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Rosenthal, B

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https://www.readbyqxmd.com/read/28210934/adarri-a-novel-method-to-detect-spurious-r-peaks-in-the-electrocardiogram-for-heart-rate-variability-analysis-in-the-intensive-care-unit
#1
Dennis J Rebergen, Sunil B Nagaraj, Eric S Rosenthal, Matt T Bianchi, Michel J A M van Putten, M Brandon Westover
We developed a simple and fully automated method for detecting artifacts in the R-R interval (RRI) time series of the ECG that is tailored to the intensive care unit (ICU) setting. From ECG recordings of 50 adult ICU-subjects we selected 60 epochs with valid R-peak detections and 60 epochs containing artifacts leading to missed or false positive R-peak detections. Next, we calculated the absolute value of the difference between two adjacent RRIs (adRRI), and obtained the empirical probability distributions of adRRI values for valid R-peaks and artifacts...
February 16, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28184036/redox-preconditioning-deep-cratonic-lithosphere-for-kimberlite-genesis-evidence-from-the-central-slave-craton
#2
G M Yaxley, A J Berry, A Rosenthal, A B Woodland, D Paterson
We present the first oxygen fugacity (fO2) profile through the cratonic lithospheric mantle under the Panda kimberlite (Ekati Diamond Mine) in the Lac de Gras kimberlite field, central Slave Craton, northern Canada. Combining this data with new and existing data from garnet peridotite xenoliths from an almost coeval kimberlite (A154-N) at the nearby Diavik Diamond Mine demonstrates that the oxygen fugacity of the Slave cratonic mantle varies by several orders of magnitude as a function of depth and over short lateral distances...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28172700/p063-hdac-as-versatile-regulators-of-the-intestinal-epithelial-barrier-in-inflammatory-bowel-disease
#3
M Friedrich, J Ganther, T Breiderhoff, R Rosenthal, R Glauben, B Siegmund
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28169971/health-related-quality-of-life-in-pediatric-patients-with-chronic-hepatitis-b-living-in-the-united-states-and-canada
#4
Sarah Jane Schwarzenberg, Simon C Ling, Yona Keich Cloonan, Hsing-Hua S Lin, Donna M Evon, Karen F Murray, Norberto Rodriguez-Baez, Philip Rosenthal, Jeffrey Teckman, Kathleen B Schwarz
OBJECTIVES: To determine if selected socio-demographic and HBV-specific clinical factors are associated with health-related quality of life (HRQoL) among pediatric patients chronically infected with hepatitis B virus (HBV). METHODS: Children with chronic HBV enrolled in the Hepatitis B Research Network completed the Child Health Questionnaire (CHQ) at study entry. Caregivers of children 5- < 10 years completed the parent-reported PF50; youth 10- < 18 years completed the child-reported CF87...
February 4, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28157711/the-repurposed-anthelmintic-mebendazole-in-combination-with-trametinib-suppresses-refractory-nrasq61k-melanoma
#5
Cynthia M Simbulan-Rosenthal, Sivanesan Dakshanamurthy, Anirudh Gaur, You-Shin Chen, Hong-Bin Fang, Maryam Abdussamad, Hengbo Zhou, John Zapas, Valerie Calvert, Emanuel F Petricoin, Michael B Atkins, Stephen W Byers, Dean S Rosenthal
Structure-based drug repositioning in addition to random chemical screening is now a viable route to rapid drug development. Proteochemometric computational methods coupled with kinase assays showed that mebendazole (MBZ) binds and inhibits kinases important in cancer, especially both BRAFWT and BRAFV600E. We find that MBZ synergizes with the MEK inhibitor trametinib to inhibit growth of BRAFWT-NRASQ61K melanoma cells in culture and in xenografts, and markedly decreased MEK and ERK phosphorylation. Reverse Phase Protein Array (RPPA) and immunoblot analyses show that both trametinib and MBZ inhibit the MAPK pathway, and cluster analysis revealed a protein cluster showing strong MBZ+trametinib - inhibited phosphorylation of MEK and ERK within 10 minutes, and its direct and indirect downstream targets related to stress response and translation, including ElK1 and RSKs within 30 minutes...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28155079/fluorescence-imaging-for-cancer-screening-and-surveillance
#6
K E Tipirneni, E L Rosenthal, L S Moore, A D Haskins, N Udayakumar, A H Jani, W R Carroll, A B Morlandt, M Bogyo, J Rao, Jason M Warram
The advent of fluorescence imaging (FI) for cancer cell detection in the field of oncology is promising for both cancer screening and surgical resection. Particularly, FI in cancer screening and surveillance is actively being evaluated in many new clinical trials with over 30 listed on Clinical Trials.gov . While surgical resection forms the foundation of many oncologic treatments, early detection is the cornerstone for improving outcomes and reducing cancer-related morbidity and mortality. The applications of FI are twofold as it can be applied to high-risk patients in addition to those undergoing active surveillance...
February 2, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28131216/monitoring-cd27-memory-b-cells-in-neuromyelitis-optica-spectrum-disorders-patients-treated-with-rituximab-results-from-a-bicentric-study
#7
M Cohen, G Romero, J Bas, M Ticchioni, M Rosenthal, R Lacroix, C Brunet, A Rico, J Pelletier, B Audoin, C Lebrun
BACKGROUND: Rituximab (RTX) is increasingly used in the treatment of neuromyelitis optica spectrum disorder (NMO-SD). Administration regimen is not consensual as there is no reliable biomarker of RTX efficacy. In most cases, after induction, RTX is administered systematically every 6months. OBJECTIVE: To assess efficacy and safety of a maintenance regimen based on CD19+ CD27+ memory B-cell (mBc) detection. METHODS: We conducted a study in two French centers, including patients with NMO-SD who received an induction therapy with RTX...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28126300/effect-of-long-term-hormonal-therapy-vs-short-term-hormonal-therapy-a-secondary-analysis-of-intermediate-risk-prostate-cancer-patients-treated-on-nrg-oncology-rtog-9202
#8
Amin J Mirhadi, Qiang Zhang, Gerald E Hanks, Herbert Lepor, David J Grignon, Christopher A Peters, Seth A Rosenthal, Kenneth Zeitzer, John S Radwan, Colleen Lawton, Matthew B Parliament, Robert S Reznik, Howard M Sandler
PURPOSE: NRG Oncology RTOG 9202 was a randomized trial testing long-term adjuvant androgen deprivation (LTAD) versus initial androgen deprivation only (STAD) with external beam radiation therapy (RT) in mostly high-risk and some intermediate-risk prostate cancer patients. RTOG 9408 found an overall survival (OS) advantage in patients with cT1b-T2b disease and prostate-specific antigen (PSA) <20 ng/mL, with benefit observed mostly among intermediate-risk patients. It was still unknown whether intermediate-risk patients would experience an additional survival benefit with LTAD; thus, we performed a secondary analysis to explore whether LTAD had any incremental benefit beyond STAD among the intermediate-risk subset of RTOG 9202...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28119383/impact-of-heart-transplantation-on-the-functional-status-of-u-s-children-with-end-stage-heart-failure-analysis-of-data-from-the-organ-procurement-and-transplantation-network
#9
David Peng, Yulin Zhang, David N Rosenthal, Michal Palmon, Sharon Chen, Beth D Kaufman, Katsuhide Maeda, Seth Hollander, Nancy McDonald, Leslie B Smoot, Daniel Bernstein, Christopher S Almond
BACKGROUND: -There are limited data describing the functional status (FS) of children after heart transplant (HT). We sought to describe the FS of children surviving at least one year after HT, to evaluate the impact of HT on FS, and to identify factors associated with abnormal FS post-HT. METHODS: -Organ Procurement and Transplantation Network data were used to identify all US children age <21 years surviving ≥1 year post-HT from 2005-2014 with a functional status score (FSS) available at three time points (listing, transplant, ≥1 year post-HT)...
January 24, 2017: Circulation
https://www.readbyqxmd.com/read/28118534/disease-associated-anti-citrullinated-protein-memory-b-cells-in-rheumatoid-arthritis-persist-in-clinical-remission
#10
Adam J Pelzek, Caroline Grönwall, Pamela Rosenthal, Jeffrey D Greenberg, Mandy McGeachy, Larry Moreland, William F C Rigby, Gregg J Silverman
OBJECTIVE: In RA, autoreactive B cells are pathogenic drivers and sources of anti-citrullinated protein antibodies (ACPA) that serve as a diagnostic biomarker and predictor of worse long-term prognosis. Yet the immunobiologic significance of persistent ACPA production at a cellular level is poorly understood. METHODS: In a cross-sectional study of RA patients, we investigated for the presence of continued defects in immune homeostasis as a function of disease activity...
January 24, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28094261/beyond-the-margins-real-time-detection-of-cancer-using-targeted-fluorophores
#11
REVIEW
Ray R Zhang, Alexandra B Schroeder, Joseph J Grudzinski, Eben L Rosenthal, Jason M Warram, Anatoly N Pinchuk, Kevin W Eliceiri, John S Kuo, Jamey P Weichert
Over the past two decades, synergistic innovations in imaging technology have resulted in a revolution in which a range of biomedical applications are now benefiting from fluorescence imaging. Specifically, advances in fluorophore chemistry and imaging hardware, and the identification of targetable biomarkers have now positioned intraoperative fluorescence as a highly specific real-time detection modality for surgeons in oncology. In particular, the deeper tissue penetration and limited autofluorescence of near-infrared (NIR) fluorescence imaging improves the translational potential of this modality over visible-light fluorescence imaging...
January 17, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28092681/genomic-analysis-of-globally-diverse-mycobacterium-tuberculosis-strains-provides-insights-into-the-emergence-and-spread-of-multidrug-resistance
#12
Abigail L Manson, Keira A Cohen, Thomas Abeel, Christopher A Desjardins, Derek T Armstrong, Clifton E Barry, Jeannette Brand, Sinéad B Chapman, Sang-Nae Cho, Andrei Gabrielian, James Gomez, Andreea M Jodals, Moses Joloba, Pontus Jureen, Jong Seok Lee, Lesibana Malinga, Mamoudou Maiga, Dale Nordenberg, Ecaterina Noroc, Elena Romancenco, Alex Salazar, Willy Ssengooba, A A Velayati, Kathryn Winglee, Aksana Zalutskaya, Laura E Via, Gail H Cassell, Susan E Dorman, Jerrold Ellner, Parissa Farnia, James E Galagan, Alex Rosenthal, Valeriu Crudu, Daniela Homorodean, Po-Ren Hsueh, Sujatha Narayanan, Alexander S Pym, Alena Skrahina, Soumya Swaminathan, Martie Van der Walt, David Alland, William R Bishai, Ted Cohen, Sven Hoffner, Bruce W Birren, Ashlee M Earl
Multidrug-resistant tuberculosis (MDR-TB), caused by drug-resistant strains of Mycobacterium tuberculosis, is an increasingly serious problem worldwide. Here we examined a data set of whole-genome sequences from 5,310 M. tuberculosis isolates from five continents. Despite the great diversity of these isolates with respect to geographical point of isolation, genetic background and drug resistance, the patterns for the emergence of drug resistance were conserved globally. We have identified harbinger mutations that often precede multidrug resistance...
January 16, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28087684/the-effect-of-price-information-on-the-ordering-of-images-and-procedures
#13
Alyna T Chien, Smitha Ganeshan, Mark A Schuster, Lisa Soleymani Lehmann, Laura A Hatfield, Kate E Koplan, Carter R Petty, Anna D Sinaiko, Thomas D Sequist, Meredith B Rosenthal
BACKGROUND AND OBJECTIVES: Ordering rates for imaging studies and procedures may change if clinicians are shown the prices of those tests while they are ordering. We studied the effect of 2 forms of paid price information, single median price and paired internal/external median prices, on how often pediatric-focused and adult-oriented clinicians (most frequently general pediatricians and adult specialists caring for pediatric-aged patients, respectively) order imaging studies and procedures for 0- to 21-year-olds...
January 13, 2017: Pediatrics
https://www.readbyqxmd.com/read/28077228/levers-for-addressing-medical-underuse-and-overuse-achieving-high-value-health-care
#14
REVIEW
Adam G Elshaug, Meredith B Rosenthal, John N Lavis, Shannon Brownlee, Harald Schmidt, Somil Nagpal, Peter Littlejohns, Divya Srivastava, Sean Tunis, Vikas Saini
The preceding papers in this Series have outlined how underuse and overuse of health-care services occur within a complex system of health-care production, with a multiplicity of causes. Because poor care is ubiquitous and has considerable consequences for the health and wellbeing of billions of people around the world, remedying this problem is a morally and politically urgent task. Universal health coverage is a key step towards achieving the right care. Therefore, full consideration of potential levers of change must include an upstream perspective-ie, an understanding of the system-level factors that drive overuse and underuse, as well as the various incentives at work during a clinical encounter...
January 6, 2017: Lancet
https://www.readbyqxmd.com/read/28065519/enhancing-pediatric-trainees-and-students-knowledge-in-providing-care-to-transgender-youth
#15
Stanley R Vance, Madeline B Deutsch, Stephen M Rosenthal, Sara M Buckelew
PURPOSE: To enhance pediatric trainees' and students' knowledge of the psychosocial and medical issues facing transgender youth through a comprehensive curriculum. METHODS: During the 2015-2016 academic year, we administered a transgender youth curriculum to fourth-year medical students, pediatric interns, psychiatry interns, and nurse practitioner students on their 1-month adolescent and young adult medicine rotation. The curriculum included six interactive, online modules and an observational experience in a multidisciplinary pediatric gender clinic...
January 5, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28039650/is-bariatric-surgery-safe-in-the-elderly-population
#16
Federico Perez Quirante, Lisandro Montorfano, Rajmohan Rammohan, Nisha Dhanabalsamy, Aaron Lee, Samuel Szomstein, Emanuele Lo Menzo, Raul J Rosenthal
BACKGROUND: Bariatric surgery has proven to be the most effective treatment for morbid obesity in all age groups and is considered superior to medical treatment. The aim of our study was to report the outcomes of bariatric surgery in patients over 65 years of age at our institution. METHODS: A retrospective review of a prospectively collected database was conducted of all patients > 65 years who underwent a bariatric procedure between 2005 and 2015 at our institution...
December 30, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/28039209/everolimus-eluting-stents-stabilize-plaque-inflammation-in-vivo-assessment-by-intravascular-fluorescence-molecular-imaging
#17
Marcella A Calfon Press, Georgios Mallas, Amir Rosenthal, Tetsuya Hara, Adam Mauskapf, R Nika Nudelman, Alexander Sheehy, Igor V Polyakov, Frank Kolodgie, Renu Virmani, J Luis Guerrero, Vasilis Ntziachristos, Farouc A Jaffer
AIMS: Inflammation drives atherosclerosis complications and is a promising therapeutic target for plaque stabilization. At present, it is unknown whether local stenting approaches can stabilize plaque inflammation in vivo. Here, we investigate whether everolimus-eluting stents (EES) can locally suppress plaque inflammatory protease activity in vivo using intravascular near-infrared fluorescence (NIRF) molecular imaging. METHODS AND RESULTS: Balloon-injured, hyperlipidaemic rabbits with atherosclerosis received non-overlapping EES and bare metal stents (BMS) placement into the infrarenal aorta (n = 7 EES, n = 7 BMS, 3...
December 29, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28009280/three-dimensional-architecture-of-the-human-brca1-a-histone-deubiquitinase-core-complex
#18
Otto J P Kyrieleis, Pauline B McIntosh, Sarah R Webb, Lesley J Calder, Janette Lloyd, Nisha A Patel, Stephen R Martin, Carol V Robinson, Peter B Rosenthal, Stephen J Smerdon
BRCA1 is a tumor suppressor found to be mutated in hereditary breast and ovarian cancer and plays key roles in the maintenance of genomic stability by homologous recombination repair. It is recruited to damaged chromatin as a component of the BRCA1-A deubiquitinase, which cleaves K63-linked ubiquitin chains attached to histone H2A and H2AX. BRCA1-A contributes to checkpoint regulation, repair pathway choice, and HR repair efficiency through molecular mechanisms that remain largely obscure. The structure of an active core complex comprising two Abraxas/BRCC36/BRCC45/MERIT40 tetramers determined by negative-stain electron microscopy (EM) reveals a distorted V-shape architecture in which a dimer of Abraxas/BRCC36 heterodimers sits at the base, with BRCC45/Merit40 pairs occupying each arm...
December 20, 2016: Cell Reports
https://www.readbyqxmd.com/read/28006086/recurrent-oral-cavity-cancer-patterns-of-failure-after-salvage-multimodality-therapy
#19
Sean R Quinlan-Davidson, William H Morrison, Jeffrey N Myers, Gary B Gunn, William N William, Beth M Beadle, Heath D Skinner, Ann M Gillenwater, Steven J Frank, Jack Phan, Faye M Johnson, Clifton D Fuller, Mark E Zafereo, David I Rosenthal, Adam S Garden
BACKGROUND: We focused on a cohort of radiation naïve patients who had recurrent oral cavity cancer (recurrent OCC) to assess their outcomes with salvage multimodal therapy. METHODS: A retrospective single institutional study was performed of patients with recurrent OCC. Disease recurrence and survival outcomes were assessed. RESULTS: Seventy-eight patients were analyzed. All patients had salvage surgery and intensity-modulated radiotherapy (IMRT) and 74% had chemotherapy...
December 22, 2016: Head & Neck
https://www.readbyqxmd.com/read/27984233/dermatofibrosarcoma-protuberans-like-tumor-with-col1a1-copy-number-gain-in-the-absence-of-t-17-22
#20
Jad Saab, Ian M Rosenthal, Lu Wang, Klaus J Busam, Kishwer S Nehal, Mark A Dickson, Meera R Hameed, Travis J Hollmann
A 57-year-old woman presented with a 3-year history of a progressive firm plaque on the right cheek. Skin biopsies revealed a bland, storiform, spindle-cell proliferation involving the deep dermis and subcutaneous fat. By immunohistochemistry, the tumor cells were diffusely positive for CD34 and caldesmon with multifocal reactivity for epithelial membrane antigen and focal, weak staining for smooth muscle actin. Retinoblastoma protein expression was not detectable in tumor cells by immunohistochemistry. An interphase fluorescence in situ hybridization analysis for platelet-derived growth factor B (PDGFB) gene rearrangement was negative...
December 14, 2016: American Journal of Dermatopathology
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