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Hypothyroidism in children

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https://www.readbyqxmd.com/read/28538388/myxedema-coma-a-case-report-of-pediatric-emergency-care
#1
Yueniu Zhu, Wenjuan Qiu, Mengyan Deng, Xiaodong Zhu
RAIONALE: Myxedema coma (MC) is extremely rare but lethal in pediatric patients with hypothyroidism leading to altered mental status and hypothermia. But there is no clinical guideline for such cases. PATIENT CONCERNS: A 6-year-old Chinese girl presented with coma and hypothermia preceded by pneumonia. Her lab results were: free thyroxin (T4) 4.18 pmol/L and thyroid-stimulating hormone (TSH) > 150 μIU/mL with extremely elevated anti-thyroid peroxidase (TPO-Ab) and anti-thyroglobulin...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28534114/pediatric-hypothyroidism-diagnosis-and-treatment
#2
Ari J Wassner
Thyroid hormone has important physiologic functions in nearly every organ system. The critical role of thyroid hormone in growth and in physical and neurologic development lends particular importance to the prompt diagnosis and appropriate treatment of hypothyroidism in infants and children. Congenital hypothyroidism is common and has potentially devastating neurologic consequences. While the approach to diagnosis and treatment of severe congenital hypothyroidism is well established, data continue to emerge about the genetic causes, clinical significance, and prognosis of the milder forms of congenital hypothyroidism that are increasingly being diagnosed by newborn screening...
May 22, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28529200/occurrence-of-hyperprolactinemia-in-children-with-subclinical-hypothyroidism
#3
Neera Sharma, Deep Dutta, Lokesh Sharma
BACKGROUND: Prevalence of hyperprolactinemia in children with subclinical hypothyroidism (ScH) is not known. This study aimed to determine the occurrence and predictors of hyperprolactinemia in children with euthyroidism, ScH and overt primary hypothyroidism (OPH). METHODS: Consecutive children <18 years age, diagnosed to have normal thyroid function, ScH or OPH underwent serum prolactin estimation. Children with pituitary adenomas, secondary hypothyroidism, multiple pituitary hormone deficiency, comorbid states and drug-induced hyperprolactinemia were excluded...
May 22, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28525352/evaluation-of-endocrine-and-metabolic-dysfunctions-after-hematopoietic-stem-cell-transplantation-in-children-a-study-from-turkey
#4
Dilek Gurlek Gokcebay, Fatih Azik, Cengiz Bayram, Arzu Yazal Erdem, Ali Fettah, Pamir Isik, Nese Yarali, Fatma Demirel, Bahattin Tunc, Namik Ozbek
BACKGROUND: Endocrine organs are highly susceptible to effects of high-dose chemotherapy. The objective of the study was to evaluate endocrine and metabolic complications after hematopoietic stem cell transplantation (HSCT) in children. METHODS: The patients who underwent HSCT in our center from April 2010 to October 2014 with at least 1 year follow-up were analyzed retrospectively. RESULTS: One-hundred children (M/F:59/41; mean age 8.9±4...
May 18, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28523891/neonatal-endocrinologic-problems-in-collodion-babies
#5
Ahmet Ozdemir, Sabriye Korkut, Selim Kurtoglu, Nihal Hatipoglu, Tamer Gunes, Mehmet Adnan Ozturk
OBJECTIVES: To identify endocrinologic problems, particularly those concerning growth, in collodion babies (CBs). METHODS: Clinically identified newborn CBs were included in the study group (group 1). Because CBs are generally born premature, small for gestational age (SGA), or both, a control group matched to the study group in terms of gestational age and birthweight (group 2) was also established. Blood specimens were collected from both groups for thyroid function tests and to measure serum growth hormone (GH), insulinlike growth factor 1 (IGF-1) and IGF binding protein-3 (IGFBP-3) levels...
May 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28508616/ultrasound-elastography-in-pediatric-congenital-hypothyroid-patients
#6
Mehmet Akif Sarıca, Tahir Dalkıran, Mehmet Sait Menzilcioğlu, Mahmut Duymuş, Nursel Yurttutan
OBJECTIVES: Congenital hypothyroidism (CH) is most frequently encountered in newborns as an endocrine disorder characterized by thyroid hormone deficiency, and is one of the most common reasons for preventable mental retardation. This prospective study was designed to detect the pediatric occurrences of CH followed as euthyroid, with no anomalies detected via US on the gray scale, in comparison with a pediatric group with normal levels. METHODS: A total of 42 apparently healthy children with no thyroid disorder (Group 1) and 54 euthyroid CH (Group 2) using thyroid hormone were included in this study...
September 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28508608/myopathy-in-pediatric-thyroid-states-a-review-of-the-literature
#7
Elena Dingle, Resmy Palliyil-Gopi, Maria Contreras, Brenda Kohn, Preneet Cheema Brar
This review highlights the presentations of myopathy in children in both hypothyroid and hyperthyroid states with an emphasis on the pathophysiology, diagnosis and treatment. Based on our review of the literature data, myopathy should be considered in all children presenting with muscular weakness or altered muscle enzymes in the context of thyroid disease.
December 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28502134/thyroid-dysfunctions-in-a-sample-of-egyptian-children-and-adolescents-with-systemic-lupus-erythematosus-relation-to-disease-activity-and-duration
#8
Hend H Abd-Elnabi, Mohamed A El-Gamasy, Maher A Abd-Elhafez
Systemic lupus erythematosus (SLE) is a chronic, autoimmune, inflammatory disease affects any organ of the body, including the thyroid gland. Both hypothyroidism and hyperthyroidism have been found in SLE patients more frequently than general population. The aim of this study was to evaluate the frequency of autoimmune thyroid dysfunctions in juvenile SLE and its relation to disease activity and duration. A prospective case-control study was carried on 40 children with juvenile SLE and 30 healthy as controls, all were subjected to measurement of serum TSH, Free T3, Free T4 and anti-TG by ELISA...
June 2016: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/28489513/thyroid-function-during-early-life-and-dental-development
#9
S Vucic, T I M Korevaar, B Dhamo, V W V Jaddoe, R P Peeters, E B Wolvius, E M Ongkosuwito
Children with low levels of thyroid hormones (hypothyroidism) have delayed tooth eruption, enamel hypoplasia, micrognathia, and anterior open bite, whereas children with hyperthyroidism may suffer from accelerated tooth eruption, maxillary, and mandibular osteoporosis. However, it is still unknown whether thyroid function variations within the normal or subclinical range also have an impact on hard dental tissues in healthy children. The objective of this study was, therefore, to investigate the association between thyroid function from the fetal period until early childhood and dental development at school age...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28467346/chronic-anemia-and-thyroid-function
#10
Ashraf T Soliman, Vincenzo De Sanctis, Mohamed Yassin, Magda Wagdy, Nada Soliman
Anaemia is a global public health problem affecting both developing and developed countries with major consequences for human health as well as social and economic development. It occurs at all stages of the life cycle, but is more prevalent in pregnant women and young children. Iron deficiency anaemia (IDA) impairs thyroid metabolism in animals and human and may negatively affect growth and develpment of children. On the other hand both overt and subclinical hypothyroidism are associated with anemia and adding iron to thyroxine therapy improves both conditions compared to thyroxine therapy alone...
April 28, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28461213/survival-and-late-effects-after-allogeneic-hematopoietic-cell-transplantation-for-hematologic-malignancy-at-less-than-three-years-of-age
#11
Lynda M Vrooman, Heather R Millard, Ruta Brazauskas, Navneet S Majhail, Minoo Battiwalla, Mary E Flowers, Bipin N Savani, Görgün Akpek, Mahmoud Aljurf, Rajinder Bajwa, K Scott Baker, Amer Beitinjaneh, Menachem Bitan, David Buchbinder, Eric Chow, Christopher Dandoy, Andrew C Dietz, Lisa Diller, Robert Peter Gale, Shahrukh K Hashmi, Robert J Hayashi, Peiman Hematti, Rammurti T Kamble, Kimberly A Kasow, Morris Kletzel, Hillard M Lazarus, Adriana K Malone, David I Marks, Tracey A O'Brien, Richard F Olsson, Olle Ringden, Sachiko Seo, Amir Steinberg, Lolie C Yu, Anne Warwick, Bronwen Shaw, Christine Duncan
Very young children undergoing hematopoietic cell transplantation (HCT) are a unique and vulnerable population. We analyzed outcomes of 717 patients from 117 centers who survived relapse-free for ≥1 year following allogeneic myeloablative HCT for hematologic malignancy at <3 years-of-age, between 1987-2012. Median follow-up was 8.3 years (range 1.0-26.4 years); median age at follow-up was 9 years (range 2-29 years). Ten-year overall and relapse-free survival were 87% (95% CI 85-90%) and 84% (95% CI 81-87%)...
April 28, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28458461/endocrine-status-of-patients-with-septo-optic-dysplasia-fourteen-japanese-cases
#12
Mikiko Koizumi, Shinobu Ida, Yasuko Shoji, Yuri Etani, Yoshikazu Hatsukawa, Nobuhiko Okamoto
A clinical diagnosis of septo-optic dysplasia (SOD) is made when two or more of the classical triad of optic nerve hypoplasia, pituitary hormone abnormalities or midline brain defects. To date, a clinical study of SOD, regarding its endocrinological features in particular, has not been undertaken in Japan. We retrospectively evaluated 14 SOD patients at our institution. Hormonal dysfunction was present in 78% of cases: ten cases presented combined hypopituitarism and one case presented precocious puberty. GHD and hypothyroidism were the most common endocrinopathies...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/28458459/hypothyroidism-among-pediatric-patients-with-type-1-diabetes-mellitus-from-patients-characteristics-to-disease-severity
#13
Ali Fatourechi, Hossein Malekafzali Ardakani, Fatemeh Sayarifard, Mahdi Sheikh
We performed this study to evaluate the associations of hypothyroidism with clinical severity and the occurrence of diabetic ketoacidosis (DKA) at initial diagnosis among pediatric patients with type 1 diabetes mellitus (T1DM). 330 children with T1DM who referred to Diabetes Clinic were enrolled. The medical records were e valuated and a blood sample was drawn from patients for measuring thyroid function and antibodies, blood glucose, and glycated hemoglobin (HbA1C) levels. Hypothyroidism was detected in 9...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/28447527/serum-thyroid-hormone-levels-among-chinese-pregnant-women
#14
Yunxian Yu, Xiawei Li, Shuying Jiang, Wen Jiang, Jinhua Wu, Zhaopin Wang, Shuojia Wang, Minchao Li, Haigeng Xu, Yun Lv, Jinxing Jiang, Yongfeng Ding, Boer Zhang
AIM: The aim of this study is to examine gestational serum thyroid hormone levels and influencing factors among Chinese pregnant women with high dietary iodine intake. METHODS: The study was conducted from 2011 and 2013 in Zhoushan Women & Children's Hospital, Zhejiang, China. A total of 1991 pregnant women were enrolled and their serum levels of free thyroid hormones (FT4, FT3, and TSH) were detected by chemiluminescence method. RESULTS: Gestational serum FT4 and FT3 decreased with gestational week while TSH increased...
April 27, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28444954/clinical-presentation-and-outcome-of-children-with-central-diabetes-insipidus-associated-with-a-self-limited-or-transient-pituitary-stalk-thickening-diagnosed-as-infundibuloneurohypophysitis
#15
J Schaefers, M Cools, K De Waele, I Gies, V Beauloye, P Lysy, I Francois, D Beckers, J De Schepper
OBJECTIVE: Despite lymphocytic or autoimmune infundibuloneurohypophysitis (INH) is an increasingly recognized etiology in children with central diabetes insipidus, clinical data on epidemiology (clinical evolution, predisposing factors, complications), diagnosis and management of this entity are limited and mostly based on published case reports. The aim of this study was to gain a broader insight in the natural history of this disease by analyzing the clinical presentation, radiological pituitary stalk changes, associated autoimmunity and hormonal deficiencies in children with CDI and a self-limiting or transient stalk thickening (ST), diagnosed as autoimmune INH, during the last 15 years in four Belgian university hospitals...
April 26, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28443262/a-rare-association-of-central-hypothyroidism-and-adrenal-insufficiency-in-a-boy-with-williams-beuren-syndrome
#16
Devi Dayal, Dinesh Giri, Senthil Senniappan
Primary hypothyroidism related to morphological and volumetric abnormalities of the thyroid gland is one of the commonest of several endocrine dysfunctions in Williams-Beuren syndrome (WBS). We report a 10-month-old boy with WBS who presented with central hypothyroidism. During the neonatal period, he had prolonged jaundice, feeding difficulties and episodes of colic that continued during early infancy. Additionally, there was slowing of growth and mild developmental delay. He underwent surgical repair for supravalvular aortic stenosis at 6 months of age...
March 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28428677/hypothyroidism-in-pediatric-population-bosnian-and-herzegovinian-situation
#17
Edo Hasanbegovic, Snijezana Hasanbegovic, Edin Begic
INTRODUCTION: Thyroid gland diseases in children are in second place by frequency among all endocrine disorders. When interpreting the results of the thyroid function assessment it should be taken into account the significant differences in the concentrations of TSH, thyroid hormones, thyroid binding proteins and calcitonin among children of different ages. GOAL: To present the age and sex structure of the patients diagnosed with hypothyroidism, evaluate diagnostic methods for making diagnosis, evaluation of etiology of hypothyroidism, with special review of the therapeutic modality...
February 2017: Medical Archives
https://www.readbyqxmd.com/read/28412200/three-year-follow-up-of-children-with-abnormal-newborn-screening-results-for-congenital-hypothyroidism
#18
Min-Jae Kang, Hye-Rim Chung, Yeon-Joung Oh, Young-Suk Shim, Seung Yang, Il-Tae Hwang
BACKGROUND: To analyze predictive factors suggesting transient congenital hypothyroidism (TCH) compared to permanent congenital hypothyroidism (PCH) or transient thyroid function test (TFT) abnormalities among children who had positive screening results at our centers over the past decade. METHODS: A retrospective chart review of 105 subjects who presented elevated TSH levels on a newborn screening test (NST) was done. TCH was defined when a trial-off therapy was successful, and PCH was defined when a trial failed or when the subject was kept on medication beyond 3 years of age...
March 27, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28407273/comorbidity-of-chronic-spontaneous-urticaria-and-autoimmune-thyroid-diseases-a-systematic-review
#19
REVIEW
P Kolkhir, M Metz, S Altrichter, M Maurer
Patients with chronic spontaneous urticaria (CSU) are widely held to often have other autoimmune disorders, including autoimmune thyroid disease. Here, we systematically evaluated the literature on the prevalence of thyroid autoimmunity in CSU and vice versa. There is a strong link between CSU and elevated levels of IgG antithyroid autoantibodies (AAbs), with most of a large number of studies reporting rates of ≥10%. Levels of IgG against thyroid peroxidase (TPO) are more often elevated in CSU than those of other IgG antithyroid AAbs (strong evidence)...
April 13, 2017: Allergy
https://www.readbyqxmd.com/read/28397663/-a-rare-type-of-severe-obesity-in-children-and-adolescents
#20
Sara Østergaard Christensen, Kirsten Holm, Hanne Buciek Hove
A four-year-old girl was referred to a paediatric department with low height, obesity and hypothyroidism. Her paraclinical tests were characteristic with elevated P-parathyroid hormone concentration, hypothyroidism, growth hormone deficiency, abnormal phenotype with brachydactyly, tooth problems and mental retardation, which led to a suspicion of Albright's hereditary osteodystrophy (AHO). The diagnosis was verified by molecular genetic testing. Less than 1% of children with obesity have an endocrine disorder, and AHO is one of them...
February 20, 2017: Ugeskrift for Laeger
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