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https://www.readbyqxmd.com/read/28538709/minimal-invasive-cystometry-and-intra-abdominal-pressure-assessments-in-rodents-a-novel-animal-study
#1
Yafei Yang, Jin Yang, Lin Chen, Jianyun Hu, Shasha Xing, Bastian Amend, Arnulf Stenzl, Xin Wei, Haifeng Hu
BACKGROUND The abdominal straining pattern can act as a novel parameter for improving the prediction of bladder outlet obstruction (BOO). To preserve detrusor function in the early stage of urinary system impairment, such as BOO, we establish a novel method for cystometry and Intra-abdominal pressure (IAP) assessments in rodents without cystostomy. MATERIAL AND METHODS Twenty mice and rats were divided into three groups (control, sham-operated and BOO group) respectively. The cystometry and IAP assessments were measured by the pediatric venous indwelling sheath and coronary dilatation catheter connected to Laborie urodynamic system on postoperative day 7...
May 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28536217/caution-advised-with-dapagliflozin-in-the-setting-of-male-urinary-tract-outlet-obstruction
#2
Victoria Hall, Jason Kwong, Douglas Johnson, Elif Ilhan Ekinci
We describe an adverse outcome in a 70-year-old man with type 2 diabetes mellitus treated with sodium-glucose cotransporter type 2 (SGLT2) inhibitor dapagliflozin. SGLT2 inhibitors act in the proximal tubules to prevent glucose reabsorption and induce urinary glucose excretion, they have been associated with increased risk of urinary tract infection (UTI). Our patient presented to hospital with Escherichia coli septicaemia with positive urine and blood cultures on the background of two previous UTIs occurring post commencement of dapagliflozin in the community...
May 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28518071/nerve-sparing-mid-urethral-obstruction-nemo-in-female-small-rodents
#3
Martin Sidler, Karen J Aitken, Jia Xin Jiang, Darius J Bägli
Partial bladder outlet obstruction (pBOO) has a high prevalence, causes significant patient burden, and immense health care costs. The most common animal model to investigate bladder remodeling in pBOO are female rodents undergoing partial obstruction at the proximal urethra. Variability in the degree of obstruction and animal mortality are major concerns with proximal obstruction. Furthermore, dissecting around the proximal urethra and bladder neck jeopardizes bladder innervation. We developed a nerve-sparing mid-urethral obstruction (NeMO) model for pBOO avoiding the disadvantages of the traditional model...
April 25, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28506859/the-obstructed-bladder-expression-of-collagen-matrix-metalloproteinases-muscarinic-receptors-angiogenic-and-neurotrophic-factors-in-patients-with-benign-prostatic-hyperplasia
#4
João Arthur Brunhara Alves Barbosa, Sabrina T Reis, Marco Nunes, Yuri A Ferreira, Katia R Leite, William C Nahas, Miguel Srougi, Alberto A Antunes
OBJECTIVE: to evaluate gene expression of Collagen, Matrix Metalloproteinases (MMP) and Inhibitors, Cholinergic Muscarinic Receptors (CHRM), Angiogenic and Nerve Growth Factors (NGF) in the bladder of patients with Bladder Outlet Obstruction due to Benign Prostatic Hyperplasia METHODS: We analyzed bladder specimens from 43 patients with obstructive BPH undergoing TURP as compared to 10 age-matched controls with IPSS<8 and prostate <30g. A bladder biopsy was performed for relative gene expression analysis with qRT-PCR of Collagens I and III, MMPs 1,2,9; Tissue Inhibitors of Metalloproteinases (TIMP) 1,2 and RECK; CHRM2 and -3; VEGF, CD105; NGF and NGF receptor...
May 12, 2017: Urology
https://www.readbyqxmd.com/read/28499730/effects-of-withdrawing-alpha-1-blocker-from-the-combination-therapy-with-alpha-1-blocker-and-5-alpha-reductase-inhibitor-in-patients-with-lower-urinary-tract-symptoms-suggestive-of-benign-prostatic-hyperplasia-a-prospective-and-comparative-trial-using-urodynamics
#5
Yoshihisa Matsukawa, Shun Takai, Yasuhito Funahashi, Tsuyoshi Majima, Masashi Kato, Tokunori Yamamoto, Momokazu Gotoh
PURPOSE: To compare the effects on lower urinary tract symptoms (LUTS) and bladder outlet obstruction between combination therapy with α1 blocker and 5α-reductase inhibitor and a switch to 5α-reductase inhibitor monotherapy, and determine the factors influencing changes in LUTS after α1 blocker withdrawal. MATERIALS AND METHODS: One-hundred and forty outpatients with LUTS suggestive of benign prostatic hyperplasia received combination therapy with silodosin 8 mg/day and dutasteride 0...
May 9, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28476482/report-on-the-society-for-fetal-urology-panel-discussion-on-the-selection-criteria-and-intervention-for-fetal-bladder-outlet-obstruction
#6
M K Farrugia, M C Braun, C A Peters, R Ruano, C D Herndon
INTRODUCTION: The Society for Fetal Urology panel section at the 2016 Fall Congress featured a multidisciplinary discussion on appropriate patient selection, the conservative versus surgical management, and postnatal renal outcome of fetuses with lower urinary tract obstruction (LUTO). SELECTION CRITERIA FOR INTERVENTION: Rodrigo Ruano shared his experience of prenatal intervention, presenting the outcome of 111 fetuses with severe LUTO treated with vesicoamniotic shunting (VAS) (n = 16), cystoscopy (n = 34) or no intervention (n = 61) in a non-randomized series...
March 24, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28462670/transurethral-enucleation-with-bipolar-for-benign-prostatic-hyperplasia-2-year-outcomes-and-the-learning-curve-of-a-single-surgeon-s-experience-of-603-consecutive-patients
#7
Yosuke Hirasawa, Yuji Kato, Kiichiro Fujita
BACKGROUND: To investigate perioperative outcomes, the learning curve, and 2-year follow-up after transurethral enucleation with bipolar (TUEB) for patients with benign prostatic hyperplasia (BPH). METHODS: From December 2011 to October 2016, 603 consecutive patients underwent TUEB for BPH, performed by a single surgeon. Patients were preoperatively assessed by using the International Prostate Symptom Score (IPSS), quality-of-life score (QOLs), serum prostate-specific antigen (PSA), and uroflowmetry evaluation...
May 25, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28446011/development-of-decision-support-formulas-for-the-prediction-of-bladder-outlet-obstruction-and-prostatic-surgery-in-patients-with-lower-urinary-tract-symptom-benign-prostatic-hyperplasia-part-ii-external-validation-and-usability-testing-of-a-smartphone-app
#8
Min Soo Choo, Seong Jin Jeong, Sung Yong Cho, Changwon Yoo, Chang Wook Jeong, Ja Hyeon Ku, Seung-June Oh
PURPOSE: We aimed to externally validate the prediction model we developed for having bladder outlet obstruction (BOO) and requiring prostatic surgery using 2 independent data sets from tertiary referral centers, and also aimed to validate a mobile app for using this model through usability testing. METHODS: Formulas and nomograms predicting whether a subject has BOO and needs prostatic surgery were validated with an external validation cohort from Seoul National University Bundang Hospital and Seoul Metropolitan Government-Seoul National University Boramae Medical Center between January 2004 and April 2015...
April 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28446010/development-of-decision-support-formulas-for-the-prediction-of-bladder-outlet-obstruction-and-prostatic-surgery-in-patients-with-lower-urinary-tract-symptom-benign-prostatic-hyperplasia-part-i-development-of-the-formula-and-its-internal-validation
#9
Min Soo Choo, Changwon Yoo, Sung Yong Cho, Seong Jin Jeong, Chang Wook Jeong, Ja Hyeon Ku, Seung-June Oh
PURPOSE: As the elderly population increases, a growing number of patients have lower urinary tract symptom (LUTS)/benign prostatic hyperplasia (BPH). The aim of this study was to develop decision support formulas and nomograms for the prediction of bladder outlet obstruction (BOO) and for BOO-related surgical decision-making, and to validate them in patients with LUTS/BPH. METHODS: Patient with LUTS/BPH between October 2004 and May 2014 were enrolled as a development cohort...
April 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28444709/male-bladder-outlet-obstruction-time-to-re-evaluate-the-definition-and-reconsider-our-diagnostic-pathway-ici-rs-2015
#10
REVIEW
Kevin Rademakers, Marcus J Drake, Andrew Gammie, Jens C Djurhuus, Peter F W M Rosier, Paul Abrams, Christopher Harding
The diagnosis of bladder outlet obstruction (BOO) in the male is dependent on measurements of pressure and flow made during urodynamic studies. The procedure of urodynamics and the indices used to delineate BOO are well standardized largely as a result of the work of the International Continence Society. The clinical utility of the diagnosis of BOO is however, less well defined and there are several shortcomings and gaps in the currently available medical literature. Consequently the International Consultation on Incontinence Research Society (ICI-RS) held a think tank session in 2015 entitled "Male bladder outlet obstruction: Time to re-evaluate the definition and reconsider our diagnostic pathway?" This manuscript details the discussions that took place within that think tank setting out the pros and cons of the current definition of BOO and exploring alternative clinical tests (alone or in combination) which may be useful in the future investigation of male patients with lower urinary tract symptoms...
April 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28436120/efficacy-of-holmium-laser-transurethral-incision-of-the-prostate-in-symptomatic-mild-to-moderate-benign-prostate-enlargement-based-on-preoperative-characteristics
#11
Yoon Seok Suh, Kwang Jin Ko, Tae Heon Kim, Hyun Hwan Sung, Kyu-Sung Lee
OBJECTIVE: To investigate the efficacy of Holmium laser transurethral incision of the prostate (Ho-TUIP) with preoperative characteristics based on urodynamic parameters. METHODS: The medical records of 40 consecutive cases of Ho-TUIP in patients unresponsive to medical treatment were retrospectively reviewed. The efficacy of Ho-TUIP was analyzed according to preoperative factors, including urodynamic parameters. Treatment success was confirmed if overall efficacy demonstrated an improvement that was "good or greater" according to the criteria developed by Homma et al...
April 23, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28417428/outcomes-of-minimally-invasive-inguinal-hernia-repair-at-the-time-of-robotic-radical-prostatectomy
#12
REVIEW
Francois G Soto-Palou, Ricardo F Sánchez-Ortiz
Abdominal straining associated with voiding dysfunction or constipation has traditionally been associated with the development of abdominal wall hernias. Thus, classic general surgery dictum recommends that any coexistent bladder outlet obstruction should be addressed by the urologist before patients undergo surgical repair of a hernia. While organ-confined prostate cancer is usually not associated with the development of lower urinary tract symptoms, a modest proportion of patients treated with radical prostatectomy may have coexisting benign prostatic hyperplasia with elevated symptom scores and hernias may be incidentally detected at the time of surgery...
June 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28417339/expression-and-function-of-the-small-conductance-ca-2-activated-k-channel-is-decreased-in-urinary-bladder-smooth-muscle-cells-from-female-guinea-pig-with-partial-bladder-outlet-obstruction
#13
Ning Li, Honglin Ding, Xiaoning He, Zizheng Li, Yili Liu
PURPOSE: Overactive bladder (OAB), usually accompanied by partial bladder outlet obstruction (PBOO), is associated with detrusor overactivity (DO) which is related to the increased urinary bladder smooth muscle (UBSM) cells excitability. Small-conductance Ca(2+)-activated K(+) (SK) channels play a constitutive regulatory role of UBSM excitability and contractility. PBOO is associated with the decreased SK channels mRNA expression and the attenuated regulative effect of SK channels on UBSM contractility...
April 17, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28403592/comparison-of-transurethral-incision-of-the-prostate-and-silodosin-in-patients-having-benign-prostatic-obstruction-in-terms-of-retrograde-ejaculation
#14
Basri Cakiroglu, Aydin Ismet Hazar, Orhun Sinanoglu, Ersan Arda, Sinan Ekici
BACKGROUND: To compare the functional outcomes and retrograde ejaculation (RE) after transurethral incision of the prostate (TUIP) or silodosin in bladder outlet obstruction (BOO) secondary to a small prostate. METHODS: Prospectively collected data from December 2011 through December 2014 of 192 LUTS patients having fertility concerns with prostate volume smaller than 40 ml receiving either TUIP or silodosin treatment were prospectively reviewed. The treatment outcomes were evaluated and compared...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28394496/change-of-ultrasound-estimated-bladder-weight-and-bladder-wall-thickness-after-treatment-of-bladder-outlet-obstruction-with-dutasteride
#15
Ha Na Lee, Young-Suk Lee, Deok Hyun Han, Kyu-Sung Lee
OBJECTIVES: To investigate the change of bladder wall hypertrophy to relieve bladder outlet obstruction (BOO) by treatment with 5α-reductase inhibitor. METHODS: Men who have BOO confirmed by urodynamic study (BOO index ≥40) were treated with dutasteride 0.5 mg once a day for 6 months. We measured ultrasound estimated bladder weight (UEBW), UEBW divided by body surface area (UEBW/BSA), and bladder wall thickness (BWT) before and after treatment. Changes in LUTS parameters were assessed by using the International Prostate Symptom Score, uroflowmetry, residual urine volume, prostate volume, serum prostate-specific antigen (PSA), and LUTS outcome scores (LOS)...
May 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28394495/effect-of-naftopidil-on-bladder-microcirculation-in-a-rat-model-of-bladder-outlet-obstruction
#16
Tsuyoshi Majima, Tokunori Yamamoto, Yasuhito Funahashi, Shun Takai, Yoshihisa Matsukawa, Masaki Yoshida, Momokazu Gotoh
OBJECTIVES: To evaluate the effect of naftopidil on bladder capillary blood flow using bladder outlet obstruction model rats. METHODS: Female Sprague-Dawley rats were divided into three groups: control group, bladder-outlet-obstruction group, and bladder-outlet-obstruction + naftopidil group. Bladder-outlet-obstruction surgery was performed in the bladder-outlet-obstruction and bladder-outlet-obstruction + naftopidil groups. The control group received sham-operation...
May 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28394493/synergic-suppressive-effect-of-silodosin-and-imidafenacin-on-non-voiding-bladder-contractions-in-male-rats-with-subacute-bladder-outlet-obstruction
#17
Rino Sugiyama, Naoki Aizawa, Hiroki Ito, Tetsuya Fujimura, Motofumi Suzuki, Tohru Nakagawa, Hiroshi Fukuhara, Haruki Kume, Yukio Homma, Yasuhiko Igawa
OBJECTIVES: To investigate single or combined effect of silodosin, an α1A-adrenoceptor antagonist, and imidafenacin, an antimuscarinic agent, on bladder function in a subacute bladder outlet obstruction (BOO) model of male rats. METHODS: Partial BOO was created in male Wistar rats by ligating the urethra with a steel rod. On day 10 after surgery, when frequent voiding was most remarkable on voiding behavior measurement in a metabolic cage, cystometric investigations in a conscious restrained condition were conducted with cumulative intravenous administration of silodosin alone (0...
May 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28389177/commentary-to-report-on-the-society-for-fetal-urology-panel-discussion-on-the-selection-criteria-and-intervention-for-fetal-bladder-outlet-obstruction
#18
Michael C Carr
No abstract text is available yet for this article.
March 23, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28376105/video-urodynamic-characteristics-of-non-neurogenic-idiopathic-underactive-bladder-in-men-a-comparison-of-men-with-normal-tracing-and-bladder-outlet-obstruction
#19
Yuan-Hong Jiang, Hann-Chorng Kuo
OBJECTIVE: Underactive bladder is frequently encountered in elderly patients. It may result from detrusor underactivity (DU) or low detrusor contractility due to a urethral sphincter inhibitory effect. This study analyzed the video-urodynamic study (VUDS) characteristics of patients with underactive bladder in a large cohort of men with lower urinary tract symptoms (LUTS). METHODS: Male patients with LUTS who had failed the initial treatment were consecutively enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28370456/predictors-for-detrusor-overactivity-following-extensive-vaginal-pelvic-reconstructive-surgery
#20
Tsia-Shu Lo, Shailaja Nagashu, Wu-Chiao Hsieh, Ma Clarissa Uy-Patrimonio, Lin Yi-Hao
AIM: This study aims to identify the predictors for detrusor overactivity (DO) in women following extensive vaginal pelvic reconstructive surgery (PRS) for advanced pelvic organ prolapse (POP). METHODS: We enrolled 1503 women who had prolapse POP-Q stage ≥ 3 and underwent vaginal PRS with or without MUS from January 2006 to December 2015. All subjects completed a 72-h voiding diary, IIQ-7, UDI-6, POPDI-6, and PISQ-12. Urodynamics (UDS) was performed pre- and post-operatively...
March 31, 2017: Neurourology and Urodynamics
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