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Miguel A Martínez-González
Abundant and growing evidence has accrued to demonstrate that the traditional Mediterranean diet is likely to be the ideal dietary pattern for the prevention of cardiovascular disease. A landmark randomized trial (PREDIMED) together with many well-conducted long-term observational prospective cohort studies support this causal effect.A new, large British cohort study by Tong et al. assessing the association between adherence to the Mediterranean diet and cardiovascular disease was recently published in BMC Medicine...
October 14, 2016: BMC Medicine
Sébastien Lacroix, Jennifer Cantin, Anil Nigam
In this article, we discuss certain contemporary and controversial topics in cardiovascular (CV) nutrition including recent data regarding the health benefits of the Mediterranean diet, the role of saturated fatty acids, red meat and the microbiome in CV disease and the current role of personalized CV nutrition. Findings from the PREDIMED study now demonstrate the health benefits of the Mediterranean diet even in the absence of heart disease. The study highlighted that even small, sustained and easily implementable changes to diet can provide significant health benefits even in Mediterranean regions...
September 15, 2016: Annals of Physical and Rehabilitation Medicine
Yan Zheng, Frank B Hu, Miguel Ruiz-Canela, Clary B Clish, Courtney Dennis, Jordi Salas-Salvado, Adela Hruby, Liming Liang, Estefania Toledo, Dolores Corella, Emilio Ros, Montserrat Fitó, Enrique Gómez-Gracia, Fernando Arós, Miquel Fiol, José Lapetra, Lluis Serra-Majem, Ramón Estruch, Miguel A Martínez-González
BACKGROUND: Glutamate metabolism may play a role in the pathophysiology of cardiometabolic disorders. However, there is limited evidence of an association between glutamate-related metabolites and, moreover, changes in these metabolites, and risk of cardiovascular disease (CVD). METHODS AND RESULTS: Plasma levels of glutamate and glutamine were measured at baseline and 1-year follow-up in a case-cohort study including 980 participants (mean age 68 years; 46% male) from the PREvención con DIeta MEDiterránea (PREDIMED) randomized trial, which assessed a Mediterranean diet intervention in the primary prevention of CVD...
September 2016: Journal of the American Heart Association
Caren E Smith, Oscar Coltell, Jose V Sorlí, Ramón Estruch, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Montserrat Fitó, Fernando Arós, Hassan S Dashti, Chao Q Lai, Leticia Miró, Lluís Serra-Majem, Enrique Gómez-Gracia, Miquel Fiol, Emilio Ros, Stella Aslibekyan, Bertha Hidalgo, Marian L Neuhouser, Chongzhi Di, Katherine L Tucker, Donna K Arnett, José M Ordovás, Dolores Corella
Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through Mendelian randomization. We meta-analytically (n ≤ 20,089) evaluated associations between a lactase persistence (LP) SNP, the minichromosome maintenance complex component 6 (MCM6)-rs3754686C>T (nonpersistence>persistence), dairy intake, and CVD biomarkers in American (Hispanics, African-American and Whites) and Mediterranean populations...
2016: Scientific Reports
Antoni Sureda, Maria Del Mar Bibiloni, Miquel Martorell, Pilar Buil-Cosiales, Amelia Marti, Antoni Pons, Josep A Tur, Miguel Ángel Martinez-Gonzalez
SCOPE: This study assessed plasmatic antioxidant capabilities and xanthine oxidase activity in metabolic syndrome (MetS) patients after 5 years intervention with Mediterranean Diet (MeDiet) supplemented with extra-virgin olive oil (MeDiet+EVOO) or with nuts or with low-fat diet (the PREDIMED study). METHODS AND RESULTS: 75 participants were randomly selected. Daily energy and nutrient intake were assessed with a validated 137-item food frequency questionnaire, and adherence to the MeDiet was assessed using a 14-item questionnaire...
September 7, 2016: Molecular Nutrition & Food Research
Aleix Sala-Vila, Andrés Díaz-López, Cinta Valls-Pedret, Montserrat Cofán, Alfredo García-Layana, Rosa-María Lamuela-Raventós, Olga Castañer, Vicente Zanon-Moreno, Miguel A Martinez-Gonzalez, Estefanía Toledo, Josep Basora, Jordi Salas-Salvadó, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, Ramón Estruch, José Lapetra, Montserrat Fitó, Fernando Arós, Luis Serra-Majem, Xavier Pintó, Emilio Ros
Importance: Diabetic retinopathy (DR) is a devastating complication of individuals with type 2 diabetes mellitus. The retina is rich in long-chain ω-3 polyunsaturated fatty acids (LCω3PUFAs), which are substrate for oxylipins with anti-inflammatory and antiangiogenic properties. Experimental models support dietary LCω3PUFA protection against DR, but clinical data are lacking. Objective: To determine whether LCω3PUFA intake relates to a decreased incidence of sight-threatening DR in individuals with type 2 diabetes older than 55 years...
October 1, 2016: JAMA Ophthalmology
Rocío Barragán, Oscar Coltell, Eva M Asensio, Francesc Francés, José V Sorlí, Ramon Estruch, Albert Salas-Huetos, Jose M Ordovas, Dolores Corella
Recently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has focused on analyzing polymorphisms in genes encoding miRNAs and daily alcohol consumption at the population level. Our aim was to investigate the association between a functional polymorphism in the pre-miR-27a (rs895819 A>G) gene and alcohol consumption in an elderly population. We undertook a cross-sectional study of PREvención con DIeta MEDiterránea (PREDIMED)-Valencia participants (n = 1007, including men and women aged 67 ± 7 years) and measured their alcohol consumption (total and alcoholic beverages) through a validated questionnaire...
2016: International Journal of Molecular Sciences
J Díez-Espino, F J Basterra-Gortari, J Salas-Salvadó, P Buil-Cosiales, D Corella, H Schröder, R Estruch, E Ros, E Gómez-Gracia, F Arós, M Fiol, J Lapetra, L Serra-Majem, X Pintó, N Babio, L Quiles, M Fito, A Marti, E Toledo
BACKGROUND: Eggs are a major source of dietary cholesterol and their consumption has been sometimes discouraged. A relationship between egg consumption and the incidence of cardiovascular disease (CVD) has been suggested to be present exclusively among patients with type2 diabetes. AIMS: To assess the association between egg consumption and CVD in a large Mediterranean cohort where approximately 50% of participants had type 2 diabetes. METHODS: We prospectively followed 7216 participants (55-80 years old) at high cardiovascular risk from the PREDIMED (PREvención con DIeta MEDiterránea) study for a mean of 5...
June 29, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Cíntia Ferreira-Pêgo, Nancy Babio, Maira Bes-Rastrollo, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó, Lluís Serra-Majem, Fernando Arós, Miguel Fiol, José Manuel Santos-Lozano, Carlos Muñoz-Bravo, Xavier Pintó, Miguel Ruiz-Canela, Jordi Salas-Salvadó
BACKGROUND: The relation between the consumption of sweetened beverages and metabolic syndrome (MetS) is controversial. OBJECTIVE: This analysis evaluated the associations between intakes of sugar-sweetened beverages (SSBs), artificially sweetened beverages, and natural and bottled fruit juices and the incidence of MetS in elderly individuals at high risk of cardiovascular disease (CVD) and without MetS at baseline. METHODS: We prospectively examined 1868 participants free of MetS at baseline from the PREDIMED (PREvención con DIeta MEDiterránea) study...
August 2016: Journal of Nutrition
Jacqueline Álvarez-Pérez, Almudena Sánchez-Villegas, Elena María Díaz-Benítez, Cristina Ruano-Rodríguez, Dolores Corella, Míguel Ángel Martínez-González, Ramón Estruch, Jordi Salas-Salvadó, Lluís Serra-Majem
OBJECTIVE: To assess the influence of a Mediterranean dietary pattern (MeDiet) on anthropometric and body composition parameters in one of the centers of the PREDIMED randomized dietary trial. SUBJECTS/SETTINGS: 351 Canarian free-living subjects aged 55 to 80 years, with type 2 diabetes or ≥3 cardiovascular risk factors. INTERVENTION: Participants were randomly assigned to one of 3 different dietary interventions: MeDiet + extra-virgin olive oil (EVOO), MeDiet + nuts (walnuts, almonds, and hazelnuts), or a control low-fat diet...
June 17, 2016: Journal of the American College of Nutrition
Mary Kathryn Downer, Alfredo Gea, Meir Stampfer, Ana Sánchez-Tainta, Dolores Corella, Jordi Salas-Salvadó, Emilio Ros, Ramón Estruch, Montserrat Fitó, Enrique Gómez-Gracia, Fernando Arós, Miquel Fiol, Francisco Jose Garcia De-la-Corte, Lluís Serra-Majem, Xavier Pinto, Josep Basora, José V Sorlí, Ernest Vinyoles, Itziar Zazpe, Miguel-Ángel Martínez-González
BACKGROUND: Dietary intervention success requires strong participant adherence, but very few studies have examined factors related to both short-term and long-term adherence. A better understanding of predictors of adherence is necessary to improve the design and execution of dietary intervention trials. This study was designed to identify participant characteristics at baseline and study features that predict short-term and long-term adherence with interventions promoting the Mediterranean-type diet (MedDiet) in the PREvención con DIeta MEDiterránea (PREDIMED) randomized trial...
2016: International Journal of Behavioral Nutrition and Physical Activity
Ramon Estruch, Miguel Angel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Montserrat Fitó, Gemma Chiva-Blanch, Miquel Fiol, Enrique Gómez-Gracia, Fernando Arós, José Lapetra, Lluis Serra-Majem, Xavier Pintó, Pilar Buil-Cosiales, José V Sorlí, Miguel A Muñoz, Josep Basora-Gallisá, Rosa María Lamuela-Raventós, Mercè Serra-Mir, Emilio Ros
BACKGROUND: Because of the high density of fat, high-fat diets are perceived as likely to lead to increased bodyweight, hence health-care providers are reluctant to recommend them to overweight or obese individuals. We assessed the long-term effects of ad libitum, high-fat, high-vegetable-fat Mediterranean diets on bodyweight and waist circumference in older people at risk of cardiovascular disease, most of whom were overweight or obese. METHODS: PREDIMED was a 5 year parallel-group, multicentre, randomised, controlled clinical trial done in primary care centres affiliated to 11 hospitals in Spain...
August 2016: Lancet Diabetes & Endocrinology
Pilar Buil-Cosiales, Estefania Toledo, Jordi Salas-Salvadó, Itziar Zazpe, Marta Farràs, Francisco Javier Basterra-Gortari, Javier Diez-Espino, Ramon Estruch, Dolores Corella, Emilio Ros, Amelia Marti, Enrique Gómez-Gracia, Manuel Ortega-Calvo, Fernando Arós, Manuel Moñino, Lluis Serra-Majem, Xavier Pintó, Rosa Maria Lamuela-Raventós, Nancy Babio, Jose I Gonzalez, Montserrat Fitó, Miguel A Martínez-González
Prospective studies assessing the association between fibre intake or fibre-rich food consumption and the risk of CVD have often been limited by baseline assessment of diet. Thus far, no study has used yearly repeated measurements of dietary changes during follow-up. Moreover, previous studies included healthy and selected participants who did not represent subjects at high cardiovascular risk. We used yearly repeated measurements of diet to investigate the association between fibre intake and CVD in a Mediterranean cohort of elderly adults at high cardiovascular risk...
August 2016: British Journal of Nutrition
Alexander Medina-Remón, Rosa Casas, Anna Tressserra-Rimbau, Emilio Ros, Miguel A Martínez-González, Montserrat Fitó, Dolores Corella, Jordi Salas-Salvadó, Rosa M Lamuela-Raventos, Ramón Estruch
BACKGROUND AND AIMS: High dietary polyphenol intake is associated with reduced all-cause mortality and lower incidence of cardiovascular events. However, the mechanisms involved are not fully understood. The aim of this sub-study of the PREDIMED (Prevention with Mediterranean diet) trial was to analyze the relationship of polyphenol intake measured by total urinary polyphenol excretion (TPE), with circulating inflammatory biomarkers and cardiovascular risk factors in elderly individuals...
April 21, 2016: British Journal of Clinical Pharmacology
Marta Guasch-Ferré, Yan Zheng, Miguel Ruiz-Canela, Adela Hruby, Miguel A Martínez-González, Clary B Clish, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó, Courtney Dennis, Isabel M Morales-Gil, Fernando Arós, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Frank B Hu, Jordi Salas-Salvadó
BACKGROUND: Previous studies have suggested that metabolite profiles of elevated acylcarnitines were associated with increased risk of cardiovascular disease (CVD) in populations with established coronary disease. However, to our knowledge, this association has not been evaluated in the context of primary cardiovascular prevention. OBJECTIVES: We evaluated the association between 28 plasma acylcarnitine species and risk of incident CVD and the potential modifying effect of Mediterranean diet (MedDiet) interventions...
June 2016: American Journal of Clinical Nutrition
Nerea Becerra-Tomás, Nancy Babio, Miguel Ángel Martínez-González, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó, Lluís Serra-Majem, Itziar Salaverria, Rosa M Lamuela-Raventós, José Lapetra, Enrique Gómez-Gracia, Miguel Fiol, Estefanía Toledo, José V Sorlí, Maria Roser Pedret-Llaberia, Jordi Salas-Salvadó
BACKGROUND & AIMS: Few studies have assessed the association between consumption of red meat (RM) and processed red meats (PRM) and the incidence of metabolic syndrome (MetS) and results have been inconsistent. We investigated associations between total consumption of meat and its subtypes and incident MetS and estimated the effect of substituting RM or PRM for alternative protein-rich foods. METHODS: We analyzed 1868 participants (55-80 years-old) recruited into the PREDIMED study who had no MetS at baseline and were followed for a median of 3...
March 31, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Sonia García-Calzón, Miguel A Martínez-González, Cristina Razquin, Fernando Arós, José Lapetra, J Alfredo Martínez, Guillermo Zalba, Amelia Marti
BACKGROUND & AIMS: A healthy lifestyle has been associated with longer telomeres, but whether Mediterranean Diet (MeDiet) affect telomere length (TL) has not been fully elucidated yet. Our aim was to assess the relationship between MeDiet and TL in high cardiovascular risk subjects in the context of a randomized nutritional intervention trial. METHODS: We assessed 520 participants (55-80 years, 55% women) from the PREDIMED-NAVARRA trial. Leukocyte TL was measured by qPCR at baseline and after 5 years of a dietary intervention program where subjects were randomly assigned to a low-fat control diet or to two MeDiets, one supplemented with extra virgin olive oil (MeDiet-EVOO) and the other with mixed nuts (MeDiet-nuts)...
April 1, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Gemma Chiva-Blanch, Javier Crespo, Rosa Suades, Gemma Arderiu, Teresa Padro, Gemma Vilahur, Judith Cubedo, Dolores Corella, Jordi Salas-Salvadó, Fernando Arós, Miguel-Angel Martínez-González, Emilio Ros, Montse Fitó, Ramon Estruch, Lina Badimon
Circulating microparticles (cMPs) are small phospholipid-rich microvesicles shed by activated cells that play a pivotal role in cell signalling related to the pathogenesis of atherothrombosis. We aimed to investigate the prognostic value of cMPs released from different vascular cells for cardiovascular event (CVE) presentation in asymptomatic patients at high cardiovascular risk factors under nutritional and pharmacologic treatment. This is a nested case-control study of 50 patients from the five-year follow-up prospective PREDIMED trial enrolled in the nuts arm of the Mediterranean diet (MedDiet-nuts)...
July 4, 2016: Thrombosis and Haemostasis
L Vuolo, L Barrea, M C Savanelli, S Savastano, M Rubino, E Scarano, M Soprano, M Illario, A Colao, C Di Somma
BACKGROUND: Bone impairment and malnutrition are associated with significant disability and mortality. PERSSILAA is an European project developing health services to detect and prevent frailty in older adults by addressing cognitive, physical and nutritional. METHODS: Subjects underwent anthropometric measurements, calcaneal quantitative ultrasound (QUS) scan and PREDIMED (PREvención con DIeta MEDiterránea) questionnaire. AIM: To investigate the association between adherence to the Mediterranean Diet (MD) and bone health...
December 2015: Translational Medicine @ UniSa
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