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https://www.readbyqxmd.com/read/29458153/eus-guided-transluminal-interventions
#1
Uzma D Siddiqui, Michael J Levy
The role of endoscopic ultrasound (EUS) has transitioned from a diagnostic to a therapeutic one over the past 40 years. With the advent of curvilinear array echoendoscopes in the 1990's with an accessory channel, multiple tools and devices have been developed and utilized for a variety of transluminal interventions. EUS provides a viable option and is becoming the procedure of choice for many interventions including bile and pancreatic duct drainage, guiding angiotherapy, pancreatic fluid collection management, gallbladder drainage, and creating a gastrojejunostomy...
February 16, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29456588/a-survey-of-caregiver-burden-in-those-providing-informal-care-for-patients-with-schizophrenia-or-bipolar-disorder-with-agitation-results-from-a-european-study
#2
Sophee Blanthorn-Hazell, Alfredo Gracia, Jenna Roberts, Anca Boldeanu, Davneet Judge
Background: Agitation is a common feature of bipolar disorder and schizophrenia. Previous research indicates that specific symptoms impact caregiver burden in these conditions, but the impact of agitation on caregiver experience is poorly understood. The aim of this study was to characterise caregiver burden in providers of informal care for patients with bipolar disorder and schizophrenia who experience agitation. Methods: In total, 297 matched patient and caregiver surveys were collected across the UK, Germany and Spain between October 2016 and January 2017...
2018: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29456543/no-interactions-of-stacked-bt-maize-with-the-non-target-aphid-rhopalosiphum-padi-and-the-spider-mite-tetranychus-urticae
#3
Yinghua Shu, Jörg Romeis, Michael Meissle
In the agroecosystem, genetically engineered plants producing insecticidal Cry proteins from Bacillus thuringiensis (Bt) interact with non-target herbivores and other elements of the food web. Stacked Bt crops expose herbivores to multiple Cry proteins simultaneously. In this study, the direct interactions between SmartStax® Bt maize producing six different Cry proteins and two herbivores with different feeding modes were investigated. Feeding on leaves of Bt maize had no effects on development time, fecundity, or longevity of the aphid Rhopalosiphum padi (Hemiptera: Aphididae), and no effects on the egg hatching time, development time, sex ratio, fecundity, and survival of the spider mite Tetranychus urticae (Acari: Tetranychidae)...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29455640/ccl2-ccl5-secreted-by-the-stroma-induce-il-6-pyk2-dependent-chemoresistance-in-ovarian-cancer
#4
Jennifer Pasquier, Marie Gosset, Caroline Geyl, Jessica Hoarau-Véchot, Audrey Chevrot, Marc Pocard, Massoud Mirshahi, Raphael Lis, Arash Rafii, Cyril Touboul
BACKGROUND: Minimal residual disease is the main issue of advanced ovarian cancer treatment. According to the literature and previous results, we hypothesized that Mesenchymal Stromal Cells (MSC) could support this minimal residual disease by protecting ovarian cancer cells (OCC) from chemotherapy. In vitro study confirmed that MSC could induce OCC chemoresistance without contact using transwell setting. Further experiments showed that this induced chemoresistance was dependent on IL-6 OCC stimulation...
February 19, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29454900/immunohistochemical-investigation-of-predictors-of-response-or-agressivity-of-bowen-disease-after-photodynamic-therapy
#5
M Fernández-Guarino, M L González Morales, Israel Bernal, A I Sánchez Adrada, Sandra Pierri Ugia, J Barrio Garde
BACKGROUND: Photodynamic therapy (PDT) is a good option for the treatment of Bowen's disease (BD) but, BD occasionally develops into a squamous cell carcinoma (SCC) after PDT. OBJECTIVE: Find predictors of aggressiveness of BD after PDT METHODS: Two biopsies of patients with BD treated with PDT with progression to SCC within three months were selected for immunohistochemical (IHC) studies. Conventional PDT was applied. IHC analysis was performed together with hematoxylin-eosin in the biopsies prior to and after treatment with PDT...
February 15, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29454849/escmid-study-group-for-infections-in-compromised-hosts-esgich-consensus-document-on-the-safety-of-targeted-and-biological-therapies-an-infectious-diseases-perspective-intracellular-signaling-pathways-tyrosine-kinase-and-mtor-inhibitors
#6
REVIEW
Mark Reinwald, Jose T Silva, Nicolas J Mueller, Jesús Fortún, Christian Garzoni, Johan W de Fijter, Mario Fernández-Ruiz, Paolo Grossi, Jose María Aguado
BACKGROUND: The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies. AIMS: To review, from an Infectious Diseases perspective, the safety profile of therapies targeting different intracellular signaling pathways and to suggest preventive recommendations. SOURCES: Computer-based MEDLINE searches with MeSH terms pertaining to each agent or therapeutic family...
February 15, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29454504/the-radiobiology-of-proton-therapy-challenges-and-opportunities-around-relative-biological-effectiveness
#7
B Jones, S J McMahon, K M Prise
With the current UK expansion of proton therapy there is a great opportunity for clinical oncologists to develop a translational interest in the associated scientific base and clinical results. In particular, the underpinning controversy regarding the conversion of photon dose to proton dose by the relative biological effectiveness (RBE) must be understood, including its important implications. At the present time, the proton prescribed dose includes an RBE of 1.1 regardless of tissue, tumour and dose fractionation...
February 15, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29453934/distinct-domains-of-the-avrpm3-a2-f2-avirulence-protein-from-wheat-powdery-mildew-are-involved-in-immune-receptor-recognition-and-putative-effector-function
#8
Kaitlin Elyse McNally, Fabrizio Menardo, Linda Lüthi, Coraline Rosalie Praz, Marion Claudia Müller, Lukas Kunz, Roi Ben-David, Kottakota Chandrasekhar, Amos Dinoor, Christina Cowger, Emily Meyers, Mingfeng Xue, Fangsong Zeng, Shuangjun Gong, Dazhao Yu, Salim Bourras, Beat Keller
Recognition of the AVRPM3 A2/F2 avirulence protein from powdery mildew by the wheat PM3A/F immune receptor induces a hypersensitive response after co-expression in Nicotiana benthamiana. The molecular determinants of this interaction and how they shape natural AvrPm3 a2/f2 allelic diversity are unknown. We sequenced the AvrPm3 a2/f2 gene in a worldwide collection of 272 mildew isolates. Using the natural polymorphisms of AvrPm3 a2/f2 as well as sequence information from related gene family members, we tested 85 single-residue-altered AVRPM3 A2/F2 variants with PM3A, PM3F and PM3F L 456P/Y458H (modified for improved signaling) in Nicotiana benthamiana for effects on recognition...
February 17, 2018: New Phytologist
https://www.readbyqxmd.com/read/29453295/socioeconomic-religious-spiritual-and-health-factors-associated-with-symptoms-of-common-mental-disorders-a-cross-sectional-secondary-analysis-of-data-from-bhutan-s-gross-national-happiness-study-2015
#9
Gyambo Sithey, Mu Li, Li Ming Wen, Patrick J Kelly, Kelly Clarke
OBJECTIVE: Common mental disorders (CMDs) are a major cause of the global burden of disease. Bhutan was the first country in the world to focus on happiness as a state policy; however, little is known about the prevalence and risk factors of CMDs in this setting. We aim to identify socioeconomic, religious, spiritual and health factors associated with symptoms of CMDs. DESIGN AND SETTING: We used data from Bhutan's 2015 Gross National Happiness (GNH) Survey, a multistage, cross-sectional nationwide household survey...
February 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29453201/hypercalcemia-associated-with-cosmetic-injections-a-systematic-review
#10
Niranjan Tachamo, Anthony Donato, Bidhya Timilsina, Salik Nazir, Saroj Lohani, Rashmi Dhital, Sijan Basnet
Cosmetic injections with silicone and polymethylmethacrylate are not FDA-approved for augmentation of body parts such as breast, buttock or legs, but they have been widely used for decades. Cosmetic injections can cause foreign body granulomas and occasionally severe and life-threatening hypercalcemia. We aimed to systematically analyze the published literature on cosmetic injection-associated hypercalcemia. Methods We searched relevant articles on hypercalcemia associated with various cosmetic injections and extracted relevant data on demographics, cosmetic injections used, severity of hypercalcemia, management and outcomes...
February 16, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29452931/identification-of-novel-uncertainty-factors-and-thresholds-of-toxicological-concern-for-health-hazard-and-risk-assessment-application-to-cleaning-product-ingredients
#11
REVIEW
Zhen Wang, W Casan Scott, E Spencer Williams, Michael Ciarlo, Paul C DeLeo, Bryan W Brooks
Uncertainty factors (UFs) are commonly used during hazard and risk assessments to address uncertainties, including extrapolations among mammals and experimental durations. In risk assessment, default values are routinely used for interspecies extrapolation and interindividual variability. Whether default UFs are sufficient for various chemical uses or specific chemical classes remains understudied, particularly for ingredients in cleaning products. Therefore, we examined publicly available acute median lethal dose (LD50), and reproductive and developmental no-observed-adverse-effect level (NOAEL) and lowest-observed-adverse-effect level (LOAEL) values for the rat model (oral)...
February 13, 2018: Environment International
https://www.readbyqxmd.com/read/29452365/indigenous-medicine-and-biomedical-health-care-in-fragile-settings-insights-from-burundi
#12
Jean-Benoît Falisse, Serena Masino, Raymond Ngenzebuhoro
This study contributes to the health policy debate on medical systems integration by describing and analysing the interactions between health-care users, indigenous healers, and the biomedical public health system, in the so far rarely documented case of post-conflict Burundi. We adopt a mixed-methods approach combining (1) data from an existing survey on access to health-care, with 6,690 individuals, and (2) original interviews and focus groups conducted in 2014 with 121 respondents, including indigenous healers, biomedical staff, and health-care users...
February 14, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29452069/idiopathic-isolated-unilateral-hypoglossal-nerve-palsy-a-report-of-2-cases-and-review-of-the-literature
#13
Akio Shibata, Masashi Kimura, Kenichiro Ishiabashi, Masahiro Umemura
Hypoglossal nerve palsy (HNP) is a common finding in neurologic diseases when associated with other cranial nerve palsies or further pathology and exhibits characteristic clinical manifestations, including unilateral atrophy of the musculature of the tongue. It occasionally appears as the initial or solitary sign of an intracranial or extracranial space-occupying lesion, head or neck injury, or vascular abnormality of the internal carotid artery. There are few cases of idiopathic isolated unilateral HNP, which should be diagnosed through exclusion...
February 2, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29451938/the-management-of-cerebrospinal-fluid-leak-after-anterior-cervical-decompression-surgery
#14
Jiliang Zhai, Ripul R Panchal, Ye Tian, Shujie Wang, Lijuan Zhao
Cerebrospinal fluid (CSF) leak is a rare but potentially troublesome and occasionally catastrophic complication after anterior cervical decompression surgery. There is limited literature describing this complication, and the management of CSF leak varies. The aim of this study was to retrospectively review the treatment of cases with CSF leak and develop a management algorithm. A series of 14 patients with CSF leak from January 2011 to May 2016 were included in this study. Their characteristics, management of CSF leak, and outcomes were documented...
February 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29451304/distinct-methylation-profile-of-mucinous-ovarian-carcinoma-reveals-susceptibility-to-proteasome-inhibitors
#15
Phui-Ly Liew, Rui-Lan Huang, Yu-Chun Weng, Chia-Lang Fang, Tim Hui-Ming Huang, Hung-Cheng Lai
Mucinous type of epithelial ovarian cancer (MuOC) is a unique subtype with a poor survival outcome in recurrent and advanced stages. The role of type-specific epigenomics and its clinical significance remain uncertain. We analyzed the methylomic profiles of six benign mucinous adenomas, 24 MuOCs, 103 serous type of epithelial ovarian cancers (SeOCs), and 337 nonepithelial ovarian cancers. MuOC and SeOC exhibited distinct DNA methylation profiles comprising 101 genes, 81 of which exhibited low methylation in MuOC and were associated with the response to glucocorticoid, ATP hydrolysis-coupled proton transport, proteolysis involved in the cellular protein catabolic process, and ion transmembrane transport...
February 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29450779/effects-of-growth-agents-and-mercury-on-several-herbs
#16
Zhongchuang Liu, Li-Ao Wang, Shimin Ding, Yuehan Li
The paper discussed the effects of growth agents and mercury on the growth of four herb species subjected to a pot experiment: Aloe vera, Setcreasea purpurea, Chlorophytum comosum, and Oxalis corniculata. We determined the height and biomass production of selected plants treated with different growth agents and different concentrations of mercury solutions. We evaluated the relative growth rate (RGR) of the experimental plants. The aim of the study was to explore potential novel solutions to the shortcoming of the low speed of phytoremediation...
February 15, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29450699/consolidation-tumor-ratio-on-chest-computed-tomography-as-predictor-of-postoperative-nodal-upstaging-in-clinical-t1n0-lung-cancer
#17
Youngkyu Moon, Jae Kil Park, Kyo Young Lee, Min Namkoong, Seha Ahn
BACKGROUND: In clinical T1N0 peripheral lung cancers, lymph node upstaging is occasionally encountered postoperatively. However, nodal upstaging is rare in lung cancers presenting as ground-glass opacities. The aim of this study was to determine if lymph node upstaging could be reliably extrapolated from parameters such the consolidation/tumor ratio of chest computed tomography. METHODS: We conducted a retrospective study of 486 patients treated for peripheral clinical T1N0 non-small cell lung cancer, each undergoing lobectomy with mediastinal lymph node dissection...
February 15, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29449842/pan-influenza-a-protection-by-prime-boost-vaccination-with-cold-adapted-live-attenuated-influenza-vaccine-in-a-mouse-model
#18
Yo Han Jang, Joo Young Kim, Young Ho Byun, Ahyun Son, Jeong-Yoon Lee, Yoon Jae Lee, Jun Chang, Baik Lin Seong
Influenza virus infections continually pose a major public health threat with seasonal epidemics and sporadic pandemics worldwide. While currently licensed influenza vaccines provide only strain-specific protection, antigenic drift and shift occasionally render the viruses resistant to the host immune responses, which highlight the need for a vaccine that provides broad protection against multiple subtypes. In this study, we suggest a vaccination strategy using cold-adapted, live attenuated influenza vaccines (CAIVs) to provide a broad, potent, and safe cross-protection covering antigenically distinct hemagglutinin (HA) groups 1 and 2 influenza viruses...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29449833/stem-loop-rna-hairpins-in-giant-viruses-invading-rrna-like-repeats-and-a-template-free-rna
#19
Hervé Seligmann, Didier Raoult
We examine the hypothesis that de novo template-free RNAs still form spontaneously, as they did at the origins of life, invade modern genomes, contribute new genetic material. Previously, analyses of RNA secondary structures suggested that some RNAs resembling ancestral (t)RNAs formed recently de novo , other parasitic sequences cluster with rRNAs. Here positive control analyses of additional RNA secondary structures confirm ancestral and de novo statuses of RNA grouped according to secondary structure. Viroids with branched stems resemble de novo RNAs, rod-shaped viroids resemble rRNA secondary structures, independently of GC contents...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29449723/an-outbreak-of-cutaneous-leishmaniasis-in-modena-province-northern-italy-report-of-35-cases
#20
A M Cesinaro, S Nosseir, E Mataca, M C Mengoli, C Cavatorta, W Gennari
Canine Leishmaniasis is a disease endemic in many parts of Europe, carried by insects of phlebotomous species. Humans are occasional hosts of the parasites. Cases of human leishmaniasis have been registered in Italy, particularly in the southern and coastal regions. In the period 1997-2016, we collected a series of 35 patients affected by cutaneous leishmaniasis, uncovered by skin biopsy and histological examination, 21 of them found in last 3 years. The patients, 28 males and 7 female, aged between 19 and 91, resided in a restricted area of Northern Italy, and none, but two, had travelled abroad...
December 2017: Pathologica
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