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bladder outlet obstruction

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https://www.readbyqxmd.com/read/28638819/testosterone-modifies-alterations-to-detrusor-muscle-after-partial-bladder-outlet-obstruction-in-juvenile-mice
#1
Andrew S Flum, Paula R Firmiss, Diana K Bowen, Natalie Kukulka, Grace B Delos Santos, Robert W Dettman, Edward M Gong
Lower urinary tract symptoms secondary to posterior urethral valves (PUV) arise in boys during adolescence. The reasons for this have previously been attributed to increased urine output as boys experience increased growth. Additionally, there are few choices for clinicians to effectively treat these complications. We formed the new hypothesis that increased androgen levels at this time of childhood development could play a role at the cellular level in obstructed bladders. To test this hypothesis, we investigated the role of testosterone on bladder detrusor muscle following injury from partial bladder outlet obstruction (PO) in mice...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28637788/the-effects-of-neuromodulation-in-a-novel-obese-prone-rat-model-of-detrusor-underactivity
#2
Eric J Gonzalez, Warren M Grill
Obesity is a global epidemic associated with an increased risk for lower urinary tract dysfunction. Inefficient voiding and urinary retention may arise in late-stage obesity when the expulsive force of the detrusor smooth muscle cannot overcome outlet resistance. Detrusor underactivity (DUA) and impaired contractility may contribute to the pathogenesis of non-obstructive urinary retention. We used cystometry and electrical stimulation of peripheral nerves (pudendal and pelvic n.) to characterize and improve bladder function in urethane-anesthetized obese-prone (OP) and obese-resistant (OR) rats following diet-induced obesity (DIO)...
June 21, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28631830/overactive-bladder-symptoms-after-midurethral-sling-surgery-in-women-risk-factors-and-management
#3
Tom Marcelissen, Philip Van Kerrebroeck
INTRODUCTION: Overactive bladder syndrome (OAB) including urgency and urgency urinary incontinence (UUI) occurs frequently after stress urinary incontinence (SUI) surgery. It is important to identify the risk factors for the occurrence of OAB symptoms in order to adequately inform the patient before surgery. Furthermore, when facing OAB after sling surgery it is crucial to know how to manage these symptoms. METHODS: We conducted a literature review in order to assess the risk factors and management of OAB symptoms after SUI surgery...
June 20, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28624526/postoperative-urinary-retention-is-an-independent-predictor-of-short-and-long-term-future-bladder-outlet-procedure-in-men
#4
Robert H Blackwell, Srikanth Vedachalam, Arpeet S Shah, Anai N Kothari, Paul C Kuo, Gopal N Gupta, Thomas M T Turk
PURPOSE: Postoperative urinary retention (POUR) is a common complication across surgical specialties. To date, no literature has examined postoperative urinary retention as a predictor of long-term receipt of surgery for bladder outlet obstruction. MATERIALS AND METHODS: A retrospective review of inpatient, non-urologic surgery patients in California between 2008-2010 was performed. POUR during the index admission was identified, as was the receipt of a bladder outlet procedure (BOP: transurethral resection of prostate, photoselective vaporization of prostate, suprapubic prostatectomy) on a subsequent encounter...
June 14, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28600735/an-adolescent-boy-progressing-insidiously-to-end-stage-renal-disease-questions
#5
Aysun Çaltık Yılmaz, Bahar Buyukkaragoz, Selcuk Kivilcim, Aslı Celebi Tayfur, Sacit Gunbey
Hinman syndrome (HS), or non-neurogenic neurogenic bladder, is a voiding dysfunction of the bladder of neuropsychological origin that is characterized by functional bladder outlet obstruction in the absence of neurologic deficits. The bladder-sphincter discoordination causes damage to the bladder and upper urinary tract if it is not timely diagnosed and adequately treated. This case emphasizes the following important message; nighttime wetting is not a benign condition in every child. Parental awareness should be raised about voiding disorders, so it may be possible to prevent some important renal diseases such as Hinman syndrome...
June 9, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28593170/increased-detrusor-collagen-is-associated-with-detrusor-overactivity-and-decreased-bladder-compliance-in-men-with-benign-prostatic-obstruction
#6
Carlos H S Bellucci, Wesley de O Ribeiro, Thiago S Hemerly, José de Bessa, Alberto A Antunes, Katia R M Leite, Homero Bruschini, Miguel Srougi, Cristiano M Gomes
BACKGROUND: This study aimed to investigate the relationship between detrusor collagen content and urodynamic parameters in men with benign prostatic obstruction. MATERIAL AND METHODS: Nineteen consecutive patients undergoing open prostatectomy for bladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH) were evaluated. Urodynamic tests were performed in all patients. BOO and detrusor contractility were assessed with the BOO index (BOOI) and the bladder contractility index (BCI), respectively...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28592436/bladder-fibrosis-during-outlet-obstruction-is-triggered-through-the-nlrp3-inflammasome-and-the-production-of-il-1%C3%AE
#7
Francis Monty Hughes, Stephanie J Sexton, Huixia Jin, Vihasa Govada, J Todd Purves
Bladder outlet obstruction (BOO) triggers inflammation in the bladder through the NLRP3 inflammasome. BOO also activates fibrosis, which is largely responsible for the decompensation of the bladder in the chronic state. Because fibrosis can be driven by inflammation, we have explored a role for NLRP3 (and IL-1β produced by NLRP3) in the activation and progression of BOO-induced fibrosis. Female rats were divided into 5 groups: 1) control, 2) sham, 3) BOO + Vehicle, 4) BOO + the NLRP3 inhibitor glyburide or 5) BOO + the IL-1β receptor antagonist anakinra...
June 7, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28567099/a-chinese-medicine-formula-xian-jia-tang-for-treating-bladder-outlet-obstruction-by-improving-urodynamics-and-inhibiting-oxidative-stress-through-potassium-channels
#8
Jie Sun, Wei Shen, Wenjin An, Qiufen Li, Shunan Qiu, Shaobo Jiang
The aim of this study is to investigate efficacy of a traditional Chinese medicine formula (named Xian-Jia-Tang, XJT) on bladder outlet obstruction (BOO) in rats and explore its mechanisms. Total 80 BOO model rats were established and randomly divided into 4 groups: physiological saline, XJT, Cesium Chloride (CC), and XJT and CC groups. Meanwhile, 12 rats were used as normal control. Bladder weight and urodynamics were measured. Oxidative stress level and mRNA expressions of potassium channels gene were detected in detrusor...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28546038/-pathophysiology-of-detrusor-underactivity-in-the-elderly
#9
J Kerdraon, B Peyronnet, X Gamé, B Fatton, R Haddad, C Hentzen, C Jeandel, P Mares, M Mezzadri, A-C Petit, G Robain, J-M Vetel, G Amarenco
AIM: The aim of this study was to review the evidence regarding the pathophysiology of detrusor underactivity in the elderly. METHODS: A literature review was conducted in July 2016 using the Medline/Pubmed database limiting the search to works in English or French. RESULTS: The prevalence of detrusor underactivity has been reported to range from 8% to 48% depending on the definition used and the age of the population studied. Current data suggest that aging may itself be a causative factor of detrusor underactivity through myogenic dysfunctions (ultrastructural degeneration of the detrusor muscle) and neurogenic dysfunctions (by degeneration of efferent but mostly afferent innervation mechanisms)...
May 22, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28538709/minimal-invasive-cystometry-and-intra-abdominal-pressure-assessments-in-rodents-a-novel-animal-study
#10
Yafei Yang, Jin Yang, Lin Chen, Jianyun Hu, Shasha Xing, Bastian Amend, Arnulf Stenzl, Xin Wei, Haifeng Hu
BACKGROUND The abdominal straining pattern can act as a novel parameter for improving the prediction of bladder outlet obstruction (BOO). To preserve detrusor function in the early stage of urinary system impairment, such as BOO, we establish a novel method for cystometry and Intra-abdominal pressure (IAP) assessments in rodents without cystostomy. MATERIAL AND METHODS Twenty mice and rats were divided into three groups (control, sham-operated and BOO group) respectively. The cystometry and IAP assessments were measured by the pediatric venous indwelling sheath and coronary dilatation catheter connected to Laborie urodynamic system on postoperative day 7...
May 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28536217/caution-advised-with-dapagliflozin-in-the-setting-of-male-urinary-tract-outlet-obstruction
#11
Victoria Hall, Jason Kwong, Douglas Johnson, Elif Ilhan Ekinci
We describe an adverse outcome in a 70-year-old man with type 2 diabetes mellitus treated with sodium-glucose cotransporter type 2 (SGLT2) inhibitor dapagliflozin. SGLT2 inhibitors act in the proximal tubules to prevent glucose reabsorption and induce urinary glucose excretion, they have been associated with increased risk of urinary tract infection (UTI). Our patient presented to hospital with Escherichia coli septicaemia with positive urine and blood cultures on the background of two previous UTIs occurring post commencement of dapagliflozin in the community...
May 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28518071/nerve-sparing-mid-urethral-obstruction-nemo-in-female-small-rodents
#12
Martin Sidler, Karen J Aitken, Jia Xin Jiang, Darius J Bägli
Partial bladder outlet obstruction (pBOO) has a high prevalence, causes significant patient burden, and immense health care costs. The most common animal model to investigate bladder remodeling in pBOO are female rodents undergoing partial obstruction at the proximal urethra. Variability in the degree of obstruction and animal mortality are major concerns with proximal obstruction. Furthermore, dissecting around the proximal urethra and bladder neck jeopardizes bladder innervation. We developed a nerve-sparing mid-urethral obstruction (NeMO) model for pBOO avoiding the disadvantages of the traditional model...
April 25, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28506859/the-obstructed-bladder-expression-of-collagen-matrix-metalloproteinases-muscarinic-receptors-and-angiogenic-and-neurotrophic-factors-in-patients-with-benign-prostatic-hyperplasia
#13
João Arthur Brunhara Alves Barbosa, Sabrina T Reis, Marco Nunes, Yuri A Ferreira, Katia R Leite, William C Nahas, Miguel Srougi, Alberto A Antunes
OBJECTIVE: To evaluate the gene expression of collagen, matrix metalloproteinases (MMPs) and inhibitors, cholinergic muscarinic receptors (CHRMs), and angiogenic and nerve growth factors (NGFs) in the bladder of patients with bladder outlet obstruction caused by benign prostatic hyperplasia (BPH). METHODS: We analyzed bladder specimens from 43 patients with obstructive BPH undergoing transurethral resection of the prostate as compared to 10 age-matched controls with an International Prostatic Symptom Score of <8 and a prostate volume of <30 g...
May 12, 2017: Urology
https://www.readbyqxmd.com/read/28499730/effects-of-withdrawing-alpha-1-blocker-from-the-combination-therapy-with-alpha-1-blocker-and-5-alpha-reductase-inhibitor-in-patients-with-lower-urinary-tract-symptoms-suggestive-of-benign-prostatic-hyperplasia-a-prospective-and-comparative-trial-using-urodynamics
#14
Yoshihisa Matsukawa, Shun Takai, Yasuhito Funahashi, Tsuyoshi Majima, Masashi Kato, Tokunori Yamamoto, Momokazu Gotoh
PURPOSE: To compare the effects on lower urinary tract symptoms (LUTS) and bladder outlet obstruction between combination therapy with α1 blocker and 5α-reductase inhibitor and a switch to 5α-reductase inhibitor monotherapy, and determine the factors influencing changes in LUTS after α1 blocker withdrawal. MATERIALS AND METHODS: One-hundred and forty outpatients with LUTS suggestive of benign prostatic hyperplasia received combination therapy with silodosin 8 mg/day and dutasteride 0...
May 9, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28476482/report-on-the-society-for-fetal-urology-panel-discussion-on-the-selection-criteria-and-intervention-for-fetal-bladder-outlet-obstruction
#15
M K Farrugia, M C Braun, C A Peters, R Ruano, C D Herndon
INTRODUCTION: The Society for Fetal Urology panel section at the 2016 Fall Congress featured a multidisciplinary discussion on appropriate patient selection, the conservative versus surgical management, and postnatal renal outcome of fetuses with lower urinary tract obstruction (LUTO). SELECTION CRITERIA FOR INTERVENTION: Rodrigo Ruano shared his experience of prenatal intervention, presenting the outcome of 111 fetuses with severe LUTO treated with vesicoamniotic shunting (VAS) (n = 16), cystoscopy (n = 34) or no intervention (n = 61) in a non-randomized series...
March 24, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28462670/transurethral-enucleation-with-bipolar-for-benign-prostatic-hyperplasia-2-year-outcomes-and-the-learning-curve-of-a-single-surgeon-s-experience-of-603-consecutive-patients
#16
Yosuke Hirasawa, Yuji Kato, Kiichiro Fujita
BACKGROUND: To investigate perioperative outcomes, the learning curve, and 2-year follow-up after transurethral enucleation with bipolar (TUEB) for patients with benign prostatic hyperplasia (BPH). METHODS: From December 2011 to October 2016, 603 consecutive patients underwent TUEB for BPH, performed by a single surgeon. Patients were preoperatively assessed by using the International Prostate Symptom Score (IPSS), quality-of-life score (QOLs), serum prostate-specific antigen (PSA), and uroflowmetry evaluation...
May 25, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28446011/development-of-decision-support-formulas-for-the-prediction-of-bladder-outlet-obstruction-and-prostatic-surgery-in-patients-with-lower-urinary-tract-symptom-benign-prostatic-hyperplasia-part-ii-external-validation-and-usability-testing-of-a-smartphone-app
#17
Min Soo Choo, Seong Jin Jeong, Sung Yong Cho, Changwon Yoo, Chang Wook Jeong, Ja Hyeon Ku, Seung-June Oh
PURPOSE: We aimed to externally validate the prediction model we developed for having bladder outlet obstruction (BOO) and requiring prostatic surgery using 2 independent data sets from tertiary referral centers, and also aimed to validate a mobile app for using this model through usability testing. METHODS: Formulas and nomograms predicting whether a subject has BOO and needs prostatic surgery were validated with an external validation cohort from Seoul National University Bundang Hospital and Seoul Metropolitan Government-Seoul National University Boramae Medical Center between January 2004 and April 2015...
April 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28446010/development-of-decision-support-formulas-for-the-prediction-of-bladder-outlet-obstruction-and-prostatic-surgery-in-patients-with-lower-urinary-tract-symptom-benign-prostatic-hyperplasia-part-i-development-of-the-formula-and-its-internal-validation
#18
Min Soo Choo, Changwon Yoo, Sung Yong Cho, Seong Jin Jeong, Chang Wook Jeong, Ja Hyeon Ku, Seung-June Oh
PURPOSE: As the elderly population increases, a growing number of patients have lower urinary tract symptom (LUTS)/benign prostatic hyperplasia (BPH). The aim of this study was to develop decision support formulas and nomograms for the prediction of bladder outlet obstruction (BOO) and for BOO-related surgical decision-making, and to validate them in patients with LUTS/BPH. METHODS: Patient with LUTS/BPH between October 2004 and May 2014 were enrolled as a development cohort...
April 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28444709/male-bladder-outlet-obstruction-time-to-re-evaluate-the-definition-and-reconsider-our-diagnostic-pathway-ici-rs-2015
#19
REVIEW
Kevin Rademakers, Marcus J Drake, Andrew Gammie, Jens C Djurhuus, Peter F W M Rosier, Paul Abrams, Christopher Harding
The diagnosis of bladder outlet obstruction (BOO) in the male is dependent on measurements of pressure and flow made during urodynamic studies. The procedure of urodynamics and the indices used to delineate BOO are well standardized largely as a result of the work of the International Continence Society. The clinical utility of the diagnosis of BOO is however, less well defined and there are several shortcomings and gaps in the currently available medical literature. Consequently the International Consultation on Incontinence Research Society (ICI-RS) held a think tank session in 2015 entitled "Male bladder outlet obstruction: Time to re-evaluate the definition and reconsider our diagnostic pathway?" This manuscript details the discussions that took place within that think tank setting out the pros and cons of the current definition of BOO and exploring alternative clinical tests (alone or in combination) which may be useful in the future investigation of male patients with lower urinary tract symptoms...
April 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28436120/efficacy-of-holmium-laser-transurethral-incision-of-the-prostate-in-symptomatic-mild-to-moderate-benign-prostate-enlargement-based-on-preoperative-characteristics
#20
Yoon Seok Suh, Kwang Jin Ko, Tae Heon Kim, Hyun Hwan Sung, Kyu-Sung Lee
OBJECTIVE: To investigate the efficacy of Holmium laser transurethral incision of the prostate (Ho-TUIP) with preoperative characteristics based on urodynamic parameters. METHODS: The medical records of 40 consecutive cases of Ho-TUIP in patients unresponsive to medical treatment were retrospectively reviewed. The efficacy of Ho-TUIP was analyzed according to preoperative factors, including urodynamic parameters. Treatment success was confirmed if overall efficacy demonstrated an improvement that was "good or greater" according to the criteria developed by Homma et al...
April 23, 2017: Lower Urinary Tract Symptoms
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