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https://www.readbyqxmd.com/read/29663011/plasma-branched-chain-aromatic-amino-acids-enriched-mediterranean-diet-and-risk-of-type-2-diabetes-case-cohort-study-within-the-predimed-trial
#1
Miguel Ruiz-Canela, Marta Guasch-Ferré, Estefanía Toledo, Clary B Clish, Cristina Razquin, Liming Liang, Dong D Wang, Dolores Corella, Ramón Estruch, Álvaro Hernáez, Edward Yu, Enrique Gómez-Gracia, Yan Zheng, Fernando Arós, Dora Romaguera, Courtney Dennis, Emilio Ros, José Lapetra, Lluis Serra-Majem, Christopher Papandreou, Olga Portoles, Montserrat Fitó, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González
AIMS/HYPOTHESIS: Branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and their interactions with dietary interventions have not been evaluated. We investigated the associations between baseline and changes at 1 year in BCAA/AAA with type 2 diabetes in the context of a Mediterranean diet (MedDiet) trial. METHODS: We included 251 participants with incident type 2 diabetes and a random sample of 694 participants (641 participants without type 2 diabetes and 53 overlapping cases) in a case-cohort study nested within the PREvención con DIeta MEDiterránea (PREDIMED) trial...
April 16, 2018: Diabetologia
https://www.readbyqxmd.com/read/29643004/association-between-mediterranean-diet-and-hand-grip-strength-in-older-adult-women
#2
Luigi Barrea, Giovanna Muscogiuri, Carolina Di Somma, Giovanni Tramontano, Vincenzo De Luca, Maddalena Illario, Annamaria Colao, Silvia Savastano
BACKGROUND & AIMS: Mediterranean Diet (MD) is an eating pattern associated with multiple healthy benefits, including the conservation of skeletal muscle. Frailty is a major geriatric syndrome characterized by low muscle strength. The Hand Grip Strength (HGS) is the most frequently used indicator of muscle functional capacity for clinical purposes. The association between the adherence to the MD and HGS in elderly has not yet fully investigated. The goal of this study was to examine the association between the adherence to the MD and HGS in a not hospitalized elderly who participated in the project PERsonalised ict Supported Services for Independent Living and Active Ageing (PERSSILAA)...
April 3, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29589119/dairy-products-intake-and-the-risk-of-incident-cataracts-surgery-in-an-elderly-mediterranean-population-results-from-the-predimed-study
#3
Lucía Camacho-Barcia, Mònica Bulló, Jesús F García-Gavilán, Miguel A Martínez-González, Dolores Corella, Ramón Estruch, Montse Fitó, Enrique Gómez-Gracia, Fernando Arós, Miquel Fiol, José M Santos-Lozano, Lluís Serra-Majem, Xavier Pintó, Josep Basora, Estefanía Toledo, Miguel A Muñoz, Vicente Zanon-Moreno, Alfredo García-Layana, Jordi Salas-Salvadó
PROPOSAL: The aim of this study was to examine the association between the consumption of total and specific types of dairy products and the risk of incident cataracts in an elderly Mediterranean population at high cardiovascular risk. METHODS: We prospectively analyzed 5860 subjects from the PREvención con DIeta MEDiterránea (PREDIMED) Study. The time to cataract surgery was calculated as the time between recruitment and the date of the surgery, last visit of the follow-up, date of death, or until the end of the study...
March 27, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29566197/effect-of-the-mediterranean-diet-on-cognition-and-brain-morphology-and-function-a-systematic-review-of-randomized-controlled-trials
#4
Sue Radd-Vagenas, Shantel L Duffy, Sharon L Naismith, Bruce J Brew, Victoria M Flood, Maria A Fiatarone Singh
Background: Observational studies of the Mediterranean diet suggest cognitive benefits, potentially reducing dementia risk. Objective: We performed the first published review to our knowledge of randomized controlled trials (RCTs) investigating Mediterranean diet effects on cognition or brain morphology and function, with an additional focus on intervention diet quality and its relation to "traditional" Mediterranean dietary patterns. Design: We searched 9 databases from inception (final update December 2017) for RCTs testing a Mediterranean compared with alternate diet for cognitive or brain morphology and function outcomes...
March 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29555466/non-targeted-metabolomic-biomarkers-and-metabotypes-of-type-2-diabetes-a-cross-sectional-study-of-predimed-trial-participants
#5
M Urpi-Sarda, E Almanza-Aguilera, R Llorach, R Vázquez-Fresno, R Estruch, D Corella, J V Sorli, F Carmona, A Sanchez-Pla, J Salas-Salvadó, C Andres-Lacueva
AIM: To characterize the urinary metabolomic fingerprint and multi-metabolite signature associated with type 2 diabetes (T2D), and to classify the population into metabotypes related to T2D. METHODS: A metabolomics analysis using the1 H-NMR-based, non-targeted metabolomic approach was conducted to determine the urinary metabolomic fingerprint of T2D compared with non-T2D participants in the PREDIMED trial. The discriminant metabolite fingerprint was subjected to logistic regression analysis and ROC analyses to establish and to assess the multi-metabolite signature of T2D prevalence, respectively...
February 20, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29554269/association-of-physical-activity-with-body-mass-index-waist-circumference-and-incidence-of-obesity-in-older-adults
#6
Gabriela Cárdenas Fuentes, Rowaedh Ahmed Bawaked, Miguel Ángel Martínez González, Dolores Corella, Isaac Subirana Cachinero, Jordi Salas-Salvadó, Ramón Estruch, Lluis Serra-Majem, Emilio Ros, José Lapetra Peralta, Miguel Fiol, Javier Rekondo, Enrique Gómez-Gracia, Josep Antoni Tur Marí, Xavier Pinto Sala, Nancy Babio, Carolina Ortega, José Alfredo Martínez, Helmut Schröder
Background: There is limited, and inconsistent, data on the prospective association between physical activity and surrogate markers of adiposity in older adults. We aim to determine the prospective association of leisure time physical activity (LTPA) with body mass index (BMI), waist circumference (WC) and the incidence of obesity. Methods: This prospective analysis included 7144 individuals with a mean age of 67 ± 6.2 years, from the PREvención con DIeta MEDiterránea (PREDIMED) study...
March 15, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29549354/the-antioxidant-potential-of-the-mediterranean-diet-in-patients-at-high-cardiovascular-risk-an-in-depth-review-of-the-predimed
#7
Hayley E Billingsley, Salvatore Carbone
Cardiovascular disease (CVD) is the leading global cause of death. Diet is known to be important in the prevention of CVD. The PREDIMED trial tested a relatively low-fat diet versus a high-fat Mediterranean diet (MedDiet) for the primary prevention of CVD. The resulting reduction of the CV composite outcome resulted in a paradigm shift in CV nutrition. Though many dietary factors likely contributed to this effect, this review focuses on the influence of the MedDiet on endogenous antioxidant systems and the effect of dietary polyphenols...
March 9, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29484470/prediction-of-clamp-derived-insulin-sensitivity-from-the-oral-glucose-insulin-sensitivity-index
#8
Andrea Tura, Gaetano Chemello, Julia Szendroedi, Christian Göbl, Kristine Færch, Jana Vrbíková, Giovanni Pacini, Ele Ferrannini, Michael Roden
AIMS/HYPOTHESIS: The euglycaemic-hyperinsulinaemic clamp is the gold-standard method for measuring insulin sensitivity, but is less suitable for large clinical trials. Thus, several indices have been developed for evaluating insulin sensitivity from the oral glucose tolerance test (OGTT). However, most of them yield values different from those obtained by the clamp method. The aim of this study was to develop a new index to predict clamp-derived insulin sensitivity (M value) from the OGTT-derived oral glucose insulin sensitivity index (OGIS)...
February 26, 2018: Diabetologia
https://www.readbyqxmd.com/read/29382082/validation-of-the-english-version-of-the-14-item-mediterranean-diet-adherence-screener-of-the-predimed-study-in-people-at-high-cardiovascular-risk-in-the-uk
#9
Angeliki Papadaki, Laura Johnson, Zoi Toumpakari, Clare England, Manmita Rai, Stu Toms, Chris Penfold, Itziar Zazpe, Miguel A Martínez-González, Gene Feder
The aim of this study was to examine the validity of the English version of the PREvencion con DIetaMEDiterranea (PREDIMED) 14-item Mediterranean Diet Adherence Screener (MEDAS), a brief questionnaire assessing adherence to the Mediterranean diet (MedDiet), which was used in the PREDIMED trial for assessment and immediate feedback. This instrument (MEDAS) was administered to 96 adults with a high cardiovascular risk (66% women, mean age 68.3 ± 6.0 years), recruited from general practices in Bristol, UK. Participants then completed a 3-day estimated food record, and the MEDAS was administered again one month later...
January 28, 2018: Nutrients
https://www.readbyqxmd.com/read/29366273/the-predimed-score-index-of-adherence-to-the-mediterranean-diet-in-the-general-population-the-plic-study
#10
Clara Visinoni, Laura Redaelli, Cristina Tidone, Katia Garlaschelli, Liliana Grigore, Andrea Baragetti, Giuseppe Danilo Norata, Alberico Luigi Catapano
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29352655/legume-consumption-and-risk-of-all-cause-cardiovascular-and-cancer-mortality-in-the-predimed-study
#11
Christopher Papandreou, Nerea Becerra-Tomás, Mònica Bulló, Miguel Ángel Martínez-González, Dolores Corella, Ramon Estruch, Emilio Ros, Fernando Arós, Helmut Schroder, Montserrat Fitó, Lluís Serra-Majem, José Lapetra, Miquel Fiol, Miguel Ruiz-Canela, Jose V Sorli, Jordi Salas-Salvadó
BACKGROUND & AIMS: Limited prospective studies have examined the association between legumes consumption and mortality, whereas scarce, if at all, previous studies have evaluated such associations taking into consideration specific grain legumes. We aimed to investigate the association between total legumes consumption and grain legumes species (dry beans, chickpeas, lentils, and fresh peas) with all-cause, cardiovascular disease (CVD), cancer and other-cause mortality among elderly Mediterranean individuals at high CVD risk...
January 9, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29316612/association-between-diet-quality-scores-adiposity-total-cholesterol-and-markers-of-nutritional-status-in-european-adults-findings-from-the-food4me-study
#12
Rosalind Fallaize, Katherine M Livingstone, Carlos Celis-Morales, Anna L Macready, Rodrigo San-Cristobal, Santiago Navas-Carretero, Cyril F M Marsaux, Clare B O'Donovan, Silvia Kolossa, George Moschonis, Marianne C Walsh, Eileen R Gibney, Lorraine Brennan, Jildau Bouwman, Yannis Manios, Miroslaw Jarosz, J Alfredo Martinez, Hannelore Daniel, Wim H M Saris, Thomas E Gundersen, Christian A Drevon, Michael J Gibney, John C Mathers, Julie A Lovegrove
Diet-quality scores (DQS), which are developed across the globe, are used to define adherence to specific eating patterns and have been associated with risk of coronary heart disease and type-II diabetes. We explored the association between five diet-quality scores (Healthy Eating Index, HEI; Alternate Healthy Eating Index, AHEI; MedDietScore, MDS; PREDIMED Mediterranean Diet Score, P-MDS; Dutch Healthy Diet-Index, DHDI) and markers of metabolic health (anthropometry, objective physical activity levels (PAL), and dried blood spot total cholesterol (TC), total carotenoids, and omega-3 index) in the Food4Me cohort, using regression analysis...
January 6, 2018: Nutrients
https://www.readbyqxmd.com/read/29306452/plasma-lipidome-patterns-associated-with-cardiovascular-risk-in-the-predimed-trial-a-case-cohort-study
#13
Cristina Razquin, Liming Liang, Estefanía Toledo, Clary B Clish, Miguel Ruiz-Canela, Yan Zheng, Dong D Wang, Dolores Corella, Olga Castaner, Emilio Ros, Fernando Aros, Enrique Gomez-Gracia, Miquel Fiol, José Manuel Santos-Lozano, Marta Guasch-Ferre, Lluis Serra-Majem, Aleix Sala-Vila, Pilar Buil-Cosiales, Monica Bullo, Montserrat Fito, Olga Portoles, Ramon Estruch, Jordi Salas-Salvado, Frank B Hu, Miguel A Martinez-Gonzalez
BACKGROUND: The study of the plasma lipidome may help to better characterize molecular mechanisms underlying cardiovascular disease. The identification of new lipid biomarkers could provide future targets for prevention and innovative therapeutic approaches. In the frame of the PREDIMED trial, our aim was to examine the associations of baseline lipidome patterns or their changes with the risk of clinical CVD events. METHODS: We included 983 participants in our case-cohort study...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29305130/effects-of-the-ser326cys-polymorphism-in-the-dna-repair-ogg1-gene-on-cancer-cardiovascular-and-all-cause-mortality-in-the-predimed-study-modulation-by-diet
#14
Dolores Corella, Judith B Ramírez-Sabio, Oscar Coltell, Carolina Ortega-Azorín, Ramón Estruch, Miguel A Martínez-González, Jordi Salas-Salvadó, José V Sorlí, Olga Castañer, Fernando Arós, Franscisco J Garcia-Corte, Lluís Serra-Majem, Enrique Gómez-Gracia, Miquel Fiol, Xavier Pintó, Guillermo T Saez, Estefanía Toledo, Josep Basora, Montserrat Fitó, Montserrat Cofán, Emilio Ros, Jose M Ordovas
BACKGROUND: Oxidatively induced DNA damage, an important factor in cancer etiology, is repaired by oxyguanine glycosylase 1 (OGG1). The lower repair capacity genotype (homozygote Cys326Cys) in the OGG1-rs1052133 (Ser326Cys) polymorphism has been associated with cancer risk. However, no information is available in relation to cancer mortality, other causes of death, and modulation by diet. OBJECTIVE: Our aim was to evaluate the association of the OGG1-rs1052133 with total, cancer, and cardiovascular disease (CVD) mortality and to analyze its modulation by the Mediterranean diet, focusing especially on total vegetable intake as one of the main characteristics of this diet...
April 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29295516/impact-of-consuming-extra-virgin-olive-oil-or-nuts-within-a-mediterranean-diet-on-dna-methylation-in-peripheral-white-blood-cells-within-the-predimed-navarra-randomized-controlled-trial-a-role-for-dietary-lipids
#15
Ana Arpón, Fermín I Milagro, Cristina Razquin, Dolores Corella, Ramón Estruch, Montserrat Fitó, Amelia Marti, Miguel A Martínez-González, Emilio Ros, Jordi Salas-Salvadó, José-Ignacio Riezu-Boj, J Alfredo Martínez
DNA methylation could be reversible and mouldable by environmental factors, such as dietary exposures. The objective was to analyse whether an intervention with two Mediterranean diets, one rich in extra-virgin olive oil (MedDiet + EVOO) and the other one in nuts (MedDiet + nuts), was influencing the methylation status of peripheral white blood cells (PWBCs) genes. A subset of 36 representative individuals were selected within the PREvención con DIeta MEDiterránea (PREDIMED-Navarra) trial, with three intervention groups in high cardiovascular risk volunteers: MedDiet + EVOO, MedDiet + nuts, and a low-fat control group...
December 23, 2017: Nutrients
https://www.readbyqxmd.com/read/29236075/risks-and-benefits-of-increased-nut-consumption-cardiovascular-health-benefits-outweigh-the-burden-of-carcinogenic-effects-attributed-to-aflatoxin-b%C3%A2-exposure
#16
Hanna Eneroth, Stina Wallin, Karin Leander, Johan Nilsson Sommar, Agneta Åkesson
Nuts are rich in nutrients and mounting evidence shows that consumption reduces cardiovascular disease (CVD) incidence. Nuts may also be a major source of aflatoxin B₁, a potent liver carcinogen and the risk/benefit balance is unknown. Based on national statistics and data from the PREDIMED intervention trial, we estimated the potential CVD-reduction if Swedes aged 55-79 consumed 30 g nuts/day, instead of the current national average of five grams per day. We also assessed the reduction in disability-adjusted life years (DALYs) due to myocardial infarction (MI) and stroke...
December 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29099027/the-effects-of-dietary-nutrition-education-on-weight-and-health-biomarkers-in-breast-cancer-survivors
#17
Andrea Braakhuis, Peta Campion, Karen Bishop
Weight gain after breast cancer diagnosis portends a poorer prognosis, and the majority of sufferers appear to gain weight. Metabolic syndrome is a common co-condition with breast cancer. The Mediterranean diet has been used to reduce excess weight, metabolic syndrome, and to improve the inflammatory profile, and therefore may offer the breast cancer survivor specific benefits over and above the currently recommended nutrition guidelines to eat a low fat, healthy diet. The aim of this randomised controlled trial was to investigate whether a Mediterranean (MD) or low-fat diet (LF) reduce weight and general health in survivors of stage 1-3 breast cancer through a six-month, six-session education package to support dietary change...
June 2, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29080862/plasma-metabolites-from-choline-pathway-and-risk-of-cardiovascular-disease-in-the-predimed-prevention-with-mediterranean-diet-study
#18
Marta Guasch-Ferré, Frank B Hu, Miguel Ruiz-Canela, Mònica Bulló, Estefanía Toledo, Dong D Wang, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, Ramon Estruch, José Lapetra, Montserrat Fitó, Fernando Arós, Lluís Serra-Majem, Emilio Ros, Courtney Dennis, Liming Liang, Clary B Clish, Miguel A Martínez-González, Jordi Salas-Salvadó
BACKGROUND: The relationship between plasma concentrations of betaine and choline metabolism and major cardiovascular disease (CVD) end points remains unclear. We have evaluated the association between metabolites from the choline pathway and risk of incident CVD and the potential modifying effect of Mediterranean diet interventions. METHODS AND RESULTS: We designed a case-cohort study nested within the PREDIMED (Prevention With Mediterranean Diet) trial, including 229 incident CVD cases and 751 randomly selected participants at baseline, followed up for 4...
October 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29046405/potato-consumption-does-not-increase-blood-pressure-or-incident-hypertension-in-2-cohorts-of-spanish-adults
#19
Emily A Hu, Miguel A Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Emilio Ros, Montse Fitó, Antonio Garcia-Rodriguez, Ramon Estruch, Fernando Arós, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Xavier Pintó, Miguel Ruiz-Canela, Cristina Razquin, Mònica Bulló, José V Sorlí, Helmut Schröder, Casey M Rebholz, Estefania Toledo
Background: Potatoes have a high glycemic load but also antioxidants, vitamins, and minerals. It is unclear what mechanisms are involved in relation to their effect on blood pressure (BP) and hypertension. Objectives: This study aimed to assess the association between potato consumption, BP changes, and the risk of hypertension in 2 Spanish populations. Methods: Separate analyses were performed in PREDIMED (PREvención con DIeta MEDiterránea), a multicenter nutrition intervention trial of adults aged 55-80 y, and the SUN (Seguimiento Universidad de Navarra) project, a prospective cohort made up of university graduates and educated adults with ages (means ± SDs) of 42...
December 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/29035971/dietary-patterns-and-cognition-in-older-persons
#20
Angela M Abbatecola, Marcello Russo, Michelangela Barbieri
PURPOSE OF REVIEW: The current article reviews recently published evidence of the important role that specific dietary patterns may hold on preventing cognitive impairment and dementia over aging. RECENT FINDINGS: Specific dietary patterns attributed to targeting cardiovascular risk factors may protect against the development of mild cognitive impairment (MCI) and dementia, especially Alzheimer's disease. Numerous epidemiological studies have strongly suggested that multinutrient approaches using the Mediterranean diet (Med diet), dietary approach to systolic hypertension (DASH) and the Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) are associated with a lower risk of cognitive impairment, MCI and Alzheimer's disease in older persons...
January 2018: Current Opinion in Clinical Nutrition and Metabolic Care
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