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https://www.readbyqxmd.com/read/28323949/plasma-arginine-asymmetric-dimethylarginine-ratio-and-incidence-of-cardiovascular-events-a-case-cohort-study
#1
Edward Yu, Miguel Ruiz-Canela, Frank B Hu, Clary B Clish, Dolores Corella, Jordi Salas-Salvadó, Adela Hruby, Montserrat Fitó, Liming Liang, Estefania Toledo, Emilio Ros, Ramón Estruch, Enrique Gómez-Gracia, Jose Lapetra, Fernando Arós, Dora Romaguera, Lluís Serra-Majem, Marta Guasch-Ferré, Dong D Wang, Miguel A Martínez-González
CONTEXT: Arginine, its methylated metabolites and other metabolites related to the urea cycle have been independently associated with cardiovascular risk, but the potential causal meaning of these associations (positive for some metabolites and negative for others) remains elusive due to a lack of studies measuring metabolite changes over time. OBJECTIVE: To examine the association between baseline and 1-year concentrations of urea cycle metabolites and cardiovascular disease in a case-cohort setting...
March 2, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28288977/prediction-of-cardiovascular-disease-by-the-framingham-regicor-equation-in-the-high-risk-predimed-cohort-impact-of-the-mediterranean-diet-across-different-risk-strata
#2
Antonio J Amor, Mercè Serra-Mir, Miguel A Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Montserrat Fitó, Ramón Estruch, Lluis Serra-Majem, Fernando Arós, Nancy Babio, Emilio Ros, Emilio Ortega
BACKGROUND: The usefulness of cardiovascular disease (CVD) predictive equations in different populations is debatable. We assessed the efficacy of the Framingham-REGICOR scale, validated for the Spanish population, to identify future CVD in participants, who were predefined as being at high-risk in the PREvención con DIeta MEDiterránea (PREDIMED) study-a nutrition-intervention primary prevention trial-and the impact of adherence to the Mediterranean diet on CVD across risk categories...
March 13, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28276290/dietary-energy-density-and-body-weight-changes-after-3-years-in-the-predimed-study
#3
Cristina Razquin, Ana Sanchez-Tainta, Jordi Salas-Salvadó, Pilar Buil-Cosiales, Dolores Corella, Montserrat Fito, Emilio Ros, Ramón Estruch, Fernando Arós, Enrique Gómez-Gracia, Miquel Fiol, José Lapetra, Luis Serra-Majem, Xavier Pinto, Helmut Schröder, Josep Tur, José V Sorlí, Rosa M Lamuela-Raventós, Mónica Bulló, Maira Bes-Rastrollo, Miguel A Martinez-Gonzalez
The association of dietary energy density (ED) and overweight is not clear in the literature. Our aim was to study in 4259 of the PREDIMED trial whether an increase in dietary ED based on a higher adherence to a Mediterranean dietary pattern was associated with 3-year weight gain. A validated 137-item food-frequency questionnaire was administered. Multivariable-adjusted models were used to analyze the association between 3-year ED change and the subsequent 3-year body weight change. The most important weight reduction after 3-year follow-up was observed in the two lowest quintiles and the highest quintile of ED change...
March 6, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28273154/leisure-time-physical-activity-sedentary-behaviors-sleep-and-cardiometabolic-risk-factors-at-baseline-in-the-predimed-plus-intervention-trial-a-cross-sectional-analysis
#4
Nuria Rosique-Esteban, Andrés Díaz-López, Miguel A Martínez-González, Dolores Corella, Albert Goday, J Alfredo Martínez, Dora Romaguera, Jesus Vioque, Fernando Arós, Antonio Garcia-Rios, Francisco Tinahones, Ramon Estruch, José Carlos Fernández-García, José Lapetra, Luís Serra-Majem, Xavier Pinto, Josep A Tur, Aurora Bueno-Cavanillas, Josep Vidal, Miguel Delgado-Rodríguez, Lidia Daimiel, Clotilde Vázquez, Miguel Ángel Rubio, Emilio Ros, Jordi Salas-Salvadó
Limited data exists on the interrelationships between physical activity (PA), sedentary behaviors and sleep concerning cardiometabolic risk factors in aged adults at high cardiovascular disease risk. Our aim was to examine independent and joint associations between time spent in leisure-time PA, sedentary behaviors and sleep on the prevalence of obesity, type 2 diabetes (T2D) and components of the metabolic syndrome (MetS) in Mediterranean individuals at high cardiovascular risk. Cross-sectional analyses were performed on baseline data from 5776 Spanish adults (aged 55-75y in men; 60-75y in women) with overweight/obesity and MetS, from October 2013 to October 2016, in the PREDIMED-PLUS trial...
2017: PloS One
https://www.readbyqxmd.com/read/28218645/mediterranean-diet-and-phase-angle-in-a-sample-of-adult-population-results-of-a-pilot-study
#5
Luigi Barrea, Giovanna Muscogiuri, Paolo Emidio Macchia, Carolina Di Somma, Andrea Falco, Maria Cristina Savanelli, Annamaria Colao, Silvia Savastano
The Mediterranean diet is a healthy dietary pattern known to actively modulate the cell membrane properties. Phase angle (PhA) is a direct measure by Bioelectrical Impedance Analysis (BIA) used as marker of cell membrane integrity. Both food behaviour and PhA are influenced by age, sex and body weight. The aim of this study was to cross-sectionally evaluate the association between the adherence to Mediterranean diet and PhA in 1013 healthy adult patients stratified according to sex, age, and body mass index (BMI)...
February 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28202478/total-and-subtypes-of-dietary-fat-intake-and-risk-of-type-2-diabetes-mellitus-in-the-prevenci%C3%A3-n-con-dieta-mediterr%C3%A3-nea-predimed-study
#6
Marta Guasch-Ferré, Nerea Becerra-Tomás, Miguel Ruiz-Canela, Dolores Corella, Helmut Schröder, Ramon Estruch, Emilio Ros, Fernando Arós, Enrique Gómez-Gracia, Miquel Fiol, Lluís Serra-Majem, José Lapetra, Josep Basora, Nerea Martín-Calvo, Olga Portoles, Montserrat Fitó, Frank B Hu, Lluís Forga, Jordi Salas-Salvadó
Background: The associations between dietary fat and cardiovascular disease have been evaluated in several studies, but less is known about their influence on the risk of diabetes.Objective: We examined the associations between total fat, subtypes of dietary fat, and food sources rich in saturated fatty acids and the incidence of type 2 diabetes (T2D).Design: A prospective cohort analysis of 3349 individuals who were free of diabetes at baseline but were at high cardiovascular risk from the PREvención con DIeta MEDiterránea (PREDIMED) study was conducted...
February 15, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28193797/mediterranean-diet-improves-high-density-lipoprotein-function-in-high-cardiovascular-risk-individuals-a-randomized-controlled-trial
#7
Álvaro Hernáez, Olga Castañer, Roberto Elosua, Xavier Pintó, Ramón Estruch, Jordi Salas-Salvadó, Dolores Corella, Fernando Arós, Lluis Serra-Majem, Miquel Fiol, Manuel Ortega-Calvo, Emilio Ros, Miguel Ángel Martínez-González, Rafael de la Torre, M Carmen López-Sabater, Montserrat Fitó
BACKGROUND: The biological functions of high-density lipoproteins (HDLs) contribute to explaining the cardioprotective role of the lipoprotein beyond quantitative HDL cholesterol levels. A few small-scale interventions with a single antioxidant have improved some HDL functions. However, to date, no long-term, large-scale, randomized controlled trial has been conducted to assess the effects of an antioxidant-rich dietary pattern (such as a traditional Mediterranean diet [TMD]) on HDL function in humans...
February 14, 2017: Circulation
https://www.readbyqxmd.com/read/28185696/mediterranean-diet-adherence-by-patients-with-primary-open-angle-glaucoma
#8
J A Abreu-Reyes, D Álvarez-Luis, V Arteaga-Hernández, M Sánchez-Mendez, R Abreu-González
OBJECTIVE: To study the adherence to the Mediterranean diet in patients affected by primary open angle glaucoma (POAG). MATERIALS AND METHODS: An observational study was conducted to assess the adherence to the Mediterranean diet in patients affected by POAG, and who attended the Ophthalmology Department of the Canary Islands University Hospital. The study included completing a 14-item questionnaire validated by the PREDIMED Study, in person or by telephone. RESULTS: A total of 100 questionnaires were completed successfully by 50 males and 50 females...
February 6, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28181167/adherence-to-mediterranean-diet-is-associated-with-methylation-changes-in-inflammation-related-genes-in-peripheral-blood-cells
#9
A Arpón, J I Riezu-Boj, F I Milagro, C Razquin, M A Martínez-González, D Corella, R Estruch, R Casas, M Fitó, E Ros, J Salas-Salvadó, J A Martínez
Epigenetic processes, including DNA methylation, might be modulated by environmental factors such as the diet, which in turn have been associated with the onset of several diseases such as obesity or cardiovascular events. Meanwhile, Mediterranean diet (MedDiet) has demonstrated favourable effects on cardiovascular risk, blood pressure, inflammation and other complications related to excessive adiposity. Some of these effects could be mediated by epigenetic modifications. Therefore, the objective of this study was to investigate whether the adherence to MedDiet is associated with changes in the methylation status from peripheral blood cells...
February 8, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28179491/increases-in-plasma-tryptophan-are-inversely-associated-with-incident-cardiovascular-disease-in-the-prevenci%C3%A3-n-con-dieta-mediterr%C3%A3-nea-predimed-study
#10
Edward Yu, Miguel Ruiz-Canela, Marta Guasch-Ferré, Yan Zheng, Estefania Toledo, Clary B Clish, Jordi Salas-Salvadó, Liming Liang, Dong D Wang, Dolores Corella, Montse Fitó, Enrique Gómez-Gracia, José Lapetra, Ramón Estruch, Emilio Ros, Montserrat Cofán, Fernando Arós, Dora Romaguera, Lluis Serra-Majem, Jose V Sorlí, Frank B Hu, Miguel A Martinez-Gonzalez
Background: During development of cardiovascular disease (CVD), interferon-γ-mediated inflammation accelerates degradation of tryptophan into downstream metabolites. A Mediterranean diet (MedDiet) consisting of a high intake of extra-virgin olive oil (EVOO), nuts, fruits, vegetables, and cereals has been demonstrated to lower the risk of CVD. The longitudinal relation between tryptophan and its downstream metabolites and CVD in the context of a MedDiet is unstudied.Objective: We sought to investigate the relation between metabolites in the tryptophan-kynurenine pathway and CVD in the context of a MedDiet pattern...
February 8, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28143667/extra-virgin-olive-oil-consumption-reduces-the-risk-of-osteoporotic-fractures-in-the-predimed-trial
#11
J F García-Gavilán, M Bulló, S Canudas, M A Martínez-González, R Estruch, S Giardina, M Fitó, D Corella, E Ros, J Salas-Salvadó
BACKGROUND & AIMS: The incidence of osteoporotic fractures is lower in countries in the Mediterranean basin. Virgin olive oil, a key component of the Mediterranean Diet (MDiet), with recognised beneficial effects on metabolism and cardiovascular health, may decrease the risk of osteoporotic fractures. The aim to this study was to explore the effect of chronic consumption of total olive oil and its varieties on the risk of osteoporosis-related fractures in a middle-aged and elderly Mediterranean population...
January 13, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28133855/mediterranean-diet-and-risk-of-heart-failure-results-from-the-predimed-randomized-controlled-trial
#12
Angeliki Papadaki, Miguel Ángel Martínez-González, Angel Alonso-Gómez, Javier Rekondo, Jordi Salas-Salvadó, Dolores Corella, Emilio Ros, Montse Fitó, Ramon Estruch, José Lapetra, Antonio García-Rodriguez, Miquel Fiol, Lluís Serra-Majem, Xavier Pintó, Miguel Ruiz-Canela, Monica Bulló, Mercè Serra-Mir, Jose V Sorlí, Fernando Arós
AIMS: The aim of this study was to evaluate the effect of the Mediterranean diet (MedDiet) on the incidence of heart failure (HF), a pre-specified secondary outcome in the PREDIMED (PREvención con DIeta MEDiterránea) primary nutrition-intervention prevention trial. METHODS AND RESULTS: Participants at high risk of cardiovascular disease were randomly assigned to one of three diets: MedDiet supplemented with extra-virgin olive oil (EVOO), MedDiet supplemented with nuts, or a low-fat control diet...
January 30, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28126231/changes-in-fatty-liver-index-after-consuming-a-mediterranean-diet-6-year-follow-up-of-the-predimed-malaga-trial
#13
Raquel Cueto-Galán, Francisco Javier Barón, Pedro Valdivielso, Xavier Pintó, Emili Corbella, Enrique Gómez-Gracia, Julia Wärnberg
OBJECTIVE: To analyze the effect of an intervention with a Mediterranean diet supplemented with either extra virgin olive oil or nuts, on the fatty liver index (FLI), compared to a low-fat control diet. METHODS: Participants of the PREDIMED-Malaga trial, free from cardiovascular disease at baseline, but with a high risk to develop it, were included in this study. Anthropometric measurements were assessed and blood samples were taken to calculate participants' FLI at study baseline and after one, 3, 5 and 6 years...
January 23, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28078804/a-low-protein-diet-induces-body-weight-loss-and-browning-of-subcutaneous-white-adipose-tissue-through-enhanced-expression-of-hepatic-fibroblast-growth-factor-21-fgf21
#14
Albert Pérez-Martí, Maite Garcia-Guasch, Anna Tresserra-Rimbau, Alexandra Carrilho-Do-Rosário, Ramon Estruch, Jordi Salas-Salvadó, Miguel Ángel Martínez-González, Rosa Lamuela-Raventós, Pedro F Marrero, Diego Haro, Joana Relat
SCOPE: Fibroblast growth factor 21 (FGF21) is considered a promising therapeutic candidate for the treatment of obesity. Since FGF21 production is regulated by various nutritional factors, we analyze the impact of low protein intake on circulating levels of this growth hormone in mice and in a sub cohort of the PREDIMED (Prevención con Dieta Mediterránea) trial. We also describe the role of hepatic FGF21 in metabolic adaptation to a low-protein diet (LPD). METHODS AND RESULTS: We fed control and liver-specific Fgf21 knockout (LFgf21KO) mice a LPD...
January 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28075490/soluble-transferrin-receptor-and-risk-of-type-2-diabetes-in-the-obese-and-nonobese
#15
José C Fernández-Cao, Victoria Arija, Núria Aranda, Josep Basora, Javier Diez-Espino, Ramón Estruch, Montse Fitó, Dolores Corella, Jordi Salas-Salvadó
BACKGROUND: Studies evaluating the relationship between soluble transferrin receptor (sTfR), a biomarker inversely related to body iron stores, and risk of type 2 diabetes mellitus (T2DM) are scarce and inconclusive. Furthermore, sTfR concentrations have been observed to be significantly higher in obese than in nonobese individuals. Therefore, the aim of this study was to assess the relationship between sTfR and the risk of T2DM in obese and nonobese subjects. DESIGN: A nested case-control study of 153 cases of newly diagnosed diabetic subjects, 73 obese and 80 nonobese, and 306 individually matched controls, 138 obese and 166 nonobese, who did not develop T2DM for a median 6-year follow-up (interquartile range: 3·9-6·5) was conducted using data from the PREvention with MEDiterranean Diet (PREDIMED) cohort (http://www...
January 11, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28067528/urinary-1-h-nmr-metabolomic-fingerprinting-reveals-biomarkers-of-pulse-consumption-related-to-energy-metabolism-modulation-in-a-subcohort-from-the-predimed-study
#16
Francisco Madrid-Gambin, Rafael Llorach, Rosa Vázquez-Fresno, Mireia Urpi-Sarda, Enrique Almanza-Aguilera, Mar Garcia-Aloy, Ramón Estruch, Dolores Corella, Cristina Andres-Lacueva
Little is known about the metabolome fingerprint of pulse consumption. The study of robust and accurate biomarkers for pulse dietary assessment has great value for nutritional epidemiology regarding health benefits and their mechanisms. To characterize the fingerprinting of dietary pulses (chickpeas, lentils and beans), spot urine samples from a subcohort from the PREDIMED study were stratified, using a validated food frequency questionnaire. Non-pulse consumers (≤ 4 g/day of pulse intake) and habitual pulse consumers (≥ 25 g/day of pulse intake) were analysed using a 1H-NMR metabolomics approach combined with multi- and univariate data analysis...
January 9, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28056794/mercury-exposure-and-risk-of-cardiovascular-disease-a-nested-case-control-study-in-the-predimed-prevention-with-mediterranean-diet-study
#17
Mary K Downer, Miguel A Martínez-González, Alfredo Gea, Meir Stampfer, Julia Warnberg, Miguel Ruiz-Canela, Jordi Salas-Salvadó, Dolores Corella, Emilio Ros, Montse Fitó, Ramon Estruch, Fernando Arós, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Monica Bullo, Jose V Sorli, Miguel A Muñoz, Antonio García-Rodriguez, Mario Gutierrez-Bedmar, Enrique Gómez-Gracia
BACKGROUND: Substantial evidence suggests that consuming 1-2 servings of fish per week, particularly oily fish (e.g., salmon, herring, sardines) is beneficial for cardiovascular health due to its high n-3 polyunsaturated fatty acid content. However, there is some concern that the mercury content in fish may increase cardiovascular disease risk, but this relationship remains unclear. METHODS: The PREDIMED trial included 7477 participants who were at high risk for cardiovascular disease at baseline...
January 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28041856/associations-between-both-lignan-and-yogurt%C3%A2-consumption-and-cardiovascular-risk%C3%A2-parameters-in-an-elderly-population-observations-from-a-cross-sectional-approach%C3%A2-in-the-predimed-study
#18
Anna Creus-Cuadros, Anna Tresserra-Rimbau, Paola Quifer-Rada, Miguel Angel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Montse Fitó, Ramon Estruch, Enrique Gómez-Gracia, José Lapetra, Fernando Arós, Miquel Fiol, Emili Ros, Lluís Serra-Majem, Xavier Pintó, Juan José Moreno, Miguel Ruiz-Canela, Jose Vicente Sorli, Josep Basora, Helmut Schröder, Rosa Maria Lamuela-Raventós
BACKGROUND: The study of dietary patterns is gaining interest. Although the health benefits of yogurt and lignans have been investigated separately, to our knowledge there are no studies on their associative effects. OBJECTIVE: The aim of this study was to evaluate a possible association between yogurt and lignans using biomarkers of cardiovascular disease risk in an elderly population. DESIGN: We conducted a cross-sectional analysis of the association between baseline dietary information and cardiovascular risk parameters using food frequency questionnaires...
December 29, 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27929407/polymorphism-of-the-transcription-factor-7-like-2-gene-tcf7l2-interacts-with-obesity-on-type-2-diabetes-in-the-predimed-study-emphasizing-the-heterogeneity-of-genetic-variants-in-type-2-diabetes-risk-prediction-time-for-obesity-specific-genetic-risk-scores
#19
Dolores Corella, Oscar Coltell, Jose V Sorlí, Ramón Estruch, Laura Quiles, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Olga Castañer, Fernando Arós, Manuel Ortega-Calvo, Lluís Serra-Majem, Enrique Gómez-Gracia, Olga Portolés, Miquel Fiol, Javier Díez Espino, Josep Basora, Montserrat Fitó, Emilio Ros, José M Ordovás
Nutrigenetic studies analyzing gene-diet interactions of the TCF7L2-rs7903146 C > T polymorphism on type-2 diabetes (T2D) have shown controversial results. A reason contributing to this may be the additional modulation by obesity. Moreover, TCF7L2-rs7903146 is one of the most influential variants in T2D-genetic risk scores (GRS). Therefore, to increase the predictive value (PV) of GRS it is necessary to first see whether the included polymorphisms have heterogeneous effects. We comprehensively investigated gene-obesity interactions between the TCF7L2-rs7903146 C > T polymorphism on T2D (prevalence and incidence) and analyzed other T2D-polymorphisms in a sub-sample...
December 6, 2016: Nutrients
https://www.readbyqxmd.com/read/27923356/metric-properties-of-the-prescribe-healthy-life-screening-questionnaire-to-detect-healthy-behaviors-a-cross-sectional-pilot-study
#20
Paola Bully, Alvaro Sanchez, Gonzalo Grandes, Haizea Pombo, Ma Soledad Arietalenizbeaskoa, Veronica Arce, Catalina Martinez
BACKGROUND: Feasible and valid assessment of healthy behaviors is the first step for integrating health promotion in routine primary care. Therefore, the aim of this study was to develop and evaluate the validity and reliability of the "prescribe healthy life" screening questionnaire, a brief tool for detecting physical activity levels, consumption of fruit and vegetables, tobacco use and patients' compliance with minimal recommendations. METHODS: An observational cross-sectional study to determine the reliability and validity of this questionnaire by means of mixed (qualitative and quantitative) methods...
December 7, 2016: BMC Public Health
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