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bladder outlet obstruction

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https://www.readbyqxmd.com/read/29221474/increased-expression-of-neuregulin-1-in-the-urothelium-of-rat-bladder-with-partial-bladder-outlet-obstruction
#1
Seung Woo Yang, Seong Woo Jeong, Ki Hak Song
BACKGROUND: This study determined whether changes in the expression of neuregulin (NRG) 1, erbB2 tyrosine kinase (ErbB2) and the M2 muscarinic receptor in the urothelium and detrusor muscle of the rat bladder were associated with partial bladder outlet obstruction (PBOO). METHODS: Male Sprague-Dawley rats (body weight 250-300 g) were used and subdivided into control (n = 10) and PBOO groups (n = 20). PBOO was induced for 21 days, and the expression of NRG1, ErbB2 and M2 muscarinic receptor mRNA and protein was evaluated using reverse transcriptase-polymerase chain reaction (RT-PCR) and western blotting, respectively...
December 8, 2017: BMC Urology
https://www.readbyqxmd.com/read/29211350/the-angiotensin-ii-receptors-type-1-blockage-affects-the-urinary-bladder-activity-in-hyperosmolar-induced-detrusor-overactivity-in-rats-preliminary-results
#2
Kajetan Juszczak, Piotr Maciukiewicz
BACKGROUND: Angiotensin II receptors play a role in the pathogenesis of urinary bladder dysfunction, especially in the case of bladder outlet obstruction. The function of these receptors in the detrusor overactivity (DO) still remains unclear. OBJECTIVES: The study aims to investigate some of the mechanisms through which hyperosmolarity induces urinary bladder overactivity. The effect of angiotensin II receptor type 1 - AT1 (telmisartan) on urinary bladder function in physiological state and in hyperosmolar-induced DO in rat model was explored...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29193884/morphological-and-clinical-evaluation-of-prostatic-urethra-using-modified-sonourethrography-with-retrograde-jelly-injection
#3
Tomonori Minagawa, Hironori Daimon, Noriyuki Ogawa, Tetsuichi Saito, Toshiro Suzuki, Takahisa Domen, Takashi Nagai, Teruyuki Ogawa, Osamu Ishizuka
OBJECTIVE: Using modified sonourethrography (mSUG) with retrograde jelly injection to precisely measure the morphological characteristics of the prostatic urethra, we assessed prostatic urethral morphology associated with clinical parameters of benign prostatic hyperplasia (BPH). METHODS: BPH patients (n = 43) and control patients with localized prostate cancer (PC; n = 57) were imaged by mSUG before surgery. Using the seminal colliculus as a landmark, prostatic urethral angulation (PUA), sagittal urethral diameter, and anterior or posterior prostatic urethral length were measured...
November 29, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29176315/protective-effects-of-antimuscarinics-on-the-bladder-remodeling-after-bladder-outlet-obstruction
#4
Qiang Liu, Deyi Luo, Tongxin Yang, Banghua Liao, Hong Li, Kun-Jie Wang
BACKGROUND/AIMS: Overactive bladder associated with bladder outlet obstruction (BOO) is a highly prevalent condition, which is usually treated with antimuscarinics. However, the potential effects of antimuscarinics on the structure and function of bladder have not been investigated thus far. METHODS: Sprague-Dawley(R) rats accepted bladder neck obstruction surgery or sham surgery, and then received treatment of three different antimuscarinics (Solifenacin, Darifenacin, and Tolterodine) or vehicle...
November 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29164680/effects-of-tadalafil-on-storage-and-voiding-function-in-patients-with-male-lower-urinary-tract-symptoms-suggestive-of-benign-prostatic-hyperplasia-a-urodynamic-based-study
#5
Yoshihisa Matsukawa, Tsuyoshi Majima, Kazuna Matsuo, Yasuhito Funahashi, Masashi Kato, Tokunori Yamamoto, Momokazu Gotoh
OBJECTIVE: To investigate the effects of tadalafil on storage and voiding function in treatment-naïve patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia, based on a urodynamic study. METHODS: This was an open-labeled, single-center, prospective study. A total of 80 untreated outpatients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia received tadalafil 5 mg/day for 12 weeks. Subjective symptoms and objective findings on voiding and storage function obtained through urodynamic studies, including cystometry and pressure flow study, were evaluated before and after treatment...
November 22, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29151006/the-practical-update-for-family-physicians-in-the-diagnosis-and-management-of-overactive-bladder-and-lower-urinary-tract-symptoms
#6
Jack Barkin, Jeffrey Habert, Amy Wong, Livia Y T Lee
OBJECTIVE: To provide family physicians with an up-to-date, practical overview of the diagnosis and management of overactive bladder (OAB) alone or with bladder outlet obstruction. MAIN MESSAGE: OAB is urinary urgency with or without incontinence, often accompanied by frequency and nocturia, in the absence of urinary tract infection and can affect both men and women. Men often have co-existing OAB associated with bladder outlet obstruction, and benign prostatic hyperplasia...
October 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29143172/identification-of-key-genes-and-construction-of-microrna-mrna-regulatory-networks-in-bladder-smooth-muscle-cell-response-to-mechanical-stimuli-using-microarray-expression-profiles-and-bioinformatics-analysis
#7
Liao Peng, De-Yi Luo
PURPOSE: To identify keys genes and elucidate miRNA-mRNA regulatory networks in Bladder smooth muscle cell (BSMC) response to mechanical stimuli. METHODS: Human BSMCs, seeded on a silicone membrane, were subjected to mechanical stretch or without stretch. Microarray was used to analyze the differential expression of mRNAs and miRNAs between human BSMCs under mechanical stretch and control static control group. Differentially expressed genes(DEGs) and miRNAs (DEMs) in these two groups were identified...
November 15, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29124245/thermo-expandable-prostatic-stents-for-bladder-outlet-obstruction-in-the-frail-and-elderly-population-an-underutilized-procedure
#8
Kapil Sethi, Michael Bozin, Tebogo Jabane, Richard McMullin, David Cook, Rob Forsyth, Lachlan Dodds, Lydia Johns Putra
Purpose: To report our outcomes with the use of a thermo-expandable metallic intraprostatic stent (Memokath) for patients with bladder outlet obstruction (BOO) secondary to prostatic obstruction, and to assess it is a feasible option for many frail and elderly men unsuitable for surgery. Materials and Methods: We reviewed patients who underwent insertion of a Memokath stent for BOO over 17 years (January 1999 to December 2015) at one regional center over a long follow-up period (median, 7 years)...
November 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29090339/holmium-laser-enucleation-of-the-prostate-is-an-effective-treatment-in-patients-with-concomitant-bladder-diverticula-and-outlet-obstruction
#9
Deepak K Agarwal, Amy E Krambeck
INTRODUCTION: Bladder diverticula can be congenital or secondary to benign prostatic hyperplasia with bladder outlet obstruction, and be a source of high postvoid residuals prompting surgical intervention. We sought to evaluate the outcomes of patients with bladder diverticula undergoing holmium laser enucleation of the prostate (HoLEP) for bladder outlet obstruction. METHODS: We retrospectively reviewed HoLEP patients with at least one bladder diverticulum at two high volume institutions...
October 31, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29076300/improvement-of-persistent-detrusor-overactivity-through-treatment-with-a-phytotherapeutic-agent-wsy-1075-after-relief-of-bladder-outlet-obstruction
#10
Su Jin Kim, Seung Hwan Jeon, Eun Bi Kwon, Hyun Cheol Jeong, Sae Woong Choi, Woong Jin Bae, Hyuk Jin Cho, U Syn Ha, Sung Hoo Hong, Ji Youl Lee, Sung Yeoun Hwang, Sae Woong Kim
PURPOSE: Many patients with benign prostatic hyperplasia need treatment for remaining storage symptoms after surgery. Therefore, we evaluated the effect of the phytotherapeutic agent WSY-1075 on persistent detrusor overactivity (DO) after the relief of bladder outlet obstruction (BOO). MATERIALS AND METHODS: Rats were assigned to 3 groups: control (n=6), persistent DO (n=6), and persistent DO treated with the phytotherapeutic agent WSY-1075 (n=6). Persistent DO after relief of partial BOO was generated in the rat model, and 6 of the rats with this condition were orally administered WSY-1075...
October 25, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/29071145/a-novel-algorithm-for-the-non-invasive-detection-of-bladder-outlet-obstruction-in-men-with-lower-urinary-tract-symptoms
#11
Fawzy Farag, Mohamed Elbadry, Mohammed Saber, Abdelbasset A Badawy, John Heesakkers
OBJECTIVE: To determine the ability of bladder wall thickness (BWT) in combination with non-invasive variables to distinguish patients with bladder outlet obstruction (BOO). PATIENTS AND METHODS: Patients completed the International Prostate Symptom Score (IPSS) questionnaire and prostate size was measured by transrectal ultrasonography (US). Pressure-flow studies were performed to determine the urodynamic diagnosis. BWT was measured at 250-mL bladder filling using transabdominal US...
June 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29064654/an-unusual-presentation-of-urethral-duplication-presenting-with-chronic-bladder-retention-left-scrotal-transposition-and-left-renal-agenesis
#12
Antonio Macedo, Marcela Leal da Cruz, João Luiz Gomes Parizi, Gustavo Marconi Caetano Martins, Riberto Liguori, Sérgio Leite Ottoni, Bruno Leslie, Gilmar Garrone
INTRODUCTION AND OBJECTIVE: Urethral duplication is a rare congenital anomaly, with roughly 200 cases reported in the literature (1). It is more frequent in males, with few cases reported in females. The clinical presentation differs according to the anatomical variant present. The duplication most commonly occurs in the sagittal plane with one urethra located ventrally and the other dorsally (2). Usually the ventral urethra is the more functional of both. Duplications occurring in the coronal plane are quite rare and they are usually associated with bladder duplication (3)...
October 24, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29058820/anterior-colporrhaphy-plus-inside-out-tension-free-vaginal-tape-for-associated-stress-urinary-incontinence-and-cystocele-10-year-follow-up-results
#13
Roberto Montera, Andrea Miranda, Francesco Plotti, Corrado Terranova, Daniela Luvero, Stella Capriglione, Giuseppe Scaletta, Marzio A Zullo, Maurizio Buscarini, Salvatore Lopez, Alessandra Gatti, Teresa Schirò, Carlo De Cicco Nardone, Roberto Angioli
AIMS: We report the success rate and complications rate of combined ultralateral anterior Colporrhaphy plus Tension-free Vaginal Tape (TVT-O) in a long-term (10 year) follow-up prospective survey. METHODS: Patients previously treated for associated stress urinary incontinence (SUI) and cystocele were subjected to annual follow-up for 10 year with a complete urogynecologic evaluation. Furthermore, an urodynamic assessment and a quality of life questionnaire (ICIQ-UI SF) were recorded at the 5th and 10th year of follow up...
October 23, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29046995/aquablation-of-the-prostate-for-symptomatic-benign-prostatic-hyperplasia-early-results
#14
REVIEW
Omid Yassaie, Joshua A Silverman, Peter J Gilling
Aquablation is a novel technique for the surgical management of bladder outlet obstruction secondary to benign prostatic hyperplasia. Following first-in-man studies, a multicenter trial was conducted with results now out to 1 year. Aquablation resulted in a mean International Prostate Symptom Score improvement of 16 points (p < 0.01) and a mean maximum urinary flow rate increase from 8.7 to 18.3 ml/s (p < 0.01) at 12 months. Due to the precise prostate mapping, aquablation has also demonstrated favorable sexual and urinary outcomes with no new erectile dysfunction, retrograde ejaculation, or urinary incontinence as often experienced with other techniques...
October 18, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/29046983/holmium-laser-enucleation-of-the-prostate-patient-selection-and-outcomes
#15
REVIEW
Joseph M Kuebker, Nicole L Miller
PURPOSE OF REVIEW: Holmium laser enucleation of the prostate (HoLEP) is a proven technique to alleviate bladder outlet obstruction (BOO) from benign prostatic hyperplasia (BPH). Herein, we review factors relevant to selecting patients who will benefit from this procedure and expected outcomes. RECENT FINDINGS: New randomized trials have validated the excellent outcomes achieved by HoLEP in the management of BOO from BPH. Its success has been reproduced in a diverse array of patients including those on anticoagulation, with detrusor underactivity/acontractility, prostate cancer, and in the retreatment setting...
October 19, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/29017737/laparoscopic-adenomectomy-10-years-of-experience
#16
J Carpio Villanueva, A Rosales Bordes, J Ponce de León Roca, M Montlleó González, J Caparrós Sariol, H Villavicencio Mavrich
INTRODUCTION: Lower urinary tract symptoms secondary to increased prostate volume are associated with ageing and are becoming more prevalent due to increased life expectancy. We present our experience with transperitoneal laparoscopic adenomectomy for the management of bladder outlet obstruction caused by benign prostatic enlargement. MATERIALS AND METHODS: We performed a retrospective review of patients who underwent laparoscopic adenomectomy between 2005 and 2015...
October 7, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28990728/female-bladder-outlet-obstruction-common-symptoms-masking-an-uncommon-cause
#17
Sachin Malde, Eskinder Solomon, Marco Spilotros, Bashir Mukhtar, Mahreen Pakzad, Rizwan Hamid, Jeremy Ockrim, Tamsin Greenwell
OBJECTIVE: Bladder outlet obstruction (BOO) in women remains an underdiagnosed condition. Although diagnosed rarely in general urologic practice, its incidence in specialist centers has been reported to be up to 29%. In the present study we evaluated the incidence of female BOO in adult women referred for evaluation of lower urinary tract symptoms or urinary incontinence, assessing its etiology and correlating this with its clinical presentation. METHODS: The present study consisted of a retrospective review of a prospectively acquired videourodynamic database of 1142 consecutive women referred for evaluation of lower urinary tract symptoms (LUTS) or urinary incontinence from March 2007 to December 2012 and diagnosed with BOO...
October 9, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28990332/the-expression-and-functional-activities-of-smooth-muscle-myosin-and-non-muscle-myosin-isoforms-in-rat-prostate
#18
Ping Chen, Jing Yin, Yu-Ming Guo, He Xiao, Xing-Huan Wang, Michael E DiSanto, Xin-Hua Zhang
Benign prostatic hyperplasia (BPH) is mainly caused by increased prostatic smooth muscle (SM) tone and volume. SM myosin (SMM) and non-muscle myosin (NMM) play important roles in mediating SM tone and cell proliferation, but these molecules have been less studied in the prostate. Rat prostate and cultured primary human prostate SM and epithelial cells were utilized. In vitro organ bath studies were performed to explore contractility of rat prostate. SMM isoforms, including SM myosin heavy chain (MHC) isoforms (SM1/2 and SM-A/B) and myosin light chain 17 isoforms (LC17a/b ), and isoform ratios were determined via competitive RT-PCR...
October 9, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28984997/nlrp3-il-1%C3%AE-mediates-denervation-during-bladder-outlet-obstruction-in-rats
#19
Robin Lütolf, Francis M Hughes, Brian M Inouye, Huixia Jin, Jennifer C McMains, Elena S Pak, Johanna L Hannan, J Todd Purves
AIMS: Denervation of the bladder is a detrimental consequence of bladder outlet obstruction (BOO). We have previously shown that, during BOO, inflammation triggered by the NLRP3 inflammasome in the urothelia mediates physiological bladder dysfunction and downstream fibrosis in rats. The aim of this study was to assess the effect of NLRP3-mediated inflammation on bladder denervation during BOO. METHODS: There were five groups of rats: (i) Control (no surgery); (ii) Sham-operated; (iii) BOO rats given vehicle; (iv) BOO rats given the NLRP3 inhibitor glyburide; and (v) BOO rats given the IL-1 receptor antagonist anakinra...
October 6, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28965358/benefits-and-limitations-of-animal-models-in-partial-bladder-outlet-obstruction-for-translational-research
#20
REVIEW
Takeya Kitta, Yukiko Kanno, Hiroki Chiba, Madoka Higuchi, Mifuka Ouchi, Mio Togo, Kimihiko Moriya, Nobuo Shinohara
The functions of the lower urinary tract have been investigated for more than a century. Lower urinary tract symptoms, such as incomplete bladder emptying, weak urine stream, daytime urinary frequency, urgency, urge incontinence and nocturia after partial bladder outlet obstruction, is a frequent cause of benign prostatic hyperplasia in aging men. However, the pathophysiological mechanisms have not been fully elucidated. The use of animal models is absolutely imperative for understanding the pathophysiological processes involved in bladder dysfunction...
October 1, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
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