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Rosenthal, B

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https://www.readbyqxmd.com/read/29765769/synthesis-and-crystallographic-characterization-of-2-2-bis-%C3%AE-5-penta-methyl-cyclo-penta-dien-yl-3-4-bis-tri-methyl-sil-yl-2-zircona-furan-5-one-%C3%AE%C2%BA-o-5-triisobutyl-aluminium
#1
Vladimir V Burlakov, Vyacheslav S Bogdanov, Perdita Arndt, Anke Spannenberg, Uwe Rosenthal, Torsten Beweries, Vladimir B Shur
The crystal structure of the title zwitterionic zirconocene complex containing a furan-one unit, [AlZr(C10 H15 )2 (C4 H9 )3 (C9 H18 O2 Si2 )], is reported. On reacting a zircona-furan-one with two equivalents of HAl( i -Bu)2 , disproportionation of the Lewis acid results in the formation of a triiso-butyl-aluminium fragment, Al( i -Bu)3 , which coordinates to the exocyclic carbonyl O atom of the zircona-furan-one ring. Single-crystal X-ray diffraction reveals that the zircona-furan-one ring remains intact with coordination of the aluminium to the exocyclic O atom...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29757495/a-20-year-and-46-000-specimen-journey-to-paris-reveals-the-influence-of-reporting-systems-and-passive-peer-feedback-on-pathologist-practice-patterns
#2
Christopher J VandenBussche, Derek B Allison, Mohit Gupta, Syed Z Ali, Dorothy L Rosenthal
BACKGROUND: An important goal of The Paris System for Reporting Urinary Cytology (TPS) is to reduce unnecessary atypical diagnoses given to urinary tract cytology (UTC) specimens. Since implementation of TPS at the study institution in 2016, the institutional atypical rate has declined only slightly. The authors speculated that TPS might not have had an immediate impact because several faculty members were involved in TPS committees and because TPS contains elements that already had been integrated into institutional practice...
May 14, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29757439/risk-of-thrombosis-with-anti-phospholipid-syndrome-in-systemic-lupus-erythematosus-treated-with-thrombopoietin-receptor-agonists
#3
Zelie Guitton, Louis Terriou, Jean-Christophe Lega, Raphaele Nove-Josserand, Miguel Hie, Zahir Amoura, James B Bussel, Mohamed Hamidou, Eric Rosenthal, Bertrand Lioger, Dominique Chauveau, Axel Chaminade, Nadine Magy-Bertrand, Marc Michel, Sylvain Audia, Bertrand Godeau, Matthieu Mahevas
Objectives: The use of thrombopoietin-receptor agonists (TPO-RAs) has increased as a second-line therapy in ITP, but the efficacy and safety of such drugs has not been evaluated in SLE-associated ITP. Methods: This was a multicentre retrospective cohort study from 2009 to 2016. Participating centres (n = 11) were secondary- or tertiary-care hospitals belonging to the French national network for adult ITP. Results: We included 18 patients with SLE-ITP treated with TPO-RAs; 10 (55%) had aPL, 5 (27%) showing definite APS...
May 10, 2018: Rheumatology
https://www.readbyqxmd.com/read/29733733/characteristics-of-likely-precision-medicine-initiative-participants-drawn-from-a-large-blood-donor-population
#4
Cinnamon S Bloss, Justin Stoler, Cynthia E Schairer, Sara B Rosenthal, Cynthia Cheung, Holly M Rus, Jessica L Block, Jiue-An Jay Yang, Doug Morton, Helen Bixenman, David Wellis
A goal of the Precision Medicine Initiative All of Us Research Program (AoURP) is recruitment of participants who reflect the diversity of the US. Recruitment from among blood bank donors, which may better reflect the demographic makeup of local communities, is one proposed strategy. We evaluated this strategy by analyzing the results of a survey of San Diego Blood Bank donors conducted in November 2015. Whites were more likely than nonwhites to respond to the survey (7.1 percent versus 3.9 percent). However, race was not a significant predictor of interest in participating in precision medicine research...
May 2018: Health Affairs
https://www.readbyqxmd.com/read/29729067/pathological-antibody-mediated-rejection-in-pediatric-heart-transplant-recipients-immunologic-risk-factors-hemodynamic-significance-and-outcomes
#5
Seth A Hollander, David M Peng, Marcos Mills, Gerald J Berry, Marny Fedrigo, Doff B McElhinney, Christopher S Almond, David N Rosenthal
Biopsy-diagnosed pAMR has been observed in over half of pediatric HT recipients within 6 years of transplantation. We report the incidence and outcomes of pAMR at our center. All endomyocardial biopsies for all HT recipients transplanted between 2010 and 2015 were reviewed and classified using contemporary ISHLT guidelines. Graft dysfunction was defined as a qualitative decrement in systolic function by echocardiogram or an increase of ≥3 mm Hg in atrial filling pressure by direct measurement. Among 96 patients, pAMR2 occurred in 7 (7%) over a median follow-up period of 3...
May 4, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29705166/differences-in-knee-and-hip-adduction-and-hip-muscle-activation-in-runners-with-and-without-iliotibial-band-syndrome
#6
Robert L Baker, Richard B Souza, Mitchell J Rauh, Michael Fredericson, Michael D Rosenthal
BACKGROUND: Iliotibial Band Syndrome has been associated with altered hip and knee kinematics in runners. Prior studies have recommended further research on neuromuscular factors at the hip. The frontal plane hip muscles have been a strong focus in strength comparison, but not for electromyography investigation. OBJECTIVE: To compare hip surface electromyography, and frontal plane hip and knee kinematics, in runners with and without iliotibial band syndrome. DESIGN: Observational cross sectional study, 30 participants were tested for motion capture at the hip and knee and muscle activation in the lateral and posterior hip...
April 26, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29700124/biodistribution-and-radiation-dosimetry-of-124-i-iodo-dpa-713-a-pet-radiotracer-for-macrophage-associated-inflammation
#7
Catherine A Foss, Donika Plyku, Alvaro A Ordonez, Julian Sanchez-Bautista, Hailey B Rosenthal, I L Minn, Martin A Lodge, Martin G Pomper, George Sgouros, Sanjay K Jain
Whole body PET/CT imaging was performed using 124 I-iodo-DPA-713, a radioligand for the 18-kDa translocator protein (TSPO), to determine biodistribution and radiation dosimetry. METHODS: Healthy subjects ages 18-65 years underwent whole body PET/CT imaging at either 4, 24 and 48 hours or 24, 48 and 72 hours after intravenous injection with 124 I-iodo-DPA-713. Time-activity curves were generated and used to calculate organ time-integrated activity coefficients for each subject. The resulting time-integrated activity coefficients provided input data for calculation of organ absorbed doses and effective dose for each subject using OLINDA...
April 26, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29661561/clinically-actionable-hypercholesterolemia-and-hypertriglyceridemia-in-children-with-nonalcoholic-fatty-liver-disease
#8
Kathryn E Harlow, Jonathan A Africa, Alan Wells, Patricia H Belt, Cynthia A Behling, Ajay K Jain, Jean P Molleston, Kimberly P Newton, Philip Rosenthal, Miriam B Vos, Stavra A Xanthakos, Joel E Lavine, Jeffrey B Schwimmer
OBJECTIVE: To determine the percentage of children with nonalcoholic fatty liver disease (NAFLD) in whom intervention for low-density lipoprotein cholesterol or triglycerides was indicated based on National Heart, Lung, and Blood Institute guidelines. STUDY DESIGN: This multicenter, longitudinal cohort study included children with NAFLD enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Nonalcoholic Steatohepatitis Clinical Research Network...
April 13, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29659050/continuous-electroencephalography-predicts-delayed-cerebral-ischemia-after-subarachnoid-hemorrhage-a-prospective-study-of-diagnostic-accuracy
#9
Eric S Rosenthal, Siddharth Biswal, Sahar F Zafar, Kathryn L O'Connor, Sophia Bechek, Apeksha V Shenoy, Emily J Boyle, Mouhsin M Shafi, Emily J Gilmore, Brandon P Foreman, Nicolas Gaspard, Thabele M Leslie-Mazwi, Jonathan Rosand, Daniel B Hoch, Cenk Ayata, Sydney S Cash, Andrew J Cole, Aman B Patel, M Brandon Westover
OBJECTIVE: Delayed cerebral ischemia (DCI) is a common, disabling complication of subarachnoid hemorrhage (SAH). Preventing DCI is a key focus of neurocritical care, but interventions carry risk and cannot be applied indiscriminately. While retrospective studies have identified continuous EEG (cEEG) measures associated with DCI, no study has characterized the accuracy of cEEG with sufficient rigor to justify using it to triage patients to interventions or clinical trials. We therefore prospectively assessed the accuracy of cEEG for predicting DCI, following the Standards for Reporting Diagnostic Accuracy Studies...
April 16, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29656894/deterministic-evolutionary-trajectories-influence-primary-tumor-growth-tracerx-renal
#10
Samra Turajlic, Hang Xu, Kevin Litchfield, Andrew Rowan, Stuart Horswell, Tim Chambers, Tim O'Brien, Jose I Lopez, Thomas B K Watkins, David Nicol, Mark Stares, Ben Challacombe, Steve Hazell, Ashish Chandra, Thomas J Mitchell, Lewis Au, Claudia Eichler-Jonsson, Faiz Jabbar, Aspasia Soultati, Simon Chowdhury, Sarah Rudman, Joanna Lynch, Archana Fernando, Gordon Stamp, Emma Nye, Aengus Stewart, Wei Xing, Jonathan C Smith, Mickael Escudero, Adam Huffman, Nik Matthews, Greg Elgar, Ben Phillimore, Marta Costa, Sharmin Begum, Sophia Ward, Max Salm, Stefan Boeing, Rosalie Fisher, Lavinia Spain, Carolina Navas, Eva Grönroos, Sebastijan Hobor, Sarkhara Sharma, Ismaeel Aurangzeb, Sharanpreet Lall, Alexander Polson, Mary Varia, Catherine Horsfield, Nicos Fotiadis, Lisa Pickering, Roland F Schwarz, Bruno Silva, Javier Herrero, Nick M Luscombe, Mariam Jamal-Hanjani, Rachel Rosenthal, Nicolai J Birkbak, Gareth A Wilson, Orsolya Pipek, Dezso Ribli, Marcin Krzystanek, Istvan Csabai, Zoltan Szallasi, Martin Gore, Nicholas McGranahan, Peter Van Loo, Peter Campbell, James Larkin, Charles Swanton
The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, TRACERx Renal. We observe up to 30 driver events per tumor and show that subclonal diversification is associated with known prognostic parameters. By resolving the patterns of driver event ordering, co-occurrence, and mutual exclusivity at clone level, we show the deterministic nature of clonal evolution...
April 11, 2018: Cell
https://www.readbyqxmd.com/read/29653224/tumor-uptake-of-pegylated-diabodies-balancing-systemic-clearance-and-vascular-transport
#11
Qing Li, Jason B White, Norman C Peterson, Keith W Rickert, Christopher O Lloyd, Kevin L Allen, Kim Rosenthal, Xizhe Gao, Herren Wu, William F Dall'Acqua, M Jack Borrok, Ping Tsui
The accumulation, dissemination and clearance of monoclonal antibody-based therapeutics or imaging reagents targeting tumor associated antigens is governed by several factors including affinity, size, charge, and valency. Tumor targeting antibody fragments have distinct advantages over intact monoclonal antibodies such as enhanced penetration within the tumor and rapid accumulation but are subject to rapid clearance. Polyethylene glycol (PEG)-modified antibody fragments can provide a way to balance tumor penetration and accumulation with improved serum persistence...
April 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29644082/characterisation-of-anifrolumab-a-fully-human-anti-interferon-receptor-antagonist-antibody-for-the-treatment-of-systemic-lupus-erythematosus
#12
Jeffrey M Riggs, Richard N Hanna, Bhargavi Rajan, Kamelia Zerrouki, Jodi L Karnell, Divya Sagar, Inna Vainshtein, Erika Farmer, Kimberly Rosenthal, Chris Morehouse, Melissa de Los Reyes, Kevin Schifferli, Meina Liang, Miguel A Sanjuan, Gary P Sims, Roland Kolbeck
Objective: We investigated the mechanistic and pharmacological properties of anifrolumab, a fully human, effector-null, anti-type I interferon (IFN) alpha receptor 1 (IFNAR1) monoclonal antibody in development for SLE. Methods: IFNAR1 surface expression and internalisation on human monocytes before and after exposure to anifrolumab were assessed using confocal microscopy and flow cytometry. The effects of anifrolumab on type I IFN pathway activation were assessed using signal transducer and activator of transcription 1 (STAT1) phosphorylation, IFN-stimulated response element-luciferase reporter cell assays and type I IFN gene signature induction...
2018: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29643089/physicians-political-preferences-and-the-delivery-of-end-of-life-care-in-the-united-states-retrospective-observational-study
#13
Anupam B Jena, Andrew R Olenski, Dhruv Khullar, Adam Bonica, Howard Rosenthal
OBJECTIVES: To compare the delivery of end of life care given to US Medicare beneficiaries in hospital by internal medicine physicians with Republican versus Democrat political affiliations. DESIGN: Retrospective observational study. SETTING: US Medicare. PARTICIPANTS: Random sample of Medicare beneficiaries, who were admitted to hospital in 2008-12 with a general medical condition, and died in hospital or shortly thereafter...
April 11, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29602992/updated-panel-report-best-practices-for-the-surgical-treatment-of-obesity
#14
Dana A Telem, Daniel B Jones, Philip R Schauer, Stacy A Brethauer, Raul J Rosenthal, David Provost, Stephanie B Jones
BACKGROUND: During the 2004 annual meeting of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), a panel of experts convened to provide updated information on best practices in bariatric surgery. The rapid evolution of endoluminal technologies, surgical indications, and training in bariatric surgery since 2004 has led to new questions and concerns about optimal treatment algorithms, patient selection, and the preparation of our current and future bariatric workforce...
March 30, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29599668/selected-presentations-of-lip-enlargement-clinical-manifestation-and-differentiation
#15
REVIEW
Katarzyna J Błochowiak, Bartłomiej Kamiński, Henryk Witmanowski, Jerzy Sokalski
Lip enlargement may be an important symptom of either systemic or local diseases. On the basis of selected age-matched clinical cases we present the possible causes of lip swelling. We describe the most representative symptoms and recommend treatment of these pathologies. We differentiate lip swelling in Miescher syndrome, monosymptomatic form of Melkersson-Rosenthal syndrome, lip swelling in erythema multiforme and Stevens-Johnson syndrome and lip hemangioma and mucous extravasation cyst. We compare different causes of lip edema and indicate the most helpful diagnostic and treatment methods...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29596265/a-multidisciplinary-discharge-timeout-checklist-improves-patient-education-and-captures-discharge-process-errors
#16
Michael C Gao, Paul B Martin, Julius Motal, Laura F Gingras, Christina Chai, Megan E Maikoff, Alex M Sarkisian, Nadine Rosenthal, Brian M Eiss
OBJECTIVE: To design and implement a discharge timeout checklist, and to assess its effects on patients' understanding as well as the potential impact on preventable medical errors surrounding hospital discharges to home. METHODS: Based on the structure successfully used for surgical procedures and using the Model for Improvement framework, we designed a discharge checklist to review and assess patients' understanding of discharge medications, catheters, home care plans, follow-up, symptoms, and who to call with problems after discharge...
April 2018: Quality Management in Health Care
https://www.readbyqxmd.com/read/29567784/treatment-to-suppression-of-focal-lesions-on-positron-emission-tomography-computed-tomography-is-a-therapeutic-goal-in-newly-diagnosed-multiple-myeloma
#17
Faith E Davies, Adam Rosenthal, Leo Rasche, Nathan M Petty, James E McDonald, James A Ntambi, Doug M Steward, Susan B Panozzo, Frits van Rhee, Maurizio Zangari, Carolina D Schinke, Sharmilan Thanendrarajan, Brian Walker, Niels Weinhold, Bart Barlogie, Antje Hoering, Gareth J Morgan
Fluorine-18 fluorodeoxyglucose positron emission tomography with CT attenuation correction (PET-CT) in myeloma can detect and enumerate focal lesions by the quantitative characterization of metabolic activity. The aim of this study was to determine the prognostic significance of the suppression of PET-CT activity at a number of time points post therapy initiation including day 7, post-induction, post-transplant and at maintenance therapy. As part of the TT4-6 trial series, 596 patients underwent baseline PET-CT and were evaluated serially during their disease course using peak standardized uptake values above background red marrow signal...
March 22, 2018: Haematologica
https://www.readbyqxmd.com/read/29563320/an-ox40-ox40l-interaction-directs-successful-immunity-to-hepatitis-b-virus
#18
Jean Publicover, Anuj Gaggar, Jillian M Jespersen, Ugur Halac, Audra J Johnson, Amanda Goodsell, Lia Avanesyan, Stephen L Nishimura, Meghan Holdorf, Keith G Mansfield, Joyce Bousquet Judge, Arya Koshti, Michael Croft, Adil E Wakil, Philip Rosenthal, Eric Pai, Stewart Cooper, Jody L Baron
Depending on age of acquisition, hepatitis B virus (HBV) can induce a cell-mediated immune response that results in either cure or progressive liver injury. In adult-acquired infection, HBV antigens are usually cleared, whereas in infancy-acquired infection, they persist. Individuals infected during infancy therefore represent the majority of patients chronically infected with HBV (CHB). A therapy that can promote viral antigen clearance in most CHB patients has not been developed and would represent a major health care advance and cost mitigator...
March 21, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29553277/overuse-and-insurance-plan-type-in-a-privately-insured-population
#19
Meredith B Rosenthal, Carrie H Colla, Nancy E Morden, Thomas D Sequist, Alexander J Mainor, Zhonghe Li, Kevin H Nguyen
OBJECTIVES: A substantial portion of healthcare spending is wasted on services that do not directly improve patient health and that cause harm in some cases. Features of health insurance coverage, including enrollment in high-deductible health plans (HDHPs) or health maintenance organizations (HMOs), may provide financial and nonfinancial mechanisms to potentially reduce overuse of low-value healthcare services. STUDY DESIGN: Using 2009 to 2013 administrative data from 3 large commercial insurers, we examined patient characteristics and health insurance plan types associated with overuse of 6 healthcare services identified by the Choosing Wisely campaign...
March 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29530383/high-resolution-magnetization-transfer-mri-in-patients-with-cervical-spondylotic-myelopathy
#20
Linda I Suleiman, Kenneth A Weber, Brett D Rosenthal, Surabhi A Bhatt, Jason W Savage, Wellington K Hsu, Alpesh A Patel, Todd B Parrish
Magnetization transfer (MT) contrast has been established as a marker of myelin integrity, and cervical spondylotic myelopathy is known to cause demyelination. Ten patients with clinical and magnetic resonance imaging (MRI) manifestations of cervical spondylotic myelopathy (CSM) were compared to the MRIs of seven historic healthy controls, using the magnetization transfer ratio (MTR) and Nurick scores as the primary metrics. Transverse slices through the intervertebral discs of the cervical spine were acquired using a gradient echo sequence (MEDIC) with and without an MT saturation pulse on a 3 Tesla Siemens Prisma scanner (TR = 300 ms, TEeff  = 17 ms, flip angle = 30°, in-plane resolution = 0...
May 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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