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https://www.readbyqxmd.com/read/28922692/phosphodiesterase-4-inhibitors-for-chronic-obstructive-pulmonary-disease
#1
REVIEW
Jimmy Chong, Bonnie Leung, Phillippa Poole
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with cough, sputum production or dyspnoea and a reduction in lung function, quality of life and life expectancy. Apart from smoking cessation, there are no other treatments that slow lung function decline. Roflumilast and cilomilast are oral phosphodiesterase 4 (PDE4) inhibitors proposed to reduce the airway inflammation and bronchoconstriction seen in COPD. This is an update of a Cochrane review first published in 2011 and updated in 2013...
September 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28918179/-analysis-of-quality-of-life-in-patients-with-chronic-obstructive-pulmonary-disorder-copd-who-give-up-smoking
#2
C A Jimenez-Ruiz, J F Pascual Lledó, A Cícero Guerrero, M Cristóbal Fernández, M Mayayo Ulibarri, C Villar Laguna
OBJECTIVE: To analyse the impact in COPD patients' quality of life who stop smoking. PATIENTS AND METHODS: We studied a group of COPD patients who received smoking cessation treatment. All patients were treated with bronchodilators according to the severity of their disorder. This treatment was not changed during the process of smoking cessation. Patients received a smoking cessation programme that consisted of a combination of pharmacological treatment plus cognitive-behavioural treatment...
September 13, 2017: Semergen
https://www.readbyqxmd.com/read/28884423/electronic-cigarette-use-in-us-adults-at-risk-for-or-with-copd-analysis-from-two-observational-cohorts
#3
Russell P Bowler, Nadia N Hansel, Sean Jacobson, R Graham Barr, Barry J Make, MeiLan K Han, Wanda K O'Neal, Elizabeth C Oelsner, Richard Casaburi, Igor Barjaktarevic, Chris Cooper, Marilyn Foreman, Robert A Wise, Dawn L DeMeo, Edwin K Silverman, William Bailey, Kathleen F Harrington, Prescott G Woodruff, M Bradley Drummond
BACKGROUND: Electronic cigarettes (e-cigarettes) are battery-operated nicotine-delivery devices used by some smokers as a cessation tool as well as by never smokers. OBJECTIVE: To determine the usage of e-cigarettes in older adults at risk for or with chronic obstructive pulmonary disease (COPD). DESIGN: Prospective cohorts. PARTICIPANTS: COPDGene (N = 3536) and SPIROMICS (N = 1060) subjects who were current or former smokers aged 45-80...
September 7, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28877023/airway-mucin-concentration-as-a-marker-of-chronic-bronchitis
#4
Mehmet Kesimer, Amina A Ford, Agathe Ceppe, Giorgia Radicioni, Rui Cao, C William Davis, Claire M Doerschuk, Neil E Alexis, Wayne H Anderson, Ashley G Henderson, R Graham Barr, Eugene R Bleecker, Stephanie A Christenson, Christopher B Cooper, MeiLan K Han, Nadia N Hansel, Annette T Hastie, Eric A Hoffman, Richard E Kanner, Fernando Martinez, Robert Paine, Prescott G Woodruff, Wanda K O'Neal, Richard C Boucher
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitic and emphysematous components. In one biophysical model, the concentration of mucin on the airway surfaces is hypothesized to be a key variable that controls mucus transport in healthy persons versus cessation of transport in persons with muco-obstructive lung diseases. Under this model, it is postulated that a high mucin concentration produces the sputum and disease progression that are characteristic of chronic bronchitis...
September 7, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28862879/chronic-obstructive-pulmonary-disease-in-hispanics-a-9-year-update
#5
Alejandro Díaz, Bartolomé Celli, Juan C Celedón
Hispanics are the largest minority in the U.S., now encompassing 56.6 million people. A Hispanic or Latino is an individual whose ancestry can be traced to Spain or territories previously under Spanish control. The Hispanic population in the U.S. and Latin America is very diverse for country of origin, nativity, and racial ancestry. Over the last nine years, our knowledge of COPD in Hispanics has improved, due to a better understanding of differences in COPD burden and risk factors across Hispanic subgroups, development of subgroup-specific spirometry reference equations, genetic studies, and better knowledge of barriers and needs in the diagnosis and management of COPD in the Hispanic population...
September 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28860884/chronic-obstructive-pulmonary-disease-in-patients-with-lung-cancer-prevalence-impact-and-management-challenges
#6
REVIEW
Dionisios Spyratos, Eleni Papadaki, Sofia Lampaki, Theodoros Kontakiotis
Chronic obstructive pulmonary disease (COPD) and lung cancer share a common etiological factor (cigarette smoking) and usually coexist in everyday clinical practice. The prevalence of COPD among newly diagnosed patients with lung cancer sometimes exceeds 50%. COPD is an independent risk factor (2-4 times higher than non-COPD subjects) for lung cancer development. The presence of emphysema in addition to other factors (e.g., smoking history, age) could be incorporated into risk scores in order to define the most appropriate target group for lung cancer screening using low-dose computed tomography...
2017: Lung Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28803293/-copd-smoking-cessation-is-the-most-important-therapy
#7
REVIEW
Thomas Hering
No abstract text is available yet for this article.
August 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28794621/counseling-for-health-behavior-change-in-people-with-copd-systematic-review
#8
REVIEW
Marie T Williams, Tanja W Effing, Catherine Paquet, Carole A Gibbs, Hayley Lewthwaite, Lok Sze Katrina Li, Anna C Phillips, Kylie N Johnston
Counseling has been suggested as a promising approach for facilitating changes in health behavior. The aim of this systematic review of counseling interventions for people with COPD was to describe: 1) counseling definitions, 2) targeted health behaviors, 3) counseling techniques and 4) whether commonalities in counseling techniques were associated with improved health behaviors. Ten databases were searched for original randomized controlled trials which included adults with COPD, used the term "counseling" as a sole or component of a multifaceted intervention and were published in the previous 10 years...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28790283/-postoperative-atelectasis-and-pneumonia-after-general-thoracic-surgery
#9
Yasushi Hoshikawa, Daisuke Tochii
Atelectasis and pneumonia are common postoperative complications occurred in patients undergoing general thoracic surgery. Strategies to reduce the risk of postoperative pulmonary complications including these 2 disorders consist of smoking cessation, optimization of underlying chronic obstructive pulmonary disease( COPD), adequate pain control, intensive oral care, and so on. Preoperative treatments for patients with COPD are the same as those for COPD patients being not about to have surgery, which mainly consist of long-acting bronchodilators and pulmonary rehabilitation...
July 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28777450/self-management-interventions-including-action-plans-for-exacerbations-versus-usual-care-in-patients-with-chronic-obstructive-pulmonary-disease
#10
REVIEW
Anke Lenferink, Marjolein Brusse-Keizer, Paul Dlpm van der Valk, Peter A Frith, Marlies Zwerink, Evelyn M Monninkhof, Job van der Palen, Tanja W Effing
BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) self-management interventions should be structured but personalised and often multi-component, with goals of motivating, engaging and supporting the patients to positively adapt their behaviour(s) and develop skills to better manage disease. Exacerbation action plans are considered to be a key component of COPD self-management interventions. Studies assessing these interventions show contradictory results. In this Cochrane Review, we compared the effectiveness of COPD self-management interventions that include action plans for acute exacerbations of COPD (AECOPD) with usual care...
August 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28774206/how-do-patients-conceptualize-chronic-obstructive-pulmonary-disease
#11
R E Goldman, L Mennillo, P Stebbins, D R Parker
Chronic obstructive pulmonary disease (COPD) is a leading cause of death in the United States, yet even at risk or diagnosed patients misunderstand COPD and its consequences for their quality of life and mortality. This study explored how patients conceptualize the causes, symptoms, consequences, treatment, and risk for developing COPD. The study consisted of six focus groups: 39 participants who were adults > 40 and current smoker or have COPD symptoms, family history, or exposures. Although many participants had some familiarity with the breathing, lung function, physical, emotional, and social consequences of COPD, confusion and misunderstanding prevailed...
August 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28766107/examining-of-thallium-in-cigarette-smokers
#12
Amir Ghaderi, Payam NasehGhafoori, Morad Rasouli-Azad, Mojtaba Sehat, Fateme Mehrzad, Mina Nekuei, Jan Aaseth, Hamid Reza Banafshe, Omid Mehrpour
Smoking is one of the sources of thallium which is considered as a toxic heavy metal. The aim of this study was to determine urinary thallium levels and related variables in smokers, compared to a control group. The study was conducted on 56 participants who had smoked continuously during the year before they were referred to Kashan Smoking Cessation Clinic. Fifty-three nonsmokers who were family members or friends of the smokers were selected as the control group. Urinary thallium was measured in both groups (n = 109) using atomic absorption spectrophotometry...
August 1, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28758847/sex-related-differences-in-bronchial-parameters-and-pulmonary-function-test-results-in-patients-with-chronic-obstructive-pulmonary-disease-based-on-three-dimensional-quantitative-computed-tomography
#13
Yan Li, Yong-Liang Dai, Nan Yu, You-Min Guo
Objective This study was performed to evaluate the effect of sex on bronchial parameters and the predicted forced expiratory volume in 1 s expressed as a percentage of the forced vital capacity (FEV1% pred) on pulmonary function testing. Methods The data of 359 patients with chronic obstructive pulmonary disease (COPD) with available FEV1% pred and computed tomography (CT) images were retrospectively reviewed. FACT-Digital lung TM software (DeXin, Xi'an, China) was used to perform fully automated three-dimensional CT quantitative measurements of the bronchi...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28750556/the-quebec-respiratory-health-education-network-integrating-a-model-of-self-management-education-in-copd-primary-care
#14
Jean Bourbeau, Raquel Farias, Pei Zhi Li, Guylaine Gauthier, Livia Battisti, Valérie Chabot, Marie-France Beauchesne, Denis Villeneuve, Patricia Côté, Louis-Philippe Boulet
The objective of this study is to evaluate whether a chronic obstructive pulmonary disease (COPD) self-management education program with coaching of a case manager improves patient-related outcomes and leads to practice changes in primary care. COPD patients from six family medicine clinics (FMCs) participated in a 1-year educational program offered by trained case managers who focused on treatment adherence, inhaler techniques, smoking cessation, and the use of an action plan for exacerbations. Health-care utilization, health-related quality of life (HRQL), treatment adherence, inhaler technique, and COPD knowledge were assessed at each visit with validated questionnaires...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28747961/determinants-of-nicotine-dependence-in-chronic-obstructive-pulmonary-disease
#15
Yun Su Sim, Jin Hwa Lee, Ki Uk Kim, Seung Won Ra, Hye Yun Park, Chang-Hoon Lee, Deog Kyeom Kim, Kyeong-Cheol Shin, Sang Haak Lee, Hun Gyu Hwang, Joong Hyun Ahn, Yong Bum Park, Yu-Il Kim, Kwang Ha Yoo, Ina Jeong, Yeon-Mok Oh, Sang-Do Lee
BACKGROUND: Smoking cessation is the most powerful intervention to modify progress of chronic obstructive pulmonary disease (COPD), and nicotine dependence is one of the most important determinants of success or failure in smoking cessation. We evaluated nicotine dependence status and investigated factors associated with moderate to high nicotine dependence in patients with COPD. METHODS: We included 53 current smokers with COPD in the Korean Obstructive Lung Disease II cohort enrolled between January 2014 and March 2016...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28740672/effectiveness-of-perioperative-pulmonary-rehabilitation-in-thoracic-surgery
#16
Attila Vagvolgyi, Zsolt Rozgonyi, Maria Kerti, Paul Vadasz, Janos Varga
BACKGROUND: Functional condition is crucial for operability of patients with lung cancer and/or chronic respiratory diseases. The aim of the study was to measure changes of functional and quality of life parameters in terms of the effectiveness of perioperative pulmonary rehabilitation (PR). METHODS: A total of 208 COPD patients (age: 63±9 years, man/woman: 114/94, FEV1: 62±14%pred) participated in a perioperative PR program. The indication was primary lung cancer in 72% of the patients...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28667909/graphical-review-the-redox-dark-side-of-e-cigarettes-exposure-to-oxidants-and-public-health-concerns
#17
REVIEW
Hua Cai, Chen Wang
Since the initial marketing in 2005, the use of e-cigarettes has increased exponentially. Nonetheless, accumulating evidence has demonstrated the ineffectiveness of e-cigarettes in leading to smoking cessation, and decreasing the adverse health impacts of cigarette smoking. The number of adolescents adapted to e-cigarettes has been increasing substantially each year, and this adaptation has promoted openness to tobacco smoking. The present review discusses controversies regarding the smoking cessation effects of e-cigarettes, recent governmental policies and regulations of e-cigarette use, toxic components and vaporization products of e-cigarettes, and the novel molecular mechanisms underlying the adverse health impacts of e-cigarettes leading to oxidative stress in target tissues, and consequent development of cardiopulmonary diseases (i...
May 25, 2017: Redox Biology
https://www.readbyqxmd.com/read/28651854/estimating-the-effect-of-differing-assumptions-on-the-population-health-impact-of-introducing-a-reduced-risk-tobacco-product-in-the-usa
#18
Peter N Lee, John S Fry, John F Hamling, Zheng Sponsiello-Wang, Gizelle Baker, Rolf Weitkunat
We use Population Health Impact Modelling to assess effects on tobacco prevalence and mortality of introducing a Reduced Risk Tobacco Product (RRP). Simulated samples start in 1990 with a US-representative smoking prevalence. Individual tobacco histories are updated annually until 2010 using estimated probabilities of switching between never/current/former smoking where the RRP is not introduced, with current users subdivided into cigarette/RRP/dual users where it is. RRP-related mortality reductions from lung cancer, IHD, stroke and COPD are derived from the histories and the assumed relative risks of the RRP...
June 24, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28647626/smoking-cessation-rates-among-patients-undergoing-vascular-surgery-in-a-canadian-center
#19
Seamus Mark McHugh, Naomi Eisenberg, Janice Montbriand, Graham Roche-Nagle
BACKGROUND: Smoking is the single most important modifiable risk factor for patients with vascular disease. The aim of this study was to determine the prevalence of smoking and cessation rates among patients undergoing vascular surgery in a Canadian center. METHODS: As part of the Vascular Quality Initiative, a prospectively maintained database was used to identify the patients undergoing vascular surgery between 2010 and 2013. Smoking prevalence data were collated preprocedure, postprocedure, and at year follow-up after intervention at a median of 13 months (mean = 14...
June 22, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28646217/why-do-physicians-lack-engagement-with-smoking-cessation-treatment-in-their-copd-patients-a-multinational-qualitative-study
#20
Eva Anne Marije van Eerd, Mette Bech Risør, Mark Spigt, Maciek Godycki-Cwirko, Elena Andreeva, Nick Francis, Anja Wollny, Hasse Melbye, Onno van Schayck, Daniel Kotz
Smoking cessation is the only effective intervention to slow down the accelerated decline in lung function in smokers with chronic obstructive pulmonary disease. Nevertheless, physicians often do not routinely provide evidence-based smoking cessation treatment to their patients. To understand underlying reasons, we explored how physicians engage in smoking cessation treatment in their chronic obstructive pulmonary disease patients. In total, 21 focus group discussions were held with general practitioners and pulmonologists in seven different countries in Europe and Asia...
June 23, 2017: NPJ Primary Care Respiratory Medicine
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