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Lisa C Barry, Laura Hatchman, Zhaoyan Fan, Jack M Guralnik, Robert X Gao, George A Kuchel
OBJECTIVES: To evaluate the feasibility, acceptability, and validity of a radio-frequency identification (RFID)-based system to measure gait speed in a clinical setting as a first step to using unobtrusive gait speed assessment in routine clinical care. DESIGN: Feasibility study comparing gait speed assessed using an RFID-based system with gait speed assessed using handheld stopwatch, the criterion standard. SETTING: Outpatient geriatrics clinic at a Connecticut-based academic medical center...
February 23, 2018: Journal of the American Geriatrics Society
Hossein Babaei, Elgar Enamzadeh
BACKGROUND: Polidocanol is approved for its competence in treatment of varicose veins and spider veins; however, unfortunately, many of its off-label uses are still underappreciated. OBJECTIVE: Lack of an appropriate comprehensive review for off-label uses of this medication troubles physicians about making evidence-based decisions on prescribing it for its various outstanding off-label uses. This article attempts to provide physicians with the latest information concerning successful and unsuccessful use of polidocanol as an alternative treatment for esophageal and gastric varices, tendinopathy and epicondylitis, vascular malformations, varicocele, hydrocele and spermatocele, aneurysmal bone cysts, itching, management of gastrointestinal bleeding, simple renal cysts, reducing the incidence and severity of radio-induced dermatitis, and hemorrhoids...
February 23, 2018: Current Clinical Pharmacology
Shengfeng Lu, Yuexia Tang, Yajuan Ding, Meiling Yu, Shuping Fu, Bingmei Zhu
OBJECTIVE: To explore the impact of electroacupuncture (EA) on the protein expression of adenosine receptors in the heart of the rats with myocardial ischemia (MI). METHODS: Thirty healthy male SD rats were divided randomly into a control group ( n =6), a model group ( n =12) and an EA group ( n =12). We ligated the left anterior descending artery (LAD) for MI model in the model group and EA group, and exposed the heart after opening the chest without ligation in the control group...
February 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Nicholas Ojile, Donna Sweet, K James Kallail
Introduction: Attitudes of individuals who provide HIV care towards prescribing Preexposure Prophylaxis (PrEP) to at-risk populations have been studied, but few studies indicate if family physicians would be willing to prescribe PrEP as most family physicians do not specialize in HIV medicine. Few data exist on the perceived barriers preventing family physicians from prescribing PrEP. The purpose of this project was to assess the attitudes and perceived barriers of family physicians in Kansas towards prescribing PrEP to high risk patient populations...
May 2017: Kansas Journal of Medicine
Mark W Hamm, Samuel V Calabrese, Scott J Knoer, Ashley M Duty
PURPOSE: The development of a Web-based program to track and manage emergency medications with radio frequency identification (RFID) is described. SUMMARY: At the Cleveland Clinic, medication kit restocking records and dispense locations were historically documented using a paper record-keeping system. The Cleveland Clinic investigated options to replace the paper-based tracking logs with a Web-based program that could track the real-time location and inventory of emergency medication kits...
March 1, 2018: American Journal of Health-system Pharmacy: AJHP
Brian James Francica, Ali Ghasemzadeh, Anthony L Desbien, Debebe Theodros, Kelsey E Sivick, Gabrielle L Reiner, Laura Hix Glickman, Ariel E Marciscano, Andrew B Sharabi, Meredith L Leong, Sarah M McWhirter, Thomas W Dubensky, Drew M Pardoll, Charles G Drake
The cGAS-STING cytosolic DNA sensing pathway may play an integral role in the initiation of antitumor immune responses. Studies evaluating the immunogenicity of various cyclic dinucleotide (CDN) STING agonists administered by intratumoral (IT) injection showed potent induction of inflammation, tumor necrosis, and in some cases, durable tumor-specific adaptive immunity. However, the specific immune mechanisms underlying these responses remain incompletely defined. The majority of these studies have focused on the effect of CDNs on immune cells but have not conclusively interrogated the role of stromal cells in the acute rejection of the CDN-injected tumor...
February 22, 2018: Cancer Immunology Research
Christine Atuhairwe, Dinah Amongin, Elly Agaba, Steven Mugarura, Ivan M Taremwa
BACKGROUND: Breast cancer, the third most frequent cancer of women is preventable through knowledge on breast self-examination. Of the 44% of women diagnosed with breast cancer at the Uganda Cancer Institute, only 22% go for check-up in less than three months. This study explored the effect of breast cancer knowledge on the uptake of breast cancer prevention modalities among women in Kyadondo County, Uganda. METHODS: A household survey of women in Kyadondo County was conducted during June, 2014 to August, 2015...
February 23, 2018: BMC Public Health
Rupali J Limaye, Amanda Berman, Jane Brown, Triza Kakhobwe
Concurrent sexual partnerships have been identified as a potential driver in the HIV epidemic in Southern Africa. This study utilised an innovative approach to explore perceptions of why Malawians may engage in these relationships, and their suggestions for reducing the practice among a select population of radio listeners. Using radio listener feedback in the form of text messages, we analysed approximately 1 000 text messages sent by individuals who listened to a reality radio programme that included real stories, told by Malawians, on topics related to HIV/AIDS...
February 22, 2018: African Journal of AIDS Research: AJAR
Wenting Dang, Libu Manjakkal, William Taube Navaraj, Leandro Lorenzelli, Vincenzo Vinciguerra, Ravinder Dahiya
Sensor-laden wearable systems that are capable of providing continuous measurement of key physiological parameters coupled with data storage, drug delivery and feedback therapy have attracted huge interest. Here we report a stretchable wireless system for sweat pH monitoring, which is able to withstand up to 53% uniaxial strain and more than 500 cycles to 30% strain. The stretchability of the pH sensor patch is provided by a pair of serpentine-shaped stretchable interconnects. The pH sensing electrode is made of graphite-polyurethane composite, which is suitable for biosensor application...
February 10, 2018: Biosensors & Bioelectronics
Daria Stypinski, Stephen A McQuarrie, Alexander J B McEwan, Leonard I Wiebe
The objective of this work is to evaluate the potential effect of cardiac stress exercise on the accumulation of [123 I]IAZA, a radiopharmaceutical used to image focal tissue hypoxia, in otherwise normal myocardium in healthy volunteers, and to determine the impact of exercise on [123 I]IAZA pharmacokinetics. The underlying goal is to establish a rational basis and a baseline for studies of focal myocardial hypoxia in cardiac patients using [123 I]IAZA. Three healthy male volunteers ran the 'Bruce' treadmill protocol, a clinically-accepted protocol designed to expose myocardial ischemia in patients...
February 22, 2018: Pharmaceutics
Amihay Nevo, Ronen Holland, Eran Schreter, Ron Gilad, Jack Baniel, Aenov Cohen, David Lifshitz
OBJECTIVES: To determine the accuracy of the surgeon's impression as to the stone free rate at the end of percutaneous nephrolithotomy (PNL), and to evaluate predictors for inaccurate estimation. MATERIALS AND METHODS: A prospective study conducted between 2010 and 2015. Surgeon's impression, categorized as "insignificant Residual fragments (RF)" (<4 mm) or "significant RF" (> 4mm), was recorder at the end of PNL, and was compared with postoperative imaging results, using CT or a combination of US and KUB for radiolucent and radio-opaque stones, respectively...
February 21, 2018: Journal of Endourology
Sumito Yoshida, Hiroaki Shime, Yohei Takeda, Jin-Min Nam, Ken Takashima, Misako Matsumoto, Hiroki Shirato, Masanori Kasahara, Tsukasa Seya
Radiotherapy induces anti-tumor immunity by induction of tumor antigens and damage-associated molecular patterns (DAMPs). DNA, a representative DAMP in radiotherapy, activates the STING pathway which enhances the immune response. However, the immune response does not always parallel the inflammation associated with radiotherapy. This lack of correspondence may in part explain the radiation-resistance of tumors. Additive immunotherapy is expected to revive tumor-specific CTLs facilitating radiation-resistant tumor shrinkage...
February 21, 2018: Cancer Science
Jinghua Li, Xiangyang Zu, Gaofeng Liang, KeKe Zhang, Yuliang Liu, Ke Li, Zhong Luo, Kaiyong Cai
Heavy atom nanoparticles have high X-ray absorption capacity and near infrared (NIR) photothermal conversion efficiency, which could be used as radio-sensitizers. We hypothesized that concave PtCu octopod nanoframes (OPCNs) would be an efficient nanoplatform for synergistic radio-photothermal tumor ablation. Methods: In this study, we newly exploited a folic acid-receptor (FR) mediated photothermal radiotherapy nanoagent base on OPCNs. OPCNs were synthesized with a hydrothermal method and then modified with polyethylene glycol (PEG) and folic acid (FA)...
2018: Theranostics
Eliezer Be'eri, Simon Owen, Maurit Beeri, Scott R Millis, Arik Eisenkraft
OBJECTIVES: Chemical-biological-radio-nuclear (CBRN) gas masks are the standard means for protecting the general population from inhalation of toxic industrial compounds (TICs), for example after industrial accidents or terrorist attacks. However, such gas masks would not protect patients on home mechanical ventilation, as ventilator airflow would bypass the CBRN filter. We therefore evaluated in vivo the safety of adding a standard-issue CBRN filter to the air-outflow port of a home ventilator, as a method for providing TIC protection to such patients...
February 21, 2018: Disaster Medicine and Public Health Preparedness
Chang Jin Lim, Min Gyu Park, Min Su Kim, Jeong Hwa Han, Soohaeng Cho, Mann-Ho Cho, Yeonjin Yi, Hyunbok Lee, Sang Wan Cho
The interfacial electronic structures of a bilayer of fullerene (C60 ) and zinc phthalocyanine (ZnPc) grown on vanadium pentoxide (V₂O₅) thin films deposited using radio frequency sputtering under various conditions were studied using X-ray and ultraviolet photoelectron spectroscopy. The energy difference between the highest occupied molecular orbital (HOMO) level of the ZnPc layer and the lowest unoccupied molecular orbital (LUMO) level of the C60 layer was determined and compared with that grown on an indium tin oxide (ITO) substrate...
February 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Paola Cappello, Claudia Curcio, Giorgia Mandili, Cecilia Roux, Sara Bulfamante, Francesco Novelli
Pancreatic Ductal Adenocarcinoma (PDA) is an almost incurable radio- and chemo-resistant tumor, and its microenvironment is characterized by a strong desmoplastic reaction associated with a significant infiltration of T regulatory lymphocytes and myeloid-derived suppressor cells (Tregs, MDSC). Investigating immunological targets has identified a number of metabolic and cytoskeletal related molecules, which are typically recognized by circulating antibodies. Among these molecules we have investigated alpha-enolase (ENO1), a glycolytic enzyme that also acts a plasminogen receptor...
February 16, 2018: Cancers
Suresh Subramanian, K V Vimalnath, Ashutosh Dash
Hepatocellular carcinoma (HCC) or liver cancer is an increasingly prevalent and highly morbid disease with critical significance in the Asian and African sub-continents. Among the various therapies currently employed in the clinic to combat the global menace of HCC, radio-embolization with suitable therapeutic isotopes is an effective targeted approach. In the Indian context, the significant cost and logistical disadvantage of imported radio-embolic formulations for HCC therapy make it essential to develop more feasible indigenous alternatives - using locally available radioisotopes and microspheric carriers - that can serve the nuclear medicine community...
February 20, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
R Flore, M A Zocco, M E Ainora, C Fonnesu, A Nesci, A Gasbarrini, F R Ponziani
OBJECTIVE: To quantify non-coronary vascular calcifications (VC) in asymptomatic patients at low-intermediate cardiovascular risk by a new color Doppler ultrasound (DUS)-based score (the carotid, aortic, lower limbs calcium score, CALCs), and to correlate this score with classical parameters associated with cardiovascular risk [carotid intima media thickness (IMT), and arterial stiffness (AS)]. PATIENTS AND METHODS: All consecutive asymptomatic patients who underwent a screening DUS of non-coronary circulation were evaluated and patients at low-intermediate cardiovascular risk were selected according to Framingham risk score (FRS)...
February 2018: European Review for Medical and Pharmacological Sciences
Friedrich-Alexander Ludwig, Steffen Fischer, René Smits, Winnie Deuther-Conrad, Alexander Hoepping, Solveig Tiepolt, Marianne Patt, Osama Sabri, Peter Brust
Both (+)-[18 F]flubatine and its enantiomer (-)-[18 F]flubatine are radioligands for the neuroimaging of α4β2 nicotinic acetylcholine receptors (nAChRs) by positron emission tomography (PET). In a clinical study in patients with early Alzheimer's disease, (+)-[18 F]flubatine ((+)-[18 F] 1 ) was examined regarding its metabolic fate, in particular by identification of degradation products detected in plasma and urine. The investigations included an in vivo study of (+)-flubatine ((+)- 1 ) in pigs and structural elucidation of formed metabolites by LC-MS/MS...
February 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Min-Ho Seo, Jae-Hyeon Ko, Jeong Oen Lee, Seung-Deok Ko, Jeong Hun Mun, Byung Jin Cho, Yong-Hyun Kim, Jun-Bo Yoon
Micro/nano-electromechanical (M/NEM) switches have received significant attention as promising switching devices for a wide range of applications such as computing, radio-frequency communication, and power gating devices. However, M/NEM switches still suffer from unacceptably low reliability because of irreversible degradation at the contacting interfaces, hindering adoption in practical applications and further development. Here, we evaluate and verify graphene as a contact material for reliability-enhanced M/NEM switching devices...
February 20, 2018: ACS Applied Materials & Interfaces
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