CVD) are still limited. Toenail Cr level (TCL) provides a time-integrated measure reflecting long-term Cr exposure. We measured TCL to assess the hypothesis that long-term Cr exposure was inversely associated with incident CVD in a population at high risk for CVD.Methods and Results:The associations between TCL and CVD were evaluated in a case-control study nested within the "PREvención con DIeta MEDiterránea" (PREDIMED) trial...
April 8, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28392166/legume-consumption-is-inversely-associated-with-type-2-diabetes-incidence-in-adults-a-prospective-assessment-from-the-predimed-study
#4
Nerea Becerra-Tomás, Andrés Díaz-López, Núria Rosique-Esteban, Emilio Ros, Pilar Buil-Cosiales, Dolores Corella, Ramon Estruch, Montserrat Fitó, Lluís Serra-Majem, Fernando Arós, Rosa Maria Lamuela-Raventós, Miquel Fiol, José Manuel Santos-Lozano, Javier Díez-Espino, Olga Portoles, Jordi Salas-Salvadó
BACKGROUND & AIMS: Legumes, a low-energy, nutrient-dense and low glycemic index food, have shown beneficial effects on glycemic control and adiposity. As such, legumes are widely recommended in diabetic diets, even though there is little evidence that their consumption protects against type 2 diabetes. Therefore the aim of the present study was to examine the associations between consumption of total legumes and specific subtypes, and type 2 diabetes risk. We also investigated the effect of theoretically substituting legumes for other protein- or carbohydrate-rich foods...
March 24, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28371298/the-mediterranean-diet-decreases-ldl-atherogenicity-in-high-cardiovascular-risk-individuals-a-randomized-controlled-trial
#5
Álvaro Hernáez, Olga Castañer, Alberto Goday, Emilio Ros, Xavier Pintó, Ramón Estruch, Jordi Salas-Salvadó, Dolores Corella, Fernando Arós, Lluis Serra-Majem, Miguel Ángel Martínez-González, Miquel Fiol, José Lapetra, Rafael de la Torre, M Carmen López-Sabater, Montserrat Fitó
SCOPE: Traditional Mediterranean Diet (TMD) protects against cardiovascular disease through several mechanisms such as decreasing LDL cholesterol levels. However, evidence regarding TMD effects on LDL atherogenic traits (resistance against oxidation, size, composition, cytotoxicity) is scarce. METHODS AND RESULTS: We assessed the effects of a 1-year intervention with a TMD on LDL atherogenic traits in a random sub-sample of individuals from the PREDIMED Study (N = 210)...
April 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28323949/plasma-arginine-asymmetric-dimethylarginine-ratio-and-incidence-of-cardiovascular-events-a-case-cohort-study
#6
Edward Yu, Miguel Ruiz-Canela, Frank B Hu, Clary B Clish, Dolores Corella, Jordi Salas-Salvadó, Adela Hruby, Montserrat Fitó, Liming Liang, Estefania Toledo, Emilio Ros, Ramón Estruch, Enrique Gómez-Gracia, Jose Lapetra, Fernando Arós, Dora Romaguera, Lluís Serra-Majem, Marta Guasch-Ferré, Dong D Wang, Miguel A Martínez-González
CONTEXT: Arginine, its methylated metabolites and other metabolites related to the urea cycle have been independently associated with cardiovascular risk, but the potential causal meaning of these associations (positive for some metabolites and negative for others) remains elusive due to a lack of studies measuring metabolite changes over time. OBJECTIVE: To examine the association between baseline and 1-year concentrations of urea cycle metabolites and cardiovascular disease in a case-cohort setting...
March 2, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28288977/prediction-of-cardiovascular-disease-by-the-framingham-regicor-equation-in-the-high-risk-predimed-cohort-impact-of-the-mediterranean-diet-across-different-risk-strata
#7
Antonio J Amor, Mercè Serra-Mir, Miguel A Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Montserrat Fitó, Ramón Estruch, Lluis Serra-Majem, Fernando Arós, Nancy Babio, Emilio Ros, Emilio Ortega
BACKGROUND: The usefulness of cardiovascular disease (CVD) predictive equations in different populations is debatable. We assessed the efficacy of the Framingham-REGICOR scale, validated for the Spanish population, to identify future CVD in participants, who were predefined as being at high-risk in the PREvención con DIeta MEDiterránea (PREDIMED) study-a nutrition-intervention primary prevention trial-and the impact of adherence to the Mediterranean diet on CVD across risk categories...
March 13, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28276290/dietary-energy-density-and-body-weight-changes-after-3-years-in-the-predimed-study
#8
Cristina Razquin, Ana Sanchez-Tainta, Jordi Salas-Salvadó, Pilar Buil-Cosiales, Dolores Corella, Montserrat Fito, Emilio Ros, Ramón Estruch, Fernando Arós, Enrique Gómez-Gracia, Miquel Fiol, José Lapetra, Luis Serra-Majem, Xavier Pinto, Helmut Schröder, Josep Tur, José V Sorlí, Rosa M Lamuela-Raventós, Mónica Bulló, Maira Bes-Rastrollo, Miguel A Martinez-Gonzalez
The association of dietary energy density (ED) and overweight is not clear in the literature. Our aim was to study in 4259 of the PREDIMED trial whether an increase in dietary ED based on a higher adherence to a Mediterranean dietary pattern was associated with 3-year weight gain. A validated 137-item food-frequency questionnaire was administered. Multivariable-adjusted models were used to analyze the association between 3-year ED change and the subsequent 3-year body weight change. The most important weight reduction after 3-year follow-up was observed in the two lowest quintiles and the highest quintile of ED change...
March 6, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28273154/leisure-time-physical-activity-sedentary-behaviors-sleep-and-cardiometabolic-risk-factors-at-baseline-in-the-predimed-plus-intervention-trial-a-cross-sectional-analysis
#9
Nuria Rosique-Esteban, Andrés Díaz-López, Miguel A Martínez-González, Dolores Corella, Albert Goday, J Alfredo Martínez, Dora Romaguera, Jesus Vioque, Fernando Arós, Antonio Garcia-Rios, Francisco Tinahones, Ramon Estruch, José Carlos Fernández-García, José Lapetra, Luís Serra-Majem, Xavier Pinto, Josep A Tur, Aurora Bueno-Cavanillas, Josep Vidal, Miguel Delgado-Rodríguez, Lidia Daimiel, Clotilde Vázquez, Miguel Ángel Rubio, Emilio Ros, Jordi Salas-Salvadó
Limited data exists on the interrelationships between physical activity (PA), sedentary behaviors and sleep concerning cardiometabolic risk factors in aged adults at high cardiovascular disease risk. Our aim was to examine independent and joint associations between time spent in leisure-time PA, sedentary behaviors and sleep on the prevalence of obesity, type 2 diabetes (T2D) and components of the metabolic syndrome (MetS) in Mediterranean individuals at high cardiovascular risk. Cross-sectional analyses were performed on baseline data from 5776 Spanish adults (aged 55-75y in men; 60-75y in women) with overweight/obesity and MetS, from October 2013 to October 2016, in the PREDIMED-PLUS trial...
2017: PloS One
https://www.readbyqxmd.com/read/28218645/mediterranean-diet-and-phase-angle-in-a-sample-of-adult-population-results-of-a-pilot-study
#10
Luigi Barrea, Giovanna Muscogiuri, Paolo Emidio Macchia, Carolina Di Somma, Andrea Falco, Maria Cristina Savanelli, Annamaria Colao, Silvia Savastano
The Mediterranean diet is a healthy dietary pattern known to actively modulate the cell membrane properties. Phase angle (PhA) is a direct measure by Bioelectrical Impedance Analysis (BIA) used as marker of cell membrane integrity. Both food behaviour and PhA are influenced by age, sex and body weight. The aim of this study was to cross-sectionally evaluate the association between the adherence to Mediterranean diet and PhA in 1013 healthy adult patients stratified according to sex, age, and body mass index (BMI)...
February 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28202478/total-and-subtypes-of-dietary-fat-intake-and-risk-of-type-2-diabetes-mellitus-in-the-prevenci%C3%A3-n-con-dieta-mediterr%C3%A3-nea-predimed-study
#11
Marta Guasch-Ferré, Nerea Becerra-Tomás, Miguel Ruiz-Canela, Dolores Corella, Helmut Schröder, Ramon Estruch, Emilio Ros, Fernando Arós, Enrique Gómez-Gracia, Miquel Fiol, Lluís Serra-Majem, José Lapetra, Josep Basora, Nerea Martín-Calvo, Olga Portoles, Montserrat Fitó, Frank B Hu, Lluís Forga, Jordi Salas-Salvadó
Background: The associations between dietary fat and cardiovascular disease have been evaluated in several studies, but less is known about their influence on the risk of diabetes.Objective: We examined the associations between total fat, subtypes of dietary fat, and food sources rich in saturated fatty acids and the incidence of type 2 diabetes (T2D).Design: A prospective cohort analysis of 3349 individuals who were free of diabetes at baseline but were at high cardiovascular risk from the PREvención con DIeta MEDiterránea (PREDIMED) study was conducted...
February 15, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28193797/mediterranean-diet-improves-high-density-lipoprotein-function-in-high-cardiovascular-risk-individuals-a-randomized-controlled-trial
#12
Álvaro Hernáez, Olga Castañer, Roberto Elosua, Xavier Pintó, Ramón Estruch, Jordi Salas-Salvadó, Dolores Corella, Fernando Arós, Lluis Serra-Majem, Miquel Fiol, Manuel Ortega-Calvo, Emilio Ros, Miguel Ángel Martínez-González, Rafael de la Torre, M Carmen López-Sabater, Montserrat Fitó
BACKGROUND: The biological functions of high-density lipoproteins (HDLs) contribute to explaining the cardioprotective role of the lipoprotein beyond quantitative HDL cholesterol levels. A few small-scale interventions with a single antioxidant have improved some HDL functions. However, to date, no long-term, large-scale, randomized controlled trial has been conducted to assess the effects of an antioxidant-rich dietary pattern (such as a traditional Mediterranean diet [TMD]) on HDL function in humans...
February 14, 2017: Circulation
https://www.readbyqxmd.com/read/28185696/mediterranean-diet-adherence-by-patients-with-primary-open-angle-glaucoma
#13
J A Abreu-Reyes, D Álvarez-Luis, V Arteaga-Hernández, M Sánchez-Mendez, R Abreu-González
OBJECTIVE: To study the adherence to the Mediterranean diet in patients affected by primary open angle glaucoma (POAG). MATERIALS AND METHODS: An observational study was conducted to assess the adherence to the Mediterranean diet in patients affected by POAG, and who attended the Ophthalmology Department of the Canary Islands University Hospital. The study included completing a 14-item questionnaire validated by the PREDIMED Study, in person or by telephone. RESULTS: A total of 100 questionnaires were completed successfully by 50 males and 50 females...
February 6, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28181167/adherence-to-mediterranean-diet-is-associated-with-methylation-changes-in-inflammation-related-genes-in-peripheral-blood-cells
#14
A Arpón, J I Riezu-Boj, F I Milagro, C Razquin, M A Martínez-González, D Corella, R Estruch, R Casas, M Fitó, E Ros, J Salas-Salvadó, J A Martínez
Epigenetic processes, including DNA methylation, might be modulated by environmental factors such as the diet, which in turn have been associated with the onset of several diseases such as obesity or cardiovascular events. Meanwhile, Mediterranean diet (MedDiet) has demonstrated favourable effects on cardiovascular risk, blood pressure, inflammation and other complications related to excessive adiposity. Some of these effects could be mediated by epigenetic modifications. Therefore, the objective of this study was to investigate whether the adherence to MedDiet is associated with changes in the methylation status from peripheral blood cells...
February 8, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28179491/increases-in-plasma-tryptophan-are-inversely-associated-with-incident-cardiovascular-disease-in-the-prevenci%C3%A3-n-con-dieta-mediterr%C3%A3-nea-predimed-study
#15
Edward Yu, Miguel Ruiz-Canela, Marta Guasch-Ferré, Yan Zheng, Estefania Toledo, Clary B Clish, Jordi Salas-Salvadó, Liming Liang, Dong D Wang, Dolores Corella, Montse Fitó, Enrique Gómez-Gracia, José Lapetra, Ramón Estruch, Emilio Ros, Montserrat Cofán, Fernando Arós, Dora Romaguera, Lluis Serra-Majem, Jose V Sorlí, Frank B Hu, Miguel A Martinez-Gonzalez
Background: During development of cardiovascular disease (CVD), interferon-γ-mediated inflammation accelerates degradation of tryptophan into downstream metabolites. A Mediterranean diet (MedDiet) consisting of a high intake of extra-virgin olive oil (EVOO), nuts, fruits, vegetables, and cereals has been demonstrated to lower the risk of CVD. The longitudinal relation between tryptophan and its downstream metabolites and CVD in the context of a MedDiet is unstudied.Objective: We sought to investigate the relation between metabolites in the tryptophan-kynurenine pathway and CVD in the context of a MedDiet pattern...
March 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28143667/extra-virgin-olive-oil-consumption-reduces-the-risk-of-osteoporotic-fractures-in-the-predimed-trial
#16
J F García-Gavilán, M Bulló, S Canudas, M A Martínez-González, R Estruch, S Giardina, M Fitó, D Corella, E Ros, J Salas-Salvadó
BACKGROUND & AIMS: The incidence of osteoporotic fractures is lower in countries in the Mediterranean basin. Virgin olive oil, a key component of the Mediterranean Diet (MDiet), with recognised beneficial effects on metabolism and cardiovascular health, may decrease the risk of osteoporotic fractures. The aim to this study was to explore the effect of chronic consumption of total olive oil and its varieties on the risk of osteoporosis-related fractures in a middle-aged and elderly Mediterranean population...
January 13, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28133855/mediterranean-diet-and-risk-of-heart-failure-results-from-the-predimed-randomized-controlled-trial
#17
Angeliki Papadaki, Miguel Ángel Martínez-González, Angel Alonso-Gómez, Javier Rekondo, Jordi Salas-Salvadó, Dolores Corella, Emilio Ros, Montse Fitó, Ramon Estruch, José Lapetra, Antonio García-Rodriguez, Miquel Fiol, Lluís Serra-Majem, Xavier Pintó, Miguel Ruiz-Canela, Monica Bulló, Mercè Serra-Mir, Jose V Sorlí, Fernando Arós
AIMS: The aim of this study was to evaluate the effect of the Mediterranean diet (MedDiet) on the incidence of heart failure (HF), a pre-specified secondary outcome in the PREDIMED (PREvención con DIeta MEDiterránea) primary nutrition-intervention prevention trial. METHODS AND RESULTS: Participants at high risk of cardiovascular disease were randomly assigned to one of three diets: MedDiet supplemented with extra-virgin olive oil (EVOO), MedDiet supplemented with nuts, or a low-fat control diet...
January 30, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28126231/changes-in-fatty-liver-index-after-consuming-a-mediterranean-diet-6-year-follow-up-of-the-predimed-malaga-trial
#18
Raquel Cueto-Galán, Francisco Javier Barón, Pedro Valdivielso, Xavier Pintó, Emili Corbella, Enrique Gómez-Gracia, Julia Wärnberg
OBJECTIVE: To analyze the effect of an intervention with a Mediterranean diet supplemented with either extra virgin olive oil or nuts, on the fatty liver index (FLI), compared to a low-fat control diet. METHODS: Participants of the PREDIMED-Malaga trial, free from cardiovascular disease at baseline, but with a high risk to develop it, were included in this study. Anthropometric measurements were assessed and blood samples were taken to calculate participants' FLI at study baseline and after one, 3, 5 and 6 years...
January 23, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28078804/a-low-protein-diet-induces-body-weight-loss-and-browning-of-subcutaneous-white-adipose-tissue-through-enhanced-expression-of-hepatic-fibroblast-growth-factor-21-fgf21
#19
Albert Pérez-Martí, Maite Garcia-Guasch, Anna Tresserra-Rimbau, Alexandra Carrilho-Do-Rosário, Ramon Estruch, Jordi Salas-Salvadó, Miguel Ángel Martínez-González, Rosa Lamuela-Raventós, Pedro F Marrero, Diego Haro, Joana Relat
SCOPE: Fibroblast growth factor 21 (FGF21) is considered a promising therapeutic candidate for the treatment of obesity. Since FGF21 production is regulated by various nutritional factors, we analyze the impact of low protein intake on circulating levels of this growth hormone in mice and in a sub cohort of the PREDIMED (Prevención con Dieta Mediterránea) trial. We also describe the role of hepatic FGF21 in metabolic adaptation to a low-protein diet (LPD). METHODS AND RESULTS: We fed control and liver-specific Fgf21 knockout (LFgf21KO) mice a LPD...
January 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28075490/soluble-transferrin-receptor-and-risk-of-type-2-diabetes-in-the-obese-and-nonobese
#20
José C Fernández-Cao, Victoria Arija, Núria Aranda, Josep Basora, Javier Diez-Espino, Ramón Estruch, Montse Fitó, Dolores Corella, Jordi Salas-Salvadó
BACKGROUND: Studies evaluating the relationship between soluble transferrin receptor (sTfR), a biomarker inversely related to body iron stores, and risk of type 2 diabetes mellitus (T2DM) are scarce and inconclusive. Furthermore, sTfR concentrations have been observed to be significantly higher in obese than in nonobese individuals. Therefore, the aim of this study was to assess the relationship between sTfR and the risk of T2DM in obese and nonobese subjects. DESIGN: A nested case-control study of 153 cases of newly diagnosed diabetic subjects, 73 obese and 80 nonobese, and 306 individually matched controls, 138 obese and 166 nonobese, who did not develop T2DM for a median 6-year follow-up (interquartile range: 3·9-6·5) was conducted using data from the PREvention with MEDiterranean Diet (PREDIMED) cohort (http://www...
January 11, 2017: European Journal of Clinical Investigation
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