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https://www.readbyqxmd.com/read/28209709/pathogenic-mutations-in-retinitis-pigmentosa-2-predominantly-result-in-loss-of-rp2-protein-stability-in-human-and-zebrafish
#1
Fei Liu, Yayun Qin, Shanshan Yu, Dinesh C Soares, Lifang Yang, Jun Weng, Chang Li, Meng Gao, Zhaojing Lu, Xuebin Hu, Xiliang Liu, Tao Jiang, Jing Y Liu, Xinhua Shu, Zhaohui Tang, Mugen Liu
Mutations in retinitis pigmentosa 2 (RP2) account for 10-20% of X-linked retinitis pigmentosa (RP) cases. The encoded RP2 protein is implicated in ciliary trafficking of myristoylated and prenylated proteins in photoreceptor cells. To date, over 70 mutations in RP2 have been identified. How these mutations disrupt the function of RP2 is not fully understood. Here, we report a novel in-frame 12-bp deletion (c.357_368del, p.Pro120_Gly123del) in zebrafish rp2 The mutant zebrafish shows reduced rod phototransduction proteins and progressive retinal degeneration...
February 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28154170/tgf-%C3%AE-directly-activates-the-jak1-stat3-axis-to-induce-hepatic-fibrosis-in-coordination-with-smad-pathway
#2
Liu-Ya Tang, Mary Heller, ZhaoJing Meng, Li-Rong Yu, Yi Tang, Ming Zhou, Ying E Zhang
Transforming growth factor-β (TGF-β) signals through both SMAD and non-SMAD pathways to elicit a wide array of biological effects. Existing data have shown the association and coordination between STATs and SMADs in mediating TGF-β functions in hepatic cells, but it is not clear how STATs are activated under these circumstances. Here, we report that JAK1 is a constitutive TGFβRI binding protein and is absolutely required for phosphorylation of STATs in a SMADs-independent manner within minutes of TGF-β stimulation...
January 31, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28149995/trophic-transfer-of-hexabromocyclododecane-in-the-terrestrial-and-aquatic-food-webs-from-an-e-waste-dismantling-region-in-east-china
#3
Chaofei Zhu, Pu Wang, Yingming Li, Zhaojing Chen, Honghua Li, Patrick Ssebugere, Qinghua Zhang, Guibin Jiang
Trophic transfer of hexabromocyclododecane (HBCD) was investigated in both the terrestrial and aquatic food webs from an e-waste dismantling region in East China. The mean Σ3HBCD concentrations in the terrestrial species varied from 0.91 (0.16-1.85) ng g(-1) lipid weight (lw) in dragonflies (Pantala flavescens) to 40.3 (22.1-51.1) ng g(-1) lw in rats (Rattus norvegicus). The isomeric profile indicated that α-HBCD presented a decreasing trend along the trophic level (TL) (from 97.2% to 16.3% of Σ3HBCDs), while γ-HBCD showed a reverse trend (from 2...
February 2, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28143869/stabilization-of-notch1-by-the-hsp90-chaperon-is-crucial-for-t-cell-leukemogenesis
#4
Zhaojing Wang, Yufeng Hu, Daibiao Xiao, Jingchao Wang, Chuntao Liu, Yisheng Xu, Xiaomeng Shi, Peng Jiang, Liang Huang, Peng Li, Hudan Liu, Guoliang Qing
PURPOSE: Notch1 deregulation is assuming a focal role in T-cell acute lymphoblastic leukemia (T-ALL). Despite tremendous advances in our understanding of Notch1 transcriptional programs, the mechanisms by which Notch1 stability and turnover are regulated remain obscure. The goal of the present study is to identify intracellular Notch1 (ICN1, the activated form of Notch1) binding partner(s) regulating its stability and activity. EXPERIMENTAL DESIGN: We employed immunoaffinity purification to identify ICN1-associating partner and used co-immunoprecipitation to verify the endogenous protein interaction...
January 31, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27685320/quantitative-structure-activity-relationship-models-for-the-antioxidant-activity-of-polysaccharides
#5
Zhiming Li, Kaiying Nie, Zhaojing Wang, Dianhui Luo
In this study, quantitative structure activity relationship (QSAR) models for the antioxidant activity of polysaccharides were developed with 50% effective concentration (EC50) as the dependent variable. To establish optimum QSAR models, multiple linear regressions (MLR), support vector machines (SVM) and artificial neural networks (ANN) were used, and 11 molecular descriptors were selected. The optimum QSAR model for predicting EC50 of DPPH-scavenging activity consisted of four major descriptors. MLR model gave EC50 = 0...
2016: PloS One
https://www.readbyqxmd.com/read/27637096/catalytic-reduction-of-4-nitrophenol-using-gold-nanoparticles-biosynthesized-by-cell-free-extracts-of-aspergillus-sp-wl-au
#6
Wenli Shen, Yuanyuan Qu, Xiaofang Pei, Shuzhen Li, Shengnan You, Jingwei Wang, Zhaojing Zhang, Jiti Zhou
A facile one-pot eco-friendly process for synthesis of gold nanoparticles (AuNPs) with high catalytic activity was achieved using cell-free extracts of Aspergillus sp. WL-Au as reducing, capping and stabilizing agents. The surface plasmon resonance band of UV-vis spectrum at 532nm confirmed the presence of AuNPs. Transmission electron microscopy images showed that quite uniform spherical AuNPs were synthesized and the average size of nanoparticles increased from 4nm to 29nm with reaction time. X-ray diffraction analysis verified the formation of nano-crystalline gold particles...
July 21, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27572304/role-of-il-17-pathways-in-immune-privilege-a-rna-deep-sequencing-analysis-of-the-mice-testis-exposure-to-fluoride
#7
Meijun Huo, Haijun Han, Zilong Sun, Zhaojing Lu, Xinglei Yao, Shaolin Wang, Jundong Wang
We sequenced RNA transcripts from the testicles of healthy male mice, divided into a control group with distilled water and two experimental groups with 50 and 100 mg/l NaF in drinking water for 56 days. Bowtie/Tophat were used to align 50-bp paired-end reads into transcripts, Cufflinks to measure the relative abundance of each transcript and IPA to analyze RNA-Sequencing data. In the 100 mg/l NaF-treated group, four pathways related to IL-17, TGF-β and other cellular growth factor pathways were overexpressed...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27516247/structure-elucidation-of-a-non-branched-and-entangled-heteropolysaccharide-from-tremella-sanguinea-peng-and-its-antioxidant-activity
#8
Zhaojing Wang, Yawei Zeng, Dianhui Luo
A crude polysaccharide was extracted from the edible fungi Tremella sanguinea Peng, and a polysaccharide TSP-II (31.56%) was separated and purified from the crude polysaccharide. TSP-II was a homogeneous polysaccharide by the high-performance size-exclusion chromatography (HPSEC), had a molecular weight of 356kD and consisted mainly of mannose, xylose, galactose and glucose at a molar ratio 5.9:2.4:1:1.1. The structural assignment of TSP-II was carried out using fourier transform infrared spectroscopy (FTIR) analysis, periodate oxidation-smith degradation, partial hydrolysis with acid, methylation analysis and nuclear magnetic resonance (NMR) studies, and the repeating unit of TSP-II was thus determined...
November 5, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27454120/pdcd4-is-involved-in-the-formation-of-stress-granule-in-response-to-oxidized-low-density-lipoprotein-or-high-fat-diet
#9
Yang Bai, Zhaojing Dong, Qianwen Shang, Hui Zhao, Liyang Wang, Chun Guo, Fei Gao, Lining Zhang, Qun Wang
Stress granules (SGs) in response to various stresses have been reported in many diseases. We previously reported the implication of programmed cell death 4 (Pdcd4) in obesity-induced stress responses, but the possible link between Pdcd4 and SGs remains lacking. In this study we showed that oxidized low-density lipoprotein (ox-LDL) or high-fat diet (HFD) induced SG formation in mouse macrophages and liver tissues, and Pdcd4 deficiency in mice remarkably reduced its formation. In response to ox-LDL, either endogenous or ectopic Pdcd4 displayed granule-like expression and co-localized with SG markers including T-cell-restricted intracellular antigen-1, fragile X mental retardation-related protein 1, and eukaryotic initiation factor 4A...
2016: PloS One
https://www.readbyqxmd.com/read/27395407/three-novel-missense-mutations-in-the-filamin-b-gene-are-associated-with-isolated-congenital-talipes-equinovarus
#10
Haiou Yang, Zhaojing Zheng, Haiqing Cai, Huimin Li, Xingchen Ye, Xiaoqing Zhang, Zhigang Wang, Qihua Fu
Congenital talipes equinovarus (CTEV) is one of the most common musculoskeletal disorders. Genetic factors have been suggested to be an important contributor to its pathogenesis. Some genes, including PITX1, TBX4, and RBM10, have been associated with CTEV. We aimed to determine the disease-causing mutations in Chinese patients with isolated CTEV. Genomic DNA was extracted from peripheral blood samples of a three-generation pedigree and 53 sporadic patients with CTEV. Whole-exome sequencing and Sanger sequencing were used to identify and validate disease-causing mutations, respectively...
October 2016: Human Genetics
https://www.readbyqxmd.com/read/27360890/effects-of-repeated-exhaustive-exercise-on-mglur5-expression-in-the-rat-striate-nucleus-2065-board-217-june-2-2-00-pm-3-30-pm
#11
Meihua Su, Duoduo Yang, Zhaojing Chen, Charity Cavazos, Debra A Bemben, Michael G Bemben
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27359756/sarcopenia-osteopenia-and-functional-performance-in-postmenopausal-women-501-board-338-june-1-11-00-am-12-30-pm
#12
Zhaojing Chen, Pragya Sharma-Ghimire, Daeyeol Kim, Charity Cavazos, Michael G Bemben, Debra A Bemben
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27297394/microfilariae-of-brugia-malayi-inhibit-the-mtor-pathway-and-induce-autophagy-in-human-dendritic-cells
#13
Prakash Babu Narasimhan, Sasisekhar Bennuru, Zhaojing Meng, Rachel N Cotton, Kathleen R Elliott, Sundar Ganesan, Renee McDonald-Fleming, Timothy D Veenstra, Thomas B Nutman, Roshanak Tolouei Semnani
Immune modulation is a hallmark of patent filarial infection, including suppression of antigen-presenting cell function and downmodulation of filarial antigen-specific T cell responses. The mammalian target of rapamycin (mTOR) signaling pathway has been implicated in immune regulation, not only by suppressing T cell responses but also by regulating autophagy (through mTOR sensing amino acid availability). Global proteomic analysis (liquid chromatography-tandem mass spectrometry) of microfilaria (mf)-exposed monocyte-derived dendritic cells (DC) indicated that multiple components of the mTOR signaling pathway, including mTOR, eIF4A, and eIF4E, are downregulated by mf, suggesting that mf target this pathway for immune modulation in DC...
September 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27285984/microrna-218-inhibits-emt-migration-and-invasion-by-targeting-sfmbt1-and-dcun1d1-in-cervical-cancer
#14
Zhaojing Jiang, Qiancheng Song, Rong Zeng, Jing Li, Jingyu Li, Xiaochun Lin, Xing Chen, Jiren Zhang, Yanfang Zheng
Repeated infection with high-risk HPV is a major cause for the development and metastasis of human cervical cancer, even though the mechanism of the metastasis is still not completely understood. Here, we reported that miR-218 (microRNA-218) was downregulated in cervical cancer tissues, especially in metastatic cancer tissues. We found that miR-218 expression was associated with clinicopathological characteristics of patients with cervical cancer. MiR-218 overexpression inhibited Epithelial-Mesenchymal Transition (EMT), migration and invasiveness of cervical cancer cells in vitro...
July 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27241686/a-novel-gja1-mutation-identified-by-whole-exome-sequencing-in-a-chinese-family-with-autosomal-dominant-syndactyly
#15
Guolin You, Haiqing Cai, Limin Jiang, Zhaojing Zheng, Bo Wang, Qihua Fu, Jing Wang
No abstract text is available yet for this article.
August 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27160995/green-synthesis-of-gold-nanoparticles-by-a-newly-isolated-strain-trichosporon-montevideense-for-catalytic-hydrogenation-of-nitroaromatics
#16
Wenli Shen, Yuanyuan Qu, Xiaofang Pei, Xuwang Zhang, Qiao Ma, Zhaojing Zhang, Shuzhen Li, Jiti Zhou
OBJECTIVE: To investigate green synthesis of gold nanoparticles (AuNPs) by Trichosporon montevideense, and to study their reduction of nitroaromatics. RESULTS: AuNPs had a characteristic absorption maximum at 535 nm. Scanning electron microscopy images revealed that the biosynthesized nanoparticles were attached on the cell surface. X-ray diffraction analysis indicated that the particles formed as face-centered cubic (111)-oriented crystals. The average size of AuNPs decreased from 53 to 12 nm with increasing biomass concentration...
September 2016: Biotechnology Letters
https://www.readbyqxmd.com/read/27083337/structure-elucidation-of-a-major-fucopyranose-rich-heteropolysaccharide-stp-ii-from-sargassum-thunbergii
#17
Dianhui Luo, Xiumei Yuan, Yawei Zeng, Kaiying Nie, Zhiming Li, Zhaojing Wang
A crude polysaccharide was extracted from the edible algae S. thunbergii. DEAE-Sepharose CL-6B column chromatography was used to separate and purify a major polysaccharide STP-II (63.75%) from the crude polysaccharide. STP-II was found to be a homogeneous polysaccharide with a single peak by high-performance size-exclusion chromatography with a Sugar KS-804 column, have a molecular weight of 550 kD, and consist mainly of fucose, xylose, galactose, glucose and glucuronic acid. The structural assignment of STP-II was carried out using Fourier transform infrared spectroscopy analysis, periodate oxidation-smith degradation, partial hydrolysis with acid, methylation analysis and nuclear magnetic resonance studies, and the repeating unit of STP-II was thus determined...
June 5, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27052676/loss-of-function-mutation-in-pmvk-causes-autosomal-dominant-disseminated-superficial-porokeratosis
#18
Jiuxiang Wang, Ying Liu, Fei Liu, Changzheng Huang, Shanshan Han, Yuexia Lv, Chun-Jie Liu, Su Zhang, Yayun Qin, Lei Ling, Meng Gao, Shanshan Yu, Chang Li, Mi Huang, Shengjie Liao, Xuebin Hu, Zhaojing Lu, Xiliang Liu, Tao Jiang, Zhaohui Tang, Huiping Zhang, An-Yuan Guo, Mugen Liu
Disseminated superficial porokeratosis (DSP) is a rare keratinization disorder of the epidermis. It is characterized by keratotic lesions with an atrophic center encircled by a prominent peripheral ridge. We investigated the genetic basis of DSP in two five-generation Chinese families with members diagnosed with DSP. By whole-exome sequencing, we sequencing identified a nonsense variation c.412C > T (p.Arg138*) in the phosphomevalonate kinase gene (PMVK), which encodes a cytoplasmic enzyme catalyzing the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate in the mevalonate pathway...
April 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27049762/deubiquitinase-ubp5-is-required-for-the-growth-and-pathogenicity-of-cryptococcus-gattii
#19
Yunfang Meng, Chao Zhang, Jiu Yi, Zhaojing Zhou, Zhenzong Fa, Jingyu Zhao, Yali Yang, Wei Fang, Yan Wang, Wan-Qing Liao
Cryptococcus gattii is a resurgent fungal pathogen that primarily infects immunocompetent hosts. Thus, it poses an increasingly significant impact on global public health; however, the mechanisms underlying its pathogenesis remain largely unknown. We conducted a detailed characterization of the deubiquitinase Ubp5 in the biology and virulence of C. gattii using the hypervirulent strain R265, and defined its properties as either distinctive or shared with C. neoformans. Deletion of the C. gattii Ubp5 protein by site-directed disruption resulted in a severe growth defect under both normal and stressful conditions (such as high temperature, high salt, cell wall damaging agents, and antifungal agents), similar to the effects observed in C...
2016: PloS One
https://www.readbyqxmd.com/read/26942678/enhancer-of-rudimentary-cooperates-with-conserved-rna-processing-factors-to-promote-meiotic-mrna-decay-and-facultative-heterochromatin-assembly
#20
Tomoyasu Sugiyama, Gobi Thillainadesan, Venkata R Chalamcharla, Zhaojing Meng, Vanivilasini Balachandran, Jothy Dhakshnamoorthy, Ming Zhou, Shiv I S Grewal
Erh1, the fission yeast homolog of Enhancer of rudimentary, is implicated in meiotic mRNA elimination during vegetative growth, but its function is poorly understood. We show that Erh1 and the RNA-binding protein Mmi1 form a stoichiometric complex, called the Erh1-Mmi1 complex (EMC), to promote meiotic mRNA decay and facultative heterochromatin assembly. To perform these functions, EMC associates with two distinct complexes, Mtl1-Red1 core (MTREC) and CCR4-NOT. Whereas MTREC facilitates assembly of heterochromatin islands coating meiotic genes silenced by the nuclear exosome, CCR4-NOT promotes RNAi-dependent heterochromatin domain (HOOD) formation at EMC-target loci...
March 3, 2016: Molecular Cell
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