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spinal cord injury AND children

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https://www.readbyqxmd.com/read/27909623/distribution-of-interstitial-cells-of-cajal-in-the-bladders-of-fetal-rats-with-retinoic-acid-induced-myelomeningocele
#1
Ali Tekin, Osman Zeki Karakuş, Gülce Hakgüder, Oğuz Ateş, Erdener Özer, Mustafa Olguner, Feza Miraç Akgür
OBJECTIVE: Myelomeningocele (MMC) is one of the most common reason of neurogenic bladder dysfunction in children. Although neurogenic bladder dysfunction occurrence is related with bladder innervation, also there are some changes seen in the smooth muscle and neural cells of the bladder. Interstitial cells of Cajal (ICC) are the pacemaker cells found in organs with peristaltic activity. Although it has been shown that ICC are diminished in the rat urinary bladder with traumatic spinal cord injury, there is no data about ICC in fetal rat bladders with MMC...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27909135/new-radiological-parameters-for-the-assessment-of-atlantoaxial-instability-in-children-with-down-syndrome-the-normal-values-and-the-risk-of-spinal-cord-injury
#2
N Nakamura, Y Inaba, Y Aota, M Oba, J Machida, N Aida, K Kurosawa, T Saito
AIMS: To determine the normal values and usefulness of the C1/4 space available for spinal cord (SAC) ratio and C1 inclination angle, which are new radiological parameters for assessing atlantoaxial instability in children with Down syndrome. PATIENTS AND METHODS: We recruited 272 children with Down syndrome (including 14 who underwent surgical treatment), and 141 children in the control group. All were aged between two and 11 years. The C1/4 SAC ratio, C1 inclination angle, atlas-dens interval (ADI), and SAC were measured in those with Down syndrome, and the C1/4 SAC ratio and C1 inclination angle were measured in the control group...
December 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27898492/growth-hormone-regulates-the-sensitization-of-developing-peripheral-nociceptors-during-cutaneous-inflammation
#3
Xiaohua Liu, Kathryn J Green, Zachary K Ford, Luis F Queme, Peilin Lu, Jessica L Ross, Frank B Lee, Aaron T Shank, Renita C Hudgins, Michael P Jankowski
Cutaneous inflammation alters the function of primary afferents and gene expression in the affected dorsal root ganglia (DRGs). However specific mechanisms of injury-induced peripheral afferent sensitization and behavioral hypersensitivity during development are not fully understood. Recent studies in children suggest a potential role for growth hormone (GH) in pain modulation. GH modulates homeostasis and tissue repair after injury, but how GH effects nociception in neonates is not known. To determine if GH played a role in modulating sensory neuron function and hyper-responsiveness during skin inflammation in young mice, we examined behavioral hypersensitivity and the response properties of cutaneous afferents using an ex vivo hairy skin-saphenous nerve-dorsal root ganglion (DRG)-spinal cord preparation...
November 18, 2016: Pain
https://www.readbyqxmd.com/read/27889817/paediatric-spinal-cord-infarction-a-review-of-the-literature-and-two-case-reports
#4
Asim Sheikh, Daniel Warren, Anne-Marie Childs, John Russell, Mark Liddington, Velupandian Guruswamy, Paul Chumas
Ischemic spinal cord infarction is rare in the paediatric population, and when it does occur, it is usually associated with traumatic injury. Other potential causes include congenital cardiovascular malformations, cerebellar herniation, thromboembolic disease and infection. Magnetic resonance imaging (MRI) findings can be subtle in the early evaluation of such patients. The outcome is variable and depends on the level and extent of the spinal cord infarct and subsequent rehabilitation. Here, we present two cases of ischemic spinal cord infarction in children...
November 26, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27886885/classification-and-management-of-pediatric-subaxial-cervical-spine-injuries
#5
REVIEW
Casey J Madura, James M Johnston
Appropriate management of subaxial spine injury in children requires an appreciation for the differences in anatomy, biomechanics, injury patterns, and treatment options compared with adult patients. Increased flexibility, weak neck muscles, and cranial disproportion predispose younger children to upper cervical injuries and spinal cord injury without radiographic abnormality. A majority of subaxial cervical spine injuries can be treated nonoperatively. Surgical instrumentation options for children have significantly increased in recent years...
January 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/27884333/c-spine-injury-and-mandibular-fractures-lifesaver-broken-in-two-spots
#6
Michael W Chu, Tahereh Soleimani, Tyler A Evans, Sarah I Fernandez, Leigh Spera, Carrie Klene, Ben L Zarzaur, Sunil S Tholpady
BACKGROUND: Trauma is a leading cause of injury and mortality and may involve mandibular fractures and cervical spine injuries. Manipulation of the spine during trauma protocols and operative treatment has the potential to cause serious spinal cord injuries. The purpose of this study was to identify risk factors associated with cervical spine injury (CSI) in patients with mandibular fractures. METHODS: The National Trauma Databank (2007-2010) was used to identify patients with mandibular fractures...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27869534/training-to-improve-walking-after-pediatric-spinal-cord-injury-a-systematic-review-of-parameters-and-walking-outcomes
#7
Payal Gandhi, Katherine Chan, Mary Verrier, Maureen Pakosh, Kristin Musselman
Walking or locomotor training is often initiated following pediatric spinal cord injury (SCI). There is no synthesis of the literature on interventions targeting walking for pediatric SCI, although this would assist future clinical trials and interventions. To address this need, we completed a systematic review to summarize the who, what, when and how of walking interventions in children with SCI. Participant characteristics, training parameters and walking outcomes with training in pediatric SCI were identified and compared to training parameters and outcomes in adults with SCI...
November 21, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27845358/recommendations-for-the-national-institute-for-neurologic-disorders-and-stroke-spinal-cord-injury-common-data-elements-for-children-and-youth-with-sci
#8
REVIEW
M J Mulcahey, L C Vogel, M Sheikh, J C Arango-Lasprilla, M Augutis, E Garner, E M Hagen, L B Jakeman, E Kelly, R Martin, J Odenkirchen, A Scheel-Sailer, J Schottler, H Taylor, C C Thielen, K Zebracki
STUDY DESIGN: In 2014, the adult spinal cord injury (SCI) common data element (CDE) recommendations were made available. This project was a review of the adult SCI CDE for relevance to children and youth with SCI. OBJECTIVES: The objective of this study was to review the National Institute of Neurologic Disorders and Stroke (NINDS) adult SCI CDEs for relevance to children and youth with SCI. SETTING: International. METHODS: The pediatric working group consisted of international members with varied fields of expertise related to pediatric SCI...
November 15, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27842754/long-term-mechanical-ventilation
#9
REVIEW
Sarina Sahetya, Sarah Allgood, Peter C Gay, Noah Lechtzin
Although precise numbers are difficult to obtain, the population of patients receiving long-term ventilation has increased over the last 20 years, and includes patients with chronic lung diseases, neuromuscular diseases, spinal cord injury, and children with complex disorders. This article reviews the equipment and logistics involved with ventilation outside of the hospital. Discussed are common locations for long-term ventilation, airway and secretion management, and many of the potential challenges faced by individuals on long-term ventilation...
December 2016: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/27826251/immature-spinal-locomotor-output-in-children-with-cerebral-palsy
#10
Germana Cappellini, Yury P Ivanenko, Giovanni Martino, Michael J MacLellan, Annalisa Sacco, Daniela Morelli, Francesco Lacquaniti
Detailed descriptions of gait impairments have been reported in cerebral palsy (CP), but it is still unclear how maturation of the spinal motoneuron output is affected. Spatiotemporal alpha-motoneuron activation during walking can be assessed by mapping the electromyographic activity profiles from several, simultaneously recorded muscles onto the anatomical rostrocaudal location of the motoneuron pools in the spinal cord, and by means of factor analysis of the muscle activity profiles. Here, we analyzed gait kinematics and EMG activity of 11 pairs of bilateral muscles with lumbosacral innervation in 35 children with CP (19 diplegic, 16 hemiplegic, 2-12 years) and 33 typically developing (TD) children (1-12 years)...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27799905/cerebellar-and-spinal-direct-current-stimulation-in-children-computational-modeling-of-the-induced-electric-field
#11
Serena Fiocchi, Paolo Ravazzani, Alberto Priori, Marta Parazzini
Recent studies have shown that the specific application of transcranial direct current stimulation (tDCS) over the cerebellum can modulate cerebellar activity. In parallel, transcutaneous spinal DC stimulation (tsDCS) was found to be able to modulate conduction along the spinal cord and spinal cord functions. Of particular interest is the possible use of these techniques in pediatric age, since many pathologies and injuries, which affect the cerebellar cortex as well as spinal cord circuits, are diffuse in adults as well as in children...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27787884/deaths-due-to-child-abuse-a-6-year-review-of-cases-in-the-cook-county-medical-examiner-s-office
#12
Serenella Serinelli, Ponni Arunkumar, James A Filkins, Lorenzo Gitto
Case files from the Cook County Medical Examiner's Office from 2007 to 2012 were reviewed to analyze homicides due to physical child abuse in children <3 years old. Fatal cases mostly involved younger subjects. Intracranial injuries were the leading cause of death, while death due to extracranial injuries was uncommon. Eyes were involved in most of the cases. Spinal cord was involved in about 1/3 of the cases, mostly in the thoracic area. In some cases, previous injuries were present. There were significant differences in the pattern of injuries between age groups...
October 27, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27781020/stem-cells-in-functional-bladder-engineering
#13
REVIEW
Jakub Smolar, Souzan Salemi, Maya Horst, Tullio Sulser, Daniel Eberli
Conditions impairing bladder function in children and adults, such as myelomeningocele, posterior urethral valves, bladder exstrophy or spinal cord injury, often need urinary diversion or augmentation cystoplasty as when untreated they may cause severe bladder dysfunction and kidney failure. Currently, the gold standard therapy of end-stage bladder disease refractory to conservative management is enterocystoplasty, a surgical enlargement of the bladder with intestinal tissue. Despite providing functional improvement, enterocystoplasty is associated with significant long-term complications, such as recurrent urinary tract infections, metabolic abnormalities, stone formation, and malignancies...
September 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27767903/neurosurgical-sequelae-of-domestic-dog-attacks-in-children
#14
Ramesh Kumar, Frederic W B Deleyiannis, Corbett Wilkinson, Brent R O'Neill
OBJECTIVE The authors' goals in this study were to describe a series of dog attacks on children that required neurosurgical consultation and to better understand the pattern of injuries inflicted, the circumstances that place children at risk for attack, and the dog breeds involved. In addition, the authors review the surgical and medical management of these patients. METHODS The authors performed a retrospective review of all children requiring neurosurgical consultation for dog bite at a regional Level 1 pediatric trauma center over a 15-year period...
October 21, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27766729/testicular-sperm-extraction-for-patients-with-spinal-cord-injury-related-anejaculation-a-single-center-experience
#15
Toshiyuki Iwahata, Takeshi Shin, Yukihito Shimomura, Keisuke Suzuki, Tomohiro Kobayashi, Akane Miyata, Yoshitomo Kobori, Shigehiro Soh, Hiroshi Okada
OBJECTIVES: To present a single-center experience with testicular sperm extraction and intracytoplasmic sperm injection for fathering biological children in patients with ejaculatory dysfunction as a result of spinal cord injury. METHODS: Testicular sperm extraction was carried out in 52 male patients with ejaculatory dysfunction as a result of spinal cord injury. We investigated sperm retrieval rates and pregnancy rates from medical records. Data on age, testicular volume, hormonal status (luteinizing hormone, follicle stimulating hormone and testosterone), and time since spinal cord injury were obtained and analyzed to detect potential associations with the presence of spermatogenesis...
December 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27757567/traumatic-atlanto-occipital-dislocation-in-children-a-case-based-update-on-clinical-characteristics-management-and-outcome
#16
Thomas Beez, Jennifer Brown
BACKGROUND: Atlanto-occipital dislocation (AOD) is a rare but severe sequela of high energy trauma. Children are at increased risk, due to their immature spine and biomechanical characteristics. LITERATURE REVIEW: The prevailing mechanism of injury is motor vehicle collision as passenger. AOD commonly presents with cardiorespiratory arrest, spinal cord injury or cranial nerve deficits. Concomitant injuries, such as traumatic brain injury, are frequently encountered...
October 18, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27752056/evaluation-of-the-walking-index-for-spinal-cord-injury-ii-wisci-ii-in-children-with-spinal-cord-injury-sci
#17
C Calhoun Thielen, C Sadowsky, L C Vogel, H Taylor, L Davidson, J Bultman, J Gaughan, M J Mulcahey
STUDY DESIGN: Mixed methods were used in this study. The appropriateness of the levels of the Walking Index for Spinal Cord Injury II (WISCI-II) for application in children was critically reviewed by physical therapists using the Modified Delphi Technique, and the inter- and intra-rater reliability of the WISCI-II in children was evaluated. OBJECTIVES: To examine the construct validity, and to establish reliability of the WISCI-II related to its use in children with spinal cord injury (SCI)...
October 18, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27749628/cervical-spine-injuries-in-children-associated-with-sports-and-recreational-activities
#18
Lynn Babcock, Cody S Olsen, David M Jaffe, Julie C Leonard
OBJECTIVE: The aim of this study was to ascertain potential factors associated with cervical spine injuries in children injured during sports and recreational activities. METHODS: This is a secondary analysis of a multicenter retrospective case-control study involving children younger than 16 years who presented to emergency departments after blunt trauma and underwent cervical spine radiography. Cases had cervical spine injury from sports or recreational activities (n = 179)...
September 30, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27676720/can-men-with-spinal-cord-injury-have-children
#19
Caroline Voiry, Kathleen Charvier, Frédérique Courtois, Pascal Giraux, Corinne Berthelot-Del Aguila, Gille Rode
OBJECTIVE: Most French people think that disabled people do not have any sexual life in terms of pleasure and reproduction. Or sex contributes to a great part of each individual's well-being and health. In our study, we determined the reproductive sexuality of men with an exclusively traumatic spinal cord injury (SCI) treated at the Henry-Gabrielle Hospital in Saint-Genis-Laval from January 2000 to December 2010, who benefited, or not, from a sexological assessment. MATERIAL/PATIENTS AND METHODS: This is an observational and retrospective study on the number of births in a cohort of 320 men with SCI, aged from 18 to 45 years at the time of their accident and who have an exclusively traumatic SCI without any evolution...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676719/outcomes-of-cryopreserved-sperm-in-case-of-spinal-cord-injury-in-lyon-france
#20
Perrine Séguin, Kathleen Charvier, Frédérique Courtois, Corinne Del Aguila, Bruno Fernandez, Gilles Rode, Jacqueline Lornage, Alain Ruffion, Sandrine Giscard d'Estaing
OBJECTIVE: Sperm cryopreservation can be offered to men with spinal cord injury, as only 10% of spinal cord injured men (SCI) can have a child without assistive reproductive technologies (ART). Very few studies are dedicated to the outcomes of these cryopreservations. Our study aims to analyze the outcomes of these cryopreservation, namely their use or not for an ART, and to evaluate the success rate in case of ART. MATERIAL/PATIENTS AND METHODS: In May 2015, we retrospectively identified all people with stable spinal cord injury sent to the CECOS (Centre d'études de la conservation des œufs et du sperme: Egg, Sperm Embryo banking) by the department of neuroperineology based in the hospital Henry Gabrielle, for the first time between 1st January 2009 and 31st December 2013, to undergo a sperm cryopreservation of spermatozoa...
September 2016: Annals of Physical and Rehabilitation Medicine
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