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https://www.readbyqxmd.com/read/29671672/pathophysiological-effect-of-bladder-outlet-obstruction-on-the-urothelium
#1
Grzegorz Niemczyk, Katarzyna Czarzasta, Piotr Radziszewski, Paweł Włodarski, Agnieszka Cudnoch-Jędrzejewska
Bladder outlet obstruction (BOO) and associated lower urinary tract symptoms are major urological issues that significantly affect patient's quality of life and may lead to severe complications. The prevalence of both is increasing each year, raising the burden to health system. Therefore, casual and symptomatic treatment should be of great importance. However, management of symptoms is often difficult as their pathophysiology is multifactorial and not well elucidated. Recently urothelium has gathered much attention as one of the potential causal agents...
April 19, 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29665998/lower-urinary-tract-symptoms-including-bladder-outlet-obstruction-what-s-new-in-diagnostics
#2
REVIEW
Stavros Gravas, Iason Kyriazis, Adam P Klausner
It is well known that lower urinary tract symptoms (LUTS) have a multifactorial etiology. Therefore, there is an increased need for improved diagnostics for the optimal assessment of patients with LUTS in order to identify the various causes of symptoms and improve disease phenotyping. Research has focused on the development of improved urodynamic technologies and the development of noninvasive tests that could replace urodynamic studies. This mini-review will present the most recently published studies on the topic including new technologies in the diagnosis of bladder outlet obstruction, novel metrics for bladder sensation, analysis of filling phase rhythm, measurement of detrusor wall tension, and brain imaging during urodynamic studies...
April 14, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29664124/a-comparison-of-the-treatment-recommendations-for-neurogenic-lower-urinary-tract-dysfunction-in-the-national-institute-for-health-and-care-excellence-european-association-of-urology-and-international-consultations-on-incontinence-guidelines
#3
Ashley Jaggi, Marcus Drake, Emad Siddiqui, Francis Fatoye
AIMS: Healthcare guidelines are an important vehicle in establishing up-to-date evidence based medicine (EBM) in clinical practice. Due to varying development processes, clinical guidelines created by different institutions can often contain contrasting recommendations. This can have implications for optimal and standardized patient care across management settings. METHODS: The similarities and differences of treatment recommendations made in the National Institute for Health and Care Excellence (NICE), The European Association of Urology (EAU), and the International Consultation on Continence (ICI) guidelines for neurogenic lower urinary tract dysfunction (NLUTD) were assessed...
April 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29627154/how-to-close-classic-bladder-exstrophy-are-subspecialty-training-and-technique-important
#4
Brian M Inouye, J Todd Purves, Jonathan C Routh, Mahir Maruf, Daniel Friedlander, John Jayman, John P Gearhart
INTRODUCTION: Successful primary closure is one of the main factors for achieving continence in a classic bladder exstrophy (CBE) patient. Even with contemporary management, patients still have failed primary closures. We sought to understand the role of training, surgical technique, and their impacts on outcomes of CBE closure. MATERIALS AND METHODS: A retrospective cohort study from the largest single-institution database of primary and re-closure CBE patients in the world was performed...
March 29, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29617077/robotic-adenomectomy-using-a-laparoscopic-dissector
#5
Lessandro Curcio Gonçalves, Felipe Monnerat Lott, Rafael Rosa
INTRODUCTION: Only few reports are known about the use of robotic surgery for prostate benign enlargement. The robotic surgery can be improved by laparoscopic tricks. We show a video of robotic adenomectomy where a laparoscopic dissector is used to help create the plan between prostatic capsule and adenoma. MATERIALS AND METHODS: A 62 years old male had severe urinary flow outlet obstruction. Medical therapy was not effective. Ultrasound detected a 92gr enlarged prostate with a large middle lobe...
March 15, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29609420/efficacy-of-an-alpha-blocker-for-the-treatment-of-nonneurogenic-voiding-dysfunction-in-women-an-8-week-randomized-double-blind-placebo-controlled-trial
#6
Young-Suk Lee, Kyu-Sung Lee, Myung-Soo Choo, Joon Chul Kim, Jeong Gu Lee, Ju Tae Seo, Jeong Zoo Lee, Ji Youl Lee, Seung-June Oh, Yong Gil Na
PURPOSE: To evaluate the efficacy of an alpha-1 adrenergic receptor (α1-AR) blocker for the treatment of female voiding dysfunction (FVD) through a pressure-flow study. METHODS: This was a randomized, double-blind, placebo-controlled trial. Women aged ≥18 years with voiding symptoms, as defined by an American Urological Association symptom score (AUA-SS) ≥15 and a maximum flow rate (Qmax) <15 mL/sec with a voided volume of >100 mL and/or a postvoid residual (PVR) volume >150 mL, were randomly allocated to either the alfuzosin or placebo group...
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29608020/prostatic-stromal-inflammation-is-associated-with-bladder-outlet-obstruction-in-patients-with-benign-prostatic-hyperplasia
#7
So Inamura, Hideaki Ito, Tomochika Shinagawa, Manami Tsutsumiuchi, Minekatsu Taga, Motohiro Kobayashi, Osamu Yokoyama
BACKGROUND: Benign prostatic hyperplasia (BPH) is a common urologic disease in older men. Prostatic inflammation research has focused on the magnitude of inflammation; its location has received little attention. We investigated whether the anatomic location of prostatic inflammation is related to the severity of lower urinary tract symptoms (LUTS), measured subjectively and objectively. METHODS: We retrospectively analyzed hematoxylin+eosin-stained tissue specimens from 179 BPH patients who underwent transurethral resection of the prostate (TURP) or holmium laser enucleation of the prostate (HoLEP)...
April 2, 2018: Prostate
https://www.readbyqxmd.com/read/29606553/new-and-emerging-technologies-in-treatment-of-lower-urinary-tract-symptoms-from-benign-prostatic-hyperplasia
#8
REVIEW
Nikhil K Gupta, Steven N Gange, Kevin T McVary
INTRODUCTION: Lower urinary tract symptoms (LUTS) from bladder outlet obstruction from benign prostatic hyperplasia (BPH) occur in a large percentage of urologic patients. Treatment of this condition with medical and surgical therapy provides symptom relief but has serious adverse effects and causes sexual dysfunction. New technologies to treat BPH-associated LUTS aim to effectively treat urinary symptoms and minimize side effects and sexual dysfunction. AIM: To review the efficacy of new and emerging therapies for treatment of LUTS from BPH...
March 29, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29603912/photoselective-vaporization-of-the-prostate-with-the-180-w-xps-greenlight-laser-five-year-experience-of-safety-efficiency-and-functional-outcomes
#9
Khaled Ajib, Mila Mansour, Marc Zanaty, Mansour Alnazari, Pierre-Alain Hueber, Malek Meskawi, Roger Valdivieso, Come Tholomier, Benjamin Pradere, Vincent Misrai, Dean Elterman, Kevin C Zorn
INTRODUCTION: Transurethral resection of the prostate (TURP) is still considered the gold standard surgical treatment for symptomatic benign prostatic hyperplasia (BPH). However, photoselective vaporization of the prostate (PVP) has gained widespread global acceptance in national guidelines as a safe and effective alternative option. Nevertheless, further evidence is required to assess the durability of Greenlight PVP. Herein, we reported our five years PVP experience with the Greenlight 180W XPS laser system...
March 19, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29603785/alpha-1-adrenergic-antagonists-5-alpha-reductase-inhibitors-phosphodiesterase-type-5-inhibitors-and-phytotherapic-compounds-in-men-with-lower-urinary-tract-symptoms-suggestive-of-benign-prostatic-obstruction-a-systematic-review-and-meta-analysis-of-urodynamic
#10
REVIEW
Ferdinando Fusco, Massimiliano Creta, Cosimo De Nunzio, Mauro Gacci, Vincenzo Li Marzi, Enrico Finazzi Agrò
AIMS: To perform a systematic review and meta-analysis of studies evaluating the urodynamic outcomes of alpha-1 adrenergic antagonists (ABs), 5-alpha reductase inhibitors (5-ARIs), phosphodiesterase type 5 inhibitors (PDE5is), and phytotherapic compounds in patients with lower urinary tract symptoms related to benign prostatic obstruction (LUTS/BPO). METHODS: A systematic review of PubMed/Medline, ISI Web of Knowledge, and Scopus databases was performed in June 2017...
March 31, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29595043/minimally-invasive-approach-for-the-management-of-urological-complications-after-renal-transplantation-single-center-experience
#11
Orkunt Özkaptan, Cuneyd Sevinc, Muhsin Balaban, Tahir Karadeniz
BACKROUND: The aim of the study was to characterise urological complications after renal transplantation and to evaluate the role of minimally invasive management for urological complications. METHODS: A total of 920 kidney transplantations were performed between 2008 and 2015. All patients were followed up for at least 1 year after transplantation. Complications regarded as urological were urinary leakage, ureteral stricture, urinary malignancy, bladder outlet obstruction (BOO) and urinary calculi...
March 28, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29593464/the-emerging-role-of-inflammasomes-as-central-mediators-in-inflammatory-bladder-pathology
#12
REVIEW
Brian M Inouye, Francis M Hughes, Stephanie J Sexton, J Todd Purves
Irritative voiding symptoms (e.g. increased frequency and urgency) occur in many common pathologic conditions such as urinary tract infections and bladder outlet obstruction, and these conditions are well-established to have underlying inflammation that directly triggers these symptoms. However, it remains unclear as to how such diverse stimuli individually generate a common inflammatory process. Jürg Tschopp provided substantial insight into this conundrum when, working with extracts from THP-1 cells, he reported the existence of the inflammasome...
February 2018: Current Urology
https://www.readbyqxmd.com/read/29574791/inhibition-of-human-prostate-smooth-muscle-contraction-by-the-lim-kinase-inhibitors-sr7826-and-limki3
#13
Qingfeng Yu, Christian Gratzke, Yiming Wang, Annika Herlemann, Christian Maximilian Sterr, Beata Rutz, Anna Ciotkowska, Xialong Wang, Frank Strittmatter, Christian G Stief, Martin Hennenberg
BACKGROUND AND PURPOSE: In men with benign prostatic hyperplasia, increased smooth muscle tone in the prostate may lead to bladder outlet obstruction and subsequent lower urinary tract symptoms. Consequently, medical treatment aims to inhibit prostate smooth muscle contraction. However, the efficacy of available treatment options is limited, and improved understanding of mechanisms of prostate smooth muscle contraction and identification of new targets for medical intervention are mandatory...
March 25, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29572181/urinary-bladder-organ-hypertrophy-is-partially-regulated-by-akt1-mediated-protein-synthesis-pathway
#14
Li-Ya Qiao, Chunmei Xia, Shanwei Shen, Seong Ho Lee, Paul H Ratz, Matthew O Fraser, Amy Miner, John E Speich, Jeffrey J Lysiak, William D Steers
AIMS: The present study aims to investigate the role of Akt in the regulation of urinary bladder organ hypertrophy caused by partial bladder outlet obstruction (pBOO). MAIN METHODS: Male rats were surgically induced for pBOO. Real-time PCR and western blot were used to examine the levels of mRNA and protein. A phosphoinositide 3-kinase (PI3K) inhibitor LY294002 was used to inhibit the activity of endogenous Akt. KEY FINDINGS: The urinary bladder developed hypertrophy at 2 weeks of pBOO...
March 20, 2018: Life Sciences
https://www.readbyqxmd.com/read/29568661/congenital-bladder-diverticulum-in-adults-a-case-report-and-review-of-the-literature
#15
Rawad Abou Zahr, Khalil Chalhoub, Farah Ollaik, Joe Nohra
A 37-year-old male patient presented to the emergency department with fever, gross hematuria, and irritative lower urinary tract symptoms. Investigations revealed the presence of a large left bladder diverticulum superior and lateral to the left ureteral orifice without bladder outlet obstruction. Bladder diverticula in adults almost always present in the setting of bladder outlet obstruction. The finding of a congenital bladder diverticulum in an adult represents a rare clinical entity.
2018: Case Reports in Urology
https://www.readbyqxmd.com/read/29566360/the-antimuscarinic-agent-tolterodine-regulates-bladder-extracellular-matrix-in-partial-bladder-outlet-obstruction-in-rats
#16
Tong-Xin Yang, De-Yi Luo, Yi-Fei Lin, Qiang Liu, Xiang Cai, Jian-Zhong Ai, Hong Li, Hong Shen, Kun-Jie Wang
BACKGROUND/AIMS: Antimuscarinic agents can delay the progression of bladder dysfunction caused by bladder outlet obstruction (BOO). To date, the relationship between muscarinic receptor activity and the bladder extracellular matrix (ECM) remains unclear. Thus, an animal model of partial BOO (PBOO) in female rats was established to explore the variation in bladder wall ECM proteins under PBOO conditions with antimuscarinic agent administration. METHODS: Rats were randomly divided into three groups: sham, PBOO, and PBOO plus tolterodine...
March 20, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29551557/surgical-management-of-anatomic-bladder-outlet-obstruction-in-males-with-neurogenic-bladder-dysfunction-a-systematic-review
#17
REVIEW
Toscane C Noordhoff, Jan Groen, Jeroen R Scheepe, Bertil F M Blok
CONTEXT: Surgical treatment of anatomic bladder outlet obstruction (BOO) may be indicated in males with neurogenic bladder dysfunction. A bothersome complication after surgery is urinary incontinence. OBJECTIVE: To identify the optimal practice in the surgical treatment of anatomic BOO in males with neurogenic bladder dysfunction, due to multiple sclerosis, Parkinson disease, spinal cord injury (SCI), spina bifida, or cerebrovascular accident (CVA). EVIDENCE ACQUISITION: A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement...
March 15, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29543065/day-case-holmium-laser-enucleation-of-the-prostate-feasibility-safety-and-predictive-factors
#18
S-M Lee, K Gordon, R McMillan, F Crystal, P Acher
Introduction Transurethral resection of the prostate has remained the most common operation for bladder outlet obstruction in the UK, but it is associated with potential morbidity and median two-day length of hospital stay. Holmium laser enucleation of the prostate (HoLEP) provides an alternative procedure. Provision of day-case HoLEP would improve patient care through increased efficiency. We assessed the feasibility and safety of day-case HoLEP and examined predictive factors for increased length of hospital stay...
March 15, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29539922/re-female-bladder-outlet-obstruction-an-update-on-diagnosis-and-management
#19
Alan J Wein
No abstract text is available yet for this article.
May 2017: Journal of Urology
https://www.readbyqxmd.com/read/29526701/early-surgical-intervention-may-be-more-likely-to-cause-complications-in-patients-with-male-lower-urinary-tract-symptoms-than-to-prevent-them
#20
Marcus J Drake
There is no evidence that early surgical intervention will prevent complications due to bladder outlet obstruction, and a high likelihood that the surgery will bring its own complications.
March 8, 2018: European Urology Focus
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