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https://www.readbyqxmd.com/read/29776543/a-near-infrared-ratiometric-turn-on-fluorescent-probe-for-in-vivo-imaging-of-hydrogen-peroxide-in-a-murine-model-of-acute-inflammation
#1
Jingli Hou, Meng Qian, Huanhuan Zhao, Yingchun Li, Yongfang Liao, Guifang Han, Zhelong Xu, Feng Wang, Yuguang Song, Yangping Liu
Much attention has been paid to develop optical probes for noninvasive, quantitative, in vivo monitoring of hydrogen peroxide (H2 O2 ) due to its important roles in the initiation and development of numerous diseases. Motivated to meet this need, we herein report the synthesis of a near-infrared (NIR) fluorescent probe (AB1) for H2 O2 by modulating intramolecular charge transfer (ICT) process of the dye 9H-1,3-Dichloro-7-hydroxy-9,9-dimethylacridine-2-one (DDAO). The probe AB1 exhibits both a large NIR fluorescence turn-on and a ratiometric response to H2 O2 with high sensitivity and specificity...
September 18, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29774076/the-human-somatostatin-receptor-type-2-as-an-imaging-and-suicide-reporter-gene-for-pluripotent-stem-cell-derived-therapy-of-myocardial-infarction
#2
Katrien Neyrinck, Natacha Breuls, Bryan Holvoet, Wouter Oosterlinck, Esther Wolfs, Hubert Vanbilloen, Olivier Gheysens, Robin Duelen, Willy Gsell, Ivo Lambrichts, Uwe Himmelreich, Catherine M Verfaillie, Maurilio Sampaolesi, Christophe M Deroose
Rationale: Pluripotent stem cells (PSCs) are being investigated as a cell source for regenerative medicine since they provide an infinitive pool of cells that are able to differentiate towards every cell type of the body. One possible therapeutic application involves the use of these cells to treat myocardial infarction (MI), a condition where billions of cardiomyocytes (CMs) are lost. Although several protocols have been developed to differentiate PSCs towards CMs, none of these provide a completely pure population, thereby still posing a risk for neoplastic teratoma formation...
2018: Theranostics
https://www.readbyqxmd.com/read/29773860/noninvasive-low-cycle-fatigue-characterization-at-high-depth-with-photoacoustic-eigen-spectrum-analysis
#3
Xiaoxiang Gao, Chao Tao, Rong Zhu, Xiaojun Liu
In this work, photoacoustic eigen-spectrum analysis was proposed for noninvasively characterizing the mechanical properties of materials. We theoretically predicted the relationship between the photoacoustic eigen-spectra of cylindrical optical absorbers and their mechanical properties. Experimental measurements of eigen-spectra extracted from photoacoustic coda waves agreed well with the theoretical predictions. We then applied the photoacoustic eigen-spectrum analysis for contactless monitoring of low-cycle fatigue damage...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768341/the-plethysmographic-variability-index-does-not-predict-fluid-responsiveness-estimated-by-esophageal-doppler-during-kidney-transplantation-a-controlled-study
#4
Morgan Le Guen, Arnaud Follin, Etienne Gayat, Marc Fischler
Research is ongoing to find a noninvasive method of monitoring, which can predict fluid responsiveness in patients undergoing kidney transplantation.To compare the responses to fluid challenges with the Pleth Variability Index, a noninvasive dynamic index derived from plethysmographic variability (Radical 7 pulse oximeter; Masimo Corporation, Irvine, CA), and the esophageal Doppler, the criterion standard.Observational study.University hospital; study from May 2011 and May 2012.Forty-eight patients with end-renal function were included and 44 analyzed...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29766686/multimodal-approach-in-assessment-of-the-response-of-breast-cancer-to-neoadjuvant-chemotherapy
#5
Mikhail Viktorovich Pavlov, Tatyana Igorevna Kalganova, Yekaterina Sergeevna Lyubimtseva, Vladimir Ivanovich Plekhanov, German Yurievich Golubyatnikov, Olga Yevgenyevna Ilyinskaya, Anna Gennadjevna Orlova, Pavel Vladimirovich Subochev, Dmitriy Vladimirovich Safonov, Natalia Mikhailovna Shakhova, Anna Vladimirovna Maslennikova
The ability for noninvasive visualization of functional changes of a tumor's oxygenation and circulatory system offers new advantages for prognosis and monitoring of the treatment efficacy. The results of breast cancer oxygen state study under chemotherapy action obtained by diffuse optical spectroscopy (DOS) in combination with Doppler ultrasonic imaging are presented. Complex use of optical and ultrasound methods gives complementary information about the size of the tumor node, peculiarities of its vascular bed, rate of its blood flow as well as oxygenation, and provide a picture of the tumor response to treatment...
May 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29764555/-role-of-noninvasive-mechanical-ventilation-in-patients-with-severe-avian-influenza-a-h7n9-complicated-with-acute-respiratory-distress-syndrome
#6
Haili Luo, Shaohong Wang, Feng Shen, Tongmei Yuan, Xianguo Pan, Jingtao Liu, Ling Yao, Juncheng Wu, Xuemei Long
Human infection with avian influenza A (H7N9) is an acute contagious respiratory disease. Acute respiratory distress syndrome (ARDS) is a common complication in patients with severe avian influenza A (H7N9), for whom mechanical ventilation (MV) is an important supportive method. A patient, suffered from severe avian influenza A (H7N9) and complicated with ARDS, was admitted to the Second Affiliated Hospital of Guizhou Medical University in January 2017. With very intensive care for oxygenation, respiration and consciousness, and monitoring, she was successfully cured by comprehensive managements, among which noninvasive mechanical ventilation (NIV) was the major respiratory support method...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29760785/monitoring-crohn-s-disease-activity-endoscopy-fecal-markers-and-computed-tomography-enterography
#7
Susana Lopes, Patrícia Andrade, Joana Afonso, Rui Cunha, Eduardo Rodrigues Pinto, Isabel Ramos, Guilherme Macedo, Fernando Magro
Background: The treatment goal of Crohn's disease (CD) has moved towards achieving mucosal healing, resolution of transmural inflammation, and normalization of biomarkers. The purpose of this study was to evaluate how well computed tomography enterography (CTE) and fecal calprotectin (FC) correlated with endoscopic activity in newly diagnosed patients with CD and after 1 year of therapy. Methods: Consecutive patients with newly diagnosed CD were evaluated by endoscopy, CTE, and FC at diagnosis and 12 months after beginning immunosuppression...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29760766/holistic-and-component-plant-phenotyping-using-temporal-image-sequence
#8
Sruti Das Choudhury, Srinidhi Bashyam, Yumou Qiu, Ashok Samal, Tala Awada
Background: Image-based plant phenotyping facilitates the extraction of traits noninvasively by analyzing large number of plants in a relatively short period of time. It has the potential to compute advanced phenotypes by considering the whole plant as a single object (holistic phenotypes) or as individual components, i.e., leaves and the stem (component phenotypes), to investigate the biophysical characteristics of the plants. The emergence timing, total number of leaves present at any point of time and the growth of individual leaves during vegetative stage life cycle of the maize plants are significant phenotypic expressions that best contribute to assess the plant vigor...
2018: Plant Methods
https://www.readbyqxmd.com/read/29756164/methods-for-the-determination-of-skeletal-muscle-blood-flow-development-strengths-and-limitations
#9
REVIEW
Lasse Gliemann, Stefan P Mortensen, Ylva Hellsten
Since the first measurements of limb blood flow at rest and during nerve stimulation were conducted in the late 1800s, a number of methods have been developed for the determination of limb and skeletal muscle blood flow in humans. The methods, which have been applied in the study of aspects such as blood flow regulation, oxygen uptake and metabolism, differ in terms of strengths and degree of limitations but most have advantages for specific settings. The purpose of this review is to describe the origin and the basic principles of the methods, important aspects and requirements of the procedures...
May 14, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29755977/wearable-technology-for-chronic-wound-monitoring-current-dressings-advancements-and-future-prospects
#10
REVIEW
Matthew S Brown, Brandon Ashley, Ahyeon Koh
Chronic non-healing wounds challenge tissue regeneration and impair infection regulation for patients afflicted with this condition. Next generation wound care technology capable of in situ physiological surveillance which can diagnose wound parameters, treat various chronic wound symptoms, and reduce infection at the wound noninvasively with the use of a closed loop therapeutic system would provide patients with an improved standard of care and an accelerated wound repair mechanism. The indicating biomarkers specific to chronic wounds include blood pressure, temperature, oxygen, pH, lactate, glucose, interleukin-6 (IL-6), and infection status...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29754656/the-prognostic-value-of-heart-rate-recovery-in-patients-with-coronary-artery-disease-a-systematic-review-and-meta-analysis
#11
REVIEW
Sangeeta Lachman, Michel S Terbraak, Jacqueline Limpens, Harald Jorstad, Cees Lucas, Wilma Scholte Op Reimer, S Matthijs Boekholdt, Gerben Ter Riet, Ron J G Peters
BACKGROUND: Routine outpatient care of patients with coronary artery disease (CAD) lacks a simple measure of physical fitness and risk of mortality. Heart rate recovery (HRR) is noninvasive and easily obtainable in outpatient settings. Prior studies have suggested that delayed postexercise HRR in the first minutes is associated with mortality in several types of populations. However, a comprehensive overview of the prognostic value of delayed HRR for time to mortality specifically in CAD patients is not available...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29750725/face-transplant-status-of-current-supporting-technology-to-plan-and-perform-the-operation-and-monitor-the-graft-in-the-postoperative-period
#12
Edward J Caterson, Justin C McCarty
Face transplant has rapidly advanced since the first operation in 2005, and to date, 40 partial or full-face transplants have been performed. The safety and efficacy of this operation are aided at all phases by supporting technologies. These include advanced imaging techniques to plan the operation, devices to monitor the flap in the immediate perioperative period, and noninvasive imaging and serum markers to monitor for acute and chronic rejection. Some of the technologies, such as those used in the immediate perioperative period, have extensive evidence supporting their use, whereas those to detect acute or chronic rejection remain investigational...
May 10, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29748585/humanizing-miniature-hearts-through-4-flow-cannulation-perfusion-decellularization-and-recellularization
#13
Duong T Nguyen, Matthew O'Hara, Cecilia Graneli, Ryan Hicks, Tasso Miliotis, Ann-Christin Nyström, Sara Hansson, Pia Davidsson, Li-Ming Gan, Maria Chiara Magnone, Magnus Althage, Sepideh Heydarkhan-Hagvall
Despite improvements in pre-clinical drug testing models, predictability of clinical outcomes continues to be inadequate and costly due to poor evidence of drug metabolism. Humanized miniature organs integrating decellularized rodent organs with tissue specific cells are translational models that can provide further physiological understanding and evidence. Here, we evaluated 4-Flow cannulated rat hearts as the fundamental humanized organ model for cardiovascular drug validation. Results show clearance of cellular components in all chambers in 4-Flow hearts with efficient perfusion into both coronary arteries and cardiac veins...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29746434/serum-and-saliva-concentrations-of-venlafaxine-o-desmethylvenlafaxine-quetiapine-and-citalopram-in-psychiatric-patients
#14
Katharina Ebert, Elena Maurice, Richard Lukačin, Christian Fleischhaker, Eberhard Schulz, Dieter Ebert, Hans-Willi Clement
BACKGROUND: Therapeutic drug monitoring has become increasingly important in psychiatric therapy. However, it is not yet implemented as a daily routine in clinical settings. To evaluate new, noninvasive procedures, we compared blood and saliva venlafaxine, quetiapine, and citalopram concentrations in samples collected from psychiatric patients. METHODS: We collected blood and saliva samples from 75 psychiatric patients (39 venlafaxine, 19 quetiapine, and 17 citalopram)...
June 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29746090/a-gold-silver-hybrid-nanoparticle-for-treatment-and-photoacoustic-imaging-of-bacterial-infection
#15
Taeho Kim, Qiangzhe Zhang, Jin Li, Liangfang Zhang, Jesse V Jokerst
Ag+ ions are a well-known antibacterial agent, and Ag nanoparticles act as a reservoir of these Ag+ ions for targeted therapy of bacterial infections. However, there are no tools to effectively trigger and monitor the release of Ag+ ions from Ag nanoparticles. Photoacoustic (PA) imaging is an emerging noninvasive imaging tool, and gold nanorods (AuNRs) are an excellent contrast agent for PA imaging. In this work, we developed Au/Ag hybrid nanoparticles by coating AuNRs with silver (Ag), which decreased their photoacoustic signal...
May 10, 2018: ACS Nano
https://www.readbyqxmd.com/read/29745622/noninvasive-assessment-of-cardiac-index-using-impedance-cardiography-during-liver-transplantation-surgery-a-comparison-with-pulmonary-artery-thermodilution
#16
Vlad Suparschi, Eric Le Bihan, Amélie Toussaint, Diana Saptefrat, Heykel Ben Abdallah, Faouzi Gloulou, Farida Aouati, Tobias Gauss, Catherine Paugam-Burtz
BACKGROUND: Liver Transplantation (LT) is a high-risk surgery associated with significant hemodynamic changes requiring advanced hemodynamic monitoring. Pulmonary Artery Catheter (PAC) is still considered as a gold-standard for cardiac index (CI) measurement during LT despite association with an increased risk of complications. Noninvasive impedance cardiography (ICG) could be an interesting alternative tool for CI monitoring. The aim of this study was to compare the precision and trending ability of ICG versus PAC methods during LT...
May 9, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29745535/-novel-type-of-unperturbed-sleep-monitoring-scheme-under-pillow-based-on-hidden-markov-model
#17
Xiang Li, Yong Liu, Pengbin Chen, Jiewei Wu, Han Zhang
Sleep status is an important indicator to evaluate the health status of human beings. In this paper, we proposed a novel type of unperturbed sleep monitoring system under pillow to identify the pattern change of heart rate variability (HRV) through obtained RR interval signal, and to calculate the corresponding sleep stages combined with hidden Markov model (HMM) under the no-perception condition. In order to solve the existing problems of sleep staging based on HMM, ensemble empirical mode decomposition (EEMD) was proposed to eliminate the error caused by the individual differences in HRV and then to calculate the corresponding sleep stages...
April 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29745269/biophysical-and-photobiological-basics-of-water-filtered-infrared-a-hyperthermia-of-superficial-tumors
#18
Peter Vaupel, Helmut Piazena, Werner Müller, Markus Notter
Thermography-controlled, water-filtered infrared-A (wIRA) is a novel, effective and approved heating technique listed in the ESHO quality assurance guidelines for superficial hyperthermia clinical trials (2017). In order to assess the special features and the potential of wIRA-hyperthermia (wIRA-HT), detailed and updated information about its physical and photobiological background is presented. wIRA allows for (a) application of high irradiances without skin pain and acute grade 2-4 skin toxicities, (b) prolonged, therapeutically relevant exposure times using high irradiances (150-200 mW/cm2 ) and (c) faster and deeper heat extension within tissues...
May 10, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29744017/spontaneous-recanalization-after-carotid-artery-dissection-the-case-for-an-ultrasound-only-monitoring-strategy
#19
Sarah Lumsden, Gabor Rosta, Jean Bismuth, Alan B Lumsden, Zsolt Garami
Dissection of the internal carotid artery (ICA) accounts for 5% to 25% of ischemic strokes in young adults. We report a case of spontaneous recanalization of a traumatic ICA dissection in which carotid duplex (CDU) and transcranial color-coded duplex ultrasound (TCCD) were used. A 47-year-old male presented with intermittent episodes of headache, blurry vision, anisocoria, and loss of taste sensation following a whiplash injury while body surfing. Magnetic resonance angiogram (MRA) of the neck revealed absent flow in the cavernous ICA and a clot at the skull base...
October 2017: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/29743993/complex-structural-interventions-the-role-of-computed-tomography-fluoroscopy-and-fusion-imaging
#20
REVIEW
Mohammad A Hussain, Faisal Nabi
Noninvasive cardiac imaging has played a critical part in the evaluation, monitoring, and follow-up of structural heart disease. This review will highlight the role of cardiac computed tomography, fluoroscopy, and fusion imaging in guiding transcatheter aortic valve replacement and other percutaneous strategies used to diagnose and treat complex structural heart complications.
July 2017: Methodist DeBakey Cardiovascular Journal
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