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bladder outlet obstruction

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https://www.readbyqxmd.com/read/28315343/inhibition-of-agonist-induced-smooth-muscle-contraction-by-picotamide-in-the-male-human-lower-urinary-tract-outflow-region
#1
Martin Hennenberg, Alexander Tamalunas, Yiming Wang, Patrick Keller, Melanie Schott, Frank Strittmatter, Annika Herlemann, Qingfeng Yu, Beata Rutz, Anna Ciotkowska, Christian G Stief, Christian Gratzke
Male lower urinary tract symptoms (LUTS) due to bladder outlet obstruction are characterized by abnormal smooth muscle contractions in the lower urinary tract. Alpha1-adrenoceptor antagonists may induce smooth muscle relaxation in the outflow region and represent the current goldstandard of medical treatment. However, results may be unsatisfactory or inadequate. Apart from α1-adrenoceptor agonists, smooth muscle contraction in the outflow region may be induced by thromboxane A2 (TXA2), endothelins, or muscarinic receptor agonists...
March 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28314702/short-term-outcomes-of-the-multi-institutional-bladder-exstrophy-consortium-successes-and-complications-in-the-first-two-years-of-collaboration
#2
J G Borer, E Vasquez, D A Canning, J V Kryger, A Bellows, D Weiss, T Groth, A Shukla, M P Kurtz, M E Mitchell
INTRODUCTION/BACKGROUND: Bladder exstrophy is a rare diagnosis that presents major reconstructive challenges. To increase experience and proficiency in the care of bladder exstrophy (BE), the Multi-Institutional BE Consortium (MIBEC) was formed, with a focus on refining technical aspects of complete primary repair of bladder exstrophy (CPRE) and subsequent care. OBJECTIVE: Outcome measures included successful CPRE (absence of dehiscence), complications, and integrated points of technique and care over the short-term...
February 20, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28303850/incidence-and-risk-factors-of-de-novo-stress-urinary-incontinence-after-pelvic-floor-reconstruction-a-nested-case-control-study
#3
Shi-Yan Wang, Ting-Ting Cao, Run-Zhi Wang, Xin Yang, Xiu-Li Sun, Jian-Liu Wang
BACKGROUND: Some patients with pelvic organ prolapse may suffer from lower urinary tract symptoms (LUTS), especially stress urinary incontinence (SUI) named de novo SUI after pelvic floor reconstruction. This study aimed to investigate the incidence and risk factors of de novo SUI. METHODS: This is a nested case-control study of 533 patients who underwent pelvic floor reconstruction due to pelvic organ prolapse (POP) at the Department of Gynecology in Peking University People's Hospital from January 2011 to March 2013...
March 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28301527/associations-between-the-severity-of-obstructive-lower-urinary-tract-symptoms-and-care-seeking-behavior-in-rural-africa-a-cross-sectional-survey-from-uganda
#4
Lynn Stothers, Andrew J Macnab, Francis Bajunirwe, Sharif Mutabazi, Jonathan Berkowitz
STUDY TYPE: A cross sectional survey. BACKGROUND: Global estimates indicate that by 2018 2.3 billion individuals worldwide will suffer from lower urinary tract symptoms (LUTS), with 1.1 billion having LUTS related to bladder outlet obstruction (BOO). Left untreated BOO in men causes irreversible changes to the urinary tract leading to urinary retention, the need for catheterization, renal failure and even death. Estimates suggest that Africa will be one of the continents with the greatest increase in (LUTS) by 2018 however direct measures in Africa are lacking...
2017: PloS One
https://www.readbyqxmd.com/read/28298357/how-important-is-the-%C3%AE-1-adrenoceptor-in-primate-and-rodent-proximal-urethra-sex-differences-in-the-contribution-of-%C3%AE-1-adrenoceptor-to-urethral-contractility
#5
Eduardo C Alexandre, Mariana G de Oliveira, Rafael Campos, Luiz Ricardo A Kiguti, Fabiano B Calmasini, Fábio H Silva, Andrew D Grant, Naoki Yoshimura, Edson Antunes
Urethral smooth muscle (USM) contributes to urinary continence by contracting during the urine storage phase, which is mainly mediated by activation of post-junctional α1-adrenoceptors. Males and females show differences in the functioning of the lower urinary tract and the most common urinary tract symptoms (LUTS). LUTS in men typically occur in association with bladder outlet obstruction, whereas in women urinary urge-incontinence symptoms are more common. Therefore, this study aimed to evaluate sex differences in α1-adrenoceptor subtype expression and their importance in proximal urethra contraction in mouse (C57BL6/J) and marmoset (Callithrix jacchus)...
March 15, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28289208/specific-deletion-of-lkb1-stk11-in-the-m%C3%A3-llerian-duct-mesenchyme-drives-hyperplasia-of-the-periurethral-stroma-and-tumorigenesis-in-male-mice
#6
Jitu W George, Amanda L Patterson, Pradeep S Tanwar, André Kajdacsy-Balla, Gail S Prins, Jose M Teixeira
Nearly all older men will experience lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH), the etiology of which is not well understood. We have generated Stk11(CKO) mice by conditional deletion of the liver kinase B1 (LKB1) tumor suppressor gene, Stk11 (serine threonine kinase 11), in the fetal Müllerian duct mesenchyme (MDM), the caudal remnant of which is thought to be assimilated by the urogenital sinus primordial mesenchyme in males during fetal development. We show that MDM cells contribute to the postnatal stromal cells at the dorsal aspect of the prostatic urethra by lineage tracing...
March 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28285351/cavin-3-prkcdbp-deficiency-reduces-the-density-of-caveolae-in-smooth-muscle
#7
Baoyi Zhu, Karl Swärd, Mari Ekman, Bengt Uvelius, Catarina Rippe
Cavins belong to a family of proteins that contribute to the formation of caveolae, which are membrane organelles with functional roles in muscle and fat. Here, we investigate the effect of cavin-3 ablation on vascular and urinary bladder structure and function. Arteries and urinary bladders from mice lacking cavin-3 (knockout: KO) and from controls (wild type: WT) were examined. Our studies revealed that the loss of cavin-3 resulted in ∼40% reduction of the caveolae protein cavin-1 in vascular and bladder smooth muscle...
March 11, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28267055/overactive-bladder-syndrome-and-lower-urinary-tract-symptoms-after-prostate-cancer-treatment
#8
Suzanne Biers, Karl-Dietrich Sievert, Nikesh Thiruchelvam
PURPOSE OF REVIEW: To assess the contemporary literature on the prevalence, cause and management of lower urinary tract symptoms (LUTS) and bladder overactivity following treatment of prostate cancer with radical surgery, radiotherapy and minimally invasive therapies for localized prostate cancer, including cryotherapy and high-intensity focused ultrasound (HIFU). RECENT FINDINGS: Generally, the highest risk of urinary incontinence is after open radical prostatectomy (7-40%), although not all contemporary studies demonstrate a difference between open and laparoscopic techniques...
March 4, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28266820/surgical-treatment-of-detrusor-underactivity-a-short-term-proof-of-concept-study
#9
Jerry G Blaivas, James C Forde, Jonathan L Davila, Lucas Policastro, Michael Tyler, Joshua Aizen, Anand Badri, Rajveer S Purohit, Jeffrey P Weiss
OBJECTIVES: To compare the surgical outcomes of men with bladder outlet obstruction (BOO) due to benign prostatic obstruction (BPO) to those with detrusor underactivity (DU) or acontractile detrusor (DA). MATERIALS AND METHODS: This retrospective, IRB approved study included men who underwent BPO surgery for refractory LUTS or urinary retention. Patients were grouped based on videourodynamic (VUDS) findings: 1) men with BOO, 2) men with DU and 3) men with DA. The primary outcome measure was the Patient Global Impression of Improvement (PGII)...
March 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28266818/update-on-complications-of-synthetic-suburethral-slings
#10
Cristiano Mendes Gomes, Fabrício Leite Carvalho, Carlos Henrique Suzuki Bellucci, Thiago Souto Hemerly, Fábio Baracat, Jose de Bessa, Miguel Srougi, Homero Bruschini
Synthetic suburethral slings have become the most widely used technique for the surgical treatment of stress urinary incontinence. Despite its high success rates, significant complications have been reported including bleeding, urethral or bladder injury, urethral or bladder mesh erosion, intestinal perforation, vaginal extrusion of mesh, urinary tract infection, pain, urinary urgency and bladder outlet obstruction. Recent warnings from important regulatory agencies worldwide concerning safety issues of the use of mesh for urogynecological reconstruction have had a strong impact on patients as well as surgeons and manufacturers...
March 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28265592/multiple-uric-acid-bladder-stones-clinical-presentation-and-endoscopic-management
#11
Fabio Cesar Miranda Torricelli, Shih-Chieh Jeff Chueh, Shujane Shen, Manoj Monga
Background: Bladder urinary calculi occur in 3%-8% of men with bladder outlet obstruction, and although most of them are composed of calcium, in a few cases uric acid bladder stones are diagnosed. Case Presentation: We present clinical images and therapeutic management of a 65-year-old diabetic man with significant prostate enlargement and >30 bladder stones, the largest being 17 mm. Despite the large stone burden, the patient was managed by cystolithotripsy. Remarkably, stone composition analysis revealed 100% uric acid stone...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/28265323/bladder-and-bowel-dysfunction-in-children-an-update-on-the-diagnosis-and-treatment-of-a-common-but-underdiagnosed-pediatric-problem
#12
REVIEW
Joana Dos Santos, Roberto I Lopes, Martin A Koyle
Bladder and bowel dysfunction (BBD) describes a spectrum of lower urinary symptoms (LUTS) accompanied by fecal elimination issues that manifest primarily by constipation and/or encopresis. This increasingly common entity is a potential cause of significant physical and psychosocial burden for children and families. BBD is commonly associated with vesicoureteral reflux (VUR) and recurrent urinary tract infections (UTIs), which at its extreme may lead to renal scarring and kidney failure. Additionally, BBD is frequently seen in children diagnosed with behavioural and neuropsychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD)...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28263050/clinical-significance-of-intravesical-prostatic-protrusion-in-the-management-of-benign-prostatic-enlargement-a-systematic-review-and-critical-analysis-of-current-evidence
#13
Malte Rieken, Fabrizio Presicce, Riccardo Autorino, Cosimo De Nunzio
INTRODUCTION: Filling cystometry and pressure flow studies (PFS) are the most widespread used invasive urodynamic techniques in the assessment of male LUTS. However, these techniques are time- and cost-intensive. Intravesical prostatic protrusion (IPP) has been proposed as non-invasive method used to diagnose bladder outlet obstruction (BOO) in men with male lower urinary tract symptoms (LUTS). The purpose of the present review is to analyze the diagnostic and therapeutic relevance of IPP...
March 6, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28261619/the-long-term-effect-of-radical-prostatectomy-on-erectile-function-urinary-continence-and-lower-urinary-tract-symptoms-a-comparison-to-age-matched-healthy-controls
#14
Badereddin Mohamad Al-Ali, Anton Ponholzer, Herbert Augustin, Stephan Madersbacher, Karl Pummer
Introduction. To analyze the impact of radical prostatectomy (RPE) on erectile function and lower urinary tract function in comparison to age-matched healthy men. Materials and Methods. Patients who underwent radical retropubic prostatectomy completed questionnaires containing the IIEF-5, the Bristol female LUTS questionnaire, and the International Prostate Symptom Score (IPSS). Results. Patients after RPE were included (n = 363). Age-matched healthy men (n = 363) were included. The mean IIEF-5 of patients aged 61-70 yrs after RPE was 10...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28256466/evaluation-of-the-effects-of-omega-3-interferon-alpha-2b-administration-on-partial-bladder-outlet-obstruction-in-a-rat-model
#15
Fatih Firat, Nihat Uluocak, Fikret Erdemir, Dogan Atilgan, Fatma Markoc, Bekir Suha Parlaktas, Adem Yasar
BACKGROUND & OBJECTIVES: In bladder outlet obstruction-induced rat models, the transforming growth factor-beta (TGF-β) and collagen ratios have been shown to be increased. Increased TGF-β leads to fibrosis. In this study, the effect of omega-3 and interferon alpha-2b (IFN α-2b) was investigated on oxidative stress, inflammation and fibrosis in bladder structure in a partial bladder outlet obstruction (PBOO) rat model. METHODS: A total of 35 male Wistar albino rats, weighing 300-350 g, were used in the study...
October 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28255867/benign-prostatic-obstruction-relief-in-patients-with-lower-urinary-tract-symptoms-suggestive-of-benign-prostatic-enlargement-undergoing-endoscopic-surgical-procedures-or-therapy-with-alpha-blockers-a-review-of-urodynamic-studies
#16
REVIEW
Ferdinando Fusco, Massimiliano Creta, Vittorio Imperatore, Nicola Longo, Ciro Imbimbo, Herbert Lepor, Vincenzo Mirone
Benign prostatic obstruction (BPO) contributes to the genesis of lower urinary tract symptoms as well as to pathologic remodeling of the lower and upper urinary tract in patients with benign prostate enlargement. Urodynamic studies demonstrate that both medical therapy with alpha-blockers (ABs) and endoscopic surgical procedures provide BPO relief. However, the magnitude of improvement is higher after surgery. Among ABs, silodosin is associated with the highest improvement of bladder outlet obstruction index (BOOI)...
March 2, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28254232/comparing-the-midterm-outcome-of-single-incision-vaginal-mesh-and-transobturator-vaginal-mesh-in-treating-severe-pelvic-organ-prolapse
#17
Tsai-Hwa Yang, Ling-Ying Wu, Fei-Chi Chuang, Fu-Tsai Kung, Kuan-Hui Huang
OBJECTIVE: The aim of this study is to compare perioperative parameters and midterm clinical outcomes using two different mesh kits: transobturator vaginal mesh (TVM) (both Perigee and Apogee), versus single incision vaginal mesh (SIM) (combined Elevate anterior/apical system and Elevate posterior/apical system) in treating severe pelvic organ prolapse (POP). MATERIALS AND METHODS: This is a retrospective cohort study. During 2008 and 2013, those women with severe POP [POP quantification system (POP-Q), Stage III and Stage IV], who received either TVM or SIM operation, were enrolled for cohort comparison...
February 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28241023/diagnostic-value-of-urodynamic-bladder-outlet-obstruction-to-select-patients-for-transurethral-surgery-of-the-prostate-systematic-review-and-meta-analysis
#18
Myong Kim, Chang Wook Jeong, Seung-June Oh
PURPOSE: To investigate the diagnostic value of urodynamic bladder outlet obstruction (BOO) in the selection of patients for transurethral surgery of the prostate. MATERIALS AND METHODS: We systematically searched online PubMed, Embase, and Cochrane Library databases from January 1989 to June 2014. RESULTS: A total of 19 articles met the eligibility criteria for this systematic review. The eligible studies included a total of 2321 patients with a median number of 92 patients per study (range: 12-437)...
2017: PloS One
https://www.readbyqxmd.com/read/28220532/diagnosing-bladder-outlet-obstruction-using-the-penile-cuff-test-in-men-with-lower-urinary-tract-symptoms
#19
Kwang Jin Ko, Yoon Seok Suh, Tae Heon Kim, Hyun Hwan Sung, Gyu Ha Ryu, Kyu-Sung Lee
AIM: The current standard diagnostic test to evaluate bladder outlet obstruction (BOO) is pressure-flow study (PFS). The penile cuff test (PCT) was introduced as a non-invasive alternative to PFS to determine the isovolumetric bladder pressure and also flow rate. The aim of the study was to evaluate the diagnostic accuracy and acceptability of the PCT, compared to those of PFS, in the assessment of BOO in men. METHODS: A total of 146 consecutive men with an International Prostate Symptom Score (IPSS) >12 and lower urinary tract symptoms (LUTS) for >6 months were included in this single-institution, prospective, diagnostic study...
February 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28213857/management-of-overactive-bladder-in-the-face-of-high-grade-prolapse
#20
REVIEW
Juan Guzman-Negron, Sandip Vasavada
Patients with pelvic organ prolapse (POP) may present with a large combination of symptoms including overactive bladder (OAB) symptoms such as urgency, frequency, and urgency incontinence. The explanation as to why these symptoms are more prevalent in POP patients is not clearly understood, but there seems to be an overall agreement that prolapse-induced bladder outlet obstruction (BOO) may trigger bladder changes resulting in OAB symptoms. Presuming this to be true, many of the studies managing OAB in POP patients have focused on the surgical management of prolapse and its aftermath, which in many of the patients leads to improvement of OAB symptoms...
February 2017: Current Urology Reports
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