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https://www.readbyqxmd.com/read/29231149/radiopharmaceuticals-labelled-with-copper-radionuclides-clinical-results-in-human-beings
#1
Giulia Anna Follacchio, Maria Silvia De Feo, Francesco Monteleone, Giuseppe De Vincentis, Mauro Liberatore
Positron emission tomography (PET) is an instrumental diagnostic modality based on the representation (by images or numeric parameters) of the spatial and temporal distribution of molecules labelled with positron-emitting radionuclides. PET makes it possible to study biochemical processes underlying the function of several organs, providing information otherwise achievable only with bioptic assessment. PET has been developed around the positron-emitting radioisotopes of biologically important elements such as carbon, oxygen and nitrogen (11C, 15O, 13N), which enable PET imaging to identify the biodistribution of a wide range of small molecules...
December 11, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29230164/a-sub-millimeter-inductively-powered-neural-stimulator
#2
Daniel K Freeman, Jonathan M O'Brien, Parshant Kumar, Brian Daniels, Reed A Irion, Louis Shraytah, Brett K Ingersoll, Andrew P Magyar, Andrew Czarnecki, Jesse Wheeler, Jonathan R Coppeta, Michael P Abban, Ronald Gatzke, Shelley I Fried, Seung Woo Lee, Amy E Duwel, Jonathan J Bernstein, Alik S Widge, Ana Hernandez-Reynoso, Aswini Kanneganti, Mario I Romero-Ortega, Stuart F Cogan
Wireless neural stimulators are being developed to address problems associated with traditional lead-based implants. However, designing wireless stimulators on the sub-millimeter scale (<1 mm3) is challenging. As device size shrinks, it becomes difficult to deliver sufficient wireless power to operate the device. Here, we present a sub-millimeter, inductively powered neural stimulator consisting only of a coil to receive power, a capacitor to tune the resonant frequency of the receiver, and a diode to rectify the radio-frequency signal to produce neural excitation...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29229685/the-essential-role-of-phospho-t38-cpi-17-in-the-maintenance-of-physiological-blood-pressure-using-genetically-modified-mice
#3
Qunhui Yang, Wataru Fujii, Noriyuki Kaji, Shigeru Kakuta, Kodai Kada, Masayoshi Kuwahara, Hirokazu Tsubone, Hiroshi Ozaki, Masatoshi Hori
PKC-potentiated phosphorylation-dependent inhibitory protein of protein phosphatase 1 (CPI-17), an endogenous myosin phosphatase inhibitory protein, is considered a key molecule for Ca2+ sensitization of the contractile apparatus. Here, we have used clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 to generate CPI-17-deficient [knockout (KO)] and threonine 38 (T38)-phospho-resistant mice [Threonine mutant into Alanine (TA)], and then effects of CPI-17 on vascular contractility in vitro and mean blood pressure (MBP) in vivo were investigated...
December 11, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29229651/in-situ-measurements-of-saturn-s-ionosphere-show-that-it-is-dynamic-and-interacts-with-the-rings
#4
J-E Wahlund, M W Morooka, L Z Hadid, A M Persoon, W M Farrell, D A Gurnett, G Hospodarsky, W S Kurth, S-Y Ye, D J Andrews, N J T Edberg, A I Eriksson, E Vigren
The ionized upper layer of Saturn's atmosphere, its ionosphere, provides a closure of currents mediated by the magnetic field to other electrically charged regions (e.g., rings) and hosts ion - molecule chemistry. In 2017, the Cassini spacecraft passed inside the planet's rings, allowing in situ measurements of the ionosphere. The Radio and Plasma Wave Science (RPWS) instrument detected a cold, dense and dynamic ionosphere at Saturn that interacts with the rings. Plasma densities reached up to 1000 cm-3 and electron temperatures were below 1160 K near closest approach...
December 11, 2017: Science
https://www.readbyqxmd.com/read/29229364/pathology-and-management-of-masses-in-the-accessory-parotid-gland-region-24-year-experience-at-a-single-institution
#5
Hailong Ma, Shufang Jin, Zhong Du, Lizhen Wang, Zhiyuan Zhang, Yan'an Wang
PURPOSE: Masses in the accessory parotid gland (APG) region are clinically rare and their management can lead to conflicts between the need for tumor resection and facial cosmesis. The aim of this study was to analyze the pathological classifications and management of APG lesions in our hospital. MATERIALS AND METHODS: From January 1993 to March 2017, 130 patients with primary tumors in the APG region who underwent surgical treatment were enrolled. Follow-up surveys after surgery were then carried out...
November 17, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29228626/boosting-the-effects-of-hyperthermia-based-anticancer-treatments-by-hsp90-inhibition
#6
Lianne E M Vriend, Nathalie van den Tempel, Arlene L Oei, Mike L'Acosta, Frederique J Pieterson, Nicolaas A P Franken, Roland Kanaar, Przemek M Krawczyk
Hyperthermia - application of supra-physiological temperatures to cells, tissues or organs - is a pleiotropic treatment that affects most aspects of cellular metabolism, but its effects on DNA are of special interest in the context of cancer research and treatment. Hyperthermia inhibits repair of various DNA lesions, including double-strand breaks (DSBs), making it a powerful radio- and chemosensitizer, with proven clinical efficacy in therapy of various types of cancer, including tumors of head and neck, bladder, breast and cervix...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228563/riluzole-a-potential-therapeutic-intervention-in-human-brain-tumor-stem-like-cells
#7
Swetlana Sperling, Thiha Aung, Sabine Martin, Veit Rohde, Milena Ninkovic
A small subpopulation of tumor stem-like cells has the capacity to initiate tumors and mediate radio- and chemoresistance in diverse cancers hence also in glioblastoma (GBM). It has been reported that this capacity of tumor initiation in the brain is mainly dependent on the body's nutrient supply. This population of so-called brain tumor initiating or brain tumor stem-like cells (BTSCs) is able to extract nutrients like glucose with a higher affinity. Riluzole, a drug approved for treating amyotrophic lateral sclerosis (ALS), was reported to possess anticancer properties, affecting the glutamate metabolism...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227548/resistance-of-oral-cancer-cells-to-5-ala-mediated-photodynamic-therapy
#8
Flávia Cristina Perillo Rosin, Marina Gabriela Teixeira, Cibele Pelissari, Luciana Corrêa
Photodynamic therapy (PDT) has been indicated for oral squamous cell carcinoma (OSCC) at early stages. Chemo and radio-resistance are frequently observed in OSCC, but it is unknown whether this tumor can develop resistance to PDT. It was investigated the process of acquiring resistance to multiple cycles of PDT by using OSCC cells. We also analyzed the expression of anti-apoptotic proteins and those related to Akt/mTOR pathway. Sub-lethal doses of PDT were applied, consisting of a constant concentration of 5-aminolevulinic acid (5-ALA) (1 mM, 4-hour incubation) and increasing irradiation dose with LED (from 5...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29226973/metal-citrate-complex-transport-in-kineococcus-radiotolerans
#9
Brian P Huta, Nigel H Miller, Eleanor L Robertson, Robert P Doyle
The growth of an organism is highly dependent on the acquisition of carbon and metals, and availability of these nutrients in the environment affects its survival. Organisms can obtain both nutrients simultaneously through proteins of the CitMHS superfamily. Bioinformatic studies suggested a CitMHS gene (Accession number ABS03965.1) in Kineococcus radiotolerans. Radio flux assays following 14-C radiolabelled citrate, either free or complexed to a variety of metal ions, in K. radiotolerans demonstrated internalization of the citrate when bound to select metal ions only, primarily in the form of calcium-citrate...
December 11, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29226464/place-of-death-in-the-snowy-monaro-region-of-new-south-wales-a-study-of-residents-who-died-of-a-condition-amenable-to-palliative-care
#10
Suzanne Rainsford, Nicholas J Glasgow, Rod D MacLeod, Teresa Neeman, Christine B Phillips, Robert B Wiles
OBJECTIVE: To describe the place of death of residents in a rural region of New South Wales. DESIGN: Cross-sectional quantitative study using death data collected from local funeral directors (in person and websites), residential aged-care facilities, one multipurpose heath service and obituary notices in the local media (newspapers/radio). SETTING: Snowy Monaro region (NSW Australia). PARTICIPANTS: Residents, with advanced frailty or one of 10 conditions amenable to palliative care, who died between 1 February 2015 and 31 May 2016...
December 11, 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29226125/stattic-enhances-radiosensitivity-and-reduces-radio-induced-migration-and-invasion-in-hcc-cell-lines-through-an-apoptosis-pathway
#11
Gang Xu, Lihua Zhu, Yan Wang, Yawei Shi, Aihua Gong, Chaoyang Wu
Purpose: Signal transducer and activator of transcription factor 3 (STAT3) is involved in tumorigenesis, development, and radioresistance of many solid tumors. The aim of this study is to investigate the effects of stattic (an inhibitor of STAT3) on the radiosensitivity and radio-induced migration and invasion ability in hepatocellular carcinoma (HCC) cell lines. Methods: HCC cells were treated with stattic, and cell survival rate was analyzed through CCK-8 assay...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29224769/evaluation-of-speech-reception-threshold-in-noise-in-young-cochlear%C3%A2-nucleus%C3%A2-system-6-implant-recipients-using-two-different-digital-remote-microphone-technologies-and-a-speech-enhancement-sound-processing-algorithm
#12
Sergio Razza, Monica Zaccone, Aannalisa Meli, Eliana Cristofari
OBJECTIVE: Children affected by hearing loss can experience difficulties in challenging and noisy environments even when deafness is corrected by Cochlear implant (CI) devices. These patients have a selective attention deficit in multiple listening conditions. At present, the most effective ways to improve the performance of speech recognition in noise consists of providing CI processors with noise reduction algorithms and of providing patients with bilateral CIs. The aim of this study was to compare speech performances in noise, across increasing noise levels, in CI recipients using two kinds of wireless remote-microphone radio systems that use digital radio frequency transmission: the Roger Inspiro accessory and the Cochlear Wireless Mini Microphone accessory...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29223016/application-of-single-nucleotide-extension-and-maldi-tof-mass-spectrometry-in-proofreading-and-dna-repair-assay
#13
Kang-Yi Su, Hung-Ming Lai, Steven D Goodman, Wei-Yao Hu, Wern-Cherng Cheng, Liang-In Lin, Ya-Chien Yang, Woei-Horng Fang
Proofreading and DNA repair are important factors in maintaining the high fidelity of genetic information during DNA replication. Herein, we designed a non-labeled and non-radio-isotopic simple method to measure proofreading. An oligonucleotide primer is annealed to a template DNA forming a mismatched site and is proofread by Klenow fragment of Escherichia coli DNA polymerase I (pol I) in the presence of all four dideoxyribonucleotide triphosphates. The proofreading excision products and re-synthesis products of single nucleotide extension are subjected to MALDI-TOF mass spectrometry (MS)...
December 2, 2017: DNA Repair
https://www.readbyqxmd.com/read/29222785/neuronal-cell-morphology-in-primary-cerebellar-granule-cells-using-high-content-analysis
#14
Nicholas Radio, Steven Frank
Neurite outgrowth, one of the underlying cellular processes that defines the development and functionality of the mammalian nervous system, is also a sensitive indicator of neuronal cell health. From screening libraries of putative neurotherapeutic compounds to analyzing the millions of environmental pollutants for which we have inadequate neurotoxicity safety data, the large volume of chemical compounds that require evaluation is a major obstacle for manual imaging and analysis methods. In this context, high-content analysis (HCA) has emerged as a sensitive and accurate method for detecting changes in neuronal cell morphology within a format applicable to screening large chemical libraries...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222678/dose-responses-for-mortality-from-cerebrovascular-and-heart-diseases-in-atomic-bomb-survivors-1950-2003
#15
Helmut Schöllnberger, Markus Eidemüller, Harry M Cullings, Cristoforo Simonetto, Frauke Neff, Jan Christian Kaiser
The scientific community faces important discussions on the validity of the linear no-threshold (LNT) model for radiation-associated cardiovascular diseases at low and moderate doses. In the present study, mortalities from cerebrovascular diseases (CeVD) and heart diseases from the latest data on atomic bomb survivors were analyzed. The analysis was performed with several radio-biologically motivated linear and nonlinear dose-response models. For each detrimental health outcome one set of models was identified that all fitted the data about equally well...
December 8, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29222422/reconfigurable-yagi-uda-antenna-based-on-a-silicon-reflector-with-a-solid-state-plasma
#16
Da-Jin Kim, Jang-Soon Park, Cheol Ho Kim, Jae Hur, Choong-Ki Kim, Young-Kyun Cho, Jun-Bong Ko, Bonghyuk Park, Dongho Kim, Yang-Kyu Choi
This paper describes the fabrication and characterization of a reconfigurable Yagi-Uda antenna based on a silicon reflector with a solid-state plasma. The silicon reflector, composed of serially connected p-i-n diodes, forms a highly dense solid-state plasma by injecting electrons and holes into the intrinsic region. When this plasma silicon reflector is turned on, the front-realized gain of the antenna increases by more than 2 dBi beyond 5.3 GHz. To achieve the large gain increment, the structure of the antenna is carefully designed with the aid of semiconductor device simulation and antenna simulation...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221951/role-of-drugs-in-the-prevention-and-amelioration-of-radiation-induced-toxic-effects
#17
REVIEW
Rakesh Raman Patyar, Sazal Patyar
As the use of radiation technology for nuclear warfare or for the benefits of mankind (e.g. in radiotherapy or radio-diagnosis) is increasing tremendously, the risk of associated side effects is becoming a cause of concern. These effects, ranging from nausea/vomiting to death, may result from accidental or deliberate exposure and begin in seconds. Through this review paper, efforts have been done to critically review different compounds which have been investigated as radioprotectors and radiation mitigators...
December 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29221663/-long-term-outcomes-of-prostate-cancer-patients-with-lymph-nodes-metastasis-after-radical-prostatectomy-and-pelvic-lymph-node-dissection
#18
S De Vergie, N Gaschignard, M Baron, J Branchereau, F Luyckx, T Butel, M-A Perrouin-Verbe, O Bouchot, J Rigaud
INTRODUCTION: The aim of this study was to evaluate biochemical recurrence-free survival (RFS) and to identify useful predictors of such survival in localized prostate cancer patients (cN0) and pelvic lymph node metastasis (pN+) treated with radical prostatectomy and pelvic lymph node dissection. PATIENTS AND METHODS: This multicenter and retrospective study, assessed overall survival (OS), cancer specific survival (CSS) and biochemical recurrence-free survival (RFS), between January 2005 until December 2010 with 5 years of distance...
December 5, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/29221170/proteoglycan-targeting-applied-to-hypoxia-activated-prodrug-therapy-in-chondrosarcoma-first-proof-of-concept
#19
Aurélien Voissiere, Valérie Weber, Yvain Gerard, Françoise Rédini, Florian Raes, Jean-Michel Chezal, Françoise Degoul, Caroline Peyrode, Elisabeth Miot-Noirault
Due to its abundant chondrogenic matrix and hypoxic tissue, chondrosarcoma is chemo- and radio-resistant. Our group has developed a proteoglycan targeting strategy by using a quaternary ammonium (QA) function as a carrier of DNA alkylating agents to chondrosarcoma environment. Here, we assessed the relevance of this strategy applied to hypoxia-activated prodrugs, by conjugating a QA to 2-nitroimidazole phosphoramidate. This derivative, named as 8-QA, was evaluated respectively to its non-QA equivalent and to a QA-conjugated but non-hypoxia activated...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29219389/mode-matching-for-optical-antennas
#20
Thorsten Feichtner, Silke Christiansen, Bert Hecht
The emission rate of a point dipole can be strongly increased in the presence of a well-designed optical antenna. Yet, optical antenna design is largely based on radio-frequency rules, ignoring, e.g., Ohmic losses and non-negligible field penetration in metals at optical frequencies. Here, we combine reciprocity and Poynting's theorem to derive a set of optical-frequency antenna design rules for benchmarking and optimizing the performance of optical antennas driven by single quantum emitters. Based on these findings a novel plasmonic cavity antenna design is presented exhibiting a considerably improved performance compared to a reference two-wire antenna...
November 24, 2017: Physical Review Letters
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