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https://www.readbyqxmd.com/read/28214754/new-pt-nnso-core-anticancer-agents-structural-optimization-and-investigation-of-their-anticancer-activity
#1
Shu Xian Chong, Yinxue Jin, Steve Chik Fun Au-Yeung, Kenneth Kin Wah To
A series of new platinum Pt(II) compounds possessing a bidentate leaving ligand modified from oxaliplatin has been synthesized, with one of the oxygen ligating atom substituted for a sulphur atom (resulting in a Pt-NNSO coordination core structure). The general structures are R,R-diaminocyclohexane (DACH)-Pt-(methylthio)acetic acid (K4) and DACH-Pt-(thiophenylacetic acid) (K4 derivatives). Substitution of an electron donating or withdrawing group at the ortho or para position on the phenyl ring of K4 derivatives was found to affect the complexes' stability, reactivity with the biological molecules (5'-guanosine monophosphate (5'-GMP) and L-methionine (L-Met)) and anticancer activity...
February 12, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28212634/time-to-re-think-physical-activity-promotion-for-young-people-results-from-a-repeated-cross-sectional-study
#2
Paul Best, Mark A Tully, Rekesh Corepal, Frank Kee, Ruth F Hunter
BACKGROUND: The aim of this study was to investigate the relationship between knowledge of the current UK physical activity (PA) guidelines and amount of daily PA using a sample population of 11-16 year olds in Northern Ireland. METHODS: Cross-sectional survey data from the 2010 and 2013 Young Persons' Behaviour and Attitudes Survey of 10,790 young people provided information on PA, knowledge of guidelines and socio-demographic characteristics. Multinomial logistic regression was used to investigate the associations between knowledge and amount of daily PA...
February 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28212622/gender-perspectives-on-views-and-preferences-of-older-people-on-exercise-to-prevent-falls-a-systematic-mixed-studies-review
#3
Marlene Sandlund, Dawn A Skelton, Petra Pohl, Christina Ahlgren, Anita Melander-Wikman, Lillemor Lundin-Olsson
BACKGROUND: To offer fall prevention exercise programs that attract older people of both sexes there is a need to understand both women's and men's views and preferences regarding these programs. This paper aims to systematically review the literature to explore any underlying gender perspectives or gender interpretations on older people's views or preferences regarding uptake and adherence to exercise to prevent falls. METHODS: A review of the literature was carried out using a convergent qualitative design based on systematic searches of seven electronic databases (PubMed, CINAHL, Amed, PsycINFO, Scopus, PEDro, and OTseeker)...
February 17, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28208682/new-approaches-to-exciting-exergame-experiences-for-people-with-motor-function-impairments
#4
Martina Eckert, Ignacio Gómez-Martinho, Juan Meneses, José-Fernán Martínez
The work presented here suggests new ways to tackle exergames for physical rehabilitation and to improve the players' immersion and involvement. The primary (but not exclusive) purpose is to increase the motivation of children and adolescents with severe physical impairments, for doing their required exercises while playing. The proposed gaming environment is based on the Kinect sensor and the Blender Game Engine. A middleware has been implemented that efficiently transmits the data from the sensor to the game...
February 12, 2017: Sensors
https://www.readbyqxmd.com/read/28202550/excess-bmi-in-childhood-a-modifiable-risk-factor-for-type-1-diabetes-development
#5
Christine Therese Ferrara, Susan Michelle Geyer, Yuk-Fun Liu, Carmella Evans-Molina, Ingrid M Libman, Rachel Besser, Dorothy J Becker, Henry Rodriguez, Antoinette Moran, Stephen E Gitelman, Maria J Redondo
OBJECTIVE: We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS: We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sex- and age- specific ceBMI thresholds for greatest type 1 diabetes risk...
February 15, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28198323/de-stress-in-a-green-space
#6
Matthew Bradby
With reference to the article on fun ways to reduce stress (students, 25 January), there is growing evidence that gardening and garden visiting is good for mental health, though more detailed studies of the specific effects are needed.
February 15, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28194825/differential-gelation-and-self-sorting-properties-of-two-isomeric-polyamides-due-to-the-parallel-vs-anti-parallel-alignment-of-backbone-dipoles
#7
Chui-Fan Leung, Hak-Fun Chow
Two isomeric bottlebrush polyamides P-1 and A-1 having the same repeating monomer dipole units aligned along the polymer backbone in pseudo-parallel and pseudo-anti-parallel, respectively, were synthesized and characterized. Both polymers can form thermoreversible gels with aromatic solvents but P-1 was found to show inferior gelation strength as compared to that of A-1. Furthermore, despite their close structural resemblance, a 1:1 mixture of the P-1 and A-1 polymers was shown to exhibit self-sorting in the gel state...
February 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28186076/multi-emr-structured-data-entry-form-user-acceptance-testing-of-a-prototype
#8
Abbas Zavar, Karim Keshavjee
Capturing standardized data from multiple EMRs at the point of care is highly desirable for a variety of uses, including quality improvement programs, multi-centered clinical trials and clinical decision support. In this paper, we describe the design, development and user acceptance testing of a prototype web-based form (the Form) that can integrate with multiple EMRs. We used the validated UTAUT questionnaire to assess the likelihood of uptake of the Form into clinical practice. The Form was found to be easy to use, elicits low anxiety, supports productivity and is perceived to have good support...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28186073/pok%C3%A3-mon-go-ubiquitous-computing-delivering-better-health-or-co-incidental-health-benefits-from-technology-use-a-participatory-observational-study
#9
Kwang Chien Yee, Ming Chao Wong, Paul Turner
Stimulating sustained behavioural change through information and technology has been an aim of much health informatics research. Traditional approaches use technology to mediate communications between health professionals and patients. More recent lifestyle technologies engage the patient directly with information and advice - but what of the phenomena that is Pokémon Go - does it point to another way of achieving health benefits through fun? This paper aims to explore some of the conceptual questions for health informatics stimulated by the phenomenal popularity of Pokémon Go...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28183689/game-based-rehabilitation-for-myoelectric-prosthesis-control
#10
Cosima Prahm, Ivan Vujaklija, Fares Kayali, Peter Purgathofer, Oskar C Aszmann
BACKGROUND: A high number of upper extremity myoelectric prosthesis users abandon their devices due to difficulties in prosthesis control and lack of motivation to train in absence of a physiotherapist. Virtual training systems, in the form of video games, provide patients with an entertaining and intuitive method for improved muscle coordination and improved overall control. Complementary to established rehabilitation protocols, it is highly beneficial for this virtual training process to start even before receiving the final prosthesis, and to be continued at home for as long as needed...
February 9, 2017: JMIR Serious Games
https://www.readbyqxmd.com/read/28182795/the-neutralizing-role-of-igm-during-early-chikungunya-virus-infection
#11
Chong-Long Chua, I-Ching Sam, Chun-Wei Chiam, Yoke-Fun Chan
The antibody isotype IgM appears earlier than IgG, within days of onset of symptoms, and is important during the early stages of the adaptive immune response. Little is known about the functional role of IgM during infection with chikungunya virus (CHIKV), a recently reemerging arbovirus that has caused large global outbreaks. In this study, we studied antibody responses in 102 serum samples collected during CHIKV outbreaks in Malaysia. We described the neutralizing role of IgM at different times post-infection and examined the independent contributions of IgM and IgG towards the neutralizing capacity of human immune sera during the early phase of infection, including the differences in targets of neutralizing epitopes...
2017: PloS One
https://www.readbyqxmd.com/read/28180114/paddle-boarding-fun-new-sport-or-an-accident-waiting-to-happen
#12
Shree-Eesh Waydia, Timothy Woodacre
BACKGROUND: Stand-up paddle-boarding is an increasingly popular water sport; however no published data to our knowledge exists on the nature and type of injuries sustained in this sport. OBJECTIVES: This study aims to describe the frequency, pattern, and mechanism of paddle-boarding injuries. MATERIALS AND METHODS: Descriptive data of paddle-boarding injuries were collected using an interactive website-based, multiple-choice survey. Data were collected from May 2012 over a 6-month period...
July 2016: Trauma Monthly
https://www.readbyqxmd.com/read/28165917/teaching-children-about-immunization-in-a-digital-age
#13
Kumanan Wilson, Katherine Atkinson, Natasha Crowcroft
We believe that public health efforts to address issues of vaccine hesitancy should increase their focus on childhood education. An opportunity exists to create positive, accurate vaccine attitudes through fun and interactive approaches early in life. Leveraging digital technologies may provide a way to deliver these messages to children in a way that complements immune system and immunization education in school curricula. We recommend that public health officials explore and identify the most effective ways to deliver positive digital messages to children in hopes of "inoculating" the next generation against vaccine hesitancy...
February 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28156056/diabetes-camp-matters-assessing-families-views-of-their-diabetes-camp-experience
#14
Jill Weissberg-Benchell, Karen Rychlik
BACKGROUND: Camp offers a safe and fun environment for learning new information about diabetes care and for trying new self-care skills. It is a place where children and teens are able to meet with others who also have diabetes and who share their experiences. MATERIALS AND METHODS: This study assessed self-reports before and after attending diabetes camp on diabetes-specific emotional distress, diabetes-specific quality of life, and self-care behaviors by surveying campers and their parents from over 42 diabetes-specific summer camps across the United States...
February 3, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28150265/-ethical-debates-related-to-the-allocation-of-medical-resources-during-the-response-to-the-mass-casualty-incident-at-formosa-fun-coast-water-park
#15
Jing-Shia Tang, Chia-Jung Chen, Mei-Chih Huang
Disasters are unpredictable and often result in mass casualties. Limited medical resources often affect the response to mass casualty incidents, undermining the ability of responders to adequately protect all of the casualties. Thus, the injuries of casualties are classified in hopes of fully utilizing medical resources efficiently in order to save the maximum possible number of people. However, as opinions on casualty prioritization are subjective, disagreements and disputes often arise regarding allocating medical resources...
February 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/28145181/linda-butler-kind-caring-and-fun
#16
Barbara Horsman, Jacky Bright
We were a small set of nursing students who gathered in September 1969 at Fulham Hospital (part of the Charing Cross Group), but even from those early days it was apparent that Linda Butler was outstanding.
February 1, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28144225/the-selfie-paradox-nobody-seems-to-like-them-yet-everyone-has-reasons-to-take-them-an-exploration-of-psychological-functions-of-selfies-in-self-presentation
#17
Sarah Diefenbach, Lara Christoforakos
Selfies appear as a double-edged phenomenon. Taking, posting, and viewing selfies has become a daily habit for many. At the same time, research revealed that selfies often evoke criticism and disrespect, and are associated with non-authenticity and narcissism. The present study (N = 238) sheds further light on the somewhat contradictory phenomenon of selfies and their psychological value. In addition to previous studies on selfies and personality traits, the present research explores relations to popular, habitual self-presentation strategies, self-reflections on own and others' selfie-taking behavior, selfie-related affect, and perceived consequences of selfies, by applying a combination of self-constructed and existing scales [e...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28143818/superhero-physiology-the-case-for-captain-america
#18
EDITORIAL
Stanley P Brown, JohnEric W Smith, Matthew McAllister, LeeAnn Joe
Using pop icons in the science classroom represents a creative way to engage often-distracted students in a relevant and, perhaps more importantly, fun way. When the pop icon is as universally known as Captain America, the pedagogical stage is set. However, when the movies can also be employed to link dramatic references to the science concepts at hand, we may have a very powerful tool by which linkages between fiction and science can be forged. In this regard, Captain America's performances in several movies to date can be used to explain actual science...
March 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/28143613/how-can-information-systems-provide-support-to-nurses-hand-hygiene-performance-using-gamification-and-indoor-location-to-improve-hand-hygiene-awareness-and-reduce-hospital-infections
#19
Rita Marques, João Gregório, Fernando Pinheiro, Pedro Póvoa, Miguel Mira da Silva, Luís Velez Lapão
BACKGROUND: Hospital-acquired infections are still amongst the major problems health systems are facing. Their occurrence can lead to higher morbidity and mortality rates, increased length of hospital stay, and higher costs for both hospital and patients. Performing hand hygiene is a simple and inexpensive prevention measure, but healthcare workers' compliance with it is often far from ideal. To raise awareness regarding hand hygiene compliance, individual behaviour change and performance optimization, we aimed to develop a gamification solution that collects data and provides real-time feedback accurately in a fun and engaging way...
January 31, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28137343/identifying-domains-of-quality-of-life-in-children-with-cancer-undergoing-palliative-care-a-qualitative-study-with-professionals
#20
Josianne Avoine-Blondin, Véronique Parent, Magali Lahaye, Nago Humbert, Michel Duval, Serge Sultan
OBJECTIVE: The goal of pediatric palliative care (PPC) is to maintain the quality of life (QoL) of children whose lives are threatened. However, there are sparse scientific data on the domains of QoL in this particular context, and no measurement strategies are available. The present study aims to describe the domains of QoL in the context of PPC in oncology, according to the perceptions of professional caregivers. METHOD: Semistructured interviews were conducted with a random sample of 20 professional caregivers from the Division of Hematology/Oncology at Le Centre Hospitalier Universitaire Sainte-Justine (Montréal, Canada)...
January 31, 2017: Palliative & Supportive Care
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