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Hypothyroidism in children

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https://www.readbyqxmd.com/read/29454373/subclinical-hypothyroidism-in-children-is-it-always-subclinical
#1
R Gallizzi, C Crisafulli, T Aversa, G Salzano, F De Luca, M Valenzise, G Zirilli
Aim of this commentary is to report current knowledges on the main clinical and metabolic abnormalities which might be observed in children with longstanding and untreated subclinical hypothyroidism (SH) and to comment the most recent views about natural evolution of thyroid function in the cases with either idiopathic or Hashimoto's thyroiditis-related SH. On the basis of these preliminary remarks, the essential guidelines for an appropriate and tailored management of SH children are also proposed.
February 17, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29451227/statural-growth-and-prevalence-of-endocrinopathies-in-relation-to-liver-iron-content-lic-in-adult-patients-with-beta-thalassemia-major-btm-and-sickle-cell-disease-scd
#2
Mohamed A Yassin, Ashraf T Soliman, Vincenzo De Sanctis, Mohammad Aj Abdula, Lubna M Riaz, Firdous F Ghori, Anil Yousaf, Abdulqadir J Nashwan, Sandara Abusamaan, Abbas Moustafa, Samah Kohla, Dina S Soliman
Despite regular blood transfusion and iron chelation therapy, growth impairment and pubertal delay are commonly seen in children and adolescents with transfusion-dependent Beta thalassaemia major (BTM) and sickle cell disease (SCD). We evaluated growth parameters and endocrine disorders in relation to the liver iron concentration (LIC) assessed by the Ferriscan® method in a cohort of adults with SCD (n =40) and BTM (n = 52) receiving blood transfusions and iron chelation therapy since early childhood. Before transfusion, hemoglobin concentration had not been less than 9 g/dl in the past 12 years; subcutaneous daily desferrioxamine was administered for all of them since early childhood (2- 5 years of age)...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29451226/final-adult-height-and-endocrine-complications-in-young-adults-with-%C3%AE-thalassemia-major-tm-who-received-oral-iron-chelation-oic-in-comparison-with-those-who-did-not-use-oic
#3
Ashraf T Soliman, Mohamed A Yassin, Vincenzo De Sanctis
BACKGROUND: Relatively little is known about endocrine function, bone mineral health, and growth during oral iron chelation therapy in β-thalassemia major patients (TM) on treatment with deferasirox. AIMS OF THE STUDY: To study the frequency of endocrine complications, IGF-1 levels and final adult standing height (FA-Ht) in patients with BTM in two groups of adult patients. PATIENTS AND METHODS: The first group (Group A; 15 patients, 6 females and 9 males) received oral iron chelation therapy (OIC) with deferasirox for 6 years before puberty; the second group (Group B;40 patients) attained the FA-Ht before the use of OIC (iron chelation therapy with deferoxamine (DFO) given subcutaneously, since the age of 2 years)...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29423669/normative-data-of-thyroid-gland-volume-in-south-indian-neonates-and-infants
#4
Sudha Rathna Prabhu, Shriraam Mahadevan, Sujatha Jagadeesh, Dharani Dharan, Chandra Ganesh, Seshadri Suresh, Indrani Suresh
OBJECTIVE: To establish normative ultrasound data for thyroid gland volume in South Indian neonates and infants and compare with abnormal sonological features of thyroid in congenital hypothyroidism (CH) to explore thyroid ultrasound utility as a supportive screening tool to newborn screening programs for early detection of CH. METHODS: In view of impact of geo ethnic factors, varying growth velocities and body mass indices of human population worldwide, specific regional, age and gender related reference data for thyroid gland size and volume are vital...
February 9, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29402856/evaluation-of-dynamic-thiol-disulphide-homeostasis-in-children-and-adolescents-with-non-autoimmune-subclinical-hypothyroidism
#5
Seyit Ahmet Ucakturk, Murat Alışık, Çagatay Ugur, Selin Elmaogullari, Eda Mengen, Özcan Erel
<br>To evaluate the thiol/disulphide homeostasis in children with non-autoimmune subclinical hypothyroidism. <br> Materials (Subjects) and Methods<br>Thiol-disulphide homeostasis [native thiol-disulphide exchanges (native thiol (SH), disulphide (SS), and total thiol (SS+SH))] was evaluated in 60 children and adolescents who were negative for thyroid auto-antibodies (anti-thyroid peroxidase, anti-thyroglobulin) and had a TSH value higher than 5 mIU/L and in 40 sex- and age-matched healthy control subjects who were negative for thyroid auto-antibodies and had normal TSH levels...
January 25, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29402813/low-ft4-concentrations-around-the-start-of-recombinant-human-growth-hormone-treatment-predictor-of-congenital-structural-hypothalamic-pituitary-abnormalities
#6
Laura van Iersel, Hanneke M van Santen, Gladys R J van Zandwijken, Nitash Zwaveling-Soonawala, Anita C S Hokken-Koelega, A S Paul van Trotsenburg
BACKGROUND: Growth hormone (GH) treatment may unmask central hypothyroidism (CeH). This was first observed in children with GH deficiency (GHD), later also in adults with GHD due to acquired "organic" pituitary disease. We hypothesized that newly diagnosed CeH in children after starting GH treatment for nonacquired, apparent isolated GHD points to congenital "organic" pituitary disease. METHODS: Nationwide, retrospective cohort study including all children with nonacquired GHD between 2001 and 2011 in The Netherlands...
January 18, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29396214/hypothyroidism-during-pregnancy-and-its-association-to-perinatal-and-obstetric-morbidity-a-review
#7
María Martínez, Berta Soldevila, Anna Lucas, Inés Velasco, Lluis Vila, Manel Puig-Domingo
There is currently no consensus among the different scientific societies on screening for thyroid dysfunction in the first trimester of pregnancy. Indeed, diagnosis and treatment of subclinical hypothyroidism during pregnancy are controversial, as no cut-off value for thyrotropin (TSH) is universally accepted. TSH measurement may be influenced by different factors throughout pregnancy, but especially during the first trimester. The association between overt hypothyroidism during pregnancy and obstetric and perinatal complications is well established...
February 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29386146/positivity-of-antineutrophil-cytoplasmic-antibodies-in-children-prevalence-and-etiologies
#8
Ameni Jerbi, Sawsan Feki, Salma Ben Ameur, Hend Hachicha, Lamia Gargouri, Thouraya Kamoun, Abdelmajid Mahfoudh, Mongia Hachicha, Hatem Masmoudi
In adults, anti-neutrophil cytoplasmic antibodies (ANCA) are considered as serological markers of several diseases, especially vasculitis and glomerulonephritis. Since ANCA are rarely positive in children, few data about the clinical relevance of these auto-antibodies in pediatric population have been reported. Therefore, our study aims to describe the spectrum of disorders associated with positive ANCA in Tunisian children. This study had been carried out over a period of 12 years and a half. All patients under the age of 15 for whom ANCA screening was performed in our laboratory were included...
January 1, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29373441/the-impact-of-thyroid-autoimmunity-on-thyroid-function-in-12-year-old-children-with-celiac-disease
#9
Fredrik Norström, Maria van der Pals, Anna Myléus, Solveig Hammarroth, Lotta Högberg, Anders Isaksson, Anneli Ivarsson, Annelie Carlsson
OBJECTIVES: Celiac disease (CD) is associated with thyroid autoimmunity and other autoimmune diseases. However, data are lacking regarding the relationship between thyroid autoimmunity and thyroid function, especially in regard to CD. Our aim was to investigate the impact of thyroid autoimmunity on thyroid function in 12-year-old children with CD compared to their healthy peers. METHODS: A case-referent study was conducted as part of a CD screening of 12-year-olds...
January 25, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29369370/evaluation-of-qt-dispersion-and-tp-e-interval-in-children-with-subclinical-hypothyroidism
#10
Alper Akın, Edip Unal, Ruken Yıldırım, Mehmet Türe, Hasan Balık, Yusuf Kenan Haspolat
BACKGROUND: Studies on adults, have shown increased dispersion of QT and corrected QT (cQT), peak-to-end interval of the T wave (Tp-e), Tp-e/QT ratio and Tp-e/QTc ratio in subclinical hypothyroidism (SH), but there have been no paediatric studies MATERIALS AND METHODS: A total of 40 SH patients were compared with 40 healthy children in respect of serum thyroid stimulating hormone (TSH), serum free level of triiodothyronine (fT3) and free level of thyroxine (fT4). SH diagnosis was accepted as TSH above the laboratory accepted upper limit (> 4...
January 25, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29344467/longitudinal-change-in-thyroid-hormone-levels-in-children-with-epilepsy-on-a-ketogenic-diet-prevalence-and-risk-factors
#11
Yun-Jin Lee, Sang Ook Nam, Kyung-Min Kim, Young Mi Kim, Gyu Min Yeon
Background and Purpose: The aim of this study is to evaluate the prevalence of hypothyroidism and the change of thyroid hormone level in the children with epilepsy on a ketogenic diet (KD). Methods: The levels of serum free thyroxine (fT4) and thyroid-stimulation hormone (TSH) were measured at the start of the KD and at 6- to 12-month intervals in children with intractable epilepsy. Hypothyroidism was defined as fT4 level < 0.8 ng/dL and TSH level > 6.0 μIU/mL...
December 2017: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/29343289/differentiated-thyroid-carcinoma-presentation-may-be-more-aggressive-in-children-and-adolescents-than-in-young-adults
#12
Giuseppina Zirilli, Laura Cannavò, Francesco Vermiglio, Maria Antonia Violi, Filippo De Luca, Malgorzata Wasniewska
BACKGROUND: The available studies concerning the influence of age on the phenotypical expression of differentiated thyroid carcinoma (DTC) have hitherto compared DTC presentation either between pre-pubertal and pubertal children or between pediatric patients and aged adults; aim of this study was to ascertain for the first time whether presentation of DTC may significantly vary according to age, even within a peculiar study population covering only young patients aged less than 30 years...
January 17, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29333819/hashimoto-s-disease-in-a-cohort-of-29-children-and-adolescents-epidemiology-clinical-course-and-comorbidities-in-the-short-and-long-term
#13
Eliot Gómez López, Ana P Nso-Roca, Mercedes Juste Ruiz, Ernesto Cortés Castell
Hashimoto's thyroiditis is the most common cause of goiter and hypothyroidism among children and adolescents. Its clinical manifestations and course vary. The objective of this study was to review the clinical and evolutionary characteristics of Hashimoto's disease in the pediatric population. Clinical, analytical, ultrasound, epidemiological, and evolutionary data of patients with autoimmune thyroiditis seen at Hospital Universitario San Juan de Alicante between January 2010 and January 2016 were analyzed...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29325223/maternal-thyroid-hormone-insufficiency-during-pregnancy-and-risk-of-neurodevelopmental-disorders-in-offspring-a-systematic-review-and-meta-analysis
#14
William Thompson, Ginny Russell, Genevieve Baragwanath, Justin Matthews, Bijay Vaidya, Jo Thompson-Coon
BACKGROUND: In the last two decades, several studies have examined the association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children and shown conflicting results. AIM: This systematic review aimed to assess the evidence for an association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children. We also sought to assess whether levothyroxine treatment for maternal thyroid hormone insufficiency improves child neurodevelopment outcomes...
January 11, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29325028/tsh-and-ft4-concentrations-in-congenital-central-hypothyroidism-and-mild-congenital-thyroidal-hypothyroidism
#15
Nitash Zwaveling-Soonawala, A S Paul van Trotsenburg, Paul H Verkerk
Context: In central hypothyroidism (CeH) free thyroxine (FT4) concentrations are low while TSH concentrations may be low, normal or even slightly elevated due to reduced bioactivity. Congenital CeH (CCeH) may be isolated or part of multiple pituitary hormone deficiency (MPHD). Objective: To test our hypotheses that (1) TSH concentrations have a more U-shaped distribution in children with CCeH compared to children with a normally functioning hypothalamic-pituitary-thyroid-axis, and (2) TSH concentrations in children with CCeH with MPHD are higher compared to children with isolated CCeH...
January 9, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29306930/management-of-thyrotoxicosis-in-children-and-adolescents-35-years-experience-in-304-patients
#16
Fereidoun Azizi, Atieh Amouzegar
BACKGROUND: Diffuse toxic goiter accounts for about 15% of all childhood thyroid diseases. There is great controversy over the management of Graves' disease in children and adolescents. This article reports our experience in 304 children and juvenile patients with Graves' disease. METHODS: Between 1981 and 2015, 304 patients aged 5-19 years with diffuse toxic goiter were studied, of whom 296 patients were treated with antithyroid drugs (ATD) for 18 months. Patients with persistent or relapsed hyperthyroidism who refused ablative therapy with surgery or radioiodine were managed with continuous methimazole (MMI) treatment...
January 8, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29303778/veganism-as-a-cause-of-iodine-deficient-hypothyroidism
#17
Olga Yeliosof, Lawrence A Silverman
BACKGROUND: Iodine deficiency is the most common cause of acquired hypothyroidism worldwide. Although uncommon in the Western world, the incidence of iodine deficiency may be rising due to the increased use of restrictive diets. CASE PRESENTATION: We present a 23-month-old boy diagnosed with iodine deficiency hypothyroidism, induced by a vegan diet. CONCLUSIONS: This case highlights the risk for iodine deficiency in children on a vegan diet after discontinuation of breast/formula feeding that could lead to acquired hypothyroidism...
January 26, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29285443/cardiovascular-risk-factors-in-children-and-adolescents-with-subclinical-hypothyroidism
#18
Yogesh Yadav, Uma Kaimal Saikia, Dipti Sarma, Manoj Hazarika
Background: Subclinical hypothyroidism (SCH) is a commonly encountered entity in day-to-day clinical practice and has been associated with adverse cardiovascular risk profile in adults and children. Data on children and adolescents with SCH, from India, are limited. Materials and Methods: This study was a cross-sectional case-control study, conducted at a tertiary care center in Northeast India. Twenty-seven children and adolescents aged 11 ± 2.4 years with SCH and thyroid-stimulating hormone >7...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29285442/prevalence-and-etiological-profile-of-short-stature-among-school-children-in-a-south-indian-population
#19
Kumaravel Velayutham, S Sivan Arul Selvan, R V Jeyabalaji, S Balaji
Background and Objectives: Short stature (SS) is a common pediatric problem and it might be the first sign of underlying illness. Studies documenting the burden and etiological profile of SS are scarce from India and are mostly limited to data obtained from referral centers. Due to the lack of large-scale, community-based studies utilizing a standard protocol, the present study aimed to assess the prevalence and etiological profile of SS in school children of a South Indian district. Materials and Methods: In this cross-sectional study, children aged 4-16 years from 23 schools in Madurai district, Tamil Nadu, underwent anthropometric measurements and height was plotted in Khadilkar et al...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29262478/-clinical-characteristics-of-thyroid-hormone-resistance-syndrome-in-two-cases-with-different-subtypes
#20
H Sun, X L Chen, T Chen, H Y Wu, R R Xie, F Y Wang, X Y Wang, L Q Chen
Objective: To analyze the clinical characteristics of children with two types of thyroid hormone resistance (RTH) syndrome, and to detect the variants of thyroid hormone receptor alpha(TRα) and TRβ gene in children. Method: Two children with RTH were reported in regard to clinical manifestation, laboratory examination and genetic variants. Some related reports in literature were reviewed. Result: Case 1 was a girl, 10 years old, with thyroid enlargement for several days and without thyrotoxicosis. Laboratory work-up revealed that free thyroxine (FT(4)) was 65...
December 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
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