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https://www.readbyqxmd.com/read/29036814/curcumin-ameliorates-neuroinflammation-neurodegeneration-and-memory-deficits-in-p25-transgenic-mouse-model-that-bears-hallmarks-of-alzheimer-s-disease
#1
Jeyapriya Raja Sundaram, Charlene Priscilla Poore, Noor Hazim Bin Sulaimee, Tej Pareek, Wei Fun Cheong, Markus R Wenk, Harish C Pant, Sally A Frautschy, Chian-Ming Low, Sashi Kesavapany
Several studies have indicated that neuroinflammation is indeed associated with neurodegenerative disease pathology. However, failures of recent clinical trials of anti-inflammatory agents in neurodegenerative disorders have emphasized the need to better understand the complexity of the neuroinflammatory process in order to unravel its link with neurodegeneration. Deregulation of Cyclin-dependent kinase 5 (Cdk5) activity by production of its hyperactivator p25 is involved in the formation of tau and amyloid pathology reminiscent of Alzheimer's disease (AD)...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29033116/delivering-normative-feedback-to-heavy-drinking-college-students-via-text-messaging-a-pilot-feasibility-study
#2
Jennifer E Merrill, Holly K Boyle, Nancy P Barnett, Kate B Carey
Correcting misperceptions in drinking norms is an established method of reducing college student drinking; however, delivery of accurate norms has typically been limited to a single dose within the confines of an alcohol intervention. The present study tests the feasibility, acceptability, and preliminary efficacy of using text messages to promote pro-moderation descriptive and injunctive norms. Following a baseline survey, 68 heavy drinking college students were randomly assigned to receive 28 daily messages with either accurate norms information (experimental group, n=34) or fun facts (control group, n=34)...
October 5, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29032317/predictors-of-short-term-change-after-a-brief-alcohol-intervention-for-mandated-college-drinkers
#3
Kate B Carey, Jennifer E Merrill, Jennifer L Walsh, Sarah A Lust, Seth C Kalichman, Michael P Carey
OBJECTIVE: Brief motivational interventions (BMIs) reduce problematic drinking for some, but not all, college students. Identifying those students who are less responsive can help to guide intervention refinement. Therefore, we examined demographic, personality, and cognitive factors hypothesized to influence change after a BMI. METHOD: Students mandated for intervention following a campus alcohol violation (N=568; 28% female, 38% freshmen) completed a baseline assessment, then received a BMI, and then completed a 1-month follow-up...
September 28, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29030532/mechanistic-investigation-on-grinding-induced-subvisible-particle-formation-during-mixing-and-filling-of-monoclonal-antibody-formulations
#4
Benson Gikanga, Ada Hui, Yuh-Fun Maa
Processing equipment involving grinding of two solid surfaces has been demonstrated to induce subvisible particle (SvP) formation in monoclonal antibody (mAb) drug product manufacturing processes. This study elucidated potential stress types associated with grinding action to identify the stress mechanism responsible for SvP formation. Several potential stress types can be associated with the grinding action, including interfacial stresses (air-liquid and liquid-solid), hydraulic/mechanical shear stress, cavitation, nucleation of stressed protein molecules, and localized thermal stress...
October 12, 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/29025696/usability-test-of-exercise-games-designed-for-rehabilitation-of-elderly-patients-after-hip-replacement-surgery-pilot-study
#5
Yun Ling, Louis P Ter Meer, Zerrin Yumak, Remco C Veltkamp
BACKGROUND: Patients who receive rehabilitation after hip replacement surgery are shown to have increased muscle strength and better functional performance. However, traditional physiotherapy is often tedious and leads to poor adherence. Exercise games, provide ways for increasing the engagement of elderly patients and increase the uptake of rehabilitation exercises. OBJECTIVE: The objective of this study was to evaluate Fietsgame (Dutch for cycling game), which translates existing rehabilitation exercises into fun exercise games...
October 12, 2017: JMIR Serious Games
https://www.readbyqxmd.com/read/29025485/secondary-analysis-of-tuberculosis-stigma-data-from-a-cluster-randomised-trial-in-zambia-and-south-africa-zamstar
#6
V Bond, S Floyd, J Fenty, A Schaap, P Godfrey-Faussett, M Claassens, K Shanaube, H Ayles, J R Hargreaves
SETTING: Zambian and South African TB and HIV Reduction (ZAMSTAR) cluster-randomised trial (CRT) communities, 2006-2009. OBJECTIVES: To develop TB stigma items, and evaluate changes in them in response to a household intervention aimed at reducing TB transmission and prevalence but not tailored to reduce stigma. DESIGN: TB stigma was measured at baseline and 18 months later among 1826 recently diagnosed TB patients and 1235 adult members of their households across 24 communities; 12 of 24 communities were randomised to receive the household intervention...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29019631/disparities-in-life-course-outcomes-for-transition-aged-youth-with-disabilities
#7
Kruti Acharya, Regina Meza, Michael E Msall
Close to 750,000 youth with special health care needs transition to adult health care in the United States every year; however, less than one-half receive transition-planning services. Using the "F-words" organizing framework, this article explores life course outcomes and disparities in transition-aged youth with disabilities, with a special focus on youth with autism, Down syndrome, and cerebral palsy. Despite the importance of transition, a review of the available literature revealed that (1) youth with disabilities continue to have poor outcomes in all six "F-words" domains (ie, function, family, fitness, fun, friends, and future) and (2) transition outcomes vary by race/ethnicity and disability...
October 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/29016860/primary-angle-closure-glaucoma-pacg-susceptibility-gene-plekha7-encodes-a-novel-rac1-cdc42-gap-that-modulates-cell-migration-and-blood-aqueous-barrier-function
#8
Mei-Chin Lee, William Shei, Anita S Chan, Boon-Tin Chua, Shuang-Ru Goh, Yaan-Fun Chong, Maryam H Hilmy, Monisha E Nongpiur, Mani Baskaran, Chiea-Chuen Khor, Tin Aung, Walter Hunziker, Eranga N Vithana
PLEKHA7, a gene recently associated with primary angle closure glaucoma (PACG), encodes an apical junctional protein expressed in components of the blood aqueous barrier (BAB). We found that PLEKHA7 is down-regulated in lens epithelial cells and in iris tissue of PACG patients. PLEKHA7 expression also correlated with the C risk allele of the sentinel SNP rs11024102 with the risk allele carrier groups having significantly reduced PLEKHA7 levels compared to non-risk allele carriers. Silencing of PLEKHA7 in human immortalized non-pigmented ciliary epithelium (h-iNPCE) and primary trabecular meshwork cells, which are intimately linked to BAB and aqueous humor outflow respectively, affected actin cytoskeleton organization...
October 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29016199/ability-based-balancing-using-the-gross-motor-function-measure-in-exergaming-for-youth-with-cerebral-palsy
#9
Alexander MacIntosh, Lauren Switzer, Susan Hwang, Adrian L Jessup Schneider, Daniel Clarke, T C Nicholas Graham, Darcy L Fehlings
OBJECTIVE: To test if the gross motor function measure (GMFM) could be used to improve game balancing allowing youth with cerebral palsy (CP) with different physical abilities to play a cycling-based exercise videogame together. Our secondary objective determined if exergaming with the GMFM Ability-Based algorithm was enjoyable. MATERIALS AND METHODS: Eight youth with CP, 8-14 years of age, GMFM scores between 25.2% and 87.4% (evenly distributed between Gross Motor Function Classification System levels II and III), competed against each other in head-to-head races, totaling 28 unique race dyads...
October 10, 2017: Games for Health
https://www.readbyqxmd.com/read/28978975/childhood-obesity-prevention-through-a-community-based-cluster-randomized-controlled-physical-activity-intervention-among-schools-in-china-the-health-legacy-project-of-the-2nd-world-summer-youth-olympic-games-yog-obesity-study
#10
Z Wang, F Xu, Q Ye, L A Tse, H Xue, Z Tan, E Leslie, N Owen, Y Wang
BACKGROUND: Childhood obesity has been becoming a worldwide public health problem. We conducted a community-based physical activity (PA) intervention program aiming at childhood obesity prevention in general student population in Nanjing of China, the host city of the 2nd World Summer Youth Olympic Games (YOG-Obesity study). METHODS: This was a cluster randomized controlled intervention study. Participants were the 4th (Mean age±s.e.: 9.0±0.01) and 7th (Mean age±s...
October 5, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28978131/intravoxel-incoherent-motion-mr-imaging-in-nasopharyngeal-carcinoma-comparison-and-correlation-with-dynamic-contrast-enhanced-mr-imaging
#11
Vincent Lai, Victor Ho Fun Lee, Ka On Lam, Bingsheng Huang, Queenie Chan, Pek Lan Khong
OBJECTIVES: To compare accuracy and assess agreement between intravoxel incoherent motion (IVIM) magnetic resonance (MR) perfusion-related parameters and quantitative dynamic contrast-enhanced (DCE) MR parameters in nasopharyngeal carcinoma (NPC). RESULTS: D, f, D*, K(trans) , Kep and Vp were significantly lower in the high stage group while Ve was significantly higher in the high stage group. Optimal cut-off values were: D=0.749 × 10(-3) mm(2)/s; f=0.145; D*=100...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976806/magnetic-compression-anastomosis-magnamosis-for-functional-undiversion-of-ileostomy-in-pediatric-patients
#12
Luzia Toselli, Marcelo Martinez-Ferro, Guillermo Cervio, Dillon Kwiat, Jill Imamura-Ching, Claire E Graves, Brandon Gaston, Michael Harrison
INTRODUCTION: Magnamosis forms a compression anastomosis using self-aligning magnetic Harrison rings. The device has been approved by the Food and Drug Administration for first-in-human testing and has been applied in adults for intestinal anastomosis during urologic reconstructions. We now report the first cases of magnamosis to functionally undivert the fecal stream from a previously created loop ileostomy in pediatric patients. MATERIALS AND METHODS: Case 1: A 4-year-old male underwent a diverting loop ileostomy for malignant bowel obstruction...
October 4, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28965305/conversion-of-sago-metroxylon-sagu-pith-waste-to-fermentable-sugars-via-a-facile-depolymerization-process
#13
Suh Cem Pang, Lee Ken Voon, Suk Fun Chin
The conversion of starchy sago (Metroxylon sagu) pith waste (SPW), a lignocellulosic biomass waste, to fermentable sugars under mild conditions had been successfully demonstrated. The optimum depolymerization of SPW was achieved at 2 wt% sample loading which was catalyzed by 100 mM of oxalic acid in the presence of 25 wt% NaCl solution at 110 °C for 3 h. Up to 97% SPW sample was being converted into fermentable sugars with limited formation of by-products after two sequential depolymerization cycles. Both reaction temperature and concentration of oxalic acid were crucial parameters for the depolymerization of SPW which exhibited a high selectivity for the production of glucose over other reducing sugars...
September 30, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28961164/three-types-of-intimate-relationships-among-individuals-with-chronic-pain-and-a-history-of-trauma-exposure
#14
Carissa van den Berk-Clark, Terri L Weaver, F David Schneider
Individuals with chronic pain often have psychiatric disorders, such as depression and posttraumatic stress disorder (PTSD), which can affect their intimate relationship satisfaction and stability. Little is known about the nature of support stemming from chronic pain patients' intimate relationships, and therefore, this study sought to: (1) use cluster modeling to construct specific intimate relationship groups based on types of support patients receive, and (2) determine if there is a relationship between support type and PTSD, chronic pain, anxiety, and depression...
September 29, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28954791/mii-vitalise-a-pilot-randomised-controlled-trial-of-a-home-gaming-system-nintendo-wii-to-increase-activity-levels-vitality-and-well-being-in-people-with-multiple-sclerosis
#15
Sarah Thomas, Louise Fazakarley, Peter W Thomas, Sarah Collyer, Sarah Brenton, Steve Perring, Rebecca Scott, Fern Thomas, Charlotte Thomas, Kelly Jones, Jo Hickson, Charles Hillier
OBJECTIVES: While the health and well-being benefits of physical activity are recognised, people with multiple sclerosis (MS) often face greater barriers than the general population. The Nintendo Wii potentially offers a fun, convenient way of overcoming some of these. The aim was to test the feasibility of conducting a definitive trial of the effectiveness and cost-effectiveness of Mii-vitaliSe; a home-based, physiotherapist-supported Nintendo Wii intervention. DESIGN: A single-centre wait-list randomised controlled study...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28953185/creative-dance-practice-improves-postural-control-in-a-child-with-cerebral-palsy
#16
Kate Stribling, Jennifer Christy
PURPOSE: To investigate the effect of creative dance instruction on postural control and balance in an 11-year-old with spastic triplegic cerebral palsy, Gross Motor Function Classification Scale level II. DESCRIPTIONS: We conducted 1-hour dance interventions twice weekly for 8 weeks, with a focus on somatosensory awareness and movement in all planes of motion. Computerized dynamic posturography using the SMART Balance Master/EquiTest (NeuroCom) was used to assess postural control and balance reactions before the first class and following the final class...
October 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28938718/looking-back-forward-looking
#17
Scott C Edmunds, Nicole A Nogoy, Hans Zauner, Peter Li, Christopher I Hunter, Xiao Si Zhe, Laurie Goodman
GigaScience is now 5 years old, having been launched at the 2012 Intelligent Systems for Molecular Biology conference. Anyone who has attended what is the largest computational biology conference since then has had the opportunity to join us for each birthday celebration-and receive 1 of our fun T-shirts as a party prize. Since launching, we have pushed our agenda of openness, transparency, reproducibility, and reusability. Here, we look back at our first 5 years and what we have done to forward our open science goals in scientific publishing...
September 1, 2017: GigaScience
https://www.readbyqxmd.com/read/28934666/behavioral-approach-and-orbitofrontal-cortical-activity-during-decision-making-in-substance-dependence
#18
Dorothy J Yamamoto, Marie T Banich, Michael F Regner, Joseph T Sakai, Jody Tanabe
Behavioral approach, defined as behavior directed toward a reward or novel stimulus, when elevated, may increase one's vulnerability to substance use disorder. Behavioral approach has been associated with relatively greater left compared to right frontal activity; behavioral inhibition may be associated with relatively greater right compared to left frontal brain activity. We hypothesized that substance dependent individuals (SDI) would have higher behavioral approach than controls and greater prefrontal cortical activity during decision-making involving reward...
September 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28934624/gamification-of-medication-adherence-in-epilepsy
#19
REVIEW
Mohammad Izzat Abdul Rahim, Rhys Huw Thomas
Adherence to medication regimens is a crucial factor in seizure-freedom and well-being for people with epilepsy. In contrast, taking medication inconsistently increases the risk of not only seizures and their adverse effects, but drug side-effects and unnecessary modifications to treatment plans. Epilepsy is prevalent across all age groups and we have been slow to utilise both the technologies and psychologies derived from computer gaming. Gaming has broken through to the mainstream and is no longer the preserve of younger males, mirroring the adoption of smart-phones...
September 14, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28933921/are-you-ready-to-have-fun-the-spanish-state-form-of-the-state-trait-cheerfulness-inventory
#20
Raúl López-Benítez, Alberto Acosta, Juan Lupiáñez, Hugo Carretero-Dios
Although cheerfulness, seriousness, and bad mood as traits have been widely studied as the basis of sense of humor, data are scarce regarding the same dimensions as states. In this study, we adapted the state form of the State-Trait-Cheerfulness Inventory (STCI-S) into Spanish. At the same time, we empirically tested new predictions. We assessed 5 independent samples accounting for 1,029 participants (647 women) with ages ranging from 18 to 78 years. We confirmed the 3-dimensional structure as well as a strong measurement invariance between men and women...
September 21, 2017: Journal of Personality Assessment
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