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https://www.readbyqxmd.com/read/29769289/metarrestin-a-perinucleolar-compartment-inhibitor-effectively-suppresses-metastasis
#1
Kevin J Frankowski, Chen Wang, Samarjit Patnaik, Frank J Schoenen, Noel Southall, Dandan Li, Yaroslav Teper, Wei Sun, Irawati Kandela, Deqing Hu, Christopher Dextras, Zachary Knotts, Yansong Bian, John Norton, Steve Titus, Marzena A Lewandowska, Yiping Wen, Katherine I Farley, Lesley Mathews Griner, Jamey Sultan, Zhaojing Meng, Ming Zhou, Tomas Vilimas, Astin S Powers, Serguei Kozlov, Kunio Nagashima, Humair S Quadri, Min Fang, Charles Long, Ojus Khanolkar, Warren Chen, Jinsol Kang, Helen Huang, Eric Chow, Esthermanya Goldberg, Coral Feldman, Romi Xi, Hye Rim Kim, Gary Sahagian, Susan J Baserga, Andrew Mazar, Marc Ferrer, Wei Zheng, Ali Shilatifard, Jeffrey Aubé, Udo Rudloff, Juan Jose Marugan, Sui Huang
Metastasis remains a leading cause of cancer mortality due to the lack of specific inhibitors against this complex process. To identify compounds selectively targeting the metastatic state, we used the perinuclear compartment (PNC), a complex nuclear structure associated with metastatic behaviors of cancer cells, as a phenotypic marker for a high-content screen of over 140,000 structurally diverse compounds. Metarrestin, obtained through optimization of a screening hit, disassembles PNCs in multiple cancer cell lines, inhibits invasion in vitro, suppresses metastatic development in three mouse models of human cancer, and extends survival of mice in a metastatic pancreatic cancer xenograft model with no organ toxicity or discernable adverse effects...
May 16, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29610727/modified-back-contact-interface-of-cztse-thin-film-solar-cells-elimination-of-double-layer-distribution-in-absorber-layer
#2
Zhaojing Zhang, Liyong Yao, Yi Zhang, Jianping Ao, Jinlian Bi, Shoushuai Gao, Qing Gao, Ming-Jer Jeng, Guozhong Sun, Zhiqiang Zhou, Qing He, Yun Sun
Double layer distribution exists in Cu2 SnZnSe4 (CZTSe) thin films prepared by selenizing the metallic precursors, which will degrade the back contact of Mo substrate to absorber layer and thus suppressing the performance of solar cell. In this work, the double-layer distribution of CZTSe film is eliminated entirely and the formation of MoSe2 interfacial layer is inhibited successfully. CZTSe film is prepared by selenizing the precursor deposited by electrodeposition method under Se and SnSe x mixed atmosphere...
February 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29592780/downregulation-of-neuroligin1-ameliorates-postoperative-pain-through-inhibiting-neuroligin1-postsynaptic-density-95-mediated-synaptic-targeting-of-%C3%AE-amino-3-hydroxy-5-methyl-4-isoxazole-propionate-receptor-glua1-subunits-in-rat-dorsal-horns
#3
Ruijuan Guo, Huili Li, Xueyang Li, Zhaojing Xue, Yuqing Sun, Danxu Ma, Yun Guan, Junfa Li, Ming Tian, Yun Wang
Neuroligin1 is an important synaptic cell adhesion molecule that modulates the function of synapses through protein-protein interactions. Yet, it remains unclear whether the regulation of synaptic transmission in the spinal cord by neruoligin1 contributes to the development of postoperative pain. In a rat model of postoperative pain induced by plantar incision, we conducted Western blot study to examine changes in the expression of postsynaptic membrane of neuroligin1, postsynaptic density 95 (PSD-95), and α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor GluA1 and GluA2 subunits in the spinal cord dorsal horn after injury...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29510338/mcra-sequencing-reveals-the-role-of-basophilic-methanogens-in-a-cathodic-methanogenic-community
#4
Weiwei Cai, Wenzong Liu, Zhaojing Zhang, Kai Feng, Ge Ren, Chuanliang Pu, Haishu Sun, Jiaqi Li, Ye Deng, Aijie Wang
Cathodic methanogenesis is a promising method for accelerating and stabilising bioenergy recovery in anaerobic processes. The change in composition of microbial (especially methanogenic) communities in response to an applied potential-and especially the associated pH gradient-is critical for achieving this goal, but is not well understood in cathodic biofilms. We found here that the pH-polarised region in the 2 mm surrounding the cathode ranged from 6.9 to 10.1, as determined using a pH microsensor; this substantially affected methane production rate as well as microbial community structure...
June 1, 2018: Water Research
https://www.readbyqxmd.com/read/29432833/structure-of-an-entangled-heteropolysaccharide-from-pholidota-chinensis-lindl-and-its-antioxidant-and-anti-cancer-properties
#5
Dianhui Luo, Zhaojing Wang, Zhiming Li, Xiao-Qiang Yu
A major polysaccharide PCP-I was isolated and purified from Pholidota chinensis Lindl. The physicochemical and structural properties of PCP-I were studied using high-performance size-exclusion chromatography (HPSEC), gas chromatography (GC), Fourier transform infrared spectroscopy (FTIR), periodate oxidation-smith degradation, methylation-GC-MS analysis, nuclear magnetic resonance (NMR) spectroscopy and transmission electron microscopy (TEM) analysis. PCP-I was homogeneous with molecular weight (Mw) of 249kDa and composed of xylose and fucose at a molar ratio of 2...
June 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29422863/-n-n-butyl-haloperidol-iodide-a-derivative-of-the-anti-psychotic-haloperidol-antagonizes-hypoxia-reoxygenation-injury-by-inhibiting-an-egr-1-ros-positive-feedback-loop-in-h9c2-cells
#6
Ting Sun, Yanmei Zhang, Shuping Zhong, Fenfei Gao, Yicun Chen, Bin Wang, Wenfeng Cai, Zhaojing Zhang, Weiqiu Li, Shishi Lu, Fuchun Zheng, Ganggang Shi
Early growth response-1 (Egr-1), a transcription factor which often underlies the molecular basis of myocardial ischemia/reperfusion (I/R) injury, and oxidative stress, is key to myocardial I/R injury. Silent information regulator of transcription 1(SIRT1) not only interacts with and is inhibited by Egr-1, but also downregulates reactive oxygen species (ROS) via the Forkhead box O1(FOXO1)/manganese superoxide dismutase (Mn-SOD) signaling pathway. N -n-butyl haloperidol iodide (F2 ), a new patented compound, protects the myocardium against myocardial I/R injury in various animal I/R models in vivo and various heart-derived cell hypoxia/reoxygenation (H/R) models in vitro ...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29378712/a-10-year-comparative-analysis-shows-that-increasing-prevalence-of-rifampin-resistant-mycobacterium-tuberculosis-in-china-is-associated-with-the-transmission-of-strains-harboring-compensatory-mutations
#7
Fengmin Huo, Jingjing Luo, Jin Shi, Zhaojing Zong, Wei Jing, Wenzhu Dong, Lingling Dong, Yifeng Ma, Qian Liang, Yuanyuan Shang, Hairong Huang, Yu Pang
In this work, we conducted bacterial population profile studies to assess trends of rifampin (RIF) resistance of Mycobacterium tuberculosis isolates collected across China from 2005 to 2015. Totals of 273 and 269 randomly selected M. tuberculosis isolates from 2005 and 2015, respectively, were analyzed. The rates of RIF resistance (36.4%), isoniazid resistance (39.0%), and levofloxacin resistance (25.7%) in 2015 were significantly higher than those in 2005 (28.2%, 30.0%, and 15.4%, respectively; P < 0.05)...
April 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29303168/copper-guanidine-catalyzed-asymmetric-alkynylation-of-isatin-derived-ketimines
#8
Quangang Chen, Lihua Xie, Zhaojing Li, Yu Tang, Peng Zhao, Lili Lin, Xiaoming Feng, Xiaohua Liu
Isatin-derived ketimines undergo enantioselective alkynylation reactions in the presence of copper iodide and easily accessible guanidine-amides. The corresponding 3-alkynyl-3-aminooxyindoles are obtained in up to 95% yield and 96% ee. The guanidine plays a role in the formation of copper acetylide and the enantiodetermining step and the basic additive is excluded.
January 16, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29188359/biosynthesis-of-gold-nanoparticles-using-cell-free-extracts-of-magnusiomyces-ingens-lh-f1-for-nitrophenols-reduction
#9
Yuanyuan Qu, Shengnan You, Xuwang Zhang, Xiaofang Pei, Wenli Shen, Zhichao Li, Shuzhen Li, Zhaojing Zhang
A green and eco-friendly method for the synthesis of gold nanoparticles (AuNPs) was developed using the cell-free extracts of a yeast strain Magnusiomyces ingens LH-F1. UV-vis spectra showed a distinct absorption band at ~ 540 nm, corresponding to the surface plasmon resonance of AuNPs. Transmission electron microscopy images revealed that the shapes of AuNPs were almost spherical and pseudo-spherical. Fourier transform infrared spectroscopy and sodium dodecyl sulfate-polyacrylamide gel electrophoresis analyses suggested that some proteins containing amino- and carboxyl-groups in the cell-free extracts were absorbed on the surface of nanoparticles, which could act as reducing and capping agents for AuNPs synthesis...
March 2018: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29103021/hsa_circ_0000520-a-potential-new-circular-rna-biomarker-is-involved-in-gastric-carcinoma
#10
Handong Sun, Weiwei Tang, Dawei Rong, Hui Jin, Kai Fu, Wenling Zhang, Zhaojing Liu, Hongyong Cao, Xiufeng Cao
BACKGROUND: Circular RNAs (circRNAs) have been found playing important roles in regulating cancer progression. Human circRNA microarray was performed to screen for abnormally expressed circRNA in gastric cancer tissues. In this study, we are aimed to investigate the relationship between a new circular RNA named hsa_circ_0000520 and gastric cancer development. METHODS: The hsa_circ_0000520 levels were detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in gastric tissue, cell and plasma levels, respectively...
February 6, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28981088/hsf4-regulates-lens-fiber-cell-differentiation-by-activating-p53-and-its-downstream-regulators
#11
Meng Gao, Yuwen Huang, Ling Wang, Mi Huang, Fei Liu, Shengjie Liao, Shanshan Yu, Zhaojing Lu, Shanshan Han, Xuebin Hu, Zhen Qu, Xiliang Liu, Tinsae Assefa Yimer, Lifang Yang, Zhaohui Tang, David Wan-Cheng Li, Mugen Liu
Cataract refers to opacities of the lens that impede the passage of light. Mutations in heat shock transcription factor 4 (HSF4) have been associated with cataract; however, the mechanisms regarding how mutations in HSF4 cause cataract are still obscure. In this study, we generated an hsf4 knockout zebrafish model using TALEN technology. The mutant zebrafish developed an early-onset cataract with multiple developmental defects in lens. The epithelial cells of the lens were overproliferated, resulting in the overabundance of lens fiber cells in hsf4(null) zebrafish lens...
October 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28959248/rifabutin-resistance-associated-with-double-mutations-in-rpob-gene-in-mycobacterium-tuberculosis-isolates
#12
Wei Jing, Yu Pang, Zhaojing Zong, Jing Wang, Ru Guo, Fengmin Huo, Guanglu Jiang, Yifeng Ma, Hairong Huang, Naihui Chu
The objective of this study was to investigate the cross-resistance between rifampin (RIF) and rifabutin (RFB) among clinical Mycobacterium tuberculosis (MTB) isolates, and the correlations between specific rpoB mutations and the minimum inhibitory concentrations (MICs) of RIF and RFB. A total of 256 RIF-resistant isolates were included from the National Tuberculosis Clinical Laboratory in China. The MICs of MTB isolates against RIF and RFB were determined by using a microplate alamarBlue assay. In addition, all the MTB isolates were sequenced for mutations in rpoB gene...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28926148/biodiversity-and-species-competition-regulate-the-resilience-of-microbial-biofilm-community
#13
Kai Feng, Zhaojing Zhang, Weiwei Cai, Wenzong Liu, Meiying Xu, Huaqun Yin, Aijie Wang, Zhili He, Ye Deng
The relationship between biodiversity and ecosystem stability is poorly understood in microbial communities. Biofilm communities in small bioreactors called microbial electrolysis cells (MEC) contain moderate species numbers and easy tractable functional traits, thus providing an ideal platform for verifying ecological theories in microbial ecosystems. Here, we investigated the resilience of biofilm communities with a gradient of diversity, and explored the relationship between biodiversity and stability in response to a pH shock...
November 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28752308/green-synthesis-of-gold-nanoparticles-using-fungus-mariannaea-sp-hj-and-their-catalysis-in-reduction-of-4-nitrophenol
#14
Xiaofang Pei, Yuanyuan Qu, Wenli Shen, Huijie Li, Xuwang Zhang, Shuzhen Li, Zhaojing Zhang, Xuanying Li
In the present study, biosynthesis of gold nanoparticles (AuNPs) by the cells (cells-AuNPs) and cell-free extracts (extracts-AuNPs) of a new fungus Mariannaea sp. HJ was reported. The as-synthesized particles were characterized by UV-vis spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The effects of different parameters on AuNP biosynthesis were investigated, and initial gold ion concentration of 2 mM, pH 7, was demonstrated to be suitable for both cells-AuNP and extracts-AuNP syntheses...
September 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28739779/in-vitro-drug-susceptibility-of-bedaquiline-delamanid-linezolid-clofazimine-moxifloxacin-and-gatifloxacin-against-extensively-drug-resistant-tuberculosis-in-beijing-china
#15
Yu Pang, Zhaojing Zong, Fengmin Huo, Wei Jing, Yifeng Ma, Lingling Dong, Yunxu Li, Liping Zhao, Yuhong Fu, Hairong Huang
Extensively drug-resistant tuberculosis (XDR-TB) is a deadly form of TB that can be incurable due to its extreme drug resistance. In this study, we aimed to explore the in vitro susceptibility to bedaquiline (BDQ), delamanid (DMD), linezolid (LZD), clofazimine (CLO), moxifloxacin (MFX), and gatifloxacin (GAT) of 90 XDR-TB strains isolated from patients in China. We also describe the genetic characteristics of XDR-TB isolates with acquired drug resistance. Resistance to MFX, GAT, LZD, CLO, DMD, and BDQ was found in 82 (91...
October 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28684789/soil-bacterial-quantification-approaches-coupling-with-relative-abundances-reflecting-the-changes-of-taxa
#16
Zhaojing Zhang, Yuanyuan Qu, Shuzhen Li, Kai Feng, Shang Wang, Weiwei Cai, Yuting Liang, Hui Li, Meiying Xu, Huaqun Yin, Ye Deng
Understanding the abundance change of certain bacterial taxa is quite important for the study of soil microbiology. However, the observed differences of relative abundances by high-throughput techniques may not accurately reflect those of the actual taxon abundances. This study investigated whether soil microbial abundances coupling with microbial quantities can be more informative in describing the microbial population distribution under different locations. We analyzed relative abundances of the major species in soil microbial communities from Beijing and Tibet grasslands by using 16 S rRNA high-throughput sequencing technique, and quantified the absolute bacterial cell numbers directly or indirectly by multiple culture-independent measurements, including adenosine tri-phosphate (ATP), flow cytometry (FCM), quantitative real-time PCR (qPCR), phospholipid fatty acids (PLFA) and microbial biomass Carbon (MBC)...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28530386/controllable-growth-of-ga-film-electrodeposited-from-aqueous-solution-and-cu-in-ga-se2-solar-cells
#17
Jinlian Bi, Jianping Ao, Qing Gao, Zhaojing Zhang, Guozhong Sun, Qing He, Zhiqiang Zhou, Yun Sun, Yi Zhang
Electrodepositon of Ga film is very challenging due to the high standard reduction potential (-0.53 V vs SHE for Ga(3+)). In this study, Ga film with compact structure was successfully deposited on the Mo/Cu/In substrate by the pulse current electrodeposition (PCE) method using GaCl3 aqueous solution. A high deposition rate of Ga(3+) and H(+) can be achieved by applying a large overpotential induced by high pulse current. In the meanwhile, the concentration polarization induced by cation depletion can be minimized by changing the pulse frequency and duty cycle...
June 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28398482/cerkl-gene-knockout-disturbs-photoreceptor-outer-segment-phagocytosis-and-causes-rod-cone-dystrophy-in-zebrafish
#18
Shanshan Yu, Chang Li, Lincoln Biswas, Xuebin Hu, Fei Liu, James Reilly, Xiliang Liu, Ying Liu, Yuwen Huang, Zhaojing Lu, Shanshan Han, Lei Wang, Jing Yu Liu, Tao Jiang, Xinhua Shu, Fulton Wong, Zhaohui Tang, Mugen Liu
In humans, CERKL mutations cause widespread retinal degeneration: early dysfunction and loss of rod and cone photoreceptors in the outer retina and, progressively, death of cells in the inner retina. Despite intensive efforts, the function of CERKL remains obscure and studies in animal models have failed to clarify the disease mechanism of CERKL mutations. To address this gap in knowledge, we have generated a stable CERKL knockout zebrafish model by TALEN technology and a 7bp deletion in CERKL cDNA that caused the premature termination of CERKL...
June 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28378834/ablation-of-eys-in-zebrafish-causes-mislocalisation-of-outer-segment-proteins-f-actin-disruption-and-cone-rod-dystrophy
#19
Zhaojing Lu, Xuebin Hu, Fei Liu, Dinesh C Soares, Xiliang Liu, Shanshan Yu, Meng Gao, Shanshan Han, Yayun Qin, Chang Li, Tao Jiang, Daji Luo, An-Yuan Guo, Zhaohui Tang, Mugen Liu
Mutations in EYS are associated with autosomal recessive retinitis pigmentosa (arRP) and autosomal recessive cone-rod dystrophy (arCRD) however, the function of EYS and the molecular mechanisms of how these mutations cause retinal degeneration are still unclear. Because EYS is absent in mouse and rat, and the structure of the retina differs substantially between humans and Drosophila, we utilised zebrafish as a model organism to study the function of EYS in the retina. We constructed an EYS-knockout zebrafish-line by TALEN technology which showed visual impairment at an early age, while the histological and immunofluorescence assays indicated the presence of progressive retinal degeneration with a cone predominately affected pattern...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28209709/pathogenic-mutations-in-retinitis-pigmentosa-2-predominantly-result-in-loss-of-rp2-protein-stability-in-humans-and-zebrafish
#20
Fei Liu, Yayun Qin, Shanshan Yu, Dinesh C Soares, Lifang Yang, Jun Weng, Chang Li, Meng Gao, Zhaojing Lu, Xuebin Hu, Xiliang Liu, Tao Jiang, Jing Yu Liu, Xinhua Shu, Zhaohui Tang, Mugen Liu
Mutations in retinitis pigmentosa 2 ( RP2 ) account for 10-20% of X-linked retinitis pigmentosa (RP) cases. The encoded RP2 protein is implicated in ciliary trafficking of myristoylated and prenylated proteins in photoreceptor cells. To date >70 mutations in RP2 have been identified. How these mutations disrupt the function of RP2 is not fully understood. Here we report a novel in-frame 12-bp deletion (c.357_368del, p.Pro120_Gly123del) in zebrafish rp2 The mutant zebrafish shows reduced rod phototransduction proteins and progressive retinal degeneration...
April 14, 2017: Journal of Biological Chemistry
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