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smoking cessation COPD

Gimano D Amatngalim, Jasmijn A Schrumpf, Fernanda Dishchekenian, Tinne C J Mertens, Dennis K Ninaber, Abraham C van der Linden, Charles Pilette, Christian Taube, Pieter S Hiemstra, Anne M van der Does
Research question : It is currently unknown how cigarette smoke-induced airway remodelling affects highly expressed respiratory epithelial defence proteins and thereby mucosal host defence. Methods: Localization of a selected set of highly expressed respiratory epithelial host defence proteins was assessed in well-differentiated primary bronchial epithelial cell (PBEC) cultures. Next, PBEC were cultured at the air-liquid interface and during differentiation for 2-3 weeks daily exposed to whole cigarette smoke...
March 15, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Yuan Ding, Kent A Nielsen, Bruno P Nielsen, Niels W Bøje, Rainer H Müller, Sung Min Pyo
Nicotine, obtained from tobacco leaves, has been used to promote the cessation of smoking and reduce the risk of COPD and lung cancer. Incorporating the active in lipid nanoparticles is an effective tool to minimize its irritation potential and to use the particles as intermediate to produce final products. However, as a hydrophilic active, it is a challenge to prepare nicotine loaded lipid nanoparticles with high drug loading. In this study, lipid-drug-conjugates (LDC) were formed by nicotine and different fatty acids to enable the production of sufficiently loaded nicotine lipid nanoparticles...
March 12, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Christian Viniol, Claus F Vogelmeier
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. While COPD is a mainly chronic disease, a substantial number of patients suffer from exacerbations. Severe exacerbations are related to a significantly worse survival outcome. This review summarises the current knowledge on the different aspects of COPD exacerbations. The impact of risk factors and triggers such as smoking, severe airflow limitation, bronchiectasis, bacterial and viral infections and comorbidities is discussed...
March 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
Eun Mi Chun
Quitting smoking helps smokers maintain their health and extend their lifespan by 10 or more years. Treatment strategies for smoking cessation should be tailored to individual smokers with special needs based on their specific circumstances. It is recommended that pregnant women adopt smoking cessation through counseling and behavioral interventions because the safety of medications has yet to be established. Counseling is the main strategy for smoking cessation in adolescents and nicotine replacement therapy can be used with caution in individuals with serious nicotine dependence...
March 7, 2018: Tuberculosis and Respiratory Diseases
Kenichiro Tanaka, Hideaki Senjyu, Yuichi Tawara, Takako Tanaka, Masaharu Asai, Mitsuru Tabusadani, Sumihisa Honda, Terumitsu Sawai, Ryo Kozu
Objective The early detection and treatment of COPD requires comprehensive follow-up over a long period. The aim of this study was to determine the effects of a comprehensive long-term intervention system developed by the COPD Task Force for a rural city in Japan during a 7-year period. Methods This prospective, community-based longitudinal study encompassed 2006-2013 in Matsuura City, Japan. Primary and secondary screenings were performed for the early diagnosis and treatment of COPD. Individuals diagnosed with COPD were managed by the COPD Task Force's comprehensive early intervention system...
March 9, 2018: Internal Medicine
Oliver T Mytton, Christopher Jackson, Arno Steinacher, Anna Goodman, Claudia Langenberg, Simon Griffin, Nick Wareham, James Woodcock
BACKGROUND: The National Health Service (NHS) Health Check programme was introduced in 2009 in England to systematically assess all adults in midlife for cardiovascular disease risk factors. However, its current benefit and impact on health inequalities are unknown. It is also unclear whether feasible changes in how it is delivered could result in increased benefits. It is one of the first such programmes in the world. We sought to estimate the health benefits and effect on inequalities of the current NHS Health Check programme and the impact of making feasible changes to its implementation...
March 2018: PLoS Medicine
Ofra Kalter-Leibovici, Michal Benderly, Laurence S Freedman, Galit Kaufman, Tchiya Molcho Falkenberg Luft, Havi Murad, Liraz Olmer, Meri Gluch, David Segev, Avi Gilad, Said Elkrinawi, Tali Cukierman-Yaffe, Baruch Chen, Orit Jacobson, Calanit Key, Mordechai Shani, Gershon Fink
RATIONALE: The efficacy of disease management programs in the treatment of patients with chronic obstructive pulmonary disease (COPD) remains uncertain. OBJECTIVE: To study the effect of disease management (DM) added to recommended care (RC) in ambulatory COPD patients. MEASUREMENTS AND MAIN RESULTS: In this trial, 1,202 COPD patients (age >40 years), with moderate to very severe airflow limitation were randomly assigned either to DM plus RC (study intervention) or to RC alone (control intervention)...
March 1, 2018: American Journal of Respiratory and Critical Care Medicine
Cristina Martínez, Ciro Casanova, Juan P de-Torres, José M Marín, Pilar de Lucas, Antonia Fuster, Borja G Cosío, Myriam Calle, Germán Peces-Barba, Ingrid Solanes, Ramón Agüero, Nuria Feu-Collado, Inmaculada Alfageme, Amparo Romero Plaza, Eva Balcells, Alfredo de Diego, Margarita Marín Royo, Amalia Moreno, Antonia Llunel Casanova, Juan B Galdiz, Rafael Golpe, Celia Lacárcel Bautista, Carlos Cabrera, Alicia Marin, Joan B Soriano, Jose Luis Lopez-Campos
BACKGROUND: Despite the existing evidence-based smoking cessation interventions, chances of achieving that goal in real-life are still low among COPD patients. We sought to evaluate the clinical consequences of changes in smoking habits in a large cohort of COPD patients. METHODS: CHAIN is a Spanish multicenter study carried out at pulmonary clinics including active and former smokers with COPD. Smoking status was certified by clinical history and co-oximetry. Clinical presentation and disease impact were recorded via validated questionnaires, including the London Chest Activity of Daily Living (LCADL) and the Hospital Anxiety and Depression Scale (HADS)...
February 21, 2018: Chest
Maria B Ospina, Marta Michas, Lesly Deuchar, Richard Leigh, Mohit Bhutani, Brian H Rowe, Darcy Marciniuk, Donna Goodridge, Gail Dechman, Jean Bourbeau, Meyer Balter, Pat Camp, Paul Hernandez, Roger S Goldstein, Michael K Stickland
Introduction: Hospital and emergency department discharge for patients with chronic obstructive pulmonary disease (COPD) is often poorly organised. We developed a patient-centred, evidence-based and consensus-based discharge care bundle for patients with acute exacerbations of COPD. Methods: A purposeful sample of clinicians and patients were invited to participate in a two-round Delphi study (July-November 2015). In round 1, participants rated on a seven-point Likert scale (1=not at all important; 7=extremely important) the importance of 29 unique COPD care actions...
2018: BMJ Open Respiratory Research
Riikka E Lemmetyinen, Jussi V Karjalainen, Anna But, Risto L O Renkonen, Juha R Pekkanen, Sanna K Toppila-Salmi, Jari K Haukka
BACKGROUND: Higher all-cause mortality in asthmatics has been shown previously. Polysensitization is associated with higher morbidity among asthmatic children, and allergic rhinitis and/or allergic conjunctivitis (AR/AC) is associated with higher morbidity in adult asthmatics. Little is known about the effect of AR/AC and other factors on mortality among adult asthmatics. The aim was to study mortality and its risk factors in adults with and without asthma. METHODS: We randomly selected 1648 asthmatics with age over 30 years from national registers and matched the asthma sample with one or two controls...
February 20, 2018: Allergy
Neil M Davies, Gemma M J Taylor, Amy E Taylor, Timothy Jones, Richard M Martin, Marcus R Munafò, Frank Windmeijer, Kyla H Thomas
AIMS: To investigate whether smokers prescribed varenicline had lower risks of serious ill-health during the 4 years following treatment compared with those prescribed nicotine replacement therapy (NRT). DESIGN: Observational cohort study of electronic medical records. SETTING: A total of 370 UK general practices sampled from the Clinical Practice Research Datalink. PARTICIPANTS: A total of 126 718 patients aged 18 and over who were issued smoking cessation prescriptions between 1 September 2006 and 31 March 2014...
February 20, 2018: Addiction
Naofumi Kameyama, Shotaro Chubachi, Ahmed E Hegab, Hiroyuki Yasuda, Shizuko Kagawa, Akihiro Tsutsumi, Koichi Fukunaga, Masayuki Shimoda, Yae Kanai, Kenzo Soejima, Tomoko Betsuyaku
Lung cancer and chronic obstructive pulmonary disease (COPD) are leading causes of morbidity and mortality worldwide, and cigarette smoking is a main risk factor for both. The presence of emphysema, an irreversible lung disease, further raises the risk of lung cancer in COPD patients. The mechanisms involved in smoke-induced tumorigenesis and emphysema are not fully understood, attributable to a lack of appropriate animal models. Here, we optimized a model of cigarette smoke (CS)-induced lung cancer and emphysema in A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent carcinogen...
February 14, 2018: American Journal of Respiratory Cell and Molecular Biology
Michael Fricker, Bridie J Goggins, Sean Mateer, Bernadette Jones, Richard Y Kim, Shaan L Gellatly, Andrew G Jarnicki, Nicholas Powell, Brian G Oliver, Graham Radford-Smith, Nicholas J Talley, Marjorie M Walker, Simon Keely, Philip M Hansbro
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract (GIT). Cigarette smoke (CS) exposure and chronic obstructive pulmonary disease (COPD) are risk factors for CD, although the mechanisms involved are poorly understood. We employed a mouse model of CS-induced experimental COPD and clinical studies to examine these mechanisms. Concurrent with the development of pulmonary pathology and impaired gas exchange, CS-exposed mice developed CD-associated pathology in the colon and ileum, including gut mucosal tissue hypoxia, HIF-2 stabilization, inflammation, increased microvasculature, epithelial cell turnover, and decreased intestinal barrier function...
February 8, 2018: JCI Insight
Paolo Banfi, Antonietta Cappuccio, Maura E Latella, Luigi Reale, Elisa Muscianisi, Maria Giulia Marini
Purpose: Poor adherence to therapy and the failure of current smoking cessation programs demonstrate that the current management of COPD can be improved, and it is necessary to educate physicians about new approaches for taking care of patients. Parallel chart is a narrative medicine tool that improves the doctor-patient relationship by asking physicians to write about their patients' lives, thereby encouraging reflective thoughts on care. Patients and methods: Between October 2015 and March 2016, 50 Italian pulmonologists were involved in the collection of parallel charts of anonymous patients with COPD...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Inger Kull, Björn Ställberg
Updated criterias for an asthma/COPD clinic in primary care based on Swedish guidelines We here present updated criterias for an asthma/COPD clinic in primary care based on Swedish guidelines and an estimate of the time required for its tasks. Certified staff should assist in diagnosis and follow-up of asthma/COPD patients, provide patient education, provide and follow up written management plans, facilitate smoking cessation in patients and parents of children with asthma, evaluate symptoms with validated tools (ACT, CAT), and assess and support physical activity...
January 29, 2018: Läkartidningen
Hanna Sandelowsky, Natalia Natalishvili, Ingvar Krakau, Sonja Modin, Björn Ställberg, Anna Nager
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a common cause of suffering and death. Evidence-based management of COPD by general practitioners (GPs) is crucial for decreasing the impact of the disease. Efficient strategies include early diagnosis, smoking cessation and multimodal treatment. AIM: To describe knowledge about and skills for managing COPD in GPs in Sweden. METHODS: Prior to COPD education (the PRIMAIR Study), GPs at primary health care centers (PHCCs) in Stockholm replied to 13 written, patient-case based, multiple choice and free-text questions about COPD...
January 15, 2018: Scandinavian Journal of Primary Health Care
Marcus Stegberg, Mikael Hasselgren, Scott Montgomery, Karin Lisspers, Björn Ställberg, Christer Janson, Josefin Sundh
Introduction: Our aim was to investigate changes in smoking prevalence, smoking cessation support and factors associated with successful smoking cessation in patients with asthma and COPD. Methods: Questionnaires about available smoking cessation resources were completed by 54 primary health-care centers and 14 hospitals in central Sweden in 2005 and 2012. Patient data were collected using record reviews and patients questionnaires for two cohorts of randomly selected asthma and COPD patients in 2005 (n = 2306; with a follow up in 2012), and in 2014/2015 (n = 2620)...
2018: European Clinical Respiratory Journal
Jenifer Liang, Michael J Abramson, Nicholas A Zwar, Grant M Russell, Anne E Holland, Billie Bonevski, Ajay Mahal, Kirsten Phillips, Paula Eustace, Eldho Paul, Sally Wilson, Johnson George
OBJECTIVES: To review the accuracy of diagnoses of chronic obstructive pulmonary disease (COPD) in primary care in Australia, and to describe smokers' experiences with and preferences for smoking cessation. DESIGN, SETTING AND PARTICIPANTS: Patients were invited to participate if they were at least 40 years old and had visited participating general practice clinics in Melbourne at least twice during the previous 12 months, reported being current or ex-smokers with a smoking history of at least 10 pack-years, or were being managed for COPD...
January 15, 2018: Medical Journal of Australia
Umur Hatipoğlu, James K Stoller
PURPOSE OF REVIEW: Oxygen therapy was the first treatment shown to prolong life in patients with chronic obstructive pulmonary disease (COPD) and has been joined by lung volume reduction surgery in selected patients with emphysema, smoking cessation, and potentially noninvasive ventilation in chronic hypercapneic respiratory failure. Although there is consensus around the survival-enhancing effect of supplemental oxygen (SupplO2) for patients with chronic severe hypoxemia at rest, the impact of SupplO2 for COPD patients with moderate hypoxemia and exertional desaturation had been less clear...
March 2018: Current Opinion in Pulmonary Medicine
Vladimír Koblížek, Karel Hejduk
Chronic obstructive pulmonary disease (COPD) is a leading cause mortality and morbidity globally, with permanently growing prevalence. Expressive underdiagnosis and undertreatment is a general features across all European countries. Individuals with undiagnosed, symptomatic COPD had significantly increased risk of exacerbations, pneumonia, and death. Early smoking cessation is able to reduce the mortality and morbidity burden of newly diagnosed COPD individuals. These findings suggest that better initiatives for early diagnosis and early treatment of COPD are needed...
2018: Vnitr̆ní Lékar̆ství
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