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JOURNAL ARTICLE
Hannah L Casey, Vrutangkumar V Shah, Daniel Muzyka, James McNames, Mahmoud El-Gohary, Kristen Sowalsky, Delaram Safarpour, Patricia Carlson-Kuhta, Jeremy D Schmahmann, Liana S Rosenthal, Susan Perlman, Christian Rummey, Fay B Horak, Christopher M Gomez
BACKGROUND: Progressive loss of standing balance is a feature of Friedreich's ataxia (FRDA). OBJECTIVES: This study aimed to identify standing balance conditions and digital postural sway measures that best discriminate between FRDA and healthy controls (HC). We assessed test-retest reliability and correlations between sway measures and clinical scores. METHODS: Twenty-eight subjects with FRDA and 20 HC completed six standing conditions: feet apart, feet together, and feet tandem, both with eyes opened (EO) and eyes closed...
March 12, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
#2
JOURNAL ARTICLE
Anna H Ou, Sara B Rosenthal, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Martin Alda, Azmeraw T Amare, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Lena Backlund, Michael Bauer, Bernhard T Baune, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Abesh Kumar Bhattacharjee, Joanna M Biernacka, Pablo Cervantes, Guo-Bo Chen, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Scott R Clark, Francesc Colom, David A Cousins, Cristiana Cruceanu, Piotr M Czerski, Clarissa R Dantas, Alexandre Dayer, Maria Del Zompo, Franziska Degenhardt, J Raymond DePaulo, Bruno Étain, Peter Falkai, Frederike Tabea Fellendorf, Ewa Ferensztajn-Rochowiak, Andreas J Forstner, Louise Frisén, Mark A Frye, Janice M Fullerton, Sébastien Gard, Julie S Garnham, Fernando S Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Oliver Gruber, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Andrea Hofmann, Liping Hou, Stephane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Tadafumi Kato, Sarah Kittel-Schneider, Barbara König, Po-Hsiu Kuo, Ichiro Kusumi, Nina Lackner, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Carlos A López Jaramillo, Glenda MacQueen, Mario Maj, Mirko Manchia, Cynthia Marie-Claire, Lina Martinsson, Manuel Mattheisen, Michael J McCarthy, Susan L McElroy, Francis J McMahon, Philip B Mitchell, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Caroline M Nievergelt, Markus M Nöthen, Tomas Novák, Urban Ösby, Norio Ozaki, Sergi Papiol, Roy H Perlis, Claudia Pisanu, James B Potash, Andrea Pfennig, Daniela Reich-Erkelenz, Andreas Reif, Eva Z Reininghaus, Marcella Rietschel, Guy A Rouleau, Janusz K Rybakowski, Martin Schalling, Peter R Schofield, K Oliver Schubert, Thomas G Schulze, Barbara W Schweizer, Florian Seemüller, Giovanni Severino, Tatyana Shekhtman, Paul D Shilling, Kazutaka Shimoda, Christian Simhandl, Claire M Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Sarah K Tighe, Alfonso Tortorella, Gustavo Turecki, Eduard Vieta, Julia Volkert, Stephanie Witt, Naomi R Wray, Adam Wright, L Trevor Young, Peter P Zandi, John R Kelsoe
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study...
February 23, 2024: Translational Psychiatry
#3
JOURNAL ARTICLE
Niall J Lennon, Leah C Kottyan, Christopher Kachulis, Noura S Abul-Husn, Josh Arias, Gillian Belbin, Jennifer E Below, Sonja I Berndt, Wendy K Chung, James J Cimino, Ellen Wright Clayton, John J Connolly, David R Crosslin, Ozan Dikilitas, Digna R Velez Edwards, QiPing Feng, Marissa Fisher, Robert R Freimuth, Tian Ge, Joseph T Glessner, Adam S Gordon, Candace Patterson, Hakon Hakonarson, Maegan Harden, Margaret Harr, Joel N Hirschhorn, Clive Hoggart, Li Hsu, Marguerite R Irvin, Gail P Jarvik, Elizabeth W Karlson, Atlas Khan, Amit Khera, Krzysztof Kiryluk, Iftikhar Kullo, Katie Larkin, Nita Limdi, Jodell E Linder, Ruth J F Loos, Yuan Luo, Edyta Malolepsza, Teri A Manolio, Lisa J Martin, Li McCarthy, Elizabeth M McNally, James B Meigs, Tesfaye B Mersha, Jonathan D Mosley, Anjene Musick, Bahram Namjou, Nihal Pai, Lorenzo L Pesce, Ulrike Peters, Josh F Peterson, Cynthia A Prows, Megan J Puckelwartz, Heidi L Rehm, Dan M Roden, Elisabeth A Rosenthal, Robb Rowley, Konrad Teodor Sawicki, Daniel J Schaid, Roelof A J Smit, Johanna L Smith, Jordan W Smoller, Minta Thomas, Hemant Tiwari, Diana M Toledo, Nataraja Sarma Vaitinadin, David Veenstra, Theresa L Walunas, Zhe Wang, Wei-Qi Wei, Chunhua Weng, Georgia L Wiesner, Xianyong Yin, Eimear E Kenny
Polygenic risk scores (PRSs) have improved in predictive performance, but several challenges remain to be addressed before PRSs can be implemented in the clinic, including reduced predictive performance of PRSs in diverse populations, and the interpretation and communication of genetic results to both providers and patients. To address these challenges, the National Human Genome Research Institute-funded Electronic Medical Records and Genomics (eMERGE) Network has developed a framework and pipeline for return of a PRS-based genome-informed risk assessment to 25,000 diverse adults and children as part of a clinical study...
February 2024: Nature Medicine
#4
JOURNAL ARTICLE
Pragya Kakani, David M Cutler, Meredith B Rosenthal, Nancy L Keating
IMPORTANCE: Increasing integration across medical services may have important implications for health care quality and spending. One major but poorly understood dimension of integration is between physician organizations and pharmacies for self-administered drugs or in-house pharmacies. OBJECTIVE: To describe trends in the use of in-house pharmacies, associated physician organization characteristics, and associated drug prices. DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional study was conducted from calendar years 2011 to 2019...
February 5, 2024: JAMA Network Open
#5
JOURNAL ARTICLE
Gerard J Kleywegt, Paul D Adams, Sarah J Butcher, Catherine L Lawson, Alexis Rohou, Peter B Rosenthal, Sriram Subramaniam, Maya Topf, Sanja Abbott, Philip R Baldwin, John M Berrisford, Gérard Bricogne, Preeti Choudhary, Tristan I Croll, Radostin Danev, Sai J Ganesan, Timothy Grant, Aleksandras Gutmanas, Richard Henderson, J Bernard Heymann, Juha T Huiskonen, Andrei Istrate, Takayuki Kato, Gabriel C Lander, Shee Mei Lok, Steven J Ludtke, Garib N Murshudov, Ryan Pye, Grigore D Pintilie, Jane S Richardson, Carsten Sachse, Osman Salih, Sjors H W Scheres, Gunnar F Schroeder, Carlos Oscar S Sorzano, Scott M Stagg, Zhe Wang, Rangana Warshamanage, John D Westbrook, Martyn D Winn, Jasmine Y Young, Stephen K Burley, Jeffrey C Hoch, Genji Kurisu, Kyle Morris, Ardan Patwardhan, Sameer Velankar
In January 2020, a workshop was held at EMBL-EBI (Hinxton, UK) to discuss data requirements for the deposition and validation of cryoEM structures, with a focus on single-particle analysis. The meeting was attended by 47 experts in data processing, model building and refinement, validation, and archiving of such structures. This report describes the workshop's motivation and history, the topics discussed, and the resulting consensus recommendations. Some challenges for future methods-development efforts in this area are also highlighted, as is the implementation to date of some of the recommendations...
March 1, 2024: IUCrJ
#6
JOURNAL ARTICLE
Vrutangkumar V Shah, Daniel Muzyka, Adam Jagodinsky, James McNames, Hannah Casey, Mahmoud El-Gohary, Kristen Sowalsky, Delaram Safarpour, Patricia Carlson-Kuhta, Jeremy D Schmahmann, Liana S Rosenthal, Susan Perlman, Fay B Horak, Christopher M Gomez
BACKGROUND: Maintaining balance is crucial for independence and quality of life. Loss of balance is a hallmark of spinocerebellar ataxia (SCA). OBJECTIVE: The aim of this study was to identify which standing balance conditions and digital measures of body sway were most discriminative, reliable, and valid for quantifying balance in SCA. METHODS: Fifty-three people with SCA (13 SCA1, 13 SCA2, 14 SCA3, and 13 SCA6) and Scale for Assessment and Rating of Ataxia (SARA) scores 9...
February 15, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
#7
JOURNAL ARTICLE
Thomas H Ottens, Carsten Hermes, Valerie Page, Mark Oldham, Rakesh Arora, O Joseph Bienvenu, Mark van den Boogaard, Gideon Caplan, John W Devlin, Michaela-Elena Friedrich, Willem A van Gool, James Hanison, Hans-Christian Hansen, Sharon K Inouye, Barbara Kamholz, Katarzyna Kotfis, Matthew B Maas, Alasdair M J MacLullich, Edward R Marcantonio, Alessandro Morandi, Barbara C van Munster, Ursula Müller-Werdan, Alessandra Negro, Karin J Neufeld, Peter Nydahl, Esther S Oh, Pratik Pandharipande, Finn M Radtke, Sylvie De Raedt, Lisa J Rosenthal, Robert Sanders, Claudia D Spies, Emma R L C Vardy, Eelco F Wijdicks, Arjen J C Slooter
Delirium is common in hospitalised patients, and there is currently no specific treatment. Identifying and treating underlying somatic causes of delirium is the first priority once delirium is diagnosed. Several international guidelines provide clinicians with an evidence-based approach to screening, diagnosis and symptomatic treatment. However, current guidelines do not offer a structured approach to identification of underlying causes. A panel of 37 internationally recognised delirium experts from diverse medical backgrounds worked together in a modified Delphi approach via an online platform...
2024: Delirium (Bielef)
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JOURNAL ARTICLE
Joshua B Klatt, Allan K Metz, Devin L Froerer, Joseph Featherall, Jenna R Cheminant, Reece M Rosenthal, Stephen K Aoki
INTRODUCTION: The purpose of this study was to describe proximal femoral deformity after contralateral hip prophylactic fixation of slipped capital femoral epiphysis (SCFE) in patients and the association of relative skeletal immaturity with this deformity. METHODS: A retrospective review of patients presenting with a SCFE was conducted from 2009 to 2015. Inclusion criteria were (1) radiographic evidence of a unilateral SCFE treated with in situ fixation, (2) contralateral prophylactic fixation of an unslipped hip, and (3) at least 3 years of follow-up...
January 23, 2024: Journal of the American Academy of Orthopaedic Surgeons
#9
JOURNAL ARTICLE
Louisa P Selvadurai, Susan L Perlman, Tetsuo Ashizawa, George R Wilmot, Chiadi U Onyike, Liana S Rosenthal, Vikram G Shakkottai, Henry L Paulson, Sub H Subramony, Khalaf O Bushara, Sheng-Han Kuo, Cameron Dietiker, Michael D Geschwind, Alexandra B Nelson, Christopher M Gomez, Puneet Opal, Theresa A Zesiewicz, Trevor Hawkins, Talene A Yacoubian, Peggy C Nopoulos, Sharon J Sha, Peter E Morrison, Karla P Figueroa, Stefan M Pulst, Jeremy D Schmahmann
The Cerebellar Cognitive Affective/Schmahmann Syndrome (CCAS) manifests as impaired executive control, linguistic processing, visual spatial function, and affect regulation. The CCAS has been described in the spinocerebellar ataxias (SCAs), but its prevalence is unknown. We analyzed results of the CCAS/Schmahmann Scale (CCAS-S), developed to detect and quantify CCAS, in two natural history studies of 309 individuals Symptomatic for SCA1, SCA2, SCA3, SCA6, SCA7, or SCA8, 26 individuals Pre-symptomatic for SCA1 or SCA3, and 37 Controls...
January 2, 2024: Cerebellum
#10
JOURNAL ARTICLE
Sina Asaadi, Kaushik Mukherjee, Ahmed M Abou-Zamzam, Liang Ji, Xian Luo-Owen, Maryam B Tabrizi, Richard D Catalano, Joseph J Dubose, Martin G Rosenthal
BACKGROUND: Tranexamic acid (TXA) is associated with lower mortality and transfusion requirements in trauma patients, but its role in thrombotic complications associated with vascular repairs remains unclear. We investigated whether TXA increases the risk of thrombosis-related technical failure (TRTF) in major vascular injuries (MVI). METHODS: The PROspective Observational Vascular Injury Treatment (PROOVIT) registry was queried from 2013 to 2022 for MVI repaired with an open or endovascular intervention...
December 8, 2023: Journal of Trauma and Acute Care Surgery
#11
Gerard J Kleywegt, Paul D Adams, Sarah J Butcher, Cathy Lawson, Alexis Rohou, Peter B Rosenthal, Sriram Subramaniam, Maya Topf, Sanja Abbott, Philip R Baldwin, John M Berrisford, Gérard Bricogne, Preeti Choudhary, Tristan I Croll, Radostin Danev, Sai J Ganesan, Timothy Grant, Aleksandras Gutmanas, Richard Henderson, J Bernard Heymann, Juha T Huiskonen, Andrei Istrate, Takayuki Kato, Gabriel C Lander, Shee-Mei Lok, Steven J Ludtke, Ryan Pye, Grigore D Pintilie, Jane S Richardson, Carsten Sachse, Osman Salih, Sjors H W Scheres, Carlos Oscar S Sorzano, Scott M Stagg, Zhe Wang, Rangana Warshamanage, John D Westbrook, Martyn D Winn, Jasmine Y Young, Stephen K Burley, Jeffrey C Hoch, Genji Kurisu, Kyle Morris, Ardan Patwardhan, Sameer Velankar
In January 2020, a workshop was held at EMBL-EBI (Hinxton, UK) to discuss data requirements for deposition and validation of cryoEM structures, with a focus on single-particle analysis. The meeting was attended by 45 experts in data processing, model building and refinement, validation, and archiving of such structures. This report describes the workshop's motivation and history, the topics discussed, and consensus recommendations resulting from the workshop. Some challenges for future methods-development efforts in this area are also highlighted, as is the implementation to date of some of the recommendations...
November 29, 2023: ArXiv
#12
JOURNAL ARTICLE
Madiha Iqbal, Deepa Jagadeesh, Julio Chavez, Arushi Khurana, Allison Rosenthal, Emily Craver, Narendranath Epperla, Zhuo Li, Iris Isufi, Farrukh T Awan, Bhagirathbhai R Dholaria, Joseph E Maakaron, Jose D Sandoval-Sus, Rahul Mishra, Aditi Saha, Kaitlin Annunzio, Shakthi T Bhaskar, Nuttavut Sumransub, Andrew Fijalka, Stanislav A Ivanov, Yi Lin, Mohamed A Kharfan-Dabaja
Outcomes are poor for patients with relapsed and/or refractory (R/R) large B-cell lymphoma (LBCL) post chimeric antigen receptor T-cell (CAR-T) therapy. Two CD19-directed therapies, tafasitamab- cxix plus lenalidomide (tafa-len) and loncastuximab tesirine (loncaT) are approved in R/R LBCL. The efficacy of these CD19 directed therapies in patients who relapse after CD19 directed CAR-T (CD19-CART) therapy is not well understood. We conducted a multi-center study of patients with R/R LBCL that received either tafa-len or loncaT at any timepoint for R/R disease after CD19-CART therapy...
November 16, 2023: Bone Marrow Transplantation
#13
Elisabeth A Rosenthal, Li Hsu, Minta Thomas, Ulrike Peters, Christopher Kachulis, Karynne Patterson, Gail P Jarvik
BACKGROUND: Colorectal cancer (CRC) is a complex disease with monogenic, polygenic and environmental risk factors. Polygenic risk scores (PRS) are being developed to identify high polygenic risk individuals. Due to differences in genetic background, PRS distributions vary by ancestry, necessitating calibration. METHODS: We compared four calibration methods using the All of Us Research Program Whole Genome Sequence data for a CRC PRS previously developed in participants of European and East Asian ancestry...
January 8, 2024: medRxiv
#14
JOURNAL ARTICLE
S Maroongroge, C I H M Nguyen, A C Moreno, D I Rosenthal, L L Mayo, A S Garden, G B Gunn, J Phan, A Lee, C D Fuller, W H Morrison, M T Spiotto, L E Court, T Netherton
PURPOSE/OBJECTIVE(S): Manual contouring of head and neck lymph node levels is a time-intensive process prone to provider-specific variation. The purpose of this work is to generate a clinical segmentation tool while minimizing the amount of manual effort required by physicians to develop training datasets and review contours. Here we investigate an approach to curate, develop, and clinically validate an auto-contouring model for standard cervical lymph node volumes in the head and neck using a publicly available deep learning architecture...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#15
JOURNAL ARTICLE
R Phillips, J Proudfoot, E Davicioni, D E Spratt, F Y Feng, J Simko, R B Den, A Pollack, S A Rosenthal, O Sartor, C Sweeney, G Attard, S I Patel, W A Hall, J A Efstathiou, A B Shah, K E Hoffman, S Pugh, H M Sandler, P T Tran
PURPOSE/OBJECTIVE(S): Decipher is a prognostic genomic classifier (GC) validated in several prospective NRG Oncology Phase III trials. Herein, we validate the GC in pre-treatment biopsy samples for risk stratification in a cohort of high-risk men treated with definitive radiotherapy and androgen suppression with or without docetaxel chemotherapy. MATERIALS/METHODS: As per a pre-specified and approved NCI analysis plan (Navigator #1061), we obtained available formalin-fixed paraffin-embedded tissue from biopsy specimens from the NRG biobank from patients enrolled on the NRG/RTOG 0521 randomized phase III trial...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#16
JOURNAL ARTICLE
Minta Thomas, Yu-Ru Su, Elisabeth A Rosenthal, Lori C Sakoda, Stephanie L Schmit, Maria N Timofeeva, Zhishan Chen, Ceres Fernandez-Rozadilla, Philip J Law, Neil Murphy, Robert Carreras-Torres, Virginia Diez-Obrero, Franzel J B van Duijnhoven, Shangqing Jiang, Aesun Shin, Alicja Wolk, Amanda I Phipps, Andrea Burnett-Hartman, Andrea Gsur, Andrew T Chan, Ann G Zauber, Anna H Wu, Annika Lindblom, Caroline Y Um, Catherine M Tangen, Chris Gignoux, Christina Newton, Christopher A Haiman, Conghui Qu, D Timothy Bishop, Daniel D Buchanan, David R Crosslin, David V Conti, Dong-Hyun Kim, Elizabeth Hauser, Emily White, Erin Siegel, Fredrick R Schumacher, Gad Rennert, Graham G Giles, Heather Hampel, Hermann Brenner, Isao Oze, Jae Hwan Oh, Jeffrey K Lee, Jennifer L Schneider, Jenny Chang-Claude, Jeongseon Kim, Jeroen R Huyghe, Jiayin Zheng, Jochen Hampe, Joel Greenson, John L Hopper, Julie R Palmer, Kala Visvanathan, Keitaro Matsuo, Koichi Matsuda, Keum Ji Jung, Li Li, Loic Le Marchand, Ludmila Vodickova, Luis Bujanda, Marc J Gunter, Marco Matejcic, Mark A Jenkins, Martha L Slattery, Mauro D'Amato, Meilin Wang, Michael Hoffmeister, Michael O Woods, Michelle Kim, Mingyang Song, Motoki Iwasaki, Mulong Du, Natalia Udaltsova, Norie Sawada, Pavel Vodicka, Peter T Campbell, Polly A Newcomb, Qiuyin Cai, Rachel Pearlman, Rish K Pai, Robert E Schoen, Robert S Steinfelder, Robert W Haile, Rosita Vandenputtelaar, Ross L Prentice, Sébastien Küry, Sergi Castellví-Bel, Shoichiro Tsugane, Sonja I Berndt, Soo Chin Lee, Stefanie Brezina, Stephanie J Weinstein, Stephen J Chanock, Sun Ha Jee, Sun-Seog Kweon, Susan Vadaparampil, Tabitha A Harrison, Taiki Yamaji, Temitope O Keku, Veronika Vymetalkova, Volker Arndt, Wei-Hua Jia, Xiao-Ou Shu, Yi Lin, Yoon-Ok Ahn, Zsofia K Stadler, Bethany Van Guelpen, Cornelia M Ulrich, Elizabeth A Platz, John D Potter, Christopher I Li, Reinier Meester, Victor Moreno, Jane C Figueiredo, Graham Casey, Iris Lansdorp Vogelaar, Malcolm G Dunlop, Stephen B Gruber, Richard B Hayes, Paul D P Pharoah, Richard S Houlston, Gail P Jarvik, Ian P Tomlinson, Wei Zheng, Douglas A Corley, Ulrike Peters, Li Hsu
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls)...
October 2, 2023: Nature Communications
#17
JOURNAL ARTICLE
Anna D Sinaiko, Vilsa E Curto, Elizabeth Bambury, Mark J Soto, Meredith B Rosenthal
OBJECTIVE: To understand variation in enrollment in tiered network health plans (TNPs) and the local provider market characteristics associated with TNP penetration. DATA SOURCES AND STUDY SETTING: We used 2013-2017 Massachusetts three-digit ZIP code level employer-sponsored health insurance enrollment data, data on physician horizontal and vertical affiliations from the Massachusetts Provider Database, state hospital reports in 2013, 2015, and 2017, and the 2013-2017 Massachusetts All-Payer Claims database...
September 5, 2023: Health Services Research
#18
JOURNAL ARTICLE
Utilization, Steering, and Spending in Vertical Relationships Between Physicians and Health Systems.
Anna D Sinaiko, Vilsa E Curto, Katherine Ianni, Mark Soto, Meredith B Rosenthal
IMPORTANCE: Vertical relationships (eg, ownership or affiliations, including joint contracting) between physicians and health systems are increasing in the US. OBJECTIVE: To analyze how vertical relationships between primary care physicians (PCPs) and large health systems are associated with changes in ambulatory and acute care utilization, referral patterns, readmissions, and total medical spending for commercially insured individuals. DESIGN, SETTING, AND PARTICIPANTS: This case-control study with a repeated cross-section, stacked event design analyzed outcomes of patients whose attributed PCP entered a vertical relationship with a large health care system in 2015 or 2017 compared with patients whose attributed PCP was either never or always in a vertical relationship with a large health system from 2013 to 2017 in the state of Massachusetts...
September 1, 2023: JAMA health forum
#19
JOURNAL ARTICLE
Jaron G de Wit, Jasper Vonk, Floris J Voskuil, Sebastiaan A H J de Visscher, Kees-Pieter Schepman, Wouter T R Hooghiemstra, Matthijs D Linssen, Sjoerd G Elias, Gyorgy B Halmos, Boudewijn E C Plaat, Jan J Doff, Eben L Rosenthal, Dominic Robinson, Bert van der Vegt, Wouter B Nagengast, Gooitzen M van Dam, Max J H Witjes
Inadequate surgical margins occur frequently in oral squamous cell carcinoma surgery. Fluorescence molecular imaging (FMI) has been explored for intraoperative margin assessment, but data are limited to phase-I studies. In this single-arm phase-II study (NCT03134846), our primary endpoints were to determine the sensitivity, specificity and positive predictive value of cetuximab-800CW for tumor-positive margins detection. Secondary endpoints were safety, close margin detection rate and intrinsic cetuximab-800CW fluorescence...
August 16, 2023: Nature Communications
#20
JOURNAL ARTICLE
Harshabad Singh, Rachel B Keller, Kevin S Kapner, Julien Dilly, Srivatsan Raghavan, Chen Yuan, Elizabeth F Cohen, Michael Tolstorukov, Elizabeth Andrews, Lauren K Brais, Annacarolina da Silva, Kimberly Perez, Douglas A Rubinson, Rishi Surana, Marios Giannakis, Kimmie Ng, Thomas E Clancy, Matthew B Yurgelun, Benjamin L Schlechter, Jeffrey W Clark, Geoffrey I Shapiro, Michael H Rosenthal, Jason L Hornick, Valentina Nardi, Yvonne Y Li, Hersh Gupta, Andrew D Cherniack, Matthew Meyerson, James M Cleary, Jonathan A Nowak, Brian M Wolpin, Andrew J Aguirre
PURPOSE: Approximately 8-10% of pancreatic ductal adenocarcinomas (PDAC) do not harbor mutations in KRAS. Understanding the unique molecular and clinical features of this subset of pancreatic cancer is important to guide patient stratification for clinical trials of molecularly targeted agents. EXPERIMENTAL DESIGN: We analyzed a single-institution cohort of 795 exocrine pancreatic cancer cases (including 785 PDAC cases) with a targeted multi-gene sequencing panel and identified 73 patients (9...
July 18, 2023: Clinical Cancer Research
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