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Kosuke Sakitani, Toshihiro Nishizawa, Masahide Arita, Shuntaro Yoshida, Yosuke Kataoka, Daisuke Ohki, Hiroharu Yamashita, Yoshihiro Isomura, Akira Toyoshima, Hidenobu Watanabe, Toshiro Iizuka, Yutaka Saito, Junko Fujisaki, Naohisa Yahagi, Kazuhiko Koike, Osamu Toyoshima
BACKGROUND: Helicobacter pylori eradication therapy is commonly performed to reduce the incidence of gastric cancer. However, gastric cancer is occasionally discovered even after successful eradication therapy. Therefore, we examined the prognosis of gastric cancer patients, diagnosed after successful H. pylori eradication therapy. MATERIALS AND METHODS: All-cause death rates and gastric cancer-specific death rates in gastric cancer patients who received successful H...
June 20, 2018: Helicobacter
Karine B Schlemmer, Francielli P K de Jesus, Erico S Loreto, Julia B Farias, Sydney H Alves, Laerte Ferreiro, Janio M Santurio
The yeast Malassezia pachydermatis is a common commensal and occasional opportunistic pathogen of theskin microbiota of animals and humans. In this study, the susceptibility of M. pachydermatis isolates to fluconazole (FLC), itraconazole (ITZ), ketoconazole (KTZ), clotrimazole (CLZ), and miconazole (MCZ) alone and in combination with terbinafine (TRB), nystatin (NYS), and caspofungin (CSP) was evaluated in vitro based on the M27-A3 technique and the checkerboard microdilution method using Sabouraud dextrose broth with 1% tween 80 (SDB)...
June 19, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Jingzhe Han, Tingting Wang, Yanan Xie, Duanhua Cao, Zhilei Kang, Xueqin Song
RATIONALE: Study reported an extremely rare case of trigeminal neuralgia, vestibular paroxysmia, and hemifacial spasm successively occurring in a patient with vertebrobasilar dolichoectasia (VBD). PATIENT CONCERNS: A 66-year-old female patient presented with episodic vertigo for 20 days before she was admitted to our hospital. Vertigo suddenly occurred when the patient rotated her head 20 days ago, the symptoms of vertigo were improved after continuous 1 to 3 seconds, and similar symptoms were repeated in sleep and rest, with a frequency of 30 to 40 times per day...
June 2018: Medicine (Baltimore)
Hisae Kadowaki, Hideki Nishitoh
Various types of intracellular and extracellular stresses disturb homeostasis in the endoplasmic reticulum (ER) and, thus, trigger the ER stress response. Unavoidable and/or prolonged ER stress causes cell toxicity and occasionally cell death. The malfunction or death of irreplaceable cells leads to conformational diseases, including diabetes mellitus, ischaemic diseases, metabolic diseases, and neurodegenerative diseases. In the past several decades, many studies have revealed the molecular mechanisms of the ER quality control system...
June 19, 2018: FEBS Journal
M N Baig, Abdul Halim Dzufar, Colin G Murphy, Bill Curtin
Lateral femoral prosthesis perforation is an uncommon periprosthetic fracture. Periprosthetic fractures may be fixed with open reduction and internal fixation, or with revision arthroplasty, depending on the type of fracture, the condition of the host bone in the proximal femur, the stability of the implant, and occasionally the medical co-morbidities of the patient. Proximal femoral replacement is a complex and challenging procedure but provides a better chance of early mobilisation. We describe a case of treating a 71-year-old woman who presented with an unusual type of periprosthetic fracture, treated with a revision arthroplasty procedure using a proximal femur replacement...
April 17, 2018: Curēus
S J Kim, M S Gim
Clozapine is considered to be more effective than other antipsychotic drugs for treating treatmentresistant schizophrenia. However, side effects of clozapine include agranulocytosis and, less commonly, cardiovascular disease, which is occasionally fatal. We describe a 56-year-old woman who developed clozapine-related paroxysmal supraventricular tachycardia during clozapine dose titration and had a recurrence despite being treated with verapamil. For treatment-resistant schizophrenia, a slow titration of the clozapine dose is necessary, and potential cardiac side-effects should be monitored...
June 2018: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
Aine Kavanagh, Sally Wielding, Rosemary Cochrane, Judith Sim, Anne Johnstone, Sharon Cameron
BACKGROUND: The phrase 'termination of pregnancy' has recently been adopted by a number of British medical institutions as a preferred descriptor of induced abortion. How it is used by abortion care providers is unclear, although the ongoing stigmatisation of abortion may play a role. METHODS: A mixed methods study of the views of abortion care providers in Scotland, UK. Self-administered anonymous questionnaires were distributed to abortion care providers at a national conference (Scottish Abortion Care Providers)...
April 2018: BMJ Sex Reprod Health
L Liu, L F Wang, J Z Sang, L Chen
Objective: To improve diagnosis and treatment of Castleman' s disease (CD) originating in the head and neck. Method: Of 15 cases of Castleman' s disease originating in the head and neck, 8 cases occurred in the right side of the neck, 6 cases in the left side, and 1 case in both sides. Eleven cases were focal type CD (UCD), and 4 cases were multi-center type CD (MCD). All patients underwent imaging examination and neck nephrectomy. Four patients with MCD received drug treatment after surgery. Result: During follow-up from 12 to 69 months, one patient suffered a slight facial paralysis due to a close relationship between mass and the parotid gland...
June 5, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Claire Theillac, Elisa Cinotti, Josep Malvehy, Sandra R Savle, Brigitte Balme, Philip Robinson, Jean Luc Perrot, Catherine Douchet, Anne C Biron Schneider, Llucia Alos, Adriana Garcia, Alicia Barreiro, Bruno Labeille, Gérard Duru, Stéphane Dalle, Luc Thomas, Sébastien Debarbieux
BACKGROUND: Vulvar melanosis can occasionally be clinically challenging by mimicking an early melanoma. OBJECTIVE: To report our experience of initial evaluation and follow-up in this peculiar subset of vulvar melanosis using Reflectance Confocal Microscopy (RCM). METHODS: We retrospectively evaluated 18 consecutive cases referred for atypical vulvar pigmentations and for which melanoma was considered that underwent RCM examination and histopathological assessment...
June 19, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Jin-Dong Yang, Pengju Ji, Xiao-Song Xue, Jin-Pei Cheng
Most organic transformation involves cleavage and formation of various covalent bonds, and naturally, can be regarded as a process of bond reorganization, which should be intrinsically related to bond energies (e.g., pKa, BDE, etc.). However, in many cases such as in C-H bond activation/functionalization, direct correspondence between the bond energy and reaction rate or other relevant properties is only occasionally observed when applying the bond data by simple rules like the Linear Free-energy Relationships (LFERs) in handling intricate reaction systems...
June 19, 2018: Journal of the American Chemical Society
Ami Schattner
We review the prevalence, predictability, prognosis, and preventability of atrial fibrillation and associated cardiogenic brain embolism, focusing on 'silent' subclinical atrial fibrillation (SCAF) which is very common in the elderly, and associated with significantly increased risk of stroke and cardiovascular mortality. The current paradigm treats atrial fibrillation once discovered by its symptoms, complications (stroke) or by chance, and screening recommendations are limited to opportunistic pulse palpation...
June 18, 2018: QJM: Monthly Journal of the Association of Physicians
Katya Mokretar, Daniel Pease, Jan-Willem Taanman, Aynur Soenmez, Ayesha Ejaz, Tammaryn Lashley, Helen Ling, Steve Gentleman, Henry Houlden, Janice L Holton, Anthony H V Schapira, Elizabeth Nacheva, Christos Proukakis
The α-synuclein protein, encoded by SNCA, has a key role in the pathogenesis of Parkinson's disease and other synucleinopathies. Although usually sporadic, Parkinson's disease can result from inherited copy number variants in SNCA and other genes. We have hypothesized a role of somatic SNCA mutations, leading to mosaicism, in sporadic synucleinopathies. The evidence for mosaicism in healthy and diseased brain is increasing rapidly, with somatic copy number gains of APP reported in Alzheimer's brain. Here we demonstrate somatic SNCA copy number gains in synucleinopathies (Parkinson's disease and multiple system atrophy), focusing on substantia nigra...
June 15, 2018: Brain: a Journal of Neurology
S A Martinson, S J Greenwood, D Wadowska, K Martin
Microsporidial spores were identified in the musculature of a loggerhead sea turtle Caretta caretta found dead on the shore in New Brunswick, Canada. Gastroenteritis was diagnosed on gross postmortem examination, with no gross abnormalities detected in the skeletal muscle. Histologically, the microsporidial spores were associated with inflammation and muscular necrosis and measured 1.1-1.7 × 2.2-3.4 µm. Spores were typically identified within sporophorous vesicles and, less often, in sporophorocysts and were weakly Gram positive, had punctate PAS staining, and were occasionally strongly acid-fast...
June 19, 2018: Diseases of Aquatic Organisms
Mali K Schneiter, Michael P Stany
•Cutaneous metastasis at the initial presentation of ovarian carcinoma is rare.•Clitoral metastasis in a gynecological malignancy can occasionally present as clitoral priapism.•Clitoral priapism can be treated with oral or intramuscular alpha blockade.
May 2018: Gynecologic Oncology Reports
Si-Mei He, Yan-Li Liang, Kun Cong, Geng Chen, Xiu Zhao, Qi-Ming Zhao, Jia-Jin Zhang, Xiao Wang, Yang Dong, Jian-Li Yang, Guang-Hui Zhang, Zhi-Long Qian, Wei Fan, Sheng-Chao Yang
The dried rhizomes of Coptis chinensis have been extensively used in heat clearing, dampness drying, fire draining, and detoxification by virtue of their major bioactive components, benzylisoquinoline alkaloids (BIAs). However, C. teeta and C. chinensis are occasionally interchanged, and current understanding of the molecular basis of BIA biosynthesis in these two species is limited. Here, berberine, coptisine, jatrorrhizine, and palmatine were detected in two species, and showed the highest contents in the roots, while epiberberine were found only in C...
2018: Frontiers in Plant Science
Lee Goldman
No abstract text is available yet for this article.
June 19, 2018: Circulation
Sergey V Melnikov, Keith D Rivera, Denis Ostapenko, Arthur Makarenko, Neil D Sanscrainte, James J Becnel, Mark J Solomon, Catherine Texier, Darryl J Pappin, Dieter Söll
Microsporidia are parasitic fungi-like organisms that invade the interior of living cells and cause chronic disorders in a broad range of animals, including humans. These pathogens have the tiniest known genomes among eukaryotic species, for which they serve as a model for exploring the phenomenon of genome reduction in obligate intracellular parasites. Here we report a case study to show an apparent effect of overall genome reduction on the primary structure and activity of aminoacyl-tRNA synthetases, indispensable cellular proteins required for protein synthesis...
June 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
Jamie Guillory, Kristine F Wiant, Matthew Farrelly, Leah Fiacco, Ishrat Alam, Leah Hoffman, Erik Crankshaw, Janine Delahanty, Tesfa N Alexander
BACKGROUND: Tobacco public education campaigns focus increasingly on hard-to-reach populations at higher risk for smoking, prompting campaign creators and evaluators to develop strategies to reach hard-to-reach populations in virtual and physical spaces where they spend time. OBJECTIVE: The aim of this study was to describe two novel recruitment strategies (in-person intercept interviews in lesbian, gay, bisexual, and transgender [LGBT] social venues and targeted social media ads) and compares characteristics of participants recruited via these strategies for the US Food and Drug Administration's This Free Life campaign evaluation targeting LGBT young adults who smoke cigarettes occasionally...
June 18, 2018: Journal of Medical Internet Research
M Maruf, J Jayman, M Kasprenski, K Benz, Z Feng, D Friedlander, T Baumgartner, B J Trock, H Di Carlo, P D Sponseller, J P Gearhart
BACKGROUND: Primary bladder closure of classic bladder exstrophy (CBE) is a major operation that occasionally requires intraoperative or postoperative (within 72 h) blood transfusions. OBJECTIVE: This study reported perioperative transfusion rates, risk factors for transfusion, and outcomes from a high-volume exstrophy center in primary bladder closure of CBE patients. STUDY DESIGN: A prospectively maintained, institutional exstrophy-epispadias complex database of 1305 patients was reviewed for primary CBE closures performed at the authors' institution (Johns Hopkins Hospital) between 1993 and 2017...
June 7, 2018: Journal of Pediatric Urology
Lucio Díaz-Flores, Ricardo Gutiérrez, Miriam González-Gómez, Pino García, Francisco J Sáez, Lucio Díaz-Flores, José Luis Carrasco, Juan F Madrid
Vein segmentation is a vascular remodeling process mainly studied in experimental conditions and linked to hemodynamic factors, with clinical implications. The aim of this work is to assess the morphologic characteristics, associated findings, and mechanisms that participate in vein segmentation in humans. To this end, we examined 156 surgically obtained cases of hemorrhoidal disease. Segmentation occurred in 65 and was most prominent in 15, which were selected for serial sections, immunohistochemistry, and immunofluorescence procedures...
June 18, 2018: Cells, Tissues, Organs
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